32 results on '"Jürgen Reul"'
Search Results
2. Language Mapping in Less Than 15 Minutes: Real-Time Functional MRI during Routine Clinical Investigation.
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Guillén Fernández, Armin de Greiff, Joachim von Oertzen, Markus Reuber, Sigrid Lun, Peter Klaver, Jürgen Ruhlmann, Jürgen Reul, and Christian Erich Elger
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- 2001
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3. Cerebral lesions can impair fMRI-based language lateralization
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Horst Urbach, Jörg Wellmer, Jürgen Reul, Guillén Fernández, Christian E. Elger, and Bernd Weber
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Electroencephalography ,Audiology ,Brain mapping ,Functional Laterality ,Lateralization of brain function ,Lesion ,Epilepsy ,Image Processing, Computer-Assisted ,medicine ,Humans ,Child ,Aged ,Language ,Brain Diseases ,Brain Mapping ,medicine.diagnostic_test ,Brain Neoplasms ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Frontal Lobe ,Semantics ,Oxygen ,Functional imaging ,Neurology ,Amobarbital ,Wada test ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Functional magnetic resonance imaging ,Functional Neurogenomics [DCN 2] ,Neuroscience ,Psychomotor Performance - Abstract
Contains fulltext : 80155.pdf (Publisher’s version ) (Closed access) PURPOSE: Several small patient studies and case reports raise concerns that the reliability of functional magnetic resonance imaging (fMRI) may be impaired in the vicinity of cerebral lesions. This could affect the clinical validity of fMRI for presurgical language lateralization. The current study sets out to identify if a systematic effect of lesion type and localization on fMRI exists. METHODS: We classify lesions typically occurring in epilepsy patients according to (1) their potential to disturb blood oxygenation level dependent (BOLD)-effect generation or detection or to disturb spatial brain normalization, and (2) the proximity of lesions to protocol-specific volumes of interest (VOIs). The effect of lesions is evaluated through the examination of 238 epilepsy patients and a subgroup of 37 patients with suspected unilateral left-language dominance according to the Wada test. RESULTS: Patients with fMRI-critical lesions such as cavernomas, gliomas, and mass defects close to VOIs, or with severe atrophy, show lower lateralization indices (LIs) and more often discordant language lateralization with the Wada test than do patients without such lesions. DISCUSSION: This study points seriously toward fMRI-language lateralization being sensitive to cerebral lesions. Some lesion types and locations are more critical than others. Our results question the noncritical application of fMRI in patients with cerebral lesions.
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- 2009
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4. 'Soundmorphing': A new approach to studying speech perception in humans
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Kenneth Hugdahl, Jürgen Reul, Lars M. Rimol, and Karsten Specht
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Adult ,Male ,medicine.medical_specialty ,Speech perception ,media_common.quotation_subject ,Audiology ,Auditory cortex ,Temporal lobe ,Tone (musical instrument) ,Gyrus ,Phonetics ,Perception ,medicine ,Humans ,Speech ,media_common ,Auditory Cortex ,Brain Mapping ,General Neuroscience ,Dose-Response Relationship, Radiation ,Acoustics ,SMA ,Speech processing ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Acoustic Stimulation ,Speech Perception ,Female ,Psychology ,Neuroscience - Abstract
A problem in current studies of brain activation in speech perception is that most studies use stimuli that are sampled from different categories. This study presents a new approach in creating acoustic stimuli by filtering real words in different ways, thus this enables one to ‘morph’ the sounds gradually from something like tones to real words while preserving temporal characteristics (“soundmorphing”). This will make it possible to explore steps between tone and speech processing on a gradual scale. This study aimed to investigate more closely the network, involved in the perception of speech and the decoding of auditory (speech-)stimuli. Sets of auditory stimuli were created by dividing real words into several frequency-bands and creating a randomised rearrangement of these components. Four different sets of stimuli were used, containing 1, 2, 3 or 4 frequency bands (total range: 0–2500 Hz). Only the latter one contained intelligible words. During the fMRI session, these four trial types were presented pseudo-randomised. In all conditions, significant activations of auditory cortex were observed. The number of activated voxels and their significance increased over the four trial types. In addition, Broca's area, SMA, left thalamus, and right cerebellum were activated in the most complex and most speech-like condition. Comparing these complexes with the tone-like trials, only the left auditory cortex, left SMA, and cingulate gyrus became significant. These activations reflect the bilateral processing of the auditory stimuli, but only the left temporal areas demonstrated an increasing BOLD response with an increasing number of presented frequency components.
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- 2005
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5. Differences of cerebral activation between superior and inferior learners during motor sequence encoding and retrieval
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Jürgen Reul, Reinhard Heun, Frank Jessen, N. Freymann, Katrin Barkow, Christian Paul Stracke, and Dirk Oliver Granath
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Adult ,Male ,education ,Neuroscience (miscellaneous) ,Posterior parietal cortex ,Reaction Time ,medicine ,Humans ,Learning ,Middle frontal gyrus ,Radiology, Nuclear Medicine and imaging ,Prefrontal cortex ,medicine.diagnostic_test ,Supplementary motor area ,Parietal lobe ,Brain ,Achievement ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,medicine.anatomical_structure ,Finger tapping ,Female ,Motor learning ,Functional magnetic resonance imaging ,Psychology ,Neuroscience ,Psychomotor Performance - Abstract
Cerebral activation during memory encoding and retrieval might depend on subjects' learning capacity, either by corresponding to better performance in superior learners or by reflecting increased effort in inferior learners. To investigate these alternative hypotheses, the study compared cerebral activation during encoding and retrieval of a motor sequence in groups of subjects with superior and inferior learning performances. Ten healthy subjects underwent functional magnetic resonance imaging (fMRI) while performing a motor sequence encoding paradigm (i.e. finger tapping sequence) and a retrieval paradigm (i.e. reproduction of the learned sequence). Subjects were divided into superior and inferior learners according to the correctness of sequence reproduction during retrieval. During encoding, there was strong bilateral activation in the middle frontal gyrus, the supplementary motor area (SMA), the lateral parietal lobe and the cerebellum. During retrieval, again strong activation was found in identical areas of the prefrontal cortex, the parietal lobe and the cerebellum. During encoding, inferior learners showed more left-sided activations in the left middle frontal and inferior parietal gyri. Superior learners showed increased activation in the corresponding right-sided brain areas during encoding as well as during retrieval. Differences of cerebral activations in the prefrontal and parietal cortex during encoding and retrieval were found to be related to retrieval performance, i.e. success and effort. Further intervention studies are needed to assess whether these interindividual differences are the cause or the consequence of differences in memory performance.
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- 2004
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6. Temporal and cerebellar brain regions that support both declarative memory formation and retrieval
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Peter Klaver, Guillén Fernández, Susanne Weis, Jürgen Reul, and Christian E. Elger
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Adult ,Male ,Cognitive Neuroscience ,Interference theory ,Temporal lobe ,Cellular and Molecular Neuroscience ,Visual memory ,Cognitive neurosciences [UMCN 3.2] ,Memory ,Difference due to memory ,Cerebellum ,Image Processing, Computer-Assisted ,Reaction Time ,Semantic memory ,Humans ,Late positive component ,Recognition memory ,Brain Mapping ,Working memory ,Middle Aged ,Magnetic Resonance Imaging ,Temporal Lobe ,Mental Recall ,Visual Perception ,Female ,Psychology ,Neuroscience - Abstract
Contains fulltext : 57192.pdf (Publisher’s version ) (Closed access) Using event-related fMRI, we scanned young healthy subjects while they memorized real-world photographs and subsequently tried to recognize them within a series of new photographs. We confirmed that activity in the medial temporal lobe (MTL) and inferior prefrontal cortex correlates with declarative memory formation as defined by the subsequent memory effect, stronger responses to subsequently remembered than forgotten items. Additionally, we confirmed that activity in specific regions within the parietal lobe, anterior prefrontal cortex, anterior cingulate and cerebellum correlate with recognition memory as measured by the conventional old/new effect, stronger responses for recognized old items (hits) than correctly identified new items (correct rejections). To obtain a purer measure of recognition success, we introduced two recognition effects by comparing brain responses to hits and old items misclassified as new (misses). The positive recognition effect (hits > misses) revealed prefrontal, parietal and cerebellar contributions to recognition, and in line with electrophysiological findings, the negative recognition effect (hits < misses) revealed an anterior medial temporal contribution. Finally, by inclusive masking, we identified temporal and cerebellar brain areas that support both declarative memory formation and retrieval. For matching operations during recognition, these areas may re-use representations formed and stored locally during encoding.
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- 2004
7. Plug & Play fMRI
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Kenneth Hugdahl, Jürgen Reul, Tormod Thomsen, Lars Ersland, Karsten Specht, and Erling Andersen
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Plug play ,Radiological and Ultrasound Technology ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Neurology (clinical) ,business ,Neuroscience - Published
- 2003
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8. MRT und epileptogene Foci
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Christian E. Elger, Jürgen Reul, Horst Urbach, and J. von Oertzen
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Hippocampal sclerosis ,Epilepsy ,Pathology ,medicine.medical_specialty ,business.industry ,Physiology (medical) ,Medicine ,Neurology (clinical) ,business ,medicine.disease ,Neuroscience - Published
- 2000
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9. Endoscopic Treatment Approaches to Herniated Lumbar Disks
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Jürgen Reul
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medicine.medical_specialty ,Percutaneous ,Nerve root ,business.industry ,medicine.medical_treatment ,Facet joint ,Surgery ,Lumbar ,medicine.anatomical_structure ,Electrotherapy ,medicine ,Spinal canal ,Diskectomy ,business ,Endoscopic treatment - Abstract
Several minimally invasive image-guided methods have been developed to treat diseases in lumbar disks (e.g., automated percutaneous lumbar diskectomy, laser diskectomy, intradiskal electrotherapy). Nearly all of these methods provide a good approach to the disk space and nucleus. However, removal of sequestered disk fragments that have into the spinal canal or neuroforamen is extremely difficult.
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- 2013
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10. Oxytocin facilitates protective responses to aversive social stimuli in males
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Wolfgang Maier, Benjamin Becker, Nadine Striepens, Knut Schwalba, Dirk Scheele, René Hurlemann, Jürgen Reul, Lea Schäfer, and Keith M. Kendrick
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Male ,Neuropeptide ,Mnemonic ,Oxytocin ,Amygdala ,Arousal ,Placebos ,physiology [Brain] ,Double-Blind Method ,medicine ,Avoidance Learning ,Humans ,Valence (psychology) ,Multidisciplinary ,Brain ,Social cue ,Biological Sciences ,Magnetic Resonance Imaging ,physiology [Oxytocin] ,medicine.anatomical_structure ,Female ,ddc:500 ,Psychology ,Insula ,Neuroscience ,psychological phenomena and processes ,hormones, hormone substitutes, and hormone antagonists ,Cognitive psychology ,medicine.drug - Abstract
The neuropeptide oxytocin (OXT) can enhance the impact of positive social cues but may reduce that of negative ones by inhibiting amygdala activation, although it is unclear whether the latter causes blunted emotional and mnemonic responses. In two independent double-blind placebo-controlled experiments, each involving over 70 healthy male subjects, we investigated whether OXT affects modulation of startle reactivity by aversive social stimuli as well as subsequent memory for them. Intranasal OXT potentiated acoustic startle responses to negative stimuli, without affecting behavioral valence or arousal judgments, and biased subsequent memory toward negative rather than neutral items. A functional MRI analysis of this mnemonic effect revealed that, whereas OXT inhibited amygdala responses to negative stimuli, it facilitated left insula responses for subsequently remembered items and increased functional coupling between the left amygdala, left anterior insula, and left inferior frontal gyrus. Our results therefore show that OXT can potentiate the protective and mnemonic impact of aversive social information despite reducing amygdala activity, and suggest that the insula may play a role in emotional modulation of memory.
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- 2012
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11. Strongly lateralized activation in language fMRI of atypical dominant patients-implications for presurgical work-up
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Christian E. Elger, Jürgen Reul, Bernd Weber, Peter Klaver, Susanne Weis, Guillén Fernández, Horst Urbach, and Jörg Wellmer
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Adult ,Male ,Adolescent ,Neuroinformatics [DCN 3] ,behavioral disciplines and activities ,Central nervous system disease ,Epilepsy ,Cognitive neurosciences [UMCN 3.2] ,medicine ,Image Processing, Computer-Assisted ,Humans ,Epilepsy surgery ,Dominance, Cerebral ,Dominance (genetics) ,Language ,Brain Mapping ,Language Tests ,medicine.diagnostic_test ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Work-up ,Frontal Lobe ,Functional imaging ,Oxygen ,Neurology ,Wada test ,Female ,Neurology (clinical) ,Psychology ,Functional magnetic resonance imaging ,Functional Neurogenomics [DCN 2] ,Neuroscience - Abstract
Contains fulltext : 70951.pdf (Publisher’s version ) (Closed access) PURPOSE: Functional magnetic resonance imaging (fMRI) is being used increasingly for language dominance assessment in the presurgical work-up of patients with pharmacoresistant epilepsy. However, the interpretation of bilateral fMRI-activation patterns is difficult. Various studies propose fMRI-lateralization index (LI) thresholds between +/-0.1 and +/-0.5 for discrimination of atypical from typical dominant patients. This study examines if these thresholds allow identifying atypical dominant patients with sufficient safety for presurgical settings. METHODS: 65 patients had a tight comparison, fully controlled semantic decision fMRI-task and a Wada-test for language lateralization. According to Wada-test, 22 were atypical language dominant. In the remaining, Wada-test results were compatible with unilateral left dominance. We determined fMRI-LI for two frontal and one temporo-parietal functionally defined, protocol-specific volume of interest (VOI), and for the least lateralized of these VOIs ("low-VOI") in each patient. RESULTS: We find large intra-individual LI differences between functionally defined VOIs irrespective of underlying type of language dominance (mean LI difference 0.33+/-0.35, range 0-1.6; 15% of patients have inter-VOI-LI differences >1.0). Across atypical dominant patients fMRI-LI in the Broca's and temporo-parietal VOI range from -1 to +1, in the "remaining frontal" VOI from -0.93 to 1. The highest low-VOI-LI detected in atypical dominant patients is 0.84. CONCLUSIONS: Large intra-individual inter-VOI-LI differences and strongly lateralized fMRI-activation in patients with Wada-test proven atypical dominance question the value of the proposed fMRI-thresholds for presurgical language lateralization. Future studies have to develop strategies allowing the reliable identification of atypical dominance with fMRI. The low-VOI approach may be useful.
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- 2007
12. Under which Condition can fMRI Replace the Intracarotid Amobarbital Procedure (IAP) for Presurgical Language Lateralization?
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Jürgen Reul, Susanne Weis, M. Kurthen, Guillén Fernández, D. B. Linke, Horst Urbach, Peter Klaver, Christian E. Elger, Jürgen Ruhlmann, and Jörg Wellmer
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Cognitive science ,medicine.medical_specialty ,Physiology (medical) ,Amobarbital ,medicine ,Neurology (clinical) ,Audiology ,Psychology ,Language lateralization ,medicine.drug - Published
- 2004
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13. Neural correlates of successful declarative memory formation and retrieval: the anatomical overlap
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Jürgen Reul, Guillén Fernández, Susanne Weis, Christian E. Elger, and Peter Klaver
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Cognitive science ,Cerebral Cortex ,Neurons ,Neural correlates of consciousness ,Brain Mapping ,business.industry ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Recognition, Psychology ,Magnetic Resonance Imaging ,Random Allocation ,Neuropsychology and Physiological Psychology ,Text mining ,Memory ,Reference Values ,Mental Recall ,Semantic memory ,Evoked Potentials, Visual ,Humans ,Learning ,business ,Psychology ,Declarative memory ,Photic Stimulation ,Cognitive psychology - Published
- 2004
14. Cranial magnetic resonance imaging in genetically proven myotonic dystrophy type 1 and 2
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Thomas Klockgether, Jürgen Reul, Niki Amanatidis, Wolfram Kress, Christoph Grothe, Rolf Schröder, and Cornelia Kornblum
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Adult ,Male ,musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Pathology ,Neurology ,Neuropsychological Tests ,Myotonic dystrophy ,Proximal myotonic myopathy ,Atrophy ,medicine ,Humans ,Myotonic Dystrophy ,Aged ,Neuroradiology ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Myotonia ,Magnetic Resonance Imaging ,Hyperintensity ,Female ,Neurology (clinical) ,Cognition Disorders ,business - Abstract
Cranial magnetic resonance imaging (MRI) in 19 German patients with genetically proven myotonic dystrophy Type 1 (DM1, n = 10) or Type 2 (DM2, n = 9) showed pathological findings consisting of white matter lesions (WML) and/or brain atrophy in 9/10 DM1 and 8/9 DM2 patients. Anterior temporal WML (ATWML) were exclusively seen in DM1 patients. Our findings indicate a high frequency of central nervous system (CNS) involvement in both disorders. However, temporopolar pathology, previously associated with intellectual dysfunction, seems to be restricted to DM1.
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- 2004
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15. Evidence for a dysfunctional retrosplenial cortex in patients with schizophrenia: a functional magnetic resonance imaging study with a semantic-perceptual contrast
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Anke Brockhaus-Dumke, Stephan Ruhrmann, Oliver Guddat, Indira Tendolkar, Susanne Weis, Karsten Specht, Guillén Fernández, Joachim Klosterkötter, and Jürgen Reul
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Male ,Neuropsychological Tests ,behavioral disciplines and activities ,Functional Laterality ,Judgment ,Retrosplenial cortex ,Cognitive neurosciences [UMCN 3.2] ,Cortex (anatomy) ,medicine ,Determinants in Health and Disease [EBP 1] ,Limbic System ,Humans ,Prefrontal cortex ,Brain Mapping ,medicine.diagnostic_test ,Working memory ,General Neuroscience ,Magnetic Resonance Imaging ,Frontal Lobe ,Semantics ,Dorsolateral prefrontal cortex ,Oxygen ,medicine.anatomical_structure ,Posterior cingulate ,Case-Control Studies ,Schizophrenia ,Orbitofrontal cortex ,Psychology ,Functional magnetic resonance imaging ,Neuroscience - Abstract
Contains fulltext : 58541.pdf (Publisher’s version ) (Closed access) We investigated whether the retrosplenial and the posterior cingulate cortex (RS-PCC) is functionally impaired in schizophrenia patients. Therefore, we measured functional magnetic resonance imaging (fMRI) signal changes associated with a synonym-judgment task known to activate, among other areas, the RS-PCC. Compared to 12 matched control subjects, 12 schizophrenia patients exhibited reliably weaker activations in the RS-PCC, the dorsolateral prefrontal cortex and the left orbitofrontal cortex (P < 0.05, corrected). Differences in frontal activations are in line with previous studies showing a structurally and functionally affected prefrontal cortex in schizophrenia. The impaired RS-PCC functionality in a semantic task may relate to verbal memory deficits frequently observed in schizophrenia patients, because this region is pivotal for gating information into the medial temporal lobe memory system.
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- 2004
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16. Using visual advance information: an event-related functional MRI study
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Armin de Greiff, Christian E. Elger, Jürgen Ruhlmann, Jürgen Reul, Jürgen Fell, Susanne Weis, Guillén Fernández, and Peter Klaver
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Adult ,Male ,Cognitive Neuroscience ,media_common.quotation_subject ,Motion Perception ,Color ,Experimental and Cognitive Psychology ,Sensory system ,Stimulus (physiology) ,Behavioral Neuroscience ,Cognition ,Cognitive neurosciences [UMCN 3.2] ,Perception ,medicine ,Reaction Time ,Humans ,media_common ,Cerebral Cortex ,Supplementary motor area ,Stimulus onset asynchrony ,Magnetic Resonance Imaging ,Functional imaging ,medicine.anatomical_structure ,Evoked Potentials, Visual ,Female ,Psychology ,Neuroscience ,Perceptual information - Abstract
Contains fulltext : 59134.pdf (Publisher’s version ) (Closed access) Our event-related functional MRI (efMRI) study investigates whether visual advance information (AI) affects rather perceptual or central response-related processing areas. Twelve subjects were required to make a go/no-go decision to a conjunction of a specific color and motion direction. The stimuli were preceded by a cue, providing 100% valid advance information about motion direction. Partial and full advance information (PAI and FAI) predicted possible targets, respectively, certain nontargets, neutral cues (NAI) gave no prediction. The time between cue and stimulus (stimulus onset asynchrony, SOA) was varied. A response benefit was found after PAI as compared with NAI. The benefit was small with a short SOA (150 ms), increased with intermediate SOA (450 ms) and sustained with long SOA (750 ms). Perceptual and central processing areas were more active with increasing SOA, but only central response-related processing areas were selectively modulated by cue information. In particular, supplementary motor area and bilateral inferior parietal lobe were more active with PAI than with NAI. If comparing NAI with FAI, more errors were made and activity was larger in central processing areas. Our results suggest that, depending on the processing time, cues providing perceptual information modulate central response-related processes.
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- 2004
17. Präoperative Sprachlateralisation mittels fMRT: Durchführbarkeit und Validität eines semantisch-perzeptuellen Designs
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D. B. Linke, Christian E. Elger, Jürgen Reul, Susanne Weis, M. Kurthen, Guillén Fernández, and Jörg Wellmer
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Physiology (medical) ,Neurology (clinical) - Published
- 2003
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18. Menstrual cycle-dependent neural plasticity in the adult human brain is hormone, task, and region specific
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Juergen Fell, Christian E. Elger, Stefan Beyenburg, Jürgen Reul, Guillén Fernández, Susanne Weis, Indira Tendolkar, Armin de Greiff, Markus Reuber, Birgit Stoffel-Wagner, Peter Klaver, and Jürgen Ruhlmann
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Adult ,Brain activity and meditation ,medicine.medical_treatment ,Synaptogenesis ,Poison control ,Luteal Phase ,Lateralization of brain function ,Cognitive neurosciences [UMCN 3.2] ,Reference Values ,Neuroplasticity ,medicine ,Determinants in Health and Disease [EBP 1] ,Reaction Time ,Humans ,Testosterone ,ARTICLE ,Dominance, Cerebral ,Menstrual Cycle ,Progesterone ,Behavior ,Brain Mapping ,Neuronal Plasticity ,medicine.diagnostic_test ,Estradiol ,Verbal Behavior ,General Neuroscience ,Brain ,Human brain ,Magnetic Resonance Imaging ,Hormones ,Menstruation ,Steroid hormone ,medicine.anatomical_structure ,Linear Models ,Female ,Follicle Stimulating Hormone ,Functional magnetic resonance imaging ,Psychology ,Neuroscience ,Photic Stimulation - Abstract
Contains fulltext : 135771.pdf (Publisher’s version ) (Open Access) In rodents, cyclically fluctuating levels of gonadal steroid hormones modulate neural plasticity by altering synaptic transmission and synaptogenesis. Alterations of mood and cognition observed during the menstrual cycle suggest that steroid-related plasticity also occurs in humans. Cycle phase-dependent differences in cognitive performance have almost exclusively been found in tasks probing lateralized neuronal domains, i.e., cognitive domains such as language, which are predominantly executed by one hemisphere. To search for neural correlates of hormonally mediated neural plasticity in humans, we thus conducted a functional magnetic resonance imaging study measuring brain activity related to a semantic decision task in the language domain. This was contrasted with a letter-matching task in the perceptual domain, in which we expected no steroid hormone-mediated effect. We investigated 12 young healthy women in a counterbalanced repeated-measure design during low-steroid menstruation and high-steroid midluteal phase. Steroid serum levels correlated with the volume and lateralization of particular brain activations related to the semantic task but not with brain activity related to the perceptual task. More specifically, bilateral superior temporal recruitment correlated positively with progesterone and medial superior frontal recruitment with both progesterone and estradiol serum levels, whereas activations in inferior and middle frontal cortex were unaffected by steroid levels. In contrast to these specific interactions, testosterone levels correlated nonselectively with overall activation levels by neural and/or vascular factor(s). In conclusion, our data demonstrate steroid hormone responsivity in the adult human brain by revealing neural plasticity in the language domain, which appears hormone, task, and region specific.
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- 2003
19. Language mapping in less than 15 minutes: real-time functional MRI during routine clinical investigation
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Markus Reuber, Peter Klaver, Armin de Greiff, Joachim von Oertzen, Jürgen Reul, Guillén Fernández, Sigrid Lun, Christian E. Elger, and Jürgen Ruhlmann
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Brain activity and meditation ,Cognitive Neuroscience ,Drug Resistance ,Audiology ,Lateralization of brain function ,Premotor cortex ,Software ,Computer Systems ,Clinical investigation ,medicine ,Humans ,Epilepsy surgery ,Dominance, Cerebral ,Language lateralization ,Language ,Brain Mapping ,Electronic Data Processing ,Epilepsy ,Language Tests ,business.industry ,Middle Aged ,Magnetic Resonance Imaging ,Dorsolateral prefrontal cortex ,medicine.anatomical_structure ,Neurology ,Anticonvulsants ,Female ,Psychology ,business ,Neuroscience - Abstract
Neurosurgical interventions often require the presurgical determination of language dominance or mapping of language areas. Results obtained by fMRI are closely correlated with invasive procedures such as electrical stimulation mapping or the intracarotid amobarbital test. However, language fMRI is not used routinely, because postprocessing is time-consuming. We utilized a real-time analysis software installed directly on the MR console computer and SPM99 as reference postprocessing software. We assessed the reliability of the immediate determination of language dominance based on individual activation maps by comparing the results of the visual analysis of images derived from conventional postprocessing with those produced by the real-time tool. All images were rated independently by six senior neurologists blinded to other data. We validated the robustness of the real-time method statistically by comparing global and regional lateralization indices derived from real-time and postprocessing analysis. Functional MRI was performed with a standard 1.5-T whole-body scanner. Brain activity was contrasted between an alternating semantic judgment and letter matching task. Twelve right-handed, healthy control subjects and 12 consecutive patients with drug-resistant, localization-related epilepsy were investigated. The semantic condition induced almost invariably left hemispheric activations in Broca's area, the premotor cortex, the dorsolateral prefrontal cortex, and the temporoparietal region. Although real-time analysis reduced noise less effectively than SPM99, visual ratings and lateralization indices produced highly concordant results with both methods. In conclusion, real-time fMRI, as used here, allowed reliable language lateralization and mapping in less than 15 min during routine clinical MRI investigation with no need for postprocessing.
- Published
- 2001
20. Cerebral tuberculoma 11 years after renal transplantation
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Heinz-Günter Sieberth, Jürgen Reul, Christian Mrowka, and Bernhard Heintz
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Adult ,Male ,medicine.medical_specialty ,Kidney ,Tuberculosis ,Time Factors ,business.industry ,Urinary system ,medicine.disease ,Kidney Transplantation ,Surgery ,Transplantation ,medicine.anatomical_structure ,Tuberculoma, Intracranial ,Nephrology ,medicine ,Living Donors ,Humans ,Tuberculoma ,business ,Complication ,Ethambutol ,medicine.drug ,Kidney disease - Abstract
A case of cerebral tuberculoma in a 39-year-old patient who had received a renal graft from a living related donor 11 years previously is reported. The patient had a major seizure, progressive psychiatric signs and fever 5 days prior to admission. The clinical history suggested a neurological cause and rapid diagnosis of a cerebral tuberculoma was made by a computed tomography-guided stereotactic puncture of a space-occupying cerebral lesion. The aspirated pus contained Mycobacterium tuberculosis. Anti-tuberculous therapy with isoniacid, rifampicin, ethambutol and pyracinamide was administered. Transplant function deteriorated and the patient died due to intractable septicemia with multiorgan failure from pulmonary infection dissemination and additional urinary tract infection with atypical mycobacteria. The chance for a benign clinical course necessitates vigorous procedures for an early diagnosis of cerebral infections in renal transplant recipients with neurological/psychiatric signs.
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- 1998
21. Endovascular coil embolization of microsurgically produced experimental bifurcation aneurysms in rabbits
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Joachim Weis, Jürgen Reul, Uwe Spetzger, Helmut Bertalanffy, and M. Joachim Gilsbach
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Carotid Artery Diseases ,medicine.medical_specialty ,Subarachnoid hemorrhage ,medicine.medical_treatment ,Hemodynamics ,Anastomosis ,Aneurysm ,Chinchilla ,Occlusion ,medicine ,Animals ,cardiovascular diseases ,Embolization ,business.industry ,Vascular disease ,Intracranial Aneurysm ,medicine.disease ,Embolization, Therapeutic ,Disease Models, Animal ,medicine.anatomical_structure ,cardiovascular system ,Surgery ,Neurology (clinical) ,Radiology ,Rabbits ,business ,Vascular Surgical Procedures ,Artery - Abstract
BACKGROUND Endovascular treatment of cerebral aneurysms is a relatively new method, since only a few animal models and data are available. The present experimental study was performed in order to establish an appropriate aneurysm animal model, to determine the rate of permanent occlusion, and to correlate radiologic and morphologic findings. METHODS End-to-side anastomoses of both common carotid arteries were performed microsurgically in 53 chinchilla rabbits. Venous pouches were adapted into the newly created bifurcation, resulting in berry-shaped aneurysms comparable to those in humans with regard to size and hemodynamics. Platinum and tungsten coils were used for endovascular embolization. The embolized aneurysms were investigated radiologically and morphologically. RESULTS Twenty-three carotid bifurcation aneurysms remained for testing endovascular therapeutic approaches. The morphologic examinations of 13 embolized aneurysms revealed in no instance a complete obliteration, even in the three cases that were considered completely embolized according to angiographic criteria. CONCLUSIONS The present animal model is an optimal tool for endovascular research. Analysis of the results of coil obliteration revealed a considerable discrepancy between radiologic and pathologic findings. The radiologic degree of aneurysm occlusion was overestimated.
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- 1998
22. In Vivo Voxel-Based Morphometry in Multiple System Atrophy of the Cerebellar Type
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Karsten Specht, Michael Abele, Jürgen Reul, Thomas Klockgether, Ullrich Wüllner, and Martina Minnerop
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Male ,Pathology ,medicine.medical_specialty ,Cerebellum ,Pyramidal Tracts ,computer.software_genre ,Stereotaxic Techniques ,White matter ,Arts and Humanities (miscellaneous) ,Cerebellar Diseases ,Voxel ,Image Processing, Computer-Assisted ,medicine ,Humans ,medicine.diagnostic_test ,Magnetic resonance imaging ,Voxel-based morphometry ,Anatomy ,Middle Aged ,Multiple System Atrophy ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,nervous system ,Cerebellar peduncle ,Stereotaxic technique ,Corticospinal tract ,Female ,Neurology (clinical) ,Psychology ,computer ,Brain Stem - Abstract
Background Multiple system atrophy (MSA) is a sporadic neurodegenerative disease. According to the clinical presentation a parkinsonian type and a cerebellar type (MSA-C) are distinguished. Objective To study the morphological alterations of MSA-C–affected brains in vivo using voxel-based morphometric analysis of magnetic resonance images. Setting University hospital. Patients Fourteen patients (5 men and 9 women) with MSA-C (mean age [SD], 59.4 [7.4] years; mean [SD] disease duration, 3.7 [1.4] years) and 13 healthy control subjects (5 men and 8 women) (mean [SD] age, 55.1 [6.9] years) were studied. Methods T1-weighted magnetic resonance images were normalized to a common stereotaxic space and segmented into gray and white matter. Data were analyzed using statistical parametric mapping (SPM99). Results Gray matter was reduced in the brainstem and the anterior lobe of the cerebellum. Reduction of white matter was observed in the middle cerebellar peduncles, cerebellar white matter, and brainstem. The inverted comparison revealed an increase of white matter density along the pyramidal tracts. Conclusions Voxel-based morphometry revealed a significant loss of cerebellar and brainstem tissue in MSA-C. It allowed a precise anatomical localization and a distinction between gray and white matter densities. In addition, our data point to a particular involvement of the pyramidal tract in MSA-C.
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- 2003
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23. Wissenschaftler aus der Kriegskindergeneration als Zeitzeugen
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Peter Maser, Konrad Jarausch, Jürgen Reulecke, Barbara Stambolis, and Heide Glaesmer
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History (General) and history of Europe ,Political science - Abstract
The here documented panel debate goes back to a public evening event during a congress in Leipzig in November 2015 on “Childhood in the Second World War”. Three renowned scientists from the generation of Second World War children, born in the years 1940 to 1943, were invited. In conversation with Barbara Stambolis and hosted by Heide Glaesmer, Peter Maser, Konrad Jarausch and Jürgen Reulecke discuss in retrospect what it means to have been a war child. They devote themselves to generational impressions and explore the connection between personal experiences and their research as well as their social commitment. They formulate thoughtful reflections on transgenerational dimensions and current effects of war and experiences of violence. It seemed to be of particular interest to what extent experiences of one’s own are important for the current international comparative research of World War II children.
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- 2018
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24. Functional brain images of the use of partial advance visual information
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Jürgen Fell, Jürgen Reul, Guillén Fernández, Armin de Greiff, Christian E. Elger, Jürgen Ruhlmann, and Peter Klaver
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Functional brain ,Neurology ,Cognitive Neuroscience ,Brain morphometry ,Psychology ,Brain mapping ,Neuroscience - Published
- 2001
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25. A non-verbal Stroop paradigm specialized for functional neuroimaging
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Peter Falkai, Jürgen Reul, Christian Paul Stracke, Kai Vogeley, and Patrick Bussfeld
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Nonverbal communication ,Stroop Paradigm ,Neurology ,Functional neuroimaging ,Cognitive Neuroscience ,Psychology ,Cognitive psychology - Published
- 2000
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26. Consultants for the American Journal aof Nephrology 1998
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Jesus Calviño, Matthew J. Arduino, Gianna Mastroianni Kirsztajn, Yoshiki Sekijima, Christian Mrowka, Shigeru Nakano, J Baltar, Atsushi Horiuchi, Masao Kanauchi, Kendo Kiyosawa, Toshio Kakihara, Kozo Hishimoto, Hirofumi Hasegawa, M. Lucia Ferraz, Daniel Novoa, Elena Pintos, Michael H. Schwenk, Bernhard Heintz, Mark E. Williams, Zora Krivosiková, Toshikazu Kigoshi, Dolores Güimil, Kamlesh Patel, Eduardo Silva, Monique Delorme, Takashi Ohno, Heinz-Günter Sieberth, Edward Kessler, Takafumi Matsumoto, Edmundo P.A. Lopes, Masayuki Iwano, Koji Suzuki, Ling-Yoeu Yang, Wei-Perng Chen, Jürgen Reul, Victor Arcocha, Javier Mardaras, Ann Chen, Ching-Yuang Lin, Chaim Charytan, J Alvarez-Grande, Bahar Bastani, Wolfgang Fierlbeck, August Heidland, Toshihiro Takao, Y.F. Wang, Michele H. Mokrzycki, Elise M. Jochimsen, David Galli, Kazuhiro Dohi, Thomas R. Welch, Johanne Ismaïl, Tohru Umekawa, Satoru Yonekawa, Katarína Šebeková, Toru Yamaguchi, William R. Jarvis, Yuichi Kobayashi, Alexander S. Goldfarb-Rumyantzev, Anne M. Torres, Aparecido B. Pereira, Atsushi Tanaka, Ricardo Sesso, Manabu Takei, Jose A. Diaz-Buxo, Hiroshi Hayakawa, Ahmed Shafik, Shu-ichi Ikeda, Hiroaki Sato, Makoto Uchiyama, Leonard P. Caccamo, Tung-Po Huang, Shuichi Yamaura, Katsuhito Miyazawa, Atsushi Kubo, Bruce Spinowitz, Atsushi Sasaoka, Brenda P. Youngblood, Ryuzo Tsugawa, Hideyuki Kurioka, C.J. Chang, Toshio Yanagihara, Wakako Nanamiya, Lucila M.V. Lopes, Koji Nishiya, XoseM. Lens, Francisco Ortega, Chamberlain I. Obialo, Mika Sakaguchi, Hiroyuki Ito, Leszek Pączek, Teresa Cordal, Elizabeth Czyziw, Tomomasa Oguchi, Hisao Tanaka, Takashi Kurita, Loretta Carson, Than N. Oo, Charles Frenette, Michael C. Braun, Fumio Kurogouchi, T oshiya Takeda, Masanori Hara, Nathan P. Ritchey, Akio Imada, Barbara A. Erickson, Eiji Hirata, J. Dämmrich, A. Laures, Dianne Carter, Kazuhiko Hora, Junya Onozuka, Sonia M. Aguero, Eiichirou Mawatari, Ramón Peces, Jerome I. Tokars, Shiroshi Kitagawa, Mary Gellens, Rafael Romero, Kenzo Uchida, Yasuhiro Akai, Beverly Hernandez, Ichiro Iwamoto, Hiroaki Chikazawa, Kimbroe J. Carter, Rafael A. Navascués, Stephen Lapierre, Domingo Sanchez-Guisande, and Frank Castro
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Nephrology ,medicine.medical_specialty ,business.industry ,Family medicine ,Internal medicine ,medicine ,business - Published
- 1998
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27. Erfahrungen mit gesellschafts- und kapitalmarktrechtlichen Maßnahmen zur Verbesserung der Eigenkapitalausstattung der Unternehmen in Frankreich
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Jürgen Reul
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- 1986
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28. Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI
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Indira Tendolkar, Jürgen Ruhlmann, Markus Reuber, Christian E. Elger, Susanne Weis, Juergen Fell, Jürgen Reul, Guillén Fernández, Karsten Specht, and Peter Klaver
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Intraclass correlation ,Audiology ,Lateralization of brain function ,Correlation ,Postoperative Complications ,Cognitive neurosciences [UMCN 3.2] ,Preoperative Care ,Determinants in Health and Disease [EBP 1] ,medicine ,Humans ,Epilepsy surgery ,Prefrontal cortex ,Dominance, Cerebral ,Language ,Reproducibility ,Brain Mapping ,Language Disorders ,Language Tests ,Reproducibility of Results ,Middle Aged ,Magnetic Resonance Imaging ,Semantics ,Functional imaging ,Laterality ,Female ,Neurology (clinical) ,Epilepsies, Partial ,Psychology ,Neuroscience - Abstract
Item does not contain fulltext BACKGROUND: fMRI is becoming a standard tool for the presurgical lateralization and mapping of brain areas involved in language processing. However, its within-subject reproducibility has yet to be fully explored. OBJECTIVE: To evaluate within-test and test-retest reliability of language fMRI in consecutive patients undergoing evaluation for epilepsy surgery. METHODS: Thirty-four unselected patients were investigated once (within-test reliability) and 12 patients twice (test-retest reliability). The imaging series consisted of an alternating 25-second synonym judgment condition with a 25-second letter-matching condition repeated 15 times. Reproducibility of activation maps of the first and second half of session 1 or activation maps of sessions 1 and 2 was evaluated by comparing one global and three regional lateralization indexes (Broca's area, remaining prefrontal cortex, temporoparietal area) and on a voxel-by-voxel basis (intraclass correlation coefficient, percentage overlap, correlation of t-values). RESULTS: Global and regional language lateralization was achieved with high reliability within and across sessions. Reproducibility was evenly distributed across both hemispheres but not within each hemisphere. Frontal activations were more reliable than temporoparietal ones. Depending on the statistical threshold chosen, the voxel-by-voxel analysis revealed a mean overlap of activations derived from the first and second investigation of up to 48.9%. CONCLUSION: Language fMRI proved sufficiently reliable for the determination of global and regional lateralization of language representation in individual unselected patients with epilepsy.
29. The role of the right inferior parietal lobule in the calculation of saccade amplitude: An fMRI study
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Jürgen Reul, Klaus Hoenig, Frank Jessen, Nikolaus Freymann, Reinhard Heun, Michael Wagner, and Dirk Oliver Granath
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Neurology ,Right inferior parietal lobule ,Cognitive Neuroscience ,Saccade amplitude ,Psychology ,Neuroscience
30. Laterality of auditory perception
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Karsten Specht, C. Paul Stracke, and Jürgen Reul
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Auditory perception ,medicine.medical_specialty ,Neurology ,Cognitive Neuroscience ,Perception ,media_common.quotation_subject ,Sensation ,Laterality ,medicine ,Audiology ,Psychology ,media_common
31. Clinical use of real-time fMRI in the surgery
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Karsten Specht, Jürgen Reul, C. Paul Stracke, and Markus Scheffler
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medicine.medical_specialty ,Neurology ,business.industry ,Cognitive Neuroscience ,medicine ,Radiology ,business
32. Experiences and applicability of presurgical real-time fMRI
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Jürgen Reul, Karsten Specht, M. Scheffler, and J. Reinartz
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03 medical and health sciences ,0302 clinical medicine ,Radiological and Ultrasound Technology ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,030218 nuclear medicine & medical imaging
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