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7. Neither MRI, CT nor US is superior to diagnose tumors in the salivary glands – an extended case study

Author

Stoll Wolfgang, Kloska Stephan, Jörg Sabine, Rudack Claudia, and Thiede Oliver

Subjects
Specialties of internal medicine, RC581-951
Abstract

Abstract Objectives Ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) are the most common radiological procedures for the diagnosis of tumor-like lesions of the salivary glands. The aim of the present study was to determine whether MRI or CT provide additional information besides that delivered by US. Study design/Methods 109 patients with a tumor-like lesion of the salivary glands underwent surgery. MRI and CT were arranged in 73 and in 40 patients respectively, whereas all 109 patients were prospectively diagnosed by US. The results of CT, MRI and US were compared with the histological outcome. Furthermore, the recent rise in the number of CT and MRI studies was investigated. Results On CT and MRI, there was no rise in the percentage of malignant tumors or advanced surgical procedures. In respect of the radiological assessment of the lesion (benign/malignant) and the correct diagnosis, CT, MRI and US were comparable in terms of sensitivity, specificity and accuracy. No significant difference was found in the Chi-square test (p > 0.05). Conclusion The evaluation of the preoperative results of CT, MRI and US revealed no advantage for CT or MRI; these procedures are only required in specific cases. An update or revision of the current preoperative diagnostic management is deemed necessary.

Published
2007
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13. Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis

Author

Dorhoi, Anca, Nouailles, Geraldine, Jörg, Sabine, Hagens, Kristine, Heinemann, Ellen, Pradl, Lydia, Oberbeck-Müller, Dagmar, Duque-Correa, Maria Adelaida, Reece, Stephen T., Ruland, Jürgen, Brosch, Roland, Tschopp, Jürg, Gross, Olaf, and Kaufmann, Stefan H. E.

Subjects
Homeodomain Proteins, Mice, Knockout, Virulence, integumentary system, Inflammasomes, Macrophages, Interleukin-1beta, Mycobacterium tuberculosis, respiratory system, Vaccines, Attenuated, Mice, Inbred C57BL, Disease Models, Animal, Mice, Proto-Oncogene Proteins, NLR Family, Pyrin Domain-Containing 3 Protein, ESX-1 secretion system, Inflammasome, IL-1β, NLRP3, Disease Progression, Animals, Humans, Disease Susceptibility, Carrier Proteins, Lung, Tuberculosis, Pulmonary, Transcription Factors
Abstract

As a hallmark of tuberculosis (TB), Mycobacterium tuberculosis (MTB) induces granulomatous lung lesions and systemic inflammatory responses during active disease. Molecular regulation of inflammation is associated with inflammasome assembly. We determined the extent to which MTB triggers inflammasome activation and how this impacts on the severity of TB in a mouse model. MTB stimulated release of mature IL-1β in macrophages while attenuated M. bovis BCG failed to do so. Tubercle bacilli specifically activated the NLRP3 inflammasome and this propensity was strictly controlled by the virulence-associated RD1 locus of MTB. However, Nlrp3-deficient mice controlled pulmonary TB, a feature correlated with NLRP3-independent production of IL-1β in infected lungs. Our studies demonstrate that MTB activates the NLRP3 inflammasome in macrophages in an ESX-1-dependent manner. However, during TB, MTB promotes NLRP3- and caspase-1-independent IL-1β release in myeloid cells recruited to lung parenchyma and thus overcomes NLRP3 deficiency in vivo in experimental models.

Published
2012

15. Type I IFN signaling triggers immunopathology in tuberculosis‐susceptible mice by modulating lung phagocyte dynamics

Author

Dorhoi, Anca, primary, Yeremeev, Vladimir, additional, Nouailles, Geraldine, additional, Weiner, January, additional, Jörg, Sabine, additional, Heinemann, Ellen, additional, Oberbeck‐Müller, Dagmar, additional, Knaul, Julia K., additional, Vogelzang, Alexis, additional, Reece, Stephen T., additional, Hahnke, Karin, additional, Mollenkopf, Hans‐Joachim, additional, Brinkmann, Volker, additional, and Kaufmann, Stefan H. E., additional

Published
2014
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16. Impact of inducible co-stimulatory molecule (ICOS) on T-cell responses and protection against Mycobacterium tuberculosis infection

Author

Nouailles, Geraldine, primary, Day, Tracey A., additional, Kuhlmann, Stefanie, additional, Loewe, Delia, additional, Dorhoi, Anca, additional, Gamradt, Pia, additional, Hurwitz, Robert, additional, Jörg, Sabine, additional, Pradl, Lydia, additional, Hutloff, Andreas, additional, Koch, Markus, additional, Kursar, Mischo, additional, and Kaufmann, Stefan H. E., additional

Published
2011
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17. Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis

Author

Day, Tracey A., primary, Koch, Markus, additional, Nouailles, Geraldine, additional, Jacobsen, Marc, additional, Kosmiadi, George A., additional, Miekley, Delia, additional, Kuhlmann, Stefanie, additional, Jörg, Sabine, additional, Gamradt, Pia, additional, Mollenkopf, Hans-Joachim, additional, Hurwitz, Robert, additional, Reece, Stephen T., additional, Kaufmann, Stefan H. E., additional, and Kursar, Mischo, additional

Published
2010
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22. Cell-Wall Alterations as an Attribute of Mycobacterium tuberculosis in Latent Infection.

Author

Seiier, Peter, Ulrichs, Timo, Bandermann, Silke, Pradl, Lydia, Jörg, Sabine, Krenn, Veit, Morawietz, Lars, Kaufmann, Stetan H. E., and Aichele, Peter

Subjects
MYCOBACTERIAL diseases, ZIEHL-Neelsen stain, MYCOBACTERIA identification, MYCOBACTERIUM tuberculosis, DRUG therapy
Abstract

Ziehl-Neelsen (ZN) staining is the key technique for diagnosis of mycobacterial infections; however, a high percentage of patients exhibit positive signs of tuberculosis, as indicated by pathology, culture of mycobacteria, and polymerasechain- reaction analysis, and yet show negative results on ZN staining. In this report we present evidence that such ZN-negative specimens represent Mycobacterium tuberculosis bacilli in a dormant state with distinct cell-wall alterations: the classical cell-wall composition-dependent ZN staining of M. tuberculosis in lung sections gradually discontinued with persistence of infection, both in mice and in human patients; in contrast, detection of mycobacteria by cell-wallcomposition- independent staining using a polyclonal anti-M. bovis Bacille-Calmette-Guérin serum continued with persistence of infection. These findings have important implications for diagnosis, as well as for both chemotherapy and development of vaccine strategies. [ABSTRACT FROM AUTHOR]

Published
2003
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24. German media books

Author

Silberman, Alphons, primary, Hertwig, Jens A., additional, Schbberl, Oswald, additional, Eilers, Franz Josef, additional, Gesamtkonzeption, Medien, additional, Breun, Dieter, additional, Wernecke, Klaus, additional, Heller, Peter, additional, Liedtke, Rudiger, additional, Brummond, Peter, additional, Schwindt, Peter, additional, Gross, Heinz-Willi, additional, Koerner, Christine B., additional, Hagen, Manfred, additional, Kleinstuber, Hans J., additional, Kübler, Friedrich, additional, Ronneberger, Franz, additional, Meister, Ulla, additional, Reith, Manuela, additional, Geisler, Michael, additional, Zerges, Kristina, additional, Strassner, Erich, additional, Wosnitza, Andreas-Rudolf, additional, Jörg, Sabine, additional, Hartmann-Laugs, Petra S., additional, John Goss, A., additional, Bentele, Günter, additional, Ruoff, Robert, additional, Berg, Klaus, additional, Kiefer, Marie-Luise, additional, Walker, Horst O., additional, and Fischer, Heinz-Dietrich, additional

Published
1983
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