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15 results on '"Jánosi, Tibor Z."'

2. Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease

Author

Barabás, Klaudia, primary, Kobolák, Julianna, additional, Godó, Soma, additional, Kovács, Tamás, additional, Ernszt, Dávid, additional, Kecskés, Miklós, additional, Varga, Csaba, additional, Jánosi, Tibor Z., additional, Fujiwara, Takahiro, additional, Kusumi, Akihiro, additional, Téglási, Annamária, additional, Dinnyés, András, additional, and Ábrahám, István M., additional

Published
2021
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3. Single-Molecule Imaging Reveals Rapid Estradiol Action on the Surface Movement of AMPA Receptors in Live Neurons

Author

Godó, Soma, primary, Barabás, Klaudia, additional, Lengyel, Ferenc, additional, Ernszt, Dávid, additional, Kovács, Tamás, additional, Kecskés, Miklós, additional, Varga, Csaba, additional, Jánosi, Tibor Z., additional, Makkai, Géza, additional, Kovács, Gergely, additional, Orsolits, Barbara, additional, Fujiwara, Takahiro, additional, Kusumi, Akihiro, additional, and Ábrahám, István M., additional

Published
2021
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6. Live cell imaging of single neurotrophin receptor molecules on human neuron in Alzheimer’s disease

Author

Barabás, Klaudia, primary, Kobolák, Julianna, additional, Godó, Soma, additional, Ernszt, Dávid, additional, Kecskés, Miklós, additional, Varga, Csaba, additional, Kardos, József, additional, Jánosi, Tibor Z., additional, Fujiwara, Takahiro, additional, Kusumi, Akihiro, additional, Téglási, Annamária, additional, Dinnyés, András, additional, and Ábrahám, István M., additional

Published
2020
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7. Single-molecule analysis reveals the rapid effect of estradiol on the surface movement of AMPAR in live neurons

Author

Godó, Soma, primary, Barabás, Klaudia, additional, Lengyel, Ferenc, additional, Ernszt, Dávid, additional, Kovács, Tamás, additional, Kecskés, Miklós, additional, Varga, Csaba, additional, Jánosi, Tibor Z., additional, Kovács, Gergely, additional, Orsolits, Barbara, additional, Fujiwara, Takahiro, additional, Kusumi, Akihiro, additional, and Ábrahám, István M., additional

Published
2019
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8. Direct Observation of Transition from Solid-State to Molecular-Like Optical Properties in Ultrasmall Silicon Carbide Nanoparticles

Author

Beke, David, primary, Fučíková, Anna, additional, Jánosi, Tibor Z., additional, Károlyházy, Gyula, additional, Somogyi, Bálint, additional, Lenk, Sándor, additional, Krafcsik, Olga, additional, Czigány, Zsolt, additional, Erostyák, János, additional, Kamarás, Katalin, additional, Valenta, Jan, additional, and Gali, Adam, additional

Published
2018
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14. Identification of Luminescence Centers in Molecular-Sized Silicon Carbide Nanocrystals

Author

Beke, David, Jánosi, Tibor Z, Somogyi, Bálint, Major, Dániel Á., Szekrényes, Zsolt, Erostyák, János, Kamarás, Katalin, and Gali, Adam

Abstract

Understanding the fluorescence of complex systems such as small nanocrystals with various surface terminations in solution is still a scientific challenge. Here we show that the combination of advanced time-resolved spectroscopy and ab initio simulations, aided by surface engineering, is able to identify the luminescence centers of such complex systems. Fluorescent water-soluble silicon carbide (SiC) nanocrystals have been previously identified as complex molecular systems of silicon, carbon, oxygen, and hydrogen held together by covalent bonds that made the identification of their luminescence centers unambiguous. The aqueous solutions of molecular-sized SiC nanocrystals are exceedingly promising candidates to realize bioinert nonperturbative fluorescent nanoparticles for in vivo bioimaging, and thus the identification of their luminescent centers is of immediate interest. Here we present identification of two emission centers of this complex system: surface groups involving carbon–oxygen bonds and a defect consisting of silicon–oxygen bonds that becomes the dominant pathway for radiative decay after total reduction of the surface. The identification of these luminescent centers reconciles previous experimental results on the surface and pH-dependent emission of SiC nanocrystals and helps design optimized fluorophores and nanosensors for in vivo bioimaging.

Published
2016
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15. Mechanisms for lung function impairment and airway hyperresponsiveness following chronic hypoxia in rats.

Author

Habre W, Jánosi TZ, Fontao F, Meyers C, Albu G, Pache JC, and Peták F

Subjects
Animals, In Vitro Techniques, Lung drug effects, Lung pathology, Lung Volume Measurements, Methacholine Chloride pharmacology, Rats, Rats, Sprague-Dawley, Respiratory Mechanics drug effects, Bronchial Hyperreactivity complications, Bronchial Hyperreactivity physiopathology, Hypoxia complications, Hypoxia physiopathology, Lung physiopathology
Abstract

Although chronic normobaric hypoxia (CH) alters lung function, its potential to induce bronchial hyperreactivity (BHR) is still controversial. Thus the effects of CH on airway and tissue mechanics separately and changes in lung responsiveness to methacholine (MCh) were investigated. To clarify the mechanisms, mechanical changes were related to end-expiratory lung volume (EELV), in vivo results were compared with those in vitro, and lung histology was assessed. EELV was measured plethysmographically in two groups of rats exposed to 21 days of CH (11% O(2)) or to normoxia. Total respiratory impedance was measured under baseline conditions and following intravenous MCh challenges (2-18 microg x kg(-1) x min(-1)). The lungs were then excised and perfused, and the pulmonary input impedance was measured, while MCh provocations were repeated under a pulmonary capillary pressure of 5, 10, and 15 mmHg. Airway resistance, tissue damping, and elastance were extracted from the respiratory impedance and pulmonary input impedance spectra. The increases in EELV following CH were associated with decreases in airway resistance, whereas tissue damping and elastance remained unaffected. CH led to the development of severe BHR to MCh (206 +/- 30 vs. 95 +/- 24%, P < 0.001), which was not detectable when the same lungs were studied in vitro at any pulmonary capillary pressure levels maintained. Histology revealed pulmonary arterial vascular remodeling with overexpression of alpha-smooth muscle actin antibody in the bronchial wall. These findings suggest that, despite the counterbalancing effect of the increased EELV, BHR develops following CH, only in the presence of intact autonomous nervous system. Thus neural control plays a major role in the changes in the basal lung mechanics and responsiveness following CH.

Published
2010
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