36 results on '"J, Motter"'
Search Results
2. Impacts of the 2018 M7.1 Anchorage earthquake on schools
- Author
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Janise Rodgers, Wael M. Hassan, Christopher J. Motter, and John D. Thornley
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021110 strategic, defence & security studies ,Geophysics ,Geography ,Preparedness ,education ,0211 other engineering and technologies ,Forensic engineering ,02 engineering and technology ,010502 geochemistry & geophysics ,Geotechnical Engineering and Engineering Geology ,01 natural sciences ,0105 earth and related environmental sciences - Abstract
The 2018 M7.1 Anchorage earthquake damaged over 120 schools in the Anchorage and Matanuska-Susitna (Mat-Su) School Districts. Many remained closed for a week or more for cleanup and repairs, primarily due to nonstructural damage. Major structural damage occurred in three of 132 school buildings across both districts, and a number of additional schools had minor to moderate damage. Most observed damage was to nonstructural components, including suspended ceilings, lighting, architectural finishes, building utility systems, and equipment. Middle and high schools were in session at the time of the earthquake. Despite ceiling damage and fallen ceiling tiles, books, and supplies (heavy furniture was anchored) and objects swinging from the ceiling, both districts reported very few injuries. Statements by the school districts and administrators, media reports, and available video indicate that most students dropped, covered, and held on as practiced in regular drills. The combination of life-safety structural performance (with a few exceptions) due in part to moderate shaking, as well as anchoring of heavy furnishings, and student preparedness and drills to practice protective action, appears to have protected students. Both districts’ experiences provide evidence that school seismic safety programs are valuable, even if efforts to mitigate risks from older, vulnerable schools are in process and more work remains.
- Published
- 2021
3. Seismic loss analysis of buildings with post-tensioned cross-laminated timber walls
- Author
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Christopher J. Motter, Adam R. Phillips, J. Daniel Dolan, Alex W. Wilson, and Ji Yun Lee
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021110 strategic, defence & security studies ,Earthquake engineering ,business.industry ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Structural engineering ,Geotechnical Engineering and Engineering Geology ,0201 civil engineering ,Seismic analysis ,Geophysics ,Cross laminated timber ,business ,Geology - Abstract
The FEMA P-58 performance-based earthquake engineering methodology was used to assess the economic losses associated with earthquake damage to nonstructural components of two prototype buildings with post-tensioned cross-laminated timber rocking walls. A suite of 22 far-field ground motions were used for nonlinear time history (NLTH) analysis. Truncated incremental dynamic analysis was used to scale the ground motions, and results of the NLTH analyses were used to develop cumulative distribution functions for inter-story drift and peak floor accelerations. The economic factors assessed in the risk analysis included the expected repair cost with respect to spectral acceleration, the probability of exceeding an expected repair cost for selected time periods, and the expected annual loss over different time periods considering various discount factors. It was determined that the ratio of nonstructural repair cost to total building cost at the design earthquake and maximum considered earthquake was lower for the low-rise building than the mid-rise building. However, the probability of nonstructural damage at the service-level earthquake was lower for the mid-rise building than the low-rise building.
- Published
- 2020
4. QUANTIFYING THE EFFECTS OF EPOXY REPAIR OF REINFORCED CONCRETE PLASTIC HINGES
- Author
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Christopher J. Motter, Kai J. Marder, Kenneth J. Elwood, and G. Charles Clifton
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021110 strategic, defence & security studies ,Materials science ,business.industry ,0211 other engineering and technologies ,Hinge ,Stiffness ,020101 civil engineering ,02 engineering and technology ,Structural engineering ,Epoxy ,Geotechnical Engineering and Engineering Geology ,Reinforced concrete ,0201 civil engineering ,visual_art ,Plastic hinge ,medicine ,visual_art.visual_art_medium ,medicine.symptom ,Deformation (engineering) ,business ,Beam (structure) ,Civil and Structural Engineering ,Test data - Abstract
Modern reinforced concrete structures are typically designed to form plastic hinges during strong earthquakes. In post-earthquake situations, repair of moderate plastic hinging damage can be undertaken by filling the crack system with epoxy resin and reconstituting spalled cover concrete. This study uses available experimental test data, including three large-scale ductile beams tested by the authors, to investigate the effects of epoxy repair on the structural behaviour of plastic hinges, with a focus on beam elements. Factors that have been neglected in past studies, including the effects of residual deformations at the time of repair, are given special attention. It is found that epoxy-repaired plastic hinges can exhibit different behaviour from identical undamaged components in terms of stiffness, strength, deformation capacity, and axial elongation. Potential explanations for the observed differences in behaviour are given, and recommendations are made for how these differences can be quantified in order to relate the expected response of an epoxy-repaired plastic hinge to the response that would be calculated for an identical undamaged component.
- Published
- 2020
5. Post-earthquake assessment of moderately damaged reinforced concrete plastic hinges
- Author
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G. Charles Clifton, Christopher J. Motter, Kai J. Marder, and Kenneth J. Elwood
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Geophysics ,business.industry ,Hinge ,Structural engineering ,Geotechnical Engineering and Engineering Geology ,Reinforced concrete ,business ,Geology - Abstract
Modern reinforced concrete buildings are often designed to dissipate energy during strong earthquakes by permitting the controlled formation of plastic hinges. Plastic hinges require assessment of residual capacity in post-earthquake situations. However, few past studies have investigated this topic, and results from experiments focused on undamaged structures are not always transferable to post-earthquake situations. Data from an experimental program, in which both cyclic and earthquake-type loadings were applied to nominally identical reinforced concrete beams, are used to investigate the relationship between residual crack widths and rotation demands. Assessment of the peak deformation demands incurred during a damaging earthquake is critical for post-earthquake assessments, but residual crack widths are shown to be dependent on several factors in addition to the peak rotation demand. Non-dimensional metrics capturing the distribution of cracking are proposed as a more informative alternative. The reduction in stiffness that occurs as a result of earthquake-induced plastic hinging damage was also investigated. A proposed model is shown to give a lower-bound estimate of the residual stiffness following arbitrary earthquake-type loadings.
- Published
- 2020
6. Modeling techniques for post-tensioned cross-laminated timber rocking walls
- Author
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Christopher J. Motter, Adam R. Phillips, J. Daniel Dolan, and Alex W. Wilson
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business.industry ,Cross laminated timber ,Structural engineering ,business ,Geology ,Civil and Structural Engineering - Published
- 2019
7. Deformation Capacity Limits for Reinforced Concrete Walls
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Richard Henry, Christopher J. Motter, Kenneth J. Elwood, and Alex Shegay
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Geophysics ,021105 building & construction ,0211 other engineering and technologies ,020101 civil engineering ,Geotechnical engineering ,02 engineering and technology ,Deformation (meteorology) ,Geotechnical Engineering and Engineering Geology ,Reinforced concrete ,Geology ,0201 civil engineering ,Seismic analysis - Abstract
The use of deformation capacity limits is becoming increasingly common in seismic design and assessment of reinforced concrete (RC) walls. Deformation capacity limits for RC walls in existing design and assessment documents are reviewed using a comprehensive database. It is found that the existing models are inconsistent and do not account for variation in deformation capacity with changes in the ratio of neutral axis depth to wall length ( c/ L w) and ratio of transverse reinforcement spacing to longitudinal bar diameter ( s/ d b) at the wall end region. A new mechanics-based model considering strain limits on the concrete and reinforcement is recommended. Concrete compressive strain limits for different levels of wall end region detailing are selected based on curvature ductilities for the walls in the database. Reinforcement tensile strain is limited based on a model for bar buckling. The proposed model, which accounts for c/ L w and s/ d b, is shown to have less dispersion and more accuracy than existing models when compared against experimental data and provides consistency between assessment and design provisions.
- Published
- 2019
8. Seismic Response of Post-Tensioned Cross-Laminated Timber Rocking Wall Buildings
- Author
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Adam R. Phillips, J. Daniel Dolan, Alex W. Wilson, and Christopher J. Motter
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business.industry ,Mechanical Engineering ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Structural engineering ,0201 civil engineering ,Time history ,Flexural strength ,Mechanics of Materials ,021105 building & construction ,Cross laminated timber ,General Materials Science ,business ,Geology ,Civil and Structural Engineering - Abstract
Nonlinear time history analyses were conducted for 5-story and 12-story prototype buildings that used post-tensioned cross-laminated timber rocking walls coupled with U-shaped flexural plat...
- Published
- 2020
9. Seismic Behavior of Nonductile Reinforced Concrete Beam-Column Frame Subassemblies
- Author
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Christopher J. Motter, Richard Henry, Kenneth J. Elwood, and Eyitayo A. Opabola
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021110 strategic, defence & security studies ,Gravity (chemistry) ,business.industry ,Mechanical Engineering ,Frame (networking) ,0211 other engineering and technologies ,Vulnerability ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Structural engineering ,Reinforced concrete ,0201 civil engineering ,Mechanics of Materials ,Beam column ,General Materials Science ,business ,Geology ,Civil and Structural Engineering - Abstract
The 2010–2011 Canterbury Earthquakes in New Zealand highlighted the vulnerability of gravity load resisting reinforced concrete frames in older buildings that do not comply with modern buil...
- Published
- 2019
10. Testing of 17 Identical Ductile Reinforced Concrete Beams with Various Loading Protocols and Boundary Conditions
- Author
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Kenneth J. Elwood, G. Charles Clifton, Christopher J. Motter, and Kai J. Marder
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021110 strategic, defence & security studies ,Materials science ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Reinforced concrete ,Axial elongation ,0201 civil engineering ,Geophysics ,Loading rate ,Boundary value problem ,Composite material ,Beam (structure) - Abstract
A set of tests on 17 large-scale, nominally identical, beam specimens with variations in loading protocol, loading rate, and restraint to axial elongation are described. Three specimens were also repaired by epoxy injection following an initial damaging earthquake loading. This paper provides a detailed description of the test program, and the corresponding data are made available at Design-Safe (DOI: 10.17603/DS2SQ2K). While the primary goal of the test program was to improve the state of knowledge regarding the post-earthquake residual capacity of reinforced concrete plastic hinges in beams, the data are useful for modeling approaches that consider loading rate, plastic hinge elongation, cyclic degradation, and flexure–shear–axial interaction, in addition to investigating the effectiveness of post-earthquake repair techniques by epoxy injection of cracks.
- Published
- 2018
11. Effects of variation in loading protocol on the strength and deformation capacity of ductile reinforced concrete beams
- Author
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Kai J. Marder, Kenneth J. Elwood, Christopher J. Motter, and G. Charles Clifton
- Subjects
021110 strategic, defence & security studies ,Materials science ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Deformation (meteorology) ,Geotechnical Engineering and Engineering Geology ,Reinforced concrete ,0201 civil engineering ,Experimental testing ,Variation (linguistics) ,Earth and Planetary Sciences (miscellaneous) ,Loading rate ,Composite material ,Civil and Structural Engineering - Published
- 2018
12. Seismic performance of repaired lightly-reinforced concrete walls
- Author
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James C. Petch, Matías A. Hube, Richard Henry, Kenneth J. Elwood, Aaron B. Clauson, and Christopher J. Motter
- Subjects
021110 strategic, defence & security studies ,business.industry ,0211 other engineering and technologies ,Stiffness ,020101 civil engineering ,02 engineering and technology ,Structural engineering ,Geotechnical Engineering and Engineering Geology ,Spall ,Reinforced concrete ,0201 civil engineering ,Buckling ,medicine ,Fracture (geology) ,Mortar ,medicine.symptom ,Reinforcement ,business ,Geology ,Civil and Structural Engineering ,Tensile testing - Abstract
As a result of the 2010-2011 Canterbury earthquakes, over 60% of the concrete buildings in the Christchurch Central Business District have been demolished. This experience has highlighted the need to provide guidance on the residual capacity and repairability of earthquake-damaged concrete buildings. As limited testing has been performed on repaired components, this study focuses on the performance of severely-damaged lightly-reinforced concrete walls repaired through replacement of reinforcement and concrete in the damaged region. The damage prior to repair included buckling and fracture of longitudinal reinforcement, crushing and spalling of concrete, and, for one of the two specimens, out-of-plane instability of the gross section. Prior to repairing the wall specimens, tensile testing of reinforcement with welded connections was conducted to verify acceptable performance of welds suitable for reinstating the damaged reinforcement. Repairs to the specimens consisted of removal of damaged concrete through either hydro-demolition or jack hammering, followed by cutting and removal of damaged reinforcement and reinstatement of new reinforcement and repair mortar. The two repaired wall specimens were tested using a standard protocol that was identical to that used for one of the two original wall specimens. Aside from a difference in the elastic stiffness, the load-deformation responses of the repaired specimens were similar to that of the originally-tested specimen through to the first loading cycle at 2.0% drift, beyond which strength degradation was more pronounced for the repaired specimens. The overall performance of the repaired walls relative to the original wall indicates that it is feasible to achieve acceptable performance of severely-damaged concrete walls repaired through replacement of reinforcement and concrete in the damaged region.
- Published
- 2017
13. Canadian Surgery Forum 2018: St. John’s, NL Sept. 13–15, 2018
- Author
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S, Jayaraman, L, Lee, J, Mata, R, Droeser, P, Kaneva, S, Liberman, P, Charlebois, B, Stein, G, Fried, L, Feldman, M, Schellenberg, K, Inaba, V, Cheng, J, Bardes, L, Lam, E, Benjamin, K, Matsushima, D, Demetriades, J, Cho, A, Strumwasser, D, Grabo, C, Bir, A, Eastman, N, Orozco, J, Chen, C, Park, T, Kang, J, Jung, J, Elfassy, T, Grantcharov, J, Taylor, M, Stem, D, Yu, S, Chen, S, Fang, S, Gearhart, B, Safar, J, Efron, P, Serrano, S, Parpia, D, McCarty, N, Solis, M, Valencia, S, Jibrael, A, Wei, S, Gallinger, M, Simunovic, A, Hummadi, M, Rabie, M, Al Skaini, H, Shamshad, S, Shah, K, Verhoeff, P, Glen, A, Taheri, B, Min, B, Tsang, V, Fawcett, S, Widder, M, Yang, K, Wanis, O, Gilani, K, Vogt, M, Ott, J, VanKoughnett, C, Vinden, S, Balvardi, E, St Louis, Y, Yousef, A, Toobaie, E, Guadagno, R, Baird, D, Poenaru, A, Kleiman, B, Mador, C, Moulton, E, Lee, C, Li, K, Beyfuss, H, Solomon, N, Sela, V, McAlister, A, Ritter, J, Hallet, M, Tsang, G, Martel, D, Jalink, M, Husien, C, Gu, M, Levine, S, Otiti, J, Nginyangi, C, Yeo, J, Ring, M, Holden, T, Ungi, G, Fichtinger, B, Zevin, B, Fang, J, Dang, S, Karmali, M, Kim, B, Zhang, E, Duceppe, S, Rieder, A, Maeda, A, Okrainec, T, Jackson, F, Kegel, S, Lachance, T, Landry, C, Mueller, S, Joharifard, E, Nyiemah, C, Howe, C, Dobboh, L Gizzie, Kortimai, A, Kabeto, J, Beste, N, Garraway, R, Riviello, S, Hameed, S, Shinde, G, Marcil, S, Prasad, J, Arminan, E, Debru, N, Church, R, Gill, P, Mitchell, M, Delisle, C, Chernos, J, Park, K, Hardy, A, Vergis, M, Guez, D, Hong, J, Koichopolos, R, Hilsden, D, Thompson, F, Myslik, J, Vandeline, R, Leeper, A, Doumouras, S, Govind, S, Valanci, N, Alhassan, T, Wong, N, Nadkarni, S, Chia, D, Seow, D, Carter, L, Ruo, O, Levine, L, Allen, P, Murphy, R, van Heest, F, Saleh, S, Minor, P, Engels, E, Joos, C, Wang, R, Nenshi, M, Meschino, C, Laane, N, Parry, M, Hameed, A, Lacoul, C, Chrystoja, J, Ramjist, R, Sutradhar, L, Lix, N, Baxter, D, Urbach, J, Ahlin, S, Patel, S, Nanji, S, Merchant, K, Lajkosz, S, Brogly, P, Groome, J, Sutherland, G, Liu, T, Crump, M, Bair, A, Karimuddin, A, Peterson, J, Hawel, E, Shlomovitz, I, Habaz, A, Elnahas, N, Alkhamesi, C, Schlachta, G, Akhtar-Danesh, T, Daodu, V, Nguyen, R, Dearden, I, Datta, L, Hampton, A, Kirkpatrick, J, McKee, J, Regehr, P, Brindley, D, Martin, A, LaPorta, L, Gillman, K, DeGirolamo, K, D'Souza, L, Hartford, D, Gray, C, Clarke, R, Wigen, C, Garcia-Ochoa, S, Gray, A, Maciver, J, Van Koughnett, K, Leslie, T, Zwiep, S, Ahn, J, Greenberg, F, Balaa, D, McIsaac, R, Musselman, I, Raiche, L, Williams, H, Moloo, M, Nguyen, D, Naidu, P, Karanicolas, A, Nadler, R, Raskin, V, Khokhotva, R, Poirier, C, Plourde, A, Paré, M, Marchand, M, Leclair, J, Deshaies, P, Hebbard, I, Ratnayake, K, Decker, E, MacIntosh, Z, Najarali, A, Alhusaini, A, McClure, M, Dakouo, R, Behman, A, Nathens, N Look, Hong, P, Pechlivanoglou, K, Lung, P, Simone, E, Schemitsch, L, Chen, L, Rosenkrantz, N, Schuurman, R, George, E, Shavit, A, Pawliwec, Z, Rana, D, Evans, P, Dawe, R, Brown, G, Lefebvre, K, Devenny, D, Héroux, C, Bowman, R, Mimeault, L, Calder, L, Baker, R, Winter, C, Cahill, D, Fergusson, T, Schroeder, K, Kahnamoui, S, Elkheir, F, Farrokhyar, B, Wainman, O, Hershorn, S, Lim, A, Arora, F, Wright, J, Escallon, L, Gotlib, M, Allen, N, Gawad, I, Raîche, G, Jeyakumar, D, Li, M, Aarts, A, Giles, T, Dumitra, R, Alam, J, Fiore, M, Vassiliou, O, Al Busaidi, A, Brobbey, T, Stelfox, T, Chowdhury, J, Kortbeek, C, Ball, N, AlShahwan, S, Fraser, A, Tran, A, Martel, N, Manhas, D, Mannina, A, Behman, B, Haas, A, Fowler, L, Findlay-Shirras, H, Singh, N, Biswanger, A, Gosselin-Tardif, M Abou, Khalil, J Mata, Gutierrez, A, Guigui, L, Ferri, D, Roberts, L, Moore, J, Holcomb, J, Harvin, J, Sadek, P, Belanger, K, Nadeau, K, Mullen, D, Aitkens, K, Foss, D, MacIsaac, S, Zhang, M, Methot, L, Hookey, J, Yates, I, Perelman, E, Saidenberg, S, Khair, J, Lampron, A, Tinmouth, S, Hammond, D, Hochman, M, Lê, R, Rabbani, A, Abou-Setta, R, Zarychanski, B, Elsoh, B, Goldacre, G, Nash, M, Trepanier, N, Wong-Chong, C, Sabapathy, P, Chaudhury, N, Bradley, C, Dakin, N, Holm, W, Henderson, M, Roche, A, Sawka, E, Tang, B, Huang, T, Gimon, R, Rochon, M, Lipson, W, Buie, A, MacLean, E, Lau, V, Mocanu, I, Tavakoli, N, Switzer, C, Tian, C, de Gara, D, Birch, P, Young, C, Chiu, A, Meneghetti, G, Warnock, M, Meloche, O, Panton, A, Istl, A, Gan, P, Colquhoun, R, Habashi, S, Stogryn, J, Metcalfe, K, Clouston, N, Zondervan, K, McLaughlin, J, Springer, J, Lee, N, Amin, M, Caddedu, C, Eskicioglu, A, Warraich, D, Keren, N, Kloos, S, Gregg, R, Mohamed, E, Dixon, R, Rochan, A, Domouras, S, Kelly, I, Yang, S, Forbes, R, Garfinkle, S, Bhatnagar, G, Ghitulescu, C, Vasilevsky, N, Morin, M, Boutros, A, Petrucci, P, Sylla, S, Wexner, G, Sigler, J, Faria, P, Gordon, L, Azoulay, A, Liberman, S, Khorasani, A, de Buck van Overstraeten, E, Kennedy, N, Pecorelli, D, Mouldoveanu, A, Gosselin-Tardiff, J, Chau, F Rouleau, Fournier, P, Bouchard, J Abou, Khalil, J, Motter, J, Mottl, G, Hwang, J, Kelly, G, Nassif, M, Albert, J, Monson, J, McLeod, J, Cha, M, Raval, T, Phang, C, Brown, R, Robertson, F, Letarte, A, Antoun, V, Pelsser, E, Hyun, K, Clouston-Chambers, R, Helewa, S, Candy, Z, Mir, N, Hanna, A, Azin, D, Hirpara, F, Quereshy, C, O'Brien, S, Chadi, S, Punnen, H, Yoon, W, Xiong, H, Stuart, J, Andrews, R, Selvam, S, Wong, W, Hopman, P, MacDonald, F, Dossa, B, Medeiros, C, Keng, S, Acuna, J, Hamid, A, Ghuman, N, Kasteel, D, Buie, T, McMullen, A, Elwi, T, MacLean, H, Wang, F, Coutinho, Q, Le, L, Shack, H, Roy, R, Kennedy, J, Bunn, W, Chung, M, Elmi, E, Wakeam, R, Presutti, S, Keshavjee, T, Cil, D, McCready, V, Cheung, C, Schieman, J, Bailey, G, Nelson, T, Batchelor, S, Grondin, A, Graham, N, Safieddine, S, Johnson, W, Hanna, D, Low, A, Seely, E, Bedard, C, Finley, R, Nayak, D, Lougheed, D, Petsikas, A, Kinio, V Ferreira, Resende, C, Anstee, D, Maziak, S, Gilbert, F, Shamji, S, Sundaresan, P, Villeneuve, J, Ojah, A, Ashrafi, A, Najjar, I, Yamani, S, Sersar, A, Batouk, D, Parente, A, Laliberte, M, McInnis, C, McDonald, Y, Hasnain, K, Yasufuku, T, Waddell, N, Chopra, C, Nicholson-Smith, R, Malthaner, R, Patel, M, Doubova, H, Robaidi, E, Delic, A, Fazekas, K, Hughes, P, Pinkney, Y, Lopez-Hernandez, M, Coret, L, Schneider, J, Agzarian, Y, Shargall, M, Mehta, K, Pearce, V, Gupta, N, Coburn, B, Kidane, K, Hess, C, Compton, J, Ringash, G, Darling, A, Mahar, P, Thomas, J, Vernon, J, Spicer, S, Renaud, J, Seitlinger, Y, Al Lawati, F, Guerrera, P, Falcoz, G, Massard, D, Hylton, J, Huang, S, Turner, D, French, C, Wen, J, Masters, C, Fahim, D, St-Pierre, E, Ruffini, M, Inra, Z, Abdelsattar, S, Cassivi, F, Nichols, D, Wigle, S, Blackmon, K, Shen, S, Gowing, F Sadegh, Beigee, K, Sheikhy, A Abbasi, Dezfouli, T, Schnurr, L, Linkins, M, Crowther, M, de Perrot, S, Uddin, J, Douketis, L, Angka, A, Jeong, M, Sadiq, M, Kilgour, C Tanese, de Souza, M, Kennedy, R, Auer, R, Adam, R, Memeo, D, Goéré, T, Piardi, E, Lermite, O, Turrini, M, Lemke, J, Li, M, Tun-Abraham, R, Hernandez-Alejandro, S, Bennett, F, Navarro, A, Sa Cunha, P, Pessaux, E, Isenberg-Grzeda, J, Kazdan, S, Myrehaug, S, Singh, D, Chan, C, Law, C, Nessim, G, Paull, A, Ibrahim, E, Sabri, S, Rodriguez-Qizilbash, D, Berger-Richardson, R, Younan, J, Hétu, S, Johnson-Obaseki, F, Angarita, Y, Zhang, A, Govindarajan, E, Taylor, Z, Bayat, D, Bischof, A, McCart, S, Sequeira, S, Samman, S, Cornacchi, G, Foster, L, Thabane, S, Thomson, O, Lovrics, S, Martin, P, Lovrics, N, Latchana, L, Davis, Y, Liu, A, Hammad, D, Kagedan, C, Earle, G, Pang, S, Kupper, M, Quan, R, Hsiao, P, Bongers, M, Lustgarten, D, Goldstein, P, Dhar, L, Rotstein, J, Pasternak, J, Nostedt, L, Gibson-Brokop, M, McCall, D, Schiller, S, Mukhi, L, Mack, N, Singh, M, Chanco, A, Hilchie-Pye, C, Kenyon, A, Mathieson, J, Burke, R, Nason, J, Austin, M, Brar, S, Hurton, S, Kong, Y, Xu, M, Thibedeau, W, Cheung, J, Dort, S, Karim, A, Bouchard-Fortier, Y, Jeong, Q, Li, L, Bubis, C, O'Rourke, N, Dharampal, K, Smith, A, Harvey, R, Pashcke, L, Rudmik, S, Chandarana, S, Buac, S, Latosinsky, N, Shahvary, M, Gervais, G, Leblanc, M, Brackstone, K, Guidolin, B, Yaremko, S, Gaede, K, Lynn, A, Kornecki, G, Muscedere, O, Shmuilovich, I, BenNachum, M, Mouawad, N, Gelman, M, Lock, J, Daza, M, Horkoff, F, Sutherland, O, Bathe, M, Moser, J, Shaw, G, Beck, Y, Luo, S, Ahmed, C, Wall, T, Domes, K, Jana, E, Waugh, J, Baird, P, Newell, P, Hansen, M, Gough, E, McArthur, A, Skaro, G, Gauvin, N, Goel, D, Mutabdzic, F, Lambreton, M, Kilcoyne, K, Ang, A, Karachristos, H, Cooper, J, Hoffman, S, Reddy, L, Park, R, Gilbert, R, Shorr, A, Workneh, K, Bertens, J, Abou-Khalil, H, Smith, J, Levy, J, Ellis, B, Bakanisi, M, Sadeghi, S, Michaelson, V, Tandan, M, Marcaccio, D, Dath, M, Connell, A, Bennett, N, Wasey, R, Sorial, S, Macdonald, D, Johnson, D, Klassen, C, Leung, C, Botkin, M, Bahasadri, S, MacLellan, J, Tan, H, Jun, H, Cheah, K, Wong, N, Harvey, A, Smith, S, Cassie, S, Sun, J, Vallis, L, Twells, K, Lester, D, Gregory, W, Sun, F, Raghavji, M, Laffin, J, Bourget-Murray, A, Reso, A, Jarrar, N, Eipe, A, Budiansky, C, Walsh, J, Mamazza, and M, Rashid
- Subjects
Abstracts - Published
- 2018
14. Impact of Axial Load on the Seismic Response of Rectangular Walls
- Author
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Dawn E. Lehman, Kenneth J. Elwood, Alex Shegay, Laura N. Lowes, Christopher J. Motter, and Richard Henry
- Subjects
021110 strategic, defence & security studies ,business.industry ,Mechanical Engineering ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Structural engineering ,0201 civil engineering ,Mechanics of Materials ,Axial load ,General Materials Science ,business ,Geology ,Civil and Structural Engineering - Abstract
Experimental testing was conducted on four large-scale, flexure-yielding walls with rectangular cross sections to investigate the impact of imposed axial load ratio (10, 14, and 20% of axia...
- Published
- 2018
15. Modeling of Reinforced Concrete Two-Way Floor Slab Deflections due to Construction Loading
- Author
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Christopher J. Motter and Andrew Scanlon
- Subjects
Mechanics of Materials ,business.industry ,Deflection (engineering) ,Mechanical Engineering ,General Materials Science ,Building and Construction ,Structural engineering ,Reinforced concrete ,business ,Floor slab ,Geology ,Analytical algorithm ,Civil and Structural Engineering - Abstract
An analytical algorithm was developed to compute the midpanel deflection history for reinforced concrete two-way floor slabs in multistory buildings. Midpanel deflection was determined usin...
- Published
- 2018
16. Reinforced Concrete Structural Walls without Special Boundary Elements
- Author
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John W. Wallace, Saman A. Abdullah, and Christopher J. Motter
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business.industry ,0211 other engineering and technologies ,Boundary (topology) ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Structural engineering ,Reinforced concrete ,0201 civil engineering ,021105 building & construction ,business ,Boundary element method ,Geology ,Civil and Structural Engineering - Published
- 2018
17. Steel-Reinforced Concrete Coupling Beams. I: Testing
- Author
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John W. Wallace, Christopher J. Motter, John Hooper, Ron Klemencic, and David C. Fields
- Subjects
Engineering ,Cantilever ,Bearing (mechanical) ,business.industry ,Embedment ,Mechanical Engineering ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Structural engineering ,Compression (physics) ,Span (engineering) ,0201 civil engineering ,law.invention ,Shear (sheet metal) ,Mechanics of Materials ,law ,021105 building & construction ,Shear wall ,General Materials Science ,business ,Beam (structure) ,Civil and Structural Engineering - Abstract
Structural steel-reinforced concrete (SRC) coupling beams are an alternative to conventional and diagonal rebar-reinforced concrete coupling beams. To address gaps in previous testing that was used to develop design recommendations, four large-scale, flexure-yielding, cantilever SRC coupling beams were embedded, without inclusion of auxiliary transfer bars and bearing plates, into reinforced concrete structural walls. Beams were tested by applying quasi-static, reversed-cyclic shear loading to the coupling beam, and moment and shear to the top of the wall to create cyclic tension and compression fields across the embedment region. The primary test variables were the structural steel section embedment length, beam span length (aspect ratio), quantities of wall boundary longitudinal and transverse reinforcement, and applied wall loading (moment, shear, and axial load). Favorable performance, characterized by minimal pinching and asymmetry in the load-deformation response and concentration of damage ...
- Published
- 2017
18. Steel-Reinforced Concrete Coupling Beams. II: Modeling
- Author
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Christopher J. Motter, John Hooper, David C. Fields, John W. Wallace, and Ron Klemencic
- Subjects
Materials science ,Embedment ,business.industry ,Mechanical Engineering ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Slip (materials science) ,Structural engineering ,Reinforced concrete ,Upper and lower bounds ,0201 civil engineering ,Bond beam ,Coupling beam ,Mechanics of Materials ,021105 building & construction ,Shear wall ,General Materials Science ,business ,Civil and Structural Engineering ,Grade beam - Abstract
Using test results presented in previous studies, design and modeling recommendations for steel-reinforced concrete (SRC) coupling beams are provided for both code-based (prescriptive) design approaches and performance-based design approaches. Procedures for computing both nominal and expected (upper bound) moment and shear strengths are described. For embedment, a capacity design approach is recommended in which the provided embedment strength exceeds the expected beam strength. Two approaches are recommended for determination of effective stiffness, one based on using a rigid beam (for flexure and shear) along with an interface rotational spring, since test results from the literature indicate that the majority of the coupling-beam deformations were associated with interface slip/extension, and an alternative approach where the effective stiffness is based on the beam aspect ratio or beam length. Additional parameters are provided to define deformation capacity at significant strength loss (to c...
- Published
- 2017
19. Effect of surface treatment on the initial bond strength of different luting cements to zirconium oxide ceramic
- Author
-
Frank P. Nothdurft, P. J. Motter, and Peter Pospiech
- Subjects
Dental Stress Analysis ,Cement ,Zirconium ,Materials science ,Zirconium dioxide ,Surface Properties ,Bond strength ,Dental Bonding ,chemistry.chemical_element ,Dental bonding ,Dental Porcelain ,Phosphates ,Resin Cements ,chemistry.chemical_compound ,chemistry ,Silanization ,Shear strength ,Direct shear test ,Composite material ,Shear Strength ,General Dentistry - Abstract
The objective of this study was to compare the shear bond strength to zirconium oxide ceramic of adhesive-phosphate-monomer-containing (APM) and non-APM-containing (nAPM) luting cements after different surface treatments. nAPM cements: Bifix QM, Dual Cement, Duo Cement Plus, Multilink Automix, ParaCem Universal DC, PermaCem Smartmix, RelyX ARC, Variolink Ultra, and Variolink II; APM cements: Panavia EX, Panavia F2.0, and RelyX UniCem. Groups of ten test specimens were each prepared by layering luting cement, using cylindrical Teflon molds, onto differently treated zirconium dioxide discs. The surface treatments were airborne-particle abrasion with 110 mum alumina particles, silica coating (SC) using 30 mum alumina particles modified by silica (Rocatec System) or SC and silanization. Bifix QM and Multilink Automix were used in combination with an additional bonding/priming agent recommended by the manufacturers. After 48 h of water storage, each specimen was subjected to a shear test. Combinations involving APM-containing cements (14.41-23.88 MPa) generally exhibited higher shear bond strength than those without APM (4.29-17.34 MPa). Exceptions were Bifix QM (14.20-25.11 MPa) and Multilink Automix (19.14-23.09 MPa) in combination with system-specific silane or priming agent, which were on the upper end of shear bond strength values. With the use of the Rocatec system, a partially significant increase in shear bond strength could be achieved in nAPM cement. Modified surface treatment modalities increased the bond strength to zirconium oxide, although the most important factor in achieving a strong bond was the selection of a suitable cement. System-specific priming or bonding agents lead to further improvement.
- Published
- 2008
20. Influence of fatigue testing and cementation mode on the load-bearing capability of bovine incisors restored with crowns and zirconium dioxide posts
- Author
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Frank P. Nothdurft, Peter Pospiech, P. J. Motter, and Thomas Schmitt
- Subjects
Dental Stress Analysis ,Materials science ,Composite number ,chemistry.chemical_element ,Composite Resins ,Tooth Fractures ,chemistry.chemical_compound ,Dental porcelain ,Animals ,Composite material ,Cementation ,General Dentistry ,Zirconium ,Polycarboxylate Cement ,Crowns ,Zirconium dioxide ,Chromium Alloys ,Fatigue testing ,Cementation (geology) ,Dental Porcelain ,Post and core ,Resin Cements ,Incisor ,chemistry ,Glass Ionomer Cements ,Cattle ,Zinc Oxide ,Magnesium Oxide ,Post and Core Technique - Abstract
The aim of the study was to evaluate the influence of fatigue and cementation mode on the fracture behavior of endodontically treated bovine incisors restored with zirconium dioxide posts and crowns. Forty-eight endodontically treated bovine primary incisors were restored with zirconium dioxide posts (Cerapost, Brasseler), composite build-ups, and crowns cast from a chromium cobalt alloy. In 16 teeth, each of the posts was cemented conventionally with KetacCem (3M ESPE) or adhesively with Panavia F (Kuraray) or RelyX UniCem (3M ESPE). One-half of the specimens in each group were subjected to thermocycling with 10,000 cycles at 5-55 degrees C and mechanical aging, loading the specimens at an angle of 45 degrees in 1,200,000 cycles with 50 N. Fracture resistance was determined by loading the specimens until fracture at an angle of 45 degrees to the long axis of the teeth. The loading test showed that neither cementation mode nor fatigue testing had an influence on the load bearing capability. Most specimens fractured in a favorable way, independent from the type of cementation.
- Published
- 2008
21. The fracture behavior of premolar teeth with class II cavities restored by both direct composite restorations and endodontic post systems
- Author
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Frank P. Nothdurft, Peter Pospiech, P. J. Motter, Florian Gebhart, Michael Naumann, and E. Seidel
- Subjects
Dental Stress Analysis ,Materials science ,business.industry ,Glass fiber ,Composite number ,Glass ionomer cement ,Fatigue testing ,Dentistry ,Composite Resins ,Post and core ,Statistics, Nonparametric ,Tooth Fractures ,medicine.anatomical_structure ,Root Canal Obturation ,Premolar ,medicine ,Fracture (geology) ,Humans ,Bicuspid ,Dental Restoration Failure ,Dental Cavity Preparation ,business ,General Dentistry ,Post and Core Technique ,Resin cement - Abstract
Purpose The aim of the study was to evaluate the influence of different posts on the fracture load and fracture mode of endodontically treated premolars with class II cavities and direct composite restorations in an ex vivo setting. Methods Forty-eight single-rooted human premolars were endodontically treated and prepared with standardized MO (mesio-occlusal) cavities. Eight teeth each received either no posts or were restored with titanium screws (BKS), glass fiber posts (DentinPost), or quartz fiber posts (DT Light SL). Sixteen teeth were restored with zirconium dioxide posts (CeraPost). BKS-screws and eight zirconium dioxide posts were cemented conventionally with glass ionomer cement; Panavia F resin cement was used for all others. The specimens were restored with direct composite restorations. Eight sound premolars served as the controls. After thermomechanical fatigue testing, the samples were loaded until fracture occurred at an angle of 45°. All specimens were evaluated for fracture lines. Results The sound teeth showed the significant highest fracture load (792.50 ± 210.01 N). The group restored with quartz fiber posts differed not significantly from the control. In the groups with fiber posts and titanium screws significant higher fracture load values occurred as in the group with direct composite restorations without posts. The groups with fiber posts did not show a more favorable fracture mode than the other groups. Clinical significance The use of an intraradicular post in premolars with class II cavities can significantly increase the resistance towards extra-axial forces.
- Published
- 2008
22. In-Service Chromatic Dispersion and Pass-Band Shape Measurements for Light Path with Modulated ASE Source
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T. J. Xia, B. Ruchet, J. Motter, Hongxin Chen, C. Iliopoulos, Daniel L. Peterson, G. W. Schinn, Wang-Chien Lee, Glenn A. Wellbrock, and J. Cervenka
- Subjects
Physics ,Amplified spontaneous emission ,Optics ,Band-pass filter ,business.industry ,Broadband ,Dispersion (optics) ,Ripple ,business ,Optical filter ,Phase modulation ,Passband - Abstract
A tunable modulated broadband source and narrow-bandwidth filter are used to measure chromatic dispersion, group-delay ripple, and pass-band shape of DWDM-network light paths. This new method is simple and suitable for in-service measurements.
- Published
- 2010
23. Turbomachinery monitoring systems capture and analyze vibration data
- Author
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R.D. Hayashida, J. Motter, and K. McDole
- Subjects
Engineering ,business.industry ,Data management ,Real-time computing ,Application software ,computer.software_genre ,Expert system ,Computer Science Applications ,Electric power system ,Data acquisition ,Software ,Computational Theory and Mathematics ,Control system ,Embedded system ,Transient (computer programming) ,Electrical and Electronic Engineering ,business ,computer - Abstract
An integrated, computerized monitoring system that provides for the capture and analysis of vibration data is described. The heart of the system is the Transient Data Manager (TDM) Communications Processor (CP), a computer interface that captures data during machine startup or coastdown. In addition, steady-state data are captured during online machine operation. Data captured include current static values and dynamic waveforms. The system collects and stores static data every four seconds from each monitor in a rack. In addition, dynamic transducer waveform data are captured and stored from each applicable monitor approximately every 40 seconds. Any time an alert, danger, or transducer-not-OK status is detected, the information is stored in an alarm event list. A status change notification is sent to the computer, and the computer subsequently retrieves the list and notifies the user of the status change. The system consists of at least one CP, software, and a computer. Examples of its application are provided. The future use of expert systems for this application is discussed. >
- Published
- 1991
24. [The timing of amniotomy: its effect on mother and infant]
- Author
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W J, Motter and P A, Weiss
- Subjects
Adult ,Parity ,Time Factors ,Cesarean Section ,Pregnancy ,Apgar Score ,Infant, Newborn ,Humans ,Female ,Amnion ,Fetal Hypoxia ,Obstetric Labor Complications - Abstract
This study was undertaken to determine how amniotomy performed during different phases of delivery affects mother and child. 1504 out of 4770 birth recorded during one year at the University Department of Obstetrics and Gynaecology in Graz were analyzed. None of these was associated with the presence of risk factors at the onset of delivery nor when amniotomy was performed. Regardless of parity, the number of ensuing complications was clearly related to the time at which amniotomy was performed: the earlier the amnion was perforated, the higher the rate of complications, particularly with primiparae. The aim of activation of labour, thereby accelerating the process of delivery by early amniotomy, was not, however, achieved. Consequently, amniotomy should not be regarded as the method of choice for the programmed induction or the acceleration of delivery. Medication should be the first step taken towards getting delivery under way and amniotomy postponed until contractions are well established and the uterine os is at least 7 cm open in primiparae and at least 4 cm in multiparae.
- Published
- 1984
25. Biocatalytic Nucleobase Diversification of 4'-Thionucleosides and Application of Derived 5-Ethynyl-4'-thiouridine for RNA Synthesis Detection.
- Author
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Westarp S, Benckendorff CMM, Motter J, Röhrs V, Sanghvi YS, Neubauer P, Kurreck J, Kurreck A, and Miller GJ
- Subjects
- Humans, HeLa Cells, Biocatalysis, Molecular Structure, Thiouridine analogs & derivatives, Thiouridine chemistry, Thiouridine metabolism, Thionucleosides chemistry, Thionucleosides metabolism, Thionucleosides chemical synthesis, RNA metabolism, RNA chemistry
- Abstract
Nucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections and cancer. One branch of structural modification to deliver new nucleoside analogue classes explores replacement of canonical ribose oxygen with a sulfur atom. Whilst biological activity of such analogues has been shown in some cases, widespread exploration of this compound class is hitherto hampered by the lack of a straightforward and universal nucleobase diversification strategy. Herein, we present a synergistic platform enabling both biocatalytic nucleobase diversification from 4'-thiouridine in a one-pot process, and chemical functionalization to access new entities. This methodology delivers entry across pyrimidine and purine 4'-thionucleosides, paving a way for wider synthetic and biological exploration. We exemplify our approach by enzymatic synthesis of 5-iodo-4'-thiouridine on multi-milligram scale and from here switch to complete chemical synthesis of a novel nucleoside analogue probe, 5-ethynyl-4'-thiouridine. Finally, we demonstrate the utility of this probe to monitor RNA synthesis in proliferating HeLa cells, validating its capability as a new metabolic RNA labelling tool., (© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
26. Predictors of Improvement after Cognitive Training in Mild Cognitive Impairment: Insights from the Cognitive Training and Neuroplasticity in Mild Cognitive Impairment Trial.
- Author
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Qian M, Motter J, Deehan E, Graff J, Adhikari A, Doraiswamy PM, Goldberg TE, and Devanand DP
- Subjects
- Humans, Male, Female, Aged, Neuropsychological Tests statistics & numerical data, Neuronal Plasticity physiology, Cognitive Behavioral Therapy methods, Treatment Outcome, Prognosis, Cognitive Training, Cognitive Dysfunction therapy
- Abstract
Objective: Cognitive training may benefit older adults with mild cognitive impairment (MCI), but the prognostic factors are not well-established., Methods: This study analyzed data from a 78-week trial with 107 participants with MCI, comparing computerized cognitive training (CCT) and computerized crossword puzzle training (CPT). Outcomes were changes in cognitive and functional measures from baseline. Linear mixed-effect models were used to identify prognostic factors for each intervention., Results: Baseline neuropsychological composite z-score was positively associated with cognitive and functional improvements for both interventions in univariable models, retaining significance in the final multivariable model for functional outcome in CPT ( P < 0.001). Apolipoprotein E e4 carriers had worse cognitive ( P = 0.023) and functional ( P = 0.001) outcomes than noncarriers for CPT but not CCT. African Americans showed greater functional improvements than non-African Americans in both CPT ( P = 0.001) and CCT ( P = 0.010). Better baseline odor identification was correlated with cognitive improvements in CPT ( P = 0.006) and functional improvements in CCT ( P < 0.001)., Conclusion: Baseline cognitive test performance, African American background, and odor identification ability are potential prognostic factors for improved outcomes with cognitive interventions in older adults with MCI. Apolipoprotein E e4 is associated with poor outcomes. Replication of these findings may improve the selection of cognitive interventions for individuals with MCI., Competing Interests: M.Q. received research grants from the National Science Foundation and National Institutes of Health (NIH). D.P.D. has received research grants from the National Institutes on Aging and Alzheimer’s Association and has served as a consultant on scientific advisory boards to Acadia, Corium, GSK, TauRx, and a DSMB for BioXcel. P.M.D. has received research grants from the NIH, DARPA, DOD, ONR, Salix, Avanir, Avid, Cure Alzhaimer’s Fund, Karen L. Wrenn Trust, US Highbush Blueberry Council, and Steve Aoki Foundation, and advisory/board fees from Apollo, Clearview, Lumos, Prospira, Keel Digital, Otsuka, Compass, Sermo, Nutricia, UMethod, and Transposon. He is a co-inventor of patents for the diagnosis or treatment of Alzheimer’s disease and a patent for infection detection. Also, owns shares in UMethod, Alzheon, Transposon, and MarvelBiome, the products of which are not discussed here. The remaining authors have received grant support from the NIH and declare no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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27. Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology.
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Motter J, Benckendorff CMM, Westarp S, Sunde-Brown P, Neubauer P, Kurreck A, and Miller GJ
- Subjects
- Biological Products chemistry, Biological Products pharmacology, Biological Products chemical synthesis, Molecular Structure, Humans, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents pharmacology, Purine Nucleosides chemistry, Purine Nucleosides chemical synthesis, Purine Nucleosides pharmacology
- Abstract
Covering: 2019 to 2023Nucleoside analogues represent one of the most important classes of small molecule pharmaceuticals and their therapeutic development is successfully established within oncology and for the treatment of viral infections. However, there are currently no nucleoside analogues in clinical use for the management of bacterial infections. Despite this, a significant number of clinically recognised nucleoside analogues are known to possess some antibiotic activity, thereby establishing a potential source for new therapeutic discovery in this area. Furthermore, given the rise in antibiotic resistance, the discovery of new clinical candidates remains an urgent global priority and natural product-derived nucleoside analogues may also present a rich source of discovery space for new modalities. This Highlight, covering work published from 2019 to 2023, presents a current perspective surrounding the synthesis of natural purine nucleoside antibiotics. By amalgamating recent efforts from synthetic chemistry with advances in biosynthetic understanding and the use of recombinant enzymes, prospects towards different structural classes of purines are detailed.
- Published
- 2024
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28. Unprecedented Mushroom Polyketide Synthases Produce the Universal Anthraquinone Precursor.
- Author
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Löhr NA, Eisen F, Thiele W, Platz L, Motter J, Hüttel W, Gressler M, Müller M, and Hoffmeister D
- Subjects
- Anthraquinones chemistry, Polyketide Synthases metabolism, Agaricales metabolism, Polyketides metabolism
- Abstract
(Pre-)anthraquinones are widely distributed natural compounds and occur in plants, fungi, microorganisms, and animals, with atrochrysone (1) as the key biosynthetic precursor. Chemical analyses established mushrooms of the genus Cortinarius-the webcaps-as producers of atrochrysone-derived octaketide pigments. However, more recent genomic data did not provide any evidence for known atrochrysone carboxylic acid (4) synthases nor any other polyketide synthase (PKS) producing oligocyclic metabolites. Here, we describe an unprecedented class of non-reducing (NR-)PKS. In vitro assays with recombinant enzyme in combination with in vivo product formation in the heterologous host Aspergillus niger established CoPKS1 and CoPKS4 of C. odorifer as members of a new class of atrochrysone carboxylic acid synthases. CoPKS4 catalyzed both hepta- and octaketide synthesis and yielded 6-hydroxymusizin (6), along with 4. These first mushroom PKSs for oligocyclic products illustrate how the biosynthesis of bioactive natural metabolites evolved independently in various groups of life., (© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
- Published
- 2022
- Full Text
- View/download PDF
29. Center-level Variation in HLA-incompatible Living Donor Kidney Transplantation Outcomes.
- Author
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Jackson KR, Long J, Motter J, Bowring MG, Chen J, Waldram MM, Orandi BJ, Montgomery RA, Stegall MD, Jordan SC, Benedetti E, Dunn TB, Ratner LE, Kapur S, Pelletier RP, Roberts JP, Melcher ML, Singh P, Sudan DL, Posner MP, El-Amm JM, Shapiro R, Cooper M, Verbesey JE, Lipkowitz GS, Rees MA, Marsh CL, Sankari BR, Gerber DA, Wellen J, Bozorgzadeh A, Gaber AO, Heher E, Weng FL, Djamali A, Helderman JH, Concepcion BP, Brayman KL, Oberholzer J, Kozlowski T, Covarrubias K, Desai N, Massie AB, Segev DL, and Garonzik-Wang J
- Subjects
- Adult, Female, Graft Rejection blood, Graft Rejection immunology, Graft Rejection mortality, Humans, Immunosuppressive Agents adverse effects, Male, Middle Aged, Quality Indicators, Health Care, Registries, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, United States, Graft Rejection prevention & control, Graft Survival drug effects, HLA Antigens immunology, Healthcare Disparities, Histocompatibility, Immunosuppressive Agents therapeutic use, Isoantibodies blood, Kidney Transplantation adverse effects, Kidney Transplantation mortality, Living Donors, Practice Patterns, Physicians'
- Abstract
Background: Desensitization protocols for HLA-incompatible living donor kidney transplantation (ILDKT) vary across centers. The impact of these, as well as other practice variations, on ILDKT outcomes remains unknown., Methods: We sought to quantify center-level variation in mortality and graft loss following ILDKT using a 25-center cohort of 1358 ILDKT recipients with linkage to Scientific Registry of Transplant Recipients for accurate outcome ascertainment. We used multilevel Cox regression with shared frailty to determine the variation in post-ILDKT outcomes attributable to between-center differences and to identify any center-level characteristics associated with improved post-ILDKT outcomes., Results: After adjusting for patient-level characteristics, only 6 centers (24%) had lower mortality and 1 (4%) had higher mortality than average. Similarly, only 5 centers (20%) had higher graft loss and 2 had lower graft loss than average. Only 4.7% of the differences in mortality (P < 0.01) and 4.4% of the differences in graft loss (P < 0.01) were attributable to between-center variation. These translated to a median hazard ratio of 1.36 for mortality and 1.34 of graft loss for similar candidates at different centers. Post-ILDKT outcomes were not associated with the following center-level characteristics: ILDKT volume and transplanting a higher proportion of highly sensitized, prior transplant, preemptive, or minority candidates., Conclusions: Unlike most aspects of transplantation in which center-level variation and volume impact outcomes, we did not find substantial evidence for this in ILDKT. Our findings support the continued practice of ILDKT across these diverse centers., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
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30. Induction immunosuppression and the risk of incident malignancies among older and younger kidney transplant recipients: A prospective cohort study.
- Author
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Wang L, Motter J, Bae S, Ahn JB, Kanakry JA, Jackson J, Schnitzler MA, Hess G, Lentine KL, Stuart EA, Segev DL, and McAdams-DeMarco M
- Subjects
- Adult, Aged, Antilymphocyte Serum adverse effects, Female, Graft Rejection, Humans, Immunosuppression Therapy adverse effects, Immunosuppressive Agents adverse effects, Medicare, Prospective Studies, United States epidemiology, Kidney Transplantation adverse effects, Neoplasms epidemiology, Neoplasms etiology
- Abstract
Background: Older (≥65) KT recipients differ from their younger counterparts in their immune response to immunosuppression (IS) and may have a different risk of malignancy after receiving induction., Methods: We identified 66 700 adult KT recipients treated with anti-thymocyte globulin (ATG) (n = 40 443) or interleukin-2 receptor antagonist (IL-2RA) (n = 26 327) induction (1/1/1999-12/31/2014) using USRDS/Medicare data. We estimated the risk of first-diagnosed post-KT malignancy associated with induction (ATG vs. IL-2RA) using Cox proportional hazard models. We then tested whether these risks differed between older and younger recipients (Wald test for interaction). Models incorporated inverse probability of treatment weights to adjust for confounders., Results: The 3-year cumulative incidences of any diagnosed malignancy were 11.5%. ATG was associated with a higher malignancy risk (HR = 1.12, 95%CI:1.06-1.18). This association differed (p
interaction = 0.04) between younger (HR = 1.12, 95%CI:1.06-1.18) and older recipients (HR = 1.03, 95%CI:0.96-1.09). ATG was also associated with higher risk of skin (HR = 1.18, 95%CI:1.08-1.29), lung (HR = 1.24, 95%CI:1.05-1.47), and ovary malignancies (HR = 1.94, 95%CI:1.08-3.48). However, only the association of ATG with post-KT skin malignancy differed (pinteraction = 0.01) between younger (HR = 1.18; 95%CI:1.08-1.29) and older (HR = 1.01; 95%CI:0.93-1.09) recipients., Conclusions: Compared with IL-2RA induction, ATG was associated with elevated post-KT malignancy risk but only among younger recipients. Transplant centers may need to tailor induction IS for younger recipients to mitigate malignancy risk., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)- Published
- 2020
- Full Text
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31. Effects of COVID19 Pandemic on Pediatric Kidney Transplant in the United States.
- Author
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Charnaya O, Chiang TP, Wang R, Motter J, Boyarsky B, King E, Werbel W, Durand CM, Avery R, Segev D, Massie A, and Garonzik-Wang J
- Abstract
In March 2020, COVID-19 infections began to rise exponentially in the United States, placing substantial burden on the healthcare system. As a result, there was a rapid change in transplant practices and policies, with cessation of most procedures. Our goal was to understand changes to pediatric kidney transplantation (KT) at the national level during the COVID-19 epidemic. Using SRTR data, we examined changes in pediatric waitlist registration, waitlist removal or inactivation, and deceased donor and living donor (DDKT/LDKT) events during the start of the disease transmission in the United States compared to the same time the previous year. We saw an initial decrease in DDKT and LDKT by 47% and 82% compared to expected events and then a continual increase, with numbers reaching expected pre-pandemic levels by May 2020. In the early phase of the pandemic, waitlist inactivation and removals due to death or deteriorating condition rose above expected values by 152% and 189%, respectively. There was a statistically significant decrease in new waitlist additions (IRR
0.49 0.650.85 ) and LDKT (IRR0.17 0.380.84 )in states with high vs low COVID activity. Transplant recipients during the pandemic were more likely to have received a DDKT, but had similar cPRA, waitlist time and cause of ESRD as before the pandemic. The COVID-19 pandemic initially reduced access to kidney transplantation among pediatric patients in the United States, but has not had a sustained effect. - Published
- 2020
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32. Pediatric deceased donor kidney transplant outcomes under the Kidney Allocation System.
- Author
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Jackson KR, Zhou S, Ruck J, Massie AB, Holscher C, Kernodle A, Glorioso J, Motter J, Neu A, Desai N, Segev DL, and Garonzik-Wang J
- Subjects
- Adolescent, Adult, Child, Death, Delayed Graft Function etiology, Delayed Graft Function pathology, Female, Follow-Up Studies, Graft Rejection etiology, Graft Rejection pathology, Graft Survival, Humans, Kidney Transplantation adverse effects, Male, Prognosis, Risk Factors, Young Adult, Delayed Graft Function mortality, Graft Rejection mortality, Kidney Failure, Chronic surgery, Kidney Transplantation mortality, Resource Allocation statistics & numerical data, Tissue Donors supply & distribution, Tissue and Organ Procurement statistics & numerical data
- Abstract
The Kidney Allocation System (KAS) has resulted in fewer pediatric kidneys being allocated to pediatric deceased donor kidney transplant (pDDKT) recipients. This had prompted concerns that post-pDDKT outcomes may worsen. To study this, we used SRTR data to compare the outcomes of 953 pre-KAS pDDKT (age <18 years) recipients (December 4, 2012-December 3, 2014) with the outcomes of 934 post-KAS pDDKT recipients (December 4, 2014-December 3, 2016). We analyzed mortality and graft loss by using Cox regression, delayed graft function (DGF) by using logistic regression, and length of stay (LOS) by using negative binomial regression. Post-KAS recipients had longer pretransplant dialysis times (median 1.26 vs 1.07 years, P = .02) and were more often cPRA 100% (2.0% vs 0.1%, P = .001). Post-KAS recipients had less graft loss than pre-KAS recipients (hazard ratio [HR]:
0.35 0.540.83 , P = .005) but no statistically significant differences in mortality (HR:0.29 0.721.83 , P = .5), DGF (odds ratio:0.93 1.321.93 , P = .2), and LOS (LOS ratio:0.96 1.061.19 , P = .4). After adjusting for donor-recipient characteristics, there were no statistically significant post-KAS differences in mortality (adjusted HR:0.37 1.042.92 , P = .9), DGF (adjusted odds ratio:0.94 1.412.13 , P = .1), or LOS (adjusted LOS ratio:0.93 1.041.16 , P = .5). However, post-KAS pDDKT recipients still had less graft loss (adjusted HR:0.38 0.590.91 , P = .02). KAS has had a mixed effect on short-term posttransplant outcomes for pDDKT recipients, although our results are limited by only 2 years of posttransplant follow-up., (© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.)- Published
- 2019
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33. Prenatal Exposure to Famine and Risk for Development of Psychopathology in Adulthood: A Meta-Analysis.
- Author
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Dana K, Finik J, Koenig S, Motter J, Zhang W, Linaris M, Brumberg JC, and Nomura Y
- Abstract
Prenatal famine, resulting in intrauterine malnutrition, impacts offspring psychopathology later in adulthood. In addition, the specific impact of intrauterine malnutrition of different psychopathology differs by the timing of the exposure. Using a meta-analysis, the current study assessed the specific risk of developing affective, psychotic, and personality disorders. Studies were identified using PubMed and PsycINFO. Studies met the following criteria for inclusion in the analysis: availability in peer-reviewed English journals, use of human subjects, prenatal exposure to famine, and psychopathology in adulthood defined by diagnostic criteria as an outcome. Fixed effect relative risks (RRs) were calculated for affective, psychotic, and personality domains. Furthermore, timing of exposure was assessed as an effect modifier in our analysis, defined by the index trimester at the height of famine. Our meta-analysis found that adults exposed in utero during the 1
st trimester were at a significant increased risk of psychotic disorders (RR=1.46, 95% CI=1.08, 1.97, p=0.014), and personality disorders (RR=2.31, 95% CI=1.36, 3.92, p =0.002). Those exposed during the 2nd trimester were at a significant increased risk of affective disorders (RR=1.45, 95% CI=1.22, 1.72, p <0.0001), and psychotic disorders (RR=1.46, 95% CI=1.13, 1.89, p=0.004). Similarly, those exposed in the 3rd trimester were at a significant increased risk of affective disorders (RR=1.33, 95% CI=1.13, 1.57, p =0.0001), and psychotic disorders RR=1.47, 95% CI=1.10, 1.97, p=0.010). Our findings suggest that there is differential risk across the different domains of psychopathology by trimester of exposures. This meta-analysis underscores the need for further investigation into the mechanisms underlying prenatal maternal nutrition and offspring psychopathology where magnitude of elevated risk differs by the exposure timing during pregnancy.- Published
- 2019
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34. Immunosuppressed Patients with Crohn's Disease Are at Increased Risk of Postoperative Complications: Results from the ACS-NSQIP Database.
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Abou Khalil M, Abou-Khalil J, Motter J, Vasilevsky CA, Morin N, Ghitulescu G, and Boutros M
- Subjects
- Adrenal Cortex Hormones therapeutic use, Adult, Anastomotic Leak etiology, Cohort Studies, Crohn Disease drug therapy, Databases, Factual, Elective Surgical Procedures adverse effects, Female, Humans, Male, Middle Aged, Surgical Wound Infection etiology, United States epidemiology, Young Adult, Anastomotic Leak epidemiology, Colectomy adverse effects, Crohn Disease surgery, Immunocompromised Host, Immunosuppressive Agents therapeutic use, Surgical Wound Infection epidemiology
- Abstract
Background: The impact of immunosuppressants on postoperative complications following colon resections for Crohn's disease remains controversial. This study aimed to compare postoperative outcomes between immunosuppressed and immunocompetent patients with Crohn's disease undergoing elective colon resection., Methods: Analysis of 30-day outcomes using a cohort from the American College of Surgeons National Surgical Quality Improvement Program colectomy-specific database was performed. The database is populated by trained clinical reviewers who collect 30-day postoperative outcomes for patients treated at participating North-American institutions. Adult patients who underwent an elective colectomy between 2011 and 2015 were included. Immunosuppression for Crohn's disease was predefined as use of regular corticosteroids or immunosuppressants within 30 days of the operation. Patients who received chemotherapy within 90 days of surgery, and patients who had disseminated cancer, preoperative shock, or emergency surgery were excluded. Primary outcome was infectious complications., Results: Three thousand eight hundred sixty patients with Crohn's disease required elective colon resection and met the inclusion criteria. Of these, 2483 were immunosuppressed and 1377 were immunocompetent. On multivariate analysis, the odds of infectious complications [OR 1.25; 95% CI (1.033-1.523)], overall surgical site infection [1.40; (1.128-1.742)], organ space surgical site infection [1.47; (1.094-1.984)], and anastomotic leak [1.51; (1.018-2.250)] were significantly higher for immunosuppressed compared to immunocompetent patients with Crohn's disease., Conclusions: Patients with Crohn's disease who were on immunosuppressant medications within 30 days of elective colectomy had significantly increased rates of infectious complications, overall surgical site infection, organ space surgical site infection, and anastomotic leak compared to patients who were not on immunosuppressive agents.
- Published
- 2019
- Full Text
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35. Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.
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Jayaraman S, Lee L, Mata J, Droeser R, Kaneva P, Liberman S, Charlebois P, Stein B, Fried G, Feldman L, Schellenberg M, Inaba K, Cheng V, Bardes J, Lam L, Benjamin E, Matsushima K, Demetriades D, Schellenberg M, Inaba K, Cho J, Strumwasser A, Grabo D, Bir C, Eastman A, Demetriades D, Schellenberg M, Inaba K, Bardes J, Orozco N, Chen J, Park C, Kang T, Demetriades D, Jung J, Elfassy J, Grantcharov T, Jung J, Grantcharov T, Jung J, Grantcharov T, Taylor J, Stem M, Yu D, Chen S, Fang S, Gearhart S, Safar B, Efron J, Serrano P, Parpia S, McCarty D, Solis N, Valencia M, Jibrael S, Wei A, Gallinger S, Simunovic M, Hummadi A, Rabie M, Al Skaini M, Shamshad H, Shah S, Verhoeff K, Glen P, Taheri A, Min B, Tsang B, Fawcett V, Widder S, Yang M, Wanis K, Gilani O, Vogt K, Ott M, VanKoughnett J, Vinden C, Balvardi S, St Louis E, Yousef Y, Toobaie A, Guadagno E, Baird R, Poenaru D, Kleiman A, Mador B, Widder S, Serrano P, Moulton C, Lee E, Li C, Beyfuss K, Solomon H, Sela N, McAlister V, Ritter A, Gallinger S, Hallet J, Tsang M, Martel G, Jalink D, Husien M, Gu C, Levine M, Otiti S, Nginyangi J, Yeo C, Ring J, Holden M, Ungi T, Fichtinger G, Zevin B, Fang B, Dang J, Karmali S, Serrano P, Kim M, Zhang B, Duceppe E, Rieder S, Maeda A, Okrainec A, Jackson T, Kegel F, Lachance S, Landry T, Feldman L, Fried G, Mueller C, Lee L, Kegel F, Kegel F, Lachance S, Lee L, Joharifard S, Nyiemah E, Howe C, Dobboh C, Kortimai LG, Kabeto A, Beste J, Garraway N, Riviello R, Hameed S, Shinde S, Marcil G, Prasad S, Arminan J, Debru E, Church N, Gill R, Mitchell P, Delisle M, Chernos C, Park J, Hardy K, Vergis A, Guez M, Hong D, Guez M, Hong D, Koichopolos J, Hilsden R, Thompson D, Myslik F, Vandeline J, Leeper R, Doumouras A, Govind S, Hong D, Govind S, Valanci S, Alhassan N, Lee L, Feldman L, Fried G, Mueller C, Wong T, Nadkarni N, Chia S, Seow D, Carter D, Li C, Valencia M, Ruo L, Parpia S, Simunovic M, Levine O, Serrano P, Vogt K, Allen L, Murphy P, van Heest R, Saleh F, Widder S, Minor S, Engels P, Joos E, Wang C, Nenshi R, Meschino M, Laane C, Parry N, Hameed M, Lacoul A, Lee L, Chrystoja C, Ramjist J, Sutradhar R, Lix L, Simunovic M, Baxter N, Urbach D, Ahlin J, Patel S, Nanji S, Merchant S, Lajkosz K, Brogly S, Groome P, Sutherland J, Liu G, Crump T, Bair M, Karimuddin A, Sutherland J, Peterson A, Karimuddin A, Liu G, Crump T, Koichopolos J, Hawel J, Shlomovitz E, Habaz I, Elnahas A, Alkhamesi N, Schlachta C, Akhtar-Danesh G, Doumouras A, Hong D, Daodu T, Nguyen V, Dearden R, Datta I, Hampton L, Kirkpatrick A, McKee J, Regehr J, Brindley P, Martin D, LaPorta A, Park J, Vergis A, Gillman L, DeGirolamo K, Hameed M, D'Souza K, Hartford L, Gray D, Murphy P, Hilsden R, Clarke C, Vogt K, Wigen R, Allen L, Garcia-Ochoa C, Gray S, Maciver A, Parry N, Van Koughnett J, Leslie K, Zwiep T, Ahn S, Greenberg J, Balaa F, McIsaac D, Musselman R, Raiche I, Williams L, Moloo H, Nguyen M, Naidu D, Karanicolas P, Nadler A, Raskin R, Khokhotva V, Poirier R, Plourde C, Paré A, Marchand M, Leclair M, Deshaies J, Hebbard P, Ratnayake I, Decker K, MacIntosh E, Najarali Z, Valencia M, Zhang B, Alhusaini A, Solis N, Duceppe E, Parpia S, Ruo L, Simunovic M, Serrano P, Murphy P, Murphy P, McClure A, Dakouo M, Vogt K, Vinden C, Behman R, Nathens A, Hong NL, Pechlivanoglou P, Karanicolas P, Lung K, Leslie K, Parry N, Vogt K, Leeper R, Simone P, Leslie K, Schemitsch E, Laane C, Chen L, Rosenkrantz L, Schuurman N, Hameed M, Joos E, George R, Shavit E, Pawliwec A, Rana Z, Laane C, Joos E, Evans D, Dawe P, Brown R, Hameed M, Lefebvre G, Devenny K, Héroux D, Bowman C, Mimeault R, Calder L, Baker L, Winter R, Cahill C, Fergusson D, Williams L, Schroeder T, Kahnamoui K, Elkheir S, Farrokhyar F, Wainman B, Hershorn O, Lim S, Hardy K, Vergis A, Arora A, Wright F, Nadler A, Escallon J, Gotlib L, Allen M, Gawad N, Raîche I, Jeyakumar G, Li D, Aarts M, Meschino M, Giles A, Dumitra T, Alam R, Fiore J, Mata J, Fried G, Vassiliou M, Mueller C, Lee L, Feldman L, Al Busaidi O, Brobbey A, Stelfox T, Chowdhury T, Kortbeek J, Ball C, AlShahwan N, Fraser S, Gawad N, Tran A, Martel A, Baxter N, Allen M, Manhas N, Balaa F, Mannina D, Khokhotva V, Tran A, Gawad N, Martel A, Manhas N, Allen M, Balaa F, Behman R, Behman A, Haas B, Hong NL, Pechlivanoglou P, Karanicolas P, Gawad N, Fowler A, Mimeault R, Raiche I, Findlay-Shirras L, Decker K, Singh H, Biswanger N, Park J, Gosselin-Tardif A, Khalil MA, Gutierrez JM, Guigui A, Feldman L, Lee L, Mueller C, Ferri L, Roberts D, Stelfox T, Moore L, Holcomb J, Harvin J, Sadek J, Belanger P, Nadeau K, Mullen K, Aitkens D, Foss K, MacIsaac D, Williams L, Musselman R, Raiche I, Moloo H, Zhang S, Ring J, Methot M, Zevin B, Yu D, Hookey L, Patel S, Yates J, Perelman I, Saidenberg E, Khair S, Taylor J, Lampron J, Tinmouth A, Lim S, Hammond S, Park J, Hochman D, Lê M, Rabbani R, Abou-Setta A, Zarychanski R, Patel S, Yu D, Elsoh B, Goldacre B, Nash G, Trepanier M, Alhassan N, Wong-Chong N, Sabapathy C, Chaudhury P, Liberman S, Charlebois P, Stein B, Feldman L, Lee L, Bradley N, Dakin C, Holm N, Henderson W, Roche M, Sawka A, Tang E, Murphy P, Allen L, Huang B, Vogt K, Gimon T, Rochon R, Lipson M, Buie W, MacLean A, Lau E, Alkhamesi N, Schlachta C, Mocanu V, Dang J, Tavakoli I, Switzer N, Tian C, de Gara C, Birch D, Karmali S, Young P, Chiu C, Meneghetti A, Warnock G, Meloche M, Panton O, Istl A, Gan A, Colquhoun P, Habashi R, Stogryn S, Abou-Setta A, Metcalfe J, Hardy K, Clouston K, Vergis A, Zondervan N, McLaughlin K, Springer J, Doumouras A, Lee J, Amin N, Caddedu M, Eskicioglu C, Hong D, Cahill C, Fowler A, Warraich A, Moloo H, Musselman R, Raiche I, Williams L, Keren D, Kloos N, Gregg S, MacLean A, Mohamed R, Dixon E, Rochan R, Ball C, Taylor J, Stem M, Yu D, Chen S, Fang S, Gearhart S, Safar B, Efron J, Yu D, Stem M, Taylor J, Chen S, Fang S, Gearhart S, Safar B, Efron J, Domouras A, Springer J, Elkheir S, Eskicioglu C, Kelly S, Yang I, Forbes S, Wong-Chong N, Khalil MA, Garfinkle R, Bhatnagar S, Ghitulescu G, Vasilevsky C, Morin N, Boutros M, Garfinkle R, Wong-Chong N, Petrucci A, Sylla P, Wexner S, Bhatnagar S, Morin N, Boutros M, Garfinkle R, Sigler G, Morin N, Ghitulescu G, Bhatnagar S, Faria J, Gordon P, Vasilevsky C, Boutros M, Garfinkle R, Khalil MA, Bhatnagar S, Wong-Chong N, Azoulay L, Morin N, Vasilevsky C, Boutros M, Alhassan N, Wong-Chong N, Trepanier M, Chaudhury P, Liberman A, Charlebois P, Stein B, Lee L, Alhassan N, Yang M, Wong-Chong N, Liberman A, Charlebois P, Stein B, Fried G, Lee L, Khorasani S, de Buck van Overstraeten A, Kennedy E, Hong NL, Mata J, Fiore J, Pecorelli N, Mouldoveanu D, Gosselin-Tardiff A, Lee L, Liberman S, Stein B, Charlebois P, Feldman L, Chau J, Bhatnagar S, Khalil MA, Morin N, Vasilevsky C, Ghitulescu G, Faria J, Boutros M, Fournier FR, Bouchard P, Khalil MA, Bhatnagar S, Khalil JA, Vasilevsky C, Morin N, Ghitulescu G, Faria J, Boutros M, Khalil MA, Morin N, Vasilevsky C, Ghitulescu G, Motter J, Boutros M, Wong-Chong N, Mottl J, Hwang G, Kelly J, Nassif G, Albert M, Lee L, Monson J, Wong-Chong N, Lee L, Kelly J, Nassif G, Albert M, Monson J, McLeod J, Cha J, Raval M, Phang T, Brown C, Karimuddin A, Karimuddin A, Robertson R, Letarte F, Karimuddin A, Raval M, Phang T, Brown C, Antoun A, Sigler G, Garfinkle R, Morin N, Vasilevsky C, Pelsser V, Ghitulescu G, Boutros M, Hyun E, Clouston-Chambers K, Hochman D, Helewa R, Park J, Candy S, Mir Z, Hanna N, Zevin B, Patel S, Azin A, Hirpara D, Quereshy F, Jackson T, Okrainec A, O'Brien C, Chadi S, Punnen S, Raval M, Karimuddin A, Phang T, Brown C, Yoon H, Brown C, Karimuddin A, Raval M, Phang T, Xiong W, Stuart H, Andrews J, Selvam R, Wong S, Hopman W, MacDonald P, Patel S, Dossa F, Medeiros B, Keng C, Acuna S, Hamid J, Baxter N, Ghuman A, Kasteel N, Brown C, Karimuddin A, Raval M, Phang T, Dossa F, Baxter N, Buie D, McMullen T, Elwi A, MacLean T, Wang H, Coutinho F, Le Q, Shack L, Roy H, Kennedy R, Hanna N, Zevin B, Bunn J, Mir Z, Chung W, Elmi M, Wakeam E, Azin A, Presutti R, Keshavjee S, Cil T, McCready D, Cheung V, Schieman C, Bailey J, Nelson G, Batchelor T, Grondin S, Graham A, Safieddine N, Johnson S, Hanna W, Cheung V, Schieman C, Bailey J, Nelson G, Low D, Safieddine N, Grondin S, Seely A, Bedard E, Finley C, Nayak R, Brogly S, Lajkosz K, Lougheed D, Petsikas D, Kinio A, Resende VF, Anstee C, Seely A, Maziak D, Gilbert S, Shamji F, Sundaresan S, Villeneuve P, Ojah J, Ashrafi A, Najjar A, Yamani I, Sersar S, Batouk A, Parente D, Laliberte A, McInnis M, McDonald C, Hasnain Y, Yasufuku K, Safieddine N, Waddell T, Chopra N, Nicholson-Smith C, Malthaner R, Patel R, Doubova M, Robaidi H, Anstee C, Delic E, Fazekas A, Gilbert S, Maziak D, Shamji F, Sundaresan S, Villeneuve P, Seely A, Taylor J, Hanna W, Hughes K, Pinkney P, Lopez-Hernandez Y, Coret M, Schneider L, Agzarian J, Finley C, Tran A, Shargall Y, Mehta M, Pearce K, Hanna W, Schneider L, Farrokhyar F, Agzarian J, Finley C, Shargall Y, Gupta V, Coburn N, Kidane B, Hess K, Compton C, Ringash J, Darling G, Mahar A, Gupta V, Kidane B, Ringash J, Sutradhar R, Darling G, Coburn N, Thomas P, Vernon J, Shargall Y, Schieman C, Finley C, Agzarian J, Hanna W, Spicer J, Renaud S, Seitlinger J, Al Lawati Y, Guerrera F, Falcoz P, Massard G, Ferri L, Hylton D, Huang J, Turner S, French D, Wen C, Masters J, Kidane B, Spicer J, Taylor J, Finley C, Shargall Y, Fahim C, Farrokhyar F, Yasufuku K, Agzarian J, Hanna W, Spicer J, Renaud S, Seitlinger J, St-Pierre D, Garfinkle R, Al Lawati Y, Guerrera F, Ruffini E, Falcoz P, Massard G, Ferri L, Agzarian J, Inra M, Abdelsattar Z, Allen M, Cassivi S, Nichols F 3rd, Wigle D, Blackmon S, Shen K, Gowing S, Robaidi H, Anstee C, Seely A, Beigee FS, Sheikhy K, Dezfouli AA, Shargall Y, Lopez-Hernandez Y, Schnurr T, Schneider L, Linkins L, Crowther M, Agzarian J, Hanna W, Finley C, Waddell T, de Perrot M, Uddin S, Douketis J, Taylor J, Finley C, Shargall Y, Agzarian J, Hanna W, Martel A, Angka L, Jeong A, Sadiq M, Kilgour M, de Souza CT, Baker L, Kennedy M, Auer R, Hallet J, Adam R, Karanicolas P, Memeo R, Goéré D, Piardi T, Lermite E, Turrini O, Lemke M, Li J, Dixon E, Tun-Abraham M, Hernandez-Alejandro R, Bennett S, Martel G, Navarro F, Sa Cunha A, Pessaux P, Hallet J, Isenberg-Grzeda E, Kazdan J, Beyfuss K, Myrehaug S, Singh S, Chan D, Law C, Nessim C, Paull G, Ibrahim A, Sabri E, Rodriguez-Qizilbash S, Berger-Richardson D, Younan R, Hétu J, Wright F, Johnson-Obaseki S, Angarita F, Elmi M, Zhang Y, Hong NL, Govindarajan A, Taylor E, Bayat Z, Bischof D, McCart A, Elmi M, Wakeam E, Azin A, Presutti R, Keshavjee S, McCready D, Cil T, Elmi M, Sequeira S, Azin A, Elnahas A, McCready D, Cil T, Samman S, Cornacchi S, Foster G, Thabane L, Thomson S, Lovrics O, Martin S, Lovrics P, Latchana N, Davis L, Coburn N, Mahar A, Liu Y, Hammad A, Kagedan D, Earle C, Hallet J, Zhang Y, Elmi M, Angarita F, Hong NL, Pang G, Hong NL, Paull G, Kupper S, Kagedan D, Nessim C, Quan M, Wright F, Hsiao R, Bongers P, Lustgarten M, Goldstein D, Dhar P, Rotstein L, Pasternak J, Nostedt J, Gibson-Brokop L, McCall M, Schiller D, Park J, Ratnayake I, Hebbard P, Mukhi S, Mack L, Singh N, Chanco M, Hilchie-Pye A, Kenyon C, Mathieson A, Burke J, Nason R, Kupper S, Austin J, Brar M, Wright F, Quan M, Hurton S, Quan M, Kong S, Xu Y, Thibedeau M, Cheung W, Dort J, Karim S, Crump T, Bouchard-Fortier A, Jeong Y, Mahar A, Li Q, Bubis L, Gupta V, Coburn N, Hirpara D, O'Rourke C, Azin A, Quereshy F, Chadi S, Dharampal N, Smith K, Harvey A, Pashcke R, Rudmik L, Chandarana S, Buac S, Latosinsky S, Shahvary N, Gervais M, Leblanc G, Brackstone M, Guidolin K, Yaremko B, Gaede S, Lynn K, Kornecki A, Muscedere G, Shmuilovich O, BenNachum I, Mouawad M, Gelman N, Lock M, Jayaraman S, Jayaraman S, Daza J, Solis N, Parpia S, Gallinger S, Moulton C, Levine M, Serrano P, Horkoff M, Sutherland F, Dixon E, Ball C, Bathe O, Moser M, Shaw J, Beck G, Luo Y, Ahmed S, Wall C, Domes T, Jana K, Waugh E, Tsang M, Jayaraman S, Tang E, Baird J, Newell P, Hansen P, Gough M, Garcia-Ochoa C, McArthur E, Tun-Abraham M, Hawel J, Skaro A, Leslie K, Garcia-Ochoa C, McArthur E, Tun-Abraham M, Leslie K, Skaro A, Gauvin G, Goel N, Mutabdzic D, Lambreton F, Kilcoyne M, Nadler A, Ang K, Karachristos A, Cooper H, Hoffman J, Reddy S, Park L, Gilbert R, Shorr R, Workneh A, Bertens K, Abou-Khalil J, Balaa F, Martel G, Smith H, Bertens K, Levy J, Hammad A, Davis L, Gupta V, Jeong Y, Mahar A, Coburn N, Hallet J, Mahar A, Jayaraman S, Serrano P, Martel G, Beyfuss K, Coburn N, Piardi T, Pessaux P, Hallet J, Ellis J, Bakanisi B, Sadeghi M, Beyfuss K, Michaelson S, Karanicolas P, Law C, Nathens A, Coburn N, Giles A, Daza J, Doumouras A, Serrano P, Tandan V, Ruo L, Marcaccio M, Dath D, Connell M, Selvam R, Patel S, Kleiman A, Bennett A, Wasey N, Sorial R, Macdonald S, Johnson D, Klassen D, Leung C, Vergis A, Botkin C, Azin A, Hirpara D, Jackson T, Okrainec A, Elnahas A, Chadi S, Quereshy F, Bahasadri M, Saleh F, Bahasadri M, Saleh F, Saleh F, Bahasadri M, MacLellan S, Tan J, Jun H, Cheah H, Wong K, Harvey N, Smith A, Cassie S, Sun S, Vallis J, Twells L, Lester K, Gregory D, Vallis J, Lester K, Gregory D, Twells L, Dang J, Sun W, Switzer N, Raghavji F, Birch D, Karmali S, Dang J, Switzer N, Delisle M, Laffin M, Gill R, Birch D, Karmali S, Marcil G, Bourget-Murray J, Switzer N, Shinde S, Debru E, Church N, Reso A, Mitchell P, Gill R, Sun W, Dang J, Switzer N, Tian C, de Gara C, Birch D, Karmali S, Jarrar A, Eipe N, Budiansky A, Walsh C, Mamazza J, Rashid M, and Engels P
- Published
- 2018
- Full Text
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36. [Analysis of water fluoride concentration in Curitiba, Brazil: comparison of techniques].
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Motter J, Moyses ST, França BH, de Carvalho ML, and Moysés SJ
- Subjects
- Brazil, Chlorine analysis, Fluoridation standards, Reproducibility of Results, Water Purification methods, Water Purification standards, Water Supply standards, Colorimetry methods, Fluorides analysis, Potentiometry methods, Water Supply analysis
- Abstract
Objective: To evaluate the adequacy of fluoride levels in the public water system in Curitiba, state of Paraná, Brazil, as determined by two techniques (colorimetric and electrometric)., Methods: Data from independent measurements of fluoride in the public water system in Curitiba routinely performed by the city government were obtained for the period between January 2000 and July 2008. Mean levels of fluoride concentration were calculated for each of these years. After that, fluoride concentrations measured in 1 470 samples by the state water utility (SANEPAR) using the electrometric technique in 2006 and 2007 were compared with the corresponding levels measured by the city using the colorimetric method. The rate of samples meeting the standard for the city (0.8 ppmF), and below and above the standard, was calculated for both methods. Fluoride levels were compared between sanitary districts, months for the period between December 2007 and July 2008, and water treatment facilities., Results: The overall mean fluoride level between 2000 and 2008 was 0.7 ppmF based on the independent measurements. The comparison between techniques showed a higher mean fluoride level with the electrometric technique (0.743 ppmF ± 0.133) vs. the colorimetric technique (0.637 ppmF ± 0.164). The rate of samples meeting the ideal standard of 0.8 ppmF was 15.05% for the colorimetric and 63.97% for the electrometric technique; 62.03% and 22.85% of the samples were below that standard and 21.10% and 13.18% were above that standard, respectively. Fluoride levels were statistically significant (P < 0.001) for the comparison between sanitary districts and months., Conclusions: The choice of technique significantly influences the resulting levels of fluoride. Independent monitoring of fluoride levels should employ the same technique used by the water utility. Further studies should aim at defining which technique is the most adequate to determine fluoride concentration in public water systems.
- Published
- 2011
- Full Text
- View/download PDF
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