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Marente is a village at the foot of the ancient Sumbawa volcano, located on the Tiu Kele river and the Agal waterfall, which empties directly into the sea. The ecological condition of the Tiu Kele river is an ideal environment for Stiphodon fish to live and breed. Therefore, this study focused on identifying the species of Stiphodon sp. (Gobiidae), whose presence has not been recorded in West Nusa Tenggara. There is still no literature study related to the Gobiidae family, especially the genus Stiphodon in the waters of the Tiu Kele river, which makes this research very important to do. This research was conducted from September 13 to October 13, 2021, in Tiu Kele river, Marente village, Sumbawa. The tools used are net, dipper, aquarium, sampling tubes, thermometer, pH meter, and camera, while the material used is 96% alcohol for specimen preparation. The identification results stated that Stiphodon atropurpureus had clearly visible characteristics. It had a bright blue body from the snout and cheeks to the tail, the dorsal fin is separated and fibrous. These results were also later strengthened from various related references about the physical properties and characteristics of Stiphodon atropurpureus. The results of this research can later be used as a reference and new data related to the distribution of stiphodon in Indonesia, especially in Lesser Sunda.

Perkembangan teknologi IOT saat ini begitu cepat seperti halnya modul Arduino yang memberikan kemudahan dalam implementasi di kehidupan sehari-hari. Dengan keterbatasan jumlah guru dalam mengawasi prilaku anak ketika berada dilingkungan sekolah, menajadi permasalahan yang terus menerus. Maka perlu kiranya dikembangkan suatu inovasi baru dalam bentuk suara otomatis dilingkungan sekolah. Dengan penelitian yang berjudul “Inovasi Rancang Bangun Suara Otomatis Menggunakan Arduino Di SMK Negeri 3 Sumbawa Besar ini sekira akan membantu guru dalam memantau tindakkan indisipler siswa yang sering terjadi hampir setiap hari. Pada penelitian ini menggunakan metode kuantitatif eksperimen, dimana pada rancangan ini terdiri dari 4 komponen utama yaitu berupa sensor PIR, Arduino, DFplayer dan Speaker. Sinyal inputan yang berasal dari sensor PIR karena adaynaya gerakan anak disekitar sensor diteruskan ke Arduino untuk di proses selanjutnya sinyal akan diteruskan ke Speaker melalui DFplayer. Dari hasil pngujian sensor PIR membaca gerakkan anak kemudian dari hasil pembacaan dikirim ke Arduino melalui pin D1 memalalui software Arduino data diinisialisasi untuk diolah kemudian dikirim ke DFplayer yang selanjutkan output suara melalui speaker. Pengujian sistem secara keseluruhan berjalan dengan baik pada pembacaan sensor jarak maximal 4 m dari gerakkan.

Department of the environment around 10.660 hectares of mangroves with varuous types. One that has the potential for mangrove development is Dusun Prajak, located in the Saleh bay area which is directly adjacent to the Moyo Tambora biosphere zone that has a major influence on the preservation of marine natural resources such as coral and whale sharks. The purpose is to provide skill in making natural dyes made from mangroves to community. The method is observation, interviews, practice and assistance with the Participatory Rural Appraisal (PRA) approach. Furtermore, mentoring and evaluation are carried out. The survey result show that weaving based on natural dyes from mangroves has never been done, so it is important to carry out demonstrations of making mangrove dyes. The training program received high appreciation from the community because it was uniqe and hope that program would continue and community would be assisted. Abstrak Berdasarkan data Dinas Lingkungan Hidup, sekitar 10.660 hektar mangrove dengan jenis yang beragam. Salah satu yang memiliki potensi pengembangan mangrove adalah Dusun Prajak, terletak di wilayah Teluk Saleh yang langsung berbatasan dengan zona biosfer Moyo-Tambora sehingga dusun prajak berpengaruh besar dalam kelestarian SDA laut seperti karang dan seperti Hiu Paus. Tujuan pengabdian yaitu memberikan skill pembuatan pewarna tenun alami berbahan mangrove kepada masyarakat. Metode yang digunakan adalah metode observasi, wawancara, praktik dan pendampingan dengan pendekatan Participatory Rural Appraisal. Selanjutnya dilakukan pendampingan dan evaluasi. Hasil survei menunjukkan bahwa tenun berbasis bahan pewarna alami dari mangrove belum pernah dilakukan, sehingga penting dilaksanakan demonstrasi pembuatan pewarna mangrove. Program pengabdian ini mendapat apresiasi tinggi dan berharap program ini terus dilanjutkan dan masyarakat didampingi.

The increasing demand for Muslim-friendly products and services has led hoteliers in Malaysia to provide more Muslim-friendly hotel (MFHs) services to fulfill Muslim tourists' needs. However, previous studies have shown that there is still a lack of conformity between MFHs and their guests, which harms MFHs' service performance. It is essential to expand the discussion on improving service performance in MFHs. The data of 390 MFH employees in Kuala Lumpur and Selangor had been gathered quantitatively, and the data were analyzed using structural equation modeling and partial least squares analysis. Keywords: Internal Measurement of Service Quality (INTQUAL); Employees’ Relation; Service Performance; Muslim Friendly Hotels. eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under the responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i21.3679

Staatenoodrecht ialah hak darurat, dimana kegentingan kesehatan nasional sebagai ancama bagi masyarakat, maka dalam hal ini pemerintah tetap memaksakan Pemilihan Umum di tengah pandemi covid 19 yang melanda Indonesia dan ketegori darurat kesehatan nasional sudah tertuang di didalam kepres, Maka Pemilihan Umum yang dilaksanakan di tengah kondisi Negara dalam keadaan darurat harus di pertegas secara hukum yang berlaku, Jenis penetian ini Normatif, Adapun pendekatan yang digunakan adalah pendekatan perundang-undangan dan pendekatan konsep. Bahan hukum primer yang dianalisa adalah yang berhubungan keputusan presiden terhadap penetapan bencana dalam keadaan darurat, Bahan hukum sekunder di dapat dari literature terkait pelaksanaan pemilukada di tengah Negara dalam keadaan darurat.Hasil ini menunjukan bahwa ketika pilkada dilaksanakan di tengah keadaan darurat, maka kualitas hasil demokrasinya kurang baik, sejatinya jika keadaan neagara dalam darurat maka aktifitas yang membahayakan pada masyarakat harus di utamakan, dalam hal ini pemerintah masih belum konsisten terhadap penetapan covid 19 sebagai darurat kesehatan nasional, terbukti dengan terlaksananya pemilukada di tengah bencana non alam tersebut.Kata Kunci: Darurat Kesehatan, Pemilihan Umum, Covid-19

Rasborabaliensis(Hubbs & Brittan, 1954) is a native freshwater fish from Indonesia, which was described in East Java, Bali Island, and the West Lesser Sunda Islands. In the present paper, we reported on the presence of R. baliensis, which was collected from several new rivers in Java and East Lesser Sunda Islands. The specimen was identified as R. baliensisbased on the number of scales on the lateral line 26 and on the predorsal 12;the upper head and body are light brown while the lower jaw and belly are silver; mid-lateral stripe from opercle to caudal base light blue; dorsal, caudal, and anal fins yellowish; and pectoral and ventral fins hyaline. The paper also showed the current distribution range of this species. The new records of native freshwater fish are important contributions to understanding species diversity and biogeography.

An individual of Longnose marbled whipray Fluvitrygon oxyrhyncha (Sauvage, 1878) (60 cm of total length) was caught and photographed on 3 August 2020, from Pahang River, Kuala Lipis District, Pahang, Malaysia. This rare finding represents the first-ever known record of F. oxyrhyncha in Malaysian waters, and only the fourth record in Southeast Asia besides former records of F. oxyrhyncha from Thailand, Cambodia, and Indonesia. Further study and monitoring is needed to asses the possibility of the importance of Pahang River as habitat of F. oxyrhyncha.

Insurance growth in Indonesia has recently experienced a pretty good increase, this is evidenced by the statistics of IKNB (Non-Bank Financial Industry) issued by the OJK (Financial Services Authority) in February 2020. In December 2018 the number of IKNB actors was 1260 and then increased every month until December 2019 IKNB actors totaled 1330. From these data IKNB actors experienced a pretty good increase, where insurance is included in the industry. With so many IKNB actors PT. SICO Andalan Utama, which is one of the companies engaged in the industry, is feeling the improvement. However, with this increase, insurance management, specifically claims management, is needed because caution is needed when deciding on a claim worthiness decision. So to overcome these problems this is what underlies the authors to propose the development of a Decision Support System for Insurance Claim Feasibility which will later be expected to avoid or at least reduce inaccuracies in determining the eligibility of a claim. This Decision System for Claims Feasibility Decision Support System was developed using the Rapid Application Development (RAD) system development methodology as a path for developing the system. Whereas the DSS modeling uses the Analytical Hierarchy Process (AHP) model. And also uses several Unified Modeling Language (UML), Business Process Modeling Nation (BPMN), and Entity Relationship Diagram (ERD) tools for analysis and design. In implementing the system the author uses PHP as a programming language and MySQL as a Database. The testing method uses White Box Testing, Black Box Testing and Usability Testing approaches. By implementing this system, it is expected to provide the right claim eligibility decisions.

Coral reef is a critical underwater ecosystem that is rich in biodiversity. Coral growth has decreased drastically due to physical and chemical threats, such as the effect of warming seawater, fish bombing activities, and the effects of wastewater. The efficiency level of coral transplantation is determined by many factors, including the stability of the environment physical condition, the level of coral diversity, and the method of transplantation. The influence of the planting medium can also be a key factor in succeeding the coral transplantation process. The use of stable and natural growing media can be a solution to replace conventional growing media that have been used. Zeolite material is a medium that has many advantages such as amending the trace elemental contents of saltwater such as carbon absorbents, detoxifiers, ammonia remover, catalysts, promoting marine micro-algal growth, become a media for bacterial growth, etc. This review discusses the possibility of zeolites as the candidate media that can be used as a new medium in coral transplantation process to accelerate coral growth and maintain coral health by increasing the adaptation of corals to the effects of global climate change.

A single specimen (c. 86.2 cm) juvenile of Bull shark Carcharhinus leucas (Müller & Henle, 1839) was captured and photographed by local fisherman using a casting net on 13 February 2018 in Pangkajene River, about 16 km inland, Pangkajene District, South Celebes, Indonesia. This finding is considered as a first inland record of C. leucas in Celebes, and fourth inland records in Indonesia after Papua, Sumatra and Borneo. Monitoring is needed to asses the possibility of Celebes as a migration route and breeding ground of C. leucas.

Trigona spp . atau stingless bee merupakan jenis lebah yang banyak ditemukan di daerah tropis. Madu dan propolis yang dihasilkan oleh jenis lebah ini mengandung bakteri asam laktat (BAL) yang dapat dijadikan sebagai kandidat probiotik. Berdasarkan hal tersebut maka BAL tersebut juga diduga dapat ditemukan pada sarangnya. Tujuan penelitian ini adalah untuk melakukan isolasi dan karakterisasi BAL dari sarang lebah Trigona spp ., serta melakukan pengujian aktivitas antibakteri terhadap bakteri uji Salmonella thypi dan Staphylococcus aureus . Bakteri asam laktat diisolasi dari sarang lebah Trigona spp . pada media MRSA. Seleksi BAL dilakukan dengan uji pewarnaan Gram dan uji katalase. Delapan isolat BAL telah berhasil diisolasi dari sarang lebah Trigona spp .. Kedelapan isolat tersebut kemudian dikulturkan dan dilakukan ekstraksi metabolit sekunder. Hasil ekstraksi diujikan pada bakteri S. thypi dan S. aureus menggunakan metode difusi sumur. Hasil yang diperoleh menunjukkan bahwa kedelapan isolat memiliki perbedaan efektivitas penghambatan bakteri uji. Isolat SRG 1 lebih efektif menghambat pertumbuhan bakteri S. thypi dengan ukuran zona bening terbesar 1,3± 0,471 mm. Sedangkan isolat SRG 19 efektif menghambat pertumbuhan bakteri S. aureus dengan ukuran zona bening terbesar 5,3 ± 0,471 mm.

Kelurahan Geres merupakan salah satu Kelurahan yang terletak di Kecamatan Labuhan Haji, Kabupaten Lombok Timur, Nusa Tenggara Barat. Mata pencaharian dari masyarakat Kelurahan Geres berkaitan dengan pengelolaan tambang batu apung, dan pasir, selain hal ini terdapat juga bisnis kuliner yang khas dari Kelurahan ini, yaitu keripik singkong yang dinamakan JEGER ( Jeje Geres ). Jeger merupakan keripik yang terbuat dari singkong asli. Mengenai bisnis ini masih terdapat banyak kekurangan dari segi pemasaran dan juga kesiapan Kelompok pengelola dalam meningkatkan pemasaran dan inovasi dari produk ini sehingga KKN Kelurahan Geres 2021 dengan tema pengenalan Digital marketing dan inovasi produk guna mendukung pemasaran serta meningkatkan kualitas produk dari kelompok JBL (Jeger Buana Lombok). Tujuan pertama dalam kegiatan KKN ini adalah memberikan pelatihan yang berkaitan dengan pemasaran di bidang online atau yang lebih dikenal dengan kegiatan Digital Marketing yang diharpakan dapat mendongrak sistem pemasaran dari kelompok ini. Selain pengenalan secara luas terkait dengan Digital Marketing cangkupan cangkupan pelatihan di dalam Digital Marketing ini juga berkaitan dengan pengenalan aplikasi yang digunakan di dalam pemasaran online, selain itu juga diberikan pelatihan fotografi, videografi, serta desain grafis. Tujuan yang kedua berkaitan dengan perbaikan nilai ekonomi melalui perbaikan logo, kemasan dan juga inovasi beberapa varian rasa dari usaha Jeger.

This research was conducted with the aim to determine the effect of storage time and concentration ofsolution of betel leaf as a natural disinfectant in quail hatching eggs. This study used a factorialCompletely Randomized Design (CRD) with 2 factors, namely factor A consisted of ole (storage time 5and 7 days), factor B consisted of (dyeing betel leaf solution with treatment P0 = Without treatment, P1 =100 grams of betel leaf + 500 ml of water, P2 = 100 grams of betel leaf + 1000 ml of water, and P3 = 100 grams of betel leaf + 1500 ml of water). The material used in this study was 320 eggs of quail and 2 unitsof hatchery with a capacity of 200 eggs. The results of this study indicate that the interaction of treatmentbetween factor A and factor B, as well as the treatment of each individual, did not have an effect on thesurvival of the embryo, hatchability and the hatch weight of quail eggs.Keywords: Embryo, hatchability, hatch weight,betel leaf, quail.

Hasan V, Valen FS, Islamy RA, Widodo MS, Saptadjaja AM, Islam I. 2021. Short Communication: Presence of the vulnerable freshwater goby Sicyopus auxilimentus (Gobiidae, Sicydiinae) on Sangihe Island, Indonesia. Biodiversitas 22: 571-579. A single specimen of freshwater goby Sicyopus auxilimentus was photographed and collected using fish traps between 8 and 15 September 2019 in the Laine waterfall, Sangihe island district, North Sulawesi Province, Indonesia. S. auxilimentus is amphidromous that live in both freshwater and marine environments. This species is currently listed as Vulnerable (VU) within the IUCN Red List Status. The specimen was identified as male S. auxilimentus based on the coloration of the preserved specimen: background yellowish; scale edges brown; posterior flanks and caudal peduncle orange; first dorsal fin black, second dorsal fin dusky black; pectoral fin slightly brown; ventral fin slightly dusky; anal fin blackish; caudal fin dusky brown. Specific morphological features were as follows: the base of the first dorsal fin was not connected to the second dorsal fin base; distance between the base of first and second dorsal fin was generally less than half of eye diameter; ventral fin rays were fused to belly only between fifth rays; posterior margin of caudal fins rays was rounded; scales were all ctenoid; scales appeared on the caudal peduncle, and between anal and second dorsal fins; anterior to which, scales became widely spaced and did not imbricate. Meristic characters were as follows: first dorsal fin rays VI; second dorsal fin rays I+9; ventral fin rays I+5; pectoral-fin rays 14; anal-fin rays I+9; caudal-fin rays 13; scales in lateral series 13; scales in zigzag series 7; scales in transverse series backward 7; scales in transerves series forward 4. This finding is considered the first record in Sulawesi and the fifth from Indonesian waters after findings in Halmahera, Java, Bali and Lombok. This record enhances the understanding of the distribution of S. auxilimentus in Indonesian waters. Monitoring is needed to assess the possibility of Sangihe Island being a growth ground, spawning ground, and/or on the migration route of S. auxilimentus. In the Laine waterfall, Sangihe island, freshwater conditions were as follows: salinity 3.5 psu, temperature 23-25°C, and dissolved oxygen 7.7-9.2 mg/l, which were ideal habitat for S. auxilimentus. S. auxilimentus from Sangihe Island, had 0.000 genetic distance than from S. auxilimentus from Bali, while the next closest genetic distance was S. zosterophorus at genetic distance of 0.090. In addition to onsite conservation, domestication programs are needed to increase commercial availability without depending on natural catches.

Hasan V, Valen FS, Islamy RA, Widodo MS, Saptadjaja AM, Islam I. 2021. Short Communication: Presence of the vulnerable freshwater goby Sicyopus auxilimentus (Gobiidae, Sicydiinae) on Sangihe Island, Indonesia. Biodiversitas 22: 571-579. A single specimen of freshwater goby Sicyopus auxilimentus was photographed and collected using fish traps between 8 and 15 September 2019 in the Laine waterfall, Sangihe island district, North Sulawesi Province, Indonesia. S. auxilimentus is amphidromous that live in both freshwater and marine environments. This species is currently listed as Vulnerable (VU) within the IUCN Red List Status. The specimen was identified as male S. auxilimentus based on the coloration of the preserved specimen: background yellowish; scale edges brown; posterior flanks and caudal peduncle orange; first dorsal fin black, second dorsal fin dusky black; pectoral fin slightly brown; ventral fin slightly dusky; anal fin blackish; caudal fin dusky brown. Specific morphological features were as follows: the base of the first dorsal fin was not connected to the second dorsal fin base; distance between the base of first and second dorsal fin was generally less than half of eye diameter; ventral fin rays were fused to belly only between fifth rays; posterior margin of caudal fins rays was rounded; scales were all ctenoid; scales appeared on the caudal peduncle, and between anal and second dorsal fins; anterior to which, scales became widely spaced and did not imbricate. Meristic characters were as follows: first dorsal fin rays VI; second dorsal fin rays I+9; ventral fin rays I+5; pectoral-fin rays 14; anal-fin rays I+9; caudal-fin rays 13; scales in lateral series 13; scales in zigzag series 7; scales in transverse series backward 7; scales in transerves series forward 4. This finding is considered the first record in Sulawesi and the fifth from Indonesian waters after findings in Halmahera, Java, Bali and Lombok. This record enhances the understanding of the distribution of S. auxilimentus in Indonesian waters. Monitoring is needed to assess the possibility of Sangihe Island being a growth ground, spawning ground, and/or on the migration route of S. auxilimentus. In the Laine waterfall, Sangihe island, freshwater conditions were as follows: salinity 3.5 psu, temperature 23-25°C, and dissolved oxygen 7.7-9.2 mg/l, which were ideal habitat for S. auxilimentus. S. auxilimentus from Sangihe Island, had 0.000 genetic distance than from S. auxilimentus from Bali, while the next closest genetic distance was S. zosterophorus at genetic distance of 0.090. In addition to onsite conservation, domestication programs are needed to increase commercial availability without depending on natural catches.

Coral reef is an important underwater ecosystem that is rich in biodiversity in it. Coral growth has decreased drastically due to physical and chemical threats, such as the effect of warming seawater, fish bombing activities, and the effects of wastewater. The efficiency level of coral transplantation is determined by many factors, including the stability of the environment's physical condition, the level of coral diversity, and the method of transplantation. The influence of the planting medium can also be a key factor in succeeding the coral transplantation process. The use of stable and natural growing media can be a solution to replace conventional growing media that have been used. Zeolite material is a medium that has many advantages such as amending the trace elemental contents of saltwater such as carbon absorbents, detoxifiers, ammonia remover, catalysts, promoting marine micro-algal growth, become a media for bacterial growth, etc. This review discusses the possibility of zeolites as the candidate media that can be used as a new medium in coral transplantation process to accelerate coral growth and maintain coral health by increasing the adaptation of corals to the effects of global climate change.

An enhancer located upstream of the transcriptional start site of

An enhancer located upstream of the transcriptional start site of Ccnb1ip1 containing two GGA-rich regions and a 14-GGA repeat (GGA)14 region has been previously identified. Three copies of four GGA repeats in the c-myb promoter that form a tetrad:heptad:heptad:tetrad (T:H:H:T) dimerized G-quadruplex (G4) structure reportedly functions as both a transcriptional repressor and activator. Here, the secondary structures of the two GGA-rich and (GGA)14 regions were analyzed using circular dichroism spectral analysis, which indicated that the two GGA-rich DNAs formed parallel-type G4 structures, whereas (GGA)14 DNA formed the T:H:H:T dimerized G4 structure. Reporter assays demonstrated that individual regions did not show enhancer activity; however, the deletion of the (GGA)14 region resulted in 1.5-fold higher enhancer activity than that of the whole enhancer. These results indicate that the (GGA)14 region that forms the T:H:H:T dimerized G4 structure functions as a negative regulator of the Ccnb1ip1 enhancer. The (GGA)14 region that forms a dimerized G-quadruplex structure functions as a negative regulator of the Ccnb1ip1 enhancer.

Penelitian ini mendiskusikan tentang penggunaan response tokens dalam Waiting for Godot oleh Samuel Beckett. Ada dua karakter utama yang diteliti dalam penelitian ini, yakni Vladimir dan Estragon. Penulis mencoba untuk menjawab dua pertanyaan, yakni (1) apa saja jenis response tokens yang dituturkan oleh karakter-karakter utama dalam Waiting for Godot oleh Samuel Beckett dan (2) apa saja fungsi response tokens tersebut dalam Waiting for Godot oleh Samuel Beckett. Penulis menggunakan pendekatan kualitatif deskriptif karena data yang dikumpulkan tidak berupa angka. Selain itu, dia menggunakan pendekatan tersebut untuk memperoleh deskripsi dan pemahaman yang kaya tentang response tokens dalam Waiting for Godot. Data diambil hanya dari tuturan Vladimir and Estragon dikarenakan mereka selalu muncul sepanjang drama dan mereka mengucapkan response tokens paling banyak. Penelitian ini menghasilkan fakta bahwa response token dalam Waiting for Godot ini masuk dalam semua tipe response token yang dikemukakan oleh McCarthy (2003). Tipe-tipe response token yang ada dalam drama tersebut yaitu single response token, response token preceding expanded response, premodified response token, negated token and doublet and triplet token. Penulis menjelaskan lebih jauh tentang fungsi response tokens tersebut termasuk fungsi continuers, acknowledgement, newsmarker, change-of-activity, assessement and brief question token. Penjelasan fungsi-fungsi tersebut juga mempertimbangkan konteks. Dari penelitian ini, penulis dapat menyimpulkan bahwa doublet and triplet token adalah jenis yang sering digunakan dalam Waiting for Godot, sedangkan fungsi acknowledgement muncul lebih banyak daripada fungsi-fungsi yang lain. Penelitian ini juga menemukan bahwa token "yes" diucapkan lebih banyak daripada token-token yang lain, yang fungsinya adalah untuk menyetujui dan memperkuat perkataan penutur utama. Seseorang seharusnya mengetahui fungsi dari response token dan menggunakannya dalam percakapan sehari-hari karena hal tersebut memberikan cara yang efektif untuk menunujukkan ekspresi afektif.

Cervical cancer is the second largest cause of death-related cancer in women. The efficacy of cancer drugs is still low. Bioactive of brown seaweed has been studied by in vitro and in vivo as anticancer. The aim of this study was to evaluate the cytotoxicity of Sargassum polycystum extracts on HeLa cell, to recognize bioactive on extract and estimate the interaction between the bioactive and target protein. S. polycystum was found from Talango Island waters and HeLa cell was obtained from Indonesian Science Institute. Sample was extracted by ethanol, ethyl acetate and hexane, concentrated and finally, extracts were assayed on HeLa cell. The viability of this cell was quantified on ELISA-Reader. The bioactive compounds of the extract were elucidated by GC-MS. The interaction between bioactive and target protein was evaluated by using in silico method. The result showed that the lowest viability of HeLa cell on n-hexane extracts treatment. The n-hexane extract of this seaweed contained benzenepropanoic acid. This compound reduced HeLa cell viability by reducing of thrombin concentration. In conclusion, the benzene propanoic acid of S. polycystum was the cytotoxic agent and it is potential agent for anti-cervical cancer.