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9 results on '"Izquierdo-Gómez, Keila"'

6. Factores asociados a la malignización del líquen plano oral. Revisión de la literatura

Author

Asensi Anta, E., Sardañés Martínez, S., Izquierdo-Gómez, Keila, Jané Salas, Enric, Estrugo Devesa, Albert, and López López, José, 1958

Subjects
Liquen plano oral, Systematic reviews (Medical research), Oral cancer, Liquen pla, Transformación maligna del liquen plano, Carcinoma de células escamosas, Cáncer oral, Ressenyes sistemàtiques (Investigació mèdica), Lichen planus, Càncer de boca
Abstract

RESUMEN Introcucción: El liquen plano (LP) es una enfermedad sistémica autoinmune de etiología desconocida y curso crónico que puede resultar en el desarrollo de carcinoma oral de células escamosas (COCE). Objetivo: Evaluar la evidencia relacionada con la malignización del LPO, así como las características clínicas y la incidencia de las lesiones que pueden desarrollan un COCE. Material y métodos: Se revisa la base de datos MEDLINE PubMed de los últimos 5 años (2013-2018) utilizando las siguientes palabras clave: “malignant transformation of oral lichen planus” and “squamous cell oral carcinoma”. Resultados: Se obtuvieron 48 artículos de los cuales tras la lectura resúmenes y la aplicación de nuestros criterios de inclusión y exclusión obtuvimos un total de 19 artículos, además de los 4 artículos añadidos mediante búsqueda manual. La revisión se basa en la comparación de 9 estudios de cohortes para analizar la incidencia de la progresión de LPO a COCE. Conclusiones: Debemos considerar el LPO como una enfermedad potencialmente maligna (0.5- 1%) siendo el sexo femenino, el tipo erosivo y la localización en la lengua factores de riesgo para la transformación a COCE. Teniendo en cuenta el riesgo de malignización es esencial el control de las lesiones para poder realizar un diagnóstico precoz.

Published
2019

7. The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis

Author

Universidad de Sevilla. Departamento de Estomatología, Roca-Millan, Elisabeth, González-Navarro, Beatríz, Izquierdo-Gómez, Keila, Marí-Roig, Antonio, Jané-Salas, Enric, López-López, José, Velasco-Ortega, Eugenio, Universidad de Sevilla. Departamento de Estomatología, Roca-Millan, Elisabeth, González-Navarro, Beatríz, Izquierdo-Gómez, Keila, Marí-Roig, Antonio, Jané-Salas, Enric, López-López, José, and Velasco-Ortega, Eugenio

Abstract

This systematic review aims to analyze the effect of the local application of statins in the regeneration of non-periodontal bone defects. A systematic study was conducted with the Pubmed/Medline, Embase, Cochrane Library and Scielo databases for in vivo animal studies published up to and including February 2019. Fifteen articles were included in the analysis. The local application of the drug increased the percentage of new bone formation, bone density, bone healing, bone morphogenetic protein 2, vascular endothelial growth factor, progenitor endothelial cells and osteocalcin. Meta-analyses showed a statistically significant increase in the percentage of new bone formation when animals were treated with local statins, in contrast to the no introduction of filling material or the introduction of polylactic acid, both in an early (4–6 weeks) and in a late period (12 weeks) (mean difference 39.5%, 95% confidence interval: 22.2–56.9, p <0.001; and mean difference 43.3%, 95% confidence interval: 33.6–52.9, p < 0.001, respectively). Basing on the animal model, the local application of statins promotes the healing of critical bone size defects due to its apparent osteogenic and angiogenic effects. However, given the few studies and their heterogenicity, the results should be taken cautiously, and further pilot studies are necessary, with radiological and histological evaluations to translate these results to humans and establish statins’ effect

Published
2019

9. Evaluation of the quality of life and satisfaction in patients using complete dentures versus mandibular overdentures. Systematic review and meta‐analysis.

Author

Egido Moreno, Sonia, Ayuso Montero, Raul, Schemel Suárez, Mayra, Roca‐Umbert, Joan Valls, Izquierdo Gómez, Keila, and López López, José

Subjects
QUALITY of life
Abstract

Background: The World Health Organization (WHO) recognizes edentulism as a physical impairment that results in a negative impact in the daily activities. Objective: The study aimed to compare the satisfaction and the quality of life, in patients treated with implant retained overdentures with two mandibular implants (IOD) against those with mandibular conventional complete dentures (CCD). Methods: Different search strategies were used to screen for articles in Pubmed/Medline, Cochrane Library and Scielo of the last 17 years (2003–2020). The keywords used were: "quality of life OR satisfaction" AND "complete denture OR conventional denture" AND "overdenture OR implant retained." Results: Six articles and two more were added by manual search. The population was 400 in the CCD and 412 for IOD. The mean age was 64.3 ± 6.41 years. The group was comprised of 283 men and 427 women. The scores obtained in the visual analog scale (VAS) before and after the treatment were statistically significant in favor of the IOD for overall satisfaction, (WMD: 12.329; 95% CI: 4.873 to 19.784, p‐value = 0.001), comfort, speech and stability. For esthetics and chewing there was non‐significant improvement while hygiene worsened for the IOD. For the comparison after the treatment between both treatment modalities a statistically significant improvement was found in overall satisfaction (WMD: 14.408; 95% CI: 8.589 to 20.226, p‐value < 0.001), comfort, speech, chewing and stability in favor of the IOD but not in esthetics or hygiene. Conclusions: This systematic review and meta‐analysis show the superiority of the IOD, despite is not achieved in all aspects. [ABSTRACT FROM AUTHOR]

Published
2021
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