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225 results on '"Izmirlian, Grant"'

2. Early detection of pancreatic cancer: Study design and analytical considerations in biomarker discovery and early phase validation studies

Author

Smith, Lynette M., Mahoney, Douglas W., Bamlet, William R., Yu, Fang, Liu, Suyu, Goggins, Michael G., Darabi, Sourat, Majumder, Shounak, Wang, Qiao-Li, Coté, Gregory A., Demeure, Michael J., Zhang, Zhen, Srivastava, Sudhir, Chawla, Akhil, Izmirlian, Grant, Olson, Janet E., Wolpin, Brian M., Genkinger, Jeanine M., Zaret, Kenneth S., Brand, Randall, Koay, Eugene J., and Oberg, Ann L.

Published
2024
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3. Crowd-sourced machine learning prediction of long COVID using data from the National COVID Cohort Collaborative

Author

Aggarwal, Ataes, Agor, Joseph, Al-Amery, Amera, Aminu, Oluwatobiloba, Anand, Adit, Antonescu, Corneliu, Arora, Mehak, Asaduzzaman, Sayed, Asmussen, Tanner, Baghbanzadeh, Mahdi, Baker, Frazier, Bangert, Bridget, Bekhet, Laila, Bhattacharya, Biplab, Blase, Jenny, Butzin-Dozier, Zachary, Caffo, Brian, Chang, Hao, Chen, Zeyuan, Chen, Jiandong, Chiang, Jeffrey, Cho, Peter, Cockrell, Robert, Combs, Parker, Coyle, Jeremy, Crosby, Ciara, Dai, Zongyu, Dai, Ran, Danesharasteh, Anseh, Yildirim, Elif, Delong, Grant, Demilt, Ryan, Deng, Kaiwen, Dey, Sanjoy, Dhamdhere, Rohan, Dickson, Andrew, Dijour, Phoebe, Dinh, Dong, Dixon, Richard, Domi, Albi, Dutta, Souradeep, Elizondo, Mirna, Ertem, Zeynep, Feuerwerker, Solomon, Fliss, Danica, Fowler, Jennifer, Fu, Sunyang, Gardner, Kelly, Getty, Neil, Ghalwash, Mohamed, Gloster, Logan, Greer, Phil, Guan, Yuanfang, Ham, Colby, Hanoudi, Samer, Harper, Jeremy, Hendrix, Nathaniel, Hershkovich, Leeor, Hightower, Jake, Hu, Junjie, Huang, Jiani, Huang, Yu, Huang, Tongtong, Hur, Junguk, Isgut, Monica, Ismail, Hamid, Izmirlian, Grant, Jang, Kuk, Jemiyo, Christianah, Jeong, Hayoung, Ji, Yunwen, Ji, Xiayan, Jiang, Ming, Jiang, Sihang, Jiang, Xiaoqian, Jiang, Yuye, Johnson, Akin, Analyst, Zach, Kapse, Saarthak, Kartoun, Uri, KC, Dukka, Fard, Zahra, Kosfeld, Tim, Krichevsky, Spencer, Kuo, Mike, Larie, Dale, Lederer, Lauren, Leng, Shan, Li, Ziyang, Li, Hongyang, Li, Haodong, Li, Jianfu, Li, Tiantian, Liang, Xinwen, Liang, Hengyue, Liu, Feifan, Liu, Daniel, Luo, Gang, Munia, Tamanna, Madduri, Ravi, Madhira, Vithal, Mani, Shivali, Mansourifard, Farzaneh, Matson, Robert, Mertens, Andrew, Metsis, Vangelis, Meyer, Pablo, Mikhailova, Catherine, Miller, Dante, Milo, Christopher, Mitchell, Elliot, Modanwal, Gourav, Moore, Ronald, Morgenthaler, David, Musal, Rasim, Naik, Mayur, Nalawade, Vinit, Narain, Rohan, Narendrula, Saideep, Obiri, Alena, Okawa, Satoshi, Okechukwu, Chima, Olorunnisola, Toluwanimi, Ossowski, Tim, Parekh, Harsh, Park, Jean, Patel, Saaya, Patterson, Jason, Paul, Chetan, Peng, Le, Perkins, Diana, Pokharel, Suresh, Poplavskiy, Dmytro, Pryor, Zach, Pungitore, Sarah, Qin, Hong, Rababa, Salahaldeen, Rahman, Mahbubur, Rahmani, Elior, Rahnavard, Gholamali, Raihan, Md, Rajendran, Suraj, Ravichandran, Sarangan, Reddy, Chandan, Reyes, Abel, Roghanizad, Ali, Rouffa, Sean, Ruan, Xiaoyang, Saha, Arpita, Sawant, Sahil, Schiaffino, Melody, Seira, Diego, Sengupta, Saurav, Shalaev, Ruslan, Shetty, Gaurav, Shi, Seraphina, Shinguyen, Linh, Singh, Karnika, Sinha, Soumya, Socia, Damien, Stalians, Halen, Stavropoulos, Charalambos, Strube, Jan, Subramanian, Devika, Sun, Jiehuan, Sun, Ju, Sun, Chengkun, Sundararajan, Prathic, Talebi, Salmonn, Tawiah, Edward, Tesic, Jelena, Thiess, Mikaela, Tian, Raymond, Torre-Healy; Ming-Tse Tsai, Luke, Tyus, David, Vardhan, Madhurima, Velingker, Neelay, Walzer, Benjamin, Walzer, Jacob, Wang, Junda, Wang, Lu, Wang, Will, Wang, Jonathan, Wang, Yisen, Weatherly, Chad, Wu, Fanyou, Wu, Yifeng, Wu, Yinjun, Xia, Fangfang, Yan, Hao, Yang, Zhichao, Ye, Biao, Yin, Rui, Yin, Changyu, Yoo, Yun, You, Albert, Yu, June, Zanaj, Martin, Zaiman, Zachary, Zhang, Kai, Zhang, Xiaoyi, Zhang, Tianmai, Zhao, Zixuan, Zhi, Degui, Zhong, Yishan, Zhou, Huixue, Zhou, Andrea, Zhu, Yuanda, Zhu, Yitan, Zhu, Sophie, Adams, Meredith, Alexander, Caleb, Amor, Benjamin, Anzalone, Alfred, Bates, Benjamin, Beasley, Will, Bennett, Tellen, Bissell, Mark, Boudreau, Eilis, Bozzette, Samuel, Bradwell, Katie, Bramante, Carolyn, Brown, Don, Burgoon, Penny, Buse, John, Callahan, Tiffany, Cato, Kenrick, Chapman, Scott, Chute, Christopher, Clark, Jaylyn, Clark, Marshall, Cooper, Will, Cottrell, Lesley, Crowley, Karen, Deacy, Mariam, Dillon, Christopher, Eichmann, David, Emmett, Mary, Erwin-Cohen, Rebecca, Francis, Patricia, French, Evan, Fuentes, Rafael, Gabriel, Davera, Gagnier, Joel, Garbarini, Nicole, Ge, Jin, Gersing, Kenneth, Girvin, Andrew, Gordon, Valery, Graves, Alexis, Guinney, Justin, Haendel, Melissa, Hayanga, J.W., Hendricks, Brian, Hernandez, Wenndy, Hill, Elaine, Hillegass, William, Hong, Stephanie, Housman, Dan, Hurley, Robert, Islam, Jessica, Jawa, Randeep, Johnson, Steve, Kamaleswaran, Rishi, Kibbe, Warren, Koraishy, Farrukh, Kostka, Kristin, Kurilla, Michael, Lee, Adam, Lehmann, Harold, Liu, Hongfang, Loomba, Johanna, Madlock-Brown; Sandeep Mallipattu, Charisse, Manna, Amin, Mariona, Federico, Marti, Emily, Martin, Greg, Mathew, Jomol, Mazzotti, Diego, McMurry, Julie, Mehta, Hemalkumar, Michael, Sam, Miller, Robert, Misquitta, Leonie, Moffitt, Richard, Morris, Michele, Murray, Kimberly, Northington, Lavance, O’Neil, Shawn, Olex, Amy, Palchuk, Matvey, Patel, Brijesh, Patel, Rena, Payne, Philip, Pfaff, Emily, Pincavitch, Jami, Portilla, Lili, Prior, Fred, Pyarajan, Saiju, Pyles, Lee, Qureshi, Nabeel, Robinson, Peter, Rutter, Joni, Sadan, Ofer, Safdar, Nasia, Saha, Amit, Saltz, Joel, Saltz, Mary, Schmitt, Clare, Setoguchi, Soko, Sharafeldin, Noha, Sharathkumar, Anjali, Sheikh, Usman, Sidky, Hythem, Sokos, George, Southerland, Andrew, Spratt, Heidi, Starren, Justin, Subbian, Vignesh, Suver, Christine, Takemoto, Cliff, Temple-O'Connor, Meredith, Topaloglu, Umit, Vedula, Satyanarayana, Walden, Anita, Walters, Kellie, Ward-Caviness, Cavin, Wilcox, Adam, Wilkins, Ken, Williams, Andrew, Wu, Chunlei, Zampino, Elizabeth, Zhang, Xiaohan, Zhu, Richard, Bergquist, Timothy, Tariq, Adbul, Philips, Rachael V., Pirracchio, Romain, van der Laan, Mark, Colford, John M., Jr., Hubbard, Alan, Gao, Jifan, Chen, Guanhua, Stein, Adam, Long, Qi, Holmes, John, Mowery, Danielle, Wong, Eric, Parekh, Ravi, Getzen, Emily, and Blase, Jennifer

Published
2024
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4. Average Power and $\lambda$-power in Multiple Testing Scenarios when the Benjamini-Hochberg False Discovery Rate Procedure is Used

Author

Izmirlian, Grant

Subjects
Statistics - Methodology
Abstract

We discuss several approaches to defining power in studies designed around the Benjamini-Hochberg (BH) false discovery rate (FDR) procedure. We focus primarily on the \textit{average power} and the $\lambda$-\textit{power}, which are the expected true positive fraction and the probability that the true positive fraction exceeds $\lambda$, respectively. We prove results concerning strong consistency and asymptotic normality for the positive call fraction (PCF), the true positive fraction (TPF) and false discovery fraction (FDF). Convergence of their corresponding expected values, including a convergence result for the average power, follow as a corollaries. After reviewing what is known about convergence in distribution of the errors of the plugin procedure, (Genovese, 2004), we prove central limit theorems for fully empirical versions of the PCF, TPF, and FDF, using a result for stopped stochastic processes. The central limit theorem (CLT) for the TPF is used to obtain an approximate expression for the $\lambda$-power, while the CLT for the FDF is used to introduce an approximate procedure for determining a suitably small nominal FDR that results in a speicified bound on the FDF with stipulated high probability. The paper also contains the results of a large simulation study covering a fairly substantial portion of the space of possible inputs encountered in application of the results in the design of a biomarker study, a micro-array experiment and a GWAS study., Comment: 49 pages, 2 figures, 9 tables

Published
2018

5. The Shrinkage Variance Hotelling $T^2$ Test for Genomic Profiling Studies

Author

Izmirlian, Grant

Subjects
Statistics - Methodology
Abstract

Designed gene expression micro-array experiments, consisting of several treatment levels with a number of replicates per level, are analyzed by applying simple tests for group differences at the per gene level. The gene level statistics are sorted and a criterion for selecting important genes which takes into account multiplicity is applied. A caveat arises in that true signals (genes truly over or under expressed) are "competing" with fairly large type I error signals. False positives near the top of a sorted list can occur when genes having very small fold-change are compensated by small enough variance to yield a large test statistic. One of the first attempts around this caveat as the development of "significance analysis of micro-arrays (SAM)", which used a modified t-type statistic thresholded against its permutation distribution. The key innovation of the modified t-statistic was the addition of a constant to the per gene standard errors in order to stabilize the coefficient of variation of the resulting test statistic. Since then, several authors have proposed the use of shrinkage variance estimators in conjunction with t-type, and more generally, ANOVA type tests at the gene level. Our new approach proposes the use of a shrinkage variance Hotelling T-squared statistic in which the per gene sample covariance matrix is replaced by a shrinkage estimate borrowing strength from across all genes. It is demonstrated that the new statistic retains the F-distribution under the null, with added degrees of freedom in the denominator. Advantages of this class of tests are (i) flexibility in that a whole family of hypothesis tests is possible (ii) the gains of the above-mentioned earlier innovations are enjoyed more fully. This paper summarizes our results and presents a simulation study benchmarking the new statistic against another recently proposed statistic.

Published
2017

6. Estimation of the relative risk following group sequential procedure based upon the weighted log-rank statistic

Author

Izmirlian, Grant

Subjects
Statistics - Methodology
Abstract

In this paper we consider a group sequentially monitored trial on a survival endpoint, monitored using a weighted log-rank (WLR) statistic with deterministic weight function. We introduce a summary statistic in the form of a weighted average logged relative risk and show that if there is no sign change in the instantaneous logged relative risk, there always exists a bijection between the WLR statistic and the weighted average logged relative risk. We show that this bijection can be consistently estimated at each analysis under a suitable shape assumption, for which we have listed two possibilities. We indicate how to derive a design-adjusted p-value and confidence interval and suggest how to apply the bias-correction method. Finally, we document several decisions made in the design of the NLST interim analysis plan and in reporting its results on the primary endpoint.

Published
2011
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15. Mortality results from a randomized prostrate-cancer screening trial

Author

Andriole, Gerald L., Grubb, Robert L. III, Buys, Saundra S., Chia, Davi, Church, Timothy R., Fouad Mona N., Gelmann, Edward P., Kvale, Paul A., Reding, Douglas J., Weissfeld, Joel L., Yokochi, Lance A., O'Brien, Barbara, Clapp, Jonathan D., Rathmell, Joshua M., Crawford, E. David, Riley,Thomas L., Kramer, Barnett S., Izmirlian, Grant, Hayes, Richard B., Miller, Anthony B., Pinsky, Paul F., Prorok, Philip C., Gohagan, John K., and Berg, Christine D.

Subjects
Market trend/market analysis, Mortality -- Prevention, Mortality -- Forecasts and trends, Cancer -- Diagnosis, Cancer -- Usage, Cancer -- Health aspects
Abstract

A study was conducted to investigate the efficacy of screening for prostrate cancer in reducing the incidence of mortality from prostrate cancer. Results indicate that screening was associated with no reduction in death during the first 7 years and the rate was not very different with those not having undergone screening.

Published
2009

20. Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy

Author

Schoen, Robert E., Pinsky, Paul F., Weissfeld, Joel L., Yokochi, Lance A., Church, Timothy, Laiyemo, Adeyinka O., Bresalier, Robert, Andriole, Gerald L., Buys, Saundra S., Crawford, David E., Fouad, Mona N., Isaacs, Claudine, Johnson, Christine C., Reding, Douglas J., OʼBrien, Barbara, Carrick, Danielle M., Wright, Patrick, Riley, Thomas L., Purdue, Mark P., Izmirlian, Grant, Kramer, Barnett S., Miller, Anthony B., Gohagan, John K., Prorok, Philip C., and Berg, Christine D.

Published
2012
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21. Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up

Author

Andriole, Gerald L., Crawford, E. David, Grubb, Robert L., III, Buys, Saundra S., Chia, David, Church, Timothy R., Fouad, Mona N., Isaacs, Claudine, Kvale, Paul A., Reding, Douglas J., Weissfeld, Joel L., Yokochi, Lance A., O’Brien, Barbara, Ragard, Lawrence R., Clapp, Jonathan D., Rathmell, Joshua M., Riley, Thomas L., Hsing, Ann W., Izmirlian, Grant, Pinsky, Paul F., Kramer, Barnett S., Miller, Anthony B., Gohagan, John K., and Prorok, Philip C.

Published
2012
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22. Screening by Chest Radiograph and Lung Cancer Mortality: The Prostate, Lung, Colorectal, and Ovarian (PLCO) Randomized Trial

Author

Oken, Martin M., Hocking, Willam G., Kvale, Paul A., Andriole, Gerald L., Buys, Saundra S., Church, Timothy R., Crawford, E. David, Fouad, Mona N., Isaacs, Claudine, Reding, Douglas J., Weissfeld, Joel L., Yokochi, Lance A., O’Brien, Barbara, Ragard, Lawrence R., Rathmell, Joshua M., Riley, Thomas L., Wright, Patrick, Caparaso, Neil, Hu, Ping, Izmirlian, Grant, Pinsky, Paul F., Prorok, Philip C., Kramer, Barnett S., Miller, Anthony B., Gohagan, John K., and Berg, Christine D.

Published
2011
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23. Effect of Screening on Ovarian Cancer Mortality: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial

Author

Buys, Saundra S., Partridge, Edward, Black, Amanda, Johnson, Christine C., Lamerato, Lois, Isaacs, Claudine, Reding, Douglas J., Greenlee, Robert T., Yokochi, Lance A., Kessel, Bruce, Crawford, E. David, Church, Timothy R., Andriole, Gerald L., Weissfeld, Joel L., Fouad, Mona N., Chia, David, O’Brien, Barbara, Ragard, Lawrence R., Clapp, Jonathan D., Rathmell, Joshua M., Riley, Thomas L., Hartge, Patricia, Pinsky, Paul F., Zhu, Claire S., Izmirlian, Grant, Kramer, Barnett S., Miller, Anthony B., Xu, Jian-Lun, Prorok, Philip C., Gohagan, John K., and Berg, Christine D.

Published
2011
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24. Sex Differences in the Prevalence of Mobility Disability in Old Age: The Dynamics of Incidence, Recovery, and Mortality

Author

Leveille, Suzanne G., Penninx, Brenda W.J.H., Melzer, David, Izmirlian, Grant, and Guralnik, Jack M.

Subjects
Disability -- Demographic aspects, Sex differences -- Analysis, Aged -- Patient outcomes, Health, Psychology and mental health, Seniors
Abstract

Objectives. This study examined sex differences in the prevalence of mobility disability in older adults according to the influences of three components of prevalence: disability incidence, recovery from disability, and mortality. Methods. Participants in a population-based study of older adults from three communities in the United States (N = 10,263) were studied for up to 7 years. Life table methods were used to estimate the influence of each of the three components of disability prevalence in women and men. Sex differences in probabilities for transition states were measured by relative risks derived from a single model using a Markov chain approach. Results. The proportion of disabled women increased from 22% of women aged 70 years to 81% of those aged 90 years. In men, comparable figures were 15% and 57%. Incidence had the greatest impact on the sex differences in disability prevalence until age 90 and older when recovery rates had a greater impact on differences in prevalence. Mortality differences in men and women had only a modest impact on sex differences in disability prevalence. These findings initially seemed to contradict striking sex differences observed in the relative risks for mortality in men compared with women. Subsequent graphical analyses showed that incidence rather than recovery or mortality largely accounted for sex differences in disability prevalence in old age. Conclusion. Disability incidence, recovery from disability, and mortality dynamically influence the sex differences in the prevalence of mobility disability. However, incidence has the greatest impact overall on the higher prevalence of disability in women compared with men.

Published
2000

31. Prostate cancer screening in the Prostate, Lung, Colorectal and Ovarian cancer screening trial: update on findings from the initial four rounds of screening in a randomized trial

Author

Grubb, Robert L., III, Pinsky, Paul F., Greenlee, Robert T., Izmirlian, Grant, Miller, Anthony B., Hickey, Thomas P., Riley, Thomas L., Mabie, Jerome E., Levin, David L., Chia, David, Kramer, Barnett S., Reding, Douglas J., Church, Timothy R., Yokochi, Lance A., Kvale, Paul A., Weissfeld, Joel L., Urban, Donald A., Buys, Saundra S., Gelmann, Edward P., Ragard, Lawrence R., Crawford, E. David, Prorok, Philip C., Gohagan, John K., Berg, Christine D., and Andriole, Gerald L.

Published
2008

35. Racial differences in muscle strength in disabled older women

Author

Rantanen, Taina, Guralnik, Jack M., Leveille, Suzanne, Izmirlian, Grant, Hirsch, Rosemarie, Simonsick, Eleanor, Ling, Shari, and Fried, Linda P.

Subjects
Muscle strength -- Research, Disabled women -- Research, Aged women -- Research, Health, Seniors
Abstract

This study examines racial differences in muscle strength, and associations of muscle strength to level of physical activity and severity of disability, among a community sample of 254 black and 665 white, moderately to severely disabled women aged 65 and older. Potential confounders that were adjusted for in the models included age, body weight and height, joint pain, number of chronic conditions, and socioeconomic status. Hand grip, hip flexion, and knee extension forces were measured using portable hand-held dynamometers in the participants' homes. Hand grip strength was measured as the maximal isometric force. Hip flexion and knee extension forces were measured as the greatest force the tester had to apply to break the isometric contraction. A declining strength gradient was observed with increasing severity of disability and for decreasing level of physical activity in both races. At equal levels of disability or physical activity, blacks had better hand grip and hip flexion strength, but knee extension strength did not differ by race. The greater hand grip and hip flexion strength found in black women may be related to their greater muscle mass and known racial differences in body dimensions. No consistent racial differences were observed in the relationship between physical activity and muscle strength, or muscle strength and disability, suggesting that the role of muscle strength in the disablement process does not differ between races. Physical activity and exercise programs may be feasible ways to prevent worsening of disability in blacks and whites.

Published
1998

36. Analysis of contraceptive discontinuation in six developing countries from durations of use at survey

Author

Izmirlian, Grant, Adewuyu, Alfred A., and Suchindran, C.M.

Subjects
Contraception -- Surveys, Developing countries -- Health aspects, Biological sciences, Sociology and social work
Abstract

A cross-national study of contraceptive discontinuation amongst married nonsterilized women in Egypt, Kenya, Sri Lanka, Bolivia, Zimbabwe and Thailand was undertaken, based on the Demographic and Health Surveys (DHS). Two approaximation techniques were used, local linear regression smoothing of a histogram estimate of use time at survey, and a proportional hazards Weibull distribution for the discontinuation probability function.

Published
1997

44. Consistent analytic representation of the two lowest potential energy surfaces for Li3, Na3, and K3.

Author

Thompson, Todd C., Izmirlian, Grant, Lemon, Stephen J., Truhlar, Donald G., and Mead, C. Alden

Subjects
*POTENTIAL energy surfaces, *SODIUM
Abstract

We present new analytic representations of ab initio interaction potentials for Li3, Na3, and K3. The analytic representations are based on a functional form that has the correct analytic behavior in its dependence on the nuclear coordinates, even in the vicinity of D3h conical intersections and for collinear geometries, and that reduces, when one atom is removed to infinity, to an accurate diatomic potential energy curve. We show that the new representation can be used to predict excited-state energies by analytic continuation of ground-state energies to a second Riemann sheet. We also report pseudorotation barriers, Jahn–Teller stabilization energies, and harmonic vibration frequencies. [ABSTRACT FROM AUTHOR]

Published
1985
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45. Educational Differences in the Prevalence of Mobility Disability in Old Age: The Dynamics of Incidence, Mortality, and Recovery

Author

Melzer, David, Izmirlian, Grant, Leveille, Suzanne G., and Guralnik, Jack M.

Subjects
Aged -- Demographic aspects, Disability -- Demographic aspects, Physically disabled aged -- Demographic aspects, Education -- Health aspects, Health, Psychology and mental health, Seniors
Abstract

Objectives. Older people with less education have substantially higher prevalence rates of mobility disability. This study aimed to establish the relative contributions of incidence, recovery rates, and death to prevalence differences in mobility disability associated with educational status. Methods. Data were from 3 sites of the Established Populations for Epidemiological Study of the Elderly, covering 8,871 people aged 65-84 years who were followed for up to 7 years. Participants were classified on years of education received and as disabled if they needed help or were unable to walk up or down stairs or walk half a mile. A Markov model computed relative risks, adjusting for the effects of repeated observations on the same individuals. Results. Differences between education groups in person-years lived with disability were large. The relative risk of incident disability in men with 0-7 years of education (vs. those with 12 or more years) was 1.65 (95% CI = 1.37-1.97) and in women was 1.70 (95% CI = 1.15-2.53). Both recovery risks and risks of death in those with disability were not significantly different across education groups in either gender. Discussion. Higher incidence of disability is the main contributor to the substantially higher prevalence of disability in older people of lower socioeconomic status. Efforts to reduce the disparity in disability rates by socioeconomic status in old age should focus mainly on preventing disability, because differences in the course of mobility disability after onset appear to play a limited role in the observed prevalence disparities.

Published
2001

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