Search

Your search keyword '"Izbicki, Jr"' showing total 818 results
Start Over Author "Izbicki, Jr"
818 results on '"Izbicki, Jr"'

1. Decentralized colorectal cancer care in Germany over the last decade is associated with high in-hospital morbidity and mortality

Author

Ghadban T, Reeh M, Bockhorn M, Grotelueschen R, Bachmann K, Grupp K, Uzunoglu FG, Izbicki JR, and Perez DR

Subjects
outcome, centralization, CRC, surgery, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Tarik Ghadban,* Matthias Reeh,* Maximilian Bockhorn, Rainer Grotelueschen, Kai Bachmann, Katharina Grupp, Faik G Uzunoglu, Jakob R Izbicki, Daniel R Perez Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany *These authors contributed equally to this work Purpose: Despite several national initiatives, centralization of cancer care in Germany remains insufficient for most malignancies. Currently, there is a plethora of centers, including 290 voluntary certified and audited colorectal cancer (CRC) centers by the end of 2017, in the nation with many patients still being treated outside of such centers. This study aimed to assess morbidity and mortality rates of surgical procedures for primary colorectal CRC in Germany over the last decade through a comprehensive unbiased analysis. Patients and methods: We performed an analysis of the national diagnosis-related group inpatient statistics from 2005 to 2015 including all German hospitals. All patients who underwent surgeries for primary CRC during the study period were included. Results: A total of 351,028 cases were analyzed (61.6% colonic and 38.4% rectal resections). The mortality rate of colonic resections remained high during the study period (4.9% in 2005 vs 4.5% in 2015; P=0.57). Reduced perioperative mortality after rectal surgery was observed only after 2012 compared to previous years (3.8% in 2005 vs 3.0% in 2015; P

Published
2019

2. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Author

Tintelnot J, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S, Gagliani N

Published
2023
Full Text
View/download PDF

3. Core Outcome Set for Surgical Trials in Gastric Cancer (GASTROS Study):International patient and healthcare professional consensus

Author

Alkhaffaf, B, Metryka, A, Blazeby, J M, Glenny, A-M, Adeyeye, A, Costa, P M, Diez Del Val, I, Gisbertz, S S, Guner, A, Law, S, Lee, H-J, Li, Z, Nakada, K, Reim, D, Vorwald, P, Baiocchi, G L, Allum, W, Chaudry, M A, Griffiths, E A, Williamson, P R, Bruce, I A, Li, S., He, Yl, Xu, Z., Xue, Y., Liang, H., Li, G., Zhao, E., Neumann, P., O’Neill, L., Guinan, E., Zanotti, D., de Manzoni, G., Hagens, Erc., van Berge Henegouwen, Mi., Lages, P., Onofre, S., Restrepo Nunez, Rm., Salcedo Cabanas, G., Posada Gonzalez, M., Marin Campos, C., Candas, B., Emre Baki, B., Selim Bodur, M., Yildirim, R., Burak Cekic, A., Brown, J., Hayes, K., Daher, I., Gianchandani Moorjani, Rh., Adetoyese Adeyeye, A., Sulaiman Olayide, A., Mitsuo Leon-Takahashi, A., Pueyo Rabanal, A., Peri, A., Boddy, A., Novotny, A., Charalabopoulos, A., Alemdar, A., Souadka, A., Rodrigues Gomes, Am., Lazaro, A., Maciel Da Silva, A., do Rosario da Conceicao Silva e Santos, A., Guidi, A., Silva Bernardes, Aj., Quinn, A., Isik, A., A Slipek, A., Candas Altinbas, B., Johnson Alegbeleye, B., Wool Eom, B., Frittoli, B., Lonsdale, B., Rogers, B., Ammori, Bj., Rau, B., Molteni, B., Byrne, Be., Villacıs- Bermeo, Ba., Villacıs Gallardo, Be., Kose, B., Sampedro Nogueira, Cj., Loureiro, C., Oliveira de Sousa, Cm., Collins, Cg., Nonso Ekwunife, C., Chukwunwendu Osuagwu, C., Wong, Cly., Winkler, C., Reim, D., Kjær, Dw., Cooper, D., Horner, D., Irvine, D., Bowrey, Dj., Chuter, Dj., Elliot, D., Mcghee, D., Toth, D., Ofner, D., Manatakis, Dk., Silveira Martins, Dr., Belt, Ejt., Cattaneo, E., Samadov, E., Colak, E., Treppiedi, E., Guglielmi, E., Redondo- Villahoz, E., Ciferri, E., Tiemens-de Graaf, E., Cocozza, E., Pape, E., Drozdov, Es., Enrico, F., Rashid, F., Sandri, Marco, Rosa, F., Mingol Navarro, F., Simionato Perrotta, F., Chan, Fsy., Saavedra Tomasich, Fd., Takeda, Fr., Farrell, F., Olanike Wuraola, F., Rosero, G., Bevilacqua, G., Baronio, G., Mura, G., D’Eugenio, G., Ortega-Perez, G., Tilt, G., Sutcliffe, G., Mureddu, G., Guerra Jacob, G., Daneri, H., Olufemi Gbenga, H., Okabe, H., Kingsford Smith, I., Olawale Lateef, I., Garosio, I., Hatipoglu, I., Gockel, I., Negoi, I., Min, Ish., Mesquita, Imm., Diez del Val, I., Leemhuis, Jhf., Gossage, Ja., Weindelmayer, J., Izbicki, Jr., McKenzie Manson, J., Kelly, J., Stoot, Jhmb., Haveman, Jw., Brown, Jd., Sultan, J., Hassall, J., van Sandick, J., Saunders, Jh., Clarke, Jk., Heisterkamp, J., Vargas, Ji., Couselo Villanueva, Jm., Ingmire, J., Mcewen, J., Galindo Alvarez, J., Turner, J., Peng, J., Roberts, K., Brandon, Kg., Mitchell, K., Mccarthy, K., Akhtar, K., Mikhailovich, Kn., Corbelli, L., Medeiros Milhomem, L., Solaini, L., Fengyuan, L., Xinchun, L., Timmermans, L., Porritt, L., Taglietti, L., Bonavina, L., F. Pinheiro L., de los Angeles Mayo Ossorio, M., Schiavo, M., Marchesiello, M., das Dores Vieira Leite, M., Demois, M., Di Felice, Mt., de Sousa, Md., Takahashi, M., Forshaw, M., Berselli, M., Paro, M., Usta, Ma., Yan, Mh., Pinchin, M., Caprioli, M., Rubbini, M., Cowen, M., Herrera Servin, Ma., Li, Mz., Sasako, M., Shukri Jahit, M., Ngonyoku Muhinga, M., Tareen, Ma., Ahmad, Mf., Bodur, Ms., Kaban, M., Farooq, N., Coburn, N., Cooper, N., Blencowe, Ns., Loria, N., de Vries, N., Adami Andreollo, N., Koksal, N., Zanini, N., Kreuser, N., Okkabaz, N., Damiana, O., Afuwape, O., Kayode Fasiku, O., Comensoli, O., F. Koroye O., Capener, P., Morgagni, P., Pernadas Lages, Pm., Wilkerson, Pm., Turner, P., Dutton, P., Hayes, P., Vorwald, P., Singh, P., Gan, Q., Kottayasamy Seenivasagam, R., Ayloor Seshadri, R., Guevara Castro, R., Douglas, R., Koshy, Rm., Yıldırım, R., Skipworth, Rje., Gould, Ra., Wetherill, Rc., Shaw, R., Burley, Ra., Palatucci, R., Racalbuto, R., Correia Casaca, Rm., Lagarde, Sm., Gana, S., Marietti, S., Qureshi, S., Morales-Conde, S., Molfino, S., Barreto, Sg., Turkyilmaz, S., Turan-Trabzon, S., Frisch, S., Castoldi, S., Belloni, S., Flisi, S., Galloway, S., Maria, Sr., Royston, S., Boyle, T., Sezer, T., Mengardo, V., Concepcion Martın, V., Lee Wills, V., Owen-Holt, V., Casagrande, V., Al-Khyatt, W., Jansen, W., Wang, W., Eshuis, W., Polkowski, Wp., Huang, X., Wang, X., Chen, Xz., Gonzalez Dominguez, Y., Wang, Y., Viswanath, Yks., He, Yl., Demir, Z., Na, Z., Surgery, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Imaging and biomarkers, Experimental Immunology, Clinical Immunology and Rheumatology, CCA -Cancer Center Amsterdam, and CCA - Cancer Treatment and quality of life

Subjects
medicine.medical_specialty, Manchester Cancer Research Centre, business.industry, gastric cancer, ResearchInstitutes_Networks_Beacons/mcrc, Delphi method, MEDLINE, Cancer, medicine.disease, Outcome (game theory), 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), 030220 oncology & carcinogenesis, Family medicine, gastros, Medicine, Surgery, 030212 general & internal medicine, Stage (cooking), Adverse effect, business, Set (psychology)
Abstract

Background Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, the aim of this study was to develop a core outcome set (COS)—a standardized group of outcomes important to key international stakeholders—that should be reported by future trials in this field. Methods Stage 1 of the study involved identifying potentially important outcomes from previous trials and a series of patient interviews. Stage 2 involved patients and healthcare professionals prioritizing outcomes using a multilanguage international Delphi survey that informed an international consensus meeting at which the COS was finalized. Results Some 498 outcomes were identified from previously reported trials and patient interviews, and rationalized into 56 items presented in the Delphi survey. A total of 952 patients, surgeons, and nurses enrolled in round 1 of the survey, and 662 (70 per cent) completed round 2. Following the consensus meeting, eight outcomes were included in the COS: disease-free survival, disease-specific survival, surgery-related death, recurrence, completeness of tumour removal, overall quality of life, nutritional effects, and ‘serious’ adverse events. Conclusion A COS for surgical trials in gastric cancer has been developed with international patients and healthcare professionals. This is a minimum set of outcomes that is recommended to be used in all future trials in this field to improve trial design and synthesis of evidence.

Published
2021

6. Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study

Author

Campa, D, Matarazzi, M, Greenhalf, W, Bijlsma, M, Saum, K-U, Pasquali, C, Van Laarhoven, H, Szentesi, A, Federici, F, Vodicka, P, Funel, N, Pezzilli, R, Bueno-De-Mesquita, HB, Vodickova, L, Basso, D, Obazee, O, Hackert, T, Soucek, P, Cuk, K, Kaiser, J, Sperti, C, Lovecek, M, Capurso, G, Mohelnikova-Duchonova, B, Khaw, K-T, König, A-K, Kupcinskas, J, Kaaks, R, Bambi, F, Archibugi, L, Mambrini, A, Cavestro, GM, Landi, S, Hegyi, P, Izbicki, JR, Gioffreda, D, Zambon, CF, Tavano, F, Talar-Wojnarowska, R, Jamroziak, K, Key, TJ, Fave, GD, Strobel, O, Jonaitis, L, Andriulli, A, Lawlor, RT, Pirozzi, F, Katzke, V, Valsuani, C, Vashist, YK, Brenner, H, Canzian, F, Campa, D., Matarazzi, M., Greenhalf, W., Bijlsma, M., Saum, K. -U., Pasquali, C., van Laarhoven, H., Szentesi, A., Federici, F., Vodicka, P., Funel, N., Pezzilli, R., Bueno-de-Mesquita, H. B., Vodickova, L., Basso, D., Obazee, O., Hackert, T., Soucek, P., Cuk, K., Kaiser, J., Sperti, C., Lovecek, M., Capurso, G., Mohelnikova-Duchonova, B., Khaw, K. -T., Konig, A. -K., Kupcinskas, J., Kaaks, R., Bambi, F., Archibugi, L., Mambrini, A., Cavestro, G. M., Landi, S., Hegyi, P., Izbicki, J. R., Gioffreda, D., Zambon, C. F., Tavano, F., Talar-Wojnarowska, R., Jamroziak, K., Key, T. J., Fave, G. D., Strobel, O., Jonaitis, L., Andriulli, A., Lawlor, R. T., Pirozzi, F., Katzke, V., Valsuani, C., Vashist, Y. K., Brenner, H., Canzian, F., Center of Experimental and Molecular Medicine, CCA - Cancer biology and immunology, Radiotherapy, Oncology, and AGEM - Re-generation and cancer of the digestive system

Subjects
Male, Cancer Research, pancreatic ductal adenocarcinoma, Polymorphism, Single Nucleotide, lymphocyte telomere length, genetic polymorphisms, association, Mendelian randomization, Oncology, Humans, genetic polymorphism, Lymphocytes, Telomerase, Telomere Shortening, Aged, Pancreatic Neoplasm, Ribonucleoprotein, Middle Aged, Telomere, Pancreatic Neoplasms, Europe, Ribonucleoproteins, Case-Control Studies, Female, Lymphocyte, Case-Control Studie, Carcinoma, Pancreatic Ductal, Genome-Wide Association Study, Human
Abstract

Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for several cancers. For pancreatic ductal adenocarcinoma (PDAC) consensus is lacking whether risk is associated with long or short telomeres. Mendelian randomization approaches have shown that a score built from SNPs associated with LTL could be used as a robust risk marker. We explored this approach in a large scale study within the PANcreatic Disease ReseArch (PANDoRA) consortium. We analyzed 10 SNPs (ZNF676-rs409627, TERT-rs2736100, CTC1-rs3027234, DHX35-rs6028466, PXK-rs6772228, NAF1-rs7675998, ZNF208-rs8105767, OBFC1-rs9420907, ACYP2-rs11125529 and TERC-rs10936599) alone and combined in a LTL genetic score (“teloscore”, which explains 2.2% of the telomere variability) in relation to PDAC risk in 2,374 cases and 4,326 controls. We identified several associations with PDAC risk, among which the strongest were with the TERT-rs2736100 SNP (OR = 1.54; 95%CI 1.35–1.76; p = 1.54 × 10 −10 ) and a novel one with the NAF1-rs7675998 SNP (OR = 0.80; 95%CI 0.73–0.88; p = 1.87 × 10 −6 , p trend = 3.27 × 10 −7 ). The association of short LTL, measured by the teloscore, with PDAC risk reached genome-wide significance (p = 2.98 × 10 −9 for highest vs. lowest quintile; p = 1.82 × 10 −10 as a continuous variable). In conclusion, we present a novel genome-wide candidate SNP for PDAC risk (TERT-rs2736100), a completely new signal (NAF1-rs7675998) approaching genome-wide significance and we report a strong association between the teloscore and risk of pancreatic cancer, suggesting that telomeres are a potential risk factor for pancreatic cancer.

Published
2019

8. Pancreatic Anastomosis After Pancreatoduodenectomy: A Position Statement By The International Study Group Of Pancreatic Surgery (ISGPS)

Author

Shrikhande, SV, Sivasanker, M, Vollmer, CM, Friess, H, Besselink, MG, Fingerhut, A, Yeo, CJ, Fernandez-delCastillo, C, Dervenis, C, Halloran, C, Gouma, DJ, Radenkovic, D, Asbun, HJ, Neoptolemos, JP, Izbicki, JR, Lillemoe, KD, Conlon, KC, Fernandez-Cruz, L, Montorsi, M, Bockhorn, M, Adham, M, Charnley, R, Carter, R, Hackert, T, Hartwig, W, Miao, Y, Sarr, M, Bassi, C, Büchler, MW, International Study Group of Pancreatic Surgery (ISGPS), AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, CCA -Cancer Center Amsterdam, and APH - Methodology

Subjects
medicine.medical_specialty, pancreatico-enteric anastomosis, medicine.medical_treatment, Fistula, Clinically relevant postoperative pancreatic fistula, pancreatoduodenectomy, management pancreatic remnant, pancreatico-enteric anastomosis, 030230 surgery, Anastomosis, Pancreaticoduodenectomy, 03 medical and health sciences, 0302 clinical medicine, management pancreatic remnant, medicine, Humans, Pancreatic duct, pancreatoduodenectomy, Framingham Risk Score, business.industry, General surgery, Patient Selection, Anastomosis, Surgical, Perioperative, medicine.disease, 3. Good health, Surgery, Clinically relevant postoperative pancreatic fistula, medicine.anatomical_structure, Pancreatic fistula, 030220 oncology & carcinogenesis, Practice Guidelines as Topic, business, Complication
Abstract

Background Clinically relevant postoperative pancreatic fistula (grades B and C of the ISGPS definition) remains the most troublesome complication after pancreatoduodenectomy. The approach to management of the pancreatic remnant via some form of pancreatico-enteric anastomosis determines the incidence and severity of clinically relevant postoperative pancreatic fistula. Despite numerous trials comparing diverse pancreatico-enteric anastomosis techniques and other adjunctive strategies (pancreatic duct stenting, somatostatin analogues, etc), currently, there is no clear consensus regarding the ideal method of pancreatico-enteric anastomosis. Methods An international panel of pancreatic surgeons working in well-known, high-volume centers reviewed the best contemporary literature concerning pancreatico-enteric anastomosis and worked to develop a position statement on pancreatic anastomosis after pancreatoduodenectomy. Results There is inherent risk assumed by creating a pancreatico-enteric anastomosis based on factors related to the gland (eg, parenchymal texture, disease pathology). None of the technical variations of pancreaticojejunal or pancreaticogastric anastomosis, such as duct-mucosa, invagination method, and binding technique, have been found to be consistently superior to another. Randomized trials and meta-analyses comparing pancreaticogastrostomy versus pancreaticojejunostomy yield conflicting results and are inherently prone to bias due to marked heterogeneity in the studies. The benefit of stenting the pancreatico-enteric anastomosis to decrease clinically relevant postoperative pancreatic fistula is not supported by high-level evidence. While controversial, somatostatin analogues appear to decrease perioperative complications but not mortality, although consistent data across the more than 20 studies addressing this topic are lacking. The Fistula Risk Score is useful for predicting postoperative pancreatic fistula as well as for comparing outcomes of pancreatico-enteric anastomosis across studies. Conclusion Currently, no specific technique can eliminate development of clinically relevant postoperative pancreatic fistula. While consistent practice of any standardized technique may decrease the rate of clinically relevant postoperative pancreatic fistula, experienced surgeons can have lower postoperative pancreatic fistula rates performing a variety of techniques depending on the clinical situation. There is no clear evidence on the benefit of internal or external stenting after pancreatico-enteric anastomosis. The use of somatostatin analogues may be important in decreasing morbidity after pancreatoduodenectomy, but it remains controversial. Future studies should focus on novel approaches to decrease the rate of clinically relevant postoperative pancreatic fistula with appropriate risk adjustment.

Published
2017

9. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation

Author

Campa, D, Pastore, M, Capurso, G, Hackert, T, Di Leo, M, Izbicki, JR, Khaw, K-T, Gioffreda, D, Kupcinskas, J, Pasquali, C, Macinga, P, Kaaks, R, Stigliano, S, Peeters, PH, Key, TJ, Talar-Wojnarowska, R, Vodicka, P, Valente, R, Vashist, YK, Salvia, R, Papaconstantinou, I, Shimizu, Y, Valsuani, C, Zambon, CF, Gazouli, M, Valantiene, I, Niesen, W, Mohelnikova-Duchonova, B, Hara, K, Soucek, P, Malecka-Panas, E, Bueno-de-Mesquita, HBA, Johnson, T, Brenner, H, Tavano, F, Fogar, P, Ito, H, Sperti, C, Butterbach, K, Latiano, A, Andriulli, A, Cavestro, GM, Busch, ORC, Dijk, F, Greenhalf, W, Matsuo, K, Lombardo, C, Strobel, O, König, A-K, Cuk, K, Strothmann, H, Katzke, V, Cantore, M, Mambrini, A, Oliverius, M, Pezzilli, R, Landi, S, Canzian, F, Other departments, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Campa, Daniele, Pastore, Manuela, Capurso, Gabriele, Hackert, Thilo, Di Leo, Milena, Izbicki, Jakob R, Khaw, Kay tee, Gioffreda, Domenica, Kupcinskas, Juoza, Pasquali, Claudio, Macinga, Peter, Kaaks, Rudolf, Stigliano, Serena, Peeters, Petra H, Key, Timothy J, Talar wojnarowska, Renata, Vodicka, Pavel, Valente, Roberto, Vashist, Yogesh K, Salvia, Roberto, Papaconstantinou, Ioanni, Shimizu, Yasuhiro, Valsuani, Chiara, Zambon, Carlo Federico, Gazouli, Maria, Valantiene, Irena, Niesen, Willem, Mohelnikova duchonova, Beatrice, Hara, Kazuo, Soucek, Pavel, Malecka panas, Ewa, Bueno de mesquita, H. Ba, Johnson, Theron, Brenner, Herman, Tavano, Francesca, Fogar, Paola, Ito, Hidemi, Sperti, Cosimo, Butterbach, Katja, Latiano, Anna, Andriulli, Angelo, Cavestro, GIULIA MARTINA, Busch, Olivier R. C, Dijk, Frederike, Greenhalf, William, Matsuo, Keitaro, Lombardo, Carlo, Strobel, Oliver, König, Anna katharina, Cuk, Katarina, Strothmann, Hendrik, Katzke, Verena, Cantore, Maurizio, Mambrini, Andrea, Oliverius, Martin, Pezzilli, Raffaele, Landi, Stefano, and Canzian, Federico

Subjects
Adult, Male, Cancer Research, endocrine system diseases, Chronic pancreatiti, pancreatic ductal adenocarcinoma, Adenocarcinoma, Polymorphism, Single Nucleotide, genetic polymorphisms, Risk Factors, Pancreatitis, Chronic, Biomarkers, Tumor, genetic polymorphism, Humans, Trypsin, Chronic, Polymorphism, Aged, Retrospective Studies, Tumor, Carcinoma, association, Nuclear Proteins, Single Nucleotide, Middle Aged, ACUTE PANCREATITIS, Prognosis, digestive system diseases, PANCREATIC CANCER, Pancreatic Neoplasms, Pancreatitis, Oncology, Pancreatic Ductal, Case-Control Studies, Chronic pancreatitis, Carcinoma, Pancreatic Ductal, Female, Follow-Up Studies, Trypsinogen, Biomarkers
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival of less than 6%. Chronic pancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share consistent number of epidemiologic risk factors, the aim of this study was to investigate whether specific CP risk loci also contribute to PDAC susceptibility. We selected five common SNPs (rs11988997, rs379742, rs10273639 rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium. We found a weak association between the minor allele of the PRSS1-PRSS2-rs10273639 and an increased risk of developing PDAC (ORhomozygous =1.19, 95% CI 1.02-1.38, p=0.023). Additionally all the SNPs confirmed statistically significant associations with risk of developing CP, the strongest being PRSS1-PRSS2-rs10273639 (ORheterozygous =0.51, 95% CI 0.39-0.67, p=1.10x10(-6) ) and MORC4-rs 12837024 (ORhomozygous =2.07 (1.55-2.77, ptrend =0.7x10(-11) ). Taken together, the results from our study do not support variants rs11988997, rs379742, rs10273639 rs2995271 and rs12688220 as strong predictors of PDAC risk, but further support the role of these SNPs in CP susceptibility. Our study suggests that CP and PDAC probably do not share genetic susceptibility, at least in terms of high frequency variants. This article is protected by copyright. All rights reserved.

Published
2017

10. Roboterassistierte Rektumchirurgie – Prospektive, internationale Analyse des perioperativen Outcomes von Patienten mit tief-sitzendem Rektumkarzinom

Author

Baukloh, JK, Bartolini, I, Mirasolo, V, Reeh, M, Izbicki, JR, Hiller, J, Bockhorn, M, Coratti, A, and Perez, D

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Der Vorteil der Roboter-assistierten (RC) gegenüber der konventionellen offenen Rektumchirurgie (OC), welche weiterhin den Standardeingriff in Deutschland (TAR+APR OC 74,0% vs. minimalinvasiv 26,0%; Statistisches Bundesamt DRG Statistik 2013) und Europa darstellt, wird[zum vollständigen Text gelangen Sie über die oben angegebene URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2016
Full Text
View/download PDF

11. Intraoperative quality assessment of tissue perfusion with indocyanine green (ICG) in a porcine model of mesenterial ischemia

Author

Duprée, A, Rieß, H, von Kroge, P, Izbicki, JR, Debus, S, Mann, O, Russ, D, Detter, C, and Wipper, S

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Intestinal ischemia as life-threatening event must be rapidly diagnosed and treated, but still intraoperative evaluation of bowel perfusion remains subjective and treatment strategies depend on the surgeon´s personal experience. Especially detection of resection margins is important[for full text, please go to the a.m. URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2016
Full Text
View/download PDF

15. Evidence for PTGER4, PSCA and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Hess, T, additional, Hamann, L, additional, Vashist, YK, additional, Butterbach, K, additional, Schmidt, T, additional, Krasniuk, I, additional, Höblinger, A, additional, Lingohr, P, additional, Ludwig, M, additional, Hagel, AF, additional, Schildberg, CW, additional, Veits, L, additional, Gyvyte, U, additional, Gonzalez-Carmona, MA, additional, Heinrichs, SK, additional, Becker, J, additional, Lordick, F, additional, Malfertheiner, P, additional, Möhler, M, additional, Pech, O, additional, Rodermann, E, additional, Izbicki, JR, additional, Kruschewski, M, additional, Ott, K, additional, Schumann, RR, additional, Vieth, M, additional, Mangold, E, additional, Kupcinskas, L, additional, Brenner, H, additional, Grimminger, P, additional, Bruns, C, additional, Büchler, MW, additional, Gockel, I, additional, Nöthen, MM, additional, Lippert, H, additional, Ridwelski, K, additional, Lanas, A, additional, Keller, G, additional, Knapp, M, additional, Leja, M, additional, Schumacher, J, additional, Kupcinskas, J, additional, García-González, MA, additional, and Venerito, M, additional

Published
2017
Full Text
View/download PDF

16. Gemeinsame genetische Ätiologie des Barrett-Ösophagus/-Karzinoms und der Adipositas

Author

Böhmer, AC, additional, Hecker, J, additional, May, A, additional, Gerges, C, additional, Venerito, M, additional, Schmidt, T, additional, Schmidt, C, additional, Manner, H, additional, Vashist, Y, additional, Benner, U, additional, Meyershofer, R, additional, Anders, M, additional, Vieth, M, additional, Hess, T, additional, Becker, J, additional, Knapp, M, additional, Moebus, S, additional, Nöthen, M, additional, Dietrich, A, additional, Thieme, R, additional, Ebigbo, A, additional, Messmann, H, additional, Peters, WH, additional, Büchler, MW, additional, Izbicki, JR, additional, Hölscher, AH, additional, Schumacher, B, additional, Weismüller, J, additional, Neuhaus, H, additional, Rösch, T, additional, Ell, C, additional, Gockel, I, additional, Fier, H, additional, and Schumacher, J, additional

Published
2017
Full Text
View/download PDF

20. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus

Author

Acosta, Jm, Amann, St, Andren Sandberg, A, Aranha, Gv, Asciutti, S, Banks, Pa, Barauskas, G, Baron, Th, Bassi, Claudio, Behrman, S, Behms, Ke, Belliappa, V, Berzin, Tm, Besselink, Mg, Bhasin, Dk, Biankin, A, Bishop, Md, Bollen, Tl, Bonini, Cj, Bradley, El, Buechler, M, Carter, Michael Ross, Cavestro, Gm, Chari, St, Chavez Rodriguez, Jj, da Cunha, Je, D'Agostino, H, De Campos, T, Delakidis, S, de Madaria, E, Deprez, Ph, Dervenis, C, Disario, Ja, Doria, C, Falconi, Massimo, Fernandez del Castillo, C, Freeny, Pc, Frey, Cf, Friess, H, Frossard, Jl, Fuchshuber, P, Gallagher, Sf, Gardner, Tb, Garg, Pk, Ghattas, G, Glasgow, R, Gonzalez, Ja, Gooszen, Hg, Gress, Tm, Gumbs, Aa, Halliburton, C, Helton, S, Hill, Mc, Horvath, Kd, Hoyos, S, Imrie, Cw, Isenmann, R, Izbicki, Jr, Johnson, Cd, Karagiannis, Ja, Klar, E, Kolokythas, O, Lau, J, Litvin, Aa, Longnecker, Ds, Lowenfels, Ab, Mackey, R, Mah'Moud, M, Malangoni, M, Mcfadden, Dw, Mishra, G, Moody, Fg, Morgan, De, Morinville, V, Mortele, Kj, Neoptolemos, Jp, Nordback, I, Pap, A, Papachristou, Gi, Parks, R, Pedrazolli, S, Pelaez Luna, M, Pezzilli, R, Pitt, Ha, Prosanto, C, Ramesh, H, Ramirez, Fc, Raper, Se, Rasheed, A, Reed, Dn, Romangnuolo, J, Rossaak, J, Sanabria, J, Sarr, Mg, Schaefer, C, Schmidt, J, Schmidt, Pn, Serrablo, A, Senkowski, Ck, Sharma, M, Sigman, Km, Singh, P, Stefanidis, G, Steinberg, W, Steiner, J, Strasberg, S, Strum, W, Takada, T, Tanaka, M, Thoeni, Rf, Tsiotos, Gg, Van Santvoort, H, Vaccaro, M, Vege, Ss, Villavicencio, Rl, Vrochides, D, Wagner, M, Warshaw, Al, Wilcox, Cm, Windsor, Ja, Wysocki, P, Yadav, D, Zenilman, Me, Zyromski, N. j., Banks, P, Bollen, T, Dervenis, C, Gooszen, H, Johnson, C, Sarr, M, Tsiotos, G, Vege, S, Cavestro, GIULIA MARTINA, and ACUTE PANCREATITIS CLASSIFICATION WORKING, Group

Subjects
Clinical deffinitions, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, Exacerbation, MEDLINE, Medicina Clínica, Disease, Guideline, Severity of Illness Index, Atlanta classification, Cystogastrostomy, purl.org/becyt/ford/3.2 [https], Severity of illness, medicine, Humans, Acute Disease, Disease Progression, Pancreatitis, Tomography, X-Ray Computed, Ranson criteria, Intensive care medicine, Tomography, business.industry, Gastroenterology, medicine.disease, Acute pancreatitis, X-Ray Computed, Surgery, Evaluation of complex medical interventions [NCEBP 2], purl.org/becyt/ford/3 [https], Medicina Critica y de Emergencia, business
Abstract

Background and objective: The Atlanta classification of acute pancreatitis enabled standardised reporting of research and aided communication between clinicians. Deficiencies identified and improved understanding of the disease make a revision necessary. Methods: A web-based consultation was undertaken in 2007 to ensure wide participation of pancreatologists. After an initial meeting, the Working Group sent a draft document to 11 national and international pancreatic associations. This working draft was forwarded to all members. Revisions were made in response to comments, and the web-based consultation was repeated three times. The final consensus was reviewed, and only statements based on published evidence were retained. Results: The revised classification of acute pancreatitis identified two phases of the disease: early and late. Severity is classified as mild, moderate or severe. Mild acute pancreatitis, the most common form, has no organ failure, local or systemic complications and usually resolves in the first week. Moderately severe acute pancreatitis is defined by the presence of transient organ failure, local complications or exacerbation of co-morbid disease. Severe acute pancreatitis is defined by persistent organ failure, that is, organ failure >48 h. Local complications are peripancreatic fluid collections, pancreatic and peripancreatic necrosis (sterile or infected), pseudocyst and walled-off necrosis (sterile or infected). We present a standardised template for reporting CT images. Conclusions: This international, web-based consensus provides clear definitions to classify acute pancreatitis using easily identified clinical and radiologic criteria. The wide consultation among pancreatologists to reach this consensus should encourage widespread adoption. Fil: Banks, Peter A.. Harvard Medical School; Estados Unidos Fil: Bollen, Thomas L.. St Antonius Hospital; Países Bajos Fil: Dervenis, Christos. Agia Olga Hospital; Grecia Fil: Gooszen, Hein G.. Radboud Universiteit Nijmegen; Países Bajos Fil: Johnson, Colin D.. University Hospital Southampton; Reino Unido Fil: Sarr, Michael G.. Mayo Clinic; Estados Unidos Fil: Tsiotos, Gregory G.. Metropolitan Hospital; Grecia Fil: Vege, Santhi Swaroop. Metropolitan Hospital; Grecia Fil: Vaccaro, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Acute Pancreatitis Classification Working Group. No especifica

Published
2013

21. Therapeutischer Effekte der Gabe von zellfreiem Hämoglobin bei schwerer akuter Pankreatitis

Author

Bachmann, K, Freitag, M, Tomkötter, L, Koops, S, Strate, T, Izbicki, JR, and Mann, O

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die akute Pankreatitis ist eine Erkrankung, die klinisch zum Teil fulminant verläuft. Trotz verbesserter intensivmedizinischer Therapieregime liegt die Letalität der hämorrhagisch-nekrotisierenden Verlaufsformen der akuten Pankreatitis immer noch zwischen 40% und 60%.[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
Full Text
View/download PDF

22. Prognostic Impact of Perineural, Blood and Lymph Vessel Invasion for Esophageal Cancer Patients

Author

Tachezy, M, Gebauer, F, Kutup, A, Izbicki, JR, and Vashist, YK

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Esophageal cancer is one of the most aggressive tumor types and associated with a poor prognosis of the patients. Only few studies with inconsistent results have investigated the prognostic impact of tumor-micro-invasion in blood (AI) and lymphatic vessels (LVI) and perineural invasion[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
Full Text
View/download PDF

23. Rekonstruktionsverfahren nach Whipple’scher Operation – Tradition vs. Gewinnmaximierung

Author

Uzunoglu, FG, Reeh, M, Wollstein, R, Vashist, YK, König, AM, Izbicki, JR, and Bockhorn, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Hohe Raten an chirurgischen Komplikationen, insbesondere die Entstehung von Pankreasfisteln und Magenentleerungsstörungen, stellen weiterhin ein ungelöstes Problem in der Pankreaschirurgie dar. Bisher konnte sich keine der verschiedenen 1-, 2- und 3-Schlingenrekonstruktionen nach[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
Full Text
View/download PDF

24. Therapeutic management of esophageal anastomotic leakage after subtotal esophagectomy for esophageal carcinoma – institutional experience of a high volume centre

Author

Tachezy, M, Tomkötter, L, Gebauer, F, Vashist, Y, Bockhorn, M, Izbicki, JR, and Yekebas, E

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Esophagectomy is presently the gold standard in the treatment of localized esophageal cancer. The surgical treatment is associated with a high rate of morbidity and mortality, caused, amongst others, by anastomotic leaks. We evaluate our management strategies and outcome of anastomotic[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
Full Text
View/download PDF

25. Langzeit-Follow-Up nach Stapler Haemorrhoidopexie im Vergleich zu Milligan-Morgan

Author

Kim, J, Vashist, Y, Grotelüschen, R, Yekebas, E, Izbicki, JR, and Kutup, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Stapler-Hämorrhoidopexie (SH) hat bei Patienten mit symptomatischen Hämorrhoiden ihren Platz als operatives Behandlungsverfahren mit sehr guten Ergebnissen in den ersten postoperativen Jahren gefunden. Nur wenige Langzeitergebnisse liegen jedoch vor. Diese Studie vergleicht[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
Full Text
View/download PDF

26. Das therapeutische Dilemma konservativ nicht beherrschbarer Schmerzen bei Patienten mit chronischer Pankreatitis und porto-cavalen Umgehungskreisläufen

Author

Gebauer, F, Bockhorn, M, Mann, O, Yekebas, EF, and Izbicki, JR

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Im Verlauf einer chronischen Pankreatitis (CP) kann es zu Pfortaderthrombosen mit konsekutivem extrahepatischen Pfortaderhochdruck (EPH) kommen, dies kann zur Ausbildung porto-cavaler Umgehungskreisläufe (EPH-PCU) führen. Unter dieser Konstellation gelten Operationen als risikoreich,[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
Full Text
View/download PDF

27. Allogene Bluttransfusion ist ein prognostischer Faktor für das perioperative Outcome und Langzeitüberleben bei Ösophaguskarzinom

Author

Zehler, O, Vashist, YK, Dedow, J, Kutup, A, Yekebas, EF, and Izbicki, JR

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Transfusion von allogenem Blut ist mit erhöhter Morbidität und schlechtem Langzeitüberleben bei verschiedenen Karzinomen assoziiert. Ziel dieser Studie war es, die potentielle prognostische Rolle von allogener Bluttransfusion (aBT) in einem homogenen Ösophaguskarzinompatientenkollektiv[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
Full Text
View/download PDF

28. Der 'simple risk score' ist ein Prädiktor für Morbidität, Mortalität und Langzeitüberleben bei reseziertem Ösophaguskarzinom ohne neoadjuvante und adjuvante Therapie

Author

Metze, J, Vashist, YK, Kutup, A, König, A, Gebauer, F, Zehler, O, Bockhorn, M, Yekebas, EF, and Izbicki, JR

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Ösophaguschirurgie ist auch heute noch mit beträchtlicher Morbidität und Mortalität behaftet. Das Langzeitüberleben bei Ösophaguskarzinom ist unbefriedigend. Es besteht ein Mangel an prognostischen Markern bei Ösophaguskarzinom. Ziel dieser Arbeit war[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
Full Text
View/download PDF

29. Hemmung von YB-1 als neuer therapeutischer Ansatz zur Verringerung der Expression von EGFR, HER-2 und IGF-IR im Ösophaguskarzinom

Author

Thieltges, S, Kalinina, T, Vashist, YK, Simon, R, Izbicki, JR, and Yekebas, EF

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das Y-box bindende Protein 1 (YB-1) ist ein onkogener Transkriptionsfaktor, der in mehreren malignen Geweben, einschließlich dem Mammakarzinom und dem nicht kleinzelligen Bronchialkarzinom, hoch exprimiert wird. Obwohl dies auf eine Beteiligung von YB-1 bei der Tumorprogression schließen[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
Full Text
View/download PDF

30. Quo vadis STARR? Ein prospektives 5-Jahres-Follow-up der STARR-Operation

Author

Zehler, O, Steffani, K, Vashist, Y, Bachmann, K, Kutup, A, and Izbicki, JR

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Stapled Transanal Rectal Resection (STARR) ist eine néue einfache Methode zur Therapie bei einer obstruktiven Defäkationsstörung (ODS). Die Alternativen zur Behandlung der ODS sind transvaginale, transperitoneale oder abdominelle Verfahren; alle 3 Verfahren sind zeitaufwendiger[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009
Full Text
View/download PDF

31. Operation nach Merendino – Rescue-OP bei Megaösophagus bei therapierefraktärer Achalasie

Author

Busch, CP, Strate, TG, Mann, O, Schneider, CG, Busch, CHT, Yekebas, E, and Izbicki, JR

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Achalasie ist eine Motilitätsstörung der Speiseröhre, welche durch Dysphagie, Regurgitation, Thoraxschmerzen und Gewichtsverlust symptomatisch wird. Die Pathogenese ist bislang nicht endgültig geklärt. Neben der medikamentösen Therapie, stehen die pneumatische[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009
Full Text
View/download PDF

32. Stellenwert der Pankreasresektion mit arterieller en-bloc Gefäßresektion beim lokal fortgeschrittenen Pankreaskarzinom

Author

Bockhorn, M, Burdelski, C, Vashist, Y, Kutup, A, König, A, Cataldegirmen, G, Marx, A, Izbicki, JR, and Yekebas, E

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Im Gegensatz zur umschriebenen Tumorinfiltration in die V. mesenterica sup./ V. portae, bei denen die Resektion deutliche Überlebensvorteile bietet, ist das Vorgehen beim lokal fortgeschrittenen Pankreaskarzinom mit Infiltration des Tr. coeliacus und seiner Äste oder der A.[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results