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1,465 results on '"Ixazomib"'

18. Ixazomib, Lenalidomide, and Combination for Maintenance in NDMM Patients

Author

Peking University Third Hospital, Beijing Jishuitan Hospital, Beijing Chao Yang Hospital, Xuanwu Hospital, Beijing, Peking University First Hospital, Jilin Provincial Tumor Hospital, Second Hospital of Shanxi Medical University, The First Affiliated Hospital of Shanxi Medical University, Tianjin Medical University General Hospital, The First Affiliated Hospital of Anhui Medical University, Shanxi Bethune Hospital, Beijing Hospital, and Junling Zhuang, Professor

Published
2024

44. Proteasome inhibitor‐associated histiocytoid Sweet's syndrome: Clinical and histological similarities to Nakajo‐Nishimura syndrome suggest a potential mechanism.

Author

Cho, Ryang, Nakajima, Saeko, Kaku, Yo, Tezuka, Junko, Fujimoto, Masakazu, Kambe, Naotomo, and Kabashima, Kenji

Abstract

Histiocytoid Sweet's syndrome (HSS) is a variant of Sweet's syndrome (SS) that clinically resembles SS but differs histologically by infiltrates, predominantly composed of immature cells of the myeloid lineage. Medications such as proteasome inhibitors have been reported to cause HSS but there has been little discussion on the underlying mechanism. Here we report two cases of HSS associated with a proteasome inhibitor. Both patients were on ixazomib for the treatment of multiple myeloma and presented with acute erythematous plaques on the upper half of the body. Pathological findings were consistent with HSS. Similarities between proteasome inhibitor‐induced HSS and Nakajo‐Nishimura syndrome, an inherited inflammatory disease, can be identified both clinically and histologically, suggesting a potential explanation of the mechanism behind proteasome inhibitor‐associated HSS. [ABSTRACT FROM AUTHOR]

Published
2024
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