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368 results on '"Iwato, Koji"'

7. Risk Stratification and Prognosticators of Acute Myeloid Leukemia with Myelodysplasia-Related Changes in Patients Undergoing Allogeneic Stem Cell Transplantation: A Retrospective Study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation

Author

Harada, Kaito, Konuma, Takaaki, Machida, Shinichiro, Mori, Jinichi, Aoki, Jun, Uchida, Naoyuki, Ohashi, Kazuteru, Fukuda, Takahiro, Tanaka, Masatsugu, Ikegame, Kazuhiro, Ozawa, Yukiyasu, Iwato, Koji, Eto, Tetsuya, Onizuka, Makoto, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Yano, Shingo

Published
2019
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8. Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Study of Japanese Registry Data

Author

Yoshinaga, Noriyoshi, Kanda, Junya, Aisa, Yoshinobu, Hagiwara, Shotaro, Mori, Takehiko, Fukuda, Takahiro, Ishida, Yoji, Hashimoto, Hisako, Iwato, Koji, Kanda, Yoshinobu, Kurokawa, Mineo, Nakazawa, Hideyuki, Ota, Shuichi, Uchida, Naoyuki, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Takaori-Kondo, Akifumi

Published
2018
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9. Prognostic Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in Adults with Chronic Myelomonocytic Leukemia: A Nationwide Retrospective Analysis in Japan

Author

Itonaga, Hidehiro, Aoki, Kazunari, Aoki, Jun, Ishikawa, Takayuki, Ishiyama, Ken, Uchida, Naoyuki, Sakura, Toru, Ohashi, Kazuteru, Kurokawa, Mineo, Ozawa, Yukiyasu, Matsuoka, Ken-ichi, Nakamura, Yukinori, Kimura, Fumihiko, Iwato, Koji, Nawa, Yuichiro, Hirokawa, Makoto, Kato, Koji, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Miyazaki, Yasushi

Published
2018
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11. Clinical significance of low-dose total body irradiation in HLA-mismatched reduced-intensity stem cell transplantation

Author

Fujiwara, Shin-ichiro, Kanda, Junya, Tatara, Raine, Ogawa, Hiroyasu, Fukuda, Takahiro, Okumura, Hirokazu, Ohashi, Kazuteru, Iwato, Koji, Ueda, Yasunori, Ishiyama, Ken, Eto, Tetsuya, Matsuoka, Ken-ichi, Nakamae, Hirohisa, Onizuka, Makoto, Atsuta, Yoshiko, Kanda, Yoshinobu, and on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation

Published
2019
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12. Increased opportunity for prolonged survival after allogeneic hematopoietic stem cell transplantation in patients aged 60–69 years with myelodysplastic syndrome

Author

Itonaga, Hidehiro, Ishiyama, Ken, Aoki, Kazunari, Aoki, Jun, Ishikawa, Takayuki, Uchida, Naoyuki, Ohashi, Kazuteru, Ueda, Yasunori, Fukuda, Takahiro, Sakura, Toru, Ohno, Yuju, Iwato, Koji, Okumura, Hirokazu, Kondo, Tadakazu, Ichinohe, Tatsuo, Takanashi, Minoko, Atsuta, Yoshiko, and Miyazaki, Yasushi

Published
2019
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13. Short-term clinical outcomes after HLA 1-locus mismatched uPBSCT are similar to that after HLA-matched uPBSCT and uBMT

Author

Fuji, Shigeo, Miyamura, Koichi, Kanda, Yoshinobu, Fukuda, Takahiro, Kobayashi, Takeshi, Ozawa, Yukiyasu, Iwato, Koji, Uchida, Naoyuki, Eto, Tetsuya, Ashida, Takashi, Mori, Takehiko, Sawa, Masashi, Ichinohe, Tatsuo, Atsuta, Yoshiko, Kanda, Junya, and the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation

Published
2019
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18. Allogeneic Hematopoietic Cell Transplantation for Leukemic Transformation Preceded by Philadelphia Chromosome–Negative Myeloproliferative Neoplasms: A Nationwide Survey by the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation

Author

Takagi, Shinsuke, Masuoka, Kazuhiro, Uchida, Naoyuki, Kurokawa, Mineo, Nakamae, Hirohisa, Imada, Kazunori, Iwato, Koji, Ichinohe, Tatsuo, Atsuta, Yoshiko, Takami, Akiyoshi, and Yano, Shingo

Published
2016
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19. A Comparison of Outcomes for Cord Blood Transplantation and Unrelated Bone Marrow Transplantation in Adult Aplastic Anemia

Author

Kuwatsuka, Yachiyo, Kanda, Junya, Yamazaki, Hirohito, Mori, Takehiko, Miyamura, Koichi, Kako, Shinichi, Uchida, Naoyuki, Ohashi, Kazuteru, Ozawa, Yukiyasu, Takahashi, Yoshiyuki, Kato, Chiaki, Iwato, Koji, Ishiyama, Ken, Kobayashi, Hikaru, Eto, Tetsuya, Kahata, Kaoru, Kato, Jun, Miyamoto, Toshihiro, Kato, Koji, Mori, Shinicihro, Atsuta, Yoshiko, Kimura, Fumihiko, and Kanda, Yoshinobu

Published
2016
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21. Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia: A Japanese National Registry Study

Author

Arima, Nobuyoshi, Nakamura, Fumiaki, Yabe, Toshio, Tanaka, Junji, Fuji, Shigeo, Ohashi, Kazuteru, Fukuda, Takahiro, Miyamura, Koichi, Iwato, Koji, Eto, Tetsuya, Mori, Takehiko, Kobayashi, Naoki, Hoshino, Takumi, Kato, Chiaki, Kanamori, Heiwa, Nakamae, Hirohisa, Atsuta, Yoshiko, Morishima, Yasuo, and Kanda, Yoshinobu

Published
2016
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22. Impact of HLA Mismatch Direction on the Outcome of Unrelated Bone Marrow Transplantation: A Retrospective Analysis from the Japan Society for Hematopoietic Cell Transplantation

Author

Kanda, Junya, Ichinohe, Tatsuo, Fuji, Shigeo, Maeda, Yoshinobu, Ohashi, Kazuteru, Fukuda, Takahiro, Miyamura, Koichi, Iwato, Koji, Eto, Tetsuya, Nakamae, Hirohisa, Kobayashi, Naoki, Mori, Takehiko, Mori, Shin-ichiro, Morishima, Yasuo, Atsuta, Yoshiko, and Kanda, Yoshinobu

Published
2015
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23. Allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia who had central nervous system involvement: a study from the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation

Author

Shigematsu, Akio, Kako, Shinichi, Mitsuhashi, Kenjiro, Iwato, Koji, Uchida, Naoyuki, Kanda, Yoshinobu, Fukuda, Takahiro, Sawa, Masashi, Senoo, Yasushi, Ogawa, Hiroyasu, Miyamura, Koichi, Takada, Satoru, Nagamura-Inoue, Tokiko, Morishima, Yasuo, Ichinohe, Tatsuo, Atsuta, Yoshiko, Mizuta, Shuichi, and Tanaka, Junji

Published
2017
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24. Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia

Author

Yamasaki, Satoshi, Hirakawa, Akihiro, Aoki, Jun, Uchida, Naoyuki, Fukuda, Takahiro, Ogawa, Hiroyasu, Ohashi, Kazuteru, Kondo, Tadakazu, Eto, Tetsuya, Kanamori, Heiwa, Okumura, Hirokazu, Iwato, Koji, Ichinohe, Tatsuo, Kanda, Junya, Onizuka, Makoto, Kuwatsuka, Yachiyo, Yanada, Masamitsu, Atsuta, Yoshiko, Takami, Akiyoshi, and Yano, Shingo

Published
2017
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28. A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective nationwide survey

Author

Sakai, Rika, Taguri, Masataka, Oshima, Kumi, Mori, Takehiko, Ago, Hiroatsu, Adachi, Souichi, Morita, Satoshi, Taniguchi, Shuichi, Fukuda, Takahiro, Ohashi, Kazuteru, Eto, Tetsuya, Miyamura, Koichi, Iwato, Koji, Kobayashi, Naoki, Kanamori, Heiwa, Morishima, Yasuo, Nagamura-Inoue, Tokiko, Sakamaki, Hisashi, Atsuta, Yoshiko, and Murata, Makoto

Published
2016
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30. Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study

Author

Kanda, Junya, Saji, Hiroh, Fukuda, Takahiro, Kobayashi, Takeshi, Miyamura, Koichi, Eto, Tetsuya, Kurokawa, Mineo, Kanamori, Heiwa, Mori, Takehiko, Hidaka, Michihiro, Iwato, Koji, Yoshida, Takashi, Sakamaki, Hisashi, Tanaka, Junji, Kawa, Keisei, Morishima, Yasuo, Suzuki, Ritsuro, Atsuta, Yoshiko, and Kanda, Yoshinobu

Published
2012
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31. Impact of age on outcomes of allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in elderly patients with acute myeloid leukemia

Author

Aoki, Jun, Kanamori, Heiwa, Tanaka, Masatsugu, Yamasaki, Satoshi, Fukuda, Takahiro, Ogawa, Hiroyasu, Iwato, Koji, Ohashi, Kazuteru, Okumura, Hirokazu, Onizuka, Makoto, Maesako, Yoshitomo, Teshima, Takanori, Kobayashi, Naoki, Morishima, Yasuo, Hirokawa, Makoto, Atsuta, Yoshiko, Yano, Shingo, and Takami, Akiyoshi

Published
2016
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32. Allogeneic stem cell transplantation for adult Philadelphia chromosome–negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission

Author

Nishiwaki, Satoshi, Inamoto, Yoshihiro, Sakamaki, Hisashi, Kurokawa, Mineo, Iida, Hiroatsu, Ogawa, Hiroyasu, Fukuda, Takahiro, Ozawa, Yukiyasu, Kobayashi, Naoki, Kasai, Masanobu, Mori, Takehiko, Iwato, Koji, Yoshida, Takashi, Onizuka, Makoto, Kawa, Keisei, Morishima, Yasuo, Suzuki, Ritsuro, Atsuta, Yoshiko, and Miyamura, Koichi

Published
2010
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33. Outcomes of Patients Who Undergo Transfusion of Fresh Frozen Plasma: A Prospective, Observational, Multicentre Cohort Study in Hiroshima, Japan

Author

Sugiyama, Aya, primary, Fujii, Teruhisa, additional, Okikawa, Yoshiko, additional, Sasaki, Fumie, additional, Okajima, Masazumi, additional, Hidaka, Hidekuni, additional, Iwato, Koji, additional, Sato, Kazuyoshi, additional, Kokubunji, Akira, additional, Takata, Noboru, additional, Yamamoto, Masahiro, additional, and Tanaka, Junko, additional

Published
2021
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34. Allogeneic haematopoietic cell transplantation with reduced-intensity conditioning for elderly patients with advanced myelodysplastic syndromes: a nationwide study

Author

Aoki, Kazunari, Ishikawa, Takayuki, Ishiyama, Ken, Aoki, Jun, Itonaga, Hidehiro, Fukuda, Takahiro, Kakihana, Kazuhiko, Uchida, Naoyuki, Ueda, Yasunori, Eto, Tetsuya, Mori, Takehiko, Kondo, Tadakazu, Iwato, Koji, Morishima, Yasuo, Tanaka, Junji, Atsuta, Yoshiko, and Miyazaki, Yasushi

Published
2015
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35. Outcomes of Patients Who Undergo Transfusion of Fresh Frozen Plasma: A Prospective, Observational, Multicentre Cohort Study in Hiroshima, Japan

Author

Sugiyama,Aya, Fujii,Teruhisa, Okikawa,Yoshiko, Sasaki,Fumie, Okajima,Masazumi, Hidaka,Hidekuni, Iwato,Koji, Sato,Kazuyoshi, Kokubunji,Akira, Takata,Noboru, Yamamoto,Masahiro, Tanaka,Junko, Sugiyama,Aya, Fujii,Teruhisa, Okikawa,Yoshiko, Sasaki,Fumie, Okajima,Masazumi, Hidaka,Hidekuni, Iwato,Koji, Sato,Kazuyoshi, Kokubunji,Akira, Takata,Noboru, Yamamoto,Masahiro, and Tanaka,Junko

Abstract

Aya Sugiyama,1 Teruhisa Fujii,2,3 Yoshiko Okikawa,4 Fumie Sasaki,5 Masazumi Okajima,3,6 Hidekuni Hidaka,3,7 Koji Iwato,3,8 Kazuyoshi Sato,3,9 Akira Kokubunji,3,10 Noboru Takata,3,11 Masahiro Yamamoto,3,12 Junko Tanaka1,3 1Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; 2Division of Transfusion Medicine, Hiroshima University Hospital, Hiroshima, Japan; 3Joint Committee for Blood Transfusion Therapy in Hiroshima Prefecture, Hiroshima, Japan; 4Department of Oncology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; 5Division of Laboratory, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; 6Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; 7Division of Surgical Services, Fukuyama City Hospital, Hiroshima, Japan; 8Department of Hematology, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, Hiroshima, Japan; 9Division of Laboratory, Shobara Red Cross Hospital, Shobara, Japan; 10Department of Medical Science and Technology, Faculty of Health Sciences, Hiroshima International University, Hiroshima, Japan; 11Oda Internal Medical Clinic, Hiroshima, Japan; 12Hiroshima Red Cross Blood Centre, Hiroshima, JapanCorrespondence: Teruhisa FujiiDivision of Transfusion Medicine, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ward, Hiroshima, 734-8551, JapanTel +81-82-257-5581Email terchan@hiroshima-u.ac.jpPurpose: Given the chronic shortage of blood for transfusion in Japan, promotion of appropriate use of fresh frozen plasma (FFP) urgently needs to be addressed by the national blood project in Japan. Whether FFP transfusions are administered appropriately in Japan is currently unclear. In this study, we aimed to investigate the outcomes of patients who undergo FFP transfusion and the appropriateness of use of FFP.Patients and Methods: This multicentre, prospective, observational cohort study

Published
2021

37. Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia

Author

Shigematsu, Akio, Tanaka, Junji, Suzuki, Ritsuro, Atsuta, Yoshiko, Kawase, Takakazu, Ito, Yoichi M., Yamashita, Takuya, Fukuda, Takahiro, Kumano, Keiki, Iwato, Koji, Yoshiba, Fumiaki, Kanamori, Heiwa, Kobayashi, Naoki, Fukuhara, Takashi, Morishima, Yasuo, and Imamura, Masahiro

Published
2011
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41. Impact of Cytogenetics on Outcome of Stem Cell Transplantation for Acute Myeloid Leukemia in First Remission: A Large-Scale Retrospective Analysis of Data from the Japan Society for Hematopoietic Cell Transplantation

Author

Ogawa, Hiroyasu, Ikegame, Kazuhiro, Kawakami, Manabu, Takahashi, Satoshi, Sakamaki, Hisashi, Karasuno, Takahiro, Sao, Hiroshi, Kodera, Yoshihisa, Hirabayashi, Noriyuki, Okamoto, Shinichiro, Harada, Mine, Iwato, Koji, Maruta, Atsuo, Tanimoto, Mitsune, and Kawa, Keisei

Published
2004
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42. Impact of a single human leucocyte antigen (HLA) allele mismatch on the outcome of unrelated bone marrow transplantation over two time periods. A retrospective analysis of 3003 patients from the HLA Working Group of the Japan Society for Blood and Marrow Transplantation

Author

Kanda, Yoshinobu, Kanda, Junya, Atsuta, Yoshiko, Maeda, Yoshinobu, Ichinohe, Tatsuo, Ohashi, Kazuteru, Fukuda, Takahiro, Miyamura, Koichi, Iida, Hiroatsu, Mori, Takehiko, Iwato, Koji, Eto, Tetsuya, Kawa, Keisei, Morita, Satoshi, and Morishima, Yasuo

Published
2013
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43. Allogeneic hematopoietic cell transplantation efficacy in patients with Philadelphia chromosome-positive acute myeloid leukemia in complete remission

Author

Mizuno, Shohei, primary, Yanada, Masamitsu, additional, Kawamura, Koji, additional, Masuko, Masayoshi, additional, Uchida, Naoyuki, additional, Ozawa, Yukiyasu, additional, Iwato, Koji, additional, Ohashi, Kazuteru, additional, Ikegame, Kazuhiro, additional, Kim, Sung-Won, additional, Tanaka, Masatsugu, additional, Eto, Tetsuya, additional, Kanda, Yoshinobu, additional, Fukuda, Takahiro, additional, Atsuta, Yoshiko, additional, Yano, Shingo, additional, and Takami, Akiyoshi, additional

Published
2020
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44. HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR

Author

Sakai, Kazuya, primary, Kuwana, Masataka, primary, Tanaka, Hidenori, primary, Hosomichi, Kazuyoshi, primary, Hasegawa, Atsushi, primary, Uyama, Hiroki, primary, Nishio, Kenji, primary, Omae, Takashi, primary, Hishizawa, Masakatsu, primary, Matsui, Masashi, primary, Iwato, Koji, primary, Okamoto, Akinao, primary, Okuhiro, Kazuki, primary, Yamashita, Yukiko, primary, Itoh, Masataka, primary, Kumekawa, Hanae, primary, Takezako, Naoki, primary, Kawano, Noriaki, primary, Matsukawa, Toshihiro, primary, Sano, Haruna, primary, Ohshiro, Kazuiku, primary, Hayashi, Kunio, primary, Ueda, Yasunori, primary, Mushino, Toshiki, primary, Ogawa, Yoshiyuki, primary, Yamada, Yuji, primary, Murata, Mitsuru, primary, and Matsumoto, Masanori, primary

Published
2020
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46. Using a machine learning algorithm to predict acute graft-versus-host disease following allogeneic transplantation

Author

10826564, 30378624, Arai, Yasuyuki, Kondo, Tadakazu, Fuse, Kyoko, Shibasaki, Yasuhiko, Masuko, Masayoshi, Sugita, Junichi, Teshima, Takanori, Uchida, Naoyuki, Fukuda, Takahiro, Kakihana, Kazuhiko, Ozawa, Yukiyasu, Eto, Tetsuya, Tanaka, Masatsugu, Ikegame, Kazuhiro, Mori, Takehiko, Iwato, Koji, Ichinohe, Tatsuo, Kanda, Yoshinobu, Atsuta, Yoshiko, 10826564, 30378624, Arai, Yasuyuki, Kondo, Tadakazu, Fuse, Kyoko, Shibasaki, Yasuhiko, Masuko, Masayoshi, Sugita, Junichi, Teshima, Takanori, Uchida, Naoyuki, Fukuda, Takahiro, Kakihana, Kazuhiko, Ozawa, Yukiyasu, Eto, Tetsuya, Tanaka, Masatsugu, Ikegame, Kazuhiro, Mori, Takehiko, Iwato, Koji, Ichinohe, Tatsuo, Kanda, Yoshinobu, and Atsuta, Yoshiko

Abstract

Acute graft-versus-host disease (aGVHD) is 1 of the critical complications that often occurs following allogeneic hematopoietic stem cell transplantation (HSCT). Thus far, various types of prediction scores have been created using statistical calculations. The primary objective of this study was to establish and validate the machine learning–dependent index for predicting aGVHD. This was a retrospective cohort study that involved analyzing databases of adult HSCT patients in Japan. The alternating decision tree (ADTree) machine learning algorithm was applied to develop models using the training cohort (70%). The ADTree algorithm was confirmed using the hazard model on data from the validation cohort (30%). Data from 26 695 HSCT patients transplanted from allogeneic donors between 1992 and 2016 were included in this study. The cumulative incidence of aGVHD was 42.8%. Of >40 variables considered, 15 were adapted into a model for aGVHD prediction. The model was tested in the validation cohort, and the incidence of aGVHD was clearly stratified according to the categorized ADTree scores; the cumulative incidence of aGVHD was 29.0% for low risk and 58.7% for high risk (hazard ratio, 2.57). Predicting scores for aGVHD also demonstrated the link between the risk of development aGVHD and overall survival after HSCT. The machine learning algorithms produced clinically reasonable and robust risk stratification scores. The relatively high reproducibility and low impacts from the interactions among the variables indicate that the ADTree algorithm, along with the other data-mining approaches, may provide tools for establishing risk score.

Published
2019

47. Allogeneic hematopoietic stem cell transplantation from family members other than HLA-identical siblings over the last decade (1991-2000)

Author

Kanda, Yoshinobu, Chiba, Shigeru, Hirai, Hisamaru, Sakamaki, Hisashi, Iseki, Tohru, Kodera, Yoshihisa, Karasuno, Takahiro, Okamoto, Shinichiro, Hirabayashi, Noriyuki, Iwato, Koji, Maruta, Atsuo, Fujimori, Yoshihiro, Furukawa, Tatsuo, Mineishi, Shin, Matsuo, Keitaro, Hamajima, Nobuyuki, and Imamura, Masahiro

Published
2003
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49. Outcomes of patients who developed subsequent solid cancer after hematopoietic cell transplantation

Author

Inamoto, Yoshihiro, Matsuda, Tomohiro, Tabuchi, Ken, Kurosawa, Saiko, Nakasone, Hideki, Nishimori, Hisakazu, Yamasaki, Satoshi, Doki, Noriko, Iwato, Koji, Mori, Takehiko, Takahashi, Satoshi, Yabe, Hiromasa, Kohno, Akio, Nakamae, Hirohisa, Sakura, Toru, Hashimoto, Hisako, Sugita, Junichi, Ago, Hiroatsu, Fukuda, Takahiro, Ichinohe, Tatsuo, Atsuta, Yoshiko, Yamashita, Takuya, and Japan Society for Hematopoietic Cell Transplantation Late Effects and Quality of Life Working Group

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Population, Hematopoietic stem cell transplantation, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, hemic and lymphatic diseases, Cancer screening, Medicine, Humans, Registries, education, Child, Survival rate, Aged, Aged, 80 and over, education.field_of_study, Transplantation, Hematopoietic cell, business.industry, Allogeneic Cells, Age Factors, Hematopoietic Stem Cell Transplantation, Cancer, Neoplasms, Second Primary, Hematology, Middle Aged, medicine.disease, Clinical trial, Survival Rate, surgical procedures, operative, 030220 oncology & carcinogenesis, Child, Preschool, Female, business, 030215 immunology
Abstract

To characterize the outcomes of patients who developed a particular subsequent solid cancer after hematopoietic cell transplantation (HCT), age at cancer diagnosis, survival, and causes of death were compared with the respective primary cancer in the general population, using data from the national HCT registry and population-based cancer registries in Japan. Among 31 867 patients who underwent a first HCT between 1990 and 2013 and had progression-free survival at 1 year, 713 patients developed subsequent solid cancer. The median age at subsequent solid cancer diagnosis was 55 years, which was significantly younger than the 67 years for primary cancer patients in the general population (P < .001). The overall survival probability was 60% at 3 years after diagnosis of subsequent solid cancer and differed according to cancer type. Development of most solid cancers was associated with an increased risk of subsequent mortality after HCT. Subsequent solid cancers accounted for 76% of causes of death. Overall survival probabilities adjusted for age, sex, and year of diagnosis were lower in the HCT population than in the general population for colon, bone/soft tissue, and central nervous system cancers and did not differ statistically for other cancers. In conclusion, most subsequent solid cancers occurred at younger ages than primary cancers, emphasizing the need for cancer screening at younger ages. Subsequent solid cancers showed similar or worse survival compared with primary cancers. Biological and genetic differences between primary and subsequent solid cancers remain to be determined.

Published
2018

50. Allogeneic Stem Cell Transplantation in Patients with Philadelphia Chromosome-Positive Acute Myeloid Leukemia in Japan

Author

Mizuno, Shohei, primary, Yanada, Masamitsu, additional, Kawamura, Koji, additional, Yano, Shingo, additional, Masuko, Masayoshi, additional, Uchida, Naoyuki, additional, Ozawa, Yukiyasu, additional, Iwato, Koji, additional, Ohashi, Kazuteru, additional, Ikegame, Kazuhiro, additional, Kim, Sung-Won, additional, Tanaka, Masatsugu, additional, Eto, Tetsuya, additional, Kanda, Yoshinobu, additional, Fukuda, Takahiro, additional, Atsuta, Yoshiko, additional, and Takami, Akiyoshi, additional

Published
2019
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