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Abstract: Transcriptional function of cyclin D1, whose deregulation is frequently observed in human cancers, has been suggested to contribute to cancer formation. In the present study, we show that cyclin D1 protein inhibits RUNX3 activity by directly binding to it and interfering with its interaction with p300 interaction in lung cancer cells. Cyclin D1 inhibits p300-dependent RUNX3 acetylation and negatively regulates cyclin-dependent kinase (cdk) inhibitor p21 expression. These transcriptional effects of cyclin D1 do not require cdk4/6 kinase activation. We propose that cyclin D1 provides a transcriptional switch that allows the tumor suppressor activity of RUNX3 to be repressed in cancer cells. Since RUNX3 plays tumor suppressive roles in a wide range of cancers, a non-canonical cyclin D1 function may be critical for neoplastic transformation of the epithelial cells in which RUNX3 regulates proliferation. [ABSTRACT FROM AUTHOR]

Reported herein is a 57-year-old man infected by Sparganum mansoni, a kind of tapeworm, showing a solitary nodule of the middle lobe of the right lung. Because a transbronchial biopsy could not diagnose the nodule, a right middle lobectomy was performed on suspicion of malignant tumor. The lesion was diagnosed as sparganosis by histological and immuno-serological examinations. Histological examination revealed granulomatous inflammation with neutrophil and eosinophil infiltration around the worm and interstitial pneumonia surrounding the nodule. Moreover, vasculitis with foreign body giant cell was seen around the lesion. To the authors' knowledge this is the second case of sparganosis limited in the lung, and the current report presents the first detailed histological description of a pulmonary sparganosis case. [ABSTRACT FROM AUTHOR]

The article focuses on the study which aims to test the credibility of high-resolution CT scanning in detecting small bronchioloalveolar carcinoma or atypical adenomatous hyperplasia that appears as a ground-glass opacity (GGO). To test, impalpable GGO lesions are marked and resected under C-arm fluoroscopy. The results reveal that the use of fluoroscopy to cut sections from resected specimens after preoperative marking with lipiodol was useful for making pathologic sections of impalpable GGOs.

The article examines the microscopic-sized microthymoma that were found in 196 patients with myasthenia gravis (MG) who had undergone thymectomy or thymothymomectomy. In the study conducted, the authors concluded that microthymoma might exist in thymus of patients with MG and even in patients who have no thymoma indicated by computed tomography. Other significant information and medical literatures relative to the matter are presented.