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Your search keyword '"Iwase, M."' showing total 1,368 results
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1,368 results on '"Iwase, M."'

14. Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism

Author

Kawarasaki S, Sawazaki H, Iijima H, Ng SP, Kwon J, Mohri S, Iwase M, Jheng HF, Takahashi H, Nomura W, Inoue K, Kawada T, and Goto T

Subjects
sglt2 inhibitor, obesity, dosing method, Specialties of internal medicine, RC581-951
Abstract

Satoko Kawarasaki,1 Honami Sawazaki,1 Hiroaki Iijima,2 Su-Ping Ng,1 Jungin Kwon,1 Shinsuke Mohri,1 Mari Iwase,1 Huei-Fen Jheng,1 Haruya Takahashi,1 Wataru Nomura,1,3 Kazuo Inoue,1,3 Teruo Kawada,1,3 Tsuyoshi Goto1,3 1Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011, Japan; 2Ikuyaku. Integrated Value Development Division, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan; 3Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8317, JapanCorrespondence: Tsuyoshi GotoLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011, JapanTel +81-774-38-3753Fax +81-774-38-3752Email goto.tsuyoshi.6x@kyoto-u.ac.jpPurpose: Sodium-glucose co-transporter-2 (SGLT2) inhibitors have various pleiotropic effects, including body weight reduction, and therefore have the potential to be used in various applications. However, such effects have not been fully investigated; thus, non-clinical studies using animal models are needed. In animal experiments, SGLT2 inhibitors are usually administered by oral or dietary methods. However, the detailed characteristics of these dosing methods, especially to induce their pleiotropic effects, have not been reported. Therefore, we compared the preventive effects of canagliflozin, an SGLT2 inhibitor, on body weight gain following oral gavage and dietary administration methods in a mouse model of diet-induced obesity.Methods: Canagliflozin was dosed by oral gavage or dietary administration for 9 weeks to 6-week-old C57BL/6N mice fed a high-fat diet, and parameters related to obesity were evaluated.Results: The suppression of body weight gain, fat mass, and hepatic lipid content was observed following both dosing methods, whereas the effect on body weight tended to be stronger in the dietary administration group. In adipose tissue, fatty acid synthase expression was significantly decreased in the dietary administration group, and its expression was significantly correlated with fat mass. However, the expression of genes related to fatty acid oxidation was unchanged, indicating that the preventive effect on body weight gain was mediated mainly through the suppression of lipid synthesis rather than the promotion of lipid oxidation.Conclusion: Canagliflozin prevented body weight gain through the suppression of lipid synthesis via both dosing methods, although there were some differences in the efficacy. The findings of our study can help to identify new mechanisms of action of SGLT2 inhibitors and potential applications.Keywords: SGLT2 inhibitor, obesity, dosing method

Published
2020

15. Scaling behavior of the crossover to short-stack regimes of Josephson vortex lattices in Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ stacks

Author

Kakeya, I., Kubo, Y., Kohri, M., Iwase, M., Yamamoto, T., and Kadowaki, K.

Subjects
Condensed Matter - Superconductivity
Abstract

We report the systematic investigations of the oscillation of the Josephson vortex (JV) flow resistance in Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ micro-fabricated junctions with various geometries and superconducting anisotropy parameters. As the applied magnetic field parallel to the $ab$-plane is increased, oscillation with a period corresponding to a $\phi_0/2$ par atomic Josephson junction changes to oscillation with a doubled period. This crossover is scaled by both the junction length and the anisotropy parameter, indicating that the bulk inductive coupling that favors the triangular JV lattice is replaced with the surface deformation energy as the dominant interaction for a JV lattice. These results suggest that the in-phase square JV lattice is pronounced at a higher magnetic field in a smaller and more anisotropic sample., Comment: 4 pages, 3 figures

Published
2009
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16. Josephson lattice structure in mesoscopic intrinsic Josephson junctions by means of flux-flow resistance in Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$

Author

Kakeya, I., Iwase, M., Yamazaki, T., Yamamoto, T., and Kadowaki, K.

Subjects
Condensed Matter - Superconductivity
Abstract

Dynamical nature of the Josephson vortex (JV) system in Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ (Bi2212) has been investigated in the presence of the c-axis current with magnetic field alignments very close to the $ab$-plane. As a function of magnetic fields, the c-axis JV flux flow resistance oscillates periodically in accordance with the proposed JV triangular structure. We observe that this oscillating period becomes doubled above a certain field, indicating the structure transition from triangle to square structure. This transition field becomes lower in junctions with smaller width perpendicular to the external field. We interpret that this phenomena as the effect of the edge deformation of the JV lattice due to surface current of intrinsic Josephson junctions as pointed by Koshelev., Comment: 4 pages, 3 figure

Published
2005

18. 359P Overall survival of palbociclib (PAL) + endocrine therapy (ET) in Japanese patients with hormone receptor-positive (HR+)/ human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) in the 1st line (1L) or 2nd line (2L) setting: A multicenter observational study

Author

Nakayama, T., Nagai, S.E., Hattori, M., Yoshinami, T., Masuda, H., Okamura, T., Watanabe, K-I., Tsuneizumi, M., Takabatake, D., Harao, M., Yasojima, H., Oshiro, C., Iwase, M., Yamaguchi, M., Sangai, T., Sasada, S., Ishida, T., Futamura, M., Kosaka, N., and Masuda, N.

Published
2024
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