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1. Current management and future perspectives of covert hepatic encephalopathy in Japan: a nationwide survey

Author

Miwa, Takao, Tsuruoka, Mio, Ueda, Hajime, Abe, Tamami, Inada, Hiroki, Yukawa-Muto, Yoshimi, Ohara, Masatsugu, Arai, Taeang, Tamai, Yasuyuki, Isoda, Hiroshi, Tadokoro, Tomoko, Hanai, Tatsunori, Ito, Takanori, Tamaki, Nobuharu, Sakamaki, Akira, Aoki, Yoshihiko, Tada, Fujimasa, Yoshio, Sachiyo, Takahashi, Hirokazu, Morishita, Asahiro, Ishikawa, Tsuyoshi, Inoue, Jun, Suda, Goki, Ogawa, Chikara, Atsukawa, Masanori, Hiraoka, Atsushi, Kuroda, Hidekatsu, Namisaki, Tadashi, Honda, Takashi, Kawaguchi, Takumi, Tanaka, Yasuhito, Terai, Shuji, Ikegami, Tadashi, Yoshiji, Hitoshi, Iwasa, Motoh, and Shimizu, Masahito

Published
2025
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3. ALBI score predicts morphological changes in esophageal varices following direct-acting antiviral-induced sustained virological response in patients with liver cirrhosis

Author

Atsukawa, Masanori, Tsubota, Akihito, Kondo, Chisa, Toyoda, Hidenori, Takaguchi, Koichi, Nakamuta, Makoto, Watanabe, Tsunamasa, Morishita, Asahiro, Tani, Joji, Okubo, Hironao, Hiraoka, Atsushi, Nozaki, Akito, Chuma, Makoto, Kawata, Kazuhito, Uojima, Haruki, Ogawa, Chikara, Asano, Toru, Mikami, Shigeru, Kato, Keizo, Matsuura, Kentaro, Ikegami, Tadashi, Ishikawa, Toru, Tsuji, Kunihiko, Tada, Toshifumi, Tsutsui, Akemi, Senoh, Tomonori, Kitamura, Michika, Okubo, Tomomi, Arai, Taeang, Kohjima, Motoyuki, Morita, Kiyoshi, Akahane, Takehiro, Nishikawa, Hiroki, Iwasa, Motoh, Tanaka, Yasuhito, and Iwakiri, Katsuhiko

Published
2024
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5. Methylated SEPT9 assay-based liquid biopsy as a biomarker in molecular targeted agent-treated hepatocellular carcinoma

Author

Saeki, Issei, Suehiro, Yutaka, Yamauchi, Yurika, Hoshida, Tomomi, Tanabe, Norikazu, Oono, Takashi, Kawamoto, Daiki, Nishimura, Tatsuro, Matsumoto, Toshihiko, Ishikawa, Tsuyoshi, Shimokawa, Mototsugu, Tamori, Akihiro, Kawada, Norifumi, Tamai, Yasuyuki, Iwasa, Motoh, Nakagawa, Hayato, Nagano, Hiroaki, Takami, Taro, and Yamasaki, Takahiro

Published
2023
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6. Risk factors for portopulmonary hypertension in patients with cirrhosis: a prospective, multicenter study

Author

Atsukawa, Masanori, Tsubota, Akihito, Kondo, Chisa, Koyano, Kaori-Shioda, Ishikawa, Toru, Toyoda, Hidenori, Takaguchi, Koichi, Watanabe, Tsunamasa, Matsuura, Kentaro, Ogawa, Chikara, Hiraoka, Atsushi, Okubo, Hironao, Tateyama, Masakuni, Uojima, Haruki, Nozaki, Akito, Chuma, Makoto, Kato, Keizo, Mikami, Shigeru, Tani, Joji, Morishita, Asahiro, Kawata, Kazuhito, Tada, Toshifumi, Furuichi, Yoshihiro, Okubo, Tomomi, Kawano, Tadamichi, Arai, Taeang, Kawabe, Naoto, Kawamura, Naohiro, Ikegami, Tadashi, Nakamuta, Makoto, Shigefuku, Ryuta, Iwasa, Motoh, Tanaka, Yasuhito, Hatano, Masaru, and Iwakiri, Katsuhiko

Published
2023
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7. Novel mutation of transferrin receptor 2 causing hereditary hemochromatosis type 3 in a Japanese patient.

Author

Tamai, Yasuyuki, Hosotani, Masami, Shigefuku, Ryuta, Tsuboi, Junya, Iwasa, Motoh, Okugawa, Yoshinaga, and Nakagawa, Hayato

Subjects
MEDICAL genetics, TRANSFERRIN receptors, JOINT pain, GENETIC testing, JOINTS (Anatomy)
Abstract

Hereditary hemochromatosis (HH) is recognized as a progressive iron‐storage disorder, and leading to severe organ impairments, including liver cirrhosis. Hereditary hemochromatosis type 3 arises from mutations in the transferrin receptor 2 (TFR2) gene. However, HH type 3 is rare in Asia, and information regarding genetic mutations and associated phenotypes remains limited. Here, we reported the case of a Japanese patient with HH type 3, with a novel homozygous mutation of the TFR2 gene. A 69‐year‐old woman presented to our hospital with hand joint pain and was referred due to liver impairment. Viral hepatitis and autoimmune liver diseases were ruled out. However, the transferrin saturation was 92.2%, and the serum ferritin level was 1611.8 ng/mL. Additionally, abdominal computed tomography showed diffuse increased density of the liver parenchyma. Abdominal magnetic resonance imaging also suggested iron deposition. There is no history of prior treatments involving blood transfusions or iron agents. Her parents were involved in a consanguineous marriage, prompting genetic testing. She had a homozygous novel mutation, c.1337G>A (p.G446E), in the TFR2 gene. Serum hepcidin‐25 level was decreased to 2.9 ng/mL. According to the American Society of Medical Genetics and Genomics guideline, the mutation was classified as likely pathogenic, leading to the diagnosis of HH type 3. Following phlebotomy, her arthritis resolved, and serum transaminase levels were normalized. This case marks the first demonstration of homozygous mutation, c.1337G>A (p.G446E), in the TFR2 gene in patients with HH type 3. [ABSTRACT FROM AUTHOR]

Published
2025
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12. Prognostic Significance of Psoas Muscle Index in Unresectable Hepatocellular Carcinoma: Comparative Analysis of Lenvatinib and Atezolizumab Plus Bevacizumab.

Author

Shigefuku, Ryuta, Iwasa, Motoh, Tanaka, Hideaki, Tsukimoto, Mone, Tamai, Yasuyuki, Fujiwara, Naoto, Yoshikawa, Kyoko, Tameda, Masahiko, Ogura, Suguru, and Nakagawa, Hayato

Subjects
*PSOAS muscles, *END of treatment, *OVERALL survival, *DRUG therapy, *HEPATOCELLULAR carcinoma
Abstract

Background and Aims: Skeletal muscle loss has been identified as a prognostic factor in patients with unresectable hepatocellular carcinoma (uHCC) undergoing treatment with lenvatinib (LEN). While atezolizumab plus bevacizumab (ATZ-BEV) is recommended as first-line therapy for uHCC, the impact of skeletal muscle loss in these patients remains unclear. Methods: We enrolled 97 patients treated with either LEN or ATZ-BEV as their first-line therapy and divided them into two groups based on the presence or absence of a low psoas muscle index (low PMI) before treatment. We compared patient characteristics and overall survival (OS) between the groups. Additionally, we investigated the transition of the PMI during drug therapy, specifically before treatment, at the initial evaluation, and after the end of treatment. Results: Seventy percent of patients in the LEN group and seventy-one percent in the ATZ-BEV group had a low PMI. Multivariate analysis across all patients revealed a low PMI (hazard ratio [HR] 3.25, p = 0.0004) as a prognostic factor for OS. The PMI decreased more in the LEN group compared to the ATZ-BEV group. In the Barcelona Clinic Liver Cancer—C group, the OS of ATZ-BEV therapy was significantly better than that of LEN therapy when a low PMI was present (p = 0.046). Conclusions: A low PMI emerges as a significant prognostic factor in uHCC patients undergoing drug therapy, not only in LEN therapy but also in ATZ-BEV therapy. Additionally, ATZ-BEV therapy may be more favorable for sarcopenic patients with advanced HCC stages. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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17. Serum Zinc-α2-glycoprotein Levels Are Associated with the Hepatorenal Function and Predict the Survival in Cases of Chronic Liver Disease

Author

Shigefuku, Ryuta, primary, Iwasa, Motoh, additional, Eguchi, Akiko, additional, Tempaku, Mina, additional, Tamai, Yasuyuki, additional, Fujiwara, Naoto, additional, Sugimoto, Ryosuke, additional, Tanaka, Hideaki, additional, Sugimoto, Kazushi, additional, Kobayashi, Yoshinao, additional, and Nakagawa, Hayato, additional

Published
2024
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20. Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity

Author

Kobayashi, Yoshinao, primary, Eguchi, Akiko, additional, Imami, Koshi, additional, Tempaku, Mina, additional, Izuoka, Kiyora, additional, Takase, Takafumi, additional, Kainuma, Keigo, additional, Nagao, Mizuho, additional, Furuta, Noriko, additional, Iwasa, Motoh, additional, Nakagawa, Hayato, additional, Fujisawa, Takao, additional, and Togashi, Kenji, additional

Published
2023
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22. Elevated extracellular particle concentration in plasma predicts in-hospital mortality after severe trauma.

Author

Becker, Nils, Franz, Niklas, Eguchi, Akiko, Wagner, Alessa, Sturm, Ramona, Rinderknecht, Helen, Kobayashi, Yoshinao, Iwasa, Motoh, Weber, Birte, Marzi, Ingo, and Relja, Borna

Subjects
HOSPITAL mortality, ERYTHROCYTES, BLOOD platelets, LACTATES, RECEIVER operating characteristic curves, EXTRACELLULAR vesicles
Abstract

Background: Extracellular particles (EPs), particularly extracellular vesicles, play a crucial role in regulating various pathological mechanisms, including immune dysregulations post-trauma. Their distinctive expression of cell-specific markers and regulatory cargo such as cytokines or micro-ribonucleic acid suggests their potential as early biomarkers for organ-specific damage and for identifying patients at risk for complications and mortality. Given the critical need for reliable and easily assessable makers to identify at-risk patients and guide therapeutic decisions, we evaluated the early diagnostic value of circulating EPs regarding outcomes in severely injured multiple-trauma patients. Methods: Plasma samples were collected from 133 severely injured trauma patients (Injury Severity Score (ISS) ≥16) immediately upon arrival at the emergency department (ED). Patients were categorized into survivors and non-survivors. Injury characteristics and outcomes related to sepsis, pneumonia, or early (<1 day after admission) and late mortality were assessed. Circulating EPs, cytokine profiles, and blood counts of platelets and leukocytes were determined. Receiver operating characteristic analyses were conducted. Results: Despite no significant differences in injury pattern or severity, non-survivors exhibited significantly elevated counts of circulating EPs compared to survivors. The optimal cut-off for EPs <200 nm indicating non-survivors was 17380/μl plasma, with a sensitivity of 77% and a specificity of 61% in predicting in hospital mortality. Later non-survivors received significantly higher numbers of units of packed red blood cells [8.54 ± 5.45 vs. 1.29 ± 0.36 units], had higher serum lactate [38.00 ± 7.51 vs. 26.98 ± 1.58 mg/dL], significantly lower platelet counts [181.30 ± 18.06 vs. 213.60 ± 5.85 *10³/μL] and lower heart rates [74.50 ± 4.93 vs. 90.18 ± 2.06 beats/minute] upon arrival at the ED compared to survivors. Conclusion: Our results demonstrate the high diagnostic potential of elevated concentrations of circulating EPs <200 nm for identifying patients at risk of mortality after severe trauma. This parameter shows comparable sensitivity to established clinical predictors. Early evaluation of EPs concentration could complement assessment markers in guiding early therapeutic decisions. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Hepatocellular Carcinoma Pseudoprogression Involving the Main Portal Vein, Right Ventricular Invasion, and Exacerbation of Lung Metastases in a Patient on Atezolizumab Plus Bevacizumab

Author

Shigefuku, Ryuta, primary, Yoshikawa, Kyoko, additional, Tsukimoto, Mone, additional, Owa, Hirono, additional, Tamai, Yasuyuki, additional, Tameda, Masahiko, additional, Ogura, Suguru, additional, Sugimoto, Ryosuke, additional, Tanaka, Hideaki, additional, Eguchi, Akiko, additional, Sugimoto, Kazushi, additional, Hasegawa, Hiroshi, additional, Iwasa, Motoh, additional, and Nakagawa, Hayato, additional

Published
2023
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28. Branched-Chain Amino Acids Prevent Hepatocarcinogenesis and Prolong Survival of Patients With Cirrhosis

Author

Kawaguchi, Takumi, Shiraishi, Koichi, Ito, Toshifumi, Suzuki, Kazutomo, Koreeda, Chizu, Ohtake, Takaaki, Iwasa, Motoh, Tokumoto, Yoshio, Endo, Ryujin, Kawamura, Nao–hiro, Shiraki, Makoto, Habu, Daiki, Tsuruta, Satoru, Miwa, Yoshiyuki, Kawaguchi, Atsushi, Kakuma, Tatsuyuki, Sakai, Hironori, Kawada, Norifumi, Hanai, Tatsunori, Takahashi, Shin–ichi, Kato, Akinobu, Onji, Morikazu, Takei, Yoshiyuki, Kohgo, Yutaka, Seki, Toshihito, Tamano, Masaya, Katayama, Kazuhiro, Mine, Tetsuya, Sata, Michio, Moriwaki, Hisataka, and Suzuki, Kazuyuki

Published
2014
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31. Risk factors for portopulmonary hypertension in patients with cirrhosis: a prospective, multicenter study

Author

Atsukawa, Masanori, primary, Tsubota, Akihito, additional, Kondo, Chisa, additional, Koyano, Kaori-Shioda, additional, Ishikawa, Toru, additional, Toyoda, Hidenori, additional, Takaguchi, Koichi, additional, Watanabe, Tsunamasa, additional, Matsuura, Kentaro, additional, Ogawa, Chikara, additional, Hiraoka, Atsushi, additional, Okubo, Hironao, additional, Tateyama, Masakuni, additional, Uojima, Haruki, additional, Nozaki, Akito, additional, Chuma, Makoto, additional, Kato, Keizo, additional, Mikami, Shigeru, additional, Tani, Joji, additional, Morishita, Asahiro, additional, Kawata, Kazuhito, additional, Tada, Toshifumi, additional, Furuichi, Yoshihiro, additional, Okubo, Tomomi, additional, Kawano, Tadamichi, additional, Arai, Taeang, additional, Kawabe, Naoto, additional, Kawamura, Naohiro, additional, Ikegami, Tadashi, additional, Nakamuta, Makoto, additional, Shigefuku, Ryuta, additional, Iwasa, Motoh, additional, Tanaka, Yasuhito, additional, Hatano, Masaru, additional, and Iwakiri, Katsuhiko, additional

Published
2022
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33. Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Author

Tamai, Yasuyuki, primary, Eguchi, Akiko, primary, Shigefuku, Ryuta, additional, Kitamura, Hiroshi, additional, Tempaku, Mina, additional, Sugimoto, Ryosuke, additional, Kobayashi, Yoshinao, additional, Iwasa, Motoh, additional, Takei, Yoshiyuki, additional, and Nakagawa, Hayato, additional

Published
2022
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34. Complement complex 1 subunit q‐mediated hepatic stellate cell activation with connective tissue growth factor elevation is a prognostic factor for survival in rat and human chronic liver diseases

Author

Eguchi, Akiko, primary, Iwasa, Motoh, additional, Sugimoto, Ryosuke, additional, Tempaku, Mina, additional, Yoshikawa, Kyoko, additional, Yoshizawa, Naohiko, additional, Povero, Davide, additional, Sugimoto, Kazushi, additional, Hasegawa, Hiroshi, additional, Takei, Yoshiyuki, additional, and Nakagawa, Hayato, additional

Published
2022
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35. Author response: Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Author

Tamai, Yasuyuki, primary, Eguchi, Akiko, primary, Shigefuku, Ryuta, additional, Kitamura, Hiroshi, additional, Tempaku, Mina, additional, Sugimoto, Ryosuke, additional, Kobayashi, Yoshinao, additional, Iwasa, Motoh, additional, Takei, Yoshiyuki, additional, and Nakagawa, Hayato, additional

Published
2022
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36. The prognostic potential of fragmented CK18 serum levels in HCC patients reflecting disease progression and overall hepatocyte damage

Author

Eguchi, Akiko, primary, Iwasa, Motoh, additional, Tamai, Yasuyuki, additional, Yamada, Minori, additional, Okuno, Koji, additional, Shigefuku, Ryuta, additional, Yoshikawa, Kyoko, additional, Tempaku, Mina, additional, Sakaguchi, Koji, additional, Tanaka, Hideaki, additional, Sugimoto, Kazushi, additional, Kobayashi, Yoshinao, additional, Yamaguchi, Tetsuji, additional, and Nakagawa, Hayato, additional

Published
2022
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41. A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis

Author

Eguchi, Akiko, primary, Iwasa, Motoh, additional, Yamada, Minori, additional, Tamai, Yasuyuki, additional, Shigefuku, Ryuta, additional, Hasegawa, Hiroshi, additional, Hirokawa, Yoshifumi, additional, Hayashi, Akinobu, additional, Okuno, Koji, additional, Matsushita, Yuki, additional, Nakatsuka, Takuma, additional, Enooku, Kenichiro, additional, Sakaguchi, Koji, additional, Kobayashi, Yoshinao, additional, Yamaguchi, Tetsuji, additional, Watanabe, Masatoshi, additional, Takei, Yoshiyuki, additional, and Nakagawa, Hayato, additional

Published
2022
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42. Additional file 3 of Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal hemodynamics and liver function

Author

Shigefuku, Ryuta, Takahashi, Hideaki, Watanabe, Tsunamasa, Hattori, Nobuhiro, Ikeda, Hiroki, Matsunaga, Kotaro, Ehira, Takuya, Suzuki, Tatsuya, Matsumoto, Nobuyuki, Okuse, Chiaki, Iwasa, Motoh, Nakagawa, Hayato, Itoh, Fumio, and Suzuki, Michihiro

Abstract

Additional file 3. Supplementary Figure 3. Xe-CT protocol The wash-in and wash-out periods were of 4 min. The entire liver was CT-scanned at 1-min intervals at four levels, including the porta hepatis (nine scans in total, including the baseline scan).

Published
2022
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43. Additional file 4 of Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal hemodynamics and liver function

Author

Shigefuku, Ryuta, Takahashi, Hideaki, Watanabe, Tsunamasa, Hattori, Nobuhiro, Ikeda, Hiroki, Matsunaga, Kotaro, Ehira, Takuya, Suzuki, Tatsuya, Matsumoto, Nobuyuki, Okuse, Chiaki, Iwasa, Motoh, Nakagawa, Hayato, Itoh, Fumio, and Suzuki, Michihiro

Abstract

Additional file 4 Supplementary Figure 4. Endoscopic findings of esophageal varices before and after EIS (A) Before EIS (F2 esophageal varices), (B) After EIS (White cord). EIS has been performed until the varices were eradicated.

Published
2022
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44. Additional file 2 of Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal hemodynamics and liver function

Author

Shigefuku, Ryuta, Takahashi, Hideaki, Watanabe, Tsunamasa, Hattori, Nobuhiro, Ikeda, Hiroki, Matsunaga, Kotaro, Ehira, Takuya, Suzuki, Tatsuya, Matsumoto, Nobuyuki, Okuse, Chiaki, Iwasa, Motoh, Nakagawa, Hayato, Itoh, Fumio, and Suzuki, Michihiro

Abstract

Additional file 2. Supplementary Figure 2. Xe-CT theory By applying the Fick principle, a single blood supply model (inflow: arterial only, outflow: venous) can be fitted to a dual blood supply model (inflow: arterial and portal venous) to separately determine HATBF (ml/100 ml/min) and PVTBF (ml/100 ml/min).

Published
2022
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45. Additional file 1 of Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal hemodynamics and liver function

Author

Shigefuku, Ryuta, Takahashi, Hideaki, Watanabe, Tsunamasa, Hattori, Nobuhiro, Ikeda, Hiroki, Matsunaga, Kotaro, Ehira, Takuya, Suzuki, Tatsuya, Matsumoto, Nobuyuki, Okuse, Chiaki, Iwasa, Motoh, Nakagawa, Hayato, Itoh, Fumio, and Suzuki, Michihiro

Abstract

Additional file 1. Supplementary Figure 1. Definition for portosystemic shunts The para-esophageal veins (Para-V) (arrows) denote azygos veins and enter the superior vena cava. The para-umbilical vein connects from the portal vein to systemic circulation. The gastrorenal shunt (arrow head) connects from the left gastric vein or portogastric, short gastric veins to the left renal vein.

Published
2022
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46. SAT-101 Morphological changes in esophageal varices in patients with HCVrelated cirrhosis who achieved sustained virological response by direct-acting antivirals

Author

Nagao, Chikako, Atsukawa, Masanori, Kawano, Tadamichi, Arai, Taeang, Tsubota, Akihito, Kondo, Chisa, Okubo, Tomomi, Toyoda, Hidenori, Takaguchi, Koichi, Nakamura, Makoto, Watanabe, Tsunamasa, Morishita, Asahiro, Okubo, Hironao, Hiraoka, Atsushi, Nozaki, Akito, Kawata, Kazuhito, Uojima, Haruki, Ogawa, Chikara, Ishikawa, Toru, Nishikawa, Hiroki, Iwasa, Motoh, Tanaka, Yasuhito, and Iwakiri, Katsuhiko

Published
2024
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50. Extracellular vesicles in fatty liver disease and steatohepatitis: Role as biomarkers and therapeutic targets.

Author

Eguchi, Akiko, Iwasa, Motoh, and Nakagawa, Hayato

Subjects
*EXTRACELLULAR vesicles, *ADIPOSE tissue diseases, *FATTY liver, *NON-alcoholic fatty liver disease, *DISEASE risk factors, *DRUG target, *LIVER diseases
Abstract

Non‐alcoholic fatty liver disease (NAFLD) and alcohol‐associated liver disease (ALD) are characterized by lipid deposition in hepatocytes in the absence or presence of excessive alcohol consumption, respectively, ranging from simple steatosis to non‐alcoholic steatohepatitis (NASH) or alcoholic hepatitis (AH) and from mild fibrosis to cirrhosis. Fatty liver disease and steatohepatitis similarly occur in individuals who have both metabolic syndrome and excessive alcohol intake; therefore, the single overarching term metabolic associated fatty liver disease (MAFLD) has been proposed to better reflect these risk factors and the continuity of disease progression. Extracellular vesicles (EVs) are membrane‐bound endogenous nanoparticles released into the extracellular space by a majority of cell types. Liver disease‐related EVs contain a variety of cellular cargo and are internalized into target cells resulting in the transfer of bioinformation reflecting the state of the donor cell to the recipient. Furthermore, EV composition can be used to identify the degree and type of liver disease, suggesting that EV composition may be a useful biomarker. With regard to MAFLD, the presence of metabolic risk factors, such as insulin resistance, will be indicated by adipose tissue‐derived EVs and with that comes the potential to use as a clinical monitor of overall metabolic status. However, the inhibition of specific EV composition may be difficult to implement as a real‐world therapeutic approach. Current global evidence shows that mesenchymal stem cell (MSCs)‐derived EVs (MSC‐EVs) play an important role in regulating the immune response, which has spawned a clinical trial to treat liver disease. [ABSTRACT FROM AUTHOR]

Published
2023
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