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6. Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, Matsueda, Kazuhiro, Yoshioka, Masao, Miyahara, Koji, Sakaguchi, Chihiro, Nishimura, Mamoru, Nagahara, Teruya, Mannami, Tomohiko, Takenaka, Ryuta, Oka, Shohei, Inoue, Masafumi, Takimoto, Hidetaka, Inaba, Tomoki, Kobayashi, Sayo, Toyokawa, Tatsuya, Tsugeno, Hirofumi, Suzuki, Seiyuu, Sawada, Sachiko, Tanaka, Shouichi, Tsuzuki, Takao, and Okada, Hiroyuki

Published
2023
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12. Recent updates on treatment options for primary follicular lymphoma of the gastrointestinal tract.

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, and Otsuka, Motoyuki

Abstract

Background: Primary gastrointestinal follicular lymphoma is a subtype of follicular lymphoma that originates directly from the gastrointestinal tract. Pathologically, it exhibits substantial similarities with the secondary gastrointestinal involvement observed in nodal follicular lymphoma. However, primary gastrointestinal follicular lymphoma presents clinically distinct features, necessitating divergent considerations in treatment selection compared with nodal follicular lymphoma. Areas covered: This narrative review focused on recent articles (2018–2023) regarding the long-term prognosis and treatment options for gastrointestinal follicular lymphoma. In addition, a brief overview of gastrointestinal follicular lymphomas is provided. Expert opinion: Patients with primary gastrointestinal follicular lymphoma often present with a low tumor burden. Lymphoma lesions typically remain asymptomatic for several years or may undergo spontaneous regression without immediate treatment. Therefore, a 'watch and wait' approach is justified. Conversely, when large tumor masses are identified in the gastrointestinal tract, the potential for tumor bleeding or intestinal obstruction requires timely therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Endoscopic and Histological Gastritis in University Students with Helicobacter pylori Infection

Author

Okanoue, Shotaro, primary, Sakae, Hiroyuki, additional, Yokota, Kenji, additional, Tanaka, Takehiro, additional, Obayashi, Yuka, additional, Abe, Makoto, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Yanai, Hiroyuki, additional, and Okada, Hiroyuki, additional

Published
2024
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16. Hepatic Stellate Cells in Liver Tumor

Author

Shiraha, Hidenori, Iwamuro, Masaya, Okada, Hiroyuki, Crusio, Wim E., Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, and Birbrair, Alexander, editor

Published
2020
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20. Endoscopic and clinical features of gastric emphysema

Author

Iwamuro, Masaya, primary, Takenaka, Ryuta, additional, Toyokawa, Tatsuya, additional, Kita, Masahide, additional, Tsuzuki, Takao, additional, Yoshioka, Masao, additional, Gotoda, Tatsuhiro, additional, Okanoue, Shotaro, additional, Matsubara, Minoru, additional, Sakaguchi, Chihiro, additional, and Otsuka, Motoyuki, additional

Published
2023
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21. MO66-2 The use of ramucirumab before nivolumab may improve survival for unresectable advanced or recurrent gastric cancer

Author

Hirata, Shoichiro, primary, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Inoo, Shoko, additional, Kuraoka, Sakiko, additional, Matsueda, Katsunori, additional, Okanoue, Shotaro, additional, Satomi, Takuya, additional, Hamada, Kenta, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, and Kawahara, Yoshiro, additional

Published
2023
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22. Optimal Bowel Preparation Method to Visualize the Distal Ileum via Small Bowel Capsule Endoscopy

Author

Kametaka, Daisuke, primary, Ito, Mamoru, additional, Kawano, Seiji, additional, Ishiyama, Shuhei, additional, Fujiwara, Akiko, additional, Nasu, Junichirou, additional, Yoshioka, Masao, additional, Shiode, Junji, additional, Yamamoto, Kazuhide, additional, Iwamuro, Masaya, additional, Kawahara, Yoshiro, additional, Okada, Hiroyuki, additional, and Otsuka, Motoyuki, additional

Published
2023
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24. Lesion size, elevated morphology, and non or closed-type atrophy are predictive factors for gastric adenocarcinoma of the fundic gland type rather than oxyntic gland adenoma

Author

Iwamuro, Masaya, Kusumoto, Chiaki, Nakagawa, Masahiro, Matsueda, Kazuhiro, Kobayashi, Sayo, Yoshioka, Masao, Inaba, Tomoki, Toyokawa, Tatsuya, Sakaguchi, Chihiro, Tanaka, Shouichi, Tanaka, Takehiro, and Okada, Hiroyuki

Subjects
oxyntic gland adenoma, Gastric adenocarcinoma of the fundic gland type (GA-FG), Oncology, gastric neoplasms, submucosal invasion, Gastroenterology
Abstract

Background: An oxyntic gland neoplasm confined to the mucosal layer (T1a) is classified as an oxyntic gland adenoma, whereas that with submucosal invasion (T1b) is defined as gastric adenocarcinoma of the fundic gland type (GA-FG). Methods: To reveal the differences in clinical features between them, we retrospectively investigated 136 patients with 150 oxyntic gland adenoma and GA-FG lesions. Results: The univariate analysis revealed that the mean size (GA-FG vs. oxyntic gland adenoma, 7.7±5.4 vs. 5.5±3.1 mm), the prevalence of elevated morphology (79.1% vs. 51.8%), black pigmentation within the lesion (23.9% vs. 9.6%), and non or closed-type atrophy (81.2% vs. 65.1%) were different between the two groups. A multivariate logistic regression analysis revealed that ≥5 mm lesion size (odds ratio, 2.96; 95% confidence interval: 1.21–7.23), elevated morphology (odds ratio, 2.40; 95% confidence interval: 1.06–5.45), and no or closed-type atrophy (odds ratio, 2.49; 95% confidence interval: 1.07–5.80) were factors in distinguishing GA-FG from oxyntic gland adenoma. When oxyntic gland neoplasms with no or one feature were judged as oxyntic gland adenomas and those with two or three features were judged as GA-FG, the sensitivity and specificity were 85.1% and 43.4% for GA-FG, respectively. Conclusions: We identified three possible distinctive features of GA-FG compared to oxyntic gland adenoma: lesion size ≥5 mm, elevated morphology, and no or closed-type atrophy.

Published
2023

27. Results of the interim analysis of a prospective, multicenter, observational study of small subepithelial lesions in the stomach.

Author

Iwamuro, Masaya, Mitsuhashi, Toshiharu, Inaba, Tomoki, Matsueda, Kazuhiro, Nagahara, Teruya, Takeuchi, Yoji, Doyama, Hisashi, Mizuno, Masakatsu, Yada, Tomoyuki, Kawai, Yoshinari, Nakamura, Jun, Matsubara, Minoru, Nebiki, Hiroko, Niimi, Keiko, Toyokawa, Tatsuya, Takenaka, Ryuta, Takeda, Sho, Tanaka, Shouichi, Nishimura, Mamoru, and Tsuzuki, Takao

Subjects
*SCIENTIFIC observation, *STOMACH, *NATURAL history, *GASTROINTESTINAL stromal tumors, TUMOR surgery
Abstract

Objectives: Long‐term outcomes of gastric subepithelial lesions have not been elucidated. To reveal the natural history, we initiated a prospective, 10‐year follow‐up of patients with small (≤20 mm) gastric subepithelial lesions in September 2014. Here, we report the results of an interim analysis of a prospective observational study. Methods: In total, 567 patients with 610 lesions were prospectively registered between September 2014 and August 2016. The location, size, morphology, and number of subepithelial lesions were recorded on a web‐based case report form. This study has been conducted as an Academic Committee Working Group of the Japan Gastroenterological Endoscopy Society. Results: The endoscopic follow‐up period was 4.60 ± 1.73 years (mean ± standard deviation), and survival data were investigated for 5.28 ± 1.68 years. This interim analysis revealed that the estimated cumulative incidence of a size increase ≥5 mm, after accounting for patients' death and resection of the tumor as competing risk events, was 4.5% at 5 years. In addition, the estimated cumulative incidence of lesion size increase ≥5 mm or resection of lesions was 7.9% at 5 years, and that of size increase ≥10 mm or resection of lesions was 4.5% at 5 years. Conclusion: These results indicate that approximately one in 13 patients with small (≤20 mm) gastric subepithelial lesions may require resection or further investigation for increased tumor size (≥5 mm) within 5 years. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure.

Author

Kikuchi, Tatsuya, Kono, Yoshiyasu, Nakagawa, Koji, Okada, Hiroyuki, Miyamoto, Masakazu, Takaya, Yoichi, Hirata, Shoichiro, Inoo, Shoko, Kuraoka, Sakiko, Okanoue, Shotaro, Matsueda, Katsunori, Satomi, Takuya, Hamada, Kenta, Iwamuro, Masaya, Kawano, Seiji, and Kawahara, Yoshiro

Subjects
LEFT atrial appendage closure, GASTROINTESTINAL hemorrhage
Abstract

Background and Aim: Anticoagulant users with nonvalvular atrial fibrillation (NVAF) sometimes suffer from gastrointestinal bleeding (GIB) and have difficulty continuing the medication. Left atrial appendage closure (LAAC) has been developed for such situations. We aimed to clarify the clinical significance of a history of GIB in comparison to other factors in patients who had undergone LAAC. Methods: From October 2019 to September 2023, patients with NVAF who underwent LAAC at our hospital were enrolled. We investigated the percentage of patients with a history of GIB who underwent LAAC and compared the incidence of post‐LAAC bleeding in these patients compared to those with other factors. Results: A total of 45 patients were included. There were 19 patients (42%) with a history of GIB who underwent LAAC. In a Kaplan–Meier analysis, the cumulative incidence of bleeding complications after LAAC was significantly higher in patients with a history of GIB in comparison to patients with other factors. There were eight cases of post‐LAAC bleeding in total, and seven cases had GIB. Conclusions: We need to recognize that GIB is a significant complication in patients who undergo LAAC. The management of GIB by gastroenterologists is essential to the success of LAAC. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Scattered Tiny Whitish Protrusions in the Stomach Are a Clue to the Diagnosis of Autoimmune Gastritis

Author

Iwamuro, Masaya, Tanaka, Takehiro, Hamada, Kenta, Kono, Yoshiyasu, Kanzaki, Hiromitsu, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Subjects
small white protrusions, mucosal lesions, esophagogastroduodenoscopy, scattered lesions, autoimmune gastritis
Abstract

Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis.

Published
2023

31. Association of screening tool scores with overall survival in older patients with unresectable gastrointestinal or biliary pancreatic cancer: A retrospective study

Author

Inoo, Shoko, Kono, Yoshiyasu, Kanzaki, Hiromitsu, Horiguchi, Shigeru, Kato, Hironari, Yamasaki, Yasushi, Hirata, Shoichiro, Kuraoka, Sakiko, Matsueda, Katsunori, Okanoue, Shotaro, Satomi, Takuya, Hamada, Kenta, Iwamuro, Masaya, Kawano, Seiji, Kawahara, Yoshiro, Okada, Hiroyuki, and Otsuka, Motoyuki

Published
2024
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35. Results of the interim analysis of a prospective, multicenter, observational study of small subepithelial lesions in the stomach

Author

Iwamuro, Masaya, primary, Mitsuhashi, Toshiharu, additional, Inaba, Tomoki, additional, Matsueda, Kazuhiro, additional, Nagahara, Teruya, additional, Takeuchi, Yoji, additional, Doyama, Hisashi, additional, Mizuno, Masakatsu, additional, Yada, Tomoyuki, additional, Kawai, Yoshinari, additional, Nakamura, Jun, additional, Matsubara, Minoru, additional, Nebiki, Hiroko, additional, Niimi, Keiko, additional, Toyokawa, Tatsuya, additional, Takenaka, Ryuta, additional, Takeda, Sho, additional, Tanaka, Shouichi, additional, Nishimura, Mamoru, additional, Tsuzuki, Takao, additional, Akahoshi, Kazuya, additional, Furuta, Takahisa, additional, Haruma, Ken, additional, and Okada, Hiroyuki, additional

Published
2023
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38. Degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia

Author

Abe, Makoto, additional, Kawahara, Yoshiro, additional, Obayashi, Yuka, additional, Baba, Yuki, additional, Hamada, Kenta, additional, Sakae, Hiroyuki, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitu, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Makino, Takuma, additional, Noda, Yohei, additional, Marunaka, Hidenori, additional, and Okada, Hiroyuki, additional

Published
2023
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47. Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

Author

Kono, Yoshiyasu, Matsubara, Minoru, Toyokawa, Tatsuya, Takenaka, Ryuta, Suzuki, Seiyu, Nasu, Junichirou, Yoshioka, Masao, Nakagawa, Masahiro, Mizuno, Motowo, Sakae, Hiroyuki, Abe, Makoto, Gotoda, Tatsuhiro, Miura, Ko, Kanzaki, Hiromitsu, Iwamuro, Masaya, Hori, Keisuke, Tsuzuki, Takao, Kita, Masahide, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Published
2017
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48. Four types of duodenal white lesions (follicular lymphoma, lymphoid hyperplasia, lymphangiectasia, and lymphangioma) : A case report

Author

Iwamuro, Masaya, Tanaka, Takehiro, and Okada, Hiroyuki

Subjects
十二指腸濾胞性リンパ腫（duodenal-type follicular lymphoma）, リンパ管腫（lymphangioma）, リンパ濾胞過形成（lymphoid hyperplasia）, リンパ管拡張（lymphangiectasia）
Abstract

A 70-year-old Japanese man underwent esophagogastroduodenoscopy that revealed multiple whitish duodenal granules. The histopathological analysis of the biopsied specimen led to the diagnosis of duodenal-type follicular lymphoma. The lesion showed spontaneous improvement ; however, 14 months later a few small whitish granules were observed by esophagogastroduodenoscopy. Observation under magnification revealed slightly elevated opaque white spots and whitish granular protrusions of roughly the same size that were uniformly distributed in the duodenal bulb. The duodenal bulb lesions were histopathologically diagnosed as lymphoid hyperplasia. The patient also exhibited lymphangiectasia (which presented as scattered white spots) and lymphangioma (which presented as a soft submucosal tumor with white spots on the surface) in the second portion of the duodenum. This patient presented with four white lesions in the duodenum : duodenal-type follicular lymphoma, lymphoid hyperplasia, lymphangiectasia, and lymphangioma. Careful endoscopic evaluation enabled a prompt diagnosis in this case.

Published
2021

50. Zinc Acetate Dihydrate Tablet-associated Gastric Lesions

Author

Iwamuro, Masaya, Tanaka, Takehiro, Kuraoka, Sakiko, Hamada, Kenta, Abe, Makoto, Kono, Yoshiyasu, Kanzaki, Hiromitsu, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Subjects
gastric erosion, gastric ulcer, zinc acetate dihydrate, esophagogastroduodenoscopy, Internal Medicine, Stomach Diseases, Zinc Acetate, Humans, General Medicine, Ulcer, Retrospective Studies, Tablets
Abstract

Objective This study aimed to determine the prevalence and endoscopic features of zinc acetate dihydrate tablet-associated gastric lesions. Methods We retrospectively examined the endoscopic features of 47 patients taking zinc acetate dihydrate tablets who underwent esophagogastroduodenoscopy. Results Gastric mucosal alterations, including redness, erosions, ulcers, and adhesion of the white coat, were observed in 29 of 47 patients (61.7%). Among patients with gastric lesions (group A), there was a sig-nificantly higher percentage of symptomatic patients in comparison to patients without lesions (group B) (65.5% vs. 22.2%; p Conclusion Gastric lesions were observed in 29 of 47 patients who were taking zinc acetate dihydrate tab-lets. The most common endoscopic findings were mucosal redness (93.1%), erosions (90.0%), adhesion of the white coat (86.2%), and ulcers (31.0%). Although the exact pathogenesis is uncertain, we believe that un-derstanding the unique manifestations of this gastric lesion will help physicians manage adverse events in pa-tients taking zinc acetate dihydrate tablets.

Published
2022

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