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3. Population pharmacokinetics and pharmacodynamic target attainment analysis of cefazolin using total and unbound serum concentration in patients with prostatectomy or nephrectomy

Author

Komatsu, Toshiaki, primary, Kawai, Yuka, additional, Takayama, Yoko, additional, Akamada, Yuto, additional, Kusume, Eri, additional, Ikeda, Masaomi, additional, Tsumura, Hideyasu, additional, Ishii, Daisuke, additional, Iwamura, Masatsugu, additional, Okamoto, Hirotsugu, additional, Hanaki, Hideaki, additional, and Otori, Katsuya, additional

Published
2024
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5. Predictive Value of the Prostate-Specific Antigen Doubling Time for the Effectiveness of Metastasis-Directed Radiotherapy in Patients with Oligometastases after Radical Treatment for Non-metastatic Prostate Cancer: A Single Institution Retrospective Study

Author

Koguchi, Dai, primary, Tabata, Ken-ichi, additional, Hirano, Shuhei, additional, Shimura, Soichiro, additional, Satoh, Takefumi, additional, Ikeda, Masaomi, additional, Matsumoto, Kazumasa, additional, Niibe, Yuzuru, additional, and Iwamura, Masatsugu, additional

Published
2024
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6. Real-world data on the comprehensive genetic profiling test for Japanese patients with metastatic castration-resistant prostate cancer

Author

Koguchi, Dai, primary, Tsumura, Hideyasu, additional, Tabata, Ken-ichi, additional, Shimura, Soichiro, additional, Satoh, Takefumi, additional, Ikeda, Masaomi, additional, Watanabe, Akinori, additional, Yoshida, Tsutomu, additional, Sasaki, Jiichiro, additional, Matsumoto, Kazumasa, additional, and Iwamura, Masatsugu, additional

Published
2024
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21. Efficacy and safety of single-dose ivermectin in mild-to-moderate COVID-19: the double-blind, randomized, placebo-controlled CORVETTE-01 trial

Author

Wada, Tatsuhiko, Hibino, Makoto, Aono, Hiromi, Kyoda, Shunsuke, Iwadate, Yosuke, Shishido, Eri, Ikeda, Keisuke, Kinoshita, Nana, Matsuda, Yasuki, Otani, Sakiko, Kameda, Ryo, Matoba, Kenta, Nonaka, Miwa, Maeda, Mika, Kumagai, Yuji, Ako, Junya, Shichiri, Masayoshi, Naoki, Katsuhiko, Katagiri, Masato, Takaso, Masashi, Iwamura, Masatsugu, Katayama, Kazuhiko, Miyatsuka, Takeshi, Orihashi, Yasushi, and Yamaoka, Kunihiro

Subjects
General Medicine
Published
2023
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22. Efficacy of Intravesical Instillation Therapy with Low-Dose Tokyo-172 Bacillus Calmette-Guérin to Prevent Recurrence of Non-Muscle-Invasive Bladder Cancer and Treat Carcinoma in situ: A Multi-Institutional Retrospective Study

Author

Tachibana, Takashi, primary, Ikeda, Masaomi, additional, Shimura, Soichiro, additional, Amano, Noriyuki, additional, Murakami, Yasukiyo, additional, Yamada, Yasufumi, additional, Koguchi, Dai, additional, Maeyama, Ryota, additional, Kawamura, Mizuho, additional, Sakata, Yusuke, additional, Hagiwara, Masahiro, additional, Matsumoto, Kazumasa, additional, and Iwamura, Masatsugu, additional

Published
2023
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23. Additional file 2 of Development and validation of a survival nomogram and calculator for male patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate and/or enzalutamide

Author

Kawahara, Takashi, Saigusa, Yusuke, Yoneyama, Shuko, Kato, Masashi, Kojima, Ippei, Yamada, Hiroshi, Kamihira, Osamu, Tabata, Kenichi, Tsumura, Hideyasu, Iwamura, Masatsugu, Makiyama, Kazuhide, Uemura, Hiroji, and Miyoshi, Yasuhide

Abstract

Additional file 2: Supplementary Fig. 2. Kaplan–Meier curve of overall survival in metastatic castration-resistant prostate cancer patients treated with abiraterone first or enzalutamide first.

Published
2023
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24. Additional file 1 of Development and validation of a survival nomogram and calculator for male patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate and/or enzalutamide

Author

Kawahara, Takashi, Saigusa, Yusuke, Yoneyama, Shuko, Kato, Masashi, Kojima, Ippei, Yamada, Hiroshi, Kamihira, Osamu, Tabata, Kenichi, Tsumura, Hideyasu, Iwamura, Masatsugu, Makiyama, Kazuhide, Uemura, Hiroji, and Miyoshi, Yasuhide

Abstract

Additional file 1: Supplementary Fig. 1. Kaplan–Meier curve of overall survival in metastatic castration-resistant prostate cancer patients treated with abiraterone and/or enzalutamide.

Published
2023
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26. Patients with Non-Muscle-Invasive Bladder Cancer Previously Treated with Nephroureterectomy Have a High Risk of Recurrence after Bacillus Calmette-Guérin Intravesical Instillation Therapy.

Author

Maeyama, Ryota, Ikeda, Masaomi, Shimura, Soichiro, Amano, Noriyuki, Murakami, Yasukiyo, Yamada, Yasufumi, Koguchi, Dai, Tachibana, Takashi, Kawamura, Mizuho, Sakata, Yusuke, Hagiwara, Masahiro, Matsumoto, Kazumasa, and Iwamura, Masatsugu

Subjects
BLADDER cancer, NON-muscle invasive bladder cancer, BCG immunotherapy, INTRAVESICAL administration, TRANSURETHRAL resection of bladder, PROPORTIONAL hazards models
Abstract

Background: There is a high incidence of intravesical recurrence after transurethral resection of bladder tumor for non-muscle-invasive bladder cancer (NMIBC). Intravesical instillation of bacillus Calmette-Guérin (BCG) is widely used to prevent recurrence and progression. There are two types of NMIBC: primary NMIBC and subsequent NMIBC after radical nephroureterectomy (RNU). We compared the clinical outcomes of BCG intravesical instillation therapy between the two types of NMIBC. Patients and Methods: This study included a total of 357 patients, who received BCG intravesical instillation therapy to prevent recurrence of NMIBC (pTa/pT1) between 1991 and 2019. Among them, 34 patients had subsequent NMIBC after RNU, and the remaining 323 patients had primary NMIBC. This retrospective study analyzed 68 patients extracted by propensity score matching. Survival curves were estimated using the Kaplan-Meier method, and independent prognostic factors for survival were examined by the Cox proportional hazards model. Results: The 3-year recurrence-free survival (RFS) rates in patients with primary NMIBC and subsequent NMIBC after RNU were 70.7% and 54.8%, respectively (p = 0.036). However, there were no significant differences between the two groups in progression-free survival and cancer-specific survival. Multivariate analysis of RFS showed that only a previous history of upper tract urothelial carcinoma was an independent prognostic and predictive factor. Conclusion: Patients with subsequent NMIBC after RNU treated with BCG intravesical instillation therapy have a higher risk of recurrence than those with primary NMIBC. Thus, stringent follow-up is necessary for patients with subsequent NMIBC after RNU. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Pre-Vaccination Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in Workers at Three Japanese Hospitals

Author

Takayama, Yoko, primary, Komatsu, Toshiaki, additional, Wada, Tatsuhiko, additional, Nihonyanagi, Shin, additional, Hoshiyama, Takayuki, additional, Moriya, Tatsumi, additional, Shimamura, Shizue, additional, Kajigaya, Naoko, additional, Naito, Masanori, additional, Takeuchi, Osamu, additional, Bando, Yuki, additional, Watanabe, Masahiko, additional, Iwamura, Masatsugu, additional, and Hanaki, Hideaki, additional

Published
2022
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28. The development and validation of a nomogram and calculator for survival among men treated with abiraterone acetate and/or enzalutamide for metastatic castration-resistant prostate cancer

Author

Kawahara, Takashi, primary, Saigusa, Yusuke, additional, Yoneyama, Shuko, additional, Kato, Masashi, additional, Kojima, Ippei, additional, Yamada, Hiroshi, additional, Kamihira, Osamu, additional, Tabata, Kenichi, additional, Tsumura, Hideyasu, additional, Iwamura, Masatsugu, additional, Makiyama, Kazuhide, additional, uemura, Hiroji, additional, and Miyoshi, Yasuhide, additional

Published
2022
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29. Gemcitabine–Paclitaxel Chemotherapy for Patients with Advanced Urothelial Cancer Refractory to Cisplatin-Based Chemotherapy: Predictive Role of PGK1 for Treatment Response to Cytotoxic Chemotherapy

Author

Koguchi, Dai, primary, Matsumoto, Kazumasa, additional, Ikeda, Masaomi, additional, Shimizu, Yuriko, additional, Nakamura, Marie, additional, Shiono, Yutaka, additional, Katsumata, Hiroki, additional, Sato, Yuichi, additional, and Iwamura, Masatsugu, additional

Published
2022
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32. Noninferior oncological outcomes in adults aged 80 years or older compared with younger patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma

Author

Yamada, Yasufumi, primary, Ikeda, Masaomi, additional, Hirayama, Takahiro, additional, Murakami, Yasukiyo, additional, Koguchi, Dai, additional, Matsuda, Daisuke, additional, Okuno, Norihiko, additional, Taoka, Yoshinori, additional, Utsunomiya, Takuji, additional, Irie, Akira, additional, Matsumoto, Kazumasa, additional, and Iwamura, Masatsugu, additional

Published
2022
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33. Real‐world treatment patterns and oncological outcomes in early relapse and refractory disease after bacillus Calmette‐Guérin failure in non‐muscle‐invasive bladder cancer

Author

Murakami, Yasukiyo, primary, Matsumoto, Kazumasa, additional, Miyake, Makito, additional, Amano, Noriyuki, additional, Shimura, Soichiro, additional, Nishimura, Nobutaka, additional, Iida, Kota, additional, Matsushita, Yuto, additional, Abe, Takashige, additional, Yamada, Takeshi, additional, Uemura, Motohide, additional, Matsui, Yoshiyuki, additional, Taoka, Rikiya, additional, Kojima, Takahiro, additional, Kobayashi, Takashi, additional, Nishiyama, Naotaka, additional, Kitamura, Hiroshi, additional, Nishiyama, Hiroyuki, additional, Fujimoto, Kiyohide, additional, and Iwamura, Masatsugu, additional

Published
2022
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39. Noninferior oncological outcomes in adults aged 80 years or older compared with younger patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma.

Author

Yamada, Yasufumi, Ikeda, Masaomi, Hirayama, Takahiro, Murakami, Yasukiyo, Koguchi, Dai, Matsuda, Daisuke, Okuno, Norihiko, Taoka, Yoshinori, Utsunomiya, Takuji, Irie, Akira, Matsumoto, Kazumasa, and Iwamura, Masatsugu

Subjects
OCTOGENARIANS, TRANSITIONAL cell carcinoma, OLDER patients
Abstract

Aim: Radical nephroureterectomy (RNU) is the gold standard treatment for upper tract urothelial carcinoma (UTUC), but the usefulness of this surgery for older patients is rarely discussed. The prognosis following RNU for patients ≥80 years old remains controversial. We retrospectively investigated the prognosis of UTUC in patients ≥80 years old who underwent RNU. Methods: Between January 1990 and December 2015, 451 patients with UTUC underwent RNU at six hospitals affiliated with Kitasato University (Kanagawa, Japan), eight patients who underwent neoadjuvant chemotherapy and two patients with metastases before surgery were excluded. Patients were divided into three groups according to their age at the time of RNU: ≤64 years (n = 135), 65–79 years (n = 254), and ≥80 years (n = 52). Recurrence‐free survival (RFS), cancer‐specific survival (CSS), and overall survival (OS) curves were estimated using Kaplan–Meier analysis for all patients and each pT stage. Independent prognostic factors for survival were examined via multivariate analysis. Results: RFS and CSS did not significantly differ between the three groups, but OS was significantly poorer in patients ≥80 years old. Stratification by pT stage (≤pT1, ≥pT2, and ≥pT3) yielded the same results. In the multivariate analysis for OS, an age of ≥80 years was a significant independent risk factor (hazard ratio: 3.01, p =.01), but RFS and CSS did not significantly differ. Conclusion: Oncological outcomes showed the same anticancer effects in patients ≥80 years old who underwent RNU for UTUC compared with those of younger patients. Our study suggests that surgical treatment is a beneficial option for older patients who can tolerate radical surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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42. A multi‐institutional retrospective study of open versus laparoscopic nephroureterectomy focused on the intravesical recurrence

Author

Shimura, Soichiro, primary, Matsumoto, Kazumasa, additional, Ikeda, Masaomi, additional, Moroo, Shigenori, additional, Koguchi, Dai, additional, Taoka, Yoshinori, additional, Hirayama, Takahiro, additional, Murakami, Yasukiyo, additional, Utsunomiya, Takuji, additional, Matsuda, Daisuke, additional, Okuno, Norihiko, additional, Irie, Akira, additional, and Iwamura, Masatsugu, additional

Published
2022
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43. Patients with Non-Muscle Invasive Bladder Cancer Previously Treated with Nephroureterectomy Have a High Risk of Recurrence after Bacillus Calmette-Guérin Intravesical Instillation Therapy

Author

Maeyama, Ryota, primary, Ikeda, Masaomi, additional, Shimura, Soichiro, additional, Amano, Noriyuki, additional, Murakami, Yasukiyo, additional, Yamada, Yasufumi, additional, Koguchi, Dai, additional, Tachibana, Takashi, additional, Kawamura, Mizuho, additional, Sakata, Yusuke, additional, Hagiwara, Masahiro, additional, Matsumoto, Kazumasa, additional, and Iwamura, Masatsugu, additional

Published
2022
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44. A multi‐institutional retrospective study of open versus laparoscopic nephroureterectomy focused on the intravesical recurrence.

Author

Shimura, Soichiro, Matsumoto, Kazumasa, Ikeda, Masaomi, Moroo, Shigenori, Koguchi, Dai, Taoka, Yoshinori, Hirayama, Takahiro, Murakami, Yasukiyo, Utsunomiya, Takuji, Matsuda, Daisuke, Okuno, Norihiko, Irie, Akira, and Iwamura, Masatsugu

Subjects
PREOPERATIVE risk factors, LAPAROSCOPIC surgery, BLADDER cancer, UNIVARIATE analysis, TRANSITIONAL cell carcinoma, INTRAVESICAL administration, MULTIVARIATE analysis, RECTAL surgery
Abstract

Aim: Intravesical recurrence (IVR) after nephroureterectomy for upper tract urothelial carcinoma (UTUC) is relatively frequent, occurring in about 30–50% of patients. The aim of this study was to investigate the differences of the prognosis and IVR between open and laparoscopic surgery and to elucidate the risk factor of IVR. Patients and methods: We retrospectively analyzed data from 403 patients with UTUC treated with laparoscopic or open nephroureterectomy at six affiliated hospitals between 1990 and 2015. The clinicopathological factors of each group were examined using Kaplan–Meier plots, and univariate and multivariate analyses. Results: There was no difference in recurrence and cancer‐specific mortality between open and laparoscopic surgery in univariate and multivariate analyses. There was no significant difference in IVR rate between the laparoscopic and open groups (p =.22). Among the patients with IVR, 84% of patients relapsed within 2 years. Univariate analysis of IVR showed a significant increase in patients with low‐grade (p =.03, HR = 1.64) or low‐stage urothelial carcinoma (pT1 or lower, p =.006, HR = 1.77) with no lymph node involvement (p =.002, HR = 10.3) or lymphovascular invasion (p =.009, HR = 1.79). Surgical modality was not an independent factor. In multivariate analysis, there was no independent predictive factor for IVR. Conclusions: There was no difference in recurrence, cancer‐specific mortality, and IVR between open and laparoscopic surgery. On the other hand, our results suggested that the low malignant potential tumor may be a risk factor for IVR. This finding provides insight into IVR, which may help with the development of personalized prevention and treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Impact of Salvage Cytotoxic Chemotherapy on Prognosis in Patients with Recurrence After Radical Cystectomy: A Multi-Institutional Retrospective Study

Author

Koguchi, Dai, primary, Matsumoto, Kazumasa, additional, Ikeda, Masaomi, additional, Taoka, Yoshinori, additional, Hirayama, Takahiro, additional, Murakami, Yasukiyo, additional, Utsunomiya, Takuji, additional, Matsuda, Daisuke, additional, Okuno, Norihiko, additional, Irie, Akira, additional, and Iwamura, Masatsugu, additional

Published
2022
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49. A Case of Retroperitoneal Mature Teratoma Successfully Treated by Laparoscopic Adrenalectomy

Author

Hirano, Shuhei, Fujita, Tetsuo, Nomura, Megumi, Mochizuki, Kohei, Nishi, Morihiro, Tsumura, Hideyasu, Matsumoto, Kazumasa, Yoshida, Kazunari, and Iwamura, Masatsugu

Subjects
Retroperitonial tumor, Mature teratoma, Laparoscopic adrenalectomy, 494.9
Abstract

We report a case of retroperitoneal mature teratoma which was successfully treated by laparoscopic adrenalectomy. A 37-year-old woman complaining of right abdominal discomfort was referred to our hospital because computed tomography showed an adrenal tumor at another hospital. Magnetic resonance imaging showed a 10 cm adrenal tumor that consisted of fat with calcification. Endocrine examination showed no abnormal findings. Under the suspicion of myelolipoma, we performed laparoscopic right adrenalectomy. Histological diagnosis was mature teratoma. The patient had no recurrence at 5 years after surgery.

Published
2020

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