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5. SURG-01. DIFFERENTIATION OF GLIOBLASTOMA AND MALIGNANT MENINGIOMA FROM NORMAL BRAIN BY TISSUE STIFFNESS UTILIZING MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY

Author

Ezaki, Taketo, primary, Kisima, Kohki, additional, Shibao, Shunsuke, additional, Matsunaga, Takuya, additional, Pareira, Eriel Sandika, additional, Kitamura, Yohei, additional, Takahara, Kento, additional, Iwama, Takashi, additional, Sampetrean, Oltea, additional, Ohnishi, Kouhei, additional, Shimono, Tomoyuki, additional, and Sasaki, Hikaru, additional

Published
2023
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8. Clinical Effectiveness of Mirogabalin Besylate for Trigeminal Neuropathy after Skull Base Surgery: Illustrative Cases.

Author

Karatsu, Kosuke, Tamura, Ryota, Miyauchi, Tsubasa, Sogano, Junki, Hino, Utaro, Iwama, Takashi, and Toda, Masahiro

Subjects
SKULL base, SKULL surgery, POSTOPERATIVE pain treatment, POSTERIOR cranial fossa, NEUROPATHY, POSTHERPETIC neuralgia, TRIGEMINAL nerve diseases, ANALGESIA
Abstract

Background: Postoperative trigeminal neuropathy may be seen after surgery for middle and posterior cranial fossa lesions. Although neuropathic pain is a cause of reduced quality of life, global consensus on postoperative pain management is lacking. Mirogabalin besylate is a selective ligand for the α2δ subunit of voltage-gated calcium channels. Although mirogabalin has been used for patients with postherpetic neuralgia and painful diabetic peripheral neuropathy, few reports have assessed the effect on postsurgical neuropathy. In this report, we describe a clinical effectiveness of mirogabalin for trigeminal neuropathy after skull base surgery. Case description: Case 1: A 51-year-old female with right trigeminal schwannoma was operated on via the anterior transpetrosal approach. She had tingling and numb feelings in the right face postoperatively. Mirogabalin was orally administered after the operation. Her continuous facial numbness immediately improved. Case 2: A 55-year-old female with left middle fossa base meningioma extending into the infratemporal fossa was operated on via the infratemporal fossa approach. She had a tingling feeling in the left face postoperatively. Mirogabalin was orally administered for this symptom after the operation, which gradually improved. Conclusions: Mirogabalin may show significant pain relief for patients with trigeminal neuropathy after skull base surgery. Further studies using a larger number of patients are warranted to confirm these findings. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Materia Japan

Author

Kimura, Hideyuki, primary, Ono, Yoshihiko, additional, Nakajima, Katsumi, additional, Iwama, Takashi, additional, and Sakurai, Michitaka, additional

Published
2008
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