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1,465 results on '"Ivy, D"'

2. Two Heuristics for the Tree Poset Cover Problem

Author

Coronel, Willie N., Jr., Relucio, Joshua, Ordanel, Ivy D., Juayong, Richelle Ann B., Li, Kan, Editor-in-Chief, Li, Qingyong, Associate Editor, Fournier-Viger, Philippe, Series Editor, Hong, Wei-Chiang, Series Editor, Liang, Xun, Series Editor, Wang, Long, Series Editor, Xu, Xuesong, Series Editor, Caro, Jaime, editor, Hagihara, Shigeki, editor, Nishizaki, Shin-ya, editor, Numao, Masayuki, editor, and Suarez, Merlin, editor

Published
2024
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3. SOX17-Associated Pulmonary Hypertension in Children: A Distinct Developmental and Clinical Syndrome

Author

Mullen, Mary P., Ivy, D. Dunbar, Varghese, Nidhy P., Winant, Abbey J., Cortes-Santiago, Nahir, Vargas, Sara O., Porres, Diego, Maschietto, Nicola, Critser, Paul J., Hirsch, Russel, Avitabile, Catherine M., Hopper, Rachel K., Frank, Benjamin S., Coleman, Ryan D., Agrawal, Pankaj B., Madden, Jill A., Roberts, Amy E., Collins, Shane L., Raj, J. Usha, Austin, Eric D., Chung, Wendy K., and Abman, Steven H.

Published
2025
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11. Semi-invariants of Binary Forms and Sylvester's Theorem

Author

Chen, William Y. C. and Jia, Ivy D. D.

Subjects
Mathematics - Combinatorics, Mathematics - Representation Theory, 05A17, 05E10, 13A50
Abstract

We obtain a combinatorial formula related to the shear transformation for semi-invariants of binary forms, which implies the classical characterization of semi-invariants in terms of a differential operator. Then, we present a combinatorial proof of an identity of Hilbert, which leads to a relation of Cayley on semi-invariants. This identity plays a crucial role in the original proof of Sylvester's theorem on semi-invariants in connection with the Gaussian coefficients. Moreover, we show that the additivity lemma of Pak and Panova which yields the strict unimodality of the Gaussian coefficients for $n,k \geq 8$ can be deduced from the ring property of semi-invariants., Comment: 15 pages, 7 figures, to appear in the Ramanujan Journal, dedicated to Doron Zeilberger on the occasion of his seventieth birthday

Published
2020

12. Semi-invariants of Binary Forms Pertaining to a Unimodality Theorem of Reiner and Stanton

Author

Chen, William Y. C. and Jia, Ivy D. D.

Subjects
Mathematics - Combinatorics, Mathematics - Representation Theory, 05A17, 05E10, 13A50
Abstract

The symmetric difference of the $q$-binomial coefficients $F_{n,k}(q)={n+k\brack k}-q^{n}{n+k-2\brack k-2}$ was introduced by Reiner and Stanton. They proved that $F_{n,k}(q)$ is symmetric and unimodal for $k \geq 2$ and $n$ even by using the representation theory for Lie algebras. Based on Sylvester's proof of the unimodality of the Gaussian coefficients, as conjectured by Cayley, we find an interpretation of the unimodality of $F_{n,k}(q)$ in terms of semi-invariants. In the spirit of the strict unimodality of the Gaussian coefficients due to Pak and Panova, we prove the strict unimodality of the symmetric difference $G_{n,k,r}(q)={n+k\brack k}-q^{nr/2}{n+k-r\brack k-r}$, except for the two terms at both ends, where $n,r\geq8$, $k\geq r$ and at least one of $n$ and $r$ is even., Comment: 13 pages, to appear in a special issue of the International Journal of Mathematics dedicated to the memory of Professor S.S. Chern

Published
2020

15. Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR).

Author

Min, Jeff, Feng, Rui, Badesch, David, Berman-Rosenzweig, Erika, Burger, Charles, Chakinala, Murali, De Marco, Teresa, Feldman, Jeremy, Hemnes, Anna, Horn, Evelyn M, Lammi, Matthew R, Mathai, Stephen, McConnell, John W, Presberg, Kenneth, Robinson, Jeffrey, Sager, Jeffrey, Shlobin, Oksana, Simon, Marc, Thenappan, Thenappan, Ventetuolo, Corey, Al-Naamani, Nadine, Allen, Roblee, Bartolome, Sonja, Benza, Raymond, Bull, Todd, Cadaret, Linda, Eggert, Michael, Elwing, Jean, Fineman, Jeffrey, Foley, Raymond, Ford, H James, Frantz, Robert, Hirsch, Russel, Grinnan, James, Ivy, D Dunbar, Kawut, Steven, Kennedy, Jamie, Klinger, James, Leary, Peter, Mazimba, Sula, Ramani, Gautam, Raina, Amresh, Runo, James, Swisher, John, Ryan, John, Varghese, Nidhy, White, R James, Williamson, Timothy, Yung, Delphine, Zamanian, Roham, and Zwicke, Dianne

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Nutrition, Clinical Research, Transplantation, Lung, Prevention, Obesity, Cardiovascular, pulmonary arterial hypertension, obesity, quality of life, hospitalization, survival analysis, PHAR Investigators, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleObesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.ObjectivesTo assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.MethodsWe performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.Results767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p

Published
2021

28. Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems

Author

Prokopec, Stephenie D, Houlahan, Kathleen E, Sun, Ren X, Watson, John D, Yao, Cindy Q, Lee, Jamie, P’ng, Christine, Pang, Renee, Wu, Alexander H, Chong, Lauren C, Smith, Ashley B, Harding, Nicholas J, Moffat, Ivy D, Lindén, Jere, Lensu, Sanna, Okey, Allan B, Pohjanvirta, Raimo, and Boutros, Paul C

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Agent Orange & Dioxin, Genetics, Animals, Cell Line, Computational Biology, Environmental Pollutants, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Male, Mice, Polychlorinated Dibenzodioxins, Rats, Software, Transcriptome, Web Browser, TCDD, AHR, Microarray datasets, R, Information and Computing Sciences, Medical and Health Sciences, Bioinformatics, Biological sciences, Biomedical and clinical sciences
Abstract

Background2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of toxicity is highly dependent on the aryl hydrocarbon receptor (AHR). Binding of TCDD to the AHR leads to changes in transcription of numerous genes. Studies evaluating the transcriptional changes brought on by TCDD may provide valuable insight into the role of the AHR in human health and disease. We therefore compiled a collection of transcriptomic datasets that can be used to aid the scientific community in better understanding the transcriptional effects of ligand-activated AHR.ResultsSpecifically, we have created a datasets package - TCDD.Transcriptomics - for the R statistical environment, consisting of 63 unique experiments comprising 377 samples, including various combinations of 3 species (human derived cell lines, mouse and rat), 4 tissue types (liver, kidney, white adipose tissue and hypothalamus) and a wide range of TCDD exposure times and doses. These datasets have been fully standardized using consistent preprocessing and annotation packages (available as of September 14, 2015). To demonstrate the utility of this R package, a subset of "AHR-core" genes were evaluated across the included datasets. Ahrr, Nqo1 and members of the Cyp family were significantly induced following exposure to TCDD across the studies as expected while Aldh3a1 was induced specifically in rat liver. Inmt was altered only in liver tissue and primarily by rat-AHR.ConclusionsAnalysis of the "AHR-core" genes demonstrates a continued need for studies surrounding the impact of AHR-activity on the transcriptome; genes believed to be consistently regulated by ligand-activated AHR show surprisingly little overlap across species and tissues. Until now, a comprehensive assessment of the transcriptome across these studies was challenging due to differences in array platforms, processing methods and annotation versions. We believe that this package, which is freely available for download ( http://labs.oicr.on.ca/boutros-lab/tcdd-transcriptomics ) will prove to be a highly beneficial resource to the scientific community evaluating the effects of TCDD exposure as well as the variety of functions of the AHR.

Published
2017

34. Age-related differences in hemodynamics and functional status in pulmonary arterial hypertension: Baseline results from the Pulmonary Hypertension Association Registry

Author

Allen, Roblee, Badesch, David, Bakshi, Sahil, Bartolome, Sonja, Bull, TM, Burger, Charles D, Cadaret, Linda M, Chakinala, Murali, De Marco, Teresa, Duncan, Michael, Eggert, Michael, Elwing, Jean M., Feldman, Jeremy, Fineman, Jeff, Foley, Raymond J., Ford, Hubert James, Frantz, Robert P, Grinnan, Daniel, Hemnes, Anna R, Hirsch, Russel, Horn, Evelyn M, Ivy, D Dunbar, Kawut, Steven M, Klinger, James R, Lammi, Matthew R., Leary, Peter J, Mathai, Stephen C, Mazimba, Sula, McConnell, John W., Parikh, Kishan S, Presberg, Kenneth W, Raina, Amresh, Ramani, Gautam, Robinson, Jeffrey C, Rosenzweig, Erika B, Runo, James R, Ryan, John J, Sager, Jeffrey S, Shlobin, Oksana A, Simon, Marc A, Swisher, John W, Thenappan, Thenappan, Varghese, Nidhy P, Ventetuolo, Corey E, White, R. James, Williamson, Timothy, Yung, Delphine, Zamanian, Roham T, Zwicke, Dianne L, DesJardin, Jacqueline T., Kolaitis, Nicholas A., Kime, Noah, Kronmal, Richard A., Benza, Raymond L., Presberg, Kenneth W., Sager, Jeffrey S., and Shlobin, Oksana A.

Published
2020
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45. Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials

Author

Avitabile, Catherine M., primary, Krishnan, Usha S., additional, Yung, Delphine, additional, Handler, Stephanie S., additional, Varghese, Nidhy, additional, Bates, Angela, additional, Fineman, Jeff, additional, Sullivan, Rachel, additional, Friere, Grace, additional, Austin, Eric, additional, Mullen, Mary P., additional, Pereira, Carol, additional, Christensen, Eric J., additional, Yenokyan, Gayane, additional, Collaco, Joseph M., additional, Abman, Steven H., additional, Romer, Lew, additional, Dunbar Ivy, D., additional, and Rosenzweig, Erika B., additional

Published
2024
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46. Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity.

Author

Sun, Ren X, Chong, Lauren C, Simmons, Trent T, Houlahan, Kathleen E, Prokopec, Stephenie D, Watson, John D, Moffat, Ivy D, Lensu, Sanna, Lindén, Jere, P'ng, Christine, Okey, Allan B, Pohjanvirta, Raimo, and Boutros, Paul C

Subjects
Animals, Mice, Rats, Receptors, Aryl Hydrocarbon, Cluster Analysis, Gene Expression Profiling, Computational Biology, Signal Transduction, Organ Specificity, Species Specificity, Gene Expression Regulation, Protein Binding, Male, Transcriptome, Aryl hydrocarbon receptor, AHR endogenous ligands, Constitutive gene expression, TCDD-induced toxicity, Core-gene battery, Receptors, Aryl Hydrocarbon, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Bioinformatics
Abstract

BackgroundResearch on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic hydrocarbons. But the AHR also plays key roles in regulating pathways critical for development, and after decades of research the mechanisms underlying physiological regulation by the AHR remain poorly characterized. Previous studies identified several core genes that respond to xenobiotic AHR ligands across a broad range of species and tissues. However, only limited inferences have been made regarding its role in regulating constitutive gene activity, i.e. in the absence of exogenous ligands. To address this, we profiled transcriptomic variations between AHR-active and AHR-less-active animals in the absence of an exogenous agonist across five tissues, three of which came from rats (hypothalamus, white adipose and liver) and two of which came from mice (kidney and liver). Because AHR status alone has been shown sufficient to alter transcriptomic responses, we reason that by contrasting profiles amongst AHR-variant animals, we may elucidate effects of the AHR on constitutive mRNA abundances.ResultsWe found significantly more overlap in constitutive mRNA abundances amongst tissues within the same species than from tissues between species and identified 13 genes (Agt, Car3, Creg1, Ctsc, E2f6, Enpp1, Gatm, Gstm4, Kcnj8, Me1, Pdk1, Slc35a3, and Sqrdl) that are affected by AHR-status in four of five tissues. One gene, Creg1, was significantly up-regulated in all AHR-less-active animals. We also find greater overlap between tissues at the pathway level than at the gene level, suggesting coherency to the AHR signalling response within these processes. Analysis of regulatory motifs suggests that the AHR mostly mediates transcriptional regulation via direct binding to response elements.ConclusionsThese findings, though preliminary, present a platform for further evaluating the role of the AHR in regulation of constitutive mRNA levels and physiologic function.

Published
2014

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