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Your search keyword '"Iven, Heiko"' showing total 24 results
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24 results on '"Iven, Heiko"'

12. A novel molecular mechanism of action for azathioprine in IBD: 6-Thio-GTP induces apoptosis of lamina propria T cells via blockade of the GTPase Rac1

Author

Tiede, Imke, primary, Poppe, Daniela, additional, Strand, Susanne, additional, Strand, Dennis, additional, Wirtz, Stefan, additional, Becker, Christoph, additional, Blumberg, Richard, additional, Iven, Heiko, additional, Ahmadian, Reza Mohammad, additional, Galle, Peter R., additional, and Neurath, Markus F., additional

Published
2003
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23. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4[sup+]T lymphocytes.

Author

Tiede, Imke, Fritz, Gerhard, Strand, Susanne, Poppe, Daniela, Dvorsky, Radovan, Strand, Dennis, Lehr, Hans Anton, Wirtz, Stefan, Becker, Christoph, Atreya, Raja, Mudter, Jonas, Hildner, Kai, Bartsch, brigitte, Holtmann, Martin, Blumberg, Richard, Walczak, Henning, Iven, Heiko, Galle, Peter R., and Ahmadian, Mohammad Reza

Subjects
*IMMUNOSUPPRESSIVE agents, *T cells, *APOPTOSIS
Abstract

Focuses on a study which identified the role of the immunosuppresive agent azathioprine and its metabolites in the control of T cell apoptosis. methods; Results; Discussion.

Published
2003
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24. Cisapride may improve feeding tolerance of preterm infants: a randomized placebo-controlled trial.

Author

Kohl M, Wuerdemann I, Clemen J, Iven H, Katalinic A, and Moeller JC

Subjects
Birth Weight, Cisapride adverse effects, Electrocardiography, Female, Gastrointestinal Agents adverse effects, Gastrointestinal Transit, Humans, Infant Formula, Infant, Newborn, Male, Milk, Human, Placebos, Time Factors, Treatment Outcome, Cisapride therapeutic use, Digestive System Diseases drug therapy, Enteral Nutrition, Gastrointestinal Agents therapeutic use, Infant, Premature, Diseases drug therapy
Abstract

To evaluate the efficacy of cisapride in improving tolerance of enteral feeding, 59 premature infants were randomized into a blinded placebo-controlled study. Treatment was initiated with the introduction of enteral feeding and continued until 150 ml/kg/day of milk were tolerated. Only in extremely low birth weight (ELBW) infants, was the time to tolerate full enteral feeding shorter in the treatment group, whereas ECG recordings showed a significantly prolonged QTc interval during treatment. Two children developed cardiac rhythm disturbances. In conclusion premature infants may not benefit from routine use of the drug to improve enteral feeding, and seem to be more vulnerable to its side effects.

Published
2005
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