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Long-standing cholestatic syndrome (LSCS) was diagnosed in 41 patients with hepatitis A and hepatitis A plus chronic persistent hepatitis B (HA + CPHB). Some patients had a cholestatic form of the disease. Morphological and morphometric liver parameters were measured at the height of icterus in 74 patients. It was found that cholestatic syndrome in patients with HA and HA = CPHB is related to reparative regeneration which always has a favourable outcome.

Aim: To assess effectiveness of Deka-Duraboline--preparation of anabolic steroid hormone (nandrolone decanoate)--in the treatment of weight loss in AIDS patients., Materials and Methods: 13 AIDS patients with weight loss < 10% admitted to Moscow Center of AIDS Prevention and Treatment were given Deka-Durabolin 1 time a week 50 mg intramuscularly for 12 weeks after failure of attempts to arrest weight loss. Body mass, diarrhea, appetite and general condition (visual analogue scale) were studied., Results: Deka-Duraboline treatment arrested weight loss in 12 of 13 cases, improved well-being. All the patients displayed better appetite, reduced diarrhea., Conclusion: Deka-Duraboline is effective in improving body weight, appetite, diarrhea and well-being in AIDS patients. It is advisable to further study Deka-Duraboline in a controlled randomized trial.

Clinical and morphological characteristics were studied for a course of acute viral hepatitis A and delta with long-term cholestatic syndrome in asymptomatic carriers of HBsAg. 149 patients with moderate disease were examined, 53 of them had long-standing cholestasis syndrome. 96 viral hepatitis patients free of cholestasis served control. It is believed that the emergence of long-term intrahepatic cholestasis may be due to the following mechanisms of sinusoid lumina as a result of a drastic enlargement of multinuclear hepatocytes, hyperplasia and hypertrophy of Kupffer's cells. impaired binding of bilirubin in zone III of hepatic acinus. In cholestatic form of hepatitis A there occurs more pronounced reduction of sinusoid volume compared to other variants of viral hepatitis run.