131 results on '"Ivana Savic"'
Search Results
2. ASIC1a senses lactate uptake to regulate metabolism in neurons
- Author
-
Ivana Savic Azoulay, Xin Qi, Maya Rozenfeld, Fan Liu, Qin Hu, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Michael X. Zhu, Tian-Le Xu, and Israel Sekler
- Subjects
ASIC1a ,Cytosolic Na+ signaling ,Cytosolic Ca2+ signaling ,Mitochondrial Na+ signaling ,Mitochondrial Ca2+ signaling ,NCLX ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca2+, Mg2+ and Zn2+, that block the channel pore. Here, by monitoring lactate-evoked H+ and Ca2+ transport in cultured mouse cortical and hippocampal neurons, we find that stereo-selective neuronal uptake of L-lactate results in rapid intracellular acidification that triggers H+ extrusion to activate plasma membrane ASIC1a channels, leading to propagating Ca2+ waves into the cytosol and mitochondria. We show that lactate activates ASIC1a at its physiological concentrations, far below that needed to chelate divalent cations. The L-isomer of lactate exerts a much greater effect on ASIC1a-mediated activity than the d-isomer and this stereo-selectivity arises from lactate transporters, which prefer the physiologically common L-lactate. The lactate uptake in turn results in intracellular acidification, which is then followed by a robust acid extrusion. The latter response sufficiently lowers the pH in the vicinity of the extracellular domain of ASIC1a to trigger its activation, resulting in cytosolic and mitochondrial Ca2+ signals that accelerate mitochondrial respiration. Furthermore, blocking ASIC1a led to a robust mitochondrial ROS production induced by L-lactate. Together our results indicate that ASIC1a is a metabolic sensor, which by sensing extracellular pH drop triggered by neuronal lactate uptake with subsequent proton extrusion, transmits a Ca2+ response that is propagated to mitochondria to enhance lactate catabolism and suppress ROS production.
- Published
- 2022
- Full Text
- View/download PDF
3. Expression of connexin-43 in surgical resections of primary tumor and lymph node metastases of squamous cell carcinoma and adenocarcinoma of the lung: a retrospective study
- Author
-
Ivana Savic, Petar Milovanovic, Svetlana Opric, Nebojsa Ivanovic, and Dejan Oprić
- Subjects
Lung cancer ,Connexin-43 ,Immunohistochemistry ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background Connexins are transmembrane proteins forming gap junctions between the cells, which allow intercellular communication. Significance of gap junctions and connexins in lung carcinoma is not yet understood. The objective of the study was to investigate immunohistochemical expression and the localization of connexin-43 (Cx43) in primary lung carcinoma and its lymphatic metastases. Methods Surgical specimens of excised tumors from 88 patients (45 men and 43 women, 61.9 ± 7.4 years) with lung carcinoma (52 adenocarcinoma (AC), 36 squamous cell carcinoma (SqCC)) who were operated on at the University Hospital “Bezanijska Kosa” in a five-year period (2012–2016) were used. We conducted immunohistochemical staining for Cx43 and measured the degree of expression (percentage of positive cells and staining intensity) as well as localization of Cx43 in primary tumor and in lymphatic metastases. Results Immunohistochemical analysis of the primary tumors revealed that SqCC showed significantly higher percentage of tumor cells expressing Cx43 as well as higher staining intensity than AC (p
- Published
- 2022
- Full Text
- View/download PDF
4. Bioengineering Outlook on Cultivated Meat Production
- Author
-
Ivana Pajčin, Teodora Knežić, Ivana Savic Azoulay, Vanja Vlajkov, Mila Djisalov, Ljiljana Janjušević, Jovana Grahovac, and Ivana Gadjanski
- Subjects
cultured meat ,cultivated meat ,cell-based meat ,cellular agriculture ,bioengineering ,tissue engineering ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
Cultured meat (also referred to as cultivated meat or cell-based meat)—CM—is fabricated through the process of cellular agriculture (CA), which entails application of bioengineering, i.e., tissue engineering (TE) principles to the production of food. The main TE principles include usage of cells, grown in a controlled environment provided by bioreactors and cultivation media supplemented with growth factors and other needed nutrients and signaling molecules, and seeded onto the immobilization elements—microcarriers and scaffolds that provide the adhesion surfaces necessary for anchor-dependent cells and offer 3D organization for multiple cell types. Theoretically, many solutions from regenerative medicine and biomedical engineering can be applied in CM-TE, i.e., CA. However, in practice, there are a number of specificities regarding fabrication of a CM product that needs to fulfill not only the majority of functional criteria of muscle and fat TE, but also has to possess the sensory and nutritional qualities of a traditional food component, i.e., the meat it aims to replace. This is the reason that bioengineering aimed at CM production needs to be regarded as a specific scientific discipline of a multidisciplinary nature, integrating principles from biomedical engineering as well as from food manufacturing, design and development, i.e., food engineering. An important requirement is also the need to use as little as possible of animal-derived components in the whole CM bioprocess. In this review, we aim to present the current knowledge on different bioengineering aspects, pertinent to different current scientific disciplines but all relevant for CM engineering, relevant for muscle TE, including different cell sources, bioreactor types, media requirements, bioprocess monitoring and kinetics and their modifications for use in CA, all in view of their potential for efficient CM bioprocess scale-up. We believe such a review will offer a good overview of different bioengineering strategies for CM production and will be useful to a range of interested stakeholders, from students just entering the CA field to experienced researchers looking for the latest innovations in the field.
- Published
- 2022
- Full Text
- View/download PDF
5. 'Heart in DRESS': Cardiac Manifestations, Treatment and Outcome of Patients with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: A Systematic Review
- Author
-
Milan Radovanovic, Djordje Jevtic, Andrew D. Calvin, Marija Petrovic, Margaret Paulson, Libardo Rueda Prada, Lawrence Sprecher, Ivana Savic, and Igor Dumic
- Subjects
myocarditis ,heart failure ,drug reaction ,pericarditis ,DRESS syndrome ,drug hypersensitivity ,Medicine - Abstract
Cardiac involvement in drug reaction with eosinophilia and systemic symptoms (DS) is rare but associated with high mortality. The aim of this research was to systematically review case reports by PRISMA guidelines in order to synthetize the knowledge of cardiac manifestations of DS. We identified 42 cases from 36 case reports. Women were two times more affected than men. Two-thirds of patients had cardiac manifestation in the initial phase of the disease, while in one-third of cases cardiac manifestations developed later (mean time of 70 ± 63 days). The most common inciting medications were minocycline (19%) and allopurinol (12%). In 17% of patients, the heart was the only internal organ affected, while the majority (83%) had at least one additional organ involved, most commonly the liver and the kidneys. Dyspnea (55%), cardiogenic shock (43%), chest pain (38%), and tachycardia (33%) were the most common cardiac signs and symptoms reported. Patients frequently had an abnormal ECG (71.4%), and a decrease in left ventricular ejection fraction was the most common echocardiographic finding (45%). Endomyocardial biopsy or histological examination at autopsy was performed in 52.4%, with the predominant finding being fulminant eosinophilic myocarditis with acute necrosis in 70% of those biopsied. All patients received immunosuppressive therapy with intravenous steroids, while non-responders were more likely to have received IVIG, cyclosporine, mycophenolate, and other steroid-sparing agents (60%). Gender and degree of left ventricular systolic dysfunction were not associated with outcomes, but short latency between drug exposure and the first DRESS symptom onset (
- Published
- 2022
- Full Text
- View/download PDF
6. Author Correction: Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
- Author
-
Alexandra Stavsky, Ohad Stoler, Marko Kostic, Tomer Katoshevsky, Essam A. Assali, Ivana Savic, Yael Amitai, Holger Prokisch, Steffen Leiz, Cornelia Daumer-Haas, Ilya Fleidervish, Fabiana Perocchi, Daniel Gitler, and Israel Sekler
- Subjects
Biology (General) ,QH301-705.5 - Published
- 2021
- Full Text
- View/download PDF
7. Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study
- Author
-
Ivana Savic Milovanovic, Mihailo Stjepanovic, and Dragan Mitrovic
- Subjects
Autopsy ,distribution ,histological type ,lung cancer ,metastases ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Introduction: Lung cancer is among leading causes of death worldwide. Different histological types of the lung carcinoma show significant differences in behavior. Objectives: The aim of this study is to determine the distribution patterns of metastases of different lung cancer histological types in autopsied individuals. Methods: Protocols from all autopsies performed at the Institute of Pathology from 2008 till 2014 were reviewed retrospectively, and information on individuals' age, sex, histological type of primary lung cancer, presence and location of metastases, and causes of death were recorded. Results: More than 90% of the individuals with lung cancer metastases were older than 50 years (mean age: 64.5 ± 10.3), with two-fold male predominance. The most frequent histological type in both sexes was adenocarcinoma (48%). Although, in general, hematogenous metastases were mostly found in the liver and adrenal glands, various histological types of lung cancer show specific dissemination patterns. Metastases in adrenal glands derived mostly from adenocarcinoma and large-cell carcinoma. Metastases in the intestines most frequently originated from large-cell carcinoma (P = 0.01). Metastatic complications and bronchopneumonia were the most frequent causes of death. Conclusions: While, overall, the most frequent hematogenous metastases occur in the liver and adrenal glands, various histological types of lung cancer show specific dissemination patterns. Knowing distribution of metastases is essential for making algorithms of treatment, as well as for improving clinical assessment of the patients with unclear clinical findings and suspicion on occult primary lung cancer.
- Published
- 2017
- Full Text
- View/download PDF
8. Clinically unrecognized miliary tuberculosis: an autopsy study
- Author
-
Ivana Savic, Vesna Trifunovic-Skodric, and Dragan Mitrovic
- Subjects
Medicine - Abstract
BACKGROUND: Miliary tuberculosis (TB) usually presents with atypical clinical manifestations; thus it is often recognized only at autopsy. OBJECTIVES: Our objectives were to study the frequency of MT diagnosed at autopsy and determine clinical diagnoses that masked TB, as well as causes of death and comorbidities. DESIGN: Retrospective study of all autopsies performed between 2008 and 2014. SETTING: Institute of Pathology, Belgrade, Serbia. SUBJECTS AND METHODS: In subjects where autopsy showed the presence of MT that was not recognized clinically, we recorded the clinical diagnoses (presumed causes of death) as reported in autopsy request forms, as well as actual cause of death and comorbidities as determined at autopsy. MAIN OUTCOME MEASURES: Clinically unrecognized MT. RESULTS: The total number of autopsies in this period was 6206. Thirty-five individuals showed clinically unrecognized MT (0.56% of all autopsies, age: 62.2 [17.2] years, M:F=2:3). Common clinical diagnoses masking pulmonary MT were exacerbation of COPD (25%) and pulmonary thromboembolism (25%), with common radiological presentation of diffuse pulmonary infiltrates (56.3%). Dominant clinical diagnoses in patients with generalized MT were adult respiratory distress syndrome, sepsis, gastrointestinal bleeding and meningoencephalitis. Disseminated MT was often associated with secondary anemia or thrombocytopenia (15.8%) and recent surgery (15.8%). Frequent comorbidities included chronic renal failure and malignancies, whereas MT was a dominant cause of death. CONCLUSION: Greater awareness of MT is needed to improve recognition in clinical settings. In particular, MT should be considered in patients with atypical clinical presentation and diffuse pulmonary infiltrates on chest X-ray, particularly if they have chronic renal failure, malignancy, hematological disorders or a history of recent surgery. LIMITATIONS: None.
- Published
- 2016
- Full Text
- View/download PDF
9. Physico-Chemical Properties and Oxidative Stability of Fixed Oil from Plum Seeds (Prunus domestica Linn.)
- Author
-
Ivan Savic, Ivana Savic Gajic, and Dragoljub Gajic
- Subjects
oil extraction ,solvent polarity ,oxidative stability ,antioxidant activity ,hplc analysis ,Microbiology ,QR1-502 - Abstract
Storage of a great amount of plum kernel waste becomes a challenge for food industry. In this work, the plum seed was used as a source of fixed oil that can be an ingredient of commercial products. Soxhlet extraction was carried out using the different solvents, such as n-hexane, n-heptane, ethyl acetate, acetone, or chloroform:methanol mixture (2:1 v/v). The highest yield of oil (about 30%) was obtained using n-heptane and n-hexane, while the lowest yield was obtained using ethyl acetate. The analysis of physico-chemical parameters indicated that all samples of plum seed oil have an exceptional quality. Schaal oven test indicated that the fixed oil of plum seed exhibited satisfactory oxidative stability at moderate storage temperatures (up to 65 °C). The composition of phenolic compounds in the oil samples was determined using HPLC method. The most abundant compound of seven identified and quantified phenolic compounds was vanillic acid. The highest content of β-carotene (1.67 mg 100 g−1 fixed oil) spectrophotometrically determined was in the oil extracted with n-hexane. The lowest content of β-carotene (1.26 mg 100 g−1 fixed oil) was determined in the oil extracted with a mixture of chloroform:methanol (2:1 v/v). This oil had the highest antioxidant activity (IC50 value of 4.35 mg mL−1) compared to other oil samples. The antioxidant activity was probably caused by the presence of phenolic compounds. The investigated physico-chemical properties demonstrated that the plum seed oil has a potential for application in the food, cosmetics, and pharmaceutical industry.
- Published
- 2020
- Full Text
- View/download PDF
10. Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Black Locust (Robiniae Pseudoacaciae) Flowers and Comparison with Conventional Methods
- Author
-
Ivana Savic Gajic, Ivan Savic, Ivana Boskov, Stanko Žerajić, Ivana Markovic, and Dragoljub Gajic
- Subjects
extraction ,phenolic compounds ,antioxidants ,central composite design ,optimization ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The aim of this study was to optimize the ultrasound-assisted extraction of phenolic compounds from black locust (Robiniae pseudoacaciae) flowers using central composite design. The ethanol concentration (33−67%), extraction temperature (33−67 °C), and extraction time (17−33 min) were analyzed as the factors that impact the total phenolic content. The liquid-to-solid ratio of 10 cm3 g−1 was the same during extractions. The optimal conditions were found to be 59 °C, 60% (v/v) ethanol, and extraction time of 30 min. The total phenolic content (TPC = 3.12 gGAE 100 g−1 dry plant material) and antioxidant activity (IC50 = 120.5 µg cm−3) of the extract obtained by ultrasound-assisted extraction were compared with those obtained by maceration (TPC = 2.54 gGAE 100 g−1 dry plant material, IC50 = 150.6 µg cm−3) and Soxhlet extraction (TPC = 3.22 gGAE 100 g−1 dry plant material, IC50 = 204.2 µg cm−3). The ultrasound-assisted extraction gave higher total phenolic content and better antioxidant activity for shorter extraction time so that it represents the technique of choice for the extraction of phenolic compounds. The obtained extract, as the source of antioxidants, can be applied in the pharmaceutical and food industries.
- Published
- 2019
- Full Text
- View/download PDF
11. Online Condition Monitoring of Bearings to Support Total Productive Maintenance in the Packaging Materials Industry
- Author
-
Jovan Gligorijevic, Dragoljub Gajic, Aleksandar Brkovic, Ivana Savic-Gajic, Olga Georgieva, and Stefano Di Gennaro
- Subjects
total productive maintenance ,reliability ,bearings ,fault diagnosis ,wavelet transform ,statistical pattern recognition ,Chemical technology ,TP1-1185 - Abstract
The packaging materials industry has already recognized the importance of Total Productive Maintenance as a system of proactive techniques for improving equipment reliability. Bearing faults, which often occur gradually, represent one of the foremost causes of failures in the industry. Therefore, detection of their faults in an early stage is quite important to assure reliable and efficient operation. We present a new automated technique for early fault detection and diagnosis in rolling-element bearings based on vibration signal analysis. Following the wavelet decomposition of vibration signals into a few sub-bands of interest, the standard deviation of obtained wavelet coefficients is extracted as a representative feature. Then, the feature space dimension is optimally reduced to two using scatter matrices. In the reduced two-dimensional feature space the fault detection and diagnosis is carried out by quadratic classifiers. Accuracy of the technique has been tested on four classes of the recorded vibrations signals, i.e., normal, with the fault of inner race, outer race, and ball operation. The overall accuracy of 98.9% has been achieved. The new technique can be used to support maintenance decision-making processes and, thus, to increase reliability and efficiency in the industry by preventing unexpected faulty operation of bearings.
- Published
- 2016
- Full Text
- View/download PDF
12. A case of a large pedunculated-type osteochondroma from late medieval Ilok, eastern Croatia: Bioarchaeological, paleoradiological and histological study
- Author
-
Čavka, Mislav, Erjavec, Igor, Seiwerth, Sven, Carić, Mario, Janković, Ivor, Krznar, Siniša, Rimpf, Andrea, Brkić, Hrvoje, Pavičin, Ivana Savić, Vodanović, Marin, and Novak, Mario
- Published
- 2022
- Full Text
- View/download PDF
13. Centric slide in different Angle's classes of occlusion
- Author
-
Čimić, Samir, Badel, Tomislav, Šimunković, Sonja Kraljević, Pavičin, Ivana Savić, and Ćatić, Amir
- Published
- 2016
- Full Text
- View/download PDF
14. Timing of emergence of the first primary tooth in preterm and full-term infants
- Author
-
Pavičin, Ivana Savić, Dumančić, Jelena, Badel, Tomislav, and Vodanović, Marin
- Published
- 2016
- Full Text
- View/download PDF
15. Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival and learning
- Author
-
Rozenfeld, Maya, primary, Azoulay, Ivana Savic, additional, Ben Kasus Nissim, Tsipi, additional, Stavsky, Alexandra, additional, Melamed, Moran, additional, Stutzmann, Grace, additional, Hershfinkel, Michal, additional, Kofman, Ora, additional, and Sekler, Israel, additional
- Published
- 2022
- Full Text
- View/download PDF
16. Analytical Sensitivity of Lateral Flow Devices against SARS-CoV-2 Omicron Subvariants BA.4, BA.5, and BA.2.75
- Author
-
Charlene Mackenzie, Mitchell Batty, Georgina Papadakis, Laura Stevens, Yano Yoga, George Taiaroa, Helen Stefanatos, Ivana Savic, Thomas Tran, Joshua Deerain, Jacqueline Prestedge, Julian Druce, Leon Caly, and Deborah A. Williamson
- Subjects
Microbiology (medical) ,SARS-CoV-2 ,Humans ,COVID-19 ,Antibodies, Viral ,Cell Line - Published
- 2022
17. Maintaining genomic surveillance using whole-genome sequencing of SARS-CoV-2 from rapid antigen test devices
- Author
-
Genevieve E Martin, George Taiaroa, Mona L Taouk, Ivana Savic, Jacinta O'Keefe, Robert Quach, Jacqueline Prestedge, Marcelina Krysiak, Leon Caly, and Deborah A Williamson
- Subjects
Infectious Diseases ,Whole Genome Sequencing ,SARS-CoV-2 ,COVID-19 ,Humans ,Genome, Viral ,Genomics - Published
- 2022
18. Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
- Author
-
Tomer Katoshevsky, Fabiana Perocchi, Daniel Gitler, Essam A. Assali, Steffen Leiz, Ohad Stoler, Marko Kostic, Yael Amitai, Ilya A. Fleidervish, Ivana Savic, Israel Sekler, Alexandra Stavsky, Holger Prokisch, and Cornelia Daumer-Haas
- Subjects
0301 basic medicine ,QH301-705.5 ,Neural facilitation ,Medicine (miscellaneous) ,chemistry.chemical_element ,Neurotransmission ,Calcium ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Cellular neuroscience ,medicine ,Synaptic transmission ,Biology (General) ,Calcium signaling ,Calcium metabolism ,Calcium signalling ,Long-term potentiation ,Mitochondria ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Schaffer collateral ,General Agricultural and Biological Sciences ,030217 neurology & neurosurgery - Abstract
Calcium dynamics control synaptic transmission. Calcium triggers synaptic vesicle fusion, determines release probability, modulates vesicle recycling, participates in long-term plasticity and regulates cellular metabolism. Mitochondria, the main source of cellular energy, serve as calcium signaling hubs. Mitochondrial calcium transients are primarily determined by the balance between calcium influx, mediated by the mitochondrial calcium uniporter (MCU), and calcium efflux through the sodium/lithium/calcium exchanger (NCLX). We identified a human recessive missense SLC8B1 variant that impairs NCLX activity and is associated with severe mental retardation. On this basis, we examined the effect of deleting NCLX in mice on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity. Neuronal mitochondria exhibited basal calcium overload, membrane depolarization, and a reduction in the amplitude and rate of calcium influx and efflux. We observed smaller cytoplasmic calcium transients in the presynaptic terminals of NCLX-KO neurons, leading to a lower probability of release and weaker transmission. In agreement, synaptic facilitation in NCLX-KO hippocampal slices was enhanced. Importantly, deletion of NCLX abolished long term potentiation of Schaffer collateral synapses. Our results show that NCLX controls presynaptic calcium transients that are crucial for defining synaptic strength as well as short- and long-term plasticity, key elements of learning and memory processes., Stavsky et al. examined the effects of deleting the mitochondrial sodium/lithium/calcium exchanger, NCLX, on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity in mice. Having identified a human mutation that impairs NCLX activity and is associated with mental retardation, they show that NCLX is crucial for defining synaptic strength and plasticity, which are pivotal elements of learning and memory.
- Published
- 2021
19. Pathogenesis of Pulmonary Calcification and Homologies with Biomineralization in Other Tissues
- Author
-
Ivana Savic, Carol Farver, and Petar Milovanovic
- Subjects
Pathology and Forensic Medicine - Abstract
Lungs often present tissue calcifications and even ossifications, both in the context of high or normal serum calcium levels. Precise mechanisms governing lung calcifications have not been explored. Herein, we emphasize recent advances about calcification processes in other tissues (especially vascular and bone calcifications) and discuss potential sources of calcium precipitates in the lungs, involvement of mineralization promoters and crystallization inhibitors, as well as specific cytokine milieu and cellular phenotypes characteristic for lung diseases, which may be involved in pulmonary calcifications. Further studies are necessary to demonstrate the exact mechanisms underlying calcifications in the lungs, document homologies in biomineralization processes between various tissues in physiological and pathologic conditions, and unravel any locally specific characteristics of mineralization processes that may be targeted to reduce or prevent functionally relevant lung calcifications without negatively affecting the skeleton.
- Published
- 2022
20. Monkeypox infection presenting as genital rash, Australia, May 2022
- Author
-
Yael Hammerschlag, Gina MacLeod, Georgina Papadakis, Asiel Adan Sanchez, Julian Druce, George Taiaroa, Ivana Savic, Jamie Mumford, Jason Roberts, Leon Caly, Deborah Friedman, Deborah A Williamson, Allen C Cheng, and James H McMahon
- Subjects
Male ,Epidemiology ,Virology ,Public Health, Environmental and Occupational Health ,Humans ,HIV Infections ,Genitalia ,Monkeypox ,Exanthema ,Viral Load - Abstract
Rapid diagnosis and whole genome sequencing confirmed a case of monkeypox in an HIV-positive individual receiving antiretroviral therapy. The patient had a normal CD4+ T-cell count and suppressed HIV viral load and presented with a genital rash in Melbourne, Australia after return from Europe in May 2022. He subsequently developed systemic illness and disseminated rash and 11 days after symptom onset, he was hospitalised to manage painful bacterial cellulitis of the genital area.
- Published
- 2022
21. ASIC1a senses lactate uptake to regulate metabolism in neurons
- Author
-
Azoulay, Ivana Savic, primary, Qi, Xin, additional, Rozenfeld, Maya, additional, Liu, Fan, additional, Hu, Qin, additional, Ben Kasus Nissim, Tsipi, additional, Stavsky, Alexandra, additional, Zhu, Michael X., additional, Xu, Tian-Le, additional, and Sekler, Israel, additional
- Published
- 2022
- Full Text
- View/download PDF
22. Development of the Sustainable Extraction Procedures of Bioactive Compounds from Industrial Food Wastes and Their Application in the Products for Human Uses
- Author
-
Ivan Savic and Ivana Savic Gajic
- Subjects
Renewable Energy, Sustainability and the Environment ,Geography, Planning and Development ,Building and Construction ,Management, Monitoring, Policy and Law - Abstract
Reducing natural resources caused by the growth of the world’s population, meeting the growing demands of consumers, and preventing environmental pollution requires the development of sustainable and efficient procedures that include the valorization of wastes [...]
- Published
- 2023
23. Giant thermoelectric power factor in charged ferroelectric domain walls of GeTe with Van Hove singularities
- Author
-
Ðorđe Dangić, Ivana Savic, and Stephen Fahy
- Subjects
Materials science ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,symbols.namesake ,QA76.75-76.765 ,Electrical resistivity and conductivity ,Seebeck coefficient ,Thermoelectric effect ,General Materials Science ,Computer software ,Electronic band structure ,Materials of engineering and construction. Mechanics of materials ,Condensed matter physics ,Fermi level ,021001 nanoscience & nanotechnology ,Thermoelectric materials ,Ferroelectricity ,0104 chemical sciences ,Computer Science Applications ,Mechanics of Materials ,Modeling and Simulation ,symbols ,TA401-492 ,Charge carrier ,0210 nano-technology - Abstract
Increasing the Seebeck coefficient S in thermoelectric materials usually drastically decreases the electrical conductivity σ, making significant enhancement of the thermoelectric power factor σS2 extremelly challenging. Here we predict, using first-principles calculations, that the extraordinary properties of charged ferroelectric domain walls (DWs) in GeTe enable a five-fold increase of σS2 in the DW plane compared to bulk. The key reasons for this enhancement are the confinement of free charge carriers at the DWs and Van Hove singularities in the DW electronic band structure near the Fermi level. These effects lead to an increased energy dependence of the DW electronic transport properties, resulting in more than a two-fold increase of S with respect to bulk, without considerably degrading the in-plane σ. We propose a design of a nano-thermoelectric device that utilizes the exceptional thermoelectric properties of charged ferroelectric DWs. Our findings should inspire further investigation of ferroelectric DWs as efficient thermoelectric materials.
- Published
- 2020
24. ASIC1a channels regulate mitochondrial ion signaling and energy homeostasis in neurons
- Author
-
Michael X. Zhu, Maya Rozenfeld, Fan Liu, Tian-Le Xu, Tsipi Ben Kasus Nissim, Ivana Savic Azoulay, Qin Hu, and Israel Sekler
- Subjects
0301 basic medicine ,Mitochondrion ,Biochemistry ,Article ,Energy homeostasis ,Mice ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Live cell imaging ,Psalmotoxin ,Extracellular ,Animals ,Homeostasis ,Ion channel ,Gene knockout ,Cerebral Cortex ,Mice, Knockout ,Neurons ,Hydrogen-Ion Concentration ,Mitochondria ,Cell biology ,Acid Sensing Ion Channels ,Mice, Inbred C57BL ,Cytosol ,030104 developmental biology ,chemistry ,Energy Metabolism ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Acid sensing ion channel 1a (ASIC1a) is well-known to play a major pathophysiological role during brain ischemia linked to acute acidosis of ~ pH 6, while its function during physiological brain activity, linked to much milder pH changes, is still poorly understood. Here, by performing live cell imaging utilizing Na(+) and Ca(2+) sensitive and spatially specific fluorescent dyes, we investigated the role of ASIC1a in cytosolic Na(+) and Ca(2+) signals elicited by a mild extracellular drop from pH 7.4 to 7.0 and how these affect mitochondrial Na(+) and Ca(2+) signaling or metabolic activity. We show that in mouse primary cortical neurons, this small extracellular pH change triggers cytosolic Na(+) and Ca(2+) waves that propagate to mitochondria. Inhibiting ASIC1a with Psalmotoxin 1 (PcTX1) or ASIC1a gene knockout blocked not only the cytosolic but also the mitochondrial Na(+) and Ca(2+) signals. Moreover, physiological activation of ASIC1a by this pH shift enhances mitochondrial respiration and evokes mitochondrial Na(+) signaling even in digitonin - permeabilized neurons. Altogether our results indicate that ASIC1a is critical in linking physiological extracellular pH stimuli to mitochondrial ion signaling and metabolic activity and thus is an important metabolic sensor.
- Published
- 2020
25. Drug design strategies with metal-hydroxyquinoline complexes
- Author
-
Ivan M. Savic and Ivana Savic-Gajic
- Subjects
Drug ,Modern medicine ,Metal ions in aqueous solution ,media_common.quotation_subject ,Brain cancer ,Metal ,03 medical and health sciences ,0302 clinical medicine ,Drug Development ,Coordination Complexes ,Drug Discovery ,Humans ,030304 developmental biology ,media_common ,0303 health sciences ,Chemistry ,Biological activity ,Oxyquinoline ,Combinatorial chemistry ,Transition metal ions ,Solubility ,Blood-Brain Barrier ,Drug Design ,030220 oncology & carcinogenesis ,visual_art ,Lipophilicity ,visual_art.visual_art_medium ,Hydrophobic and Hydrophilic Interactions - Abstract
Introduction: 8-hydroxyquinoline derivatives and their complexes with transition metals are the subject of many studies due to their anticancer, anti-inflammatory, anti-infective, and antidiabetic activities.Areas covered: Within this article, the authors review the synthesis and current applications of metal-8-hydroxyquinoline complexes in drug design with a critical overview of the latest advancements in the field.Expert opinion: Metal-8-hydroxyquinoline complexes are especially interesting because of their simple synthesis procedures and possible applications in modern medicine. The complexation between transition metal ions and 8-hydroxyquinoline or its derivatives is achieved via their O and N atoms. The main problem with their application is lipophilicity. This particular property has an impact on their solubility, biological activity, transport through the cell membrane, construction of the complex with a receptor, and development of drugs. Furthermore, in the treatment of neurodegenerative diseases and brain cancers, the passage of the complexes through the blood-brain barrier can only be ensured through novel drug design.
- Published
- 2019
26. Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival and learning
- Author
-
Maya Rozenfeld, Ivana Savic Azoulay, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Moran Melamed, Grace Stutzmann, Michal Hershfinkel, Ora Kofman, and Israel Sekler
- Subjects
General Biochemistry, Genetics and Molecular Biology - Published
- 2022
27. Essential role of the mitochondrial Na
- Author
-
Maya, Rozenfeld, Ivana Savic, Azoulay, Tsipi, Ben Kasus Nissim, Alexandra, Stavsky, Moran, Melamed, Grace, Stutzmann, Michal, Hershfinkel, Ora, Kofman, and Israel, Sekler
- Abstract
Impaired phosphodiesterase (PDE) function and mitochondrial Ca
- Published
- 2021
28. Electron-phonon coupling and electronic thermoelectric properties of n -type PbTe driven near the soft-mode phase transition via lattice expansion
- Author
-
Jiang Cao, José D. Querales-Flores, Stephen Fahy, Đorđe Dangić, and Ivana Savic
- Subjects
Phase transition ,Materials science ,Phonon ,Population ,FOS: Physical sciences ,02 engineering and technology ,Soft modes ,01 natural sciences ,n-type PbTe ,Condensed Matter::Materials Science ,0103 physical sciences ,Thermoelectric effect ,Soft-mode phase transition ,010306 general physics ,education ,Electronic thermoelectric properties ,Condensed Matter - Materials Science ,education.field_of_study ,Condensed matter physics ,Scattering ,Materials Science (cond-mat.mtrl-sci) ,Electron-phonon coupling ,Computational Physics (physics.comp-ph) ,021001 nanoscience & nanotechnology ,Thermoelectric materials ,3. Good health ,Phase space ,Lattice expansion ,0210 nano-technology ,Physics - Computational Physics - Abstract
IV-VI materials are some of the most efficient bulk thermoelectric materials due to their proximity to soft-mode phase transitions, which leads to low lattice thermal conductivity. It has been shown that the lattice thermal conductivity of PbTe can be considerably reduced by bringing PbTe closer to the phase transition e.g. via lattice expansion. However, the effect of soft phonon modes on the electronic thermoelectric properties of such system remains unknown. Using first principles calculations, we show that the soft zone center transverse optical phonons do not deteriorate the electronic thermoelectric properties of PbTe driven closer to the phase transition via lattice expansion due to external stress, and thus enhance the thermoelectric figure of merit. We find that the optical deformation potentials change very weakly as the proximity to the phase transition increases, but the population and scattering phase space of soft phonon modes increase. Nevertheless, scattering between electronic states near the band edge and soft optical phonons remains relatively weak even very near the phase transition., 8 pages, 7 figures
- Published
- 2021
29. The mitochondrial Na+/Ca2+ exchanger, NCLX, mediates PDE2 dependent neuronal survival and learning
- Author
-
Alexandra Stavsky, Ivana Savic Azoulay, Ora Kofman, Tsipi Ben Kasus Nissim, Maya Rozenfeld, Israel Sekler, and Michal Hershfinkel
- Subjects
chemistry.chemical_compound ,Chemistry ,PDE Inhibitor ,Phosphorylation ,Phosphodiesterase ,Depolarization ,Efflux ,Hippocampal formation ,Neuronal depolarization ,Caffeine ,Cell biology - Abstract
Impaired phosphodiesterase (PDE) function and mitochondrial Ca2+ - [Ca2+]m signaling leads to cardiac failure, ischemic damage and dysfunctional learning and memory. Yet, a causative link between these pathways is unknown. Here, we fluorescently monitored [Ca2+]m transients in hippocampal neurons evoked by caffeine followed by depolarization. [Ca2+]m efflux was apparent in WT but diminished in neurons deficient in the mitochondrial Na+/Ca2+ exchanger NCLX. Surprisingly, neuronal depolarization-induced Ca2+ transients alone failed to evoke strong [Ca2+]m efflux in WT neurons. Caffeine is also a PDE inhibitor. Pretreatment with the PDE2 inhibitor Bay 60-7550 rescued [Ca2+]m efflux triggered by neuronal depolarization. Inhibition of PDE2 acted by diminishing the Ca2+ dependent reduction of mitochondrial cAMP, thereby promoting NCLX phosphorylation. Selective PDE2 inhibition also enhanced [Ca2+]m efflux triggered by neuromodulators. We found that protection of neurons against excitotoxic insults, conferred by PDE2 inhibition, was diminished in NCLX KO neurons, thus is NCLX dependent. Finally, administration of Bay 60-7550 enhanced new object recognition learning in WT but not in NCLX KO mice. Our results identify a long-sought link between PDE and [Ca2+]m signaling thereby providing new therapeutic targets.
- Published
- 2021
30. Author Correction: Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
- Author
-
Fabiana Perocchi, Ivana Savic, Steffen Leiz, Tomer Katoshevsky, Cornelia Daumer-Haas, Daniel Gitler, Yael Amitai, Essam A. Assali, Israel Sekler, Ohad Stoler, Marko Kostic, Holger Prokisch, Alexandra Stavsky, and Ilya A. Fleidervish
- Subjects
Male ,QH301-705.5 ,Long-Term Potentiation ,Presynaptic Terminals ,Medicine (miscellaneous) ,In Vitro Techniques ,Biology ,Neurotransmission ,Hippocampus ,Synaptic Transmission ,Sodium-Calcium Exchanger ,General Biochemistry, Genetics and Molecular Biology ,Mitochondrial Proteins ,Mice ,Text mining ,Intellectual Disability ,Animals ,Humans ,Point Mutation ,Amino Acid Sequence ,Calcium Signaling ,Biology (General) ,Author Correction ,Mice, Knockout ,Neurons ,Neuronal Plasticity ,business.industry ,Calcium signalling ,Cellular neuroscience ,Mitochondria ,Pedigree ,Mice, Inbred C57BL ,Amino Acid Substitution ,Female ,Cardiomyopathies ,General Agricultural and Biological Sciences ,business ,Neuroscience - Abstract
Calcium dynamics control synaptic transmission. Calcium triggers synaptic vesicle fusion, determines release probability, modulates vesicle recycling, participates in long-term plasticity and regulates cellular metabolism. Mitochondria, the main source of cellular energy, serve as calcium signaling hubs. Mitochondrial calcium transients are primarily determined by the balance between calcium influx, mediated by the mitochondrial calcium uniporter (MCU), and calcium efflux through the sodium/lithium/calcium exchanger (NCLX). We identified a human recessive missense SLC8B1 variant that impairs NCLX activity and is associated with severe mental retardation. On this basis, we examined the effect of deleting NCLX in mice on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity. Neuronal mitochondria exhibited basal calcium overload, membrane depolarization, and a reduction in the amplitude and rate of calcium influx and efflux. We observed smaller cytoplasmic calcium transients in the presynaptic terminals of NCLX-KO neurons, leading to a lower probability of release and weaker transmission. In agreement, synaptic facilitation in NCLX-KO hippocampal slices was enhanced. Importantly, deletion of NCLX abolished long term potentiation of Schaffer collateral synapses. Our results show that NCLX controls presynaptic calcium transients that are crucial for defining synaptic strength as well as short- and long-term plasticity, key elements of learning and memory processes.
- Published
- 2021
31. The mitochondrial Na+/Ca2+exchanger, NCLX, mediates PDE2 dependent neuronal survival and learning
- Author
-
Rozenfeld, Maya, primary, Azoulay, Ivana Savic, additional, Ben Kasus Nissim, Tsipi, additional, Stavsky, Alexandra, additional, Hershfinkel, Michal, additional, Kofman, Ora, additional, and Sekler, Israel, additional
- Published
- 2021
- Full Text
- View/download PDF
32. Discrepancies between clinical and autopsy diagnosis of cause of death among psychiatric patients who died due to natural causes. A retrospective autopsy study
- Author
-
Ivana Savic, Radmila Jankovic, and Mitrović D
- Subjects
lcsh:R5-920 ,Pediatrics ,medicine.medical_specialty ,Autopsy diagnosis ,diagnosis ,business.industry ,hospitals, general ,Autopsy ,patients ,mental disorders ,cause of death ,autopsy ,hospitals, psychiatric ,medicine ,Pharmacology (medical) ,lcsh:Medicine (General) ,business ,death, sudden ,Cause of death - Abstract
Background/Aim. Autopsy studies rarely investigate the causes of natural death in psychiatric population. The aim of this study was to examine the causes of death among the subjects with various psychiatric disorders in whom a clinical (pathoanatomical) autopsy was requested. Methods. The study group included 118 patients (65% men, 35% women, mean age 58.2 ? 13.6 years) with a psychiatric diagnosis, in whom a clinical autopsy was performed. We compared the distribution of causes of natural death among psychiatric patients and other patients, representatives of the general population who died of natural causes. We also analyzed the difference between clinical diagnoses of cause of death and the autopsy findings in psychiatric patients. Results. Psychiatric patients died earlier than the control group (58 vs. 69 years), usually due to the respiratory (46%) and cardiovascular diseases (37%). The most common diagnoses in psychiatric patients were organic psychoses and dementias (F00-F09) and schizophrenia and schizoaffective disorders (F20-F29). Majority of the patients (55%) died in general hospitals vs. specialized psychiatric hospitals (45%) due to somatic diseases. There was a significant difference in the distribution of causes of death compared to the control group in which the cardiovascular diseases dominated. Even in 64% of psychiatric patients there was a discrepancy between the clinical diagnosis of the cause of death and definite autopsy findings. Conclusion. The assessment of somatic diseases in psychiatric patients is insufficient, especially in specialized psychiatric hospitals. That leads to a significant discrepancy between clinical diagnosis of the cause of death and autopsy findings. Therefore, it is necessary to pay additional attention in diagnostics and treatment of somatic diseases in these patients to improve their health care.
- Published
- 2019
33. Update on Diagnosing and Reporting Malignant Pleural Mesothelioma
- Author
-
Ivana Savic and Jeffrey Myers
- Subjects
Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Biomarkers, Tumor ,Humans ,In patient ,Mesothelioma ,Stage (cooking) ,In Situ Hybridization, Fluorescence ,030304 developmental biology ,Sequence Deletion ,0303 health sciences ,BAP1 ,Heterogeneous group ,medicine.diagnostic_test ,business.industry ,Pleural mesothelioma ,Tumor Suppressor Proteins ,Homozygote ,Mesothelioma, Malignant ,General Medicine ,medicine.disease ,Immunohistochemistry ,3. Good health ,030220 oncology & carcinogenesis ,business ,Ubiquitin Thiolesterase ,Fluorescence in situ hybridization - Abstract
In this review, we summarize current approaches to diagnosis of malignant pleural mesothelioma, focusing on the distinction from benign mesothelial proliferations and other malignant tumors. Current recommendations for reporting histological sub-type and tumor grade are also reviewed. Particular emphasis is placed on immunohistochemical and molecular tools that may help in establishing the diagnosis of mesothelioma with greater confidence. Immunohistochemical stains for BRCA1-associated protein (BAP1) and methylthioadenosine phosphorylase (MTAP) and homozygous deletion of p16 using fluorescence in situ hybridization (FISH) are emphasized as important methods for distinguishing benign from malignant mesothelial prolifera- tions.Conclusions. Diffuse malignant pleural mesothelioma is a heterogeneous group of aggressive pleural tumors for which histological classification plays an increasingly important role in patient management. Stage and resectability remain key drivers of therapeutic strategies and outcomes. There is an increasingly robust suite of diagnostic tools, including immunohistochemical stains for BAP1 and MTAP and p16 FISH, for differentiating benign from malignant mesothelial proliferations in cytology and tissue specimens.
- Published
- 2021
34. Essential Role of the Mitochondrial Na +/Ca 2+ Exchanger - NCLX in Mediating the PDE2 Dependent Neuronal Survival and Learning
- Author
-
Ivana Savic, Ora Kofman, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Maya Rozenfeld, Israel Sekler, and Michal Hershfinkel
- Subjects
History ,Polymers and Plastics ,Chemistry ,Excitotoxicity ,Depolarization ,Long-term potentiation ,Hippocampal formation ,Mitochondrion ,medicine.disease_cause ,Industrial and Manufacturing Engineering ,Cell biology ,chemistry.chemical_compound ,medicine ,Phosphorylation ,Efflux ,Business and International Management ,Caffeine - Abstract
Consumption of coffee and caffeine enhances learning efficiency and reduces the risk of stroke and neurodegenerative syndromes by a molecular pathway that is poorly understood. Here we fluorescently monitored mitochondrial Ca2+ transients in hippocampal neurons evoked by caffeine. Surprisingly, caffeine also had a long-lasting potentiation effect on mitochondrial Ca2+ ([Ca2+]m) efflux evoked by depolarization, in WT but not in neurons deficient in the mitochondrial Na+/Ca2+ exchanger NCLX. We reasoned that the caffeine effect is linked to phosphodiesterase inhibition, and focused on PDE2 that has the highest affinity to caffeine and is targeted to the mitochondria. Pretreatment of neurons with the selective PDE2 inhibitor Bay 60-7550 mimicked caffeine and rescued [Ca2+]m efflux triggered by neuronal depolarization. PDE2 inhibition also enhanced [Ca2+]m efflux triggered by neuromodulators. Inhibition of PDE2 acted by increasing mitochondrial cAMP thereby promoting NCLX phosphorylation. We found that protection of neurons against excitotoxic insults, conferred by PDE2 inhibition was diminished in NCLX KO neurons, thus is NCLX dependent. Finally, administration of Bay 60-7550 enhanced new object recognition learning in WT but not in NCLX KO mice. Our results identify a pathway linking caffeine and PDE to [Ca2+]m signaling, thereby providing new therapeutic targets for treating cognitive impairment and excitotoxicity.
- Published
- 2021
35. OROPHARYNGEAL DYSPHAGIA IN ELDERLY PERSONS - ETIOLOGY, PATHOPHYSIOLOGY AND SYMPTOMATOLOGY.
- Author
-
Mirjana, Petrovic-Lazic, Snezana, Babac, and Ivana, Savic
- Subjects
DEGLUTITION disorders ,AGING ,PATHOLOGICAL physiology ,CLINICAL trials - Abstract
Copyright of Sanamed is the property of Sanamed and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
36. The origin of the lattice thermal conductivity enhancement at the ferroelectric phase transition in GeTe
- Author
-
Stephen Fahy, Olle Hellman, Ivana Savic, and Đorđe Dangić
- Subjects
Phase transition ,Materials science ,Phonon ,FOS: Physical sciences ,02 engineering and technology ,01 natural sciences ,QA76.75-76.765 ,Condensed Matter::Materials Science ,Negative thermal expansion ,Phase (matter) ,0103 physical sciences ,General Materials Science ,Computer software ,010306 general physics ,Materials of engineering and construction. Mechanics of materials ,Condensed Matter - Materials Science ,Condensed matter physics ,Anharmonicity ,Materials Science (cond-mat.mtrl-sci) ,021001 nanoscience & nanotechnology ,Thermoelectric materials ,Condensed Matter Physics ,Boltzmann equation ,Ferroelectricity ,Computer Science Applications ,Mechanics of Materials ,Modeling and Simulation ,TA401-492 ,Condensed Matter::Strongly Correlated Electrons ,0210 nano-technology ,Den kondenserade materiens fysik - Abstract
The proximity to structural phase transitions in IV-VI thermoelectric materials is one of the main reasons for their large phonon anharmonicity and intrinsically low lattice thermal conductivity $\kappa$. However, the $\kappa$ of GeTe increases at the ferroelectric phase transition near $700$ K. Using first-principles calculations with the temperature dependent effective potential method, we show that this rise in $\kappa$ is the consequence of negative thermal expansion in the rhombohedral phase and increase in the phonon lifetimes in the high-symmetry phase. Negative thermal expansion increases phonon group velocities, which counteracts enhanced anharmonicity of phonon modes and boosts $\kappa$ close to the phase transition in the rhombohedral phase. A drastic decrease in the anharmonic force constants in the cubic phase increases the phonon lifetimes and $\kappa$. Strong anharmonicity near the phase transition induces non-Lorentzian shapes of the phonon power spectra. To account for these effects, we implement a novel method of calculating $\kappa$ based on the Green-Kubo approach and find that the Boltzmann transport equation underestimates $\kappa$ near the phase transition. Our findings elucidate the influence of structural phase transitions on $\kappa$ and provide guidance for design of better thermoelectric materials.
- Published
- 2020
37. A Fatal Case of Kaposi Sarcoma Immune Reconstitution Syndrome (KS-IRIS) Complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) or Multicentric Castleman Disease (MCD): A Case Report and Review
- Author
-
Oladapo Igandan, Igor Dumic, Djordje Jevtic, Ivana Savic, Charles W. Nordstrom, Anand Subramanian, Poornima Ramanan, and Milan Radovanovic
- Subjects
HIV Kaposi Sarcoma Inflammatory Cytokine Syndrome ,Adult ,Male ,HIV Infections ,Giant Lymph Node Hyperplasia ,Sepsis ,Acquired immunodeficiency syndrome (AIDS) ,Immune Reconstitution Inflammatory Syndrome ,Humans ,Medicine ,Sarcoma, Kaposi ,Acquired Immunodeficiency Syndrome ,Hemophagocytic lymphohistiocytosis ,business.industry ,Castleman Disease ,virus diseases ,Articles ,General Medicine ,medicine.disease ,Pancytopenia ,Systemic Inflammatory Response Syndrome ,Systemic inflammatory response syndrome ,Herpesvirus 8, Human ,Immunology ,Cytokines ,Sarcoma ,Primary effusion lymphoma ,Differential diagnosis ,business - Abstract
Patient: Male, 28-year-old Final Diagnosis: Kaposi sarcoma inflammatory cytokine syndrome (KICS) Symptoms: Abdominal pain • anemia • dyspnea • fever • shock • thrombocytopenia Medication: — Clinical Procedure: Skin biopsy Specialty: Infectious Diseases Objective: Unusual clinical course Background: Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) is a relatively new syndrome described in patients co-infected with Human Immunodeficiency Virus (HIV) and Kaposi Sarcoma (KS) Herpes Virus (KSHV). KICS clinically resembles Multicentric Castleman disease (MCD) and both present with various degrees of lymphadenopathy, pancytopenia, HIV and KSHV viremia, and signs of systemic inflammatory syndrome (SIRS). KICS has higher mortality than MCD and is rarely recognized. Lymph node, bone marrow, or splenic biopsy can help differentiate between the 2 entities. Case Report: We present a case of a 28-year-old African American man with advanced acquired immunodeficiency syndrome (AIDS) who was diagnosed with disseminated pulmonary and cutaneous KS. Following initiation of combined antiretroviral therapy (cART), rapid immunologic recovery occurred followed by rapid clinical deterioration (IRIS) with multiorgan failure, overwhelming SIRS, and ultimately death. The patient’s symptoms, signs, and laboratory findings during this episode could not be solely explained by KS-IRIS, and MCD versus KICS was diagnosed. Conclusions: SIRS in patients with uncontrolled HIV viremia and CD4 lymphopenia has a broad differential diagnosis, including infectious and noninfectious causes. It encompasses sepsis due to common bacterial pathogens, various HIV-specific opportunistic infections, immunological conditions such as hemophagocytic lymphohistiocytosis (HLH), and IRIS, malignancies such as primary effusion lymphoma (PEL) and MCD, and finally KCIS. Clinicians involved in treatment of these patients should have a high index of suspicion for less-known and recently described syndromes such as KICS to recognize it early and initiate timely treatment, which might improve the high mortality associated with KICS.
- Published
- 2020
38. Diachronic Comparison of Three Historical Skeletal Series from Croatia with Regard to Mandibular Bone Quality
- Author
-
Ivana Savić Pavičin, Anita Adamić Hadžić, Tadej Čivljak, Jelena Dumančić, Mario Šlaus, Tomislav Lauc, and Ajla Zymber Çeshko
- Subjects
bone quality ,mandible ,CBCT imaging ,mandibular indices ,archaeological population ,anthropology ,Archaeology ,CC1-960 - Abstract
The aim of this study was to assess the quality of mandibular bone using CBCT images in archeological populations that inhabited Croatia from the medieval to the Early Modern Period. A total of 88 human skulls (45 male and 43 female) from three samples (pre-Ottoman (N = 27), Ottoman (N = 32), and Vlach (N = 29)) were analyzed by using CBCT. The mental index, gonion index, antegonion index, panoramic mandibular index, degree of resorption of the alveolar ridge, and cortical index of the mandible were evaluated using the OnDemand3DApp. The results showed an expected higher value of cortex thickness in males when compared to females. Females in the younger groups had higher values of cortical thickness than those in the older age group. The Ottoman sample had significantly lower values of mandibular indices than the other two samples. There were no age-related differences in bone thickness in males, suggesting that hormonal changes have a stronger influence in females. Lower values of mandibular indices in the Ottoman sample may be an indicator of specific factors that influenced this population. Our study of bone changes in archeological populations with different living conditions may contribute to a better understanding of impact of biocultural factors on physiological and pathological processes, which are extremely complex in bone tissue.
- Published
- 2023
- Full Text
- View/download PDF
39. Electron-phonon scattering and thermoelectric transport in p-type PbTe from first principles
- Author
-
Jiang Cao, Stephen Fahy, Ransell D'Souza, Ivana Savic, and José D. Querales-Flores
- Subjects
Longitudinal optical phonons ,IV-VI semiconductors ,Phonon ,Phonon scattering ,FOS: Physical sciences ,02 engineering and technology ,Lead compounds ,01 natural sciences ,Condensed Matter::Materials Science ,Tellurium compounds ,Electron diffraction ,Thermoelectric performance ,Condensed Matter::Superconductivity ,0103 physical sciences ,Thermoelectric effect ,Electron scattering ,Thermoelectric transport ,Transverse optical modes ,Energy differences ,010306 general physics ,Electron phonon scattering ,Doping concentration ,Scattering mechanisms ,Physics ,Condensed Matter - Materials Science ,Landforms ,Condensed matter physics ,Scattering ,Materials Science (cond-mat.mtrl-sci) ,Thermoelectricity ,021001 nanoscience & nanotechnology ,Thermoelectric materials ,Electron-phonon interactions ,Condensed Matter::Strongly Correlated Electrons ,0210 nano-technology ,Energy (signal processing) - Abstract
We present a first principles based model of electron-phonon scattering mechanisms and thermoelectric transport at the L and $\Sigma$ valleys in $p$-type PbTe, accounting for their thermally induced shifts. Our calculated values of all thermoelectric transport parameters at room temperature are in very good agreement with experiments for a wide range of doping concentrations. Scattering due to longitudinal optical phonons is the main scattering mechanism in $p$-type PbTe, while scattering due to transverse optical modes is the weakest. The L valleys contribute most to thermoelectric transport at 300 K due to the sizeable energy difference between the L and $\Sigma$ valleys. We show that both scattering between the L and $\Sigma$ valleys and additional transport channels of the $\Sigma$ valleys are beneficial for the overall thermoelectric performance of $p$-type PbTe at 300 K. Our findings thus support the idea that materials with high valley degeneracy may be good thermoelectrics., Comment: 16 pages, 6 figures
- Published
- 2020
40. Towards temperature-induced topological phase transition in SnTe: A first-principles study
- Author
-
Piotr Chudzinski, José D. Querales-Flores, Stephen Fahy, Pablo Aguado-Puente, Ivana Savic, Jiang Cao, Đorđe Dangić, Myrta Grüning, and Tchavdar N. Todorov
- Subjects
Condensed Matter - Materials Science ,Phase transition ,Materials science ,Condensed matter physics ,Band gap ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Insulator (electricity) ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Thermal expansion ,Condensed Matter - Other Condensed Matter ,Renormalization ,Topological insulator ,0103 physical sciences ,Topological order ,Condensed Matter::Strongly Correlated Electrons ,010306 general physics ,0210 nano-technology ,Electronic band structure ,Other Condensed Matter (cond-mat.other) - Abstract
The temperature renormalization of the bulk band structure of a topological crystalline insulator, SnTe, is calculated using first principles methods. We explicitly include the effect of thermal-expansion-induced modification of electronic states and their band inversion on electron-phonon interaction. We show that the direct gap decreases with temperature, as both thermal expansion and electron-phonon interaction drive SnTe towards the phase transition to a topologically trivial phase as temperature increases. The band gap renormalization due to electron-phonon interaction exhibits a non-linear dependence on temperature as the material approaches the phase transition, while the lifetimes of the conduction band states near the band edge show a non-monotonic behavior with temperature. These effects should have important implications on bulk electronic and thermoelectric transport in SnTe and other topological insulators., Comment: 10 pages, 8 figures. Accepted for publication in Phys. Rev. B on June 8, 2020
- Published
- 2020
41. The effect of complexation with cyclodextrins on the antioxidant and antimicrobial activity of ellagic acid
- Author
-
Emilija Jocic, Mirjana Popsavin, Ivan M. Savic, Srdjan Rakic, Ivana Savic-Gajic, and Vesna Nikolić
- Subjects
Magnetic Resonance Spectroscopy ,Antioxidant ,medicine.medical_treatment ,Pharmaceutical Science ,02 engineering and technology ,030226 pharmacology & pharmacy ,Antioxidants ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,2 hydroxypropyl β cyclodextrin ,Anti-Infective Agents ,Ellagic Acid ,X-Ray Diffraction ,Candida albicans ,Spectroscopy, Fourier Transform Infrared ,Escherichia coli ,medicine ,Humans ,Organic chemistry ,Cyclodextrins ,Chemistry ,General Medicine ,021001 nanoscience & nanotechnology ,Antimicrobial ,3. Good health ,0210 nano-technology ,Ellagic acid - Abstract
The aim of the paper was to develop the simple procedures for preparation of inclusion complexes of ellagic acid (EA) with cyclodextrins (CDs) and to investigate their antioxidant and antimicrobial activity.The structural characterization was carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and nuclear magnetic resonance (NMR) methods. The phase solubility technique was used to investigate the interactions between 'host' and 'guest' molecules and to estimate the molar ratio between them. The antioxidant and antimicrobial activity of EA and inclusion complexes were determined.The apparent stability constants were found to be 117 dmThe stability constants indicated the rapid release of EA from the inclusion complexes in the aqueous medium at 25 °C. The antioxidant activity of EA was increased, while the antimicrobial activity was preserved after complexation with CDs.
- Published
- 2018
42. Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)
- Author
-
Ivana Lj. Nikolic, Tatjana Kundaković, Ivan M. Savic, and Ivana Savic-Gajic
- Subjects
total flavonoid ,Antioxidant ,Central composite design ,Chemistry ,Process Chemistry and Technology ,General Chemical Engineering ,medicine.medical_treatment ,Extraction (chemistry) ,antioxidant activity ,food and beverages ,Filtration and Separation ,total polyphenol ,02 engineering and technology ,General Chemistry ,010501 environmental sciences ,01 natural sciences ,Chickpea ,020401 chemical engineering ,Polyphenol ,medicine ,Food science ,0204 chemical engineering ,central composite design ,0105 earth and related environmental sciences - Abstract
The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).
- Published
- 2018
43. Physico-Chemical Properties and Oxidative Stability of Fixed Oil from Plum Seeds (
- Author
-
Ivan, Savic, Ivana, Savic Gajic, and Dragoljub, Gajic
- Subjects
solvent polarity ,HPLC analysis ,Plant Extracts ,antioxidant activity ,Prunus domestica ,oxidative stability ,Antioxidants ,Article ,oil extraction ,Oxidative Stress ,Phenols ,Fruit ,Seeds ,Solvents ,Hexanes ,Plant Oils ,Oxidation-Reduction ,Chromatography, High Pressure Liquid - Abstract
Storage of a great amount of plum kernel waste becomes a challenge for food industry. In this work, the plum seed was used as a source of fixed oil that can be an ingredient of commercial products. Soxhlet extraction was carried out using the different solvents, such as n-hexane, n-heptane, ethyl acetate, acetone, or chloroform:methanol mixture (2:1 v/v). The highest yield of oil (about 30%) was obtained using n-heptane and n-hexane, while the lowest yield was obtained using ethyl acetate. The analysis of physico-chemical parameters indicated that all samples of plum seed oil have an exceptional quality. Schaal oven test indicated that the fixed oil of plum seed exhibited satisfactory oxidative stability at moderate storage temperatures (up to 65 °C). The composition of phenolic compounds in the oil samples was determined using HPLC method. The most abundant compound of seven identified and quantified phenolic compounds was vanillic acid. The highest content of β-carotene (1.67 mg 100 g−1 fixed oil) spectrophotometrically determined was in the oil extracted with n-hexane. The lowest content of β-carotene (1.26 mg 100 g−1 fixed oil) was determined in the oil extracted with a mixture of chloroform:methanol (2:1 v/v). This oil had the highest antioxidant activity (IC50 value of 4.35 mg mL−1) compared to other oil samples. The antioxidant activity was probably caused by the presence of phenolic compounds. The investigated physico-chemical properties demonstrated that the plum seed oil has a potential for application in the food, cosmetics, and pharmaceutical industry.
- Published
- 2019
44. Detection of epileptiform activity in EEG signals based on time-frequency and nonlinear analysis.
- Author
-
Dragoljub Gajic, Jovan Gligorijevic, Zeljko Djurovic, Stefano Di Gennaro, and Ivana Savic-Gajic
- Published
- 2015
- Full Text
- View/download PDF
45. Ultrafast Relaxation of Symmetry-Breaking Photo-Induced Atomic Forces
- Author
-
Eamonn Murray, Ivana Savic, Stephen Fahy, Felipe Murphy-Armando, José D. Querales-Flores, and Shane O'Mahony
- Subjects
Photon ,Phonon ,FOS: Physical sciences ,General Physics and Astronomy ,Electron ,Photon energy ,7. Clean energy ,01 natural sciences ,0103 physical sciences ,Boltzmann theory ,Symmetry breaking ,010306 general physics ,Photoexcitation ,Physics ,Condensed Matter - Materials Science ,Scattering ,Relaxation (NMR) ,Electron relaxation ,Materials Science (cond-mat.mtrl-sci) ,Electron-phonon coupling ,Ultrafast phenomena ,Elemental materials ,Optical absorption spectroscopy ,Photoinduced effect ,Density functional theory ,Phonons ,Atomic physics ,Semimetals - Abstract
We present a first-principles method for the calculation of the temperature-dependent relaxation of symmetry-breaking atomic driving forces in photoexcited systems. We calculate the phonon-assisted decay of the photoexcited force on the low-symmetry $E_g$ mode following absorption of an ultrafast pulse in the prototypical group-V semimetals, Bi, Sb and As. The force decay lifetimes for Bi and Sb are of the order of $10$ fs and in good agreement with recent experiments, demonstrating that electron-phonon scattering is the dominant mechanism relaxing the symmetry-breaking forces. Calculations for a range of absorbed photon energies suggest that larger amplitude, symmetry-breaking atomic motion may be induced by choosing a pump photon energy which maximises the product of the initial $E_g$ force and its lifetime. We also find that the high-symmetry $A_{1g}$ force undergoes a partial decay to a non-zero constant on similar timescales, which has not yet been measured in experiments. We observe that the imaginary part of the electron self-energy, averaged over the photoexcited carrier distribution, provides a reasonable estimate for the decay rate of symmetry-breaking forces., 7 pages, 9 figures
- Published
- 2019
46. Temperature effects on the electronic band structure of PbTe from first principles
- Author
-
Ivana Savic, Jiang Cao, José D. Querales-Flores, and Stephen Fahy
- Subjects
Electronic structure ,Materials science ,Physics and Astronomy (miscellaneous) ,Phonon ,Ab initio ,FOS: Physical sciences ,02 engineering and technology ,01 natural sciences ,Thermoelectric effects ,Condensed Matter::Materials Science ,First-principles calculations ,Electrical resistivity and conductivity ,0103 physical sciences ,Electrical conductivity ,General Materials Science ,Narrow band gap systems ,010306 general physics ,Electronic band structure ,Condensed Matter - Materials Science ,Condensed matter physics ,Materials Science (cond-mat.mtrl-sci) ,Electron-phonon coupling ,Thermoelectric systems ,021001 nanoscience & nanotechnology ,Density functional theory ,Condensed Matter::Strongly Correlated Electrons ,Crystalline systems ,Local-density approximation ,0210 nano-technology ,Maxima - Abstract
We report a fully {\it ab-initio} calculation of the temperature dependence of the electronic band structure of PbTe. We address two main features relevant for the thermoelectric figure of merit: the temperature variations of the direct gap and the difference in energies of the two topmost valence band maxima located at L and $\Sigma$. We account for the energy shift of the electronic states due to thermal expansion, as well as electron-phonon interaction computed using the non-adiabatic Allen-Heine-Cardona formalism within density functional perturbation theory and the local density approximation. We capture the increase of the direct gap with temperature in very good agreement with experiment. We also predict that the valence band maxima at L and $\Sigma$ become aligned at $\sim 600-700$ K. We find that both thermal expansion and electron-phonon interaction have a considerable effect on these temperature variations. The Fan-Migdal and Debye-Waller terms are of almost equal magnitude but have an opposite sign, and the delicate balance of these terms gives the correct band shifts. The electron-phonon induced renormalization of the direct gap is produced mostly by high-frequency optical phonons, while acoustic phonons are also responsible for the alignment of the valence band maxima at L and $\Sigma$., Comment: 12 pages, 12 figures
- Published
- 2019
47. Thermally induced band gap increase and high thermoelectric figure of merit of n-type PbTe
- Author
-
Ivana Savic, Stephen Fahy, José D. Querales-Flores, and Jiang Cao
- Subjects
Condensed Matter - Materials Science ,Thermoelectric transport ,Materials science ,Physics and Astronomy (miscellaneous) ,Condensed matter physics ,Band gap ,business.industry ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,02 engineering and technology ,Computational Physics (physics.comp-ph) ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Thermoelectric figure of merit ,Semiconductor ,Thermoelectric effect ,Figure of merit ,General Materials Science ,0210 nano-technology ,business ,Electronic band structure ,Physics - Computational Physics ,Energy (miscellaneous) - Abstract
Unlike in many other semiconductors, the band gap of PbTe increases considerably with temperature. We compute the thermoelectric transport properties of n-type PbTe from first principles including the temperature variation of the electronic band structure. The calculated temperature dependence of the thermoelectric quantities of PbTe is in good agreement with previous experiments when the temperature changes of the band structure are accounted for. We also calculate the optimum band gap values which would maximize the thermoelectric figure of merit of n-type PbTe at various temperatures. We show that the actual gap values in PbTe closely follow the optimum ones between 300 K and 900 K, resulting in the high figure of merit. Our results indicate that an appreciable increase of the band gap with temperature in direct narrow-gap semiconductors is very beneficial for achieving high thermoelectric performance., Comment: 10 pages, 9 figures
- Published
- 2019
- Full Text
- View/download PDF
48. Dominant electron-phonon scattering mechanisms in n-type PbTe from first principles
- Author
-
Jiang Cao, Ivana Savic, José D. Querales-Flores, Aoife R. Murphy, and Stephen Fahy
- Subjects
Materials science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed matter physics ,Phonon scattering ,Efficient thermoelectric materials ,Scattering ,Phonon ,Band gap ,Ab initio ,FOS: Physical sciences ,02 engineering and technology ,Soft modes ,021001 nanoscience & nanotechnology ,Thermoelectric materials ,01 natural sciences ,Boltzmann equation ,Condensed Matter::Materials Science ,n-type PbTe ,Boltzmann transport equation ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,0103 physical sciences ,010306 general physics ,0210 nano-technology - Abstract
We present an \emph{ab-initio} study that identifies the main electron-phonon scattering channels in $n$-type PbTe. We develop an electronic transport model based on the Boltzmann transport equation within the transport relaxation time approximation, fully parametrized from first-principles calculations that accurately describe the dispersion of the electronic bands near the band gap. Our computed electronic mobility as a function of temperature and carrier concentration is in good agreement with experiments. We show that longitudinal optical phonon scattering dominates electronic transport in $n$-type PbTe, while acoustic phonon scattering is relatively weak. We find that scattering due to soft transverse optical phonons is by far the weakest scattering mechanism, due to the symmetry-forbidden scattering between the conduction band minima and the zone center soft modes. Soft phonons thus play the key role in the high thermoelectric figure of merit of $n$-type PbTe: they do not degrade its electronic transport properties although they strongly suppress the lattice thermal conductivity. Our results suggest that materials like PbTe with soft modes that are weakly coupled with the electronic states relevant for transport may be promising candidates for efficient thermoelectric materials.
- Published
- 2018
49. Multiscale in modelling and validation for solar photovoltaics
- Author
-
Witold Jacak, Emmanuel Stratakis, J. C. Rimada, Hele Savin, Efrat Lifshitz, Mimoza Ristova, Mateja Hočevar, Radovan Kopecek, Blas Garrido, M. J. M. Gomes, Mircea Guina, Konstantinos Petridis, Alessio Gagliardi, David Fuertes Marrón, Ivana Capan, Jacky Even, Jaroslav Zadny, Pavel Tománek, V. Donchev, Stefan Birner, Janne Halme, Zoe Amin-Akhlaghi, Fatma Yuksel, Frederic Cortes Juan, Ahmed Neijm, Lejo k. Joseph, Søren Madsen, Abdurrahman Şengül, Marija Drev, Kristian Berland, Jose G. F. Coutinho, Knut Deppert, Diego Alonso-Álvarez, José Silva, Lucjan Jacak, Georg Pucker, Marco Califano, Violetta Gianneta, Nicholas J. Ekins-Daukes, Nikola Bednar, Urs Aeberhard, Shuxia Tao, Spyridon Kassavetis, Rasit Turan, Jelena Radovanović, Katarzyna Kluczyk, Ullrich Steiner, Ivana Savic, Maria E. Messing, Victor Neto, Stanko Tomić, Neil Beattie, Shengda Wang, Androula G. Nassiopoulou, Antonio Martí Vega, Denis Mencaraglia, M. Sendova-Vassileva, Ákos Nemcsics, Felipe Murphy Armando, Boukje Ehlen, Jean-François Guillemoles, Matthias Auf der Maur, James P. Connolly, Laurent Pedesseau, Clas Persson, Christin David, Lacramioara Popescu, Bostjan Cerne, N. Adamovic, Jean-Louis Lazzari, JM José Maria Ulloa, Urša Opara Krašovec, Irinela Chilibon, Jan Storch, Zoran Jakšić, Antti Tukiainen, Tareq Abu Hamed, Martin Loncaric, Laurentiu Fara, V. Kazukauskas, Jean-Paul Kleider, Javad Zarbakhsh, Dead Sea-Arava Science Center (DSASC), Institut für Energie- und Klimaforschung - Photovoltaik (IEK-5), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Imperial College London, ZAMSTEC − Science, Technology and Engineering Consulting, Università degli Studi di Roma Tor Vergata [Roma], University of Northumbria at Newcastle [United Kingdom], University of Leeds, Rudjer Boskovic Institute [Zagreb], Laboratoire Génie électrique et électronique de Paris (GeePs), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de València (UPV), Lund University [Lund], Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), University Politehnica of Bucharest [Romania] (UPB), Universidad Politécnica de Madrid (UPM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), National Center for Scientific Research 'Demokritos' (NCSR), Centre of Physics of the University of Minho (CFUM), Institut de Recherche et Développement sur l'Energie Photovoltaïque (IRDEP), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Tampere University of Technology [Tampere] (TUT), Aalto University, University of Ljubljana, Wroclaw University of Science and Technology, University of Belgrade [Belgrade], Aristotle University of Thessaloniki, Vilnius University [Vilnius], Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aarhus University [Aarhus], University College Cork (UCC), Óbuda University [Budapest], Universidade de Aveiro, University of Oslo (UiO), Technological Educational Institute of Crete, Fondazione Bruno Kessler [Trento, Italy] (FBK), University of Havana (Universidad de la Habana) (UH), Ss. Cyril and Methodius University in Skopje (UKIM), Tyndall National Institute [Cork], Zonguldak Bülent Ecevit University (BEU), Universidade de Taubaté (UNITAU), Cavendish Laboratory, University of Cambridge [UK] (CAM), Institute of Chemical Process Fundamentals of the ASCR, Czech Republic, Foundation for Research and Technology - Hellas (FORTH), Eindhoven University of Technology [Eindhoven] (TU/e), Brno University of Technology [Brno] (BUT), University of Salford, Middle East Technical University [Ankara] (METU), Gebze Technical University, Czech Academy of Sciences [Prague] (CAS), Carinthia University of Applied Sciences, MP1406, European Cooperation in Science and Technology, Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ss. Cyril and Methodius University in Skopje, Universidade do Minho, Dead Sea and Arava Science Center, Vienna University of Technology, Forschungszentrum Jülich, University of Rome Tor Vergata, Northumbria University, University of Oslo, nextnano GmbH, Rudjer Boskovic Institute, ZEL-EN d.o.o., National Institute of Research and Development for Optoelectronics, Université Paris-Saclay, Polytechnic University of Valencia, University of Aveiro, Madrid Institute for Advanced Studies in Nanoscience, Lund University, Sofia University St. Kliment Ohridski, Trimo Grp, Boukje.com Consulting, Centre National de la Recherche Scientifique (CNRS), University Politehnica of Bucharest, Technical University of Munich, University of Barcelona, Institute of Nanoscience and Nanotechnology, The University of Tokyo, Tampere University of Technology, Department of Applied Physics, Wrocław University of Science and Technology, University of Belgrade, ISC Konstanz eV, Vilnius University, Aix-Marseille Université, Technion-Israel Institute of Technology, Aarhus University, Polytechnic University of Madrid, University College Cork, Demokritos National Centre for Scientific Research, Silvaco Europe Ltd, Óbuda University, Hellenic Mediterranean University, Fondazione Bruno Kessler, University of Havana, SS Cyril and Methodius University in Skopje, Department of Electronics and Nanoengineering, Bulgarian Academy of Sciences, Bulent Ecevit University, Adolphe Merkle Institute, Czech Academy of Sciences, Foundation for Research and Technology - Hellas, Eindhoven University of Technology, Brno University of Technology, Middle East Technical University, Aalto-yliopisto, Zonguldak Bülent Ecevit Üniversitesi, Center for Computational Energy Research, and Computational Materials Physics
- Subjects
Nano structures ,lcsh:TJ807-830 ,Modelling and validation ,02 engineering and technology ,semiconductors ,01 natural sciences ,7. Clean energy ,Settore ING-INF/01 - Elettronica ,Environmental footprints ,law.invention ,[SPI.MAT]Engineering Sciences [physics]/Materials ,Semiconductor materials ,WAVE BASIS-SET ,law ,Photovoltaics ,CARRIER MULTIPLICATION ,Multi-scale simulation ,multi-scale modelling ,Telecomunicaciones ,COLLOIDAL QUANTUM DOTS ,device simulation ,NANOMETER-SCALE ,Photovoltaic cells ,Physics ,Photovoltaic system ,Nanostructured materials ,Renewable energy resources ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Multiscale modeling ,Electronic, Optical and Magnetic Materials ,Characterization (materials science) ,Renewable energy ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,ELECTRONIC-STRUCTURE ,SDG 12 – Verantwoordelijke consumptie en productie ,Energías Renovables ,Physical Sciences ,TIGHT-BINDING ,Systems engineering ,Electrónica ,0210 nano-technology ,NEAR-FIELD ,solar cells ,third generation photovoltaics ,nano structures ,Solar cells ,J500 ,Ciências Naturais::Ciências Físicas ,F300 ,H600 ,Third generation photovoltaics ,ta221 ,Renewable energy source ,Ciências Físicas [Ciências Naturais] ,lcsh:Renewable energy sources ,GREENS-FUNCTION ,Solar power generation ,Different length scale ,Physics, Applied ,OPTICAL-RESPONSE ,0103 physical sciences ,Solar cell ,SDG 7 - Affordable and Clean Energy ,Electrical and Electronic Engineering ,010306 general physics ,Device simulations ,Ecological footprint ,Science & Technology ,ta114 ,Renewable Energy, Sustainability and the Environment ,business.industry ,TOTAL-ENERGY CALCULATIONS ,[SPI.NRJ]Engineering Sciences [physics]/Electric power ,Environmental technology ,Nanostructures ,Multiple exciton generation ,13. Climate action ,Conversion efficiency ,business ,SDG 12 - Responsible Consumption and Production ,SDG 7 – Betaalbare en schone energie - Abstract
Photovoltaics is amongst the most important technologies for renewable energy sources, and plays a key role in the development of a society with a smaller environmental footprint. Key parameters for solar cells are their energy conversion efficiency, their operating lifetime, and the cost of the energy obtained from a photovoltaic system compared to other sources. The optimization of these aspects involves the exploitation of new materials and development of novel solar cell concepts and designs. Both theoretical modeling and characterization of such devices require a comprehensive view including all scales from the atomic to the macroscopic and industrial scale. The different length scales of the electronic and optical degrees of freedoms specifically lead to an intrinsic need for multiscale simulation, which is accentuated in many advanced photovoltaics concepts including nanostructured regions. Therefore, multiscale modeling has found particular interest in the photovoltaics community, as a tool to advance the field beyond its current limits. In this article, we review the field of multiscale techniques applied to photovoltaics, and we discuss opportunities and remaining challenges. © T. Abu Hamed et al., published by EDP Sciences, 2018., European Cooperation in Science and Technology: MP1406, The authors are grateful for the financial support by the COST Action MP1406 “MultiscaleSolar.”
- Published
- 2018
50. SDG7 - Ensure Access to Affordable, Reliable, Sustainable, and Modern Energy
- Author
-
Godwell Nhamo, Charles Nhemachena, Senia Nhamo, Vuyo Mjimba, Ivana Savić, Godwell Nhamo, Charles Nhemachena, Senia Nhamo, Vuyo Mjimba, and Ivana Savić
- Subjects
- Energy security, Renewable energy sources
- Abstract
SDG7 aims to'ensure access to affordable, reliable, sustainable and modern energy for all.'Meeting the demands of the 2030 agenda will be a unique challenge. National priorities and policy action need to be strengthened in order to fulfil the ambitious energy targets which SDG7 envisions. This book examines SDG7 and its implications for how energy operates as a driver of change for jobs, security, climate change, food production and increasing incomes. It provides a succinct overview of how SDG7 visualizes a world in which energy is universally accessible, increasingly efficient and renewable in order to create sustainable, inclusive and resilient communities. The key challenges such as public and private investment, regulatory frameworks and evolving business models are also considered so that a path forward towards the achievement of the goal and the transformation of global energy systems might become clear. Concise Guides to the United Nations Sustainable Development Goals comprises 17 short books, each examining one of the UN Sustainable Development Goals. The series provides an integrated assessment of the SDGs from economic, legal, social, environmental and cultural perspectives.
- Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.