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Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study.

For a nonabelian group G, the non-commuting graph Γ of G is defined as the graph with vertex-set G-Z(G), where Z(G) is the center of G, and two distinct vertices of Γ are adjacent if they do not commute in G. In this paper, we investigate the detour index, eccentric connectivity and total eccentricity polynomials of the non-commuting graph on D2n. We also find the mean distance of the non-commuting graph on D2n.

This review brings an overview of the Slovak regulations concerning occupational safety and health at work (OSH) primarily considering the parameter of physical load. In addition to regulations, this article focuses on particular requirements at workplaces with an increased physical load and describes the permissible values of the physical load (see tables). Attention is given to assessing the working posture and handling of loads. The main purpose of the evaluation is to determine the parameters of physical load, which is the first important step in the process of health risk assessment. Based on the physical load assessment and the categorization of tasks for the physical load factor in the Slovak Republic, further steps and measures should be taken to improve working conditions, to reduce the workload, number of health problems, fatigue, and ultimately to prevent accidents at work and work-related musculoskeletal diseases.

Operation of special equipment is possible in crisis situations. It is because special equipment is designed for operation in non-standard often extreme conditions and situation, it is available, it has a high degree of crossing capability and it is able to provide basic living conditions even in field, e.g. provision of power for hospital, transportation of wounded and injured persons, supplies, medical care in field conditions, delivery of potable and utility water etc. The authors in the paper deal with a possibility to provide electric energy through advanced renewable sources, especially in meeting tasks in areas with no public mains, possible supplies of potable and non-potable water, embedding such assets into mobile systems. The authors in publication summarize results of research within the „Use of renewable sources of energy in practice project“. System of modeling and computer-aided simulation of renewable sources of energy has been proposed within this project. Application of a system for designing of power systems in logistic containers is expected. The knowledge on power balance of logistic containers operated by the SR Armed Forces in missions abroad is summarized in the last chapter of the paper. Experiences with operating the equipment in crisis and extreme conditions have proved a possibility to export and deploy machines and weaponry equipment of the SR Armed Forces into extreme climatic conditions, e.g. out of European conditions etc.

This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective International T-cell Project. We analyzed data from 1020 patients with newly diagnosed disease, enrolled between September 2006 and December 2015. Out of 937 patients who received first-line treatment, 436 (47%) were identified as refractory and 197 (21%) as relapsed. Median time from the end of treatment to relapse was 8 months (range 2-73). Overall, 75 patients (8%) were consolidated with bone marrow transplantation, including 12 refractory and 22 relapsed patients. After a median follow up of 38 months (range 1-96 months) from documentation of refractory/relapsed disease, 440 patients had died. The median overall survival (OS) was 5.8 months; 3-year overall survival rates were 21% and 28% for refractory and relapsed patients, respectively (P

The article evaluates the issue of work at heights in industry and reports statistics on fatal accidents at work, the source of which is a fall from above. It also deals with the assessment of the state of personal protective equipment already in use - for example, safety and working ropes and other accessories contaminated with facade paints, lyes, acids or mineral oils and their misuse and dangerous use. The state of the assessed personal protective equipment used was assessed in a test facility on test machines, where the safety of these devices was verified under certain conditions. The article also mentions the issue of inadequate training and training of high-level workers and the lack of training centers that carry out such training.

Background: Women in neurosurgery often have to delay pregnancy and child-rearing because the optimum time for having children overlap with an intense period of training and/or career advancement. The purpose of the study is to investigate the personal experiences of women neurosurgeons and understand the complex interaction between pursuing a career and embracing motherhood., Methods: We employed anonymized, semi-structured interviews with women actively involved in the field of neurosurgery. Person-to-person interviews were performed online via video call. Responses were grouped and analyzed with thematic analysis. We identified recurring patterns and insights in the interview responses., Results: We included twenty-one women neurosurgeons, at various career levels. Thematic analysis revealed diverse perspectives. More than half favored a delayed pregnancy announcement. The majority perceived a workplace, social stigma attached to pregnancy. Although most of them reported adequate support from their colleagues, several explained that the support was theoretical rather than practical. Many interviewees expressed their fears about losing their surgical skills, while 57.2% had concerns regarding their physical abilities during or after pregnancy. All but one felt that female neurosurgeons should not postpone or sacrifice motherhood for their career. However, alternative paths within neurosurgery could be an option., Conclusions: Finding a way to combine a career in neurosurgery with pregnancy can be very challenging and may be vital to keep attracting quality professionals to the field. Efforts should be made to maintain the balance between career and home and to facilitate greater flexibility at the workplace for women who are pregnant and/or child-rearing., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Neurosurgeons may resort to caffeine, alcohol, and various drugs to maintain peak performance as they grapple with work demands and escalated stress. The prevalence of this controversial strategy remains largely unexplored., Methods: An anonymous survey of 23 questions formulated by our research group was distributed through personal contacts and neurosurgical societies. Inquiries revolved around the use of medications and other substances for job-related reasons. Data were analyzed via regression and descriptive statistics in python., Results: In total, 215 neurosurgeons (43 residents) were included, with 213 disclosing their gender (94 females). Out of all, 9.3% were <30, 38.1% were 30-39, 44.6% were 40-59, and 7.9% were >60 years old. Most (70.7%) practiced in Europe, 18.6% in Asia, 6.5% in North and South America, and the rest in Africa or Australia. While 132 participants stated they consume caffeine to manage challenging schedules, drugs for cognitive and mood enhancement were utilized by 18 and 35 respectively. Alcohol was employed for stress relief by 28 with 4 reporting as heavy drinkers. Drugs posed a solution to sleep disorders for 82, and helped 8 others in strengthening their hand dexterity. Notably, 12 of those claiming drug use initiated it in medical school. Exercise, self-care activities, and relational support were the main alternatives sought. Ultimately, most responders recommended extending mental health assistance and raising awareness about drug use., Conclusions: Reflecting on our results on job-associated drug use by neurosurgeons, we propose the judicious use of pharmacological or nonpharmacological adjuncts, alongside the prioritization of neurosurgeons' well-being., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Introduction: Neurosurgery is one of the most demanding medical specialties. For neurosurgeons, balancing professional activity with personal life can be challenging., Research Question: To evaluate gender differences in contribution of neurosurgeons in the household and child-rearing, as well as their impact on personal life and career., Material and Methods: An anonymous, electronic, 59-item web-based survey was administered to National Neurosurgical Societies of Europe, and European Member Societies of the European Association of Neurosurgical Societies (June-October 2021)., Results: A total of 205 European neurosurgeons (87 females and 118 males, mean age 40.7) are included in our survey. In neurosurgery, females are significantly more likely to be alone (37.9%), while males are significantly more likely to have children (66.9%). In terms of household efforts, females spend more time than males on the same tasks. Most participants (71.2%) view gender issues as a disadvantage in career pursuing. Women feel less accepted (54.3%) and having fewer opportunities (58.6%), while men believe that pregnancy/child-rearing (65.8%) and having many roles (51.3%) are the main obstacles. Both genders (77.6%) favor more convenient working conditions for young parents. Discussion and Conclusion. In our study we found that, women neurosurgeons take more responsibilities at home, especially in the child-rearing years. Female neurosurgeons are more likely to live alone or stay childless more often compared to their male colleagues. Supportive facilities, flexible programs, universal life policies and presumably curbing of the social stereotypes are of importance to overcome gender inequities that women are still facing in neurosurgery., (© 2022 The Authors.)