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Your search keyword '"Ivančinová, Jana"' showing total 3 results
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3 results on '"Ivančinová, Jana"'

2. High grade serous ovarian carcinoma: molecular background and platinum-based chemotherapy challenges

Author

Ivančinová, Jana, Heneberg, Petr, and Brábek, Jan

Subjects
nádor, ovarian cancer, chemotherapy resistance, tumor, disease relapse, rezistence k chemoterapii, relaps onemocnění, metabolismus, metabolism, karcinom ovaria
Abstract

Ovarian carcinoma (O.C.) represent a group of various disease entities derived from ovaries. The most common malignant gynaecological cancer is high-grade serous ovarian carcinoma (HGSOC). HGSOC is associated with a high mortality rate due to its aggressive behaviour and insufficient early-stage detection. The survival rate has not been significantly improved since 1970s. The most effective treatment of HGSOC patients is by cytoreductive surgery (for early stages I/II) and followed by platinum-based chemotherapy (HGSOC presented in advanced stage III/IV) combined with taxane or potentially with PARP inhibitors (for BRCA1/2 mutation carriers). Multiple factors affect the patient's outcome and prognosis. Chemoresistance, molecular mutational patterns, stage at presentation of HGSOC are one of the clinical challenges contributing to common relapses even though patients often initially respond well to the HGSOC chemotherapy. This thesis overviews the fundamental biology of HGSOC, the major obstacles in clinical management and its improvements by implementing of multitherapy approaches. Key words: CA-125; platinum−based chemotherapy treatment; homologous recombination deficiency; ovarian carcinoma; resistance; Tp53; mortality; survival rate

Published
2022

3. Mathematical Modeling of an Oil Refinery WWTP.

Author

Derco, Ján, Černochová, Lenka, Ivančinová, Jana, Lalai, Antonio, and Pijáková, Ivana

Subjects
*SEWAGE disposal plants, *PETROLEUM refineries, *MATHEMATICAL models, *ACTIVATED sludge process, *CALIBRATION, *PERFORMANCE evaluation, *SEWAGE aeration
Abstract

Activated Sludge Model No. 1 (ASM1) was used in the modeling of an activated sludge system treating effluents from an oil refinery. The measurements of the diurnal variation in wastewater flow and composition at the wastewater treatment plant inlet and outlet were carried out. The calibrated model predicting the influence of changes in the wastewater composition and the operational parameters on the effluent wastewater quality and the related operational costs is available. A calibration technique based on the heuristic method was applied. The model was used to analyze the influence of changes in wastewater flow and composition as well as different aeration systems on the process performance. The results of dynamic simulations indicate that the verified dynamic mathematical model is a useful supporting tool for optimizing operational parameter values and operational costs. The presented results are for illustration purposes only and are not intended as instructions for the operation of a wastewater treatment plant. [ABSTRACT FROM AUTHOR]

Published
2012

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