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1. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Laura Herrera-Hidalgo, Patricia Muñoz, Ana Álvarez-Uría, David Alonso-Menchén, Rafael Luque-Marquez, Encarnación Gutiérrez-Carretero, María Del Carmen Fariñas, Jose Maria Miró, Miguel Angel Goenaga, Luis Eduardo López-Cortés, Basilio Angulo-Lara, Lucia Boix-Palop, Arístides de Alarcón, Fernando Fernández Sánchez, José Mª García de Lomas, Gabriel Rosas, Javier de la Torre Lima, Elena Bereciartua, María José Blanco Vidal, Roberto Blanco, María Victoria Boado, Marta Campaña Lázaro, Alejandro Crespo, Laura Guio Carrión, Mikel Del Álamo Martínez de Lagos, Gorane Euba Ugarte, Ane Josune Goikoetxea, Marta Ibarrola Hierro, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Miguel Montejo, Javier Nieto, David Rodrigo, Regino Rodríguez, Yolanda Vitoria, Roberto Voces, Mª Victoria García López, Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ignacio Álvarez Rodríguez, Harkaitz Azkune Galparsoro, Elisa Berritu Boronat, Mª Jesús Bustinduy Odriozola, Cristina del Bosque Martín, Tomás Echeverría, Alberto Eizaguirre Yarza, Ana Fuentes, Miguel Ángel Goenaga, Muskilda Goyeneche del Río, Ángela Granda Bauza, José Antonio Iribarren, Xabier Kortajarena Urkola, José Ignacio Pérez-Moreiras López, Ainhoa Rengel Jiménez, Karlos Reviejo, Alberto Sáez Berbejillo, Elou Sánchez Haza, Rosa Sebastián Alda, Itziar Solla Ruiz, Irati Unamuno Ugartemendia, Diego Vicente Anza, Iñaki Villanueva Benito, Mar Zabalo Arrieta, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Alberto Bouzas, Brais Castelo, José Cuenca, Laura Gutiérrez, Lucía Ramos, María Rodríguez Mayo, Joaquín Manuel Serrano, Dolores Sousa Regueiro, Francisco Javier Martínez, Mª del Mar Alonso, Beatriz Castro, Teresa Delgado Melian, Javier Fernández Sarabia, Dácil García Rosado, Julia González González, Juan Lacalzada, Lissete Lorenzo de la Peña, Alina Pérez Ramírez, Pablo Prada Arrondo, Fermín Rodríguez Moreno, Antonio Plata Ciezar, José Mª Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Juan Ambrosioni, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Guillermo Cuervo, Carlos Falces, Mariana J Fernández-Pittol, Guillermina Fita, David Fuster, Cristina García de la Mària, Delia García-Pares, Marta Hernández-Meneses, Jaume Llopis Pérez, Francesc Marco, José M. Miró, Asunción Moreno, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Juan M. Pericás, José L. Pomar, José Ramírez, Mercè Roque, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, José M. Tolosana, Bárbara Vidal, Jordi Vila, Iván Adán, David Alonso, Juan Carlos Alonso, Javier Bermejo, Emilio Bouza, Gregorio Cuerpo Caballero, Antonia Delgado Montero, Agustín Estévez, Ramón Fortuny Ribas, Esther Gargallo, Mª Eugenia García Leoni, Ana González Mansilla, Francisco Javier González Moraga, Víctor González Ramallo, Martha Kestler Hernández, Amaia Mari Hualde, Marina Machado, Mercedes Marín, Manuel Martínez-Sellés, Rosa Melero, Diego Monzón, María Olmedo, Álvaro Pedraz, Blanca Pinilla, Ángel Pinto, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Eduardo Sánchez-Pérez, Antonio Segado, Neera Toledo, Maricela Valerio, Pilar Vázquez, Eduardo Verde Moreno, Sofía de la Villa, Isabel Antorrena, Belén Loeches, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Sandra Rosillo, Jesús Agüero Balbín, Cristina Amado Fernández, Carlos Armiñanzas Castillo, Francisco Arnaiz de las Revillas, Manuel Cobo Belaustegui, María Carmen Fariñas, Concepción Fariñas-Álvarez, Marta Fernández Sampedro, Iván García, Claudia González Rico, Laura Gutiérrez-Fernández, Manuel Gutiérrez-Cuadra, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Jorge Calderón Parra, Marta Cobo, Fernando Domínguez, Pablo García Pavía, Ana Fernández Cruz, Antonio Ramos-Martínez, Isabel Sánchez Romero, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Navas, Enrique Oliva, Alejandro del Río, Jorge Rodríguez-Roda Stuart, Soledad Ruiz, Carmen Hidalgo Tenorio, Sergio Sequera, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Juan Gálvez Acebal, Irene Méndez, Isabel Morales, José Antonio Lepe, José López-Haldón, Rafael Luque-Márquez, Guillermo Marín, Antonio Ortiz-Carrellán, Eladio Sánchez-Domínguez, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Estíbaliz Corral Armas, Lara García-Álvarez, José Antonio Oteo, Antonio Barros Membrilla, Antonino Ginel Iglesias, Sara Grillo, Rubén Leta Petracca, Joaquín López-Contreras, María Alba Rivera Martínez, M. Álvarez, A.L. Fernández, Amparo Martínez, A. Prieto, Benito Regueiro, E. Tijeira, Marino Vega, Amaia Aguirre Quiñonero, Ángela Alonso Miñambres, Juan Carlos Gainzarain Arana, Sara González de Alaiza Ortega, Miguel Ángel Morán Rodríguez, Anai Moreno Rodríguez, Zuriñe Ortiz de Zárate, José Joaquín Portu Zapirain, Ester Sáez de Adana Arroniz, Daisy Carolina Sorto Sánchez, Sánchez-Porto Antonio, Úbeda Iglesias Alejandro, José Mª Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, Mª Antonia Sepúlveda, Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Ivan Keituqwa Yañez, Julián Navarro Martínez, Ana Peláez Ballesta, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Mª Cruz Pérez Seco, Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Mª Pilar Palacián Ruiz, Juan Carlos Porres, Begoña Alcaraz Vidal, María Jesús Del Amor Espín, Francisco Buendía, Roberto Jiménez Sánchez, Rosario Mármol, Francisco Martínez, Antonio Meseguer, Beatriz Pérez, Leticia Risco, Zoser Saura, Vanina Silva, Mª Belén Villmarín, Mª Ángels Ribas Blanco, Enrique Ruiz de Gopegui Bordes, Laura Vidal Bonet, Miquel Vives Borràs, Mª Carmen Bellón Munera, Elena Escribano Garaizabal, Antonia Tercero Martínez, Juan Carlos Segura Luque, Cristina Badía, Lucía Boix Palop, Mariona Xercavins, Sónia Ibars, Xerach Bosch, Eloy Gómez Nebreda, Ibalia Horcajada Herrera, Irene Menduiña Gallego, Imanol Pulido, Héctor Marrero Santiago, Isabel de Miguel Martínez, Elena Pisos Álamo, Daniel San Román Sánchez, Jorge Boan Pérez, Eva Mª Aguilar Blanco, Mercedes Catalán González, María Angélica Corres Peiretti, Andrea Eixerés Esteve, Laura Domínguez Pérez, Santiago de Cossío Tejido, Francisco Galván Román, José Antonio García Robles, Francisco López Medrano, Mª Jesús López Gude, Mª Ángeles Orellana Miguel, Patrick Pilkington, Yolanda Revilla Ostalaza, Juan Ruiz Morales, Sebastián Ruiz Solís, Ana Sabín Collado, Marcos Sánchez Fernández, Javier Solera Rallo, Jorge Solís Martín, Francesc Escrihuela-Vidal, Jordi Carratalà, Inmaculada Grau, Carmen Ardanuy, Dámaris Berbel, José Carlos Sánchez Salado, Oriol Alegre, Alejandro Ruiz Majoral, Fabrizio Sbraga, Arnau Blasco, Laura Gracia Sánchez, Iván Sánchez-Rodríguez, Gonzalo Aldamiz, Beatriz Álvarez, Marina Bernal Palacios, Alfonso Cabello Úbeda, Ricardo Fernández Roblas, Rafael Hernández, Victoria Andrea Hortigüela Martín, Andrea Kallmeyer, Cristina Landaeta Kancev, Marta Martín, Miguel Morante Ruiz, Miguel Ángel Navas Lobato, Ana María Pello, Laura Prieto, Marta Tomás Mallebrera, Laura Varela, Mireia de la Peña Triguero, Ruth Esther Figueroa Cerón, Lara Ruiz Gómez, Mireia Ble, Juan Pablo Horcajada Gallego, Antonio José Ginel, Inmaculada López, Alexandra Mas, Antoni Mestres, Lluís Molina, Ramón Serrat, Núria Ribas, Francisca Sánchez, Ana Silverio, Marina Suárez, Luisa Sorlí, Lluís Recasens, Manuel Taurón, María Fernández Regueras, María Ángeles Mantecón Vallejo, José Ángel Pérez Rivera, Nuria Sánchez Mata, Antonia Calvo Cano, Miguel Fajardo Olivares, María Victoria Millán Núñez, and Agustín Muñoz Sanz

Subjects
Infective endocarditis, Methicillin-susceptible Staphylococcus aureus, Cefazolin, Antistaphylococcal penicillin, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P

Published
2023
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2. Differences between patient-driven adherence to vitamin K antagonists and direct oral anticoagulants. Do few missed doses matter? ACO-MEMS Study

Author

Francisco De La Cuesta-Arzamendi, Ramón Querejeta-Iraola, Emilio Paredes-Galán, Itziar Solla-Ruiz, Garazi Oria-González, Iñaki Villanueva-Benito, and Nahikari Salterain-González

Subjects
Male, medicine.medical_specialty, Vitamin K, Time in therapeutic range, 030204 cardiovascular system & hematology, Vitamin k, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, medicine, Humans, Clinical significance, Prospective Studies, Pharmacy refill, Aged, business.industry, Anticoagulants, Atrial fibrillation, Hematology, medicine.disease, Highly sensitive, 030220 oncology & carcinogenesis, Oral anticoagulant, Female, business, Cohort study
Abstract

Introduction Lack of INR controls might affect the adherence to direct oral anticoagulants (DOAC). The vast majority of studies that addresses adherence to anticoagulants are retrospective and based on pharmacy refill data. Our aim was to compare the adherence between vitamin K antagonists (VKA) and DOAC and to analyze the clinical relevance of non-adherence. Materials and methods A prospective two-arm observational cohort study was performed in two Spanish public hospitals. Adherence was assessed by Medication Event Monitoring System. Relationship between adherence and events during follow-up and time in therapeutic range (TTR) in the VKA group were analyzed. Results 257 patients were included (132 DOAC and 125 VKA). Monitoring time was 120 days (101−133). Patients in VKA group showed higher taking adherence (97.9% vs. 95.8%) and less non-adherent patients of >5% and >10% of the doses, without differences in >20% of the doses. Taking adherence was strongly associated with TTR (AUC: 0.89, CI 95%: 0.81–0.97 of TTR for detection of non-adherent patients of >10% of doses). During a follow-up of 1.8 years (1.6–2) non-adherent patients of >5% of doses presented more thromboembolic events (HR 6.1, CI95% 1.3–28.1). Conclusions Although adherence to oral anticoagulant therapy was excellent, it was higher to VKA than to DOAC. Time in therapeutic range was highly sensitive to few missed doses of AVK. Non-adherence of >5% of prescribed doses had high clinical relevance.

Published
2019

3. Association of Left Ventricular Systolic Dysfunction Among Carriers of Truncating Variants in Filamin C With Frequent Ventricular Arrhythmia and End-stage Heart Failure

Author

Jens Mogensen, Ainhoa Robles Mezcua, Larraitz Gaztañaga Arantzamendi, Itziar Solla Ruiz, Diego Rangel-Sousa, Javier Limeres Freire, Francisco Bermúdez-Jiménez, Juan Jiménez-Jáimez, Jorge Alvarez-Rubio, Philippe Charron, Raquel Yotti, María Luisa Peña-Peña, Mohammed M Akhtar, José Rodríguez-Palomares, Estibaliz Zamarreño Golvano, Sofía Cuenca, Zofia T. Bilińska, Xabier Arana Achaga, Flavie Ader, Marina Navarro Peñalver, María Alejandra Restrepo-Córdoba, Vincent Climent, Mathias Gautel, Soren K Nielsen, Massimiliano Lorenzini, Esther Zorio, Menelaos Pavlou, Torsten Bloch Rasmussen, Roberto Barriales-Villa, Pilar Molina, Julián Palomino-Doza, José M. Larrañaga-Moreira, Perry M. Elliott, Diego Segura-Rodríguez, María I. García-Álvarez, Hans Eiskjær, Constantinos O'Mahony, María Sabater-Molina, Martin Ortiz-Genga, Juan Pablo Ochoa, José Manuel García-Pinilla, Tomás Ripoll-Vera, Grażyna Truszkowska, Pablo García-Pavía, University College of London [London] (UCL), Ciencia Animal, Universitat Politècnica de València (UPV), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Adult, Cardiomyopathy, Dilated, Male, medicine.medical_specialty, Filamins, Cardiomyopathy, 030204 cardiovascular system & hematology, Sudden cardiac death, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Cardiac magnetic resonance imaging, Internal medicine, medicine, Humans, Connectin, 030212 general & internal medicine, Heart Failure, Ejection fraction, medicine.diagnostic_test, business.industry, Hazard ratio, Correction, Stroke Volume, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Middle Aged, medicine.disease, Defibrillators, Implantable, 3. Good health, Death, Sudden, Cardiac, Codon, Nonsense, Heart failure, Mutation, Cohort, Tachycardia, Ventricular, Cardiology, Heart Transplantation, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Importance: Truncating variants in the gene encoding filamin C (FLNCtv) are associated with arrhythmogenic and dilated cardiomyopathies with a reportedly high risk of ventricular arrhythmia.Objective: To determine the frequency of and risk factors associated with adverse events among FLNCtv carriers compared with individuals carrying TTN truncating variants (TTNtv).Design, Setting, and Participants: This cohort study recruited 167 consecutive FLNCtv carriers and a control cohort of 244 patients with TTNtv matched for left ventricular ejection fraction (LVEF) from 19 European cardiomyopathy referral units between 1990 and 2018. Data analyses were conducted between June and October, 2020.Main Outcomes and Measures: The primary end point was a composite of malignant ventricular arrhythmia (MVA) (sudden cardiac death, aborted sudden cardiac death, appropriate implantable cardioverter-defibrillator shock, and sustained ventricular tachycardia) and end-stage heart failure (heart transplant or mortality associated with end-stage heart failure). The secondary end point comprised MVA events only.Results: In total, 167 patients with FLNCtv were studied (55 probands [33%]; 89 men [53%]; mean [SD] age at baseline evaluation, 43 [18] years). For a median follow-up of 20 months (interquartile range, 7-60 months), 29 patients (17.4%) reached the primary end point (19 patients with MVA and 10 patients with end-stage heart failure). Eight (44%) arrhythmic events occurred among individuals with baseline mild to moderate left ventricular systolic dysfunction (LVSD) (LVEF = 36%-49%). Univariable risk factors associated with the primary end point included proband status, LVEF decrement per 10%, ventricular ectopy (≥500 in 24 hours) and myocardial fibrosis detected on cardiac magnetic resonance imaging. The LVEF decrement (hazard ratio [HR] per 10%, 1.83 [95% CI, 1.30-2.57]; P Conclusions and Relevance: The high frequency of MVA among patients with FLNCtv with mild to moderate LVSD suggests that higher LVEF values than those currently recommended should be considered for prophylactic implantable cardioverter-defibrillator therapy in FLNCtv carriers.

Published
2021

6. Impacto pronóstico del abordaje intervencionista en el paciente muy anciano con síndrome coronario agudo sin elevación del segmento ST

Author

Andrés Íñiguez-Romo, Emilio Paredes-Galán, Francisco Calvo-Iglesias, Óscar Díaz-Castro, Itziar Solla-Ruiz, Iñaki Villanueva-Benito, and José Antonio Baz-Alonso

Subjects
business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract

Resumen Introduccion y objetivos En el sindrome coronario agudo sin elevacion del segmento ST de riesgo intermedio o alto, las guias de actuacion clinica recomiendan la realizacion de coronariografia con intencion de revascularizar. Sin embargo, para los pacientes muy ancianos la evidencia que avala esta recomendacion es muy escasa. Metodos Analizamos retrospectivamente a todos los pacientes con sindrome coronario agudo sin elevacion del segmento ST y edad ≥ 85 anos ingresados en un unico centro entre 2004 y 2009. Mediante propensity score, emparejamos 1:1 a los pacientes con abordaje intervencionista con aquellos en que se decidio manejo conservador. Se comparo la supervivencia y la supervivencia libre de eventos isquemicos. Resultados Se incluyo a 228 pacientes consecutivos (media de edad 88 [intervalo, 85-101] anos). Se decidio abordaje intervencionista en 100 pacientes (128 con manejo conservador). Los enviados a abordaje intervencionista eran mas jovenes y mas frecuentemente varones y tenian menos comorbilidad, menos demencia y menos frecuentemente elevacion de troponina. Se emparejo a 63 pacientes del grupo de abordaje intervencionista con 63 del grupo de manejo conservador mediante propensity score. En el seguimiento a 3 anos de los pacientes emparejados, el grupo de abordaje intervencionista presento mayor supervivencia (log rank test = 4,24; p = 0,039) y mayor supervivencia libre de eventos isquemicos (log rank test = 8,63; p = 0,003). En la poblacion total, ajustando por quintiles de propensity score, el abordaje intervencionista se relaciono con mayor supervivencia (hazard ratio = 0,52; intervalo de confianza del 95%, 0,32-0,85) y mayor supervivencia libre de eventos isquemicos (hazard ratio = 0,48; intervalo de confianza del 95%, 0,32-0,74). Conclusiones Casi todos los pacientes muy ancianos ingresados por sindrome coronario agudo sin elevacion del segmento ST estan en riesgo intermedio-alto. En estos pacientes, el abordaje intervencionista se relaciona con mayor supervivencia y mayor supervivencia libre de eventos isquemicos.

Published
2011

7. [Prognostic impact of interventional approach in non-ST segment elevation acute coronary syndrome in very elderly patients]

Author

Andrés Íñiguez-Romo, Francisco Calvo-Iglesias, Iñaki Villanueva-Benito, Itziar Solla-Ruiz, Emilio Paredes-Galán, Óscar Díaz-Castro, and José Antonio Baz-Alonso

Subjects
Male, medicine.medical_specialty, Acute coronary syndrome, Survival, Population, Coronary Angiography, Coronary artery disease, Electrocardiography, Sex Factors, Internal medicine, medicine, Odds Ratio, ST segment, Humans, Acute Coronary Syndrome, education, Propensity Score, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, education.field_of_study, Interventional cardiology, business.industry, Hazard ratio, Troponin I, General Medicine, medicine.disease, Prognosis, Comorbidity, Confidence interval, Cardiology, Female, business, Cognition Disorders
Abstract

Acute Coronary Syndrome Coronary artery disease Coronary angiography Interventional cardiology The Elderly Geriatric medicine Prognosis Survival A B S T R A C T Introduction and objectives: In moderate or high risk non-ST segment elevation acute coronary syndrome, clinical practice guidelines recommend a coronary angiography with intent to revascularize. However, evidence to support this recommendation in very elderly patients is poor. Methods: All patients over 85 years old admitted to our hospital between 2004 and 2009 with a diagnosis of non-ST segment elevation acute coronary syndrome were retrospectively included. Using a propensity score, patients undergoing the interventional approach and those undergoing conservative management were matched and compared for survival and survival without ischemic events. Results: We included 228 consecutive patients with a mean age of 88 years (range: 85 to 101). Those in the interventional approach group (n = 100) were younger, with a higher proportion of males and less comorbidity, less cognitive impairment and lower troponin I levels compared with patients in the conservative management group (n = 128). We matched 63 patients from the interventional approach group and 63 from the conservative management group using propensity score. In the matched patients, the interventional approach group exhibited better survival (log rank 4.24; P = .039) and better survival free of ischemic events (log rank 8.63; P = .003) at the 3-year follow-up. In the whole population, adjusted for propensity score quintiles, the interventional approach group had lower mortality (hazard ratio 0.52; 95% confidence interval: 0.32-0.85) and a better survival free of ischemic events (hazard ratio 0.48; 95% confidence interval: 0.32-0.74). Conclusions: Nearly all the very elderly patients admitted with non-ST segment elevation acute coronary syndrome were of moderate or high risk. In these patients, the interventional approach was associated with overall better survival and better survival free of ischemic events.

Published
2010

9. Hemoptysis as the presenting symptom in cardiac sarcoma

Author

M. Begoña Iglesias-Rodriguez, Subhi R. Yas, Iñaki Villanueva-Benito, Miguel A. Pereira-Loureiro, Vanesa Asorey-Veiga, and Itziar Solla-Ruiz

Subjects
Adult, medicine.medical_specialty, Hemoptysis, lcsh:Diseases of the circulatory (Cardiovascular) system, business.industry, Sarcoma, Heart Neoplasms, Text mining, lcsh:RC666-701, medicine, General Earth and Planetary Sciences, Humans, Female, Radiology, Cardiology and Cardiovascular Medicine, business, Cardiac sarcoma, General Environmental Science
Published
2012

11. Atrial flutter with exercise-induced 1:1 atrioventricular conduction

Author

Itziar Solla-Ruiz, José Luis Escribano-Arias, Mónica Pardo-Fresno, and Iñaki Villanueva-Benito

Subjects
Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, business.industry, Atrioventricular conduction, P wave, medicine.disease, Atrial Flutter, lcsh:RC666-701, Internal medicine, Cardiology, Exercise Test, General Earth and Planetary Sciences, Medicine, Humans, business, Sinoventricular conduction, Atrial flutter, General Environmental Science, Aged
Published
2011

12. Imagen de la semana

Author

Luis Morano Amado, Itziar Solla Ruiz, Ana Baz Lomba, and Catalina Fernández Méndez

Subjects
business.industry, X ray computed, Radiography, MEDLINE, Medicine, General Medicine, Nuclear medicine, business
Published
2007

13. Iatrogenic Subclavian Artery Pseudoaneurysm Complicating a Transradial Percutaneous Coronary Intervention

Author

Carlos Manuel Rodriguez-Paz, Raquel Rodriguez-Calveiro, Iñaki Villanueva-Benito, Alberto Ortiz-Saez, Itziar Solla-Ruiz, and Jose Luis Maciñeiras-Montero

Subjects
Adult, Male, medicine.medical_specialty, Percutaneous, Artery procedures, business.industry, medicine.medical_treatment, Iatrogenic Disease, Subclavian Artery, Percutaneous coronary intervention, Drug-Eluting Stents, Vascular System Injuries, medicine.disease, Pseudoaneurysm, medicine.artery, Radial Artery, medicine, Humans, Radiology, Angioplasty, Balloon, Coronary, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Aneurysm, False, Subclavian artery
Abstract

Transradial approach has gained progressive acceptance because it has been shown to have fewer hemorrhagic and vascular-related complications than the femoral approach does for diagnostic and therapeutic percutaneous coronary artery procedures. However, transradial access is not free of

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