1. Efficacy of rivastigmine transdermal therapy on low food intake in patients with Alzheimer's disease: The Attitude Towards Food Consumption in Alzheimer's Disease Patients Revive with Rivastigmine Effects study
- Author
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Norifumi Tsuno, Ichiro Ishikawa, Haeyoung Park, Mariko Tanaka, Nobuyasu Bando, Takahiro Mori, Takayuki Hirano, Yoshito Matsumoto, Yu Nakamura, and Itsuko Mori
- Subjects
Male ,medicine.medical_specialty ,Transdermal patch ,media_common.quotation_subject ,Food consumption ,Appetite ,Transdermal Patch ,Rivastigmine ,Disease ,Severity of Illness Index ,03 medical and health sciences ,Eating ,0302 clinical medicine ,030502 gerontology ,Alzheimer Disease ,Internal medicine ,Statistical significance ,medicine ,Humans ,Cognitive Dysfunction ,Adverse effect ,Original Article: Epidemiology, Clinical Practice and Health ,media_common ,Transdermal ,Aged, 80 and over ,business.industry ,Body Weight ,Original Articles: Epidemiology, Clinical Practice and Health ,Alzheimer's disease ,Mental Status and Dementia Tests ,Treatment Outcome ,Female ,Cholinesterase Inhibitors ,0305 other medical science ,business ,Attitude to Health ,030217 neurology & neurosurgery ,medicine.drug - Abstract
AIM Most patients with Alzheimer's disease (AD) experience poor food intake and/or loss of appetite, which accelerates cognitive impairment. Several reports have shown that rivastigmine improves appetite in AD patients. The present study investigated the efficacy of a rivastigmine transdermal patch for the treatment of low food intake in AD patients. METHODS AD patients, recruited through the Attitude Towards Food Consumption in Alzheimer's Disease Patients Revive with Rivastigmine Effects study, were recognized as experiencing either a loss of appetite or poor food intake. A rivastigmine transdermal patch was administered to study participants for 16 weeks. Patients' food intake, bodyweight, Mini-Mental State Examination scores and any adverse events were recorded. RESULTS A total of 38 patients with AD (age 86.2 ± 5.4 years) were examined. Their mean Mini-Mental State Examination score was 10.1 ± 7.0 at baseline. A significant increase in food intake amount (54.9 ± 98.0 g, P
- Published
- 2018