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6. Experimental study of cavitating flow influenced by heat transfer from heated hydrofoil

Author

Okajima, Junnosuke, Ito, Masaki, and Iga, Yuka

Subjects
Physics - Fluid Dynamics
Abstract

This study experimentally investigated the influence of heat transfer from a heated hydrofoil on cavitating flow to understand the evaporation phenomenon under high-heat-flux and high-speed conditions. A temperature difference was generated between the hydrofoil and mainstream by installing an aluminum nitride heater in a NACA0015 hydrofoil fabricated from copper. A cavitation experiment was performed in a high-temperature water cavitation tunnel at the Institute of Fluid Science, Tohoku University. The effect of heating on cavitating flow was evaluated by changing the mainstream velocity and pressure, namely the cavitation number, at a fixed heater power of 860 W. Results showed that the heat transfer from the hydrofoil affected cavitating flow in terms of the cavity length, cavity aspect, and periodicity. The effect on the cavity length became stronger at a lower velocity owing to a higher hydrofoil temperature. The variation in periodicity implied that the heating effect reduced the unsteadiness of cavitation. A modified cavitation number was proposed by considering the heat transfer from the heated wall. A thermal correction term was derived by considering that the fluid temperature close to the heated hydrofoil was affected by the turbulent convective heat transfer between the mainstream and hydrofoil. The corrected cavitation number can be considered as a parameter that describes the cavity length in the isothermal and heated cases in a unified expression., Comment: Accepted Manuscript in International Journal of Multiphase Flow

Published
2022
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9. The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development

Author

Gombos, Magdolna, Raynaud, Cécile, Nomoto, Yuji, Molnár, Eszter, Brik-Chaouche, Rim, Takatsuka, Hirotomo, Zaki, Ahmad, Bernula, Dóra, Latrasse, David, Mineta, Keito, Nagy, Fruzsina, He, Xiaoning, Iwakawa, Hidekazu, Őszi, Erika, An, Jing, Suzuki, Takamasa, Papdi, Csaba, Bergis, Clara, Benhamed, Moussa, Bögre, László, Ito, Masaki, and Magyar, Zoltán

Published
2023
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11. High-sensitive XANES analysis at Ce L2-edge for Ce in bauxites using transition-edge sensors: Implications for Ti-rich geological samples

Author

Li, Wenshuai, Yamada, Shinya, Hashimoto, Tadashi, Okumura, Takuma, Hayakawa, Ryota, Nitta, Kiyofumi, Sekizawa, Oki, Suga, Hiroki, Uruga, Tomoya, Ichinohe, Yuto, Sato, Toshiki, Toyama, Yuichi, Noda, Hirofumi, Isobe, Tadaaki, Takatori, Sayuri, Hiraki, Takahiro, Tatsuno, Hideyuki, Kominato, Nao, Ito, Masaki, Sakai, Yusuke, Omamiuda, Hajime, Yamaguchi, Akiko, Yomogida, Takumi, Miura, Hikaru, Nagasawa, Makoto, Okada, Shinji, and Takahashi, Yoshio

Published
2023
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17. Five-Year Stroke Risk and Its Predictors in Asymptomatic Moyamoya Disease: Asymptomatic Moyamoya Registry (AMORE)

Author

Kuroda, Satoshi, Yamamoto, Shusuke, Funaki, Takeshi, Fujimura, Miki, Kataoka, Hiroharu, Hishikawa, Tomohito, Takahashi, Jun, Endo, Hidenori, Nariai, Tadashi, Osato, Toshiaki, Saito, Nobuhito, Sato, Norihiro, Hori, Emiko, Ito, Yoichi M., Miyamoto, Susumu, Inaji, Motoki, Morita, Kenichi, Maruyama, Daisuke, Nakagawara, Jyoji, Hashimura, Naoki, Hamano, Eika, Iihara, Koji, Hashimoto, Nobuo, Honjo, Kaori, Nakamura, Hirohiko, Kashiwazaki, Daina, Imai, Hideaki, Miyawaki, Satoru, Hongo, Hiroki, Yoshida, Kazumichi, Kikuchi, Takayuki, Mineharu, Yohei, Isozaki, Makoto, Kikuta, Kenichiro, Araki, Yoshio, Kanamori, Fumiaki, Date, Isao, Ono, Junichi, Machida, Toshio, Mase, Mitsuhito, Katano, Hiroyuki, Yamaguchi, Koji, Kawamata, Takakazu, Tominaga, Teiji, Uchino, Haruto, Tokairin, Kikutaro, Ito, Masaki, Houkin, Kiyohiro, Chida, Kohei, Ogasawara, Kuniaki, Nagata, Izumi, Horie, Nobutaka, Oka, Hidehiro, Kumabe, Toshihiro, Itoh, Yoshiaki, Abe, Takato, Oki, Koichi, Takahashi, Shinichi, and Suzuki, Norihiro

Published
2023
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18. A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

Author

Nomoto, Yuji, Takatsuka, Hirotomo, Yamada, Kesuke, Suzuki, Toshiya, Suzuki, Takamasa, Huang, Ying, Latrasse, David, An, Jing, Gombos, Magdolna, Breuer, Christian, Ishida, Takashi, Maeo, Kenichiro, Imamura, Miyu, Yamashino, Takafumi, Sugimoto, Keiko, Magyar, Zoltán, Bögre, László, Raynaud, Cécile, Benhamed, Moussa, and Ito, Masaki

Published
2022
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19. Standardization of the Definition and Surgical Management of the Splenic Flexure Carcinoma by an International Expert Consensus Using the Delphi Technique: Room for Improvement?

Author

Benlice, Cigdem, Parvaiz, Amjad, Baca, Bilgi, Hohenberger, Werner, Miskovic, Danilo, Stocchi, Luca, Steele, Scott, Kim, Seon-Hahn, Holm, Torbjörn, Spinelli, Antonino, Gogenur, Ismail, Panis, Yves, Hasegawa, Hirotoshi, Karachun, Alexey, Uriburu, Juan C Patron, Ito, Masaki, Croner, Roland, Kessler, Hermann, and Kuzu, Mehmet Ayhan

Published
2023
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20. Enhancing the immunogenicity of Wilms tumor 1 epitope in mesothelioma cells with immunoproteasome inhibitors.

Author

Ito, Masaki, Koido, Shigeo, Iwamoto, Takeo, Morimoto, Soyoko, Fujiki, Fumihiro, Sugiyama, Haruo, Matsumoto, Saki, Effenberger, Clara, Kiyotani, Kazuma, and Shiba, Kiyotaka

Subjects
*TUMOR antigens, *MAJOR histocompatibility complex, *NEPHROBLASTOMA, *IMMUNE response, *CYTOTOXINS, *T cells, *T cell receptors
Abstract

The immunogenicity of cancer cells is influenced by several factors, including the expression of the major histocompatibility complex class I (MHC-I), antigen expression, and the repertoire of proteasome-produced epitope peptides. The malignant pleural mesothelioma cell line ACC-MEOS-4 (MESO-4) expresses high levels of MHC-I and Wilms tumor 1 (WT1) tumor antigens. Using a functional T cell reporter assay specific for the HLA-A*24:02 restricted WT1 epitope (WT1235, CMTWNQMNL), we searched for factors that augmented the immunogenicity of MESO-4, focusing on proteasomes, which have a central role in the antigen processing machinery. ONX-0914, a selective inhibitor of the immunoproteasome subunit β5i, enhanced immunogenicity dose-dependently at low concentrations without cytotoxicity. In addition, CD8+ T lymphocytes recognizing WT1 showed greater cytotoxicity against MESO-4 pre-treated with ONX-0914. MESO-4 expresses a standard proteasome (SP) and immunoproteasome (IP). Notably, IP has distinct catalytic activity from SP, favoring the generation of antigenic peptides with high affinity for MHC-I in antigen-presenting cells and cancer cells. In vitro, immunoproteasome digestion assay and mass spectrometry analysis showed that IP cleaved WT1235 internally after the hydrophobic residues. Importantly, this internal cleavage of the WT1235 epitope was mitigated by ONX-0914. These results suggest that ONX-0914 prevents the internal destructive cleavage of WT1235 by IP, thereby promoting the specific presentation of the WT1 epitope by MESO-4. In conclusion, selective IP inhibitors might offer a means to modulate cancer cell immunogenicity by directing the presentation of particular tumor epitopes. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Sparse Modeling of Nonlinear Dynamics in Heterogeneous Reactions

Author

Ito, Masaki, Kuwatani, Tatsu, Oyanagi, Ryosuke, Omori, Toshiaki, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gedeon, Tom, editor, Wong, Kok Wai, editor, and Lee, Minho, editor

Published
2019
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29. Capturing People Mobility with Mobile Sensing Technology for Disaster Evacuation

Author

Song, Chenwei, Ito, Masaki, Sezaki, Kaoru, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Streitz, Norbert, editor, and Konomi, Shin’ichi, editor

Published
2019
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37. Planning Placement of Distributed Sensor Nodes to Achieve Efficient Measurement

Author

Nakamura, Yuichi, Ito, Masaki, Sezaki, Kaoru, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Streitz, Norbert, editor, and Konomi, Shin’ichi, editor

Published
2018
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39. Diagnostic Value of Vessel Wall Imaging to Determine the Timing of Extracranial‒Intracranial Bypass for Moyamoya Syndrome Associated with Active Sjögren's Syndrome: A Case Report.

Author

Shindo, Takafumi, Ito, Masaki, Sugiyama, Taku, Okuyama, Tomohiro, Kono, Michihito, Atsumi, Tatsuya, and Fujimura, Miki

Abstract

Background Sjögren's syndrome is a chronic autoimmune disorder that predominantly affects exocrine organs. It is characterized by an organ-specific infiltration of lymphocytes. The involvement of the major cerebral arteries in Sjögren's syndrome has rarely been reported. A recent study reported a case of successful extracranial–intracranial (EC–IC) bypass without complications, even in the active inflammatory state, although the optimal timing of such a bypass remains unclear. Case Description We here report the case of a 43-year-old woman presenting with acute ischemic stroke due to progressive middle cerebral artery (MCA) occlusion and signs of primary Sjögren's syndrome. During intensive immunosuppressive therapy for active Sjögren's syndrome, the patient was monitored using contrast-enhanced magnetic resonance vessel wall imaging (MR-VWI). A couple of intravenous cyclophosphamide injections combined with a methylprednisolone pulse and antiplatelet therapy resulted in clear resolution of vessel wall enhancement, which suggested remission of inflammatory vasculitis. Nevertheless, she still experienced a transient ischemic attack (TIA) due to decreased regional cerebral blood flow by MCA occlusion, as demonstrated by the conventional time-of-flight MR angiography and single-photon emission computed tomography. Considering the increased risk of further stroke, the decision was made to perform an EC–IC bypass as a treatment for medically uncontrollable hemodynamic impairment. Her postoperative course was uneventful without further repeated TIAs, and continued immunosuppressive therapy for Sjögren's syndrome provided effective management. Conclusions Our findings emphasize the diagnostic value of contrast-enhanced MR-VWI in monitoring the effect of immunosuppressive therapy for the major cerebral artery vasculitis and in determining the timing of EC–IC bypass as a "rescue" treatment for moyamoya syndrome associated with active Sjögren's syndrome. [ABSTRACT FROM AUTHOR]

Published
2024
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42. A Noonan‐like pediatric patient with a de novo CBL pathogenic variant and an RNF213 polymorphism p.R4810K presenting with cardiopulmonary arrest due to left main coronary artery ostial atresia

Author

Chida‐Nagai, Ayako, primary, Tonoki, Hidefumi, additional, Makita, Naomasa, additional, Ishiyama, Hiroyuki, additional, Ihara, Masafumi, additional, Maruo, Yuji, additional, Tsujioka, Takao, additional, Sasaki, Daisuke, additional, Izumi, Gaku, additional, Yamazawa, Hirokuni, additional, Kato, Nobuyasu, additional, Ito, Masaki, additional, Fujimura, Miki, additional, Sasaki, Osamu, additional, and Takeda, Atsuhito, additional

Published
2023
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43. Contributors

Author

Ali, Muhammad, primary, Anwar, Zobia, additional, Asp, Patrik, additional, Bell, Douglas A, additional, Campbell, Mel, additional, Carlberg, Carsten, additional, Carless, Melanie A., additional, Chen, Xingqi, additional, Choudhury, Yashmin, additional, Coêlho, Marina de Castro, additional, Dalan, Emma, additional, Das, Raima, additional, Davis, Ryan R., additional, del Sol, Antonio, additional, Dzobo, Kevin, additional, Fenstermaker, Tyler K., additional, Ghosh, Sankar Kumar, additional, Grady, W.M., additional, Hausmann, Michael, additional, Hildenbrand, Georg, additional, Hofner, Manuela, additional, Horn, Bradley, additional, Hu, Guoku, additional, Ito, Masaki, additional, Izumiya, Yoshihiro, additional, Joshi, Anagha, additional, Jung, Sascha, additional, Jurkowska, Renata Z, additional, Jurkowski, Tomasz P, additional, Kishi, Yusuke, additional, Krainer, Julie, additional, Kumar, Ashish, additional, Kundu, Sharbadeb, additional, Laskar, Shaheen, additional, Lee, Jin-Ho, additional, Marina, Dunaeva, additional, Mazo, Alexander, additional, Montanera, Kaitlin N., additional, Nakabayashi, Kazuhiko, additional, Neary, Jennifer L., additional, Neme, Antonio, additional, Nöhammer, Christa, additional, Nordlund, Jessica, additional, de Oliveira, Naila Francis Paulo, additional, Pabinger, Stephan, additional, Paul, Amit, additional, Petruk, Svetlana, additional, Pulverer, Walter, additional, Rhee, Ho Sung, additional, Riddle, Nicole C., additional, Romanowska, Julia, additional, Schoelz, John M., additional, Seuter, Sabine, additional, Shibin, Sherin M., additional, Siomi, Haruhiko, additional, Tanić, Miljana, additional, Tepper, Clifford G., additional, Tian, Changhai, additional, Tollefsbol, Trygve O., additional, Tong, Jingjing, additional, Uchino, Haruto, additional, Viana Filho, José Maria Chagas, additional, Wan, Ma, additional, Wang, Zhihua, additional, Weinhäusel, Andreas, additional, Willbanks, A., additional, Williams, Graham, additional, Xie, Yinping, additional, Yamanaka, Soichiro, additional, and Yu, M., additional

Published
2020
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45. Real-Time Visualization of the Degree of Indoor Congestion with Smartphone-Based Participatory Sensing

Author

Kitazato, Tomoya, Ito, Kyoichi, Umezawa, Keisuke, Ito, Masaki, Sezaki, Kaoru, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Streitz, Norbert, editor, and Markopoulos, Panos, editor

Published
2017
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46. Cell Culture

Author

Ito, Masaki, Houkin, Kiyohiro, Houkin, Kiyohiro, editor, Abe, Koji, editor, and Kuroda, Satoshi, editor

Published
2017
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