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7. Establishing a Core Outcome Measure for Peritoneal Dialysis-related Peritonitis: A Standardized Outcomes in Nephrology—Peritoneal Dialysis Consensus Workshop Report

Author

Shen, Jenny I, Cho, Yeoungjee, Manera, Karine E, Brown, Fiona, Dong, Jie, Sahlawi, Muthana Al, Acevedo, Rafael G, Htay, Htay, Ito, Yasuhiko, Kanjanabuch, Talerngsak, Nessim, Sharon J, Ngaruiya, Grace, Piraino, Beth, Szeto, Cheuk-Chun, Teitelbaum, Isaac, Amir, Noa, Craig, Jonathan C, Baumgart, Amanda, Gonzalez, Andrea M, Scholes-Robertson, Nicole, Viecelli, Andrea K, Wilkie, Martin, Tong, Allison, Perl, Jeffrey, Committee, SONG Executive, Craig, Jonathan, Wang, Angela, Hemmelgarn, Brenda, Manns, Braden, Wheeler, David, Gill, John, Tugwell, Peter, Pecoits-Filho, Roberto, Crowe, Sally, Harris, Tess, Van Biesen, Wim, Winkelmayer, Wolfgang, Group, SONG-PD Steering, Johnson, David W, Brown, Edwina, Brunier, Gillian, Manera, Karine, Mehrotra, Rajnish, Dunning, Sue-Ann, Dunning, Tony, Group, SONG-PD Infection Expert Working, Perl, Jeff, Szeto, CC, Forfang, Derek, Gomez, Rafael, Nessim, Sharon, Shen, Jenny, Committee, SONG Coordinating, Martin, Adam, Bernier-Jean, Amelie, Gonzalez, Andrea Matus, Viecelli, Andrea, Ju, Angela, Teixera-Pinto, Armando, Sautenet, Benedicte, Hanson, Camilla, Guha, Chandana, Sumpton, Daniel, Hannan, Elyssa, O’Lone, Emma, Au, Eric, Kerklaan, Jasmijn, Dunn, Louese, Howell, Martin, Nataatmadja, Melissa, Evangelidis, Nicole, Natale, Patrizia, Cazzolli, Rosanna, Anumudu, Samaya, Carter, Simon, Gutman, Talia, and Vastani, Thomas Vastani Rahim

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Clinical Research, Clinical Trials and Supportive Activities, Neurodegenerative, core outcome measure, peritoneal dialysis, peritonitis, trial design, SONG-PD Infection Workshop Investigators, Biomedical and clinical sciences, Health sciences
Abstract

IntroductionPeritoneal dialysis (PD)-related peritonitis is one of the leading causes of discontinuation of PD and is considered a critically important outcome for patients on PD. However, there is no universally accepted method of measuring this outcome in clinical trials.MethodsWe convened an online consensus workshop to establish a core outcome measure for PD-related peritonitis in clinical trials.ResultsA total of 53 participants, including 18 patients and caregivers, from 12 countries engaged in breakout discussions in this workshop. Transcripts were analyzed thematically. We identified the following 3 themes: (i) feasibility and applicability across diverse settings, which reflected the difficulty with implementing laboratory-based measures in resource-limited environments; (ii) ensuring validity, which included minimizing false positives and considering the specificity of symptoms; and (iii) being meaningful and tangible to patients, which meant that the measure should be easy to interpret, reflect the impact that symptoms have on patients, and promote transparency by standardizing the reporting of peritonitis among dialysis units.ConclusionA core outcome measure for PD-related peritonitis should include both symptom-based and laboratory-based criteria. Thus, the International Society for Peritoneal Dialysis (ISPD) definition of peritonitis is acceptable. However, there should be consideration of reporting suspected peritonitis in cases where laboratory confirmation is not possible. The measure should include all infections from the time of catheter insertion and capture both the rate of infection and the number of patients who remain peritonitis free. A core outcome measure with these features would increase the impact of clinical trials on the care and decision-making of patients receiving PD.

Published
2022

12. Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan

Author

Yamaguchi, Makoto, Obayashi, Takaaki, Kobayashi, Naoto, Izumi, Naoki, Nagai, Masaaki, Nobata, Hironobu, Asai, Akimasa, Kamiya, Keisuke, Sugiyama, Hirokazu, Kinashi, Hiroshi, Banno, Shogo, Ando, Masahiko, Imaizumi, Takahiro, Kubo, Yoko, Katsuno, Takayuki, Ishimoto, Takuji, and Ito, Yasuhiko

Published
2023
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25. Pathophysiological Mechanisms of Peritoneal Fibrosis and Peritoneal Membrane Dysfunction in Peritoneal Dialysis.

Author

Ito, Yasuhiko, Sun, Ting, Tawada, Mitsuhiro, Kinashi, Hiroshi, Yamaguchi, Makoto, Katsuno, Takayuki, Kim, Hangsoo, Mizuno, Masashi, and Ishimoto, Takuji

Subjects
*VASCULAR endothelial growth factors, *TRANSFORMING growth factors, *COMPLEMENT activation, *PERITONEAL dialysis, *GROWTH factors
Abstract

The characteristic feature of chronic peritoneal damage in peritoneal dialysis (PD) is a decline in ultrafiltration capacity associated with pathological fibrosis and angiogenesis. The pathogenesis of peritoneal fibrosis is attributed to bioincompatible factors of PD fluid and peritonitis. Uremia is associated with peritoneal membrane inflammation that affects fibrosis, neoangiogenesis, and baseline peritoneal membrane function. Net ultrafiltration volume is affected by capillary surface area, vasculopathy, peritoneal fibrosis, and lymphangiogenesis. Many inflammatory cytokines induce fibrogenic growth factors, with crosstalk between macrophages and fibroblasts. Transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF)-A are the key mediators of fibrosis and angiogenesis, respectively. Bioincompatible factors of PD fluid upregulate TGF-β expression by mesothelial cells that contributes to the development of fibrosis. Angiogenesis and lymphangiogenesis can progress during fibrosis via TGF-β–VEGF-A/C pathways. Complement activation occurs in fungal peritonitis and progresses insidiously during PD. Analyses of the human peritoneal membrane have clarified the mechanisms by which encapsulating peritoneal sclerosis develops. Different effects of dialysates on the peritoneal membrane were also recognized, particularly in terms of vascular damage. Understanding the pathophysiologies of the peritoneal membrane will lead to preservation of peritoneal membrane function and improvements in technical survival, mortality, and quality of life for PD patients. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Establishing a Core Outcome Set for Peritoneal Dialysis: Report of the SONG-PD (Standardized Outcomes in Nephrology–Peritoneal Dialysis) Consensus Workshop

Author

Levin, Adeera, Liew, Adrian, Cueto Manzano, Alfonso, Abu Alfa, Ali, Neu, Alicia, Tong, Allison, Baumgart, Amanda, Bernier-Jean, Amelie, Kelly, Amy, Figueiredo, Ana, Matus, Andrea, Viecelli, Andrea, Ju, Angela, Wang, Angela Yee-Moon, Saxena, Anjali, Sharma, Ankit, Nadeau-Fredette, Annie-Claire, Teixeira-Pinto, Armando, Mendelson, Asher, Kelly, Ayano, Goh, Bak Leong, Sautenet, Benedicte, Manns, Braden, Hemmelgarn, Brenda, Robinson, Bruce, Hanson, Camilla, Cheung, Catherine, Guha, Chandana, Logeman, Charlotte, Szeto, Cheuk-Chun, Rutherford, Claudia, Schwartz, Daniel, Sumpton, Daniel, Johnson, David, Wheeler, David, Brown, Edwina, O’Lone, Emma, Au, Eric, Goffin, Eric, Finkelstein, Fred, Abraham, Georgi, Brunier, Gillian, Germino, Greg, Hurst, Helen, Kawanishi, Hideki, Htay, Htay, Yap, Hui Kim, Teitelbaum, Isaac, Perl, Jeffrey, Chen, Jenny, Shen, Jenny, Dong, Jie, Neumann, Joanna, Bargman, Joanne, Morelle, Johann, Craig, Jonathan, Kilonzo, Kajiru Gad, Yeates, Karen, Manera, Karine, Azukaitis, Karolis, Van, Kim Linh, Dunn, Louese, Krishnan, Mahesh, Lambie, Mark, Howell, Martin, Schreiber, Martin, Wilkie, Martin, Oliver, Matthew, Sanabria, Mauricio Rafael, Nataatmadja, Melissa, Lichodziejewska-Niemierko, Monika, Verdin, Nancy, Mann, Neelam, Boudville, Neil, Evangelidis, Nicole, Scholes-Robertson, Nicole, Blake, Peter, Nourse, Peter, Tugwell, Peter, Li, Philip Kam-Tao, Mehrotra, Rajnish, McGee, Richard, Quinn, Robert, Pecoits-Filho, Roberto, Crowe, Sally, Anumudu, Samaya, Bernays, Sarah, Naicker, Sarala, Wilson, Scott, Nessim, Sharon, Teo, Sharon, Carter, Simon A., Davies, Simon, Sweety, Soheli Ahmed, Gutman, Talia, Toffelmire, Ted, Jassal, Vanita, Jha, Vivekanand, da Silva, Viviane Calice, Van Biesen, Wim, Winkelmayer, Wolfgang, Ito, Yasuhiko, Cho, Yeoungjee, Kim, Yong-Lim, Butt, Zeeshan, Manera, Karine E., Johnson, David W., Craig, Jonathan C., Shen, Jenny I., Brown, Edwina A., Dunning, Tony, and Naicker, Saraladevi

Published
2020
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35. Peritoneal Dialysis Guidelines 2019 Part 1 (Position paper of the Japanese Society for Dialysis Therapy)

Author

Ito, Yasuhiko, Ryuzaki, Munekazu, Sugiyama, Hitoshi, Tomo, Tadashi, Yamashita, Akihiro C., Ishikawa, Yuichi, Ueda, Atsushi, Kanazawa, Yoshie, Kanno, Yoshihiko, Itami, Noritomo, Ito, Minoru, Kawanishi, Hideki, Nakayama, Masaaki, Tsuruya, Kazuhiko, Yokoi, Hideki, Fukasawa, Mizuya, Terawaki, Hiroyuki, Nishiyama, Kei, Hataya, Hiroshi, Miura, Kenichiro, Hamada, Riku, Nakakura, Hyogo, Hattori, Motoshi, Yuasa, Hidemichi, and Nakamoto, Hidetomo

Published
2021
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36. Risk factors of peritoneal dialysis–related peritonitis in the Japan Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).

Author

Ito, Yasuhiko, Tu, Charlotte, Yamaguchi, Makoto, Koide, Shigehisa, Ryuzaki, Munekazu, Bieber, Brian, Pisoni, Ronald L, Perl, Jeffrey, Minakuchi, Jun, Kawanishi, Hideki, and Committee, the Japan PDOPPS Study

Subjects
*PROPORTIONAL hazards models, *PERITONEAL dialysis, *ANTIBIOTIC prophylaxis, *SERUM albumin, *PERITONITIS
Abstract

Background Peritoneal dialysis (PD)-related peritonitis is a major complication of PD. Wide variations in peritonitis prevention, treatment strategies and consequences are seen between countries. These between-country differences may result from modifiable risk factors and clinical practices. Methods A total of 1225 Japanese PD patients were included and prospectively followed in the Peritoneal Dialysis Outcomes and Practice Patterns Study phase 1 (2014–2018) and phase 2 (2018–2022). Associations between PD-related peritonitis and various risk factors were assessed by Cox proportional hazards survival models. Results During follow-up (median 1.52 years), 539 peritonitis episodes were experienced by 364 patients. The country crude peritonitis rate was 0.27 episodes/patient-year. In the fully adjusted model, noticeable patient-level factors associated with experiencing any peritonitis included age {hazard ratio [HR] 1.07 per 5-year increase [95% confidence interval (CI) 1.01–1.14]}, serum albumin level [HR 0.63 per 1 g/dl higher (95% CI 0.48–0.82)] and continuous ambulatory peritoneal dialysis (PD) [HR 1.31 versus automated PD (95% CI 1.05–1.63)]. The adoption of antibiotic prophylaxis practice at the time of PD catheter insertion [HR 0.63 (95% CI 0.51–0.78)] or when having complicated dental procedures [HR 0.74 (95% CI 0.57–0.95)] or lower endoscopy [HR 0.69 (95% CI 0.54–0.89)] were associated with lower hazards of any peritonitis, while a routine facility practice of having more frequent regular medical visits was associated with a higher hazard. Conclusion Identification of risk factors in Japan may be useful for developing future versions of guidelines and improving clinical practices in Japan. Investigation of country-level risk factors for PD-related peritonitis is useful for developing and implementing local peritonitis prevention and treatment strategies [ABSTRACT FROM AUTHOR]

Published
2024
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38. Association of GLIM-Defined Malnutrition in Kidney Dysfunction With Increased All-Cause Mortality from Infections in Hospitalized Older Adults: A Retrospective Cohort Study

Author

Yamaguchi, Makoto, primary, Sugiyama, Hirokazu, additional, Akimasa, Asai, additional, Kamiya, Keisuke, additional, Kitamura, Fumiya, additional, Kinashi, Hiroshi, additional, Katsuno, Takayuki, additional, Bannno, Shogo, additional, Ishimoto, Takuji, additional, Imaizumi, Takahiro, additional, Maeda, Keisuke, additional, Ishida, Yuria, additional, Mori, Naoharu, additional, and Ito, Yasuhiko, additional

Published
2023
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42. Lymphopenia is a risk factor for severe infections in older patients with microscopic polyangiitis: a retrospective cohort study in Japan

Author

Yamaguchi, Makoto, primary, Sugiyama, Hirokazu, additional, Nobata, Hironobu, additional, Kinashi, Hiroshi, additional, Asai, Akimasa, additional, Kitamura, Fumiya, additional, Katsuno, Takayuki, additional, Ando, Masahiko, additional, Kubo, Yoko, additional, Banno, Shogo, additional, Ito, Yasuhiko, additional, and Ishimoto, Takuji, additional

Published
2023
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43. Increased RUNX3 expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts

Author

Koyama, Yu, primary, Okazaki, Hiroya, additional, Shi, Yang, additional, Mezawa, Yoshihiro, additional, Wang, Zixu, additional, Sakimoto, Mizuki, additional, Ishizuka, Akane, additional, Ito, Yasuhiko, additional, Koyama, Takumi, additional, Daigo, Yataro, additional, Takano, Atsushi, additional, Miyagi, Yohei, additional, Yokose, Tomoyuki, additional, Yamashita, Toshinari, additional, Sugahara, Keisuke, additional, Hino, Okio, additional, Yang, Liying, additional, Maruyama, Reo, additional, Katakura, Akira, additional, Yasukawa, Takehiro, additional, and Orimo, Akira, additional

Published
2023
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