Search

Your search keyword '"Ito, Ran"' showing total 36 results
Start Over Author "Ito, Ran"
36 results on '"Ito, Ran"'

9. A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy

Author

Renda, Levent, primary, Tsai, Tsung‐You, additional, Huang, Jung‐Ju, additional, Ito, Ran, additional, Hsieh, Wei‐Chuan, additional, Kao, Huang‐Kai, additional, Hung, Shao‐Yu, additional, Huang, Yenlin, additional, Huang, Yu‐Chen, additional, Chang, Yu‐Liang, additional, Cheng, Ming‐Huei, additional, and Chang, Kai‐Ping, additional

Published
2019
Full Text
View/download PDF

10. A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy.

Author

Renda, Levent, Tsai, Tsung‐You, Huang, Jung‐Ju, Ito, Ran, Hsieh, Wei‐Chuan, Kao, Huang‐Kai, Hung, Shao‐Yu, Huang, Yenlin, Huang, Yu‐Chen, Chang, Yu‐Liang, Cheng, Ming‐Huei, Chang, Kai‐Ping, Tsai, Tsung-You, Huang, Jung-Ju, Hsieh, Wei-Chuan, Kao, Huang-Kai, Hung, Shao-Yu, Huang, Yu-Chen, Chang, Yu-Liang, and Cheng, Ming-Huei

Abstract

Objective: There is no useful tool to clinically predict the occurrence of osteoradionecrosis (ORN) of the mandible quantitatively. The aim was to investigate the risk factors, including different modalities of radiotherapy, for developing mandibular ORN in patients undergoing marginal mandibulectomy and postoperative radiotherapy.Methods: Between January 2006 and December 2012, 167 subjects who underwent marginal mandibulectomy and postoperative radiotherapy with different modalities were enrolled. The association of ORN with mandibular bone measurements and patient variables was analyzed, and a nomogram was established.Results: Fifteen (8.98%) of the 167 patients developed ORN during the follow-up period, and ORN was significantly associated with diabetes mellitus (DM), body mass index (BMI), remaining bone height, remaining bone height to original bone height ratio, resected bone height to original bone height ratio, and mandibular dose (P: < 0.001, 0.004, 0.042, 0.018, 0.010, 0.020, respectively). Interestingly, the risk of ORN had no significant difference between conformal and intensity modulation radiation therapy (P = 0.407). Multivariate analysis revealed that DM and resected bone height to original bone height ratio ≥ 50% were independent risk factors for postoperative ORN. A nomogram consisting of BMI, DM, resected bone height to original bone height ratio, mandibulotomy, and mandibular dose for predicting the ORN-free probability was established; and the c-index of the nomogram for ORN status was 0.803.Conclusion: A nomogram based on the risk factors was plotted to strengthen the prediction of ORN quantitatively. Surgeons should be more discrete regarding the treatment plan for patients with higher probability of ORN.Level Of Evidence: 3b Laryngoscope, 130:101-107, 2020. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

19. Challenging a Traditional Paradigm

Author

Chang, Edward I., primary, Chang, Eric I., additional, Ito, Ran, additional, Zhang, Hong, additional, Nguyen, Alexander T., additional, Skoracki, Roman J., additional, Hanasono, Matthew M., additional, Crosby, Melissa A., additional, Ueno, Naoto T., additional, and Hunt, Kelly K., additional

Published
2015
Full Text
View/download PDF

24. Simple and longstanding adipose tissue engineering in rabbits.

Author

00768921, 40378641, 50211371, 10207516, Tsuji, Wakako, Inamoto, Takashi, Ito, Ran, Morimoto, Naoki, Tabata, Yasuhiko, Toi, Masakazu, 00768921, 40378641, 50211371, 10207516, Tsuji, Wakako, Inamoto, Takashi, Ito, Ran, Morimoto, Naoki, Tabata, Yasuhiko, and Toi, Masakazu

Abstract

Adipose tissue engineering for breast reconstruction can be performed for patients who have undergone breast surgery. We have previously confirmed adipogenesis in mice implanted with type I collagen sponge with controlled release of fibroblast growth factor 2 (FGF2) and human adipose tissue-derived stem cells. However, in order to use this approach to treat breast cancer patients, a large amount of adipose tissue is needed, and FGF2 is not readily available. Thus, we aimed to regenerate large amounts of adipose tissue without FGF2 for a long period. Under general anesthesia, cages made of polypropylene mesh were implanted into the rabbits' bilateral fat pads. Each cage was 10 mm in radius and 10 mm in height. Minced type I collagen sponge was injected as a scaffold into the cage. Regenerated tissue in the cage was examined with ultrasonography, and the cages were harvested 3, 6, and 12 months after the implantation. Ultrasonography revealed a gradually increasing homogeneous high-echo area in the cage. Histology of the specimen was assessed with hematoxylin and eosin staining. The percentages of regenerated adipose tissue area were 76.2 ± 13.0 and 92.8 ± 6.6 % at 6 and 12 months after the implantation, respectively. Our results showed de novo adipogenesis 12 months after the implantation of only type I collagen sponge inside the space. Ultrasonography is a noninvasive and useful method of assessing the growth of the tissue inside the cage. This simple method could be a promising clinical modality in breast reconstruction.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results