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326 results on '"Ito, Mizuki"'

4. Randomized controlled trial of KW-6356 monotherapy in patients with early untreated Parkinson's disease

Author

Abe, Takashi, Deguchi, Kentaro, Fujimoto, Kenichi, Hasegawa, Kazuko, Hatsuta, Hiroyuki, Hattori, Nobutaka, Hattori, Tatsuya, Ikebe, Shinichiro, Ishida, Yoshinori, Ishikawa, Mitsunori, Isobe, Chiaki, Ito, Kazunori, Ito, Mizuki, Kaneko, Chikako, Kaneko, Satoshi, Kanzato, Naomi, Kawashima, Noriko, Kitamura, Takeshi, Kitayama, Michio, Kimura, Takashi, Kosaka, Satoru, Tetsuya, Maeda, Mochizuki, Hideki, Morimoto, Nobutoshi, Murata, Miho, Naka, Takashi, Negishi, Teruhiko, Nishida, Yoshihiko, Nomoto, Masahiro, Orimo, Satoshi, Saiki, Hidemoto, Sakata, Mayumi, Sato, Akira, Shimo, Yasushi, Suzuki, Keisuke, Takahashi, Ryosuke, Takeda, Atsushi, Tatsuoka, Yoshihisa, Toda, Kazuo, Tomiyama, Masahiko, Toru, Shuta, Tsuboi, Yoshio, Tsujino, Akira, Uozumi, Takenori, Yamada, Hitoshi, Yamamoto, Mitsutoshi, Yoshida, Kazuto, Yoshinaga, Junji, Maeda, Tetsuya, Sugiyama, Kenichiro, Yamada, Kana, Hiraiwa, Ren, and Nishi, Masato

Published
2023
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6. Elevated cerebrospinal fluid IgG index in herpes simplex encephalitis post‐HSV‐1 clearance: A preliminary study.

Author

Asakura, Mao, Mizutani, Yasuaki, Shima, Sayuri, Kawamura, Yoshiki, Ueda, Akihiro, Ito, Mizuki, Mutoh, Tatsuro, Yoshikawa, Tetsushi, and Watanabe, Hirohisa

Subjects
HUMAN herpesvirus 1, HERPES simplex, HERPES simplex virus, CEREBROSPINAL fluid, IMMUNOGLOBULIN G, CHICKENPOX
Abstract

Herpes simplex encephalitis (HSE) is an acute form of encephalitis that can lead to poor neurological outcomes. Although the exact pathogenesis of HSE remains elusive, recent reports suggest a significant role for postinfectious immune‐inflammatory processes in the central nervous system (CNS). This study aimed to clarify the association between CNS autoimmune responses and clinical presentation in patients with HSE, focusing on cerebrospinal fluid (CSF) characteristics, particularly the IgG index. We retrospectively analyzed 176 consecutive patients suspected of having aseptic meningitis /encephalitis for chronological changes in CSF findings and clinical presentations. These patients underwent PCR screening for herpesviruses (HV) in their CSF. We identified seven patients positive for herpes simplex virus type 1 (HSV‐1), 20 patients positive for varicella‐zoster virus, and 17 patients who met the criteria for aseptic meningitis but were PCR‐negative for HV. Patients in the HSV‐1‐positive group exhibited a significant increase in the IgG index at the time of PCR‐negative conversion compared with on admission (p = 0.0156), while such a change was not observed in the other two groups. Additionally, all patients in the HSV‐1‐positive group tested negative for anti‐neural autoantibodies in CSF and serum samples collected approximately 3 weeks after onset. This study, therefore, highlights that CSF IgG index elevation occurs even after PCR‐confirmed HSV‐1 clearance, which might indicate immunopathogenesis that is independent of antibody‐mediated mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Genome-wide association analysis identifies PLA2G4C as a susceptibility locus for Multiple System Atrophy

Author

Tsuji, Shoji, primary, Nakahara, Yasuo, additional, Mitsui, Jun, additional, Date, Hidetoshi, additional, Porto, Kristine Joyce, additional, Hyashi, Yasuhiro, additional, Yamashita, Atsushi, additional, Kusakabe, Yoshio, additional, Matsukawa, Takashi, additional, Ishiura, Hiroyuki, additional, Yasuda, Tsutomu, additional, Iwata, Atsushi, additional, Goto, Jun, additional, Ichikawa, Yaeko, additional, Momose, Yoshio, additional, Takahashi, Yuji, additional, Toda, Tatsushi, additional, Ohta, Rikifumi, additional, Yoshimura, Jun, additional, Morishita, Shinichi, additional, Gustavsson, Emil, additional, Christy, Darren, additional, Maczis, Melisa, additional, Kim, Han-Joon, additional, Park, Sung-Sup, additional, Zhang, Jin, additional, Gu, Weihong, additional, Scholz, Sonja, additional, Chelban, Viorica, additional, Mok, Kin, additional, Houlden, Henry, additional, Yabe, Ichiro, additional, Sasaki, Hidenao, additional, Matsushima, Masaaki, additional, Takashima, Hiroshi, additional, Kikuchi, Akio, additional, Aoki, Masashi, additional, Hara, Kenju, additional, Kakita, Akiyoshi, additional, Yamada, Mitsunori, additional, Takahashi, Hitoshi, additional, Onodera, Osamu, additional, Nishizawa, Masatoyo, additional, Watanabe, Hirohisa, additional, Ito, Mizuki, additional, Sobue, Gen, additional, Ishikawa, Kinya, additional, Mizusawa, Hidehiro, additional, Kanai, Kazuaki, additional, Kuwabara, Satoshi, additional, Arai, Kimihito, additional, Koyano, Shigeru, additional, Kuroiwa, Yoshiyuki, additional, Hasegawa, Kazuko, additional, Yuasa, Tatsuhiko, additional, Yasui, Kenichi, additional, Nakashima, Kenji, additional, Ito, Hijiri, additional, Izumi, Yuishin, additional, Kaji, Ryuji, additional, kato, Takeo, additional, Kusunoki, Susumu, additional, Osaki, Yasushi, additional, Horiuchi, Masahiro, additional, Yamamoto, Ken, additional, Shimada, Mihoko, additional, Miyagawa, Taku, additional, Kawai, Yosuke, additional, Nishida, Nao, additional, Tokunaga, Katsushi, additional, Durr, Alexandra, additional, Brice, Alexis, additional, Filla, Alessandro, additional, Klockgether, Thomas, additional, Wuellner, Ullrich, additional, Tanner, Caroline, additional, Kukull, Walter, additional, Lee, Virginia, additional, Masliah, Eliezer, additional, Low, Phillip, additional, Sandroni, Paola, additional, Ozelius, Laurie, additional, Foroud, Tatiana, additional, Farrer, Matthew, additional, and Trojanowski, John, additional

Published
2024
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10. Correlations between serotonin impairments and clinical indices in multiple system atrophy.

Author

Nagao, Ryunosuke, Mizutani, Yasuaki, Shima, Sayuri, Ueda, Akihiro, Ito, Mizuki, Yoshimoto, Junichiro, and Watanabe, Hirohisa

Subjects
DIASTOLIC blood pressure, SEROTONIN syndrome, SEROTONIN, SYSTOLIC blood pressure, HIGH performance liquid chromatography, STRUCTURAL equation modeling, MULTIPLE system atrophy
Abstract

Background and purpose: Multiple system atrophy (MSA) is a neurodegenerative disease with characteristic motor and autonomic symptoms. Impaired brain serotonergic innervation can be associated with various clinical indices of MSA; however, the relationship between clinical symptoms and cerebrospinal fluid (CSF) levels of 5‐hydroxyindole acetic acid (5‐HIAA), a main serotonin metabolite, has not been fully elucidated. Methods: To compare CSF 5‐HIAA levels between patients with MSA and healthy controls, we included 33 controls and 69 MSA patients with either predominant parkinsonian or cerebellar ataxia subtypes. CSF 5‐HIAA levels were measured using high‐performance liquid chromatography. Additionally, we investigated correlations between CSF 5‐HIAA and various clinical indices in 34 MSA patients. Results: CSF 5‐HIAA levels were significantly lower in MSA patients than in controls (p < 0.0001). Probable MSA patients had lower CSF 5‐HIAA levels than possible MSA patients (p < 0.001). In MSA patients, CSF 5‐HIAA levels were inversely correlated with scores in Parts 1, 2, and 4 of the Unified Multiple System Atrophy Rating Scale, and with systolic and diastolic blood pressure in Part 3. Structural equation modeling revealed significant paths between serotonin and clinical symptoms, and significance was highest for activities of daily living, walking, and body sway. Conclusions: Serotonin dysfunction, as assessed by CSF 5‐HIAA levels, may implicate greater MSA severity. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Irreversible Structural Phase Transition in [(9‐triptycylammonium) ([18]crown‐6)][Ni(dmit)2]: Origin and Effects on Electrical and Magnetic Properties

Author

Manabe, Jun, primary, Sako, Nagisa, additional, Ito, Mizuki, additional, Fujibayashi, Masaru, additional, Kato, Chisato, additional, Cosquer, Goulven, additional, Inoue, Katsuya, additional, Takahashi, Kiyonori, additional, Nakamura, Takayoshi, additional, Akutagawa, Tomoyuki, additional, Shimono, Seiya, additional, Ishibashi, Hiroki, additional, Kubota, Yoshiki, additional, and Nishihara, Sadafumi, additional

Published
2023
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19. Irreversible Structural Phase Transition in [(9‐triptycylammonium) ([18]crown‐6)][Ni(dmit)2]: Origin and Effects on Electrical and Magnetic Properties.

Author

Manabe, Jun, Sako, Nagisa, Ito, Mizuki, Fujibayashi, Masaru, Kato, Chisato, Cosquer, Goulven, Inoue, Katsuya, Takahashi, Kiyonori, Nakamura, Takayoshi, Akutagawa, Tomoyuki, Shimono, Seiya, Ishibashi, Hiroki, Kubota, Yoshiki, and Nishihara, Sadafumi

Subjects
PHASE transitions, REVERSIBLE phase transitions, MAGNETIC properties, MAGNETIC anomalies, MAGNETIC susceptibility
Abstract

Materials exhibiting irreversible phase transitions, leading to changes in their properties, have a potential for novel application in electronic components such as a non‐rewritable high‐security memory. Here, we focused on the two salts, [(9‐triptycylammonium)([18]crown‐6)][Ni(dmit)2] (1) and [(9‐triptycylammonium)([15]crown‐5)][Ni(dmit)2] (2), which featured 2D sheet structures with alternately stacked cation and anion layers. Both salts exhibit similar cation arrangements, however, their anion arrangements differ significantly. The temperature‐dependent magnetic susceptibilities of 1 and 2 were well reproduced by the alternating chain model (JAC1/kB=−306(8), JAC2/kB=−239(3) K) and the Curie‐Weiss model (θ=−3.9(1) K), respectively. 1 experience a reversible phase transition around 40–60 K, causing anomalies in magnetic behavior. Moreover, an irreversible single‐crystal‐to‐single‐crystal phase transition to 1′ undergo at ~381 K, inducing a rearrangement of [Ni(dmit)2]− anions and a resistivity decrease from 6.5×106 to 6.5×102 Ω cm. The susceptibility curve of 1′ was reproduced by a combination of the Curie‐Weiss and dimer models (Jdimer/kB=−407(5), θ=−26.7(5) K). The irreversible transition of 1 is the first example for such supramolecule and [Ni(dmit)2]− system to our knowledge, in opening potential new‐type materials. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson’s disease

Author

Kawabata, Kazuya, Watanabe, Hirohisa, Hara, Kazuhiro, Bagarinao, Epifanio, Yoneyama, Noritaka, Ogura, Aya, Imai, Kazunori, Masuda, Michihito, Yokoi, Takamasa, Ohdake, Reiko, Tanaka, Yasuhiro, Tsuboi, Takashi, Nakamura, Tomohiko, Hirayama, Masaaki, Ito, Mizuki, Atsuta, Naoki, Maesawa, Satoshi, Naganawa, Shinji, Katsuno, Masahisa, and Sobue, Gen

Published
2018
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21. Genome-wide association study identifies a new susceptibility locus inPLA2G4Cfor Multiple System Atrophy

Author

Nakahara, Yasuo, primary, Mitsui, Jun, additional, Date, Hidetoshi, additional, Porto, Kristine Joyce, additional, Hayashi, Yasuhiro, additional, Yamashita, Atsushi, additional, Kusakabe, Yoshio, additional, Matsukawa, Takashi, additional, Ishiura, Hiroyuki, additional, Yasuda, Tsutomu, additional, Iwata, Atsushi, additional, Goto, Jun, additional, Ichikawa, Yaeko, additional, Momose, Yoshio, additional, Takahashi, Yuji, additional, Toda, Tatsushi, additional, Ohta, Rikifumi, additional, Yoshimura, Jun, additional, Morishita, Shinichi, additional, Gustavsson, Emil K, additional, Christy, Darren, additional, Maczis, Melissa, additional, Farrer, Matthew J., additional, Kim, Han-Joon, additional, Park, Sung-Sup, additional, Jeon, Beomseok, additional, Zhang, Jin, additional, Gu, Weihong, additional, Scholz, Sonja W., additional, Singleton, Andrew B., additional, Houlden, Henry, additional, Yabe, Ichiro, additional, Sasaki, Hidenao, additional, Matsushima, Masaaki, additional, Takashima, Hiroshi, additional, Kikuchi, Akio, additional, Aoki, Masashi, additional, Hara, Kenju, additional, Kakita, Akiyoshi, additional, Yamada, Mitsunori, additional, Takahashi, Hitoshi, additional, Onodera, Osamu, additional, Nishizawa, Masatoyo, additional, Watanabe, Hirohisa, additional, Ito, Mizuki, additional, Sobue, Gen, additional, Ishikawa, Kinya, additional, Mizusawa, Hidehiro, additional, Kanai, Kazuaki, additional, Kuwabara, Satoshi, additional, Arai, Kimihito, additional, Koyano, Shigeru, additional, Kuroiwa, Yoshiyuki, additional, Hasegawa, Kazuko, additional, Yuasa, Tatsuhiko, additional, Yasui, Kenichi, additional, Nakashima, Kenji, additional, Ito, Hijiri, additional, Izumi, Yuishin, additional, Kaji, Ryuji, additional, Kato, Takeo, additional, Kusunoki, Susumu, additional, Osaki, Yasushi, additional, Horiuchi, Masahiro, additional, Yamamoto, Ken, additional, Shimada, Mihoko, additional, Miyagawa, Taku, additional, Kawai, Yosuke, additional, Nishida, Nao, additional, Tokunaga, Katsushi, additional, Dürr, Alexandra, additional, Brice, Alexis, additional, Filla, Alessandro, additional, Klockgether, Thomas, additional, Wüllner, Ullrich, additional, Tanner, Caroline M., additional, Kukull, Walter A., additional, Lee, Virginia M.-Y., additional, Masliah, Eliezer, additional, Low, Phillip A., additional, Sandroni, Paola, additional, Ozelius, Laurie, additional, Foroud, Tatiana, additional, and Tsuji, Shoji, additional

Published
2023
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35. Diagnostic Accuracy of Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis: A Systematic Review and Individual Patient Data Meta-Analysis

Author

Foerster, Bradley R., Dwamena, Ben A., Petrou, Myria, Carlos, Ruth C., Callaghan, Brian C., Churchill, Cristina L., Mohamed, Mona A., Bartels, Claudia, Benatar, Michael, Bonzano, Laura, Ciccarelli, Olga, Cosottini, Mirco, Ellis, Cathy M., Ehrenreich, Hannelore, Filippini, Nicola, Ito, Mizuki, Kalra, Sanjay, Melhem, Elias R., Pyra, Timothy, Roccatagliata, Luca, Senda, Joe, Sobue, Gen, Turner, Martin R., Feldman, Eva L., and Pomper, Martin G.

Published
2013
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36. Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis

Author

Tohnai, Genki, Nakamura, Ryoichi, Sone, Jun, Nakatochi, Masahiro, Yokoi, Daichi, Katsuno, Masahisa, Watanabe, Hazuki, Watanabe, Hirohisa, Ito, Mizuki, Li, Yuanzhe, Izumi, Yuishin, Morita, Mitsuya, Taniguchi, Akira, Kano, Osamu, Oda, Masaya, Kuwabara, Satoshi, Abe, Koji, Aiba, Ikuko, Okamoto, Koichi, Mizoguchi, Kouichi, Hasegawa, Kazuko, Aoki, Masashi, Hattori, Nobutaka, Onodera, Osamu, Naruse, Hiroya, Mitsui, Jun, Takahashi, Yuji, Goto, Jun, Ishiura, Hiroyuki, Morishita, Shinichi, Yoshimura, Jun, Doi, Koichiro, Tsuji, Shoji, Nakashima, Kenji, Kaji, Ryuji, Atsuta, Naoki, and Sobue, Gen

Published
2018
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41. Severe dysautonomia in glycine receptor antibody-positive progressive encephalomyelitis with rigidity and myoclonus (PERM): A case report

Author

Mizutani, Yasuaki, primary, Adachi, Shunsuke, additional, Nakano, Shoko, additional, Hayashi, Kazutaka, additional, Higashi, Atsuhiro, additional, Kikuchi, Kouichi, additional, Maeda, Toshiki, additional, Murate, Kenichiro, additional, Shima, Sayuri, additional, Iizuka, Takahiro, additional, Ueda, Akihiro, additional, Ito, Mizuki, additional, and Watanabe, Hirohisa, additional

Published
2022
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42. Nemaline Myopathy Initially Diagnosed as Right Heart Failure with Type 2 Respiratory Failure

Author

Ito, Mizuki, primary, Shima, Sayuri, additional, Ryunosuke, Nagao, additional, Nakano, Shoko, additional, Esaka, Konoka, additional, Ueda, Akihiro, additional, Maeda, Shingo, additional, Moriya, Ryoma, additional, Kondo, Masashi, additional, Imaizumi, Kazuyoshi, additional, Noda, Seiya, additional, Katsuno, Masahisa, additional, Nishino, Ichizo, additional, and Watanabe, Hirohisa, additional

Published
2022
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43. Long duration prognosis of hypertrophic pachymeningitis

Author

Ueda, Akihiro, Senda, Mayumi, Kato, Kunihisa, Adachi, Syunske, Esaka, Konoka, Tsujimura, Yuji, Nakano, Syuko, Hayashi, Kazutaka, Banno, Fumihiko, Kikuchi, Koichi, Higashi, Atsuhiro, Nagao, Ryunosuke, Maeda, Toshiki, Kako, Tetsuharu, Hirota, Seiko, Ishikawa, Tomomasa, Mizutani, Yasuaki, Shima, Sayuri, Ito, Mizuki, Ito, Shinji, Mutoh, Tatsuro, and Watanabe, Hirohisa

Published
2021
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44. Characteristics of Neural Network Changes in Normal Aging and Early Dementia

Author

Watanabe, Hirohisa, primary, Bagarinao, Epifanio, additional, Maesawa, Satoshi, additional, Hara, Kazuhiro, additional, Kawabata, Kazuya, additional, Ogura, Aya, additional, Ohdake, Reiko, additional, Shima, Sayuri, additional, Mizutani, Yasuaki, additional, Ueda, Akihiro, additional, Ito, Mizuki, additional, Katsuno, Masahisa, additional, and Sobue, Gen, additional

Published
2021
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45. Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke A Randomized Clinical Trial and Meta-analysis

Author

Kitagawa Kazuo, Yamamoto Yasumasa, Arima Hisatomi, Maeda Toshiki, Sunami Norio, Kanzawa Takao, Eguchi Kazuo, Kamiyama Kenji, Minematsu Kazuo, Ueda Shinichiro, Rakugi Hiromi, Ohya Yusuke, Kohro Takahide, Yonemoto Koji, Okada Yasushi, Higaki Jitsuo, Tanahashi Norio, Kimura Genjiro, Umemura Satoshi, Matsumoto Masayasu, Shimamoto Kazuaki, Ito Sadayoshi, Saruta Takao, Shimada Kazuyuki, Kario Kazuomi, Saito Yoshihiko, Terayama Yasuo, Toyoda Kazunori, Okura Takafumi, Hoshino Haruhiko, Makino Hirofumi, Uchida Haruhito, Uchiyama Shinichiro, Etani Hideki, Kohriyama Tatsuo, Tomimoto Hidekazu, Yoshio Taku, Kobayashi , Shotai, Usami Hiroko, Iihoshi Satoshi, Mikami Takeshi, Mikuni Nobuhiro, Miyata Kei, Murakami Tomohiro, Endo Hideki, Fukui Takahito, Fumoto Kentaro, Hara Keiji, Honjo Kaori, Kinoshita Yusuke, Maeda Masana, Mikamoto Masaaki, Mori Daisuke, Murahashi Takeo, Nomura Ryota, Noro Shusaku, Ogino Tatsuya, Okuma Masahiro, Otake Yasuhumi, Shindo Koichiro, Sugio Hironori, Takada Hidekazu, Takahira Kazuki, Takeuchi Akiko, Watanabe Toshiichi, Yamaguchi Yohei, Abumiya Takeo, Houkin Kiyohiro, Matsumura Shigeki, Shinohe Rikiya, Kuroshima Kiyomi, Takizawa Katsumi, Yoshida Kazuto, Morimoto Hideo, Hasebe Naoyuki, Koyama Satoshi, Maruyama Junichi, Irie Shinsuke, Nakano Takahiro, Ogasawara Yukari, Ohkuma Hiroki, Shibanai Kazuo, Hikichi Kentaro, Kobayashi Shinya, Moroi Junta, Nakase Taizen, Okada Takeshi, Takano Daiki, Takenaka Shunsuke, Yoshioka Shotaro, Yanagisawa Toshiharu, Hirata Yutaka, Konno Shu, Sato Tomohiko, Ito Miiko, Kondo Rei, Mori Wataru, Saito Shinjiro, Kokubo Yasuaki, Kato Hideaki, Oyama Hideki, Matsuo Kaneyuki, Matsumoto Masahiro, Nakamura Mari, Koizumi Takayuki, Sato Hiroyuki, Shibata Yasushi, Hashimoto Masaaki, Kurita Hideharu, Matsumoto Eiji, Ishiguro Koji, Asakura Ken, Fujimaki Hiroya, Wakabayashi Kazuki, Akaji Kazunori, Horikoshi Tomo, Kano Tadashige, Katano Takehiro, Kimura Hiroaki, Mihara Ban, Suzuki Kentaro, Takayama Yohei, Ishii Akira, Momomura Sin-ichi, Sugawara Hitoshi, Yamashita Takeshi, Kaneko Uichi, Takahashi Toshie, Arai Toshinari, Tanaka Yoshihiro, Inokuma Shigehisa, Kato Yuji, Ishige Naoki, Muramatsu Kazuhiro, Nogawa Shigeru, Yoshizaki Takahito, Ohashi Takashi, Suda Sumio, Iguchi Yasuyuki, Mitsumura Hidetaka, Adachi Tomohide, Konoeda Fumie, Oki Koichi, Tanaka Ryota, Urabe Takao, Yamashiro Kazuo, Ito Akihiro, Nakatomi Hirofumi, Shojima Masaaki, Otsuka Kuniaki, Shibata Koichi, Abe Takato, Itoh Yoshiaki, Suzuki Norihiro, Toi Sono, Teramoto Tamio, Fukunaga Atsushi, Kujuro Yuki, Ohta Kouichi, Osada Takashi, Shimizu Katuyoshi, Kitagawa Yasuhisa, Tokuoka Kentaro, Omura Masao, Kikyo Hideyuki, Kamide Tomoya, Kitamura Yoshihisa, Miyashita Katsuyoshi, Mori Kentaro, Shima Hiroshi, Tamase Akira, Akutsu Tsugio, Nishiyama Kazutoshi, Takizawa Shunya, Uesugi Tsuyoshi, Ikeda Uichi, Koshikawa Megumi, Yamasaki Saeko, Inoue Atsushi, Matsumoto Yasuko, Yamaguchi Kazuyoshi, Hirose Genjirou, Kontani Satoshi, Takasawa Kazuya, Hirahara Katsumi, Kodama Makoto, Yagihara Nobue, Hata Takashi, Hori Makoto, Oda Rokuhei, Kubo Ayuka, Okuda Satoshi, Yamada Kentaro, Takeuchi Hiroki, Araki Yoshio, Ito Mizuki, Senda Joe, Wakabayashi Toshihiko, Ito Shinji, Mutoh Tatsuro, Kawase Yukinori, Ando Fumio, Okamoto Shinya, Shimada Takuya, Shindo Akihiro, Nishikawa Masakatsu, Niwa Atsushi, Sasaki Ryogen, Murata Hiroto, Yata Kenichiro, Matsuo Koushun, Yagi Hideo, Shiogai Toshiyuki, Nagakane Yoshinari, Fujinami Jun, Nakagawa Masanori, Ohara Ryo, Tomii Yasuhiro, Arakawa Yoshiki, Funaki Takeshi, Ihara Masafumi, Kitamura Akihiro, Maki Takakuni, Miyamoto Susumu, Nakaya Yoshifumi, Takahashi Ryosuke, Takenobu Yohei, Yoshida Kazumichi, Ino Tadashi, Murase Nagako, Ohotani Ryo, Kawashima Atsushi, Watanabe Akiko, Hayashi Yuko, Ohmichi Takuma, Yasuda Rei, Yoshioka Akira, Yuki Natsuko, Makino Masahiro, Yamaguchi Tatsuyuki, Matsuzaki Jyo, Niki Hitoshi, Shiraishi Shoichi, Yanagihara Takehiko, Yamada Keiichi, Hatate Jun, Miwa Kaori, Okazaki Shuhei, Arihiro Shoji, Doijiri Ryosuke, Higashida Kyoko, Kajimoto Katsufumi, Miyashita Kotaro, Nagatsuka Kazuyuki, Saito Kozue, Sugiura Yuri, Takizawa Hotake, Torii Takako, Yokota Chiaki, Kajimoto Yoshinaga, Kuroiwa Toshihiko, Fukunaga Ryuzo, Takahashi Tsutomu, Nakao Kazutami, Kajiyama Yuta, Kimura Yasuyoshi, Naka Takashi, Otomune Hironori, Tanahashi Takao, Uehara Takuya, Hashimoto Hiroyuki, Uematsu Toshihiko, Kataoka Kazuo, Okayama Satoshi, Somekawa Satoshi, Yamada Shuichi, Sasaki Rie, Yamano Shigeru, Nakao Naoyuki, Obayashi Shinji, Hamaguchi Hirotoshi, Toda Tatsushi, Washida Kazuo, Hoshi Taku, Kono Tomoyuki, Sekiya Hiroaki, Sugo Norifumi, Todo Kenichi, Togo Masaya, Yamagami Hiroshi, Yamamoto Shiro, Shiro Yoshihiko, Takaoka Toshio, Abe Satoshi, Hamada Chizuko, Ishihara Masaki, Kadota Katuhiko, Nakagawa Tomonori, Oguro Hiroaki, Takayoshi Hiroyuki, Yamaguchi Takuya, Yamaguchi , Shuuhei, Mizuhara Ryo, Okada Kazunori, Yamagata Shingo, Sasaki Akira, Abe Koji, Deguchi Kentaro, Deguchi Shoko, Nakano Yumiko, Hirai Satoshi, Uno Masaaki, Yokosuka Kimihiko, Manabe Yasuhiro, Ito Hijiri, Aoki Shiro, Hosomi Naohisa, Kihara Yasuki, Kisaka Tomohiko, Maruyama Hirofumi, Araki Hayato, Ogami Ryo, Torii Tsuyoshi, Yokoyama Noboru, Yokoyama Takakazu, Kataoka Satoshi, Kitamura Takeshi, Kanda Takashi, Maeda Toshihiko, Shimizu Fumitaka, Seki Kozaburo, Bando Yuko, Ohara Masaki, Yamasaki Masahiro, Masahira Noritaka, Ueba Tetsuya, Ueba Yusuke, Fujimoto Yuichi, Haro Keiko, Ogata Hidenori, Shida Norihiko, Matsumoto Takeshi, Okamoto Kensho, Kawamoto Ryuichi, Arakawa Shuji, Shii Hirofumi, Kanai Hidetoshi, Fujimoto Shigeru, Jinnouchi Juro, Matsuki Takayuki, Osaki Masato, Arakawa Kimika, Ibaraki Ai, Kiyohara Kanako, Ohta Yuko, Oniki Hideyuki, Sakaki Minako, Tominaga Mitsuhiro, Tsuchihashi Takuya, Higashi Saho, Ishikawa Hiromi, Ishitsuka Koji, Kitayama Jiro, Nakane Hiroshi, Yoshimura Takeo, Kakino Shunsuke, Kaneko Yoshirou, Inoue Junnosuke, Maruyama Yoshikazu, Isa Katsunori, Sakima Hirokuni, and Nakada Seigo

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Standard treatment, Population, medicine.disease, law.invention, 03 medical and health sciences, 0302 clinical medicine, Blood pressure, Randomized controlled trial, law, Relative risk, Internal medicine, Multicenter trial, Number needed to treat, Medicine, 030212 general & internal medicine, Neurology (clinical), business, education, Stroke, 030217 neurology & neurosurgery, Original Investigation
Abstract

Importance The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown. Objective To assess whether intensive BP control would achieve fewer recurrent strokes vs standard BP control. Design, Setting, and Participants Randomized clinical trial (RCT) of standard vs intensive BP control in an intent-to-treat population of patients who had a history of stroke. Patients were enrolled between October 20, 2010, and December 7, 2016. For an updated meta-analysis, PubMed and the Cochrane Central Library database were searched through September 30, 2018, using the Medical Subject Headings and relevant search terms forcerebrovascular diseaseand forintensive BP lowering. This was a multicenter trial that included 140 hospitals in Japan; 1514 patients who had a history of stroke within the previous 3 years were approached, but 234 refused to give informed consent. Interventions In total, 1280 patients were randomized 1:1 to BP control to less than 140/90 mm Hg (standard treatment) (n = 640) or to less than 120/80 mm Hg (intensive treatment) (n = 640). However, 17 patients never received intervention; therefore, 1263 patients assigned to standard treatment (n = 630) or intensive treatment (n = 633) were analyzed. Main Outcomes and Measures The primary outcome was stroke recurrence. Results The trial was stopped early. Among 1263 analyzed patients (mean [SD] age, 67.2 [8.8] years; 69.4% male), 1257 of 1263 (99.5%) completed a mean (SD) of 3.9 (1.5) years of follow-up. The mean BP at baseline was 145.4/83.6 mm Hg. Throughout the overall follow-up period, the mean BP was 133.2/77.7 (95% CI, 132.5-133.8/77.1-78.4) mm Hg in the standard group and 126.7/77.4 (95% CI, 125.9-127.2/73.8-75.0) mm Hg in the intensive group. Ninety-one first recurrent strokes occurred. Nonsignificant rate reductions were seen for recurrent stroke in the intensive group compared with the standard group (hazard ratio [HR], 0.73; 95% CI, 0.49-1.11;P = .15). When this finding was pooled in 3 previous relevant RCTs in a meta-analysis, the risk ratio favored intensive BP control (relative risk, 0.78; 95% CI, 0.64-0.96;P = .02; absolute risk difference, −1.5%; 95% CI, −2.6% to −0.4%; number needed to treat, 67; 95% CI, 39-250). Conclusions and Relevance Intensive BP lowering tended to reduce stroke recurrence. The updated meta-analysis supports a target BP less than 130/80 mm Hg in secondary stroke prevention. Trial Registration ClinicalTrials.gov identifier:NCT01198496

Published
2019

49. Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort

Author

Nakamura, Ryoichi, Sone, Jun, Atsuta, Naoki, Tohnai, Genki, Watanabe, Hazuki, Yokoi, Daichi, Nakatochi, Masahiro, Watanabe, Hirohisa, Ito, Mizuki, Senda, Jo, Katsuno, Masahisa, Tanaka, Fumiaki, Li, Yuanzhe, Izumi, Yuishin, Morita, Mitsuya, Taniguchi, Akira, Kano, Osamu, Oda, Masaya, Kuwabara, Satoshi, Abe, Koji, Aiba, Ikuko, Okamoto, Koichi, Mizoguchi, Kouichi, Hasegawa, Kazuko, Aoki, Masashi, Hattori, Nobutaka, Tsuji, Shoji, Nakashima, Kenji, Kaji, Ryuji, and Sobue, Gen

Published
2016
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