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Your search keyword '"Ito, Kimiko"' showing total 45 results
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45 results on '"Ito, Kimiko"'

7. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

Author

Abe, Koji, Aoki, Masashi, Tsuji, Shoji, Itoyama, Yasuto, Sobue, Gen, Togo, Masanori, Hamada, Chikuma, Tanaka, Masahiko, Akimoto, Makoto, Nakamura, Kazue, Takahashi, Fumihiro, Kondo, Kazuoki, Yoshino, Hiide, Sasaki, Hidenao, Yabe, Ichiro, Doi, Shizuki, Warita, Hitoshi, Imai, Takashi, Ito, Hiroaki, Fukuchi, Mitsumasa, Osumi, Etsuko, Wada, Manabu, Nakano, Imaharu, Morita, Mitsuya, Ogata, Katsuhisa, Maruki, Yuichi, Ito, Kimiko, Kano, Osamu, Yamazaki, Mineo, Takahashi, Yuji, Ishiura, Hiroyuki, Ogino, Mieko, Koike, Ryoko, Ishida, Chiho, Uchiyama, Tsuyoshi, Mizoguchi, Kouichi, Obi, Tomokazu, Watanabe, Hirohisa, Atsuta, Naoki, Aiba, Ikuko, Taniguchi, Akira, Sawada, Hideyuki, Hazama, Takanori, Fujimura, Harutoshi, Kusaka, Hirofumi, Kunieda, Takenobu, Kikuchi, Hitoshi, Matsuo, Hidenori, Ueyama, Hidetsugu, Uekawa, Kazutoshi, Ueda, Masaki, Murakami, Aiko, Sumii, Rie, Kudou, Takuya, Morimoto, Kazunori, Yoneoka, Takatomo, Hirai, Manabu, Sasaki, Kouichi, Terai, Hidetomo, Natori, Tomoko, Matsui, Hiroshi, Kotani, Kuniko, Yoshida, Kaori, and Iwasaki, Tomohisa

Published
2017
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14. 5‐aminosalicylate–intolerant patients are at increased risk of colectomy for ulcerative colitis

Author

Hibiya, Shuji, primary, Matsuyama, Yusuke, additional, Fujii, Toshimitsu, additional, Maeyashiki, Chiaki, additional, Saito, Eiko, additional, Ito, Kimiko, additional, Shimizu, Hiromichi, additional, Kawamoto, Ami, additional, Motobayashi, Maiko, additional, Takenaka, Kento, additional, Nagahori, Masakazu, additional, Kurosaki, Masayuki, additional, Yauchi, Tsunehito, additional, Ohtsuka, Kazuo, additional, Fujiwara, Takeo, additional, Okamoto, Ryuichi, additional, and Watanabe, Mamoru, additional

Published
2020
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17. Photoinduced hydroxylation of deoxyguanosine in DNA by pterins: sequence specificity and mechanism

Author

Ito, Kimiko and Kawanishi, Shosuke

Subjects
Hydroxylation -- Research, Skin cancer -- Causes of, Radiation -- Health aspects, DNA damage -- Research, High performance liquid chromatography -- Usage, Gel electrophoresis -- Usage, DNA sequencers -- Usage, Biological sciences, Chemistry
Abstract

DNA sequencing and gel electrophoretic techniques were used to monitor pterin-mediated DNA cleavage following exposure to 365-nm of light via hydroxylation at the 5' site of 5'-GG-3' sequences of a double-stranded DNA. The findings of high performance liquid chromatography (HPLC) analysis also confirmed that pterin can cause an increase in the 8-oxo-dG content of DNA. These results provide the theoretical explanations for the relevance of sunlight exposure to the occurrence of skin cancer.

Published
1997

19. Manganese-mediated oxidative damage of cellular and isolated DNA by isoniazid and related hydrazines: non-Fenton-type hydroxyl radical formation

Author

Ito, Kimiko, Yamamoto, Koji, and Kawanishi, Shosuke

Subjects
Hydroxylation -- Research, DNA -- Research, Biological sciences, Chemistry
Abstract

A study was conducted on how hydrazines cause damage to cellular and isolated DNA when metal ions are present using pulsed-field electrophoresis, DNA sequencing methods and ESR spin-tapping. A reaction mechanism for OH formation minus a H2O2 intermediate during manganese-catalyzed hydrazine autoidation was proposed. Results also indicated the chance of hydrazines combined with Mn(II)-induced cellular DNA damage occuring via the non-Fenton-type reaction.

Published
1992

22. 5‐aminosalicylate–intolerant patients are at increased risk of colectomy for ulcerative colitis.

Author

Hibiya, Shuji, Matsuyama, Yusuke, Fujii, Toshimitsu, Maeyashiki, Chiaki, Saito, Eiko, Ito, Kimiko, Shimizu, Hiromichi, Kawamoto, Ami, Motobayashi, Maiko, Takenaka, Kento, Nagahori, Masakazu, Kurosaki, Masayuki, Yauchi, Tsunehito, Ohtsuka, Kazuo, Fujiwara, Takeo, Okamoto, Ryuichi, and Watanabe, Mamoru

Subjects
ULCERATIVE colitis, COLECTOMY, PROPORTIONAL hazards models, INFLAMMATORY bowel diseases
Abstract

Summary: Background: Although 5‐aminosalicylate (5‐ASA) is the therapy of first choice in ulcerative colitis (UC), some patients cannot tolerate it because of side effects. Previous reports have not investigated whether 5‐ASA intolerance is associated with the risk of colectomy. Aim: To investigate the associations between 5‐ASA tolerance and colectomy among UC patients Methods: The data of UC patients who visited any of three hospitals during 2014‐2018 in and around Tokyo, Japan, were retrospectively obtained from the medical records. Patients were categorized as (a) tolerant to any 5‐ASA compounds ("tolerant to 5‐ASA") and (b) patients who were intolerant to one or more 5‐ASA compounds leading to refrainment from their further use ("intolerant to 5‐ASA"). The association between 5‐ASA tolerance and colectomy was examined by Cox proportional hazards model adjusted for sex, age, smoking and extent of colitis. Results: Of 1788 patients, 1684 were "tolerant to 5‐ASA" while 104 were "intolerant to 5‐ASA". Colectomy was performed in 43 (2.6%) of the patients tolerant to 5‐ASA and 12 (11.5%) of the patients intolerant to 5‐ASA. After adjusting for all covariates, the risk of undergoing colectomy was higher in the "intolerant to 5‐ASA" group than in the "tolerant to 5‐ASA" group (hazard ratio: 4.92; 95% confidence interval: 2.58‐9.38). Conclusion: Patients in whom 5‐ASA was discontinued due to intolerance had a higher risk of undergoing colectomy than patients tolerant to their first, second or third 5‐ASA compounds. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Case of MPO-ANCA-associated glomerulonephritis with acute pancreatitis, perforated duodenal ulcer and posterior reversible encephalopathy syndrome after steroid pulse therapy

Author

Iwata, Shoko, primary, Tanahashi, Yoshihiro, additional, Tuma, Yusuke, additional, Oshima, Kazuo, additional, Manabe, Tomoko, additional, Ito, Kimiko, additional, Shikano, Hiroaki, additional, Nakashima, Yoshiki, additional, Harada, Toru, additional, Kondo, Tomio, additional, and Shigematsu, Hidekazu, additional

Published
2010
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32. Nihon Shoni Jinzobyo Gakkai Zasshi

Author

Iwata, Shoko, primary, Ozeki, Michio, additional, Ito, Kimiko, additional, Ariki, Masako, additional, Iwata, Hideki, additional, Yamazaki, Matsutaka, additional, Kondo, Tomio, additional, and Shigematsu, Hidekazu, additional

Published
2005
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45. [Different clinical phenotypes of siblings with familial amyotrophic lateral sclerosis showing Cys146Arg point mutation of superoxide dismutase 1 gene].

Author

Ito K, Uchiyama T, Fukutake T, Arai K, Kanesaka T, and Hattori T

Subjects
Amyotrophic Lateral Sclerosis physiopathology, Family Health, Female, Humans, Male, Middle Aged, Pedigree, Phenotype, Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis genetics, Point Mutation, Superoxide Dismutase genetics
Abstract

We reported different clinical phenotypes of siblings with familial amyotrophic lateral sclerosis (FALS) showing Cys146Arg point mutation of superoxide dismutase 1 (SOD1) gene. They showed differences in disease onset of age, progression and severity. The propositus, a 50-year old woman, had muscle wasting and weakness in right lower leg with dysesthesia at the onset, which showed slow progression without other neurological symptoms until 2 years after the onset when bulbar palsy appeared. She has been alive for 3.5 years after the onset. In contrast, a 61-year old man, elder brother of the propositus, had bulbar palsy at the onset, which showed rapid progression along with muscle weakness and wasting of upper extremities. Two years after the onset, he died due to respiratory failure. Detailed clinical features of FALS with Cys146Arg mutation of SOD1 have not been reported. Our cases suggest that FALS with the same SOD1 mutation could show variable clinical feature and course, and that some factors other than SOD1 mutation should be considered for the pathogenesis of FALS.

Published
2002

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