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860 results on '"Ito, Isao"'

1. Artificial intelligence-based analysis of the spatial distribution of abnormal computed tomography patterns in SARS-CoV-2 pneumonia: association with disease severity

Author

Kataoka, Yusuke, Tanabe, Naoya, Shirata, Masahiro, Hamao, Nobuyoshi, Oi, Issei, Maetani, Tomoki, Shiraishi, Yusuke, Hashimoto, Kentaro, Yamazoe, Masatoshi, Shima, Hiroshi, Ajimizu, Hitomi, Oguma, Tsuyoshi, Emura, Masahito, Endo, Kazuo, Hasegawa, Yoshinori, Mio, Tadashi, Shiota, Tetsuhiro, Yasui, Hiroaki, Nakaji, Hitoshi, Tsuchiya, Michiko, Tomii, Keisuke, Hirai, Toyohiro, and Ito, Isao

Published
2024
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2. A randomized double-blind placebo-controlled trial of an inhibitor of plasminogen activator inhibitor-1 (TM5614) in mild to moderate COVID-19

Author

Hirai, Toyohiro, Asano, Koichiro, Ito, Isao, Miyazaki, Yasunari, Sugiura, Hisatoshi, Agirbasli, Mehmet, Kobayashi, Seiichi, Kobayashi, Makoto, Shimada, Daishi, Natsume, Ichiro, Kawasaki, Tsutomu, Ohba, Takehiko, Tajiri, Sakurako, Sakamaki, Fumio, Mineshita, Masamichi, Takihara, Takahisa, Sekiya, Kiyoshi, Tomii, Keisuke, Tomioka, Hiromi, Kita, Hideo, Nishizaka, Yasuo, Fukui, Motonari, Miyata, Toshio, and Harigae, Hideo

Published
2024
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3. Jitter correction for asynchronous optical sampling terahertz spectroscopy using free-running pulsed lasers

Author

Nakagawa, Mayuri, Kanda, Natsuki, Otsu, Toshio, Ito, Isao, Kobayashi, Yohei, and Matsunaga, Ryusuke

Subjects
Physics - Optics
Abstract

We demonstrate a jitter correction method for asynchronous optical sampling (ASOPS) terahertz (THz) time-domain spectroscopy using two free-running oscillators. This method simultaneously records the THz waveform and a harmonic of the laser repetition rate difference, to monitor the jitter information for software jitter correction. By suppressing the residual jitter below 0.1 ps, the accumulation of the THz waveform is achieved without losing the measurement bandwidth. Our measurement of water vapor successfully resolves the absorption linewidths below 1 GHz, demonstrating a robust ASOPS with a flexible, simple, and compact setup without any feedback control or additional continuous-wave THz source., Comment: 18 pages, 5 figures

Published
2023
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16. Comparison of chest radiological findings between coronavirus disease 2019 pneumonia and anti-melanoma differentiation-associated gene 5 antibody- positive interstitial pneumonia by artificial intelligence-based quantitative computed tomography image analysis

Author

Hamao, Nobuyoshi, primary, Ito, Isao, additional, Yamazoe, Masatoshi, additional, Hasegawa, Yoshinori, additional, Yamamoto, Shungo, additional, Emura, Masahito, additional, Endo, Kazuo, additional, Hirabayashi, Masataka, additional, Tanabe, Naoya, additional, Tanizawa, Kiminobu, additional, Handa, Tomohiro, additional, Nakashima, Ran, additional, Oi, Issei, additional, Shirata, Masahiro, additional, Nishioka, Kensuke, additional, and Hirai, Toyohiro, additional

Published
2023
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19. Unmarked R2 manuscript Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap

Author

Morimoto, Chie, primary, Matsumoto, Hisako, additional, Nomura, Natsuko, additional, Sunadome, Hironobu, additional, Nagasaki, Tadao, additional, Sato, Susumu, additional, Sato, Atsuyasu, additional, Oguma, Tsuyoshi, additional, Ito, Isao, additional, Kogo, Mariko, additional, Tomii, Keisuke, additional, Tajiri, Tomoko, additional, Ohashi, Kai, additional, Tsukahara, Takamitsu, additional, and Hirai, Toyohiro, additional

Published
2023
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25. Pharmacokinetics of GS-441524, the active metabolite of remdesivir, in patients receiving continuous renal replacement therapy: A case series.

Author

Nishikawa, Asami, Ito, Isao, Yonezawa, Atsushi, Itohara, Kotaro, Matsubara, Takeshi, Sato, Yuki, Matsumura, Katsuyuki, Hamada, Satoshi, Tanabe, Naoya, Kai, Shinichi, Imoto, Eishi, Yoshikawa, Kohei, Ohtsuru, Shigeru, Yanagita, Motoko, Hirai, Toyohiro, and Terada, Tomohiro

Subjects
*RENAL replacement therapy, *CORONAVIRUS disease treatment, *REMDESIVIR, *COVID-19, *PHARMACOKINETICS
Abstract

Remdesivir plays a key role in the treatment of coronavirus disease in 2019 (COVID-19). Haemodialysis is sometimes required for hospitalised patients with COVID-19, and patients undergoing haemodialysis are at an increased risk of severe COVID-19. In the present study, we report the serum concentrations of GS-441524, the active metabolite of remdesivir, in four patients undergoing continuous renal replacement therapy (CRRT). Patient 1, a male aged 70s, received a loading dose of 200 mg remdesivir on day 1, followed by 100 mg remdesivir from day 2, according to the package insert as in non-haemodialysis patients. The mean trough serum concentration of GS-441524 was 783.5 ng/mL, which was approximately 7-fold higher than the mean for patients with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min. Patients 2-4 received a loading dose of 200 mg remdesivir on day 1, followed by 100 mg once every 2 days from day 2. The mean trough serum concentrations of GS-441524 were 302.2 ng/mL, 585.8 ng/mL and 677.3 ng/mL, respectively. These were 3 to 6-fold higher than the mean for patients with eGFR ≥60 mL/min. The target doses for patients 1, 2, 3, and 4 receiving CRRT were 13.6 mL/kg/h, 6.0–12.5 mL/kg/h, 20.1 mL/kg/h, and 15.1 mL/kg/h, respectively, using a polysulphone membrane. The package insert dose of remdesivir is an overdose for CRRT patients with a target dose of 10–20 mL/kg/h. In low-intensity CRRT, as in Japan, it may be necessary to extend the interval between the doses of remdesivir. [ABSTRACT FROM AUTHOR]

Published
2024
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27. A case of immunoglobulin G4–related retroperitoneal fibrosis and hypophysitis with antecedent respiratory disease followed by spontaneous remission and recurrence

Author

Sakai, Masato, primary, Ohno, Yuta, additional, Kozuki, Nana, additional, Kawasaki, Yuki, additional, Yoshida, Michiko, additional, Ikeda, Hiroyuki, additional, Konishi, Junji, additional, Maeda, Toshiki, additional, Sugano, Motoki, additional, Kawakami, Satoshi, additional, Ito, Isao, additional, Yamaguchi, Aina, additional, Naiki, Hironobu, additional, Notohara, Kenji, additional, Akamizu, Takashi, additional, Kawano, Mitsuhiro, additional, and Yoshida, Haruyoshi, additional

Published
2023
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33. Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes

Author

Matsumoto, Hisako, Kanemitsu, Yoshihiro, Nagasaki, Tadao, Tohda, Yuji, Horiguchi, Takahiko, Kita, Hideo, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Tomita, Katsuyuki, Yokoyama, Akihito, Ohnishi, Hiroshi, Nakano, Yasutaka, Oguma, Tetsuya, Hozawa, Soichiro, Izuhara, Yumi, Ito, Isao, Oguma, Tsuyoshi, Inoue, Hideki, Tajiri, Tomoko, Iwata, Toshiyuki, Ono, Junya, Ohta, Shoichiro, Hirota, Tomomitsu, Kawaguchi, Takahisa, Tamari, Mayumi, Yokoyama, Tetsuji, Tabara, Yasuharu, Matsuda, Fumihiko, Izuhara, Kenji, Niimi, Akio, and Mishima, Michiaki

Published
2017
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35. A case of immunoglobulin G4–related retroperitoneal fibrosis and hypophysitis with antecedent respiratory disease followed by spontaneous remission and recurrence.

Author

Sakai, Masato, Ohno, Yuta, Kozuki, Nana, Kawasaki, Yuki, Yoshida, Michiko, Ikeda, Hiroyuki, Konishi, Junji, Maeda, Toshiki, Sugano, Motoki, Kawakami, Satoshi, Ito, Isao, Yamaguchi, Aina, Naiki, Hironobu, Notohara, Kenji, Akamizu, Takashi, Kawano, Mitsuhiro, and Yoshida, Haruyoshi

Subjects
RETROPERITONEAL fibrosis, RESPIRATORY diseases, THERAPEUTICS, BLOOD cell count, LEUCOCYTES, PULMONARY fibrosis
Published
2024
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38. Factors associated with the development of bacterial pneumonia related to seasonal influenza virus infection: a study using a large-scale health insurance claim database

Author

Shirata, Masahiro, primary, Ito, Isao, additional, Jo, Taisuke, additional, Iwao, Tomohide, additional, Oi, Issei, additional, Hamao, Nobuyoshi, additional, Nishioka, Kensuke, additional, Yamana, Hayato, additional, Nagase, Takahide, additional, Yasunaga, Hideo, additional, and Hirai, Toyohiro, additional

Published
2023
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44. Protein C activity as a potential prognostic factor for nursing home-acquired pneumonia

Author

Oi, Issei, primary, Ito, Isao, additional, Tanabe, Naoya, additional, Konishi, Satoshi, additional, Hamao, Nobuyoshi, additional, Shirata, Masahiro, additional, Imai, Seiichiro, additional, Yasutomo, Yoshiro, additional, Kadowaki, Seizo, additional, Matsumoto, Hisako, additional, Hidaka, Yu, additional, Morita, Satoshi, additional, and Hirai, Toyohiro, additional

Published
2022
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46. QT Prolongation in Dialysis Patients: An Epidemiological Study with a Focus on Malnutrition.

Author

Shibata, Masanori, Ito, Isao, Tawada, Hisae, and Taniguchi, Shinkichi

Subjects
*HEMODIALYSIS patients, *ARRHYTHMIA, *VENTRICULAR fibrillation, *BODY composition, *MUSCLE mass, *CARDIAC arrest
Abstract

Background/Aims: QT prolongation is a known risk factor for ventricular fibrillation and ventricular tachycardia. Therefore, more refined management is necessary to reduce sudden cardiac death secondary to such arrhythmias. Methods: Electrocardiographic findings were reviewed in 224 patients, and the associations of QT prolongation with various clinical parameters were examined, including the nutritional state. Correlations were also examined between QT prolongation and body composition measurements determined by multifrequency bioelectrical impedance analysis. Results: Prolongation of the corrected QT (QTc) interval over 0.44 s was seen in 140 patients (62.5%). QT prolongation was independent of age and dialysis therapy duration and was more frequent in diabetics (70.1%) than in nondiabetics (54.2%, p = 0.014) and more frequent in women (78.8%) than in men (53.5%, p < 0.001). Serum levels of albumin (p < 0.001) and Cr (p < 0.001) and the Geriatric Nutritional Risk Index (GNRI, p < 0.001) were negatively correlated with QTc interval; no significant correlation was noted with total protein, urea nitrogen, or uric acid. Negative correlations with QTc interval were found for BMI(p < 0.01), percent total body water (%TBW; p < 0.05), and percent intracellular water (%ICW; p < 0.01) but not with the percent extracellular water/TBW ratio or edema ratio. The longer the QTc interval, the lower the fat-free mass (FFM; p < 0.01) and muscle mass (MM; p < 0.01), but there was no significant correlation with percent fat. Conclusion: These results suggest that QT prolongation is a common complication and is more frequent in women and diabetic patients. The decreases in serum albumin and Cr levels, GNRI, BMI, %TBW, %ICW, FFM, and MM together coincided with malnutrition and thus suggest a close relationship of QT prolongation with malnutrition. Management of QT prolongation may be achieved better in the future by understanding these biochemical and biophysical changes, particularly those regarding malnutrition. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Cumulative C-Reactive Protein Levels and Progression of Malnutrition in Dialysis Patients: A Longitudinal Study.

Author

Asai, Kazuaki, Shibata, Masanori, Ito, Isao, Tawada, Hisae, and Taniguchi, Shinkichi

Subjects
HEMODIALYSIS patients, C-reactive protein, LDL cholesterol, MALNUTRITION, LONGITUDINAL method
Abstract

Background/Aims: Malnutrition is a serious complication in dialysis patients that develops slowly but steadily. Cross-sectional studies may not adequately characterize this complication because not only the intensity but longitudinally cumulative effect should also be taken into consideration. Relationship between time-dependent changes in a nutritional marker, Geriatric Nutritional Risk Index (GNRI), and cumulative C-reactive protein (CRP) values was examined whether both intensity and duration of inflammation correlated with time-dependent progression and severity of malnutrition over 3 years, retrospectively. Methods: One hundred and sixty-four dialysis patients were examined over 3 years retrospectively. Based on analysis of clinical and laboratory findings over a period of 3 years, patients were divided into 2 groups: those with a >3.0 decrease in GNRI after 3 years (n = 84) and those in whom GNRI was unchanged (n = 80). Results: When comparing the 2 groups at 3 years, the GNRI-decreased group had 12% lower serum albumin (p < 0.001) and lower levels of creatinine (9%, p < 0.001), BUN (6%, p < 0.05), total cholesterol (6%, p < 0.05), and low-density lipoprotein cholesterol (10%, p < 0.01), which suggest onset of malnutrition. CRP levels, routinely measured twice a month in all patients, were summed to calculate the cumulative CRP. Cumulative CRP after 3 years was 57.6 ± 7.8 (mg/dL/3 years) in the GNRI-decreased group, which was significantly higher than that in the GNRI-unchanged group (38.6 ± 3.9; p < 0.05). Over 3 years, the GNRI-decreased group showed a time-dependent increase in cumulative CRP alongside a time-dependent decrease in the GNRI, producing an obvious mirror image; however, such inverse correlation was absent in the GNRI-unchanged group. Conclusion: A long-term perspective is needed in the management of malnutrition in dialysis patients because this complication develops progressively and is often irreversible when diagnosed. Cumulative CRP values may be useful in evaluating the degree of the progression of malnutrition in following up individual patients longitudinally. [ABSTRACT FROM AUTHOR]

Published
2023
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