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350 results on '"Itatani, Yoshiro"'

7. Impact of the coronavirus disease 2019 pandemic on gastric and colorectal cancer surgeries: a multicenter epidemiologic study from the Kinki region of Japan

Author

Jikihara, Shunpei, Hoshino, Nobuaki, Hida, Koya, Inamoto, Susumu, Tanaka, Eiji, Matsusue, Ryo, Hamasu, Shinya, Matsuo, Koichi, Hashida, Hiroki, Shiota, Tetsuya, Yamada, Masahiro, Yamashita, Yoshito, Nakamura, Yuya, Yoshitomi, Mami, Murakami, Teppei, Itatani, Yoshiro, Hisamori, Shigeo, Tsunoda, Shigeru, and Obama, Kazutaka

Published
2024
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9. Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage

Author

Hirata, Wataru, Itatani, Yoshiro, Masui, Hideyuki, Kawada, Kenji, Mizuno, Rei, Yamamoto, Takamasa, Okamoto, Takuya, Ogawa, Ryotaro, Inamoto, Susumu, Maekawa, Hisatsugu, Okamura, Ryosuke, Kiyasu, Yoshiyuki, Hanada, Keita, Okamoto, Michio, Nishikawa, Yasuyo, Sugimoto, Naoko, Tamura, Takuya, Hatano, Etsuro, Sakai, Yoshiharu, and Obama, Kazutaka

Published
2023
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12. Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer

Author

Itatani, Yoshiro, Yamamoto, Takamasa, Zhong, Cuiling, Molinolo, Alfredo A, Ruppel, Jane, Hegde, Priti, Taketo, M Mark, and Ferrara, Napoleone

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Colo-Rectal Cancer, Digestive Diseases, Aetiology, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Angiogenesis Inducing Agents, Animals, Antibodies, Colonic Neoplasms, Colorectal Neoplasms, Female, Granulocyte Colony-Stimulating Factor, Liver Neoplasms, Male, Mice, Mice, Inbred C57BL, Models, Genetic, Myeloid Cells, Neovascularization, Pathologic, Neutrophils, Vascular Endothelial Growth Factor A, colorectal cancer, angiogenesis, inflammation, myeloid cells, drug resistance
Abstract

We tested cis-ApcΔ716/Smad4+/- and cis-ApcΔ716/Smad4+/-KrasG12D mice, which recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis in humans, for responsiveness to anti-VEGF therapy. We found that even tumors in cis-ApcΔ716/Smad4+/-KrasG12D mice, although highly aggressive, were suppressed by anti-VEGF treatment. We tested the hypothesis that inflammation, a major risk factor and trigger for CRC, may affect responsiveness to anti-VEGF. Chemically induced colitis (CIC) in cis-ApcΔ716/Smad4+/- and cis-ApcΔ716/Smad4+/-KrasG12D mice promoted development of colon tumors that were largely resistant to anti-VEGF treatment. The myeloid growth factor G-CSF was markedly increased in the serum after induction of colitis. Antibodies blocking G-CSF, or its target Bv8/PROK2, suppressed tumor progression and myeloid cell infiltration when combined with anti-VEGF in CIC-associated CRC and in anti-VEGF-resistant CRC liver metastasis models. In a series of CRC specimens, tumor-infiltrating neutrophils strongly expressed Bv8/PROK2. CRC patients had significantly higher plasma Bv8/PROK2 levels than healthy volunteers and high plasma Bv8/PROK2 levels were inversely correlated with overall survival. Our findings establish Bv8/PROK2 as a translational target in CRC, in combination with anti-VEGF agents.

Published
2020

15. Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment.

Author

Lin, Yi‐Kai, Coppo, Roberto, Onuma, Kunishige, Endo, Hiroko, Kondo, Jumpei, Iwabuchi, Sadahiro, Hashimoto, Shinichi, Itatani, Yoshiro, Obama, Kazutaka, and Inoue, Masahiro

Abstract

Cancer cell clusters have a higher capacity for metastasis than single cells, suggesting cancer cell clusters have biological properties different from those of single cells. The nature of de novo cancer cell clusters that are newly formed from tumor masses is largely unknown. Herein, we generated small cell clusters from colorectal cancer organoids and tracked the growth patterns of the clusters up to four cells. Growth patterns were classified into actively growing and poorly growing spheroids (PG). Notch signaling was robustly activated in small clusters immediately after dissociation, and Notch signaling inhibition markedly increased the proportion of PG spheroids. Only a limited number of PG spheroids grew under growth‐permissive conditions in vitro, but xenograft tumors derived from Notch inhibited clusters showed growth rates comparable to those of untreated spheroids. Thus, de novo clusters are composed of cells with interchangeable growth fates, which are regulated in a context‐dependent manner by Notch signaling. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Low‐grade appendiceal mucinous neoplasm penetrating sigmoid colon: A case report.

Author

Okamoto, Michio, Okamura, Ryosuke, Itatani, Yoshiro, Aisu, Yuki, Kinoshita, Hiromitsu, Hoshino, Nobuaki, Maekawa, Hisatsugu, Sakamoto, Takashi, Kasahara, Keiko, Okumura, Shintaro, Nishigori, Tatsuto, Hisamori, Shigeo, Tsunoda, Shigeru, Hida, Koya, Nikaido, Mitsuhiro, Hiramatsu, Yukiko, Teramoto, Yuki, Nagayama, Satoshi, and Obama, Kazutaka

Subjects
SIGMOID colon, LAPAROSCOPIC surgery, ENDOSCOPIC surgery, SURGERY, APPENDIX (Anatomy)
Abstract

Low‐grade appendiceal mucinous neoplasm (LAMN) is principally characterized by low‐grade cytology without evidence of invasion to other organs. We report a LAMN surgical case whose appendiceal tumor penetrated the sigmoid colon wall. An 87‐year‐old man was referred for endoscopic resection (ER) of a colon polyp. Despite four ERs over 5 years, the polyp recurred at the same site. Laparoscopic surgery revealed a dilated appendix firmly attached to the sigmoid colon. We performed en bloc resection of both the sigmoid colon and appendix without tumor exposure. The histopathological evaluation showed that the LAMN had penetrated the sigmoid colon wall, forming two polyps on the colonic mucosa. In cases where the appendiceal‐colonic fistula is suspected, en bloc resection of the appendix and colon wall should be considered. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

Author

Okumura, Shintaro, Konishi, Yusuke, Narukawa, Megumi, Sugiura, Yuki, Yoshimoto, Shin, Arai, Yuriko, Sato, Shintaro, Yoshida, Yasuo, Tsuji, Shunya, Uemura, Ken, Wakita, Masahiro, Matsudaira, Tatsuyuki, Matsumoto, Tomonori, Kawamoto, Shimpei, Takahashi, Akiko, Itatani, Yoshiro, Miki, Hiroaki, Takamatsu, Manabu, Obama, Kazutaka, Takeuchi, Kengo, Suematsu, Makoto, Ohtani, Naoko, Fukunaga, Yosuke, Ueno, Masashi, Sakai, Yoshiharu, Nagayama, Satoshi, and Hara, Eiji

Published
2021
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22. Articulating forceps in laparoscopic total mesorectal excision: A video comparison with robotic surgery.

Author

Masui, Hideyuki, Itatani, Yoshiro, Hoshino, Nobuaki, Okamura, Ryosuke, Nishigori, Tatsuto, Hisamori, Shigeo, Tsunoda, Shigeru, Hida, Koya, and Obama, Kazutaka

Abstract

Introduction: Total mesorectal excision (TME) is an established standard procedure for rectal surgery; however, it is technically challenging because of the deep and narrow pelvis. Minimally invasive surgeries have gained prominence for TME with favorable outcomes but come with limitations. Laparoscopic surgery often has dexterity restrictions because of the use of straight forceps, whereas robotic surgery is impeded by high costs and extended operative times. Articulating forceps aim to bridge the gap between these methods by offering enhanced dexterity at a lower cost. Patients and Surgical Technique: This video study involves two female patients diagnosed with lower rectal cancer. One patient underwent laparoscopic intersphincteric resection (Lap‐ISR) using the ArtiSential articulating forceps (LIVSMED Inc.), and the other underwent robot‐assisted low anterior resection (Rob‐LAR) using the da Vinci Xi System. Both operations involved similar mesorectal dissection steps, except for the anastomosis. The standard port placement was used, and dissection was performed circumferentially down to the perianal region. Discussion: The ArtiSential demonstrated effectiveness comparable with the da Vinci Xi system in TME surgery, with the potential advantage of improved cost‐effectiveness. [ABSTRACT FROM AUTHOR]

Published
2024
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25. 371. THE FEASIBILITY OF MINIMALLY INVASIVE SALVAGE ESOPHAGECTOMY

Author

Tsunoda, Shigeru, primary, Nishigori, Tatsuto, additional, Hisamori, Shigeo, additional, Okumura, Shintaro, additional, Maekawa, Hisatsugu, additional, Fujita, Yusuke, additional, Kasahara, Keiko, additional, Morimoto, Tomonori, additional, Kinoshita, Hiromitsu, additional, Sakamoto, Takashi, additional, Mihara, Kaito, additional, Okamura, Ryosuke, additional, Itatani, Yoshiro, additional, Hoshino, Nobuaki, additional, Hida, Koya, additional, and Obama, Kazutaka, additional

Published
2023
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26. Impact of the coronavirus disease 2019 pandemic on gastric and colorectal cancer surgeries: a multicenter epidemiologic study from the Kinki region of Japan

Author

Jikihara, Shunpei, primary, Hoshino, Nobuaki, additional, Hida, Koya, additional, Inamoto, Susumu, additional, Tanaka, Eiji, additional, Matsusue, Ryo, additional, Hamasu, Shinya, additional, Matsuo, Koichi, additional, Hashida, Hiroki, additional, Shiota, Tetsuya, additional, Yamada, Masahiro, additional, Yamashita, Yoshito, additional, Nakamura, Yuya, additional, Yoshitomi, Mami, additional, Murakami, Teppei, additional, Itatani, Yoshiro, additional, Hisamori, Shigeo, additional, Tsunoda, Shigeru, additional, and Obama, Kazutaka, additional

Published
2023
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27. Anal Gland Adenocarcinoma with Pagetoid Spread: A Case Report

Author

Chikamori, Kentaro, Okada, Tomoaki, Kawada, Kenji, Yamada, Yosuke, Okamura, Ryosuke, Itatani, Yoshiro, Hida, Koya, and Obama, Kazutaka

Subjects
anal gland adenocarcinoma, Pagetoid spread, 肛門腺癌, rectal cancer, 直腸癌
Abstract

肛門周囲の上皮内に隣接臓器癌が進展しPaget病様の組織像を呈する現象をPagetoid spreadと呼ぶ．症例は84歳の女性で，主訴は肛門周囲の発赤であった．内視鏡で直腸癌を認め，肛門周囲皮膚の生検と免疫染色検査の結果から直腸癌由来のPagetoid spreadが考えられ，ロボット支援下直腸切断術と肛門周囲皮膚切除術を施行した．病理学的検討では肛門皮膚病変は直腸癌と連続しておらず，直腸癌とは別に肛門腺癌を認め，また肛門皮膚病変の免疫染色検査のプロファイルが直腸癌と一致せず，肛門腺癌と一致したため，肛門腺癌由来のPagetoid spreadと最終診断した．肛門腺癌はまれで，粘膜に病変を認めにくく，初期の発見は困難である．肛門周囲にPaget細胞を認めた場合，肛門腺癌によるPagetoid spreadの可能性を念頭に置き，免疫染色検査を含めた詳細な病理学的検討を行うことが重要である．, An 84-year-old woman presented with perianal skin redness. Histopathological examination of skin biopsy revealed Paget’s cells, and colonoscopy indicated rectal cancer. Thus, pagetoid spread of rectal cancer was diagnosed. Robot-assisted abdominoperineal resection of the perineal skin lesion was performed. A further histopathological examination revealed that Paget’s cells were not contiguous with rectal cancer cells, and anal gland adenocarcinoma was thus identified. The immunohistochemical staining pattern of the pagetoid spread (CK20+/CK7+) was consistent with that of the anal gland adenocarcinoma (CK20+/CK7+), rather than with the rectal cancer (CK20+/CK7–). Therefore, we ultimately diagnosed pagetoid spread of anal gland adenocarcinoma. Anal gland adenocarcinoma is rare and difficult to detect in the early stage because the lesion is not exposed on the mucosal surface. Since anal gland adenocarcinoma was latent in the present case, a detailed immunohistopathological examination was necessary to diagnose the origin of the perineal Pagetoid spread accurately.

Published
2022

39. Supplementary Figure 2 from Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis

Author

Yamamoto, Takamasa, primary, Kawada, Kenji, primary, Itatani, Yoshiro, primary, Inamoto, Susumu, primary, Okamura, Ryosuke, primary, Iwamoto, Masayoshi, primary, Miyamoto, Ei, primary, Chen-Yoshikawa, Toyofumi F., primary, Hirai, Hideyo, primary, Hasegawa, Suguru, primary, Date, Hiroshi, primary, Taketo, Makoto M., primary, and Sakai, Yoshiharu, primary

Published
2023
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40. Supplementary Figure 2 from Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15–CCR1 Chemokine Axis

Author

Inamoto, Susumu, primary, Itatani, Yoshiro, primary, Yamamoto, Takamasa, primary, Minamiguchi, Sachiko, primary, Hirai, Hideyo, primary, Iwamoto, Masayoshi, primary, Hasegawa, Suguru, primary, Taketo, Makoto Mark, primary, Sakai, Yoshiharu, primary, and Kawada, Kenji, primary

Published
2023
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41. Supplemental material and methods from Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15–CCR1 Chemokine Axis

Author

Inamoto, Susumu, primary, Itatani, Yoshiro, primary, Yamamoto, Takamasa, primary, Minamiguchi, Sachiko, primary, Hirai, Hideyo, primary, Iwamoto, Masayoshi, primary, Hasegawa, Suguru, primary, Taketo, Makoto Mark, primary, Sakai, Yoshiharu, primary, and Kawada, Kenji, primary

Published
2023
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42. Supplementary information from Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis

Author

Yamamoto, Takamasa, primary, Kawada, Kenji, primary, Itatani, Yoshiro, primary, Inamoto, Susumu, primary, Okamura, Ryosuke, primary, Iwamoto, Masayoshi, primary, Miyamoto, Ei, primary, Chen-Yoshikawa, Toyofumi F., primary, Hirai, Hideyo, primary, Hasegawa, Suguru, primary, Date, Hiroshi, primary, Taketo, Makoto M., primary, and Sakai, Yoshiharu, primary

Published
2023
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43. Supplementary Figure 4 from Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis

Author

Yamamoto, Takamasa, primary, Kawada, Kenji, primary, Itatani, Yoshiro, primary, Inamoto, Susumu, primary, Okamura, Ryosuke, primary, Iwamoto, Masayoshi, primary, Miyamoto, Ei, primary, Chen-Yoshikawa, Toyofumi F., primary, Hirai, Hideyo, primary, Hasegawa, Suguru, primary, Date, Hiroshi, primary, Taketo, Makoto M., primary, and Sakai, Yoshiharu, primary

Published
2023
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46. Supplementary Figure 1 from Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis

Author

Yamamoto, Takamasa, primary, Kawada, Kenji, primary, Itatani, Yoshiro, primary, Inamoto, Susumu, primary, Okamura, Ryosuke, primary, Iwamoto, Masayoshi, primary, Miyamoto, Ei, primary, Chen-Yoshikawa, Toyofumi F., primary, Hirai, Hideyo, primary, Hasegawa, Suguru, primary, Date, Hiroshi, primary, Taketo, Makoto M., primary, and Sakai, Yoshiharu, primary

Published
2023
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47. Supplementary Figure 3 from Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15–CCR1 Chemokine Axis

Author

Inamoto, Susumu, primary, Itatani, Yoshiro, primary, Yamamoto, Takamasa, primary, Minamiguchi, Sachiko, primary, Hirai, Hideyo, primary, Iwamoto, Masayoshi, primary, Hasegawa, Suguru, primary, Taketo, Makoto Mark, primary, Sakai, Yoshiharu, primary, and Kawada, Kenji, primary

Published
2023
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48. Supplementary Figure 6 from Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis

Author

Yamamoto, Takamasa, primary, Kawada, Kenji, primary, Itatani, Yoshiro, primary, Inamoto, Susumu, primary, Okamura, Ryosuke, primary, Iwamoto, Masayoshi, primary, Miyamoto, Ei, primary, Chen-Yoshikawa, Toyofumi F., primary, Hirai, Hideyo, primary, Hasegawa, Suguru, primary, Date, Hiroshi, primary, Taketo, Makoto M., primary, and Sakai, Yoshiharu, primary

Published
2023
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49. Supplemental Tables from Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15–CCR1 Chemokine Axis

Author

Inamoto, Susumu, primary, Itatani, Yoshiro, primary, Yamamoto, Takamasa, primary, Minamiguchi, Sachiko, primary, Hirai, Hideyo, primary, Iwamoto, Masayoshi, primary, Hasegawa, Suguru, primary, Taketo, Makoto Mark, primary, Sakai, Yoshiharu, primary, and Kawada, Kenji, primary

Published
2023
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50. Supplementary Figure 4 from Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15–CCR1 Chemokine Axis

Author

Inamoto, Susumu, primary, Itatani, Yoshiro, primary, Yamamoto, Takamasa, primary, Minamiguchi, Sachiko, primary, Hirai, Hideyo, primary, Iwamoto, Masayoshi, primary, Hasegawa, Suguru, primary, Taketo, Makoto Mark, primary, Sakai, Yoshiharu, primary, and Kawada, Kenji, primary

Published
2023
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