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44 results on '"Itagaki, Ryo"'

1. Robust Zero Modes in Disordered Two-Dimensional Honeycomb Lattice with Kekul\'e Bond Ordering

Author

Kawarabayashi, Tohru, Inoue, Yuya, Itagaki, Ryo, Hatsugai, Yasuhiro, and Aoki, Hideo

Subjects
Condensed Matter - Disordered Systems and Neural Networks
Abstract

Robustness of zero-modes of two-dimensional Dirac fermions is examined numerically for the honeycomb lattice in the presence of Kekul\'e bond ordering. The split $n=0$ Landau levels in a magnetic field as well as the zero-modes generated by topological defects in the Kekul\'e ordering are shown to exhibit anomalous robustness against disorder when the chiral symmetry is respected., Comment: 11 pages, 9 figures, submitted to the proceedings of Localisation 2020

Published
2021
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2. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

Author

Deuse, Tobias, Hua, Xiaoqin, Wang, Dong, Maegdefessel, Lars, Heeren, Joerg, Scheja, Ludger, Bolaños, Juan P, Rakovic, Aleksandar, Spin, Joshua M, Stubbendorff, Mandy, Ikeno, Fumiaki, Länger, Florian, Zeller, Tanja, Schulte-Uentrop, Leonie, Stoehr, Andrea, Itagaki, Ryo, Haddad, Francois, Eschenhagen, Thomas, Blankenberg, Stefan, Kiefmann, Rainer, Reichenspurner, Hermann, Velden, Joachim, Klein, Christine, Yeung, Alan, Robbins, Robert C, Tsao, Philip S, and Schrepfer, Sonja

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Prevention, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Cardiovascular, Angioplasty, Balloon, Animals, Aorta, Apoptosis, Arteries, Cell Proliferation, Constriction, Pathologic, Coronary Vessels, Dichloroacetic Acid, Disease Models, Animal, Enzyme Activation, Gene Knockdown Techniques, Humans, Hyperplasia, Iliac Artery, Mammary Arteries, Membrane Potential, Mitochondrial, Mitochondria, Heart, Myocytes, Smooth Muscle, Protein Serine-Threonine Kinases, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Rabbits, Rats, Secondary Prevention, Stents, Swine, Tunica Intima, Protein-Serine-Threonine Kinases, General Science & Technology
Abstract

Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States. In-stent restenosis and bypass graft failure are characterized by excessive smooth muscle cell (SMC) proliferation and concomitant myointima formation with luminal obliteration. Here we show that during the development of myointimal hyperplasia in human arteries, SMCs show hyperpolarization of their mitochondrial membrane potential (ΔΨm) and acquire a temporary state with a high proliferative rate and resistance to apoptosis. Pyruvate dehydrogenase kinase isoform 2 (PDK2) was identified as a key regulatory protein, and its activation proved necessary for relevant myointima formation. Pharmacologic PDK2 blockade with dichloroacetate or lentiviral PDK2 knockdown prevented ΔΨm hyperpolarization, facilitated apoptosis and reduced myointima formation in injured human mammary and coronary arteries, rat aortas, rabbit iliac arteries and swine (pig) coronary arteries. In contrast to several commonly used antiproliferative drugs, dichloroacetate did not prevent vessel re-endothelialization. Targeting myointimal ΔΨm and alleviating apoptosis resistance is a novel strategy for the prevention of proliferative vascular diseases.

Published
2014

12. Limbicuspidalization of the Native Tricuspid Aortic Valve: A Porcine in Vivo Model of Bicuspid Aortopathy

Author

Kimura, Naoyuki, primary, Itagaki, Ryo, additional, Nakamura, Masanori, additional, Tofrizal, Alimuddin, additional, Yatabe, Megumi, additional, Yoshizaki, Takamichi, additional, Kokubo, Ryo, additional, Hishikawa, Shuji, additional, Kunita, Satoshi, additional, Adachi, Hideo, additional, Misawa, Yoshio, additional, Yashiro, Takashi, additional, and Kawahito, Koji, additional

Published
2022
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19. Common carotid artery true lumen flow impairment in patients with type A aortic dissection

Author

Kreibich, Maximilian, primary, Desai, Nimesh D, additional, Bavaria, Joseph E, additional, Szeto, Wilson Y, additional, Vallabhajosyula, Prashanth, additional, Beyersdorf, Friedhelm, additional, Czerny, Martin, additional, Siepe, Matthias, additional, Rylski, Bartosz, additional, Itagaki, Ryo, additional, Okamura, Homare, additional, Yamaguchi, Atsushi, additional, and Kimura, Naoyuki, additional

Published
2020
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21. Preoperative neurological deficit in acute type A aortic dissection

Author

Kreibich, Maximilian, primary, Desai, Nimesh D, primary, Bavaria, Joseph E, primary, Szeto, Wilson Y, primary, Vallabhajosyula, Prashanth, primary, Itagaki, Ryo, primary, Okamura, Homare, primary, Kimura, Naoyuki, primary, Yamaguchi, Atsushi, primary, Beyersdorf, Friedhelm, primary, Czerny, Martin, primary, and Rylski, Bartosz, primary

Published
2020
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24. Impact of Carotid Artery Involvement in Type A Aortic Dissection

Author

Kreibich, Maximilian, primary, Rylski, Bartosz, additional, Czerny, Martin, additional, Beyersdorf, Friedhelm, additional, Itagaki, Ryo, additional, Okamura, Homare, additional, Kimura, Naoyuki, additional, Yamaguchi, Atsushi, additional, Vallabhajosyula, Prashanth, additional, Szeto, Wilson Y., additional, Bavaria, Joseph E., additional, and Desai, Nimesh D., additional

Published
2019
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28. Common carotid artery true lumen flow impairment in patients with type A aortic dissection.

Author

Kreibich, Maximilian, Desai, Nimesh D, Bavaria, Joseph E, Szeto, Wilson Y, Vallabhajosyula, Prashanth, Beyersdorf, Friedhelm, Czerny, Martin, Siepe, Matthias, Rylski, Bartosz, Itagaki, Ryo, Okamura, Homare, Yamaguchi, Atsushi, and Kimura, Naoyuki

Subjects
AORTIC dissection, CAROTID artery, HOSPITAL mortality, BLOOD flow, STROKE patients, HUMAN dissection
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Our aim was to evaluate clinical and neurological effects of common carotid artery (CCA) true lumen flow impairment or occlusion in patients with type A aortic dissection. METHODS Characteristics and imaging data of patients with dissected CCA secondary to acute type A aortic dissection from 3 institutions were analysed. We defined true lumen blood flow as unimpaired when the maximum true lumen diameter exceeded 50% of the complete CCA diameter, as impaired when the true lumen was compressed to ˃50% of the complete lumen, or as occluded. RESULTS Out of 440 patients, 207 presented unimpaired CCA flow, 172 impaired CCA flow and CCA occlusion was present in 61 patients. Preoperative shock (P  = 0.045) or a neurological deficit (P  < 0.001) were least common in patients with unimpaired CCA flow and most common in those with CCA occlusion. Non-cerebral, other-organ malperfusion was common in 37% of all patients, but the incidence was similar (P  = 0.69). In patients with CCA occlusion, postoperative stroke (P  < 0.001) and in-hospital mortality (0.011) were significantly higher, while the incidences were similar between patients with unimpaired and impaired CCA flow. Mixed-effects logistic regression models showed that CCA flow impairment (P  = 0.23) or occlusion (P  = 0.55) was not predictive for in-hospital mortality, but CCA occlusion was predictive for in-hospital stroke (odds ratio 2.166, P  = 0.023) CONCLUSIONS Shock and non-cerebral, other-organ malperfusion are common in patients with CCA dissection. While there is a high risk for stroke in patients with CCA occlusion, CCA flow impairment and occlusion were not predictive for in-hospital mortality. Surgery should not be denied to patients with CCA flow impairment or occlusion. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder

Author

Guihaire, Julien, primary, Itagaki, Ryo, additional, Stubbendorff, Mandy, additional, Hua, Xiaoqin, additional, Deuse, Tobias, additional, Ullrich, Sebastian, additional, Fadel, Elie, additional, Dorfmüller, Peter, additional, Robbins, Robert C., additional, Reichenspurner, Hermann, additional, Schumacher, Udo, additional, and Schrepfer, Sonja, additional

Published
2016
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35. miR-21 promotes fibrosis in an acute cardiac allograft transplantation model

Author

Gupta, Shashi Kumar, primary, Itagaki, Ryo, additional, Zheng, Xiang, additional, Batkai, Sandor, additional, Thum, Sabrina, additional, Ahmad, Fareed, additional, Van Aelst, Lucas N., additional, Sharma, Amit, additional, Piccoli, Maria-Teresa, additional, Weinberger, Florian, additional, Fiedler, Jan, additional, Heuser, Michael, additional, Heymans, Stephane, additional, Falk, Christine S., additional, Förster, Reinhold, additional, Schrepfer, Sonja, additional, and Thum, Thomas, additional

Published
2016
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37. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

Author

Deuse, Tobias, Wang, Dong, Stubbendorff, Mandy, Itagaki, Ryo, Grabosch, Antje, Greaves, Laura C., Alawi, Malik, Grünewald, Anne, Hu, Xiaomeng, Hua, Xiaoqin, Velden, Joachim, Reichenspurner, Hermann, Robbins, Robert C., Jaenisch, Rudolf, Weissman, Irving L., Schrepfer, Sonja, Deuse, Tobias, Wang, Dong, Stubbendorff, Mandy, Itagaki, Ryo, Grabosch, Antje, Greaves, Laura C., Alawi, Malik, Grünewald, Anne, Hu, Xiaomeng, Hua, Xiaoqin, Velden, Joachim, Reichenspurner, Hermann, Robbins, Robert C., Jaenisch, Rudolf, Weissman, Irving L., and Schrepfer, Sonja

Abstract

The generation of pluripotent stem cells by somatic cell nuclear transfer (SCNT) has recently been achieved in human cells and sparked new interest in this technology. The authors reporting this methodical breakthrough speculated that SCNT would allow the creation of patient-matched embryonic stem cells, even in patients with hereditary mitochondrial diseases. However, herein we show that mismatched mitochondria in nuclear-transfer-derived embryonic stem cells (NT-ESCs) possess alloantigenicity and are subject to immune rejection. In a murine transplantation setup, we demonstrate that allogeneic mitochondria in NT-ESCs, which are nucleus-identical to the recipient, may trigger an adaptive alloimmune response that impairs the survival of NT-ESC grafts. The immune response is adaptive, directed against mitochondrial content, and amenable for tolerance induction. Mitochondrial alloantigenicity should therefore be considered when developing therapeutic SCNT-based strategies.

Published
2015
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41. SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts

Author

Deuse, Tobias, primary, Wang, Dong, additional, Stubbendorff, Mandy, additional, Itagaki, Ryo, additional, Grabosch, Antje, additional, Greaves, Laura C., additional, Alawi, Malik, additional, Grünewald, Anne, additional, Hu, Xiaomeng, additional, Hua, Xiaoqin, additional, Velden, Joachim, additional, Reichenspurner, Hermann, additional, Robbins, Robert C., additional, Jaenisch, Rudolf, additional, Weissman, Irving L., additional, and Schrepfer, Sonja, additional

Published
2015
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43. Bicuspidalization of the Native Tricuspid Aortic Valve: A Porcine in Vivo Model of Bicuspid Aortopathy.

Author

Kimura N, Itagaki R, Nakamura M, Tofrizal A, Yatabe M, Yoshizaki T, Kokubo R, Hishikawa S, Kunita S, Adachi H, Misawa Y, Yashiro T, and Kawahito K

Abstract

Objective : To examine early histologic changes in the aorta exposed to bicuspid flow. Material and Methods : A porcine bicuspid aortopathy model was developed by suturing aortic cusps. Of nine pigs, eight underwent sham surgery (n=3) or bicuspidalization (n=5); one was used as an intact control. Wall shear stress (WSS) was assessed by computational fluid dynamics (CFD). Animals were exposed to normal or bicuspid flow for 48 h and were then euthanized for histologic examinations. Results : No animal died intraoperatively. One animal subjected to bicuspidalization died of respiratory failure during postoperative imaging studies. Echocardiography showed the aortic valve area decreased from 2.52±1.15 to 1.21±0.48 cm 2 after bicuspidalization, CFD revealed increased maximum WSS (10.0±5.2 vs. 54.0±25.7 Pa; P=0.036) and percentage area of increased WSS (>5 Pa) in the ascending aorta (30.3%±24.1% vs. 81.3%±13.4%; P=0.015) after bicuspidalization. Hematoxylin-eosin staining and transmission electron microscopy showed subintimal edema and detached or degenerated endothelial cells following both sham surgery and bicuspidalization, regardless of WSS distribution. Conclusion : A bicuspid aortic valve appears to increase aortic WSS. The endothelial damage observed might have been related to non-pulsatile flow (cardiopulmonary bypass). Chronic experiments are needed to clarify the relationship between hemodynamic stress and development of bicuspid aortopathy., Competing Interests: Disclosure StatementThe authors have no conflicts of interest to disclose., (© 2022 The Editorial Committee of Annals of Vascular Diseases.)

Published
2022
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44. [Two-staged hybrid surgery for an extended thoracic aortic aneurysm with Komerell's diverticulum].

Author

Itagaki R, Tanaka M, Ogino H, Ikegaya Y, Shimada N, Katayama I, and Itoh S

Subjects
Aged, 80 and over, Aorta, Thoracic surgery, Humans, Male, Vascular Surgical Procedures methods, Aortic Aneurysm, Thoracic surgery, Subclavian Artery abnormalities
Abstract

We have successfully performed 2 staged hybrid operation for an extended thoracic aortic aneurysm with Komerell diverticulum, which lessened surgical stress of the patient with avoidance of postoperative complications. An 82-year-old man who had been under observation for thoracic aortic aneurysm was admitted to the hospital with continuous chest discomfort. The patient initially underwent graft replacement for an ascending and arch aneurysm by using the elephant trunk technique. Thirty-five days later, he underwent endovascular repair for the residual descending thoracic aneurysm. The postoperative course was uneventful, and postoperative computed tomography (CT) revealed no stent migration and just a little type II endoleak. This 2 staged hybrid approach might be less invasive than the conventional approach, and be a potential therapeutic option for high risk patients with an extended thoracic aortic aneurysm.

Published
2012

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