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Your search keyword '"ItaNet (Italian Association for Neuroendocrine Tumours) Study Group"' showing total 3 results
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3 results on '"ItaNet (Italian Association for Neuroendocrine Tumours) Study Group"'

1. Duodenal Gastric Metaplasia and Duodenal Neuroendocrine Neoplasms: More Than a Simple Coincidence?

Author

Sara, Massironi, Roberta Elisa, Rossi, Anna Caterina, Milanetto, Valentina, Andreasi, Davide, Campana, Gennaro, Nappo, Stefano, Partelli, Camilla, Gallo, Miki, Scaravaglio, Alessandro, Zerbi, Francesco, Panzuto, Claudio, Pasquali, Massimo, Falconi, Pietro, Invernizzi, On Behalf Of ItaNet Italian Association For Neuroendocrine Tumours Study Group, Massironi S., Rossi R.E., Milanetto A.C., Andreasi V., Campana D., Nappo G., Partelli S., Gallo C., Scaravaglio M., Zerbi A., Panzuto F., Pasquali C., Falconi M., Invernizzi P., Massironi, Sara, Rossi, Roberta Elisa, Milanetto, Anna Caterina, Andreasi, Valentina, Campana, Davide, Nappo, Gennaro, Partelli, Stefano, Gallo, Camilla, Scaravaglio, Miki, Zerbi, Alessandro, Panzuto, Francesco, Pasquali, Claudio, Falconi, Massimo, Invernizzi, Pietro, and On Behalf Of ItaNet Italian Association For Neuroendocrine Tumours Study Group, Null

Subjects
duodenal neuroendocrine neoplasms, duodenal gastric metaplasia, risk factor, epidemiology, duodenal neuroendocrine neoplasm, General Medicine
Abstract

Background: Duodenal gastric metaplasia (DGM) is considered a precancerous lesion. No data are available regarding its possible role as a risk factor for duodenal neuroendocrine neoplasms (dNENs). Aims: To assess the prevalence of DGM in a cohort of dNENs. Methods: Subgroup analysis of a retrospective study including dNEN patients who underwent surgical resection between 2000 and 2019 and were observed at eight Italian tertiary referral centers. Results: 109 dNEN patients were evaluated. Signs of DGM associated with the presence of dNEN were reported in 14 patients (12.8%). Among these patients, nine (64.4%) had a dNEN of the superior part of the duodenum, one (7.1%) a periampullary lesion, three (21.4%) a dNEN located in the second portion of the duodenum, with a different localization distribution compared to patients without DGM (p = 0.0332). Ten were G1, three G2, and in one patient the Ki67 was not available. In the group with DGM, six patients (35.7%) were classified at stage I, five (28.6%) at stage II, three (21.4%) at stage III, and no one at stage IV. In the group without DGM, 20 patients (31%) were at stage I, 15 (15%) at stage II, 42 (44%) at stage III, and 19 (20%) at stage IV (p = 0.0236). At the end of the study, three patients died because of disease progression. Conclusions: our findings might suggest that DGM could represent a feature associated with the occurrence of dNEN, especially for forms of the superior part of the duodenum, which should be kept in mind in the endoscopic follow up of patients with DGM. Interestingly, dNEN inside DGM showed a more favorable staging, with no patients in stage IV. The actual relationship and the clinical relevance of this possible association require further clarification.

Published
2022

2. Second primary neoplasms in patients with lung and gastroenteropancreatic neuroendocrine neoplasms: Data from a retrospective multi-centric study

Author

Massironi, S., Campana, D., Pusceddu c, S., Albertelli, M., Faggiano e, A., Panzuto f, F., Smiroldo g, V., Andreasi h, V., Rossi i, R. E., Maggio b, I., Torchio c, M., Dotto, A., Modica j, R., Rinzivillo f, M., Carnaghi k, C., Partelli h, S., Fanetti l, I., Lamberti b, G., Corti c, F., Ferone, D., Colao j, A., Annibale f, B., M, Invernizzi a, P., Falconi h, M., and ItaNet (Italian Association for Neuroendocrine Tumours) Study Group

Published
2020

3. Duodenal Gastric Metaplasia and Duodenal Neuroendocrine Neoplasms: More Than a Simple Coincidence?

Author

Massironi S, Rossi RE, Milanetto AC, Andreasi V, Campana D, Nappo G, Partelli S, Gallo C, Scaravaglio M, Zerbi A, Panzuto F, Pasquali C, Falconi M, Invernizzi P, and On Behalf Of ItaNet Italian Association For Neuroendocrine Tumours Study Group

Abstract

Background: Duodenal gastric metaplasia (DGM) is considered a precancerous lesion. No data are available regarding its possible role as a risk factor for duodenal neuroendocrine neoplasms (dNENs)., Aims: To assess the prevalence of DGM in a cohort of dNENs., Methods: Subgroup analysis of a retrospective study including dNEN patients who underwent surgical resection between 2000 and 2019 and were observed at eight Italian tertiary referral centers., Results: 109 dNEN patients were evaluated. Signs of DGM associated with the presence of dNEN were reported in 14 patients (12.8%). Among these patients, nine (64.4%) had a dNEN of the superior part of the duodenum, one (7.1%) a periampullary lesion, three (21.4%) a dNEN located in the second portion of the duodenum, with a different localization distribution compared to patients without DGM ( p = 0.0332). Ten were G1, three G2, and in one patient the Ki67 was not available. In the group with DGM, six patients (35.7%) were classified at stage I, five (28.6%) at stage II, three (21.4%) at stage III, and no one at stage IV. In the group without DGM, 20 patients (31%) were at stage I, 15 (15%) at stage II, 42 (44%) at stage III, and 19 (20%) at stage IV ( p = 0.0236). At the end of the study, three patients died because of disease progression., Conclusions: our findings might suggest that DGM could represent a feature associated with the occurrence of dNEN, especially for forms of the superior part of the duodenum, which should be kept in mind in the endoscopic follow up of patients with DGM. Interestingly, dNEN inside DGM showed a more favorable staging, with no patients in stage IV. The actual relationship and the clinical relevance of this possible association require further clarification.

Published
2022
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