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205 results on '"Issat Tadeusz"'

2. The SPRi determination of cathepsin L and S in plasma and peritoneal fluid of women with endometriosis

Author

Załęcka, Julia, Zielińska, Zuzanna, Ołdak, Łukasz, Sakowicz, Agata, Mańka, Grzegorz, Kiecka, Mariusz, Spaczyński, Robert, Piekarski, Piotr, Banaszewska, Beata, Jakimiuk, Artur, Issat, Tadeusz, Młodawski, Jakub, Szubert, Maria, Sieroszewski, Piotr, Raba, Grzegorz, Szczupak, Kamil, Kluz, Tomasz, Kluza, Marek, Pierzyński, Piotr, Ciebiera, Michał, Wojtyła, Cezary, Lipa, Michał, Warzecha, Damian, Wielgoś, Mirosław, Cendrowski, Krzysztof, Gorodkiewicz, Ewa, and Laudański, Piotr

Published
2024
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3. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice

Author

Jozkowicz Alicja, Was Halina, Issat Tadeusz, Salwa Pawel, Szokalska Angelika, Bil Jacek, Winiarska Magdalena, Bugajski Marek, Nowis Dominika, Dulak Jozef, Stoklosa Tomasz, and Golab Jakub

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background HO-1 participates in the degradation of heme. Its products can exert unique cytoprotective effects. Numerous tumors express high levels of HO-1 indicating that this enzyme might be a potential therapeutic target. In this study we decided to evaluate potential cytostatic/cytotoxic effects of zinc protoporphyrin IX (Zn(II)PPIX), a selective HO-1 inhibitor and to evaluate its antitumor activity in combination with chemotherapeutics. Methods Cytostatic/cytotoxic effects of Zn(II)PPIX were evaluated with crystal violet staining and clonogenic assay. Western blotting was used for the evaluation of protein expression. Flow cytometry was used to evaluate the influence of Zn(II)PPIX on the induction of apoptosis and generation of reactive oxygen species. Knock-down of HO-1 expression was achieved with siRNA. Antitumor effects of Zn(II)PPIX alone or in combination with chemotherapeutics were measured in transplantation tumor models. Results Zn(II)PPIX induced significant accumulation of reactive oxygen species in tumor cells. This effect was partly reversed by administration of exogenous bilirubin. Moreover, Zn(II)PPIX exerted potent cytostatic/cytotoxic effects against human and murine tumor cell lines. Despite a significant time and dose-dependent decrease in cyclin D expression in Zn(II)PPIX-treated cells no accumulation of tumor cells in G1 phase of the cell cycle was observed. However, incubation of C-26 cells with Zn(II)PPIX increased the percentage of cells in sub-G1 phase of the cells cycle. Flow cytometry studies with propidium iodide and annexin V staining as well as detection of cleaved caspase 3 by Western blotting revealed that Zn(II)PPIX can induce apoptosis of tumor cells. B16F10 melanoma cells overexpressing HO-1 and transplanted into syngeneic mice were resistant to either Zn(II)PPIX or antitumor effects of cisplatin. Zn(II)PPIX was unable to potentiate antitumor effects of 5-fluorouracil, cisplatin or doxorubicin in three different tumor models, but significantly potentiated toxicity of 5-FU and cisplatin. Conclusion Inhibition of HO-1 exerts antitumor effects but should not be used to potentiate antitumor effects of cancer chemotherapeutics unless procedures of selective tumor targeting of HO-1 inhibitors are developed.

Published
2008
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5. Is the leptin/BMI ratio a reliable biomarker for endometriosis?

Author

Zyguła, Aleksandra, primary, Sankiewicz, Anna, additional, Sakowicz, Agata, additional, Dobrzyńska, Ewa, additional, Dakowicz, Agnieszka, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Spaczynski, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluza, Tomasz, additional, Kluza, Marek, additional, Pierzyński, Piotr, additional, Wojtyla, Cezary, additional, Lipa, Michal, additional, Warzecha, Damian, additional, Wielgos, Miroslaw, additional, Cendrowski, Krzysztof, additional, Gorodkiewicz, Ewa, additional, and Laudanski, Piotr, additional

Published
2024
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6. The application of platelet-rich plasma during laparotomy in patients with gynaecological malignancies improves wound healing and reduces postoperative pain feeling – a single-blind placebo controlled intervention study (preliminary report).

Author

Barwijuk, Michał, Pankiewicz, Katarzyna, Gałaś, Aleksander, Nowakowski, Filip, Sachadel, Katarzyna, Jakimiuk, Artur J., and Issat, Tadeusz

Subjects
PLATELET-rich plasma, ABDOMINAL surgery, GYNECOLOGY, WOUND healing, POSTOPERATIVE pain
Abstract

Introduction: This study was aimed to evaluate the impact of platelet-rich-plasma (PRP) application into the wound during laparotomy in gynaecological cancer patients on wound healing and postoperative pain. Material and methods: Forty-six patients undergoing surgical treatment due to gynaecological malignancies were included in this single-blind placebo-controlled intervention study: 23 women in the PRP group and 23 patients in the placebo group. Postoperative pain was assessed by using the visual analogue scale immediately after surgery, and 6 and 12 hours after the surgery. The use of analgesics after surgery was also recorded. The postoperative scar was assessed by patient and clinician using the patient and observer scar assessment scale (POSAS). Results: Wound dehiscence was diagnosed in 1 (4.3%) patient in the PRP group and 4 (17.4%) women in the control group (p = 0.346). After adjustment, the risk of wound dehiscence after PRP application was significantly lower in comparison to the control group (odds ratio – OR, 0.17; 95% CI: 0.03–0.92; p = 0.040). The risk of reporting more intense pain associated with PRP treatment 12 hours after surgery was significantly reduced (OR 0.25; 95% CI: 0.07–0.83; p = 0.023). Platelet-rich-plasma patients required fewer total morphine doses than the control group (8.22 ±3.3 vs. 10.96 ±5.05; p = 0.048). Significant differences between the groups in the scar quality assessment were also detected on the basis of POSAS scale on days 8, 30, and 90 after surgery. Conclusions: Platelet-rich-plasma application during abdominal closure in gynaecological cancer patients may improve wound healing, as well as reduce pain and the use of analgesics in the early postoperative period. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Bartter[StQuote]s syndrome as a forgotten cause of polyhydramnios

Author

Malarska, Maria, primary, Moczulska, Hanna, additional, Pachniak, Paulina, additional, Gadzalska, Karolina, additional, Jakiel, Paulina, additional, Kowalczyk- Buss, Joanna, additional, Krajewska, Karolina, additional, Kozłowski, Szymon, additional, Borowiec, Maciej, additional, Issat, Tadeusz, additional, and Zmysłowska, Agnieszka, additional

Published
2024
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11. Vitamin d-binding protein (VDBP) and lactoferrin (LF) in plasma and peritoneal fluid (PF) in the diagnosis of endometriosis

Author

Wróbel, Monika, primary, Lisowska-Myjak, Barbara, additional, Skarzyńska, Ewa, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Lipa, Michał, additional, Warzecha, Damian, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Wielgoś, Mirosław, additional, and Laudański, Piotr, additional

Published
2024
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12. Plasma and Peritoneal Fluid Annexin A2 Levels in Patients with Endometriosis

Author

Zygarowicz, Michal, primary, Kacperczyk-Bartnik, Joanna, additional, Sierdzinski, Janusz, additional, Wojtyla, Cezary, additional, Pierzynski, Piotr, additional, Manka, Grzegorz, additional, Kiecka, Mariusz, additional, Spaczynski, Robert Z, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Mlodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Lipa, Michal, additional, Warzecha, Damian, additional, Wielgos, Miroslaw, additional, Koc-Zorawska, Ewa, additional, Zorawski, Marcin, additional, and Laudanski, Piotr, additional

Published
2023
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13. Intrahepatic Cholestasis of Pregnancy during COVID-19 Pandemic.

Author

Malarkiewicz, Paulina, Nowacka, Urszula, Januszaniec, Aleksandra, Mankiewicz, Alicja, Kozłowski, Szymon, and Issat, Tadeusz

Subjects
COVID-19 pandemic, CHOLESTASIS, PREGNANCY, OBSTETRICS, MULTIPLE regression analysis
Abstract

Background and Objectives: Intrahepatic cholestasis of pregnancy (ICP) stands as one of the most prevalent concerns in maternal–fetal medicine, presenting a significant risk to fetal health and often associated with liver dysfunction. Concurrently, the coronavirus-19 (COVID-19) infection can lead to hepatic cell injury through both direct and indirect pathways. Hypothetically, these two conditions may coincide, influencing each other. This study aimed to comparatively assess the incidence and severity of ICP before and during the COVID-19 pandemic. Methods: A retrospective cohort study was conducted, comparing the incidence and severity of ICP between January 2018 and February 2020 (pre-COVID-19 period) and March 2020 to March 2022 (COVID-19 period) across two hospitals, encompassing 7799 deliveries. The diagnosis of ICP was established using the ICD-10 code and defined as total bile acids (BA) levels ≥ 10 μmol/L. Statistical analysis included descriptive statistics, Chi-square and Mann–Whitney U tests, as well as multiple or logistic regression analysis. Results: A total of 226 cases of ICP were identified. The incidence of mild cholestasis (BA < 40 μmol/L) was lower during the pandemic compared to before (3% before versus 2%, p < 0.05), while the incidence of moderate and severe ICP remained unchanged (0.6% before vs. 0.4%, p = 0.2). Overall, the total incidence of ICP was lower during the pandemic (3.6% before versus 2.4%, p = 0.01). No significant differences were observed in severity (as defined by BA and liver function test levels), rates of caesarean section, or neonatal birth weights. Conclusions: During the COVID-19 pandemic, the total incidence of ICP appeared to be lower. However, this reduction was primarily observed in cases of mild ICP, potentially indicating challenges in detection or reduced access to medical services during this period. The incidence of moderate and severe ICP remained unchanged, suggesting that these forms of the condition were unaffected by the pandemic's circumstances. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis

Author

Wróbel, Monika, primary, Zuzanna, Zielińska, additional, Ołdak, Łukasz, additional, Kalicka, Aleksandra, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Spaczyński, Robert Z., additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Pierzyński, Piotr, additional, Wojtyła, Cezary, additional, Lipa, Michał, additional, Warzecha, Damian, additional, Wielgoś, Mirosław, additional, Sawicki, Włodzimierz, additional, Gorodkiewicz, Ewa, additional, and Laudański, Piotr, additional

Published
2023
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17. Rhabdomyosarcoma of the genitourinary system in girls -- the role of magnetic resonance imaging in diagnosis, treatment monitoring, and follow-up.

Author

Sobieraj, Paulina, Malas, Zofia, Issat, Tadeusz, Raciborska, Anna, and Bekiesinska-Figatowska, Monika

Subjects
RHABDOMYOSARCOMA, GENITOURINARY organs, MAGNETIC resonance imaging, SYMPTOMS, CANCER chemotherapy
Abstract

Objectives: Rhabdomyosarcoma of the genitourinary system in girls is a rare neoplasm, especially in non-dedicated centers. Our work aimed to sum up and present genitourinary rhabdomyosarcomas in girls from the radiological point of view. Material and methods: We retrospectively reviewed all girls with genitourinary RMS who underwent treatment at the Institute of Mother and Child in Warsaw between 2009 and 2022. We evaluated the demographic, clinical, and pathological patient data and imaging studies. Results: During the study period, ten patients presented with genitourinary RMS and underwent magnetic resonance imaging (MRI). The median age at the time of diagnosis was 2.8 years, six patients were younger than three years, and four patients were older than ten years. The most common clinical symptoms were tumor fragments protruding from the vagina/falling out of the vagina and vaginal bleeding or discharge, and the most common original location was the vagina. One hundred percent of patients had the embryonal subtype of RMS, and 100% of cases where molecular tests for PAX3/FOXO1 fusion gen status were performed had negative status. At presentation, the median tumor volume was 114 cm3. Eight patients (80%) were classified as clinical group III according to the IRS Group, and most patients (70%) were in a standard-risk group. All patients received multimodal treatment, including surgery and chemotherapy; 60% received radiotherapy. Neoadjuvant chemotherapy was the primary treatment for all our patients. In six patients (60%) with a measurable tumor mass after a biopsy, a gradual tumor volume reduction was observed after induction chemotherapy (approximately ten weeks of treatment) -- all of which had a partial response (PR). All our patients (100%) responded completely to treatment. Conclusions: MRI was performed at every stage of diagnosis and treatment as well as during follow-up. It allowed for staging, monitoring of chemotherapy, and guided surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis

Author

Lisowska-Myjak, Barbara, primary, Skarżyńska, Ewa, additional, Wróbel, Monika, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Lipa, Michał, additional, Warzecha, Damian, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Wielgoś, Mirosław, additional, and Laudański, Piotr, additional

Published
2023
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19. Data from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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20. Supplementary Figure 2 from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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21. Supplementary Figure 6 from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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22. Supplementary Table 1, Methods and Materials, Figure Legends 1-6 from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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23. Supplementary Figure 5 from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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24. Supplementary Figure 1 from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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25. Supplementary Figure 3 from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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26. Supplementary Figure 4 from Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Author

Szokalska, Angelika, primary, Makowski, Marcin, primary, Nowis, Dominika, primary, Wilczyński, Grzegorz M., primary, Kujawa, Marek, primary, Wójcik, Cezary, primary, Młynarczuk-Biały, Izabela, primary, Salwa, Pawel, primary, Bil, Jacek, primary, Janowska, Sylwia, primary, Agostinis, Patrizia, primary, Verfaillie, Tom, primary, Bugajski, Marek, primary, Gietka, Jan, primary, Issat, Tadeusz, primary, Głodkowska, Eliza, primary, Mrówka, Piotr, primary, Stoklosa, Tomasz, primary, Hamblin, Michael R., primary, Mróz, Paweł, primary, Jakóbisiak, Marek, primary, and Golab, Jakub, primary

Published
2023
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28. Plasma and Peritoneal Fluid Annexin A2 Levels in Patients with Endometriosis

Author

Zygarowicz,Michal, Kacperczyk-Bartnik,Joanna, Sierdzinski,Janusz, Wojtyla,Cezary, Pierzynski,Piotr, Manka,Grzegorz, Kiecka,Mariusz, Spaczynski,Robert Z, Piekarski,Piotr, Banaszewska,Beata, Jakimiuk,Artur, Issat,Tadeusz, Rokita,Wojciech, Mlodawski,Jakub, Szubert,Maria, Sieroszewski,Piotr, Raba,Grzegorz, Szczupak,Kamil, Kluz,Tomasz, Kluza,Marek, Lipa,Michal, Warzecha,Damian, Wielgos,Miroslaw, Koc-Zorawska,Ewa, Zorawski,Marcin, Laudanski,Piotr, Zygarowicz,Michal, Kacperczyk-Bartnik,Joanna, Sierdzinski,Janusz, Wojtyla,Cezary, Pierzynski,Piotr, Manka,Grzegorz, Kiecka,Mariusz, Spaczynski,Robert Z, Piekarski,Piotr, Banaszewska,Beata, Jakimiuk,Artur, Issat,Tadeusz, Rokita,Wojciech, Mlodawski,Jakub, Szubert,Maria, Sieroszewski,Piotr, Raba,Grzegorz, Szczupak,Kamil, Kluz,Tomasz, Kluza,Marek, Lipa,Michal, Warzecha,Damian, Wielgos,Miroslaw, Koc-Zorawska,Ewa, Zorawski,Marcin, and Laudanski,Piotr

Abstract

Michal Zygarowicz,1,&ast; Joanna Kacperczyk-Bartnik,2,3,&ast; Janusz Sierdzinski,4 Cezary Wojtyla,5,6 Piotr Pierzynski,5,6 Grzegorz Manka,7 Mariusz Kiecka,7 Robert Z Spaczynski,8 Piotr Piekarski,9 Beata Banaszewska,10 Artur Jakimiuk,11,12 Tadeusz Issat,13 Wojciech Rokita14,15 ,†Jakub Mlodawski,14,15 Maria Szubert,3,16,17 Piotr Sieroszewski,16,18 Grzegorz Raba,19,20 Kamil Szczupak,19,20 Tomasz Kluz,21 Marek Kluza,21 Michal Lipa,3,22 Damian Warzecha,5,22 Miroslaw Wielgos,23,24 Ewa Koc-Zorawska,25,26 Marcin Zorawski,26,27 Piotr Laudanski5,6,28 1Students’ Scientific Group Affiliated to the Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Warsaw, Poland; 2II Department of Obstetrics and Gynaecology, Medical University of Warsaw, Warsaw, Poland; 3Club 35. Polish Society of Gynecologists and Obstetricians, Wroc&lstrok;aw, Poland; 4Department of Medical Informatics and Telemedicine, Medical University of Warsaw, Warsaw, Poland; 5OVIklinika Infertility Center, Warsaw, Poland; 6Women’s Health Research Institute, Calisia University, Kalisz, Poland; 7Angelius Provita Hospital, Katowice, Poland; 8Center for Gynecology, Obstetrics and Infertility Treatment Pastelova, Poznan, Poland; 9Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland; 10Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland; 11Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland; 12Center of Reproductive Health, Institute of Mother and Child in Warsaw, Warsaw, Poland; 13Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Warsaw, Poland; 14Collegium Medicum Jan Kochanowski University in Kielce, Kielce, Poland; 15Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, Kielce

Published
2023

29. Autoantibody screening of plasma and peritoneal fluid of patients with endometriosis

Author

Laudański, Piotr, primary, Rogalska, Gabriela, additional, Warzecha, Damian, additional, Lipa, Michał, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Neuman, Toomas, additional, Adler, Priit, additional, Peterson, Hedi, additional, Salumets, Andres, additional, and Wielgos, Miroslaw, additional

Published
2023
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30. The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

Author

Skarżyńska, Ewa, primary, Wróbel, Monika, additional, Zborowska, Hanna, additional, Kołek, Mateusz Franciszek, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Lipa, Michał, additional, Warzecha, Damian, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Wielgoś, Mirosław, additional, Lisowska-Myjak, Barbara, additional, and Laudański, Piotr, additional

Published
2023
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32. Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis

Author

Warzecha, Damian, primary, Załęcka, Julia, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Lipa, Michał, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Wielgoś, Mirosław, additional, Ołdak, Łukasz, additional, Leśniewska, Anna, additional, Gorodkiewicz, Ewa, additional, and Laudański, Piotr, additional

Published
2022
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34. Plasma and Peritoneal Fluid ZEB Levels in Patients with Endometriosis and Infertility

Author

Bartnik, Paweł, primary, Kacperczyk-Bartnik, Joanna, additional, Goławski, Ksawery, additional, Sierdziński, Janusz, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Lipa, Michał, additional, Warzecha, Damian, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur J., additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Czajkowski, Krzysztof, additional, Wielgoś, Mirosław, additional, Koc-Żórawska, Ewa, additional, Żórawski, Marcin, additional, and Laudański, Piotr, additional

Published
2022
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35. Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis

Author

Kacperczyk-Bartnik, Joanna, primary, Bartnik, Paweł, additional, Goławski, Ksawery, additional, Sierdziński, Janusz, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Lipa, Michał, additional, Warzecha, Damian, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Czajkowski, Krzysztof, additional, Wielgoś, Mirosław, additional, Koc-Żórawska, Ewa, additional, Żórawski, Marcin, additional, and Laudański, Piotr, additional

Published
2022
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36. The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among Patients with Endometriosis and Endometriosis-Related Infertility

Author

Goławski, Ksawery, primary, Soczewica, Robert, additional, Kacperczyk-Bartnik, Joanna, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Lipa, Michał, additional, Warzecha, Damian, additional, Spaczyński, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluz, Tomasz, additional, Kluza, Marek, additional, Wielgoś, Mirosław, additional, Koc-Żórawska, Ewa, additional, Żórawski, Marcin, additional, and Laudański, Piotr, additional

Published
2022
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40. Comparative Genomic Hybridization to Microarrays in Fetuses with High-Risk Prenatal Indications: Polish Experience with 7400 Pregnancies

Author

Kowalczyk, Katarzyna, primary, Bartnik-Głaska, Magdalena, additional, Smyk, Marta, additional, Plaskota, Izabela, additional, Bernaciak, Joanna, additional, Kędzior, Marta, additional, Wiśniowiecka-Kowalnik, Barbara, additional, Deperas, Marta, additional, Domaradzka, Justyna, additional, Łuszczek, Alicja, additional, Dutkiewicz, Daria, additional, Kozar, Agata, additional, Grad, Dominika, additional, Niemiec, Magdalena, additional, Ziemkiewicz, Kamila, additional, Magdziak, Róża, additional, Braun-Walicka, Natalia, additional, Barczyk, Artur, additional, Geremek, Maciej, additional, Castañeda, Jennifer, additional, Kutkowska-Kaźmierczak, Anna, additional, Własienko, Paweł, additional, Jakubów-Durska, Krystyna, additional, Dębska, Marzena, additional, Kucińska-Chahwan, Anna, additional, Kozłowski, Szymon, additional, Mikulska, Boyana, additional, Issat, Tadeusz, additional, Roszkowski, Tomasz, additional, Nawara-Baran, Agnieszka, additional, Runge, Agata, additional, Jakubiuk-Tomaszuk, Anna, additional, Kruczek, Anna, additional, Kostyk, Ewa, additional, Pietras, Grzegorz, additional, Limon, Janusz, additional, Zwoliński, Jerzy, additional, Ochman, Karolina, additional, Szajner, Tomasz, additional, Węgrzyn, Piotr, additional, Wielgoś, Mirosław, additional, Sąsiadek, Maria, additional, Obersztyn, Ewa, additional, and Nowakowska, Beata Anna, additional

Published
2022
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43. Prenatal Diagnosis by Array Comparative Genomic Hybridization in Fetuses with Cardiac Abnormalities

Author

Kowalczyk, Katarzyna, primary, Bartnik-Głaska, Magdalena, additional, Smyk, Marta, additional, Plaskota, Izabela, additional, Bernaciak, Joanna, additional, Kędzior, Marta, additional, Wiśniowiecka-Kowalnik, Barbara, additional, Jakubów-Durska, Krystyna, additional, Braun-Walicka, Natalia, additional, Barczyk, Artur, additional, Geremek, Maciej, additional, Castañeda, Jennifer, additional, Kutkowska-Kaźmierczak, Anna, additional, Własienko, Paweł, additional, Dębska, Marzena, additional, Kucińska-Chahwan, Anna, additional, Roszkowski, Tomasz, additional, Kozłowski, Szymon, additional, Mikulska, Boyana, additional, Issat, Tadeusz, additional, Obersztyn, Ewa, additional, and Nowakowska, Beata Anna, additional

Published
2021
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49. Statins impair antitumor effects of rituximab by inducing conformational changes of CD20

Author

Winiarska, Magdalena, Bil, Jacek, Wilczek, Ewa, Wilczynski, Grzegorz M., Lekka, Malgorzata, Engelberts, Patrick J., Mackus, Wendy J.M., Gorska, Elzbieta, Bojarski, Lukasz, Stoklosa, Tomasz, Nowis, Dominika, Kurzaj, Zuzanna, Makowski, Marcin, Glodkowska, Eliza, Issat, Tadeusz, Mrowka, Piotr, Lasek, Witold, Dabrowska-Iwanicka, Anna, Basak, Grzegorz W., Wasik, Maria, Warzocha, Krzysztof, Sinski, Maciej, Gaciong, Zbigniew, Jakobisiak, Marek, Parren, Paul W.H.I., and Golab, Jakub

Subjects
Biological sciences
Abstract

Background Rituximab is used in the treatment of [CD20.sup.+] B cell lymphomas and other B cell lymphoproliferative disorders. Its clinical efficacy might be further improved by combinations with other drugs such as statins that inhibit cholesterol synthesis and show promising antilymphoma effects. The objective of this study was to evaluate the influence of statins on rituximab-induced killing of B cell lymphomas. Methods and Findings Complement-dependent cytotoxicity (CDC) was assessed by MTT and Alamar blue assays as well as trypan blue staining, and antibody-dependent cellular cytotoxicity (ADCC) was assessed by a [sup.51]Cr release assay. Statins were found to significantly decrease rituximab-mediated CDC and ADCC of B cell lymphoma cells. Incubation of B cell lymphoma cells with statins decreased CD20 immunostaining in flow cytometry studies but did not affect total cellular levels of CD20 as measured with RT-PCR and Western blotting. Similar effects are exerted by other cholesteroldepleting agents (methyl-β-cyclodextrin and berberine), but not filipin III, indicating that the presence of plasma membrane cholesterol and not lipid rafts is required for rituximabmediated CDC. Immunofluorescence microscopy using double staining with monoclonal antibodies (mAbs) directed against a conformational epitope and a linear cytoplasmic epitope revealed that CD20 is present in the plasma membrane in comparable amounts in control and statin-treated cells. Atomic force microscopy and limited proteolysis indicated that statins, through cholesterol depletion, induce conformational changes in CD20 that result in impaired binding of anti-CD20 mAb. An in vivo reduction of cholesterol induced by short-term treatment of five patients with hypercholesterolemia with atorvastatin resulted in reduced anti-CD20 binding to freshly isolated B cells. Conclusions Statins were shown to interfere with both detection of CD20 and antilymphoma activity of rituximab. These studies have significant clinical implications, as impaired binding of mAbs to conformational epitopes of CD20 elicited by statins could delay diagnosis, postpone effective treatment, or impair anti-lymphoma activity of rituximab., Introduction Rituximab, a chimeric IgG1 monoclonal antibody (mAb) that binds the CD20 antigen, is approved for first-line treatment of follicular and diffuse large B cell lymphoma in combination with chemotherapy, [...]

Published
2008

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