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354 results on '"Issaeva, Natalia"'

2. APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma

Author

Cannataro, Vincent L, Gaffney, Stephen G, Sasaki, Tomoaki, Issaeva, Natalia, Grewal, Nicholas KS, Grandis, Jennifer R, Yarbrough, Wendell G, Burtness, Barbara, Anderson, Karen S, and Townsend, Jeffrey P

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Dental/Oral and Craniofacial Disease, Genetics, Cancer, Aetiology, 2.1 Biological and endogenous factors, Carcinogenesis, Class I Phosphatidylinositol 3-Kinases, Cytidine Deaminase, Exome, Head and Neck Neoplasms, Humans, Minor Histocompatibility Antigens, Mutagenesis, Mutation, Phenotype, Phosphatidylinositol 3-Kinases, Squamous Cell Carcinoma of Head and Neck, Clinical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Recent studies have revealed the mutational signatures underlying the somatic evolution of cancer, and the prevalences of associated somatic genetic variants. Here we estimate the intensity of positive selection that drives mutations to high frequency in tumors, yielding higher prevalences than expected on the basis of mutation and neutral drift alone. We apply this approach to a sample of 525 head and neck squamous cell carcinoma exomes, producing a rank-ordered list of gene variants by selection intensity. Our results illustrate the complementarity of calculating the intensity of selection on mutations along with tallying the prevalence of individual substitutions in cancer: while many of the most prevalently-altered genes were heavily selected, their relative importance to the cancer phenotype differs from their prevalence and from their P value, with some infrequent variants exhibiting evidence of strong positive selection. Furthermore, we extend our analysis of effect size by quantifying the degree to which mutational processes (such as APOBEC mutagenesis) contributes mutations that are highly selected, driving head and neck squamous cell carcinoma. We calculate the substitutions caused by APOBEC mutagenesis that make the greatest contribution to cancer phenotype among patients. Lastly, we demonstrate via in vitro biochemical experiments that the APOBEC3B protein can deaminate the cytosine bases at two sites whose mutant states are subject to high net realized selection intensities-PIK3CA E545K and E542K. By quantifying the effects of mutations, we deepen the molecular understanding of carcinogenesis in head and neck squamous cell carcinoma.

Published
2019

6. Characterization of HPV and host genome interactions in primary head and neck cancers

Author

Parfenov, Michael, Pedamallu, Chandra Sekhar, Gehlenborg, Nils, Freeman, Samuel S, Danilova, Ludmila, Bristow, Christopher A, Lee, Semin, Hadjipanayis, Angela G, Ivanova, Elena V, Wilkerson, Matthew D, Protopopov, Alexei, Yang, Lixing, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Ren, Xiaojia, Zhang, Jianhua, Pantazi, Angeliki, Santoso, Netty, Xu, Andrew W, Mahadeshwar, Harshad, Wheeler, David A, Haddad, Robert I, Jung, Joonil, Ojesina, Akinyemi I, Issaeva, Natalia, Yarbrough, Wendell G, Hayes, D Neil, Grandis, Jennifer R, El-Naggar, Adel K, Meyerson, Matthew, Park, Peter J, Chin, Lynda, Seidman, JG, Hammerman, Peter S, Kucherlapati, Raju, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Bowlby, Reanne, Butterfield, Yaron SN, Carlsen, Rebecca, Cheng, Dean, Chu, Andy, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A, Jones, Steven JM, Lee, Darlene, Li, Haiyan I, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Andrew J, Robertson, A Gordon, Schein, Jacqueline E, Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Wong, Tina, Mahadeshwar, Harshad S, Haseley, Psalm, Zeng, Dong, Bristow, Christopher, Hadjipanayis, Angela, Seidman, Jonathan, Akbani, Rehan, Casasent, Tod, Liu, Wenbin, Lu, Yiling, Mills, Gordon, Motter, Thomas, Weinstein, John, Diao, Lixia, Wang, Jing, Fan, You Hong, Liu, Jinze, Wang, Kai, Auman, J Todd, Balu, Saianand, Bodenheimer, Tom, Buda, Elizabeth, Hoadley, Katherine A, and Hoyle, Alan P

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Bioinformatics and Computational Biology, Genetics, Oncology and Carcinogenesis, Rare Diseases, Human Genome, Sexually Transmitted Infections, Cervical Cancer, Infectious Diseases, Dental/Oral and Craniofacial Disease, HIV/AIDS, Cancer, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Infection, Base Sequence, DNA Methylation, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Genome, Human, Head and Neck Neoplasms, Host-Pathogen Interactions, Humans, Molecular Sequence Data, Papillomaviridae, Virus Integration, cancer, head and neck, papilloma virus, genome rearrangement, integration sites, Cancer Genome Atlas Network
Abstract

Previous studies have established that a subset of head and neck tumors contains human papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display distinct biological and clinical features. HPV is known to drive cancer by the actions of the E6 and E7 oncoproteins, but the molecular architecture of HPV infection and its interaction with the host genome in head and neck cancers have not been comprehensively described. We profiled a cohort of 279 head and neck cancers with next generation RNA and DNA sequencing and show that 35 (12.5%) tumors displayed evidence of high-risk HPV types 16, 33, or 35. Twenty-five cases had integration of the viral genome into one or more locations in the human genome with statistical enrichment for genic regions. Integrations had a marked impact on the human genome and were associated with alterations in DNA copy number, mRNA transcript abundance and splicing, and both inter- and intrachromosomal rearrangements. Many of these events involved genes with documented roles in cancer. Cancers with integrated vs. nonintegrated HPV displayed different patterns of DNA methylation and both human and viral gene expressions. Together, these data provide insight into the mechanisms by which HPV interacts with the human genome beyond expression of viral oncoproteins and suggest that specific integration events are an integral component of viral oncogenesis.

Published
2014

7. Abstract PO-092: Molecular characterization of the salivary adenoid cystic carcinoma tumor immune landscape by anatomic subsite

Author

Tasoulas, Jason, primary, Schrank, Travis, additional, Johnson, Steven, additional, Divaris, Kimon, additional, Theocharis, Stamatios, additional, Hackman, Trevor, additional, Sheth, Siddharth, additional, Kirtane, Kedar, additional, Hernandez-Prera, Juan, additional, Chung, Christine, additional, Yarbrough, Wendell Gray, additional, Issaeva, Natalia, additional, and Amelio, Antonio, additional

Published
2023
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9. Quantifying the system balancing cost when wind energy is incorporated into electricity generation system

Author

Issaeva, Natalia

Subjects
333, wind energy, electricity networks, modelling
Abstract

Incorporation of wind energy into the electricity generation system requires a detailed analysis of wind speed in order to minimize system balancing cost and avoid a significant mismatch between supply and demand. Power generation and consumption in the electricity networks have to be balanced every minute, therefore it is necessary to study wind speed on a one-minute time scale. In this thesis, we examine the statistical characteristics of one-minute average values of wind speed. One-minute wind speed is available from a single site in Great Britain while there are records of ten-minute wind speed available. We apply a modified Gibbs sampling algorithm to generate one-minute wind speed required for optimization modelling from the available ten-minute wind speed. System balancing costs are estimated through optimization modelling of the short-term electricity generation with wind energy contributing to the total supply. Two main drivers of additional system cost caused by wind energy are variability and unpredictability of one-minute wind speed. Further, a linear mathematical optimization model for a problem of short-term electricity generation is presented to calculate an additional balancing cost that appears as a result of wind energy variability. It is then shown that this additional balancing cost can be estimated using the statistical characteristics of wind energy present in the system. The unpredictable characteristic of wind speed is analysed with the techniques of stochastic programming. Uncertainty of the expected wind speed is represented through scenario trees and stochastic linear optimization models are used to calculate the extra cost due to uncertainty. Alternative optimization models are compared by calculating the additional balancing cost and the extent of imbalance between power generation and consumption in the system.

Published
2009

10. Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors

Author

Schrank, Travis P., primary, Kothari, Aditi, additional, Weir, William H., additional, Stepp, Wesley H., additional, Rehmani, Hina, additional, Liu, Xinyi, additional, Wang, Xiaowei, additional, Sewell, Andrew, additional, Li, Xue, additional, Tasoulas, Jason, additional, Kim, Sulgi, additional, Yarbrough, Gray, additional, Xie, Yue, additional, Flamand, Yael, additional, Marur, Shanthi, additional, Hayward, Michele C., additional, Wu, Di, additional, Burtness, Barbara, additional, Anderson, Karen S., additional, Baldwin, Albert S., additional, Yarbrough, Wendell G., additional, and Issaeva, Natalia, additional

Published
2023
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15. Supplementary Figure from Comprehensive Viral Genotyping Reveals Prognostic Viral Phylogenetic Groups in HPV16-Associated Squamous Cell Carcinoma of the Oropharynx

Author

Schrank, Travis P., primary, Landess, Lee, primary, Stepp, Wesley H., primary, Rehmani, Hina, primary, Weir, William H., primary, Lenze, Nicholas, primary, Lal, Asim, primary, Wu, Di, primary, Kothari, Aditi, primary, Hackman, Trevor G., primary, Sheth, Siddharth, primary, Patel, Shetal, primary, Jefferys, Stuart R., primary, Issaeva, Natalia, primary, and Yarbrough, Wendell G., primary

Published
2023
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16. Supplementary Table from Comprehensive Viral Genotyping Reveals Prognostic Viral Phylogenetic Groups in HPV16-Associated Squamous Cell Carcinoma of the Oropharynx

Author

Schrank, Travis P., primary, Landess, Lee, primary, Stepp, Wesley H., primary, Rehmani, Hina, primary, Weir, William H., primary, Lenze, Nicholas, primary, Lal, Asim, primary, Wu, Di, primary, Kothari, Aditi, primary, Hackman, Trevor G., primary, Sheth, Siddharth, primary, Patel, Shetal, primary, Jefferys, Stuart R., primary, Issaeva, Natalia, primary, and Yarbrough, Wendell G., primary

Published
2023
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17. Data from Comprehensive Viral Genotyping Reveals Prognostic Viral Phylogenetic Groups in HPV16-Associated Squamous Cell Carcinoma of the Oropharynx

Author

Schrank, Travis P., primary, Landess, Lee, primary, Stepp, Wesley H., primary, Rehmani, Hina, primary, Weir, William H., primary, Lenze, Nicholas, primary, Lal, Asim, primary, Wu, Di, primary, Kothari, Aditi, primary, Hackman, Trevor G., primary, Sheth, Siddharth, primary, Patel, Shetal, primary, Jefferys, Stuart R., primary, Issaeva, Natalia, primary, and Yarbrough, Wendell G., primary

Published
2023
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18. Supplementary Information from Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers

Author

Zhang, Jialing, primary, Chen, Tony, primary, Yang, Xinping, primary, Cheng, Hui, primary, Späth, Stephan S., primary, Clavijo, Paul E., primary, Chen, Jianhong, primary, Silvin, Christopher, primary, Issaeva, Natalia, primary, Su, Xiulan, primary, Yarbrough, Wendell G., primary, Annunziata, Christina M., primary, Chen, Zhong, primary, and Van Waes, Carter, primary

Published
2023
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19. Supplemental Table 1 from Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers

Author

Zhang, Jialing, primary, Chen, Tony, primary, Yang, Xinping, primary, Cheng, Hui, primary, Späth, Stephan S., primary, Clavijo, Paul E., primary, Chen, Jianhong, primary, Silvin, Christopher, primary, Issaeva, Natalia, primary, Su, Xiulan, primary, Yarbrough, Wendell G., primary, Annunziata, Christina M., primary, Chen, Zhong, primary, and Van Waes, Carter, primary

Published
2023
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21. Supplementary Figure S5 from Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck

Author

Lee, Jong Woo, primary, Parameswaran, Janaki, primary, Sandoval-Schaefer, Teresa, primary, Eoh, Kyung Jin, primary, Yang, Dong-hua, primary, Zhu, Fang, primary, Mehra, Ranee, primary, Sharma, Roshan, primary, Gaffney, Stephen G., primary, Perry, Elizabeth B., primary, Townsend, Jeffrey P., primary, Serebriiskii, Ilya G., primary, Golemis, Erica A., primary, Issaeva, Natalia, primary, Yarbrough, Wendell G., primary, Koo, Ja Seok, primary, and Burtness, Barbara, primary

Published
2023
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22. Supplementary Figure Legends from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Author

Xiao, Lin, primary, Somers, Klaartje, primary, Murray, Jayne, primary, Pandher, Ruby, primary, Karsa, Mawar, primary, Ronca, Emma, primary, Bongers, Angelika, primary, Terry, Rachael, primary, Ehteda, Anahid, primary, Gamble, Laura D., primary, Issaeva, Natalia, primary, Leonova, Katerina I., primary, O'Connor, Aisling, primary, Mayoh, Chelsea, primary, Venkat, Pooja, primary, Quek, Hazel, primary, Brand, Jennifer, primary, Kusuma, Frances K., primary, Pettitt, Jessica A., primary, Mosmann, Erin, primary, Kearns, Adam, primary, Eden, Georgina, primary, Alfred, Stephanie, primary, Allan, Sophie, primary, Zhai, Lei, primary, Kamili, Alvin, primary, Gifford, Andrew J., primary, Carter, Daniel R., primary, Henderson, Michelle J., primary, Fletcher, Jamie I., primary, Marshall, Glenn, primary, Johnstone, Ricky W., primary, Cesare, Anthony J., primary, Ziegler, David S., primary, Gudkov, Andrei V., primary, Gurova, Katerina V., primary, Norris, Murray D., primary, and Haber, Michelle, primary

Published
2023
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24. Data from Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers

Author

Zhang, Jialing, primary, Chen, Tony, primary, Yang, Xinping, primary, Cheng, Hui, primary, Späth, Stephan S., primary, Clavijo, Paul E., primary, Chen, Jianhong, primary, Silvin, Christopher, primary, Issaeva, Natalia, primary, Su, Xiulan, primary, Yarbrough, Wendell G., primary, Annunziata, Christina M., primary, Chen, Zhong, primary, and Van Waes, Carter, primary

Published
2023
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25. Supplementary Video S1 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Author

Xiao, Lin, primary, Somers, Klaartje, primary, Murray, Jayne, primary, Pandher, Ruby, primary, Karsa, Mawar, primary, Ronca, Emma, primary, Bongers, Angelika, primary, Terry, Rachael, primary, Ehteda, Anahid, primary, Gamble, Laura D., primary, Issaeva, Natalia, primary, Leonova, Katerina I., primary, O'Connor, Aisling, primary, Mayoh, Chelsea, primary, Venkat, Pooja, primary, Quek, Hazel, primary, Brand, Jennifer, primary, Kusuma, Frances K., primary, Pettitt, Jessica A., primary, Mosmann, Erin, primary, Kearns, Adam, primary, Eden, Georgina, primary, Alfred, Stephanie, primary, Allan, Sophie, primary, Zhai, Lei, primary, Kamili, Alvin, primary, Gifford, Andrew J., primary, Carter, Daniel R., primary, Henderson, Michelle J., primary, Fletcher, Jamie I., primary, Marshall, Glenn, primary, Johnstone, Ricky W., primary, Cesare, Anthony J., primary, Ziegler, David S., primary, Gudkov, Andrei V., primary, Gurova, Katerina V., primary, Norris, Murray D., primary, and Haber, Michelle, primary

Published
2023
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26. Supplementary Figures from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Author

Xiao, Lin, primary, Somers, Klaartje, primary, Murray, Jayne, primary, Pandher, Ruby, primary, Karsa, Mawar, primary, Ronca, Emma, primary, Bongers, Angelika, primary, Terry, Rachael, primary, Ehteda, Anahid, primary, Gamble, Laura D., primary, Issaeva, Natalia, primary, Leonova, Katerina I., primary, O'Connor, Aisling, primary, Mayoh, Chelsea, primary, Venkat, Pooja, primary, Quek, Hazel, primary, Brand, Jennifer, primary, Kusuma, Frances K., primary, Pettitt, Jessica A., primary, Mosmann, Erin, primary, Kearns, Adam, primary, Eden, Georgina, primary, Alfred, Stephanie, primary, Allan, Sophie, primary, Zhai, Lei, primary, Kamili, Alvin, primary, Gifford, Andrew J., primary, Carter, Daniel R., primary, Henderson, Michelle J., primary, Fletcher, Jamie I., primary, Marshall, Glenn, primary, Johnstone, Ricky W., primary, Cesare, Anthony J., primary, Ziegler, David S., primary, Gudkov, Andrei V., primary, Gurova, Katerina V., primary, Norris, Murray D., primary, and Haber, Michelle, primary

Published
2023
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27. Supplemental Table 2 from Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers

Author

Zhang, Jialing, primary, Chen, Tony, primary, Yang, Xinping, primary, Cheng, Hui, primary, Späth, Stephan S., primary, Clavijo, Paul E., primary, Chen, Jianhong, primary, Silvin, Christopher, primary, Issaeva, Natalia, primary, Su, Xiulan, primary, Yarbrough, Wendell G., primary, Annunziata, Christina M., primary, Chen, Zhong, primary, and Van Waes, Carter, primary

Published
2023
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29. Supplementary Figures legends from Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer

Author

Biktasova, Asel, primary, Hajek, Michael, primary, Sewell, Andrew, primary, Gary, Cyril, primary, Bellinger, Gary, primary, Deshpande, Hari A., primary, Bhatia, Aarti, primary, Burtness, Barbara, primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Issaeva, Natalia, primary

Published
2023
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33. Supplementary Data from Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck

Author

Lee, Jong Woo, primary, Parameswaran, Janaki, primary, Sandoval-Schaefer, Teresa, primary, Eoh, Kyung Jin, primary, Yang, Dong-hua, primary, Zhu, Fang, primary, Mehra, Ranee, primary, Sharma, Roshan, primary, Gaffney, Stephen G., primary, Perry, Elizabeth B., primary, Townsend, Jeffrey P., primary, Serebriiskii, Ilya G., primary, Golemis, Erica A., primary, Issaeva, Natalia, primary, Yarbrough, Wendell G., primary, Koo, Ja Seok, primary, and Burtness, Barbara, primary

Published
2023
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44. Supplementary Tables 1-5 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Author

Xiao, Lin, primary, Somers, Klaartje, primary, Murray, Jayne, primary, Pandher, Ruby, primary, Karsa, Mawar, primary, Ronca, Emma, primary, Bongers, Angelika, primary, Terry, Rachael, primary, Ehteda, Anahid, primary, Gamble, Laura D., primary, Issaeva, Natalia, primary, Leonova, Katerina I., primary, O'Connor, Aisling, primary, Mayoh, Chelsea, primary, Venkat, Pooja, primary, Quek, Hazel, primary, Brand, Jennifer, primary, Kusuma, Frances K., primary, Pettitt, Jessica A., primary, Mosmann, Erin, primary, Kearns, Adam, primary, Eden, Georgina, primary, Alfred, Stephanie, primary, Allan, Sophie, primary, Zhai, Lei, primary, Kamili, Alvin, primary, Gifford, Andrew J., primary, Carter, Daniel R., primary, Henderson, Michelle J., primary, Fletcher, Jamie I., primary, Marshall, Glenn, primary, Johnstone, Ricky W., primary, Cesare, Anthony J., primary, Ziegler, David S., primary, Gudkov, Andrei V., primary, Gurova, Katerina V., primary, Norris, Murray D., primary, and Haber, Michelle, primary

Published
2023
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45. Supplementary Tables 1-2 from 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Author

Issaeva, Natalia, primary, Thomas, Huw D., primary, Djurenovic, Tatjana, primary, Jaspers, Janneke E., primary, Stoimenov, Ivaylo, primary, Kyle, Suzanne, primary, Pedley, Nicholas, primary, Gottipati, Ponnari, primary, Zur, Rafal, primary, Sleeth, Kate, primary, Chatzakos, Vicky, primary, Mulligan, Evan A., primary, Lundin, Cecilia, primary, Gubanova, Evgenia, primary, Kersbergen, Ariena, primary, Harris, Adrian L., primary, Sharma, Ricky A., primary, Rottenberg, Sven, primary, Curtin, Nicola J., primary, and Helleday, Thomas, primary

Published
2023
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46. Supplementary Figure 2 from 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Author

Issaeva, Natalia, primary, Thomas, Huw D., primary, Djurenovic, Tatjana, primary, Jaspers, Janneke E., primary, Stoimenov, Ivaylo, primary, Kyle, Suzanne, primary, Pedley, Nicholas, primary, Gottipati, Ponnari, primary, Zur, Rafal, primary, Sleeth, Kate, primary, Chatzakos, Vicky, primary, Mulligan, Evan A., primary, Lundin, Cecilia, primary, Gubanova, Evgenia, primary, Kersbergen, Ariena, primary, Harris, Adrian L., primary, Sharma, Ricky A., primary, Rottenberg, Sven, primary, Curtin, Nicola J., primary, and Helleday, Thomas, primary

Published
2023
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47. Supplementary Figure 3 from 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Author

Issaeva, Natalia, primary, Thomas, Huw D., primary, Djurenovic, Tatjana, primary, Jaspers, Janneke E., primary, Stoimenov, Ivaylo, primary, Kyle, Suzanne, primary, Pedley, Nicholas, primary, Gottipati, Ponnari, primary, Zur, Rafal, primary, Sleeth, Kate, primary, Chatzakos, Vicky, primary, Mulligan, Evan A., primary, Lundin, Cecilia, primary, Gubanova, Evgenia, primary, Kersbergen, Ariena, primary, Harris, Adrian L., primary, Sharma, Ricky A., primary, Rottenberg, Sven, primary, Curtin, Nicola J., primary, and Helleday, Thomas, primary

Published
2023
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48. Data from 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Author

Issaeva, Natalia, primary, Thomas, Huw D., primary, Djurenovic, Tatjana, primary, Jaspers, Janneke E., primary, Stoimenov, Ivaylo, primary, Kyle, Suzanne, primary, Pedley, Nicholas, primary, Gottipati, Ponnari, primary, Zur, Rafal, primary, Sleeth, Kate, primary, Chatzakos, Vicky, primary, Mulligan, Evan A., primary, Lundin, Cecilia, primary, Gubanova, Evgenia, primary, Kersbergen, Ariena, primary, Harris, Adrian L., primary, Sharma, Ricky A., primary, Rottenberg, Sven, primary, Curtin, Nicola J., primary, and Helleday, Thomas, primary

Published
2023
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49. Supplementary Figure 5 from 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Author

Issaeva, Natalia, primary, Thomas, Huw D., primary, Djurenovic, Tatjana, primary, Jaspers, Janneke E., primary, Stoimenov, Ivaylo, primary, Kyle, Suzanne, primary, Pedley, Nicholas, primary, Gottipati, Ponnari, primary, Zur, Rafal, primary, Sleeth, Kate, primary, Chatzakos, Vicky, primary, Mulligan, Evan A., primary, Lundin, Cecilia, primary, Gubanova, Evgenia, primary, Kersbergen, Ariena, primary, Harris, Adrian L., primary, Sharma, Ricky A., primary, Rottenberg, Sven, primary, Curtin, Nicola J., primary, and Helleday, Thomas, primary

Published
2023
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50. Supplementary Figure 1 from 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Author

Issaeva, Natalia, primary, Thomas, Huw D., primary, Djurenovic, Tatjana, primary, Jaspers, Janneke E., primary, Stoimenov, Ivaylo, primary, Kyle, Suzanne, primary, Pedley, Nicholas, primary, Gottipati, Ponnari, primary, Zur, Rafal, primary, Sleeth, Kate, primary, Chatzakos, Vicky, primary, Mulligan, Evan A., primary, Lundin, Cecilia, primary, Gubanova, Evgenia, primary, Kersbergen, Ariena, primary, Harris, Adrian L., primary, Sharma, Ricky A., primary, Rottenberg, Sven, primary, Curtin, Nicola J., primary, and Helleday, Thomas, primary

Published
2023
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