2,084 results on '"Issa, F."'
Search Results
2. Clinical relevance of MYC/BCL2 expression and cell of origin in patients with diffuse large b-cell lymphoma treated with autologous transplant
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Al-Juhaishi, Taha, Wang, Yingjun, Milton, Denái R., Xu-Monette, Zijun Y., Jabbour, Elias, Daher, May, Im, Jin S., Bashir, Qaiser, Iyer, Swaminathan P., Marin, David, Olson, Amanda L., Popat, Uday, Qazilbash, Muzaffar, Rondon, Gabriela, Gulbis, Alison M., Champlin, Richard E., Young, Ken H., and Khouri, Issa F.
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- 2023
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3. Parasitic neutron beam monitoring: proof of concept on gamma monitoring of neutron chopper phases
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Issa, F., Hall-Wilton, R., Quintanilla, A., Olsson, M., Zielinski, D., Kanaki, K., and Tsapatsaris, N.
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Physics - Instrumentation and Detectors - Abstract
Neutron beam monitors are an essential diagnostic component of neutron scattering facilities. They are used to measure neutron flux, calibrating experiments performed on the instruments, allowing measurement of facility performance, understanding of the effect on the neutrons of beam-line components (such as choppers), calibration of detectors and tracking of beam stability. Ideally beam monitors {should} not perturb the beam. Previous work shows commercial beam monitors attenuate the beam by a few percent in the worst case due to the 1-2 mm thick Aluminium entrance and exit windows and the material inside. Parasitic methods of neutron beam diagnostics, where there is no beam monitor directly in the beam, would be preferable. This paper presents the concept of a parasitic method of monitoring the beam which can be used for neutron chopper phasing. This is achieved by placing a gamma detector close to a rotating chopper and measures a signal proportional to the flux absorbed by the chopper. Neutrons interact with the Boron absorber on the chopper disc lead to gamma emission at 480 keV. Detection of these gamma rays is used to determine the chopper phasing and timing. Potentially information on the flux of the beamline can be extracted. Results from a proof of concept implementation show that diagnosis of neutron chopper phases is feasible., Comment: 6 pages, 8 figures. Version: accepted Euro Physics Letters
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- 2020
4. Impact of graft composition on outcomes of haploidentical bone marrow stem cell transplantation
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Saliba, Rima M, Veltri, Lauren, Rondon, Gabriela, Chen, Julianne, Al-Atrash, Gheath, Alousi, Amin, Martinez, Charles, Augustine, LaJerald, Hosing, Chitra M, Oran, Betul, Rezvani, Katayoun, Shpall, Elizabeth J, Kebriaei, Partow, Khouri, Issa F, Popat, Uday, Champlin, Richard E, and Ciurea, Stefan O
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Bone Marrow ,Bone Marrow Transplantation ,Cyclophosphamide ,Graft vs Host Disease ,Hematopoietic Stem Cell Transplantation ,Humans ,Stem Cell Transplantation ,Transplantation Conditioning ,Immunology - Published
- 2021
5. First neutron data recorded at the V20 Test Instrument utilizing prototype chopper systems and beam monitors planned for ESS
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Maulerova, V., Nilsson, J., Olsson, M., Alcock, S., Quintanilla, A., Zielinski, D., Mukai, A., Issa, F., Kolya, S., Smith, W., Broderick, D., Löki, K., Sparger, J., Woracek, R., Taylor, J., Richter, T., Hall-Wilton, R., Kirstein, O., and Tsapatsaris, N.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The main objective of the European Spallation Source (ESS) is to perform consistently high impact neutron scattering science using the highest neutron flux of any facility in its class. This ambition is naturally accompanied by operational challenges related to the vertical integration of the instruments' hardware and software shared between collaborators from 13 European countries. The present work will detail integration tests performed at the V20 Test Instrument at Helmholtz-Zentrum Berlin in Germany. An ESS chopper prototype was successfully controlled through the ESS Chopper Integration Controller (CHIC) and Experimental Physics and Industrial Control System (EPICS). Neutron data were successfully collected and time stamped using neutron beam monitors, the ESS prototype detector readout electronics and the Data Management Software Center (DMSC) data acquisition (DAQ) software. Chopper rotation events were timestamped and the chopper disk showed excellent stability and neutron absorption characteristics. The test resulted in (i) the expected time-of-flight (TOF) response, (ii) collected data that compared well with instrument reference data and (iii) revealing the diagnostic power of the performed integration tests. The results of this integration test validate the ESS chopper and detector DAQ architecture choices., Comment: 8 pages, 9 figures
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- 2019
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6. Allogeneic Transplantation after Myeloablative Rituximab/BEAM ± Bortezomib for Patients with Relapsed/Refractory Lymphoid Malignancies: 5-Year Follow-Up Results
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Chamoun, Kamal, Milton, Denái R, Ledesma, Celina, Young, Ken H, Jabbour, Elias J, Alatrash, Gheath, Anderlini, Paolo, Bashir, Qaiser, Ciurea, Stefan O, Marin, David, Molldrem, Jeffrey J, Olson, Amanda L, Oran, Betul, Popat, Uday R, Rondon, Gabriela, Champlin, Richard E, Gulbis, Alison M, and Khouri, Issa F
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Oncology and Carcinogenesis ,Rare Diseases ,Orphan Drug ,Prevention ,Hematology ,Lymphoma ,Cancer ,Transplantation ,Clinical Research ,6.2 Cellular and gene therapies ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adult ,Age Factors ,Aged ,Allografts ,Antineoplastic Combined Chemotherapy Protocols ,Bortezomib ,Carmustine ,Cytarabine ,Disease-Free Survival ,Female ,Hematologic Neoplasms ,Humans ,Lymphoma ,Large B-Cell ,Diffuse ,Male ,Melphalan ,Middle Aged ,Podophyllotoxin ,Rituximab ,Stem Cell Transplantation ,Survival Rate ,Myeloablative allogeneic transplantation ,R-BEAM ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology - Abstract
Although bortezomib and rituximab have synergistic activity in patients with lymphoma and both can attenuate graft-versus-host disease (GVHD), the drugs have not been used together in patients undergoing allogeneic stem cell transplantation (alloSCT). In this phase I/II trial, we assessed the safety and activity of bortezomib added to the rituximab (R) plus BEAM (carmustine, etoposide, cytarabine, melphalan) regimen in patients with relapsed lymphoma undergoing alloSCT. Primary GVHD prophylaxis consisted of tacrolimus and methotrexate. Bortezomib (1 to 1.3 mg/m2 per dose) was administered i.v. on days -13, -6, -1, and +2. We performed inverse probability weighting analysis to compare GVHD and survival results with an historical control group that received R-BEAM without bortezomib. Thirty-nine patients were assessable for toxic effects and response. The median age was 54 years. The most common diagnosis was diffuse large B cell lymphoma (41%). Twenty-two patients (56%) and 17 patients (44%) received their transplants from matched related and matched unrelated donors, respectively. The maximum tolerated bortezomib dose was 1 mg/m2. The weighted cumulative incidences of grades II to IV and III or IV acute GVHD were 50% and 34%, respectively; these incidences and survival rates were not significantly different from those of the control group. Median survival was not reached in patients age ≤ 50 years and with a long follow-up time of 60.7 months. The R-BEAM regimen has a survival benefit in lymphoma patients age ≤ 50 years undergoing alloSCT. The addition of bortezomib has no impact on survival or incidence of GVHD.
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- 2019
7. Impact of Donor Type and Melphalan Dose on Allogeneic Transplantation Outcomes for Patients with Lymphoma
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Saini, Neeraj Y, Saliba, Rima M, Rondon, Gabriela, Maadani, Farzaneh, Popat, Uday, Hosing, Chitra M, Oran, Betul, Bashir, Qaiser, Olson, Amanda, Nieto, Yago, Alousi, Amin, Kebriaei, Partow, Srour, Samer, Mehta, Rohtesh, Anderlini, Paolo, Shpall, Elizabeth J, Qazilbash, Muzaffar H, Khouri, Issa F, Fayad, Luis, Lee, Hun, Fowler, Nathan, Parmar, Simrit, Westin, Jason, Hagemeister, Fredrick, Champlin, Richard E, and Ciurea, Stefan O
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Oncology and Carcinogenesis ,Immunology ,Regenerative Medicine ,Transplantation ,Cancer ,Orphan Drug ,Hematology ,Rare Diseases ,Lymphoma ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Allografts ,Disease-Free Survival ,Female ,Graft vs Host Disease ,Humans ,Incidence ,Male ,Melphalan ,Middle Aged ,Retrospective Studies ,Stem Cell Transplantation ,Survival Rate ,Tissue Donors ,Vidarabine ,Allogeneic transplantation ,FM100 regimen ,Haploidentical transplantation ,Hodgkin lymphoma ,Melphalan conditioning ,Non-Hodgkin lymphoma ,Clinical Sciences ,Cardiovascular medicine and haematology - Abstract
We analyzed 186 patients with lymphoma who underwent allogeneic stem cell transplantation (ASCT) with fludarabine-melphalan (FM) conditioning and different types of donors (25 haploidentical [HD], 98 matched unrelated [MUD], and 63 matched related [MRD]) at our institution between September 2009 and January 2018. Patients received fludarabine 160 mg/m2 (40 mg/m2/day for 4 days) in combination with 1 dose of melphalan 140 mg/m2 (FM140) or 100 mg/m2 (FM100). Engraftment was similar among the 3 groups (92%, 89%, and 98%, respectively; P = .7). The 6-month cumulative incidence of grade III-IV acute graft-versus-host disease (GVHD) was 4% in the HD group, 14% in the MUD group, and 8% in the MRD group (P not significant), and the respective 3-year cumulative incidence of chronic GVHD was 5%, 16%, and 26% (P not significant). The respective 3-year nonrelapse mortality and relapse rates were 31%, 32%, and 10% (HD versus MUD, P = .9; HD versus MRD, P = .02) and 15%, 21%, and 39% (HD versus MUD, P = .4; HD versus MRD, P = .04). At 3 years, progression-free survival (PFS) was 59%, 44%, and 46% (P not significant); overall survival (OS) was 52%, 54%, and 67% (P not significant); and GVHD-free, relapse-free survival was 39%, 31%, and 24% (P not significant). No differences in the 3-year PFS (57% versus 43%; P = .3) and OS (64% versus 58%; P = .7) were seen between patients receiving FM100 and those receiving FM140. Our data demonstrate that in patients with lymphoma, ASCT with HD transplants have similar outcomes as ASCT with HLA-matched transplants, and the FM100 conditioning regimen appears to be at least as effective as the FM140 regimen.
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- 2019
8. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis
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Shankar, S., Stolp, J., Juvet, S. C., Beckett, J., Macklin, P. S., Issa, F., Hester, J., and Wood, K. J.
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- 2022
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9. A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer
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Fletcher, C. E., Deng, L., Orafidiya, F., Yuan, W., Lorentzen, M. P. G. S., Cyran, O. W., Varela-Carver, A., Constantin, T. A., Leach, D. A., Dobbs, F. M., Figueiredo, I., Gurel, B., Parkes, E., Bogdan, D., Pereira, R. R., Zhao, S. G., Neeb, A., Issa, F., Hester, J., Kudo, H., Liu, Y., Philippou, Y., Bristow, R., Knudsen, K., Bryant, R. J., Feng, F. Y., Reed, S. H., Mills, I. G., de Bono, J., and Bevan, C. L.
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- 2022
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10. Variance Analysis of Expatriate Pre-Hospital Provider Training in Bahrain
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Alnoaimi MM, Hart A, Issa F, Hertelendy A, Voskanyan A, and Ciottone G
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core competencies ,emergency medical services ,paramedics ,pre-hospital ,registered nurses ,training ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Moza M Alnoaimi,1,2 Alexander Hart,1,3 Fadi Issa,1,4 Attila Hertelendy,1,5 Amalia Voskanyan,1 Gregory Ciottone1,4 1Department of Emergency Medicine, Disaster Medicine Fellowship, Beth Israel Deaconess Medical Centre (BIDMC), Boston, MA, USA; 2Department of Emergency Medicine, Bahrain Defence Force Royal Medical Services Military Hospital, Riffa, Bahrain; 3Department of Emergency Medicine, Hartford Hospital, University of Connecticut School of Medicine, Hartford, CT, USA; 4Harvard Medical School, Harvard University, Boston, MA, USA; 5Department of Information Systems and Business Analytics, College of Business, Florida International University, Miami, FL, USACorrespondence: Moza M Alnoaimi, Fellow, Beth Israel Deaconess Medical Centre (BIDMC) Disaster Medicine fellowship, Department of Emergency Medicine, BIDMC, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA, Email dr.mozaalnoaimi@yahoo.com; m_alnuaimi_08@hotmail.comIntroduction: The absence of local Emergency Medical Services (EMS) educational programs in Bahrain has given rise to an EMS workforce comprised predominantly of expatriate personnel with varying educational backgrounds that require further training before being licensed as EMS providers in Bahrain.Methods: A qualitative variance analysis was performed comparing desired core competencies for EMS practice in neighbouring Saudi Arabia, used as a comparator for Bahrain, with core competencies extracted from national curricula of the major countries from which expatriate providers originate.Results: Major core competencies not covered by the expatriate providers’ curricula were identified as follows: working in an autonomous environment, requiring different critical thinking and decision-making skills, assessment and treatment during transportation, disaster response, EMS knowledge base, and coping with the different stressors of the prehospital environment.Conclusion: These results can form the basis for additional customized training programs for expatriate EMS providers working in Bahrain, with the goal of improving and standardizing EMS care in the country.Keywords: core competencies, emergency medical services, paramedics, pre-hospital, registered nurses, training
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- 2022
11. The neutron tagging facility at Lund University
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Messi, F., Perrey, H., Fissum, K., Akkawi, M., Jebali, R. Al, Annand, J. R. M., Bentley, P., Boyd, L., Cooper-Jensen, C. P., DiJulio, D. D., Freita-Ramos, J., Hall-Wilton, R., Huusko, A., Ilves, T., Issa, F., Jalgén, A., Kanaki, K., Karnickis, E., Khaplanov, A., Koufigar, S., Maulerova, V., Mauri, G., Mauritzson, N., Pei, W., Piscitelli, F., Rofors, E., Scherzinger, J., Söderhielm, H., Söderström, D., and Stefanescu, I.
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Physics - Instrumentation and Detectors - Abstract
Over the last decades, the field of thermal neutron detection has overwhelmingly employed He-3-based technologies. The He-3 crisis together with the forthcoming establishment of the European Spallation Source have necessitated the development of new technologies for neutron detection. Today, several promising He-3-free candidates are under detailed study and need to be validated. This validation process is in general long and expensive. The study of detector prototypes using neutron-emitting radioactive sources is a cost-effective solution, especially for preliminary investigations. That said, neutron-emitting sources have the general disadvantage of broad, structured, emitted-neutron energy ranges. Further, the emitted neutrons often compete with unwanted backgrounds of gamma-rays, alpha-particles, and fission-fragments. By blending experimental infrastructure such as shielding to provide particle beams with neutron-detection techniques such as tagging, disadvantages may be converted into advantages. In particular, a technique known as tagging involves exploiting the mixed-field generally associated with a neutron-emitting source to determine neutron time-of-flight and thus energy on an event-by-event basis. This allows for the definition of low-cost, precision neutron beams. The Source-Testing Facility, located at Lund University in Sweden and operated by the SONNIG Group of the Division of Nuclear Physics, was developed for just such low-cost studies. Precision tagged-neutron beams derived from radioactive sources are available around-the-clock for advanced detector diagnostic studies. Neutron measurements performed at the Source Testing Facility are thus cost-effective and have a very low barrier for entry. In this paper, we present an overview of the project., Comment: IAEA Technical Meeting on Modern Neutron Detection (F1-TM-55243)
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- 2017
12. Multi-Grid Detector for Neutron Spectroscopy: Results Obtained on Time-of-Flight Spectrometer CNCS
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Anastasopoulos, M., Bebb, R., Berry, K., Birch, J., Bryś, T., Buffet, J. -C., Clergeau, J. -F., Deen, P. P., Ehlers, G., van Esch, P., Everett, S. M., Guerard, B., Hall-Wilton, R., Herwig, K., Hultman, L., Höglund, C., Iruretagoiena, I., Issa, F., Jensen, J., Khaplanov, A., Kirstein, O., Lopez-Higuera, I., Piscitelli, F., Robinson, L., Schmidt, S., and Stefanescu, I.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The Multi-Grid detector technology has evolved from the proof-of-principle and characterisation stages. Here we report on the performance of the Multi-Grid detector, the MG.CNCS prototype, which has been installed and tested at the Cold Neutron Chopper Spectrometer, CNCS at SNS. This has allowed a side-by-side comparison to the performance of $^3$He detectors on an operational instrument. The demonstrator has an active area of 0.2 m$^2$. It is specifically tailored to the specifications of CNCS. The detector was installed in June 2016 and has operated since then, collecting neutron scattering data in parallel to the He-3 detectors of CNCS. In this paper, we present a comprehensive analysis of this data, in particular on instrument energy resolution, rate capability, background and relative efficiency. Stability, gamma-ray and fast neutron sensitivity have also been investigated. The effect of scattering in the detector components has been measured and provides input to comparison for Monte Carlo simulations. All data is presented in comparison to that measured by the $^3$He detectors simultaneously, showing that all features recorded by one detector are also recorded by the other. The energy resolution matches closely. We find that the Multi-Grid is able to match the data collected by $^3$He, and see an indication of a considerable advantage in the count rate capability. Based on these results, we are confident that the Multi-Grid detector will be capable of producing high quality scientific data on chopper spectrometers utilising the unprecedented neutron flux of the ESS., Comment: submitted to JINST
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- 2017
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13. Characterization of Thermal Neutron Beam Monitors
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Issa, F., Khaplanov, A., Hall-Wilton, R., Llamas, I., Riktor, M. Dalseth, Brattheim, S. R., and Perrey, H.
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Physics - Instrumentation and Detectors - Abstract
Neutron beam monitors with high efficiency, low gamma sensitivity, high time and space resolution are required in neutron beam experiments to continuously diagnose the delivered beam. In this work, commercially available neutron beam monitors have been characterized using the R2D2 beamline at IFE (Norway) and using a Be-based neutron source. For the gamma sensitivity measurements different gamma sources have been used. The evaluation of the monitors includes, the study of their efficiency, attenuation, scattering and sensitivity to gamma. In this work we report the results of this characterization., Comment: 11 pages, 19 figures
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- 2017
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14. Allogeneic hematopoietic cell transplantation for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN)
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Bashir, Qaiser, Milton, Denái R., Popat, Uday R., Kebriaei, Partow, Hosing, Chitra, Khouri, Issa F., Rezvani, Katayoun, Nieto, Yago, Oran, Betul, Srour, Samer A., Saini, Neeraj Y., Olson, Amanda L., Ahmed, Sairah, Al-Atrash, Gheath, Rondon, Gabriela, Konopleva, Marina Y., Champlin, Richard E., Shpall, Elizabeth J., Qazilbash, Muzaffar H., and Pemmaraju, Naveen
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- 2022
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15. Is a matched unrelated donor search needed for all allogeneic transplant candidates?
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Ciurea, Stefan O, Bittencourt, Maria Cecilia Borges, Milton, Denái R, Cao, Kai, Kongtim, Piyanuch, Rondon, Gabriela, Chen, Julianne, Konopleva, Marina, Perez, Jorge M Ramos, Shazly, Mohammed F El, Aljadayeh, Majdi, Alvarez, Michele, Im, Jin, Al-Atrash, Gheath, Mehta, Rohtesh, Popat, Uday, Bashir, Qaiser, Oran, Betul, Hosing, Chitra M, Khouri, Issa F, Kebriaei, Partow, and Champlin, Richard E
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Organ Transplantation ,Clinical Research ,Transplantation ,Adolescent ,Adult ,Aged ,Child ,Haplotypes ,Hematologic Neoplasms ,Hematopoietic Stem Cell Transplantation ,Histocompatibility Testing ,Humans ,Middle Aged ,Remission Induction ,Risk Factors ,Survival Analysis ,Transplantation ,Haploidentical ,Transplantation ,Homologous ,Unrelated Donors ,Young Adult ,Cardiovascular medicine and haematology - Abstract
Donor availability for allogeneic transplantation remains an important factor in determining outcomes of a successful transplant. We examined outcomes of 242 patients treated over 3 years who had a matched unrelated donor (MUD) search at our institution. One hundred sixty patients (66%) had a 10 of 10 MUD identified, and 85 (53%) proceeded to MUD transplantation. White patients and those with common haplotypes were more likely to have a MUD identified (odds ratio [OR], 7.4 [P < .0001]; OR, 41.6 [P < .0001]), and were more likely to proceed to transplantation with a MUD (OR, 11.2 [P < .0001]; OR, 85.1 [P = .002]). In addition, patients who were newly diagnosed/in remission at the time of MUD search had a higher probability of receiving a transplant (OR, 2.01 [P = .013]) and better progression-free survival (PFS; P < .0001). In multivariate analysis for patients who received a transplant, donor type did not influence PFS at 3 years, which was 40% for MUD and 57% for haploidentical transplants, respectively (hazard ratio, 1.2 [P = .50]). In conclusion, race, haplotype frequency, and disease status at the time of MUD search influence the probability of identifying a MUD and receiving a transplant. Patients with a low likelihood of receiving a MUD transplant may proceed to a haploidentical transplant as soon as indicated, as this approach does not appear to compromise transplant outcomes.
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- 2018
16. Haploidentical Transplantation for Older Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome
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Ciurea, Stefan O, Shah, Mithun V, Saliba, Rima M, Gaballa, Sameh, Kongtim, Piyanuch, Rondon, Gabriela, Chen, Julianne, Wallis, Whitney, Cao, Kai, Konopleva, Marina, Daver, Naval, Cortes, Jorge, Ravandi, Farhad, Alousi, Amin, Ahmed, Sairah, Popat, Uday, Parmar, Simrit, Bashir, Qaiser, Betul, Oran, Hosing, Chitra, Shpall, Elizabeth J, Rezvani, Katayoun, Khouri, Issa F, Kebriaei, Partow, and Champlin, Richard E
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Immunology ,Hematology ,Regenerative Medicine ,Transplantation ,Stem Cell Research ,Pediatric Cancer ,Stem Cell Research - Nonembryonic - Human ,Orphan Drug ,Pediatric ,Childhood Leukemia ,Clinical Research ,Stem Cell Research - Nonembryonic - Non-Human ,Cancer ,Rare Diseases ,Aging ,6.1 Pharmaceuticals ,Aetiology ,Evaluation of treatments and therapeutic interventions ,2.1 Biological and endogenous factors ,Adult ,Aged ,Cyclophosphamide ,Graft vs Host Disease ,Humans ,Leukemia ,Myeloid ,Acute ,Middle Aged ,Myelodysplastic Syndromes ,Risk Factors ,Transplantation Conditioning ,Transplantation ,Haploidentical ,Treatment Outcome ,Haploidentical stem cell transplant ,Post-transplant cyclophosphamide ,Elderly patients ,Acute myeloid leukemia ,Myelodysplastic syndrome ,Clinical Sciences ,Cardiovascular medicine and haematology - Abstract
Allogeneic stem cell transplantation with HLA-matched donors is increasingly used for older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). It remains unclear if haploidentical stem cell transplantation (haploSCT) is a suitable option for older patients with this disease. We analyzed 43 patients with AML/MDS (median age, 61 years) who underwent a haploSCT at our institution. All patients received a fludarabine-melphalan-based reduced-intensity conditioning regimen and post-transplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis. Except for 1 patient who had early death, the remaining 42 patients (98%) engrafted donor cells. The cumulative incidences of grades II to IV and III to IV acute GVHD at 6 months were 35% and 5%, respectively, and chronic GVHD at 2 years was 9%. After a median follow-up of 19 months, 2-year overall survival, progression-free survival (PFS), and relapse incidence were 42%, 42%, and 24%, respectively. Best PFS (74% at 2 years) was seen in patients with intermediate-/good-risk cytogenetics, in first or second remission (hazard ratio, .4; P = .05), and with a younger donor (≤40 years; hazard ratio, .2; P = .01). In conclusion, these data suggest that haploidentical transplantation is safe and effective for older AML/MDS patients. Disease status, cytogenetics, and younger donor age are predictors for improved survival in older patients receiving a haploidentical transplant.
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- 2018
17. Development of high peak and average power Tm:YLF lasers
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Hubka, Zbynek, primary, Tamer, Issa F., additional, Kiani, Leily S., additional, Owens, Jason W., additional, Church, Andrew J., additional, Batysta, František, additional, Galvin, Tom, additional, Willard, Drew, additional, Yandow, Andrew, additional, Chemali, Alex, additional, Galbraith, Justin D., additional, Alessi, David, additional, Harthcock, Colin, additional, Hickman, Brad, additional, Jackson, Candis, additional, Nissen, James, additional, Tardif, Sean, additional, Nguyen, Hoang, additional, Neurath, Hansel, additional, Sistrunk, Emily, additional, Plummer, Robert E., additional, Reagan, Brendan A., additional, and Spinka, Thomas M., additional
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- 2024
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18. Randomized phase II trial of extracorporeal phototherapy and steroids vs. steroids alone for newly diagnosed acute GVHD
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Mehta, Rohtesh S., Bassett, Roland, Rondon, Gabriela, Overman, Bethany J., Popat, Uday R., Hosing, Chitra M., Rezvani, Katy, Qazilbash, Muzaffar H., Anderlini, Paolo, Jones, Roy B., Kebriaei, Partow, Marin, David, Khouri, Issa F., Oran, Betul, Ciurea, Stefan O., Kondo, Kayo, Couriel, Daniel R., Shpall, Elizabeth J., Champlin, Richard E., and Alousi, Amin M.
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- 2021
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19. Correlations of Heat Transfer and Fluid Flow Data for Lattice Brick Settings in Tunnel Kilns
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Issa F. Almesri, Mosab A. Alrahmani, Jaber H. Almutairi, and Hosny Z. Abou-Ziyan
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tunnel kilns ,lattice brick setting ,CFD models ,Nusselt number ,friction factor ,surface roughness ,Technology - Abstract
This paper proposes correlation equations of heat transfer and pressure drop for the design and operation of tunnel kilns loaded with lattice brick settings of different geometrical parameters in the form of Nusselt number and friction factor. The developed correlation equations considered parameters that were not investigated in previous studies, such as the relative roughness of the bricks and the stack channels, and they also extended the Reynolds numbers to a practical range that was not covered before in a simple, practical form. The correlation equations are valid for Reynolds number between 125 and 10,200, Prandtl number between 0.68 and 0.73, brick’s relative roughness between 0.23 and 0.93, voidage fraction between 0.48 and 0.653, and the geometrical parameters of the tested lattice brick settings. The achieved correlations of the Nusselt number and the friction factor are well compared with the available correlations in the literature in their valid range of parameters. It is found that Nusselt numbers and the friction factors for low-density are higher than those of high-density settings for all considered parameters except the voidage fraction. The effect of the considered parameters confirms that Nusselt numbers increase and the friction factors decrease substantially with the Reynolds number and slightly with the Prandtl number. At a constant Reynolds number, both the Nusselt number and the friction factor increase as the brick’s relative roughness is increased. Moreover, as the stack channel spacing is increased, the Nusselt number decreases, and the friction factor increases. The voidage fraction of the setting has a monotonic effect on both Nusselt numbers and friction factors. Nusselt numbers for high-density are higher than those for low-density settings as the voidage fraction varies.
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- 2023
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20. Age Is a Prognostic Factor for the Overall Survival of Patients with Multiple Myeloma Undergoing Upfront Autologous Hematopoietic Stem Cell Transplantation
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Cordas dos Santos, David M., Saliba, Rima M., Patel, Romil, Bashir, Qaiser, Saini, Neeraj, Hosing, Chitra, Kebriaei, Partow, Khouri, Issa F., Nieto, Yago, Popat, Uday, Ahmed, Haris, Lee, Hans C., Manasanch, Elisabet E., Patel, Krina K., Thomas, Sheeba K., Weber, Donna M., Orlowski, Robert Z., Champlin, Richard E., and Qazilbash, Muzaffar H.
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- 2020
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21. Outcome of Multiple Myeloma with Chromosome 1q Gain and 1p Deletion after Autologous Hematopoietic Stem Cell Transplantation: Propensity Score Matched Analysis
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Varma, Ankur, Sui, Dawen, Milton, Denái R., Tang, Guilin, Saini, Neeraj, Hasan, Omar, Mukherjee, Akash, Joseph, Jacinth Joy, Bashir, Qaiser, Rondon, Gabriela, Srour, Samer, Popat, Uday R., Hosing, Chitra M., Nieto, Yago, Kebriaei, Partow, Alousi, Amin M., Ahmed, Sairah, Mehta, Rohtesh, Khouri, Issa F., Ahmed, Haris, Iyer, Swaminathan, Weber, Donna M., Thomas, Sheeba K., Manasanch, Elisabet, Lee, Hans C., Patel, Krina, Ciurea, Stefan O., Shpall, Elizabeth J., Orlowski, Robert Z., Champlin, Richard E., and Qazilbash, Muzaffar H.
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- 2020
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22. Incidence and Risk Factors of Early Onset VOD/SOS Differ in Younger vs Older Adults After Stem Cell Transplantation
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Marcoux, Curtis, primary, Saliba, Rima M, additional, Wallis, Whitney, additional, Khazal, Sajad J, additional, Ragoonanan, Dristhi, additional, Rondon, Gabriela, additional, Tewari, Priti, additional, Popat, Uday R., additional, Oran, Betul, additional, Olson, Amanda L, additional, Bashir, Qaiser, additional, Qazilbash, Muzaffar H, additional, Alousi, Amin, additional, Hosing, Chitra, additional, Nieto, Yago, additional, Alatrash, Gheath, additional, Marin, David C, additional, Rezvani, Katayoun, additional, Khouri, Issa F., additional, Srour, Samer A, additional, Champlin, Richard E., additional, Shpall, Elizabeth J, additional, and Kebriaei, Partow, additional
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- 2024
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23. Online Labs in Modern Engineering Education: Global Reality or Restricted Concept?
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Batarseh, M.G., primary, Alqudah, R. K., additional, and El issa, F. B., additional
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- 2023
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24. Working Temperature’s Influence on the Lifepo4 Battery Generated Power
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Issa, F., primary, Diaconu, E.M., additional, and Ardeleanu, M.N., additional
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- 2023
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25. Outcomes of Patients With Chronic Lymphocytic Leukemia and Richter's Transformation After Transplantation Failure
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Rozovski, Uri, Benjamini, Ohad, Jain, Preetesh, Thompson, Philip A, Wierda, William G, O'Brien, Susan, Burger, Jan A, Ferrajoli, Alessandra, Faderl, Stefan, Shpall, Elizabeth, Hosing, Chitra, Khouri, Issa F, Champlin, Richard, Keating, Michael J, and Estrov, Zeev
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Oncology and Carcinogenesis ,Genetics ,Cancer ,Transplantation ,Hematology ,Rare Diseases ,Orphan Drug ,Clinical Research ,Lymphoma ,Adenine ,Adult ,Aged ,Antineoplastic Agents ,Chronic Disease ,Disease Progression ,Factor Analysis ,Statistical ,Female ,Graft vs Host Disease ,Humans ,Kaplan-Meier Estimate ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Piperidines ,Pyrazoles ,Pyrimidines ,Recurrence ,Retrospective Studies ,Risk Factors ,Salvage Therapy ,Stem Cell Transplantation ,Transplantation Conditioning ,Transplantation ,Homologous ,Treatment Failure ,Treatment Outcome ,Clinical Sciences ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
PurposeAllogeneic stem-cell transplantation (SCT) induces long-term remission in a fraction of patients with high-risk chronic lymphocytic leukemia (CLL) or Richter's transformation (RT). Our purpose was to determine the outcomes of patients whose disease progressed after allogeneic SCT.Patients and methodsWe retrospectively analyzed the outcomes of 72 patients (52 with CLL and 20 with RT) who underwent allogeneic SCT between 1998 and 2011 and had documented progression after transplantation. Twenty-two (31%) never had a response, and 50 (69%) had a response but experienced relapse after a median of 7 months (range, 2 to 85 months). Forty-eight patients who were receiving or were candidates to receive post-SCT cell-based therapies were not included in this analysis.ResultsThe median age at time of transplantation was 58 years (range, 30 to 72 years). Sixty-two patients (86%) received more than two treatment regimens and 37 (51%) received more than three treatment regimens before SCT. Sixty-six patients (92%) had active disease at the time of transplantation. The 2- and 5-year survival rates were 67% and 38% (patients with CLL) and 36% and 0% (patients with RT). The patients who developed acute or chronic graft-versus-host disease had a longer overall survival (OS; P = .05). In a multivariable analysis, RT or low hemoglobin at the time of SCT predicted shorter OS. Chronic graft-versus-host disease and an initial response to SCT predicted longer OS.ConclusionPatients with CLL in whom allogeneic SCT fails may have a response to and benefit from salvage therapies, and their prognosis is relatively good.
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- 2015
26. Allogeneic stem cell transplant in patients with chronic lymphocytic leukemia with 17p deletion: consult-transplant versus consult- no-transplant analysis
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Poon, Michelle L, Fox, Patricia S, Samuels, Barry I, O’Brien, Susan, Jabbour, Elias, Hsu, Yvonne, Gulbis, Alison, Korbling, Martin, Champlin, Richard, Abruzzo, Lynne V, Bassett, Roland L, and Khouri, Issa F
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Stem Cell Research ,Cancer ,Stem Cell Research - Nonembryonic - Human ,Clinical Research ,Lymphoma ,Rare Diseases ,Hematology ,Transplantation ,Adult ,Aged ,Chromosome Deletion ,Chromosomes ,Human ,Pair 17 ,Female ,Follow-Up Studies ,Graft vs Host Disease ,Humans ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Referral and Consultation ,Retrospective Studies ,Stem Cell Transplantation ,Survival Analysis ,Survival Rate ,Time Factors ,Transplantation ,Homologous ,Treatment Outcome ,17p− ,CLL ,allogeneic transplant ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology - Abstract
Allogeneic stem cell transplant (alloSCT) can overcome the adverse prognosis of chronic lymphocytic leukemia with 17p deletion (17p- CLL). However, its applicability remains unclear. Since 2007, our leukemia service has referred patients with 17p- CLL for alloSCT at presentation. In this study, the outcomes of these patients were reviewed retrospectively to determine whether they underwent alloSCT and why patients did not undergo alloSCT. Fifty-two patients with 17p- CLL who were referred to the transplant service from 2007 to 2010 were identified. Of these patients, 32 (62%) did not undergo alloSCT, mainly because of treatment- or disease-related complications (n = 15). The 2-year post-referral overall survival rates of the alloSCT and non-SCT groups were 64% and 25%, respectively (p = 0.001). These findings suggest that while alloSCT is an effective therapy in patients with 17p- CLL, pre-SCT complications may preclude a significant proportion of patients from undergoing the procedure.
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- 2015
27. Impact of Donor Type and Melphalan Dose on Allogeneic Transplantation Outcomes for Patients with Lymphoma
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Saini, Neeraj Y., Saliba, Rima M., Rondon, Gabriela, Maadani, Farzaneh, Popat, Uday, Hosing, Chitra M., Oran, Betul, Bashir, Qaiser, Olson, Amanda, Nieto, Yago, Alousi, Amin, Kebriaei, Partow, Srour, Samer, Mehta, Rohtesh, Anderlini, Paolo, Shpall, Elizabeth J., Qazilbash, Muzaffar H., Khouri, Issa F., Fayad, Luis, Lee, Hun, Fowler, Nathan, Parmar, Simrit, Westin, Jason, Hagemeister, Fredrick, Champlin, Richard E., and Ciurea, Stefan O.
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- 2019
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28. Safety and long‐term survival results of the addition of inotuzumab ozogamicin to the conditioning regimen of allogeneic stem cell transplantation: A single‐center phase 1,2 trial.
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Khouri, Issa F., Alzahrani, Kamal, Kantarjian, Hagop, Milton, Denái R., Gulbis, Alison M., Sasaki, Koji, Jain, Nitin, Short, Nicholas J., Kadia, Tapan, Daher, May, Rafei, Hind, Im, Jin S., Marin, David, Olson, Amanda L., Popat, Uday, Qazilbash, Muzaffar, Ramdial, Jeremy, Rondon, Gabriela, Srour, Samer, and Kebriaei, Partow
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- 2024
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29. Adopting Cost Effective Cutting-Edge Technology to Mitigate Cemented Annulus Pressure and Reduce Carbon Footprint
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Abdi, R. M., additional, Alhosani, A. H., additional, Sumaida, Ali. S. Bin, additional, Ahmad, M. H., additional, Alshehhi, H., additional, Altamimi, A., additional, Issa, F. H., additional, Elrefai, F. M. A., additional, Barker, D., additional, and Murty, M. J., additional
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- 2023
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30. Haploidentical Transplantation for Older Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome
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Ciurea, Stefan O., Shah, Mithun V., Saliba, Rima M., Gaballa, Sameh, Kongtim, Piyanuch, Rondon, Gabriela, Chen, Julianne, Wallis, Whitney, Cao, Kai, Konopleva, Marina, Daver, Naval, Cortes, Jorge, Ravandi, Farhad, Alousi, Amin, Ahmed, Sairah, Popat, Uday, Parmar, Simrit, Bashir, Qaiser, Betul, Oran, Hosing, Chitra, Shpall, Elizabeth J., Rezvani, Katayoun, Khouri, Issa F., Kebriaei, Partow, and Champlin, Richard E.
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- 2018
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31. The outcomes of patients with chronic myeloid leukemia treated with third‐line <scp>BCR</scp> :: <scp>ABL1</scp> tyrosine kinase inhibitors
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Elias J. Jabbour, Koji Sasaki, Fadi G. Haddad, Ghayas C. Issa, Guillermo Garcia‐Manero, Tapan M. Kadia, Nitin Jain, Musa Yilmaz, Courtney D. DiNardo, Keyur P. Patel, Rashmi Kanagal‐Shamanna, Richard Champlin, Issa F. Khouri, Sara Dellasala, Sherry A. Pierce, and Hagop Kantarjian
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Hematology - Published
- 2023
32. Effect of fluid channels on flow uniformity in complex geometry similar to lattice brick setting in tunnel kilns
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Almutairi, Jaber H., Alrahmani, Mosab A., Almesri, Issa F., and Abou-Ziyan, Hosny Z.
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- 2017
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33. Impact of Fluid Overload as New Toxicity Category on Hematopoietic Stem Cell Transplantation Outcomes
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Rondón, Gabriela, Saliba, Rima M., Chen, Julianne, Ledesma, Celina, Alousi, Amin M., Oran, Betul, Hosing, Chitra M., Kebriaei, Partow, Khouri, Issa F., Shpall, Elizabeth J., Popat, Uday R., Champlin, Richard E., and Ciurea, Stefan O.
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- 2017
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34. Impact of graft composition on outcomes of haploidentical bone marrow stem cell transplantation
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Rima M. Saliba, Lauren Veltri, Gabriela Rondon, Julianne Chen, Gheath Al-Atrash, Amin Alousi, Charles Martinez, LaJerald Augustine, Chitra M. Hosing, Betul Oran, Katayoun Rezvani, Elisabeth J. Shpall, Partow Kebriaei, Issa F. Khouri, Uday Popat, Richard E. Champlin, and Stefan O. Ciurea
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2020
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35. Myeloablative Fractionated Busulfan for Allogeneic Stem Cell Transplant in Older Patients or Patients with Comorbidities
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Popat, Uday R., primary, Pasvolsky, Oren, additional, Bassett, Roland, additional, Mehta, Rohtesh S, additional, Olson, Amanda L, additional, Chen, Julianne, additional, Alousi, Amin Majid, additional, Al-Atrash, Gheath, additional, Bashir, Qaiser, additional, Gulbis, Alison M, additional, Hosing, Chitra M, additional, Im, Jin S, additional, Kebriaei, Partow, additional, Khouri, Issa F., additional, Marin, David C, additional, Nieto, Yago, additional, Oran, Betul, additional, Saini, Neeraj Y, additional, Shigle, Terri Lynn, additional, Srour, Samer A, additional, Ramdial, Jeremy Leon, additional, Rezvani, Katayoun, additional, Qazilbash, Muzaffar H, additional, Andersson, Borje S, additional, Champlin, Richard E., additional, and Shpall, Elizabeth J, additional
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- 2023
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36. On Generators and Undirected Cayley graphs of Γ_1-Non-Deranged Permutation Groups
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Aremu, K. O., primary, Issa, F. A., additional, Muhammad, A., additional, Tasiu, A.R., additional, and Muhammed, I.M., additional
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- 2023
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37. Delivering Bad News: Can We Do Better?
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Pikkel, Joseph, Issa, F., Ben Shoushan, Y., Zarka, Salman, editor, and Lerner, Alexander, editor
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- 2017
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38. Regulatory T-cell therapy approaches
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McCallion, O, Bilici, M, Hester, J, and Issa, F
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Immunology ,Immunology and Allergy - Abstract
Summary Regulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex vivo expanded autologous Tregs continues to progress through mid- to late-phase clinical trials in several disease spaces and has generated promising preliminary safety and efficacy signals to date. However, the practicalities of this strategy outside of the clinical trial setting remain challenging. Here, we review the current landscape of regulatory T-cell therapy, considering emergent approaches and technologies presenting novel ways to engage Tregs, and reflect on the progress necessary to deliver their therapeutic potential to patients.
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- 2022
39. Correlations of Heat Transfer and Fluid Flow Data for Lattice Brick Settings in Tunnel Kilns
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Almesri, Issa F., primary, Alrahmani, Mosab A., additional, Almutairi, Jaber H., additional, and Abou-Ziyan, Hosny Z., additional
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- 2023
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40. Supplementary Data from Impact of Autologous Transplantation in Patients with Multiple Myeloma with t(11;14): A Propensity-Score Matched Analysis
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Saini, Neeraj, primary, Ma, Junsheng, primary, Milton, Denái R., primary, Patel, Romil, primary, Varma, Ankur, primary, Bashir, Qaiser, primary, Delgado, Ruby, primary, Mukherjee, Akash, primary, Rondon, Gabriela, primary, Popat, Uday R., primary, Hosing, Chitra M., primary, Nieto, Yago, primary, Kebriaei, Partow, primary, Alousi, Amin M., primary, Ahmed, Sairah, primary, Tang, Guilin, primary, Mehta, Rohtesh, primary, Srour, Samer, primary, Khouri, Issa F., primary, Iyer, Swaminathan, primary, Weber, Donna M., primary, Thomas, Sheeba K., primary, Lee, Hans C., primary, Manasanch, Elisabet E., primary, Patel, Krina K., primary, Orlowski, Robert Z., primary, Champlin, Richard E., primary, and Qazilbash, Muzaffar H., primary
- Published
- 2023
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41. Figure A1 from Updated Results of Rituximab Pre- and Post-BEAM with or without 90Yttrium Ibritumomab Tiuxetan during Autologous Transplant for Diffuse Large B-cell Lymphoma
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Chahoud, Jad, primary, Sui, Dawen, primary, Erwin, William D., primary, Gulbis, Alison M., primary, Korbling, Martin, primary, Zhang, Mingzhi, primary, Ahmed, Sairah, primary, Alatrash, Gheath, primary, Anderlini, Paolo, primary, Ciurea, Stefan O., primary, Oran, Betul, primary, Fayad, Luis E., primary, Bassett, Roland L., primary, Jabbour, Elias J., primary, Medeiros, L. Jeffrey, primary, Macapinlac, Homer A., primary, Young, Ken H., primary, and Khouri, Issa F., primary
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- 2023
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42. Table A1 from Updated Results of Rituximab Pre- and Post-BEAM with or without 90Yttrium Ibritumomab Tiuxetan during Autologous Transplant for Diffuse Large B-cell Lymphoma
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Chahoud, Jad, primary, Sui, Dawen, primary, Erwin, William D., primary, Gulbis, Alison M., primary, Korbling, Martin, primary, Zhang, Mingzhi, primary, Ahmed, Sairah, primary, Alatrash, Gheath, primary, Anderlini, Paolo, primary, Ciurea, Stefan O., primary, Oran, Betul, primary, Fayad, Luis E., primary, Bassett, Roland L., primary, Jabbour, Elias J., primary, Medeiros, L. Jeffrey, primary, Macapinlac, Homer A., primary, Young, Ken H., primary, and Khouri, Issa F., primary
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- 2023
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43. Computerized adaptive testing for the patient evaluation measure (PEM) in patients undergoing cubital tunnel syndrome surgery.
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Teunissen, J.S., Hovius, S.E.R., Ulrich, D.J.O., Issa, F., Rodrigues, J.N., Harrison, C.J., Teunissen, J.S., Hovius, S.E.R., Ulrich, D.J.O., Issa, F., Rodrigues, J.N., and Harrison, C.J.
- Abstract
Contains fulltext : 300051.pdf (Publisher’s version ) (Open Access), In outcome measures, item response theory (IRT) validation can deliver interval-scaled high-quality measurement that can be harnessed using computerized adaptive tests (CATs) to pose fewer questions to patients. We aimed to develop a CAT by developing an IRT model for the Patient Evaluation Measure (PEM) for patients undergoing cubital tunnel syndrome (CuTS) surgery. Nine hundred and seventy-nine completed PEM responses of patients with CuTS in the United Kingdom Hand Registry were used to develop and calibrate the CAT. Its performance was then evaluated in a simulated cohort of 1000 patients. The CAT reduced the original PEM length from ten to a median of two questions (range two to four), while preserving a high level of precision (median standard error of measurement of 0.27). The mean error between the CAT score and full-length score was 0.08%. A Bland-Altman analysis showed good agreement with no signs of bias. The CAT version of the PEM can substantially reduce patient burden while enhancing construct validity by harnessing IRT for patients undergoing CuTS surgery., 01 november 2023
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- 2023
44. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
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Adisa, A, Bahrami-Hessari, M, Bhangu, A, George, C, Ghosh, D, Glasbey, J, Haque, P, Ingabire, J, Kamarajah, S, Kudrna, L, Ledda, V, Li, E, Lillywhite, R, Mittal, R, Nepogodiev, D, Ntirenganya, F, Picciochi, M, Simões, J, Booth, L, Elliot, R, Kennerton, A, Pettigrove, K, Pinney, L, Richard, H, Tottman, R, Wheatstone, P, Wolfenden, J, Smith, A, Sayed, A, Goswami, A, Malik, A, Mclean, A, Hassan, A, Nazimi, A, Aladna, A, Abdelgawad, A, Saed, A, Abdelmageed, A, Ghannam, A, Mahmoud, A, Alvi, A, Ismail, A, Adesunkanmi, A, Ebrahim, A, Al-Mallah, A, Alqallaf, A, Durrani, A, Gabr, A, Kirfi, A, Altaf, A, Almutairi, A, Sabbagh, A, Ajiya, A, Haddud, A, Alnsour, A, Singh, A, Mittal, A, Semple, A, Adeniran, A, Negussie, A, Oladimeji, A, Muhammad, A, Yassin, A, Gungor, A, Tarsitano, A, Soibiharry, A, Dyas, A, Frankel, A, Peckham-Cooper, A, Truss, A, Issaka, A, Ads, A, Aderogba, A, Adeyeye, A, Ademuyiwa, A, Sleem, A, Papa, A, Cordova, A, Appiah-Kubi, A, Meead, A, Nacion, A, Michael, A, Forneris, A, Duro, A, Gonzalez, A, Altouny, A, Ghazal, A, Khalifa, A, Ozair, A, Quzli, A, Haddad, A, Othman, A, Yahaya, A, Elsherbiny, A, Nazer, A, Tarek, A, Abu-Zaid, A, Al-Nusairi, A, Azab, A, Elagili, A, Elkazaz, A, Kedwany, A, Nuhu, A, Sakr, A, Shehta, A, Shirazi, A, Mohamed, A, Sherif, A, Awad, A, Abbas, A, Abdelrahman, A, Ammar, A, Azzam, A, Ciftci, A, Dural, A, Sanli, A, Rahy-Martín, A, Tantri, A, Khan, A, Al-Touny, A, Tariq, A, Gmati, A, Costas-Chavarri, A, Auerkari, A, Landaluce-Olavarria, A, Puri, A, Radhakrishnan, A, Ubom, A, Pradhan, A, Turna, A, Adepiti, A, Kuriyama, A, Kassam, A, Hassouneh, A, El-Hussuna, A, Habeebullah, A, Mousli, A, Biloslavo, A, Hoang, A, Kirk, A, Santini, A, Melero, A, Calvache, A, Baduell, A, Chan, A, Abrate, A, Balduzzi, A, Sánchez, A, Navarrete-Peón, A, Porcu, A, Brolese, A, Barranquero, A, Saibene, A, Adam, A, Vagge, A, Maquilón, A, Leon-Andrino, A, Sekulić, A, Trifunovski, A, Mako, A, Bedada, A, Broglia, A, Coppola, A, Giani, A, Grandi, A, Iacomino, A, Moro, A, D’Amico, A, Malagnino, A, Tang, A, Doyle, A, Alfieri, A, Haynes, A, Wilkins, A, Baldwin, A, Heriot, A, Laird, A, Lazarides, A, O'Connor, A, Trulson, A, Rokohl, A, Caziuc, A, Triantafyllou, A, Anesi, A, Nikova, A, Andrianakis, A, Charalabopoulos, A, Tsolakidis, A, Chirca, A, Arnaud, A, Narvaez-Rojas, A, Kavalakat, A, Spina, A, Recordare, A, Annicchiarico, A, Conti, A, Mohammed, A, Kocataş, A, Almhimid, A, Arnaout, A, Fahmy, A, Mangi, A, Modabber, A, Ulas, A, Mohamedahmed, A, Frontali, A, Moynihan, A, Yunus, A, Ahmad, A, Kent, A, Khamees, A, Ugwu, A, Turan, A, Navarro-Barrios, A, Yebes, A, De Sousa, Á, Moreno, A, Sethi, A, Dawson, A, Kaur, A, Wolde, A, Antonelli, A, Scifo, A, Alhamad, A, Davis, A, Alderazi, A, Harky, A, Mohammed-Durosinlorun, A, Seguya, A, Okhakhu, A, Chamakhi, A, Sebai, A, Souadka, A, Asla, A, Agrawal, A, Persad, A, Gupta, A, Elgazar, A, Kulkarni, A, Coates, A, Bellés, A, Hadzibegovic, A, Jotic, A, Kowark, A, Martins, A, Pineda, A, Peral, A, Gollarte, A, Senent-Boza, A, Camarena, A, Castaño-Leon, A, Bravo, A, Musina, A, Tapia-Herrero, A, Kothari, A, Raja, A, Aljaiuossi, A, Taha, A, Majbar, A, Prodromidou, A, Kanatas, A, Gupte, A, Zakaria, A, Balla, A, Barberis, A, Bondurri, A, Bottari, A, Costantino, A, Figus, A, Lauretta, A, Mingoli, A, Romanzi, A, Sagnotta, A, Scacchi, A, Picchetto, A, Valadez, A, Luzzi, A, Älgå, A, Fontalis, A, Hecker, A, Demetriades, A, Serban, A, Văcărașu, A, Cokan, A, Isaza-Restrepo, A, Beamish, A, Schache, A, Stevenson, A, Yiu, A, Cockbain, A, Litvin, A, Abad-Motos, A, Becerra, A, Ramos, Á, Chiaradia, A, Dell, A, Romano, A, Pascale, A, Marra, A, Dimas, A, Kolias, A, Cerovac, A, Koneru, A, Tidjane, A, Agbeko, A, Bajaj, A, Gosain, A, Allan, A, Carreras-Castañer, A, D'Amore, A, Dare, A, Maffioli, A, Palepa, A, Paspala, A, Konney, A, Gatta, A, Ezanno, A, Yiallourou, A, Kinnair, A, Rayner, A, Scafa, A, Bowan, A, Veglia, A, Russo, A, Maniaci, A, Castaldi, A, Gil-Moreno, A, Maffuz-Aziz, A, Meola, A, Nenna, A, Ferrer, A, Bonilla, A, Ramos-De La Medina, A, Infante, A, Santoro, A, Laganà, A, Bateman, A, Abozid, A, Seidu, A, Lowery, A, Tantraworasin, A, Rasheed, A, Picciariello, A, Isik, A, Saif, A, Anjum, A, Ioannidis, A, Abeldaño, A, Hussain, A, Nathan, A, Bedzhanyan, A, Perfecto, A, De Virgilio, A, Galvan, A, Sablotzki, A, Böttcher, A, Pellacani, A, Gatti, A, Ibrahimli, A, Menon, A, Sahni, A, Mwenda, A, Choudhry, A, Jayawardane, A, Ramasamy, A, Mitul, A, Bawa, A, Nugur, A, Rammohan, A, Sachdeva, A, Mehraj, A, Yildirim, A, Alqaseer, A, Radwan, A, Sallam, A, Syllaios, A, Tampakis, A, Alwael, A, Samara, A, Eroglu, A, Rahman, A, Ulkucu, A, Zaránd, A, Dulskas, A, Tawiah, A, Zani, A, Vas, A, Lukosiute-Urboniene, A, Adamu, A, Aujayeb, A, İplikçi, A, Mahmud, A, Cil, A, Makanjuola, A, Akwaisah, A, Galandarova, A, Saracoglu, A, Regan, A, Barlas, A, Alhassan, B, Mostafa, B, Hamida, B, Torun, B, Abdullah, B, Balagobi, B, Banky, B, Singh, B, Alegbeleye, B, Yigit, B, Hajjaj, B, Burgos-Blasco, B, Seeliger, B, Alayande, B, 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Sungurtekin, H, Junior, H, Moloo, H, Bayhan, H, Şevi̇k, H, Embarek, H, Hamid, H, Pradeep, I, Donkin, I, Ateca, I, Jafarov, I, Salisu, I, Abdalaal, I, Garzali, I, Sall, I, Adebara, I, Aghadi, I, Ugwu, I, Zapardiel, I, Reis, I, Nwafor, I, Fakhradiyev, I, Surya, I, Robo, I, Njokanma, I, Iannone, I, Khan, I, Correia, I, Königsrainer, I, Seiwerth, I, Linero, I, Kadiri, I, Florian, I, Tzima, I, Akrida, I, Baloyiannis, I, Gerogiannis, I, Katsaros, I, Tsakiridis, I, Valioulis, I, Negoi, I, Yadev, I, De Haro Jorge, I, Vázquez, I, Dajti, I, Russo, I, Afzal, I, Wasserman, I, Chukwu, I, Gracia, I, Oliver, I, Hughes, I, Mondi, I, Ncogoza, I, Bsisu, I, Rashid, I, Balasubramanian, I, Omar, I, Dominguez-Rosado, I, Smati, I, Vokshi, I, Al-Badawi, I, Saleh, I, Pilkington, I, Kirac, I, Trostchansky, I, Gawron, I, Trebol, J, Martellucci, J, Andreuccetti, J, Abou-Khalil, J, Shah, J, Manickavasagam, J, De Alarcón, J, Mihanovic, J, O'Riordan, J, Archer, J, Ashcroft, J, Blair, J, Hamill, J, Munthali, J, Park, 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Maguire, Patrick J, Petrone, Patrizio, Cullis, Paul, Köglberger, Paul, Marriott, Paul, Nankivell, Paul, Santos-Costa, Paulo, Martins, Paulo N, Panahi, Pedram, Botelho, Pedro, Teixeira, Pedro, Escobar, Pedro, Vázquez, Pedro José Gil, Gribnev, Petar, Nolte, Peter, Agbonrofo, Peter, Bobak, Peter, Choong, Peter, Elbe, Peter, Hutchinson, Peter, Labib, Peter, Paal, Peter, Pockney, Peter, Reemst, Peter, Szatmary, Peter, Vaughan-Shaw, Peter G, Alexander, Philip, Pucher, Philip, Stather, Philip, Foessleitner, Philipp, Winnand, Philipp, Zehnder, Philipp, Kruse, Philippe, Matos, Philomena Alice Wawer, Lapolla, Pierfrancesco, Cicerchia, Pierfranco Maria, Solli, Piergiorgio, Di Lascio, Pierpaolo, Zarif, Pierre, Champagne, Pierre-Olivier, Anoldo, Pietro, Bertoglio, Pietro, Fransvea, Pietro, Familiari, Pietro, Lombardi, Pietro Maria, Stogowski, Piotr Tomasz, Bruzzaniti, Placido, Tripathi, Prashant, D'sa, Prashanth, Salunke, Pravin, Shah, Pritik A, Punjabi, Prof Prakash P, Christodoulou, Prokopis, 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Sreelakshmi, Croghan, Stefanie M, Turi, Stefano, Capella, Stefano, Lucchini, Stefano, Magnone, Stefano, Salizzoni, Stefano, Scabini, Stefano, Scaringi, Stefano, Cioffi, Stefano Piero Bernardo, Seyfried, Steffen, Degener, Stephan, Potten, Stephanie, Taha-Mehlitz, Stephanie, Ali, Stephen, Angamuthu, Stephen, Mcaleer, Stephen, Knight, Stephen Richard, White, Stuart, Mantziari, Styliani, Kykalos, Stylianos, Goh, Su Kah, Chowdhury, Subhadip Pal, Ibrahim, Sufyan, Elzwai, Suha, Bansal, Sujesh, Tripathy, Sujit, Amrayev, Sultan, Anwar, Sumadi Lukman, Banerjee, Sumit, Thakar, Sumit, Saeed, Summaya, Venkatappa, Sunil Kumar, Das, Sunit, Techapongsatorn, Suphakarn, Dube, Surya Kumar, Lee, Susan, González-Suárez, Susana, Henriques, Susana, Konjevoda, Suzana, Gisbertz, Suzanne, Bravo, Sybil Lizanne, Mannan, Syed, Bukhari, Syed Imran, Zafar, Syed Nabeel, Batista, Sylvia, Chin, Synn Lynn, Arif, Tahera, Lawal, Taiwo Akeem, Aktokmakyan, Talar Vartanoglu, Osborn, Tamara, Szakmany, Tamas, Sztipits, Tamás, 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Muntaser Abu, Aljiffry, Murad, Kalın, Murat, Kurawa, Musbahu, Dincer, Müserref Beril, Tolani, Musliu Adetola, Soytas, Mustafa, Yakubu, Mustapha, Usman, Mustapha Ibrahim, Aremu, Muyiwa, Paranyak, Mykola, Talat, Nabila, Kausar, Nabila, Dudi-Venkata, Nagendra, Bazzi, Nagham, Hasan, Najat Ben, Van Wyk, Naomi Natasha, Shaban, Naseebah, Almgla, Naser, Kandevani, Naser Yousefzadeh, Alzerwi, Nasser, Alvarez, Natalia, Motas, Natalia, Rincón, Natalia Andrea Rivera, Blencowe, Natalie, Simon, Natalie, Aghtarafi, Natasha, Ghuman, Navdeep Kaur, Sharma, Naveen, Wijekoon, Naveen, Kumar, Navin, Hassan, Naya, Onyemaechi, Ndubuisi, Prijović, Nebojša, Özçay, Necdet, Goel, Neha, Segaren, Neil, Sharma, Neil, Kalyva, Nektaria, Palacios, Nelson Morales, Alonso, Nestor Fabian Pedraza, Onyeagwara, Ngozi, Petrucciani, Niccolò, Daddi, Niccolo’, Lightfoot, Nicholas, Power, Nicholas, Segaren, Nicholas, Starr, Nichole, Dreger, Nici Markus, Cillara, Nicola, Colucci, Nicola, Eardley, Nicola, Tartaglia, Nicola, Zanini, Nicola, Bacalbasa, Nicolae, Campuzano, Nicolas, Mouawad, Nicolas, Federico, Nicoletta Sveva Pipitone, Tamini, Nicolò, Mariani, Nicolò Maria, Beasley, Nigel, Adu-Aryee, Nii Armah, Burlov, Nikita, Dimitrokallis, Nikolaos, Gouvas, Nikolaos, Machairas, Nikolaos, Memos, Nikolaos, Thomakos, Nikolaos, Tsakiridis, Nikolaos, Schizas, Nikolaos, Börner, Nikolaus, Theochari, Nikoletta, Al-Saadi, Nina, Glass, Nina, Horesh, Nir, R, Nissi Evelyn, Gahlot, Nitesh, Ismail, Nizar, Aljirdabi, Noof, Maria, Noor Ul Huda, Trabulsi, Nora, Akeel, Nouf, Borges, Nuno, Moda, Nupur, Redondo, Nuria Villacé, Nyarko, Obed Ofori, Ginghina, Octav, Enciu, Octavian, Okere, Oghenekevwe, Ekwunife, Okechukwu Hyginus, Quadri, Oladeji, Ogundoyin, Olakayode, Tucker, Olga, Mateo-Sierra, Olga, Azzis, Olivier, Ojewuyi, Olufemi, Habeeb, Olufemi, Idowu, Olufemi, Elebute, Olumide, Agboola, Oluseyi, Ladipo-Ajayi, Oluwaseun, Oyinloye, Oluwaseun, Adebola, Oluwaseyi, Ekor, Oluwayemisi, Ogundoyin, Oluwole, Salamanca, Omar, 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Pazmiño, Patricio Andrés Freile, Coughlin, Patrick, Kirchweger, Patrick, Pessaux, Patrick, Maguire, Patrick J, Petrone, Patrizio, Cullis, Paul, Köglberger, Paul, Marriott, Paul, Nankivell, Paul, Santos-Costa, Paulo, Martins, Paulo N, Panahi, Pedram, Botelho, Pedro, Teixeira, Pedro, Escobar, Pedro, Vázquez, Pedro José Gil, Gribnev, Petar, Nolte, Peter, Agbonrofo, Peter, Bobak, Peter, Choong, Peter, Elbe, Peter, Hutchinson, Peter, Labib, Peter, Paal, Peter, Pockney, Peter, Reemst, Peter, Szatmary, Peter, Vaughan-Shaw, Peter G, Alexander, Philip, Pucher, Philip, Stather, Philip, Foessleitner, Philipp, Winnand, Philipp, Zehnder, Philipp, Kruse, Philippe, Matos, Philomena Alice Wawer, Lapolla, Pierfrancesco, Cicerchia, Pierfranco Maria, Solli, Piergiorgio, Di Lascio, Pierpaolo, Zarif, Pierre, Champagne, Pierre-Olivier, Anoldo, Pietro, Bertoglio, Pietro, Fransvea, Pietro, Familiari, Pietro, Lombardi, Pietro Maria, Stogowski, Piotr Tomasz, Bruzzaniti, Placido, Tripathi, Prashant, D'sa, 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Sara, Konswa, Sara, Mambrilla, Sara, Nasser, Sara, Parini, Sara, Pitoni, Sara, Ornaghi, Sara, Rodrigues, Sara Castanheira, Abdelmohsen, Sarah, Aitken, Sarah, Tian, Sarah, Badiani, Sarit, Ahmad, Sarwat, Swed, Sarya, Muthu, Sathish, Lakpriya, Sathya, Alzahrani, Saud, Mikalauskas, Saulius, Lasrado, Savita, Satoskar, Savni, Bawa, Sayesha, Altiner, Saygin, Garcia, Sean, Stevens, Sean, Demir, Sebahattin, Ken-Amoah, Sebastian, Tranca, Sebastian, Ziemann, Sebastian, Awad, Selmy, Atici, Semra Demirli, Subramaniam, Sentilnathan, Erel, Serap, Jiang, Serena, Efetov, Sergey, Efremov, Sergey, Katorkin, Sergey, Valladares, Sergio Chávez, Contreras, Sergio Marcos, Meriç, Serhat, Zenger, Serkan, Safi, Seyer, Leventoğlu, Sezai, Elsalhawy, Shady, Shaikh, Shafaque, Sheik, Shahila, Islam, Shahnoor, Shamim, Shahzad, Waqar, Shahzad Hussain, Ahmad, Shahzaib, Farid, Shahzaib, Seraj, Shaikh Sanjid, Sundarraju, Shalini, Karandikar, Sharad, Sambhwani, Sharan, Chopra, Sharat, Chowdhury, Sharfuddin, Laura, Sharon, Ahmed, Sharwany, Wason, Shaun, Tan, Shawn Jia Hwang, Fraser, Sheila, Williams, Shekinah, Ghozy, Sherief, Abdelmawgoud, Sherif, Shehata, Sherif, Sharma, Shilpa, Ahmed, Shima, Al-Touny, Shimaa A, Ramzanali, Shireen, Nah, Shireen Anne, Jansen, Shirley, Rajan, Shiv, Dindyal, Shiva, Amin, Shivang, Ahmad, Shoaib, Shoukrie, Shoukrie I M, Karar, Shoura, Patkar, Shraddha, Abdulsalam, Shuaib, Lin, Shuxun, Hegde, Siddhi, Fiorelli, Silvia, Quaresima, Silvia, Redondo, Silvia Villacé, Palmisano, Silvia, Ruggiero, Silvia, Balogun, Simon, Cais, Simon, Cole, Simon, Federer, Simon, Le Roux, Simon, Ippoliti, Simona, Meneghini, Simona, Viola, Simona, Manfredelli, Simone, Novello, Simone, Gananadha, Sivakumar, Mesli, Smain Nabil, Kale, Smruti, Tani, Sobhana Iftekhar, Malik, Sobia, Anastasiadou, Sofia, Boligo, Sofia, Esposito, Sofia, Valanci, Sofia, Xenaki, Sofia, Pejkova, Sofija, Bandyopadhyay, Soham, Trungu, Sokol, Basu, Somprakas, Alkhatib, Sondos, Pérez-Bertólez, Sonia, Flores, Sonia Lopez, Donoghue, Sophie, Lunca, Sorinel, Orsoo, Soyombo, Potamianos, Spyridon, Devarakonda, Sreekar, Suresh, Sreelakshmi, Croghan, Stefanie M, Turi, Stefano, Capella, Stefano, Lucchini, Stefano, Magnone, Stefano, Salizzoni, Stefano, Scabini, Stefano, Scaringi, Stefano, Cioffi, Stefano Piero Bernardo, Seyfried, Steffen, Degener, Stephan, Potten, Stephanie, Taha-Mehlitz, Stephanie, Ali, Stephen, Angamuthu, Stephen, Mcaleer, Stephen, Knight, Stephen Richard, White, Stuart, Mantziari, Styliani, Kykalos, Stylianos, Goh, Su Kah, Chowdhury, Subhadip Pal, Ibrahim, Sufyan, Elzwai, Suha, Bansal, Sujesh, Tripathy, Sujit, Amrayev, Sultan, Anwar, Sumadi Lukman, Banerjee, Sumit, Thakar, Sumit, Saeed, Summaya, Venkatappa, Sunil Kumar, Das, Sunit, Techapongsatorn, Suphakarn, Dube, Surya Kumar, Lee, Susan, González-Suárez, Susana, Henriques, Susana, Konjevoda, Suzana, Gisbertz, Suzanne, Bravo, Sybil Lizanne, Mannan, Syed, Bukhari, Syed Imran, Zafar, Syed Nabeel, Batista, Sylvia, Chin, Synn Lynn, Arif, Tahera, Lawal, Taiwo Akeem, Aktokmakyan, Talar Vartanoglu, Osborn, Tamara, Szakmany, Tamas, Sztipits, Tamás, Triantafyllou, Tania, Valadez, Tania Abigail Cueto, Singh, Tanveer, Khaliq, Tanwir, Patel, Tapan, Fadalla, Tarig, Jichi, Tarik, Sammour, Tarik, Al-Shaiji, Tariq, Naggs, Taryn, Barišić, Tatjana, Nikolouzakis, Taxiarchis, Bisgin, Tayfun, Perra, Teresa, Uprak, Tevfik Kıvılcım, Dagklis, Themistoklis, Liakakos, Theodore, Sidiropoulos, Theodoros, Adjeso, Theophilus Justus Kofi, Dölker, Theresa, Oung, Thida, Aherne, Thomas, Diehl, Thomas, Pinkney, Thomas, Raymond, Thomas, Rhomberg, Thomas, Schmitz-Rixen, Thomas, Madhuri, Thumuluru Kavitha, Lohmann, Tibor Karl, Yeoh, Tien, Zaimis, Tilemachos, Bright, Tim, Vilz, Tim O, Glowka, Tim R, Board, Timothy, Hardcastle, Timothy, Cohnert, Tina, Mahečić, Tina Tomić, William, Tinka George, Klatte, Tobias, Abbott, Tom, Watcyn-Jones, Tom, Mendes, Tome, Kulis, Tomislav, Sečan, Tomislav, Campagnaro, Tommaso, Frisoni, Tommaso, Simoncini, Tommaso, Violante, Tommaso, Safranovs, Toms Janis, Risteski, Toni, Pang, Tony, Akinyemi, Tosin, Yotsov, Tsanko, Laeke, Tsegazeab, Kochiyama, Tsukasa, Sholadoye, Tunde T, Alekberli, Tural, Ezomike, Uchechukwu, Giustizieri, Ugo, Grossi, Ugo, Köksoy, Ülkü Ceren, Bork, Ulrich, Kisser, Ulrich, Ronellenfitsch, Ulrich, Saeed, Umar, Bracale, Umberto, Jayarajah, Umesh, Rauf, Umme Habiba Abdul, Bumbasirevic, Uros, Ferrer, Ursula María Jariod, Ahmed, Usama, Bello, Usman Mohammed, Jogiat, Uzair, Sadia, Uzma, Galandarov, Vagif, Narayanan, Vairavan, Calu, Valentin, Bianchi, Valentina, Ciniero, Valeria, Tonini, Valeria, Silvestri, Vania, Vijay, Vardhini, Dewan, Varun, Lohsiriwat, Varut, Thuduvage, Vasanthika, Mousafeiris, Vasileios, Dragisic, Vedran, Sasireka, Veerasamy, Santric, Veljko, Kusuma, Venkata Ramana Murthy, Kolli, Venkata Satish, Alonso, Veronica, De Simone, Veronica, Picotti, Veronica, Martínez, Verónica Martín, Panduro-Correa, Vicky, Kakotkin, Victor, Angulo, Victor Pinto, Turrado-Rodriguez, Victor, Krishnamoorthy, Vijay, Ban, Vin Shen, Shah, Vinay, Maiola, Vincenza, Giordano, Vincenzo, La Vaccara, Vincenzo, Lizzi, Vincenzo, Papagni, Vincenzo, Schiavone, Vincenzo, Satchithanantham, Vinojan, Garcia-Virto, Virginia, Jimenez, Virginia, Kumar, Vishal, Shelat, Vishal, Bhat, Vivek, Sodhai, Vivek, Graziadei, Vivien, Kutuzov, Vladislav, Stoyanov, Vladislav, Oktseloglou, Vlasios, Flis, Vojko, Elhassan, Wael Atif Fadl, Yang, Wah, Soon, Wai Cheong, Tashkandi, Wail, Al-Khyatt, Waleed, Mabood, Waleed, Bijou, Walid, Wijenayake, Wasantha, D, Wasim, Krawczyk, Wiktor, Atkins, William, Bolton, William, White, William, Ceelen, Wim, Vagena, Xanthoula, Gozal, Yaacov, Baba, Yabasin Iddrisu, Subramani, Yamini, Jansen, Yanina, Mittal, Yash, Kara, Yasi̇n, Zwain, Yasir, Noureldin, Yasser, Alawneh, Yazan, Aydin, Yener, Lam, Yick Ho, Tang, Yita, Lim, Yizhe, Dean, Yomna, Tanas, Yousef, Su, Yu-Xiong, Fujimoto, Yuki, Altinel, Yuksel, Frolova, Yulia, Oshodi, Yusuf, Fadel, Zahir T, Zahid, Zahra, Elahi, Zain, Djama, Zakarya, Zaheen, Zakia, Jawad, Zaynab, Demetrashvili, Zaza, Gebremeskel, Zersenay, Gudisa, Zewdie, Alyami, Ziyad, Garoufalia, Zoe, Li, Zoe, Zimak, Zoran, Radin, Zorana, and Balogh, Zsolt J
- Abstract
Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was coprioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.
- Published
- 2023
45. Treatment with Hypomethylating Agents before Allogeneic Stem Cell Transplant Improves Progression-Free Survival for Patients with Chronic Myelomonocytic Leukemia
- Author
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Kongtim, Piyanuch, Popat, Uday, Jimenez, Antonio, Gaballa, Sameh, El Fakih, Riad, Rondon, Gabriela, Chen, Julianne, Bueso-Ramos, Carlos, Borthakur, Gautam, Pemmaraju, Naveen, Garcia-Manero, Guillermo, Kantarjian, Hagop, Alousi, Amin, Hosing, Chitra, Anderlini, Paolo, Khouri, Issa F., Kebriaei, Partow, Andersson, Borje S., Oran, Betul, Rezvani, Katayoun, Marin, David, Shpall, Elizabeth J., Champlin, Richard E., and Ciurea, Stefan O.
- Published
- 2016
- Full Text
- View/download PDF
46. Clinical relevance of MYC/BCL2 expression and cell of origin in patients with diffuse large b-cell lymphoma treated with autologous transplant
- Author
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Taha Al-Juhaishi, Yingjun Wang, Denái R. Milton, Zijun Y. Xu-Monette, Elias Jabbour, May Daher, Jin S. Im, Qaiser Bashir, Swaminathan P. Iyer, David Marin, Amanda L. Olson, Uday Popat, Muzaffar Qazilbash, Gabriela Rondon, Alison M. Gulbis, Richard E. Champlin, Ken H. Young, and Issa F. Khouri
- Subjects
Transplantation ,Hematology - Published
- 2023
47. Opportunities for high-plex spatial transcriptomics in solid organ transplantation
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Cross, AR, Gartner, L, Hester, J, and Issa, F
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Transplantation - Abstract
The last 5 y have seen the development and widespread adoption of high-plex spatial transcriptomic technology. This technique detects and quantifies mRNA transcripts in situ, meaning that transcriptomic signatures can be sampled from specific cells, structures, lesions, or anatomical regions while conserving the physical relationships that exist within complex tissues. These methods now frequently implement next-generation sequencing, enabling the simultaneous measurement of many targets, up to and including the whole mRNA transcriptome. To date, spatial transcriptomics has been foremost used in the fields of neuroscience and oncology, but there is potential for its use in transplantation sciences. Transplantation has a clear dependence on biopsies for diagnosis, monitoring, and research. Transplant patients represent a unique cohort with multiple organs of interest, clinical courses, demographics, and immunosuppressive regimens. Obtaining high complexity data on the disease processes underlying rejection, tolerance, infection, malignancy, and injury could identify new opportunities for therapeutic intervention and biomarker identification. In this review, we discuss currently available spatial transcriptomic technologies and how they can be applied to transplantation.
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- 2023
48. SARS-CoV-2-Specific T Cell Responses Are Not Associated with Protection against Reinfection in Hemodialysis Patients
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Shankar, S, Beckett, J, Tipton, T, Ogbe, A, Kasanyinga, M, Dold, C, Lumley, S, Dengu, F, Rompianesi, G, Elgilani, F, Longet, S, Deeks, A, Payne, RP, Duncan, CJA, Richter, A, de Silva, TI, Turtle, L, Bull, K, Barnardo, M, Friend, PJ, Dunachie, SJ, Hester, J, Issa, F, Barnes, E, Carroll, MW, Klenerman, P, Shankar, Sushma, Beckett, Joseph, Tipton, Tom, Ogbe, Ane, Kasanyinga, Mwila, Dold, Christina, Lumley, Sheila, Dengu, Fungai, Rompianesi, Gianluca, Elgilani, Faysal, Longet, Stephanie, Deeks, Alexandra, Payne, Rebecca P, Duncan, Christopher J A, Richter, Alex, de Silva, Thushan I, Turtle, Lance, Bull, Katherine, Barnardo, Martin, Friend, Peter J, Dunachie, Susanna J, Hester, Joanna, Issa, Fadi, Barnes, Eleanor, Carroll, Miles W, and Klenerman, Paul
- Subjects
hemodialysi ,Nephrology ,Renal Dialysis ,SARS-CoV-2 ,Reinfection ,T-Lymphocytes ,Research Letter ,T cell ,COVID-19 ,Humans ,General Medicine ,protection - Abstract
Patients on hemodialysis (HD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mount poor neutralizing antibody responses after two-dose vaccination. Although serological responses have been associated with reduced rates of reinfection, the relationship between cellular immunogenicity and protection has not been established. We report, for the first time, high incidence of reinfection in patients on HD who are vaccine naive (25%), which identifies that T cell responses do not predict protection against reinfection. Instead, patients on HD who went on to become reinfected had mounted highly variable and sometimes robust proliferative T cell responses to a broad array of SARS-CoV-2 peptide pools during the primary infection. The understanding that SARS-CoV-2–specific T cell responses are not predictive of protection against future infection will be a critical issue when measuring clinical efficacy of vaccination in these vulnerable cohorts, particularly when facing rapidly emerging variants of concern.
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- 2023
49. Data from Impact of Autologous Transplantation in Patients with Multiple Myeloma with t(11;14): A Propensity-Score Matched Analysis
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Muzaffar H. Qazilbash, Richard E. Champlin, Robert Z. Orlowski, Krina K. Patel, Elisabet E. Manasanch, Hans C. Lee, Sheeba K. Thomas, Donna M. Weber, Swaminathan Iyer, Issa F. Khouri, Samer Srour, Rohtesh Mehta, Guilin Tang, Sairah Ahmed, Amin M. Alousi, Partow Kebriaei, Yago Nieto, Chitra M. Hosing, Uday R. Popat, Gabriela Rondon, Akash Mukherjee, Ruby Delgado, Qaiser Bashir, Ankur Varma, Romil Patel, Denái R. Milton, Junsheng Ma, and Neeraj Saini
- Abstract
Purpose:Patients with multiple myeloma with t(11;14) have been considered to have standard-risk disease. However, several recent reports have shown contradictory results. We identified 95 patients with multiple myeloma with t(11;14) on FISH studies, who underwent upfront autologous hematopoietic stem cell transplant (auto-HCT) at our center. We compared their outcome with a group of standard-risk patients with multiple myeloma who had diploid cytogenetics by both conventional cytogenetics (CC) and FISH (n = 287).Experimental Design:To reduce the bias between the groups, we performed a 1:1 propensity score matching technique for analysis. A total of 160 patients, 80 in each group, were identified. Patients in the 2 groups were matched for age, International staging system stage at diagnosis, serum creatinine at presentation, disease status at auto-HCT, type of preparative regimens, dose of melphalan used for conditioning, and induction and maintenance regimens.Results:Patients in t(11;14) group had a post auto-HCT overall response rate (ORR) of 97.5% (78/80), compared with 100% (80/80) in the standard-risk control group (P = 0.50). Complete response rate in the t(11;14) group was 35% (28/80), compared with 45% (36/80) in the standard-risk control group (P = 0.26). The 4-year PFS rates were 40.8% (95% CI, 29.6%–56.1%) and 51.1% (95% CI, 39.4%–66.3%) in the t(11;14) and standard-risk control groups, respectively (P = 0.14). The 4-year OS rates were 74.9% (95% CI, 63.3%–88.7%) and 88.3% (95% CI, 80.4%–97.0%) in the t(11;14) and standard-risk control groups, respectively (P = 0.17). Also, patients with t(11;14) with concurrent cytogenetics had significantly poor PFS and OS compared with a propensity matched standard-risk control group.Conclusions:Our study confirms that t(11;14) multiple myeloma undergoing upfront autologous transplantation had similar outcomes as patients with multiple myeloma with normal cytogenetic and FISH studies. Existence of additional genomic aberrations by CC or FISH was associated with a worse outcome.
- Published
- 2023
50. Figure A1 from Updated Results of Rituximab Pre- and Post-BEAM with or without 90Yttrium Ibritumomab Tiuxetan during Autologous Transplant for Diffuse Large B-cell Lymphoma
- Author
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Issa F. Khouri, Ken H. Young, Homer A. Macapinlac, L. Jeffrey Medeiros, Elias J. Jabbour, Roland L. Bassett, Luis E. Fayad, Betul Oran, Stefan O. Ciurea, Paolo Anderlini, Gheath Alatrash, Sairah Ahmed, Mingzhi Zhang, Martin Korbling, Alison M. Gulbis, William D. Erwin, Dawen Sui, and Jad Chahoud
- Abstract
Progression-free survival curves for groups A, B, C, and D.
- Published
- 2023
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