3,028 results on '"Israel, E"'
Search Results
2. Plasma-assisted manipulation of vanadia nanoclusters for efficient selective catalytic reduction of NOx
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Yin, Yong, Luo, Bingcheng, Li, Kezhi, Moskowitz, Benjamin M., Mosevitzky Lis, Bar, Wachs, Israel E., Zhu, Minghui, Sun, Ye, Zhu, Tianle, and Li, Xiang
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- 2024
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3. Noise modelling and mitigation for broadband in‐door power line communication systems
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Ogunlade M. Adegoke, Saheed Lekan Gbadamosi, Babatunde S. Adejumobi, Israel E. Owolabi, Wasiu Adeyemi Oke, and Nnamdi I. Nwulu
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additive white Gaussian noise ,impulse noise ,modulation ,noise ,Telecommunication ,TK5101-6720 - Abstract
Abstract Communication systems are greatly hampered by many disruptive noises in powerline communication systems (PLC), which come with strong interference, resulting in the malfunction of PLC systems. Hence, there is a need to model noise and its effect on communication systems. This paper presents noise modelling and mitigation techniques for indoor broadband powerline communication systems. To model the PLC noise, frequency domain measurements employing the GSP‐930 spectrum analyser were carried out to determine the noise frequency response in the frequency range of 1–30 MHz. The results obtained were plotted. While the analytical model for the noise model is presented, furthermore, noise mitigation techniques for multiple input multiple output PLC (MIMO‐PLC) systems in the form of spatial modulation PLC systems have been proposed. The SM‐PLC system employs the indices of the individual transmit lines to increase the data rate, as opposed to the traditional MIMO‐PLC systems, where the symbol to be transmitted is transmitted by duplicating the symbol across all lines. The proposed system uses the maximum likelihood (ML) detector at the receiver to obtain estimates of the transmitted symbols. The simulation results of the SM‐PLC system are compared with the already existing MIMO‐PLC system and show a significant improvement of ≈6 dB and 5.2 dB in signal‐to‐noise ratio (SNR) at a bit error rate of 10(−5) for spectral efficiencies of 4 bits per channel use (bpcu) and 6 bpcu, respectively. On comparison of the SM‐PLC system having a combination of additive white Gaussian noise and impulse noise at the receiver, the SM‐PLC system outperformed the traditional MIMO‐PLC by 3.5 and 3.8 dB in SNR for 4 and 6 bpcu, respectively.
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- 2024
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4. Case report on activated PI3K-delta syndrome
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Israel E. Crisanto-López, Alan A. Pérez-Arzola, Yazmin Hernández-Castañeda, Reyna G. Carrasco-Trinidad, Aurea Vera-Loaiza, Berenice Jiménez-Pérez, Tania A. Guzmán-Santiago, Pablo O. Rodríguez-Hurtado, Wilbert Salazar-Bonilla, and Daniela Juárez-Melchor
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Activated phosphoinositide 3-kinase δ syndrome. Gain of function mutation. Primary immunodeficiency disease. Inborn errors of immunity. Case report. ,Pediatrics ,RJ1-570 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Activated phosphoinositide 3-kinase delta syndrome (APDS) [OMIM 615513] is an inborn error of immunity with autosomal dominant inheritance caused by a pathogenic variant in the PIK3CD gene. The prevalence ratio of APDS is < 1: 1,000,000 newborns. The main clinical features of APDS are sinopulmonary infections, benign lymphoproliferation, autoinflammatory disease, and a major risk of lymphoid neoplasms. Clinical case: A 17-year-old female with a history of pneumonia at 9 months of age subsequently developed recurrent respiratory tract infections, bronchiectasis, perforated otitis media, unilateral tonsillar lymphoid hyperplasia, pansinusitis, recurrent oral candidiasis, and chronic rhinitis. Laboratory studies reported persistent leukopenia and lymphopenia, low CD4 lymphocyte subpopulation, and persistently elevated immunoglobulin M immunoglobulin studies with values up to 692 mg/dL. An inborn error of immunity next-generation sequencing and multiplex ligation-dependent probe amplification analysis detected a heterozygous pathogenic variant in the PIK3CD gene, compatible with APDS. Treatment with monthly injectable gamma globulin and prophylactic antibiotics was started, allowing better control of the infectious processes. Conclusion: This is the second case of APDS reported in Mexico in the literature. It is important to be aware of this condition to make a timely diagnosis, which requires a high clinical suspicion and immunological and genetic studies to provide adequate treatment and prevent complications.
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- 2024
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5. Plasma-assisted manipulation of vanadia nanoclusters for efficient selective catalytic reduction of NOx
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Yong Yin, Bingcheng Luo, Kezhi Li, Benjamin M. Moskowitz, Bar Mosevitzky Lis, Israel E. Wachs, Minghui Zhu, Ye Sun, Tianle Zhu, and Xiang Li
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Science - Abstract
Abstract Supported nanoclusters (SNCs) with distinct geometric and electronic structures have garnered significant attention in the field of heterogeneous catalysis. However, their directed synthesis remains a challenge due to limited efficient approaches. This study presents a plasma-assisted treatment strategy to achieve supported metal oxide nanoclusters from a rapid transformation of monomeric dispersed metal oxides. As a case study, oligomeric vanadia-dominated surface sites were derived from the classic supported V2O5-WO3/TiO2 (VWT) catalyst and showed nearly an order of magnitude increase in turnover frequency (TOF) value via an H2-plasma treatment for selective catalytic reduction of NO with NH3. Such oligomeric surface VO x sites were not only successfully observed and firstly distinguished from WOx and TiO2 by advanced electron microscopy, but also facilitated the generation of surface amide and nitrates intermediates that enable barrier-less steps in the SCR reaction as observed by modulation excitation spectroscopy technologies and predicted DFT calculations.
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- 2024
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6. Structure and reactivity of surface vanadia sites in bi-layered supported VOx/AlOx/SiO2 catalysts via solid-state NMR, first-principles calculations, and catalytic studies
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Lapina, Olga B., Khabibulin, Dzhalil F., Shubin, Aleksandr A., Papulovskiy, Evgeniy, Terskikh, Victor V., and Wachs, Israel E.
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- 2024
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7. A Study of Free Surface Agitation in a Shipyard Using Numerical Modeling
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Israel E. Herrera, Arturo Galván, Jatziri Y. Moreno-Martínez, and Edith A. Gamiño
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shipyards ,free surface elevation ,numerical modeling ,statistical analysis ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
In recent years, the Port of Topolobampo, Sinaloa, Mexico, has experienced unusual free sea surface elevations, particularly during the months of November and December, affecting the shipyard areas, service docks, and berthing locations. This study focuses on analyzing the oscillatory behavior of free surface elevations in shipyard regions. A hydrodynamic model was employed to simulate the circulation and sea surface agitation, aiming to quantify the elevation magnitudes based on oceanographic and meteorological data from November of the preceding year. A 30-day numerical simulation was conducted, revealing the velocity fields associated with coastal currents and tides during November, as well as the interaction between incident waves and wave transformations due to protective structures. The results demonstrated accurate behavior in 95% of the simulation period, while anomalous elevations exceeding those specified in the design and operational guidelines of the Port of Topolobampo were observed during the final five days of the simulation. An ANOVA test was performed between the surface elevation and vertically integrated velocity to assess whether the deviations in the last five days were statistically significant compared to the rest of the simulation period. With a P-value of less than 0.05, the null hypothesis of no difference was rejected, confirming a significant variation. These findings suggest that the extreme values recorded should be considered for the potential redesign of shipyard infrastructure.
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- 2024
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8. Temperature-Programmed (TP) Techniques
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Jehng, Jih-Mirn, Wachs, Israel E., Ford, Michael, Merkle, Dieter, Managing Editor, Wachs, Israel E., editor, and Bañares, Miguel A., editor
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- 2023
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9. Case Studies: Low Energy Ion Scattering (LEIS) Spectroscopy
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Wachs, Israel E., Ford, Michael, Mosevitzky-Lis, Bar, Merkle, Dieter, Managing Editor, Wachs, Israel E., editor, and Bañares, Miguel A., editor
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- 2023
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10. Lithium carbonate-promoted mixed rare earth oxides as a generalized strategy for oxidative coupling of methane with exceptional yields
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Kun Zhao, Yunfei Gao, Xijun Wang, Bar Mosevitzky Lis, Junchen Liu, Baitang Jin, Jacob Smith, Chuande Huang, Wenpei Gao, Xiaodong Wang, Xin Wang, Anqing Zheng, Zhen Huang, Jianli Hu, Reinhard Schömacker, Israel E. Wachs, and Fanxing Li
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Science - Abstract
Abstract The oxidative coupling of methane to higher hydrocarbons offers a promising autothermal approach for direct methane conversion, but its progress has been hindered by yield limitations, high temperature requirements, and performance penalties at practical methane partial pressures (~1 atm). In this study, we report a class of Li2CO3-coated mixed rare earth oxides as highly effective redox catalysts for oxidative coupling of methane under a chemical looping scheme. This catalyst achieves a single-pass C2+ yield up to 30.6%, demonstrating stable performance at 700 °C and methane partial pressures up to 1.4 atm. In-situ characterizations and quantum chemistry calculations provide insights into the distinct roles of the mixed oxide core and Li2CO3 shell, as well as the interplay between the Pr oxidation state and active peroxide formation upon Li2CO3 coating. Furthermore, we establish a generalized correlation between Pr4+ content in the mixed lanthanide oxide and hydrocarbons yield, offering a valuable optimization strategy for this class of oxidative coupling of methane redox catalysts.
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- 2023
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11. Overview of the catalytic properties of bulk unsupported and supported group 4–5-6 oxides
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Wachs, Israel E.
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- 2024
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12. Author Correction: Plasma-assisted manipulation of vanadia nanoclusters for efficient selective catalytic reduction of NOx
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Yong Yin, Bingcheng Luo, Kezhi Li, Benjamin M. Moskowitz, Bar Mosevitzky Lis, Israel E. Wachs, Minghui Zhu, Ye Sun, Tianle Zhu, and Xiang Li
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Science - Published
- 2024
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13. Tezepelumab Efficacy in Patients with Severe, Uncontrolled Asthma with Comorbid Nasal Polyps in NAVIGATOR
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Laidlaw TM, Menzies-Gow A, Caveney S, Han JK, Martin N, Israel E, Lee JK, Llanos JP, Megally A, Parikh B, Vong S, Welte T, and Corren J
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chronic rhinosinusitis ,nasal polyps ,snot-22 ,thymic stromal lymphopoietin ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Tanya M Laidlaw1,2 *, Andrew Menzies-Gow3 *, Scott Caveney,4 Joseph K Han,5 Nicole Martin,6,7 Elliot Israel,8 Jason K Lee,9,10 Jean-Pierre Llanos,11 Neil Martin,12,13 Ayman Megally,14 Bhavini Parikh,14 Sylvia Vong,15 Tobias Welte,16 Jonathan Corren17 1Jeff and Penny Vinik Center for Allergic Diseases Research, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Boston, MA, USA; 2Department of Medicine, Harvard Medical School, Boston, MA, USA; 3Royal Brompton and Harefield Hospitals, School of Immunology and Microbial Sciences, King’s College London, London, UK; 4Global Development, Inflammation, R&D, Amgen, Thousand Oaks, CA, USA; 5Department of Otolaryngology, Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA, USA; 6Biometrics, Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA; 7Cytel Inc, Waltham, MA, USA; 8Divisions of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 9Evidence Based Medical Educator Inc., Toronto, ON, Canada; 10Toronto Allergy and Asthma Clinic, Toronto, ON, Canada; 11Global Medical Affairs, Amgen, Thousand Oaks, CA, USA; 12Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK; 13University of Leicester, Leicester, UK; 14Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; 15Translational Science and Experimental Medicine, Early Respiratory and Immunology, AstraZeneca, Gaithersburg, MD, USA; 16Department of Respiratory Medicine and German Center for Lung Research, Hannover Medical School, Hannover, Germany; 17David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA*These authors contributed equally to this workCorrespondence: Tanya M Laidlaw, Jeff and Penny Vinik Center for Allergic Diseases Research, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, 60 Fenwood Road, Boston, MA, 02115, USA, Email tlaidlaw@bwh.harvard.eduPurpose: Tezepelumab, a human monoclonal antibody, blocks thymic stromal lymphopoietin. In the phase 3 NAVIGATOR study (NCT03347279), tezepelumab reduced annualized asthma exacerbation rates (AAERs) versus placebo, irrespective of baseline disease characteristics, and improved lung function and symptom control versus placebo in adults and adolescents with severe, uncontrolled asthma. We assessed the efficacy of tezepelumab in patients with severe asthma with or without nasal polyps (NPs) in the 2 years before randomization in NAVIGATOR.Methods: Patients with severe asthma (N=1059) were randomized (1:1) and received tezepelumab 210 mg or placebo every 4 weeks subcutaneously for 52 weeks. Prespecified exploratory analyses included: AAER over 52 weeks and changes from baseline to week 52 in pre-bronchodilator forced expiratory volume in 1 second, Sino-Nasal Outcome Test (SNOT)-22 scores, and asthma control and health-related quality life (HRQoL) outcomes in NP subgroups. Changes from baseline in fractional exhaled nitric oxide (FeNO), blood eosinophil counts, total immunoglobulin E (IgE), eosinophil-derived neurotoxin (EDN), matrix metalloproteinase-10 (MMP-10), and serum interleukin (IL)-5, IL-6, IL-8 and IL-13 were assessed (post hoc).Results: Tezepelumab reduced the AAER over 52 weeks versus placebo by 85% (95% confidence interval [CI]: 72, 92; n=118) and 51% (95% CI: 40, 60; n=941) in patients with and without NPs, respectively. At week 52, tezepelumab improved lung function, asthma control and HRQoL versus placebo in patients with and without NPs. Tezepelumab reduced SNOT-22 total scores (least-squares mean difference versus placebo [95% CI]) in patients with NPs at 28 weeks (– 12.57 points [– 19.40, – 5.73]) and 52 weeks (– 10.58 points [– 17.75, – 3.41]). At week 52, tezepelumab reduced blood eosinophil counts and FeNO, IgE, IL-5, IL-13, EDN and MMP-10 levels versus placebo, irrespective of NP status.Conclusion: Tezepelumab resulted in clinically meaningful improvements in sino-nasal symptoms and asthma outcomes in patients with severe asthma with comorbid NPs.Graphical Abstract: Plain Language Summary: Asthma is a long-term condition caused by ongoing inflammation of the lower airways. The main symptoms are difficulty breathing, coughing, wheezing and shortness of breath. Approximately 41% of patients with severe asthma also have chronic rhinosinusitis with nasal polyps, a condition that affects the upper airways and sinuses. Nasal polyps are painless soft growths inside your nose that can keep growing if not treated. Symptoms include nasal congestion with mucus, facial pain and a reduced sense of smell or taste. People with both severe asthma and nasal polyps often have severe symptoms.Thymic stromal lymphopoietin (TSLP) is a signaling molecule released by cells lining the airways in response to airborne triggers, such as smoke, pollen and viruses. TSLP activates several pathways that cause inflammation in the airways, leading to asthma symptoms. Tezepelumab is a biologic treatment that targets the very start of these inflammatory pathways by blocking TSLP.The 1-year-long clinical trial called “NAVIGATOR” reported that tezepelumab reduced asthma attacks and improved lung function and asthma symptom control compared with placebo in patients with severe asthma that was not controlled with their current medicines. This analysis of data from NAVIGATOR looked at patients with both severe asthma and nasal polyps, showing that tezepelumab treatment improved sino-nasal symptoms compared with placebo. Tezepelumab also reduced asthma attacks and improved asthma symptoms, regardless of a patient’s medical history of nasal polyps. The effects of tezepelumab in patients with severe nasal polyps are being investigated in another clinical trial called “WAYPOINT”.Keywords: chronic rhinosinusitis, nasal polyps, SNOT-22, thymic stromal lymphopoietin
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- 2023
14. Lithium carbonate-promoted mixed rare earth oxides as a generalized strategy for oxidative coupling of methane with exceptional yields
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Zhao, Kun, Gao, Yunfei, Wang, Xijun, Lis, Bar Mosevitzky, Liu, Junchen, Jin, Baitang, Smith, Jacob, Huang, Chuande, Gao, Wenpei, Wang, Xiaodong, Wang, Xin, Zheng, Anqing, Huang, Zhen, Hu, Jianli, Schömacker, Reinhard, Wachs, Israel E., and Li, Fanxing
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- 2023
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15. Incidence of Mortality and Its Predictors Among Adult Human Immune Virus Infected Patients on Antiretroviral Therapy in Wolaita Sodo University Comprehensive Specialized Hospital, Southern Ethiopia: A Retrospective Follow-Up Study
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Barata TY, Abiso G, Israel E, Molla S, and Wolka E
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mortality ,anti-retroviral therapy ,hiv/aids ,wolaita sodo town ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Tagese Yakob Barata,1 Girumneh Abiso,2 Eskinder Israel,3 Simegn Molla,4 Eskinder Wolka4 1Department of Public Health Emergency, Institute of Bele Awassaa Health Office, Wolaita, Ethiopia; 2Department of Infection Prevention and Health Promotion, Institute of Sodo Town Health Office, Wolaita, Ethiopia; 3Department of Reproductive Health, Institute of Public Health, Wolaita Sodo University, Wolaita, Ethiopia; 4Department of Epidemiology and Biostatistics, Institute of Public Health, Wolaita Sodo University, Wolaita, EthiopiaCorrespondence: Tagese Yakob Barata, Email yitagesuj@gmail.comBackground: Although the goal of ART is to have better health, extend the life of the HIV-infected patient, and decrease HIV-related death, there is a continuation of HIV-related mortality with the use of ART. This study aimed to assess the incidence of mortality and its predictors among adult HIV/AIDS patients who were on ART follow-up at Wolaita Sodo Comprehensive specialized hospital in southern Ethiopia.Methods: A retrospective follow-up study was conducted from May 1 to June 30, 2021 among adult HIV/AIDS patients with a total of 441 adult HIV/AIDS patients in this hospital included. Kaplan–Meier failure curve and Log rank test were fitted, and Cox-proportional hazards model was also used to identify the predictors of mortality. Both crude and adjusted hazard ratios (AHR) with their 95% confidence interval (CI) were calculated to show the strength of association. The proportional assumption was conducted by using a global test based on the Schoenfeld residuals.Results: Incidence of the mortality rate was 5.61 (95% CI, 4.2– 7.3) per 100 person-years observation. In the multivariable analysis, HIV/AIDS patients were widowed (aHR; 10.9 (95% CI, 3.13– 37.99), poorly drug-adhered (aHR; 5.6 (95% CI, 2.4– 13.2) and fair adhered (aHR; 3.53 (95% CI, 1.58– 7.87), WHO clinical stage IV (aHR; 5.91, (95% CI, 1.41– 24.71), history of substance use (aHR; 2.02 (95% CI, 1.01– 4.06) and history of IV drug use (aHR; 2.26 (95% CI, 1.10– 4.74) independently predicted the mortality of patients.Conclusion: In this study, incidence of mortality was relatively high. The rate of mortality may be minimized by paying particular attention to individuals with widowing, substance use at the baseline, advanced clinical stage IV, history of IV drug use at the baseline, and those with adherence problems.Keywords: mortality, anti-retroviral therapy, HIV/AIDS, Wolaita Sodo town
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- 2023
16. Progress in catalysis by mixed oxides: From confusion to catalysis science
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Wachs, Israel E.
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- 2023
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17. Metals (Cu, Ag, Au) encapsulated gallium nitride nanotubes (GaNNTs) as sensors for hexabromodiphenyl ether (HBDE) emerging organic pollutant: A computational study
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Ogungbemiro, Festus O., Louis, Hitler, Benjamin, Innocent, Okon, Gideon A., Okon, Israel E., Agwupuye, John A., and Adeyinka, Adedapo S.
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- 2023
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18. Molecular structure and catalytic promotional effect of Mn on supported Na2WO4/SiO2 catalysts for oxidative coupling of methane (OCM) reaction
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Sourav, Sagar, Kiani, Daniyal, Wang, Yixiao, Baltrusaitis, Jonas, Fushimi, Rebecca R., and Wachs, Israel E.
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- 2023
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19. The Effect of Aqueous Extract of Gum Arabic on Hepato-renal Function During Ethanol Withdrawal Induced Stress in Wistar Rats
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Jeffrey I. Omoruyi, George E. Eriyamremu, Israel E. Ebhohimen, Oke. A. Emuedo, and Edwina O. Uzunuigbe
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gum arabic ,alcohol withdrawal syndrome ,alcohol use disorder ,alcohol consumption ,dose-response ,Medical technology ,R855-855.5 - Abstract
Background: Alcohol withdrawal syndrome (AWS) is a life-threatening condition affecting alcoholics who ceased or decreased their alcohol consumption. The synthetic drugs used to manage these consequences are not without undesirable effects; hence, the need for a natural and affordable approach is raised. Objectives: This study aimed at investigating the effect of aqueous extract of gum arabic (GA) on hepato-renal functions during ethanol withdrawal syndrome in Wistar rats. Methods: In phase I, dose-response for GA and alcohol for the study were determined. In phase II, the effect of GA on biomarkers during AWS was studied. A total of 60 male Wistar rats were used for the study. Blood and tissue samples were obtained at the end of stipulated periods of oral administration for biochemical and histological analysis, and biochemical parameters were analyzed by spectrophotometry. Results: In the dose-response study, there were no significant differences (P≥0.05) in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities as well as in total bilirubin (TBIL), malondialdehyde (MDA), sodium ion (Na+), potassium ion (K+), and creatinine concentrations in groups treated with 200 mg/kg body weight (bw) and 400 mg/kg bw GA aqueous extract compared to the control group. However, significant alterations were observed in groups treated with 600 and 800 mg/kg bw GA extract. Furthermore, rats that received 5.5 mL/kg bw alcohol showed marked changes in biochemical parameters compared to the group that received 4.5 mL/kg bw and the control group. The results obtained in Phase II exhibited the hepato-renal protective effect of GA during ethanol withdrawal. Statistical analysis of the obtained results indicated a better response from the study groups that were pre-treated or co-administered with GA compared to the group that was post-treated. Conclusion: The result of this study suggests that GA aqueous extract offered better protection prophylactically than curatively.
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- 2022
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20. Suboptimal Control of Asthma Among Diverse Patients: A US Mixed Methods Focus Group Study
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George M, Balantac Z, Gillette C, Farooqui N, Tervonen T, Thomas C, Gilbert I, Gandhi H, and Israel E
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chronic obstructive pulmonary disease ,qualitative ,inhaler ,maintenance therapy ,rescue therapy ,corticosteroid ,asthma management ,asthma control ,shared decision-making ,asthma control test ,act ,asthma impairment and risk questionnaire ,airq ,adult asthma adherence questionnaire ,aaaq ,treatment satisfaction questionnaire for medication ,tsqm ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Maureen George,1 Zaneta Balantac,2 Chris Gillette,3 Nabeel Farooqui,4 Tommi Tervonen,5 Caitlin Thomas,5 Ileen Gilbert,6 Hitesh Gandhi,6 Elliot Israel7 1School of Nursing, Columbia University, New York, NY, USA; 2Patient-Centered Research, Evidera, San Francisco, CA, USA; 3Department of Physician Assistant Studies, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Allergy Partners, Fishers, IN, USA; 5Patient-Centered Research, Evidera, London, UK; 6Medical Affairs-Respiratory, AstraZeneca, Wilmington, DE, USA; 7Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USACorrespondence: Maureen George, School of Nursing at CUIMC, Columbia University School of Nursing, 630 West 168th Street Mail Code 6, New York, NY, 10032, USA, Tel +1 212-305-1175 ; Tel +1 212-305-1175, Email mg3656@cumc.columbia.eduPurpose: The US National Asthma Education and Prevention Program updates and Global Initiative for Asthma report encourage considering the patient perspective to improve asthma control. The objective of the present study was to collect data about the perceptions, experiences, and concerns of adult patients and caregivers of children with asthma regarding rescue, maintenance, and oral corticosteroid treatments.Patients and Methods: In-person focus groups were conducted in three cities across the US. Participants also completed patient-reported outcome measures assessing asthma control and experiences.Results: Focus groups were conducted in demographically and clinically diverse adults with asthma (five groups, n=34), caregivers of children with asthma (five groups, n=35), and adults with a dual diagnosis of asthma and chronic obstructive pulmonary disease (one group, n=5). Only 28% of patients were well-controlled by Asthma Control Test/Asthma Control Test-Caregiver Report and 18% by Asthma Impairment and Risk Questionnaire. Forty-four percent of participants reported not following their prescribed medical plan. Four key themes emerged from the focus groups: (1) asthma symptom control and monitoring are often inadequate; (2) treatments are often used incorrectly; (3) communication between health care professionals and patients or caregivers is often ineffective; and (4) concerns related to treatment and desires to improve treatment.Conclusion: Control of asthma symptoms is suboptimal in the vast majority of patients and both patients and caregivers do not feel sufficiently informed about asthma. Health care providers should be encouraged to engage patients and caregivers in shared decision making for managing asthma and selecting treatments that integrate patient values, preferences, and lifestyles.Keywords: chronic obstructive pulmonary disease, qualitative, inhaler, maintenance therapy, rescue therapy, corticosteroid, asthma management, asthma control, shared decision-making, Asthma Control Test, ACT, Asthma Impairment and Risk Questionnaire, AIRQ, Adult Asthma Adherence Questionnaire, AAAQ, Treatment Satisfaction Questionnaire for Medication, TSQM
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- 2022
21. Metals (Cu, Ag, Au) encapsulated gallium nitride nanotubes (GaNNTs) as sensors for hexabromodiphenyl ether (HBDE) emerging organic pollutant: A computational study
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Festus O. Ogungbemiro, Hitler Louis, Innocent Benjamin, Gideon A. Okon, Israel E. Okon, John A. Agwupuye, and Adedapo S. Adeyinka
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Sensor ,HBDE ,Adsorption ,DFT ,GaNNT ,Chemistry ,QD1-999 - Abstract
This study is aimed at investigating the potential of transition metals (Cu, Ag, Au) doped gallium nitride nanotubes (GaNNTs) as sensor materials for the enhanced detection of hexabromodiphenyl ether (HBDE) an emerging organic pollutant that has been linked to several health problems, including developmental and neurological disorders, hormonal imbalances, and cancer. Using the density functional theory (DFT) method at the B3LYP-D3(BJ)/def2SVP level of theory, the potential of pristine and metal (Ag, Au, and Cu) doped gallium nitride (GaNNT) nanotube to sense and detect HBDE was evaluated. The interaction of HBDE on the surface was evaluated at two sites, the bromine (Br) and oxygen (O) sites to evaluate the best conformation adsorption. The results showed that the Br site was the preferred sites of adsorption with binding energies of −43.926 kcal/mol, −43.926 kcal/mol, −43.926 kcal/mol and −31.376 kcal/mol for HBDE_Br_Ag@GaNNT, HBDE_Br_Au@GaNNT, HBDE_Br_Cu@GaNNT and HBDE_Br_@GaNNT respectively. The mechanism of surface adsorption was found to be chemisorption and doping of GaNNT surface with metals was found to enhance the conductivity and sensitivity of the surface towards the adsorbent. The result of the thermodynamic assay also affirmed the spontaneous and favorable nature of the surface and adsorbent. Overall, the various analysis considered so far, points that pristine and metal functionalized GaNNT could be used as potential materials to sense HBDE.
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- 2023
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22. Controlling the Reconstruction of Ni/CeO2 Catalyst during Reduction for Enhanced CO Methanation
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Xinyu Cao, Tiancheng Pu, Bar Mosevitzky Lis, Israel E. Wachs, Chong Peng, Minghui Zhu, and Yongkang Hu
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Nickel–ceria catalyst ,Catalyst activation ,Crystallinity ,Methanation ,In situ spectroscopy ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Reductive pretreatment is an important step for activating supported metal catalysts but has received little attention. In this study, reconstruction of the supported nickel catalyst was found to be sensitive to pretreatment conditions. In contrast to the traditional activation procedure in hydrogen, activating the catalyst in syngas created supported Ni nanoparticles with a polycrystalline structure containing an abundance of grain boundaries. The unique post-activation catalyst structure offered enhanced CO adsorption and an improved CO methanation rate. The current strategy to tune the catalyst structure via manipulating the activation conditions can potentially guide the rational design of other supported metal catalysts.
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- 2022
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23. Dependency of CO2 methanation on the strong metal-support interaction for supported Ni/CeO2 catalysts
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Pu, Tiancheng, Chen, Jiacheng, Tu, Weifeng, Xu, Jing, Han, Yi-Fan, Wachs, Israel E., and Zhu, Minghui
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- 2022
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24. Controlling the Reconstruction of Ni/CeO2 Catalyst during Reduction for Enhanced CO Methanation
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Cao, Xinyu, Pu, Tiancheng, Lis, Bar Mosevitzky, Wachs, Israel E., Peng, Chong, Zhu, Minghui, and Hu, Yongkang
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- 2022
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25. Efficacy and Safety of Masitinib in Corticosteroid-Dependent Severe Asthma: A Randomized Placebo-Controlled Trial
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Davidescu L, Ursol G, Korzh O, Deshmukh V, Kuryk L, Nortje MM, Godlevska O, Devouassoux G, Khodosh E, Israel E, Moussy A, Mansfield CD, Hermine O, and Chanez P
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asthma clinical trials ,asthma medication ,mast cells ,tyrosine kinases ,severe asthma ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Lavinia Davidescu,1 Grigoriy Ursol,2 Oleksii Korzh,3 Vikranth Deshmukh,4 Lesia Kuryk,5 Monja-Marie Nortje,6 Olga Godlevska,3 Gilles Devouassoux,7 Eduard Khodosh,8 Elliot Israel,9,10 Alain Moussy,11 Colin D Mansfield,11 Olivier Hermine,11– 13 Pascal Chanez14 1Department of Pulmonology, University of Oradea, Oradea, Romania; 2Medical and Diagnostic Center of Private Enterprise of Private Production Company “Acinus”, Kropyvnytskyi, Ukraine; 3Department of General Practice - Family Medicine, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine; 4Department of Pulmonary Medicine, Respira Hospital, Nagpur, Maharashtra, India; 5National Institute of Phthisiology and Pulmonology Named After F.G. Yanovsky of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; 6Moriana Clinical Research, Brandfort, South Africa; 7Department of Pulmonology, Hôpital de la Croix Rousse, GHN, HCL and Université Claude Bernard Lyon 1, Lyon, France; 8Department of Pulmonology, Municipal Nonprofit Enterprise, City Clinical Hospital #13, Kharkiv, Ukraine; 9Harvard Medical School, Boston, MA, USA; 10Division of Pulmonary and Critical Care Medicine and Allergy and Immunology, Brigham and Women’s Hospital, Boston, MA, USA; 11AB Science, Paris, France; 12Imagine Institute, INSERM UMR 1163 and CNRS ERL 8254, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implication, Hôpital Necker, Paris, France; 13Université Paris Descartes, Sorbonne Paris Cité, Paris, France; 14Clinique des Bronches, Allergie et Sommeil, APHM Hôpital Nord, C2VN Center INSERM INRAE UMR1062, Aix-Marseille Université, Marseille, FranceCorrespondence: Pascal Chanez, Clinique des Bronches, Allergie et Sommeil, APHM Hôpital Nord, C2VN Center INSERM INRAE UMR1062, Aix-Marseille Université, Marseille, France, Tel +33 6 50 71 07 05, Email Pascal.CHANEZ@univ-amu.frBackground: Masitinib is an oral tyrosine kinase inhibitor that selectively targets mast cell activity and platelet-derived growth factor receptor (PDGFR) signaling, both of which are implicated in various mechanisms of asthma pathogenesis.Objective: Assessment of masitinib as an add-on to standard maintenance therapy as compared with placebo in the treatment of oral corticosteroid-dependent severe asthma.Methods: We conducted a randomized (2:1), placebo-controlled study of masitinib (6 mg/kg/d) in adults with severe asthma uncontrolled by high dose inhaled corticosteroids and long-acting beta-adrenoreceptor agonists plus oral corticosteroids (OCS) (≥ 7.5 mg/d). No minimum baseline blood eosinophil count was specified. Following a protocol amendment, the primary endpoint was reduction of annualized severe asthma exacerbation rate adjusted for the overall time on treatment (SAER). Subgroup analysis according to yearly cumulative OCS intake was also performed, a higher OCS dose indicating more severe asthma that is harder to control.Results: Following an average exposure of approximately 13 months, masitinib (n = 240) reduced the SAER by 35% relative to placebo (n = 115) (rate ratio (RR) 0.65 (95% CI [0.47– 0.90]; P = 0.010)). For patients with eosinophil ≥ 150 cell/μL, masitinib (n = 181) reduced SAER by 38% relative to placebo (n = 87); RR 0.62 (95% CI [0.42– 0.91]; P = 0.016). Benefit of masitinib was shown to increase in the most severely affected patients (OCS intake of > 1000 mg/year), with a significant (P < 0.01) reduction in SAER of 50%– 70%. Safety was consistent with the known masitinib profile.Conclusion: Orally administered masitinib reduces the risk of asthma exacerbations in severe asthma patients, with an acceptable safety profile. Masitinib may potentially provide a new treatment option for oral corticosteroid-dependent severe asthma.Keywords: asthma clinical trials, asthma medication, mast cells, tyrosine kinases, severe asthma
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- 2022
26. Effect of redox promoters (CeOx and CuOx) and surface sulfates on the selective catalytic reduction (SCR) of NO with NH3 by supported V2O5-WO3/TiO2 catalysts
- Author
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Guo, Mingyu, Mosevitzky Lis, Bar, Ford, Michael E., and Wachs, Israel E.
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- 2022
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27. The effect of non-redox promoters (AlOx, POx, SiOx and ZrOx) and surface sulfates on supported V2O5-WO3/TiO2 catalysts in selective catalytic reduction of NO with NH3
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Guo, Mingyu, Mosevitzky Lis, Bar, Ford, Michael E., and Wachs, Israel E.
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- 2022
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28. Elusive supported surface M2Ox dimer active site (M = Re, W, Mo, Cr, V, Nb, and Ta).
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Wachs, Israel E.
- Subjects
EXTENDED X-ray absorption fine structure ,TRANSITION metal catalysts ,HETEROGENEOUS catalysis ,HETEROGENEOUS catalysts ,MOLECULAR structure - Abstract
Supported transition metal oxide catalysts are extensively used as heterogeneous catalysts for various energy, chemical, and environmental applications. The molecular structures of dehydrated surface metal oxide phases are crucial for understanding structure-activity/selectivity relationships that guide the design of enhanced catalysts. Some early studies suggested that dimeric (aka binuclear) surface metal oxide sites were more active/selective than monomeric (aka mononuclear) sites, prompting interest in synthesizing catalysts with supported dimeric metal oxide structures. This review examines the literature on dehydrated silica-based supported group 7-5 MO
x catalysts (ReOx , WOx , MoOx , CrOx , VOx , NbOx , and TaOx on SiO2 , MCM-41, AlOx /SiO2 , and H-ZSM-5) for their surface metal oxide structures. In situ Raman, extended x-ray absorption fine structure, and ultraviolet-visible spectroscopy indicate that monomeric surface MOx structures predominate in all such catalysts. Therefore, the cursory use of dimeric surface M2 Ox sites in catalytic mechanisms and reaction models in heterogeneous catalysis by supported metal oxides is questionable, and moving forward, the invoking of supporting dimeric surface M2 Ox sites should be critically examined and backed up with direct spectroscopic methods. [ABSTRACT FROM AUTHOR]- Published
- 2024
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29. Practical Considerations for Understanding Surface Reaction Mechanisms Involved in Heterogeneous Catalysis.
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Kiani, Daniyal and Wachs, Israel E.
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- 2024
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30. A Study of Free Surface Agitation in a Shipyard Using Numerical Modeling.
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Herrera, Israel E., Galván, Arturo, Moreno-Martínez, Jatziri Y., and Gamiño, Edith A.
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FREE surfaces ,EXTREME value theory ,NULL hypothesis ,SHIPYARDS ,STATISTICS - Abstract
In recent years, the Port of Topolobampo, Sinaloa, Mexico, has experienced unusual free sea surface elevations, particularly during the months of November and December, affecting the shipyard areas, service docks, and berthing locations. This study focuses on analyzing the oscillatory behavior of free surface elevations in shipyard regions. A hydrodynamic model was employed to simulate the circulation and sea surface agitation, aiming to quantify the elevation magnitudes based on oceanographic and meteorological data from November of the preceding year. A 30-day numerical simulation was conducted, revealing the velocity fields associated with coastal currents and tides during November, as well as the interaction between incident waves and wave transformations due to protective structures. The results demonstrated accurate behavior in 95% of the simulation period, while anomalous elevations exceeding those specified in the design and operational guidelines of the Port of Topolobampo were observed during the final five days of the simulation. An ANOVA test was performed between the surface elevation and vertically integrated velocity to assess whether the deviations in the last five days were statistically significant compared to the rest of the simulation period. With a P-value of less than 0.05, the null hypothesis of no difference was rejected, confirming a significant variation. These findings suggest that the extreme values recorded should be considered for the potential redesign of shipyard infrastructure. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Number of surface sites and turnover frequencies for oxide catalysts
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Wachs, Israel E.
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- 2022
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32. Induced activation of the commercial Cu/ZnO/Al2O3 catalyst for the steam reforming of methanol
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Li, Didi, Xu, Fang, Tang, Xuan, Dai, Sheng, Pu, Tiancheng, Liu, Xianglin, Tian, Pengfei, Xuan, Fuzhen, Xu, Zhi, Wachs, Israel E., and Zhu, Minghui
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- 2022
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33. Redox Dynamics of Active VOx Sites Promoted by TiOx during Oxidative Dehydrogenation of Ethanol Detected by Operando Quick XAS
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Anna Zabilska, Adam H. Clark, Benjamin M. Moskowitz, Israel E. Wachs, Yuya Kakiuchi, Christophe Copéret, Maarten Nachtegaal, Oliver Kröcher, and Olga V. Safonova
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Chemistry ,QD1-999 - Published
- 2022
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34. Central Obesity and Associated Factors Among Urban Adults in Dire Dawa Administrative City, Eastern Ethiopia
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Israel E, Hassen K, Markos M, Wolde K, and Hawulte B
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central obesity ,prevalence ,associated factors ,eastern ethiopia ,Specialties of internal medicine ,RC581-951 - Abstract
Ephrem Israel,1 Kalkidan Hassen,2 Melese Markos,3 Kiber Wolde,4 Bahailu Hawulte5 1Dire Dawa Regional Health Bureau, Dire Dawa City Administration, Dire Dawa, Ethiopia; 2Department of Population and Family Health, Institute of Health Science, Jimma University, Jimma, Ethiopia; 3Department of Public Health, College of Health and Medical Science, Wachemo University Durame Campus, Durame, Ethiopia; 4Department of Public Health, College of Medicine and Health Science, Dire Dawa University, Dire Dawa, Ethiopia; 5School of Public Health, College of Medicine and Health Science, Haramaya University, Harar, EthiopiaCorrespondence: Ephrem Israel, Dire Dawa Regional Health Bureau, Dire Dawa City Administration, P. O. Box 1377, Dire Dawa, Ethiopia, Tel +251 913285488, Email ephremisrael2008@gmail.comBackground: Central obesity (CO) is a medical problem in which extra fat is accumulated in the abdomen and stomach extent that it may harm health. Furthermore, previous studies in Ethiopia predominantly relied on body mass index used to measure obesity and do not show distribution of fat. However, there is a paucity of information on the measurement of central obesity using waist circumference and associated factors in Ethiopia particularly in the study area. Hence, the purpose of this study is to assess the prevalence of central obesity and associated factors among urban adults in Dire Dawa, administrative city, Eastern Ethiopia.Methods: A community-based cross-sectional study was conducted among 633 adults in selected kebeles of administrative city from October 15 to November 15, 2020. A multistage and systematic sampling procedure was used to select study participants. Central obesity is defined as a condition with waist circumference ≥ 83.7 cm for men and ≥ 78 cm for women with or without general obesity (GO). Odds ratio along with 95% confidence interval was estimated to identify factors associated with central obesity using multiple logistic regression analysis.Results: The overall prevalence of central obesity was 76.1%; at 95% CI (73%, 80%). Associated factors of central obesity were age 45 years and above [AOR = 3.75, 95% CI (1.86, 7.55)], being female [AOR = 2.52, 95% CI: (1.62, 3.94)], alcohol consumption [AOR = 2.61, 95% CI: (1.69, 4.05], physical inactivity [AOR = 2.05, 95% CI: (1.23, 3.42)], and two hour and more time spent on watching television [AOR = 3.30, 95% CI: (1.59, 6.82)].Conclusion: The study shows central obesity was high in the study area. Age 45 years and above, being females, married, physically inactive, alcohol consumption, and spending a long time watching television was associated with central obesity. Having regular physical activity, limiting alcohol drinking, and limiting time spent watching television were recommended to prevent central obesity and associated risk among adults.Keywords: central obesity, prevalence, associated factors, Eastern Ethiopia
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- 2022
35. Congenital Zika syndrome
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Israel E. Crisanto-López, Pablo López-De Jesús, Jacqueline López-Quecho, and Juan C. Flores-Alonso
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Zika virus. Congenital Zika syndrome. Microcephaly. ,Pediatrics ,RJ1-570 ,Public aspects of medicine ,RA1-1270 - Abstract
In February 2016, the World Health Organization declared Zika virus (ZIKV) infection a public health emergency of international concern because it caused congenital Zika syndrome (CZS). The CZS is considered a specific pattern of birth defects caused by ZIKV infection, which is transmitted by the bite of the Aedes aegypti mosquito. The CZS clinical manifestations are broad and nonspecific, including microcephaly, subcortical calcifications, ocular alterations, congenital contractures, early hypertonia, and pyramidal as well as extrapyramidal symptoms. The ZIKV has gained great importance because it has affected a large percentage of the population worldwide during the last few years, despite the measures implemented by international organizations. The pathophysiology and non-vectorial transmission routes of the virus are still under study. The diagnosis is made upon suspicion of ZIKV infection, the patient’s clinical manifestations, and it is confirmed by molecular laboratory tests demonstrating the presence of viral particles. Unfortunately, there is no specific treatment or vaccine for this condition; however, patients receive multidisciplinary care and constant monitoring. Therefore, the strategies that have been implemented are directed toward preventive measures and vector control.
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- 2023
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36. Numerical Modelling of Free Surface Agitation in a Coastal Lagoon by Roadway Path Influence
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Israel E. Herrera, Franklin M. Torres, Jatziri Y. Moreno, José M. Gutierrez, and Noé Saldaña
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Electronic computers. Computer science ,QA75.5-76.95 - Abstract
The development and construction of highway infrastructure are essential in developing countries, whereas its layout and construction sometimes interact with the coastal environment. One problem to attend to is that the outline and geometry designs impact as little as possible on the hydrodynamic circulation of coastal bodies in order to alter the associated ecosystem as little as possible. The study area is located in the north of Colombia, and is made up of a continental coastal zone (Mallorquín Lagoon) and a marine zone (Caribbean Sea), in which a highway is projected that provides communication between two locations. This study presents the application of a numerical model previously developed and modified by the Berkhoff equation, which is developed in a finite difference scheme and has been validated and applied in different works in coastal and fluvial shallow water areas. The application of the model was carried out in a hydrodynamic circulation research project for a one-way highway through a coastal lagoon, where the knowledge of the magnitude of the incident wave height in the structure of the road body is necessary for the design, protection elements, and road geometry. Two numerical simulation scenarios were carried out, specifying normal conditions and extraordinary wave conditions in the month of November with a simulation time of 15 days, obtaining the velocity field associated with coastal currents, waves, and wave modification phenomena, such as refraction, diffraction, and reflection, which provide the height of the incident wave on the highway and the recirculation patterns in the coastal lagoon to identify alterations in the ecosystem. The results of the wave height in each scenario and the velocity field provide values to be used in the design, type of armor, and dimensions of the protection works required for the proper functioning of the road structure.
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- 2023
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37. Noise modelling and mitigation for broadband in‐door power line communication systems
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Adegoke, Ogunlade M., primary, Gbadamosi, Saheed Lekan, additional, Adejumobi, Babatunde S., additional, Owolabi, Israel E., additional, Oke, Wasiu Adeyemi, additional, and Nwulu, Nnamdi I., additional
- Published
- 2024
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38. Defining Structure-function Consequences of T2 Inflammation in Asthma by qCT Machine Learning in the Severe Asthma Research Program (SARP3)
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Boomer, J.S., primary, Choi, J., additional, Lee, D., additional, Christenson, S.A., additional, Huang, B., additional, Hall, C., additional, Leung, C., additional, Lin, C.-L., additional, Hoffman, E.A., additional, Fain, S.B., additional, Elicker, B., additional, Henry, T., additional, Nagle, S.K., additional, Schiebler, M., additional, Newell, J.D., additional, Krings, J.G., additional, Denlinger, L.C., additional, Israel, E., additional, Jarjour, N.N., additional, Levy, B.D., additional, Mauger, D., additional, Wenzel, S.E., additional, Hastie, A.T., additional, Woodruff, P., additional, Fahy, J.V., additional, and Castro, M., additional
- Published
- 2024
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39. Patient Experiences During Acute Exacerbation of Asthma: Survey Results
- Author
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Gardner, D.D., primary, Castro, M., additional, Israel, E., additional, Williams, D., additional, Quintero, A., additional, Gokani, R., additional, and Hey-Hadavi, J., additional
- Published
- 2024
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40. Thickening of the Basement Membrane Zone in Asthma Is Associated With Type 2 Inflammation and Increased Bronchomotor Tone
- Author
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Leung, C., primary, Finkbeiner, W., additional, Charbit, A.R., additional, Israel, E., additional, Levy, B.D., additional, Denlinger, L.C., additional, Jarjour, N.N., additional, Wenzel, S.E., additional, Sumino, K., additional, Castro, M., additional, Erzurum, S.C., additional, Moore, W.C., additional, Hastie, A., additional, Mauger, D.T., additional, Hoffman, E.A., additional, Andersen, J.B., additional, Woodruff, P., additional, and Fahy, J.V., additional
- Published
- 2024
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41. Proximal Mucus Plug Formation Is Associated With Downstream Air Trapping in Severe Asthma
- Author
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Peterson, S., primary, Newell, J.D., additional, Hague, C.J., additional, Blanke, P., additional, Eddy, R.L., additional, Datta, K., additional, Fahy, J.V., additional, Choi, J., additional, Wenzel, S.E., additional, Israel, E., additional, Levy, B.D., additional, Mauger, D.T., additional, Fain, S.B., additional, Jarjour, N.N., additional, Denlinger, L.C., additional, Hoffman, E.A., additional, and Castro, M., additional
- Published
- 2024
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42. High Airway TSLP Levels in Asthma Associate With More Severe Disease and Multiple Biomarkers of Type 2 Inflammation
- Author
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Khanna, K., primary, Tang, M., additional, Jackson, N., additional, Charbit, A.R., additional, Bleecker, E.R., additional, Castro, M., additional, Comhair, S.A.A., additional, Denlinger, L.C., additional, Erzurum, S.C., additional, Hastie, A.T., additional, Moore, W.C., additional, Israel, E., additional, Levy, B.D., additional, Jarjour, N.N., additional, Johansson, M.W., additional, Mauger, D., additional, Phillips, B.R., additional, Sumino, K., additional, Wenzel, S.E., additional, Woodruff, P., additional, Seibold, M.A., additional, and Fahy, J.V., additional
- Published
- 2024
- Full Text
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43. Wind Vulnerability of Flexible Outdoor Single-Post Billboards
- Author
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Rolando Salgado-Estrada, Arturo Galván, Jatziri Y. Moreno-Martínez, Ernesto A. Elvira-Hernández, Franco Carpio, Agustín L. Herrera-May, Sergio A. Zamora Castro, and Israel E. Herrera-Díaz
- Subjects
flexible single-post billboards ,wind engineering ,wind loads ,reliability analysis ,CFD ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Increased temperature due to global climate change is increasing the magnitude and frequency of extreme winds making billboard structures more vulnerable. This paper proposes a methodology to determine the structural safety of flexible outdoor single-post billboards. A CFD model of a flexible single-post billboard was performed as an example. Resultant wind forces were obtained for the previous model using different wind speeds. A mechanical numerical model of the billboard was realized, and this was subjected to the resultant wind forces. Internal forces for the most vulnerable places of the billboard were obtained for all different adopted wind speeds. Next, a reliability analysis of the billboard was performed considering several values for the bias factor and coefficient of variation for the internal forces caused by wind. Safety levels determined from the reliability analysis indicate that a billboard designed with a nominal wind speed of 180 km/h cannot achieve the target probability index of 3.2 for wind speed higher or equal to 200 km/h for any of the adopted probabilistic parameters. Significant differences in the found safety levels for the evaluated probability parameters indicate that billboard structures could undergo safety values below the target one with changes in the case where wind characteristics endanger this type of structure.
- Published
- 2023
- Full Text
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44. Oxygen‐Assisted Supercapacitive Swing Adsorption of Carbon Dioxide.
- Author
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Bilal, Muhammad, Li, Jiajie, Kumar, Neelesh, Mosevitzky, Bar, Wachs, Israel E., and Landskron, Kai
- Subjects
CARBON dioxide adsorption ,CARBON sequestration ,GAS mixtures ,OXYGEN electrodes ,ELECTRODE performance ,AQUEOUS electrolytes - Abstract
We report on the supercapacitive swing adsorption (SSA) of carbon dioxide at different voltage windows in the presence of oxygen using activated carbon electrodes, and deliquescent, aqueous electrolytes. The presence of O2 in the CO2/N2 gas mixture results in an up to 11 times higher CO2 adsorption capacity with 3 M MgBr2 (at 0.6 V) and up to 4–5 times higher adsorption capacity with 3 M MgCl2 (at 1 V). A tradeoff between high CO2 adsorption capacities and lower coulombic efficiencies was observed at voltages above 0.6 V. The energetic and adsorptive performance of the electrodes in the presence of oxygen below 0.5 V was similar to the performance with a CO2/N2 mixture without oxygen at 1 V. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) of the electrodes demonstrate that the specific capacitance increases while the diffusion resistance decreases in the presence of oxygen. Oxygen concentrations ranging between 5–20 % give similar energetic and adsorptive performance. The electrodes exhibit stable performance for up to 100 cycles of operation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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45. Synergistic Cooperation of Dual-Phase Redox Catalysts in Chemical Looping Oxidative Coupling of Methane.
- Author
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Brody, Leo, Mosevitzky Lis, Bar, Pérez Ortiz, Abigail, Kosari, Mohammadreza, Vogt-Lowell, Kyle, Portillo, Sam, Schomäcker, Reinhard, Wachs, Israel E., and Li, Fanxing
- Published
- 2024
- Full Text
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46. Comparison of SiO2-supported molybdena, tungsta and rhenia catalysts for olefin metathesis.
- Author
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Zhang, Bin and Wachs, Israel E.
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- 2024
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47. The Conundrum of "Pair Sites" in Langmuir–Hinshelwood Reaction Kinetics in Heterogeneous Catalysis.
- Author
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Kiani, Daniyal and Wachs, Israel E.
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- 2024
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48. Case report on activated PI3K-delta syndrome.
- Author
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Crisanto-López, Israel E., Pérez-Arzola, Alan A., Hernández-Castañeda, Yazmin, Carrasco-Trinidad, Reyna G., Vera-Loaiza, Aurea, Jiménez-Pérez, Berenice, Guzmán-Santiago, Tania A., Rodríguez-Hurtado, Pablo O., Salazar-Bonilla, Wilbert, and Juárez-Melchor, Daniela
- Subjects
- *
PHOSPHATIDYLINOSITOL 3-kinases , *POLYCYSTIC kidney disease , *BRONCHIECTASIS , *AVALANCHE photodiodes , *LEUCOPENIA - Abstract
Background: Activated phosphoinositide 3-kinase delta syndrome (APDS) [OMIM 615513] is an inborn error of immunity with autosomal dominant inheritance caused by a pathogenic variant in the PIK3CD gene. The prevalence ratio of APDS is < 1: 1,000,000 newborns. The main clinical features of APDS are sinopulmonary infections, benign lymphoproliferation, autoinflammatory disease, and a major risk of lymphoid neoplasms. Clinical case: A 17-year-old female with a history of pneumonia at 9 months of age subsequently developed recurrent respiratory tract infections, bronchiectasis, perforated otitis media, unilateral tonsillar lymphoid hyperplasia, pansinusitis, recurrent oral candidiasis, and chronic rhinitis. Laboratory studies reported persistent leukopenia and lymphopenia, low CD4 lymphocyte subpopulation, and persistently elevated immunoglobulin M immunoglobulin studies with values up to 692 mg/dL. An inborn error of immunity next-generation sequencing and multiplex ligation-dependent probe amplification analysis detected a heterozygous pathogenic variant in the PIK3CD gene, compatible with APDS. Treatment with monthly injectable gamma globulin and prophylactic antibiotics was started, allowing better control of the infectious processes. Conclusion: This is the second case of APDS reported in Mexico in the literature. It is important to be aware of this condition to make a timely diagnosis, which requires a high clinical suspicion and immunological and genetic studies to provide adequate treatment and prevent complications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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49. Probing the surface of promoted CuO-Cr2O3-Fe2O3 catalysts during CO2 activation
- Author
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Zhu, Minghui, Chen, Jiacheng, Shen, Liang, Ford, Michael E., Gao, Jian, Xu, Jing, Wachs, Israel E., and Han, Yi-Fan
- Published
- 2020
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50. Optimal Pharmacological Treatment In Patients With Heart Failure. Analysis Of The Colombian Heart Failure Registry (RECOLFACA)
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Gomez-Mesa, Juan, primary, Marín, Israel E., additional, Soria, Israel O. Marín, additional, de Leon, Juán D. López Ponce, additional, Escalante, Manuela, additional, Giraldo, Clara I. Saldarriaga, additional, Echeverria, Luis E., additional, Toquica, Alex Rivera, additional, Luna, Paula, additional, Quintero, Sebastian Campbell, additional, Rodríguez, Lisbeth N. Morales, additional, Silgado, Gustavo Moreno, additional, Palau, Ricardo Gómez, additional, Madariaga, Juan C. Ortega, additional, Estupiñan, Juan F. Carvajal, additional, and Yepes, Viviana Quintero, additional
- Published
- 2024
- Full Text
- View/download PDF
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