253 results on '"Ismaili, Lhassane"'
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2. Efficient Two-Step Synthesis of Novel Pyrimido[4,5- d ] Pyrimidines with Potent Neuroprotective, Antioxidant, and A β Anti-Aggregation Properties.
3. Synthesis and Biological Evaluation of New Benzochromenopyrimidines for the Therapy of Colon and Lung Cancer
4. Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties
5. Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy
6. Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties
7. Synthesis, characterization, theoretical studies, ADMET and drug-Likeness analysis: Electrochemical and biological activities of metal complexes of 3-(2-hydroxybenzoyl)-2H-chromen-2-one
8. Design, Synthesis, in Silico and Biological Evaluation of Novel 4‐Aminopyrimidine‐5‐carbonitriles
9. The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy
10. Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
11. Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy
12. Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties.
13. New highly fluorescent hybrids (benz)imidazol-2-aminonicotinonitrile and -2-aminoisophthalonitrile: synthesis, characterization, fluorescence study, and theoretical calculations
14. The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy
15. Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
16. Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
17. Calcium channel blockers’ contribution to overcoming Current drug discovery challenges in Alzheimer’s disease
18. Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
19. Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties
20. Multicomponent reactions as a privileged tool for multitarget-directed ligand strategies in Alzheimer’s disease therapy
21. Editorial: Advances in drug discovery for anti-Alzheimer’s agents
22. Quinolone–benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer Disease
23. Multitarget-Directed Antioxidants as Therapeutic Agents
24. List of Contributors
25. Synthesis, regioselectivity, and DFT analysis of new antioxidant pyrazolo[4,3-c]quinoline-3,4-diones
26. Latest progress in the development of multitarget ligands for Alzheimer's disease based on the Hantzsch reaction
27. Ferulic acid derivatives block coronaviruses HCoV-229E and SARS-CoV-2 replication in vitro. (C. Van Lint and G.Herbein are co-senior authors, equal contribution)
28. Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists
29. Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia
30. Synthesis and biological assessment of new pyrimidopyrimidines as inhibitors of breast cancer resistance protein (ABCG2)
31. Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.
32. Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy
33. Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power
34. Donepezil–ferulic acid hybrids as anti-Alzheimer drugs
35. Synthesis and Fluorescence of (E)‐3‐Aryl‐2‐(5‐aryl‐4H‐1,2,4‐triazol‐3‐yl) Acrylonitriles
36. Transition-metal complexes of N,N′-di(4-bromophenyl)-4-hydroxycoumarin-3-carboximidamide: synthesis, characterization, biological activities, ADMET and drug-likeness analysis
37. Synthesis and antioxidant activity evaluation of new hexahydropyrimido[5,4- c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4- c]quinoline-5-ones obtained by Biginelli reaction in two steps
38. (±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer’s Disease
39. Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5‐a]pyridine Derivatives
40. Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy
41. 5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease
42. Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments
43. Molecular lipophilicity determination of a huperzine series by HPLC: Comparison of C18 and IAM stationary phases
44. Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives
45. Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy
46. Automated Synthesis of New Quinoxalinetacrines
47. Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy
48. Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels
49. Chromenones as Multineurotargeting Inhibitors of Human Enzymes
50. Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction
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