Search

Your search keyword '"Isla-Tejera, Beatriz"' showing total 39 results
Start Over Author "Isla-Tejera, Beatriz"
39 results on '"Isla-Tejera, Beatriz"'

6. Efficacy and safety of anakinra and canakinumab in PSTPIP1-associated inflammatory diseases: a comprehensive scoping review.

Author

Luis Sanz-Cabanillas, Juan, Gómez-García, Francisco, Jesús Gómez-Arias, Pedro, Montilla-López, Ana, Gay-Mimbrera, Jesús, Ruano, Juan, Isla-Tejera, Beatriz, and Parra-Peralbo, Esmeralda

Subjects
ANAKINRA, INTERLEUKIN-1, PYODERMA gangrenosum, GENETIC mutation, WORLD health
Abstract

Introduction: This scoping review explores the effectiveness of IL-1 pathway inhibitors in managing PSTPIP1-associated inflammatory diseases (PAID). These diseases are marked by abnormal IL-1 pathway activation due to genetic mutations. Methods: Our methodology adhered to a pre-published protocol and involved a thorough search of MEDLINE and EMBASE databases up to February 2022, following the Joanna Briggs Institute Reviewer's Manual and the PRISMA Extension for Scoping Reviews. The review included studies reporting on IL-1 pathway inhibitor use in PAID patients. Results: From an initial pool of 5,225 articles, 36 studies involving 43 patients were selected. The studies predominantly used observational designs and exhibited diversity in patient demographics, treatment approaches, and outcomes. Anakinra and canakinumab demonstrated promise in treating sterile pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) and PSTPIP1-associated myeloidrelated-proteinemia inflammatory (PAMI) syndromes, with scant data on other syndromes. Notably, there was a paucity of information on the adverse effects of these treatments, necessitating cautious interpretation of their safety profile. Conclusion: Current evidence on IL-1 pathway inhibitors for PAID is primarily from observational studies and remains limited. Rigorous research with larger patient cohorts is imperative for more definitive conclusions. Collaborative efforts among specialized research centers and international health initiatives are key to advancing this field. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Evaluating characteristics of PROSPERO records as predictors of eventual publication of non-Cochrane systematic reviews: a meta-epidemiological study protocol

Author

Ruano, Juan, Gómez-García, Francisco, Gay-Mimbrera, Jesús, Aguilar-Luque, Macarena, Fernández-Rueda, José Luis, Fernández-Chaichio, Jesús, Alcalde-Mellado, Patricia, Carmona-Fernandez, Pedro J., Sanz-Cabanillas, Juan Luis, Viguera-Guerra, Isabel, Franco-García, Francisco, Cárdenas-Aranzana, Manuel, Romero, José Luis Hernández, Gonzalez-Padilla, Marcelino, Isla-Tejera, Beatriz, and Garcia-Nieto, Antonio Velez

Published
2018
Full Text
View/download PDF

13. Author-paper affiliation network architecture influences the methodological quality of systematic reviews and meta-analyses of psoriasis

Author

Luis Sanz-Cabanillas, Juan, Ruano, Juan, Gomez-Garcia, Francisco, Alcalde-Mellado, Patricia, Gay-Mimbrera, Jesus, Aguilar-Luque, Macarena, Maestre-Lopez, Beatriz, Gonzalez-Padilla, Marcelino, Carmona-Fernandez, Pedro J., Velez Garcia-Nieto, Antonio, Isla-Tejera, Beatriz, [Luis Sanz-Cabanillas, Juan] Reina Sofia Univ Hosp, Dept Dermatol, Cordoba, Spain, [Ruano, Juan] Reina Sofia Univ Hosp, Dept Dermatol, Cordoba, Spain, [Gomez-Garcia, Francisco] Reina Sofia Univ Hosp, Dept Dermatol, Cordoba, Spain, [Gonzalez-Padilla, Marcelino] Reina Sofia Univ Hosp, Dept Dermatol, Cordoba, Spain, [Carmona-Fernandez, Pedro J.] Reina Sofia Univ Hosp, Dept Dermatol, Cordoba, Spain, [Velez Garcia-Nieto, Antonio] Reina Sofia Univ Hosp, Dept Dermatol, Cordoba, Spain, [Luis Sanz-Cabanillas, Juan] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Ruano, Juan] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Gomez-Garcia, Francisco] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Alcalde-Mellado, Patricia] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Gay-Mimbrera, Jesus] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Aguilar-Luque, Macarena] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Maestre-Lopez, Beatriz] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Gonzalez-Padilla, Marcelino] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Carmona-Fernandez, Pedro J.] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Velez Garcia-Nieto, Antonio] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Isla-Tejera, Beatriz] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba, Spain, [Alcalde-Mellado, Patricia] Univ Cordoba, Sch Med, Cordoba, Spain, [Maestre-Lopez, Beatriz] Univ Cordoba, Sch Med, Cordoba, Spain, [Isla-Tejera, Beatriz] Reina Sofia Univ Hosp, Dept Pharm, Cordoba, Spain, National Plan of R+D+I, ISCIII-Subdireccion General de Evaluacion, European Regional Development Fund (ERDF), and Plan Propio de movilidad para investigadores del Institute Maimonides de Investigacion Biomedica de Cordoba (IMIBIC)

Subjects
Collaboration
Abstract

Moderate-to-severe psoriasis is associated with significant comorbidity, an impaired quality of life, and increased medical costs, including those associated with treatments. Systematic reviews (SRs) and meta-analyses (MAs) of randomized clinical trials are considered two of the best approaches to the summarization of high-quality evidence. However, methodological bias can reduce the validity of conclusions from these types of studies and subsequently impair the quality of decision making. As co-authorship is among the most well-documented forms of research collaboration, the present study aimed to explore whether authors' collaboration methods might influence the methodological quality of SRs and MAs of psoriasis. Methodological quality was assessed by two raters who extracted information from full articles. After calculating total and per-item Assessment of Multiple Systematic Reviews (AMSTAR) scores, reviews were classified as low (0-4), medium (5-8), or high (9-11) quality. Article metadata and journal-related bibliometric indices were also obtained. A total of 741 authors from 520 different institutions and 32 countries published 220 reviews that were classified as high (17.2%), moderate (55%), or low (27.7%) methodological quality. The high methodological quality subnetwork was larger but had a lower connection density than the low and moderate methodological quality subnetworks; specifically, the former contained relatively fewer nodes (authors and reviews), reviews by authors, and collaborators per author. Furthermore, the high methodological quality subnetwork was highly compart-mentalized, with several modules representing few poorly interconnected communities. In conclusion, structural differences in author-paper affiliation network may influence the methodological quality of SRs and MAs on psoriasis. As the author-paper affiliation network structure affects study quality in this research field, authors who maintain an appropriate balance between scientific quality and productivity are more likely to develop higher quality reviews.

Published
2017

15. Drugs targeting the JAK/STAT pathway for the treatment of immune-mediated inflammatory skin diseases: protocol for a scoping review

Author

Gómez-García, Francisco, primary, Gómez-Arias, Pedro Jesús, additional, Hernandez, Jorge, additional, Montilla, Ana María, additional, Gay-Mimbrera, Jesús, additional, Aguilar-Luque, Macarena, additional, Viguera-Guerra, Isabel, additional, Velez García-Nieto, Antonio, additional, Isla-Tejera, Beatriz, additional, and Ruano, Juan, additional

Published
2019
Full Text
View/download PDF

16. Evolution of international collaborative research efforts to develop non-Cochrane systematic reviews

Author

Viguera-Guerra, Isabel, primary, Ruano, Juan, additional, Aguilar-Luque, Macarena, additional, Gay-Mimbrera, Jesús, additional, Montilla, Ana, additional, Fernández-Rueda, Jose Luis, additional, Fernández-Chaichio, José, additional, Sanz-Cabanillas, Juan Luis, additional, Gómez-Arias, Pedro Jesús, additional, Vélez García-Nieto, Antonio, additional, Gómez-Garcia, Francisco, additional, and Isla-Tejera, Beatriz, additional

Published
2019
Full Text
View/download PDF

17. Additional file 5 of Abstract analysis method facilitates filtering low-methodological quality and high-bias risk systematic reviews on psoriasis interventions

Author

Gómez-García, Francisco, Ruano, Juan, Aguilar-Luque, Macarena, Alcalde-Mellado, Patricia, Gay-Mimbrera, Jesús, Hernández-Romero, José Luis, Sanz-Cabanillas, Juan Luis, Maestre-López, Beatriz, González-Padilla, Marcelino, Carmona-Fernández, Pedro J., García-Nieto, Antonio, and Isla-Tejera, Beatriz

Abstract

Appendix 3. List of non included studies and reasons for exclusion. (DOC 733 kb)

Published
2017
Full Text
View/download PDF

18. Additional file 3 of Abstract analysis method facilitates filtering low-methodological quality and high-bias risk systematic reviews on psoriasis interventions

Author

Gómez-García, Francisco, Ruano, Juan, Aguilar-Luque, Macarena, Alcalde-Mellado, Patricia, Gay-Mimbrera, Jesús, Hernández-Romero, José Luis, Sanz-Cabanillas, Juan Luis, Maestre-López, Beatriz, González-Padilla, Marcelino, Carmona-Fernández, Pedro J., García-Nieto, Antonio, and Isla-Tejera, Beatriz

Abstract

Appendix 5. Phase 2 domains and signaling questions of ROBIS tool. (DOC 32 kb)

Published
2017
Full Text
View/download PDF

19. Additional file 1 of Abstract analysis method facilitates filtering low-methodological quality and high-bias risk systematic reviews on psoriasis interventions

Author

Gómez-García, Francisco, Ruano, Juan, Aguilar-Luque, Macarena, Alcalde-Mellado, Patricia, Gay-Mimbrera, Jesús, Hernández-Romero, José Luis, Sanz-Cabanillas, Juan Luis, Maestre-López, Beatriz, González-Padilla, Marcelino, Carmona-Fernández, Pedro J., García-Nieto, Antonio, and Isla-Tejera, Beatriz

Abstract

Appendix 1. Supplementary materials and methods. (DOC 23 kb)

Published
2017
Full Text
View/download PDF

20. Additional file 2 of Abstract analysis method facilitates filtering low-methodological quality and high-bias risk systematic reviews on psoriasis interventions

Author

Gómez-García, Francisco, Ruano, Juan, Aguilar-Luque, Macarena, Alcalde-Mellado, Patricia, Gay-Mimbrera, Jesús, Hernández-Romero, José Luis, Sanz-Cabanillas, Juan Luis, Maestre-López, Beatriz, González-Padilla, Marcelino, Carmona-Fernández, Pedro J., García-Nieto, Antonio, and Isla-Tejera, Beatriz

Abstract

Appendix 4. AMSTAR checklist. (DOC 25 kb)

Published
2017
Full Text
View/download PDF

21. Additional file 6 of Abstract analysis method facilitates filtering low-methodological quality and high-bias risk systematic reviews on psoriasis interventions

Author

Gómez-García, Francisco, Ruano, Juan, Aguilar-Luque, Macarena, Alcalde-Mellado, Patricia, Gay-Mimbrera, Jesús, Hernández-Romero, José Luis, Sanz-Cabanillas, Juan Luis, Maestre-López, Beatriz, González-Padilla, Marcelino, Carmona-Fernández, Pedro J., García-Nieto, Antonio, and Isla-Tejera, Beatriz

Abstract

Appendix 6. PRISMA-A IRR using Fleiss’ Kappa for two raters. (DOC 16 kb)

Published
2017
Full Text
View/download PDF

22. Additional file 4 of Abstract analysis method facilitates filtering low-methodological quality and high-bias risk systematic reviews on psoriasis interventions

Author

Gómez-García, Francisco, Ruano, Juan, Aguilar-Luque, Macarena, Alcalde-Mellado, Patricia, Gay-Mimbrera, Jesús, Hernández-Romero, José Luis, Sanz-Cabanillas, Juan Luis, Maestre-López, Beatriz, González-Padilla, Marcelino, Carmona-Fernández, Pedro J., García-Nieto, Antonio, and Isla-Tejera, Beatriz

Abstract

Appendix 2. List of included studies. (DOC 86 kb)

Published
2017
Full Text
View/download PDF

23. Evolution of international collaborative research efforts to develop non-Cochrane systematic reviews

Author

Viguera-Guerra, I., primary, Ruano, Juan, additional, Aguilar-Luque, Macarena, additional, Gay-Mimbrera, Jesus, additional, Montilla, Ana, additional, Fernández-Rueda, J. L., additional, Fernández-Chaichio, J., additional, Sanz-Cabanillas, J.L., additional, Gómez-Arias, P., additional, García-Nieto, Antonio Velez, additional, Gómez-Garcia, Francisco, additional, and Isla-Tejera, Beatriz, additional

Published
2018
Full Text
View/download PDF

24. The differential impact of scientific quality, bibliometric factors, and social media activity on the influence of systematic reviews and meta-analyses about psoriasis

Author

Ruano, Juan, primary, Aguilar-Luque, Macarena, additional, Gómez-Garcia, Francisco, additional, Alcalde Mellado, Patricia, additional, Gay-Mimbrera, Jesus, additional, Carmona-Fernandez, Pedro J., additional, Maestre-López, Beatriz, additional, Sanz-Cabanillas, Juan Luís, additional, Hernández Romero, José Luís, additional, González-Padilla, Marcelino, additional, Vélez García-Nieto, Antonio, additional, and Isla-Tejera, Beatriz, additional

Published
2018
Full Text
View/download PDF

25. Abstract analysis method facilitates filtering low-methodological quality and high-bias risk systematic reviews on psoriasis interventions

Author

Gómez-García, Francisco, primary, Ruano, Juan, additional, Aguilar-Luque, Macarena, additional, Alcalde-Mellado, Patricia, additional, Gay-Mimbrera, Jesús, additional, Hernández-Romero, José Luis, additional, Sanz-Cabanillas, Juan Luis, additional, Maestre-López, Beatriz, additional, González-Padilla, Marcelino, additional, Carmona-Fernández, Pedro J., additional, García-Nieto, Antonio Vélez, additional, and Isla-Tejera, Beatriz, additional

Published
2017
Full Text
View/download PDF

26. Author-paper affiliation network architecture influences the methodological quality of systematic reviews and meta-analyses of psoriasis

Author

Sanz-Cabanillas, Juan Luis, primary, Ruano, Juan, additional, Gomez-Garcia, Francisco, additional, Alcalde-Mellado, Patricia, additional, Gay-Mimbrera, Jesus, additional, Aguilar-Luque, Macarena, additional, Maestre-Lopez, Beatriz, additional, Gonzalez-Padilla, Marcelino, additional, Carmona-Fernandez, Pedro J., additional, Velez Garcia-Nieto, Antonio, additional, and Isla-Tejera, Beatriz, additional

Published
2017
Full Text
View/download PDF

27. Stock Management in Hospital Pharmacy using Chance-Constrained Model Predictive Control

Author

Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Universidad de Sevilla. TEP116: Automatica y Robotica Industrial, Jurado, Isabel, Maestre Torreblanca, José María, Velarde, Pablo, Ocampo-Martínez, Carlos, Fernández, Isabel, Isla Tejera, Beatriz, Prado, José Ramón del, Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Universidad de Sevilla. TEP116: Automatica y Robotica Industrial, Jurado, Isabel, Maestre Torreblanca, José María, Velarde, Pablo, Ocampo-Martínez, Carlos, Fernández, Isabel, Isla Tejera, Beatriz, and Prado, José Ramón del

Abstract

One of the most important problems in the pharmacy department of a hospital is stock management. The clinical need for drugs must be satisfied with limited work labor while minimizing the use of economic resources. The complexity of the problem resides in the random nature of the drug demand and the multiple constraints that must be taken into account in every decision. In this article, chance-constrained model predictive control is proposed to deal with this problem. The flexibility of model predictive control allows taking into account explicitly the different objectives and constraints involved in the problem while the use of chance constraints provides a trade-off between conservativeness and efficiency. The solution proposed is assessed to study its implementation in two Spanish hospitals.

Published
2016

28. Stock management in hospital pharmacy using chance-constrained model predictive control

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control, Jurado, Isabel, Maestre Torreblanca, José María, Velarde, Pablo, Ocampo-Martínez, Carlos, Fernandez, Isabel, Isla Tejera, Beatriz, del Prado, José Ramón, Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control, Jurado, Isabel, Maestre Torreblanca, José María, Velarde, Pablo, Ocampo-Martínez, Carlos, Fernandez, Isabel, Isla Tejera, Beatriz, and del Prado, José Ramón

Abstract

One of the most important problems in the pharmacy department of a hospital is stock management. The clinical needs of drugs must be satisfied with limited work labor while minimizing the use of economical resources. The complexity of the problem resides in the random nature of the drug demand and the multiple constraints that must be taken into account in every decision. In this article, chance-constrained model predictive control is proposed to deal with this problem. The flexibility of model predictive control allows taking into account explicitly the different objectives and constraints involved in the problem while the use of chance constraints provides a trade-off between conservativeness and efficiency. The solution proposed is assessed to study its implementation in two Spanish hospitals, Peer Reviewed, Postprint (author's final draft)

Published
2016

30. Control Predictivo Aplicado a la Gestión de Stocks en Farmacia Hospitalaria: un Enfoque Orientado a la Minimización del Riesgo

Author

Maestre Torreblanca, José María, Zafra Cabeza, Ascensión, Fernández García. M.I., Isla Tejera, Beatriz, Prado, J.R. del, Camacho, Eduardo F., and Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática

Subjects
Sistemas de gestión, Social impact of automation, Stochastic system, Control Predictivo
Abstract

La gestión de stock es una de las principales tareas que lleva a cabo el Servicio de Farmacia de un hospital. Se trata de un problema complejo que requiere establecer un equilibrio entre criterios de optimización diferentes y, a veces, contrapuestos. La complejidad del problema se ve incrementada debido a la incorporación de restricciones tales como retrasos en las entregas de los medicamentos o variabilidad en la demanda. En este trabajo proponemos aplicar el control predictivo basado en modelo (MPC) al problema de gestión de stock de un Servicio de Farmacia desde una perspectiva de minimización del riesgo. Las acciones de mitigación se llevan a cabo con el objetivo de reducir el impacto de los posibles riesgos que pueden ocurrir. Por lo tanto, se añaden al problema inicial nuevas variables de decisión. Dado que estas variables pueden ser booleanas, el problema se formula como un problema de programación cuadrática mixto-entero. Finalmente, la metodología propuesta es utilizada en simulación utilizando datos procedentes de un hospital real. Inventory management is one of the main tasks that the pharmacy department has to carry out in a hospital. It is a complex problem that requires to establish a tradeoff between different and contradictory optimization criteria. The complexity of the problem is increased by the constrains that naturally arise in stock management problems such as variable delays or stochastic demands. In this work we propose to apply model predictive control (CPBM) to the pharmacy department inventory management problem from a risk mitigation perspective. Mitigation actions are executed to reduce the impact of the possible risks that may occur. Hence, new decision variables are added to the initial problem. Given that these variables may be boolean, the problem is formulated as a mixed integer quadratic programming. The proposed methodology is put to test in simulations based on data proceeding from a real hospital.

Published
2013

31. Stockout risk analysis and minimization applied to hospital pharmacy management

Author

Maestre Torreblanca, José María, Isla Tejera, Beatriz, Fernández García, María Isabel, Prado Llergo, Ramón del, Alamo, Teodoro, Camacho, Eduardo F., and Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática

Subjects
Stock fármacos, Gestión farmacia hospitalaria
Abstract

Permiso del editor Aula Médica para subir a idUS la versión editorial del artículo Determinar el valor que debería tomar el stock de seguridad de los fármacos dispensados en un hospital de tercer nivel en función del nivel de riesgo y del número de días que se desee resistir sin rotura de stock.

Published
2012

32. Análisis farmacogenético de la ciclosporina en relación a los factores farmacocinéticos-farmacodinámicos y la incidencia de rechazo agudo tras el trasplante cardíaco

Author

Isla Tejera, Beatriz, Universidad de Granada. Departamento de Bioquímica y Biología Molecular, Suárez García, Antonio, and Aumente Rubio, María Dolores

Subjects
Trasplantes de corazón, Farmacología
Abstract

Tesis Univ. Granada. Departamento de Bioquímica y Biología Molecular. Leída el 19 de septiembre de 2008

Published
2011

33. An application of chance-constrained model predictive control to inventory management in hospitalary pharmacy

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control, Maestre Torreblanca, José María, Velarde, Pablo, Jurado, Isabel, Ocampo-Martínez, Carlos, Isla Tejera, Beatriz, del Prado, José Ramón, Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control, Maestre Torreblanca, José María, Velarde, Pablo, Jurado, Isabel, Ocampo-Martínez, Carlos, Isla Tejera, Beatriz, and del Prado, José Ramón

Abstract

Inventory management is one of the main tasks that the pharmacy department has to carry out in a hospital. It is a complex problem that requires to establish a tradeoff between different and contradictory optimization criteria. The complexity of the problem is increased due to the constraints that naturally arise in this type of applications. In this paper, which corresponds to preliminary works performed to implement advanced control techniques for pharmacy management in two Spanish hospitals, we propose and assess chance-constrained model predictive control (CC-MPC) as a mean to relieve this issue., Peer Reviewed, Postprint (author’s final draft)

Published
2014

35. Control Predictivo Aplicado a la Gestión de Stocks en Farmacia Hospitalaria: un Enfoque Orientado a la Minimización del Riesgo

Author

Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Maestre Torreblanca, José María, Zafra Cabeza, Ascensión, Fernández García. M.I., Isla Tejera, Beatriz, Prado, J.R. del, Camacho, Eduardo F., Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Maestre Torreblanca, José María, Zafra Cabeza, Ascensión, Fernández García. M.I., Isla Tejera, Beatriz, Prado, J.R. del, and Camacho, Eduardo F.

Abstract

La gestión de stock es una de las principales tareas que lleva a cabo el Servicio de Farmacia de un hospital. Se trata de un problema complejo que requiere establecer un equilibrio entre criterios de optimización diferentes y, a veces, contrapuestos. La complejidad del problema se ve incrementada debido a la incorporación de restricciones tales como retrasos en las entregas de los medicamentos o variabilidad en la demanda. En este trabajo proponemos aplicar el control predictivo basado en modelo (MPC) al problema de gestión de stock de un Servicio de Farmacia desde una perspectiva de minimización del riesgo. Las acciones de mitigación se llevan a cabo con el objetivo de reducir el impacto de los posibles riesgos que pueden ocurrir. Por lo tanto, se añaden al problema inicial nuevas variables de decisión. Dado que estas variables pueden ser booleanas, el problema se formula como un problema de programación cuadrática mixto-entero. Finalmente, la metodología propuesta es utilizada en simulación utilizando datos procedentes de un hospital real., Inventory management is one of the main tasks that the pharmacy department has to carry out in a hospital. It is a complex problem that requires to establish a tradeoff between different and contradictory optimization criteria. The complexity of the problem is increased by the constrains that naturally arise in stock management problems such as variable delays or stochastic demands. In this work we propose to apply model predictive control (CPBM) to the pharmacy department inventory management problem from a risk mitigation perspective. Mitigation actions are executed to reduce the impact of the possible risks that may occur. Hence, new decision variables are added to the initial problem. Given that these variables may be boolean, the problem is formulated as a mixed integer quadratic programming. The proposed methodology is put to test in simulations based on data proceeding from a real hospital.

Published
2013

36. Análisis y minimización del riesgo de rotura de stock aplicado a la gestión en farmacia hospitalaria

Author

Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Maestre Torreblanca, José María, Isla Tejera, Beatriz, Fernández García, María Isabel, Prado Llergo, Ramón del, Alamo, Teodoro, Camacho, Eduardo F., Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Maestre Torreblanca, José María, Isla Tejera, Beatriz, Fernández García, María Isabel, Prado Llergo, Ramón del, Alamo, Teodoro, and Camacho, Eduardo F.

Abstract

Determinar el valor que debería tomar el stock de seguridad de los fármacos dispensados en un hospital de tercer nivel en función del nivel de riesgo y del número de días que se desee resistir sin rotura de stock.

Published
2012

38. Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report.

Author

Hernández J, Sanz A, Isla-Tejera B, and Ruano J

Abstract

Imatinib mesylate is a small tyrosine kinase inhibitor that targets BCR-ABL, ckit and platelet-derived growth factor receptor. It is prescribed by hematologists for chronic myeloid leukemia and acute lymphoblastic leukemia and by oncologists for Gastrointestinal Stromal Tumors (GIST). Cutaneous reactions to Imatinib are common but their incidence and severity widely varies between patients. A self-limited skin rash is the most common adverse effect but there have been reported cases of patients with maculopapular rash, pigmentary changes, superficial edema and rarer and clinically distinctive features such as lichenoid reactions or psoriasis. We here describe for the first time a case of pyoderma gangrenosum-like necrotizing panniculitis, a rare dermatological condition, after initiating therapy with Imatinib ., Competing Interests: Conflict of interest: The Authors declare no potential conflict of interests., (©Copyright: the Author(s).)

Published
2020
Full Text
View/download PDF

39. Stockout risk analysis and minimization applied to hospital pharmacy management.

Author

Maestre Torreblanca JM, Isla Tejera B, Fernández García MI, Del Prado Llergo JR, Alamo Cantarero T, and Fernández Camacho E

Subjects
Algorithms, Antibodies, Monoclonal economics, Harm Reduction, Infliximab, Models, Theoretical, Organizational Policy, Pharmacy Service, Hospital statistics & numerical data, Risk Assessment, Spain, Time Factors, Inventories, Hospital statistics & numerical data, Pharmaceutical Preparations supply & distribution, Pharmacy Service, Hospital organization & administration
Abstract

Objective: To determine how many dispensary drugs should be in the safety stock in a tertiary hospital in accordance with the risk level and the number of days that the hospital is able to withstand a stockout., Methods: We statistically analysed the infliximab order recorded over a period of 120 days. This drug is relevant for this study as it is costly and is immediately supplied to the clinic. Using the data records for purchasing and dispensing in our department, we created a table to compare the level of risk assumed with the number of units in stock and the number of days that the safety stock should last. In addition, we calculated how much stock there should be in accordance with different heuristic rules used by pharmacy departments., Results: In the period being studied, the daily order was 11.4±14.8 units of infliximab. Using the methodology proposed, we discovered that there should be 79 units in the safety stock. Other hospital rules determine values of 47 and 119 units., Conclusions: The method proposed allows us to discover the risk level that is assumed when selecting the safety stock. Therefore, we are able to design a safety stock policy consistent with the risk level adopted. Under certain assumptions the safety stock quota provided by this method could be reduced. Lastly, there is a notable difference between the safety stock values suggested by different rules, as it has been shown in this article., (Copyright © 2010 SEFH. Published by Elsevier Espana. All rights reserved.)

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results