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28 results on '"Ishizaki, Junzo"'

1. Prevalence of chromosome 8p11.2 translocations and correlation with myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in a consecutive cohort from nine institutions in Japan

Author

Usuki, Kensuke, Kameda, Takuro, Kawano, Noriaki, Ito, Tomoki, Hashimoto, Yoshinori, Shide, Kotaro, Kawano, Hiroshi, Sekine, Masaaki, Toyama, Takanori, Iizuka, Hiromitsu, Sato, Seiichi, Takeuchi, Masanori, Ishizaki, Junzo, Maeda, Kouichi, Nakai, Michikazu, Yamashita, Kiyoshi, Kubuki, Yoko, and Shimoda, Kazuya

Published
2024
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2. Impaired humoral immunity following COVID-19 vaccination in HTLV-1 carriers

Author

Kameda, Takuro, Utsunomiya, Atae, Otsuka, Nobuaki, Kubuki, Yoko, Uchida, Taisuke, Shide, Kotaro, Kamiunten, Ayako, Nakano, Nobuaki, Tokunaga, Masahito, Miyazono, Takayoshi, Ito, Yoshikiyo, Yonekura, Kentaro, Kawakita, Toshiro, Akizuki, Keiichi, Tahira, Yuki, Karasawa, Masayoshi, Hidaka, Tomonori, Konagata, Ayaka, Taniguchi, Norifumi, Nagatomo, Yuma, Kogo, Fumiko, Shimizu, Koichiro, Ueno, Hiroaki, Ishizaki, Junzo, Takahashi, Naoya, Ikei, Yoshihiko, Hidaka, Michihiro, Yamaguchi, Hideki, and Shimoda, Kazuya

Published
2024
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3. Early/prefibrotic primary myelofibrosis in patients who were initially diagnosed with essential thrombocythemia

Author

Kamiunten, Ayako, Shide, Kotaro, Kameda, Takuro, Ito, Masafumi, Sekine, Masaaki, Kubuki, Yoko, Hidaka, Tomonori, Akizuki, Keiichi, Tahira, Yuki, Toyama, Takanori, Kawano, Noriaki, Marutsuka, Kousuke, Maeda, Kouichi, Takeuchi, Masanori, Kawano, Hiroshi, Sato, Seiichi, Ishizaki, Junzo, Shimoda, Haruko, Yamashita, Kiyoshi, Matsuoka, Hitoshi, and Shimoda, Kazuya

Published
2018
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4. Thrombohemorrhagic events, disease progression, and survival in polycythemia vera and essential thrombocythemia: a retrospective survey in Miyazaki prefecture, Japan

Author

Kamiunten, Ayako, Shide, Kotaro, Kameda, Takuro, Sekine, Masaaki, Kubuki, Yoko, Ito, Masafumi, Toyama, Takanori, Kawano, Noriaki, Marutsuka, Kousuke, Maeda, Kouichi, Takeuchi, Masanori, Kawano, Hiroshi, Sato, Seiichi, Ishizaki, Junzo, Akizuki, Keiichi, Tahira, Yuki, Shimoda, Haruko, Hidaka, Tomonori, Yamashita, Kiyoshi, Matsuoka, Hitoshi, and Shimoda, Kazuya

Published
2018
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5. Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma

Author

Kameda, Takuro, primary, Shide, Kotaro, additional, Tahira, Yuki, additional, Sekine, Masaaki, additional, Sato, Seiichi, additional, Ishizaki, Junzo, additional, Takeuchi, Masanori, additional, Akizuki, Keiichi, additional, Kamiunten, Ayako, additional, Shimoda, Haruko, additional, Toyama, Takanori, additional, Maeda, Kouichi, additional, Yamashita, Kiyoshi, additional, Kawano, Noriaki, additional, Kawano, Hiroshi, additional, Hidaka, Tomonori, additional, Yamaguchi, Hideki, additional, Kubuki, Yoko, additional, Kitanaka, Akira, additional, Matsuoka, Hitoshi, additional, and Shimoda, Kazuya, additional

Published
2022
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6. Acute myeloid leukemia in clinical practice: a retrospective population-based cohort study in Miyazaki Prefecture, Japan

Author

Matsunaga, Takuya, Yamashita, Kiyoshi, Kubuki, Yoko, Toyama, Takanori, Imataki, Osamu, Maeda, Kouichi, Kawano, Noriaki, Satou, Seiichi, Kawano, Hiroshi, Ishizaki, Junzo, Yoshida, Shuro, Kameda, Takuro, Sasaki, Tadashi, Sekine, Masaaki, Kamiunten, Ayako, Taniguchi, Yasuhiro, Hidaka, Tomonori, Katayose, Keiko, K-Shimoda, Haruko, Shide, Kotaro, Yamamoto, Shojiro, Moritake, Hiroshi, Nunoi, Hiroyuki, Makino, Shigeyoshi, Kitanaka, Akira, Matsuoka, Hitoshi, and Shimoda, Kazuya

Published
2012
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7. Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture

Author

Kawano, Noriaki, Ochiai, Hidenobu, Yoshida, Shuro, Yamashita, Kiyoshi, Shide, Kotaro, Shimoda, Haruko, Hidaka, Tomonori, Kubuki, Yoko, Katayose, Keiko, Toyama, Takanori, Kawano, Hiroshi, Matsuoka, Hitoshi, Ishizaki, Junzo, Maeda, Koichi, Satou, Seiichi, Yano, Tatsuhiko, Yamaguchi, Kenichiro, Takenaka, Katsuto, Shimao, Yoshiya, Oshima, Koichi, Ueda, Akira, and Shimoda, Kazuya

Published
2012
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8. Real-World Data on Clinical Features, Outcomes, and Prognostic Factors in Multiple Myeloma from Miyazaki Prefecture, Japan

Author

Akizuki, Keiichi, primary, Matsuoka, Hitoshi, additional, Toyama, Takanori, additional, Kamiunten, Ayako, additional, Sekine, Masaaki, additional, Shide, Kotaro, additional, Kameda, Takuro, additional, Kawano, Noriaki, additional, Maeda, Kouichi, additional, Takeuchi, Masanori, additional, Kawano, Hiroshi, additional, Sato, Seiichi, additional, Ishizaki, Junzo, additional, Tahira, Yuki, additional, Shimoda, Haruko, additional, Hidaka, Tomonori, additional, Yamashita, Kiyoshi, additional, Kubuki, Yoko, additional, and Shimoda, Kazuya, additional

Published
2020
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9. Higher average chemotherapy dose intensity improves prognosis in patients with aggressive adult T‐cell leukemia/lymphoma

Author

Sekine, Masaaki, primary, Kameda, Takuro, additional, Shide, Kotaro, additional, Maeda, Kouichi, additional, Toyama, Takanori, additional, Kawano, Noriaki, additional, Takeuchi, Masanori, additional, Kawano, Hiroshi, additional, Sato, Seiichi, additional, Ishizaki, Junzo, additional, Kukita, Toshimasa, additional, Kamiunten, Ayako, additional, Akizuki, Keiichi, additional, Tahira, Yuki, additional, Shimoda, Haruko, additional, Hidaka, Tomonori, additional, Yamashita, Kiyoshi, additional, Matsuoka, Hitoshi, additional, Kitanaka, Akira, additional, Kubuki, Yoko, additional, and Shimoda, Kazuya, additional

Published
2020
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10. Higher average chemotherapy dose intensity improves prognosis in patients with aggressive adult T‐cell leukemia/lymphoma.

Author

Sekine, Masaaki, Kameda, Takuro, Shide, Kotaro, Maeda, Kouichi, Toyama, Takanori, Kawano, Noriaki, Takeuchi, Masanori, Kawano, Hiroshi, Sato, Seiichi, Ishizaki, Junzo, Kukita, Toshimasa, Kamiunten, Ayako, Akizuki, Keiichi, Tahira, Yuki, Shimoda, Haruko, Hidaka, Tomonori, Yamashita, Kiyoshi, Matsuoka, Hitoshi, Kitanaka, Akira, and Kubuki, Yoko

Subjects
ADULT T-cell leukemia, CANCER chemotherapy, T-cell lymphoma, LYMPHOMAS, PROGNOSIS
Abstract

Objective and Method: Adult T‐cell leukemia/lymphoma (ATL) is an aggressive peripheral T‐cell lymphoma with poor prognosis. We retrospectively reviewed the medical records of 312 patients with aggressive ATL and analyzed the effect of chemotherapy dose intensity on prognosis in clinical practice. Result: As first‐line therapy, 62 patients underwent best supportive care (BSC) or single‐agent chemotherapy, and 235 underwent intensive chemotherapy. The median survival time (MST) was 0.58 years in the 312 total patients, and 0.13 years and 0.75 years in the BSC/single‐agent chemotherapy group and intensive chemotherapy group, respectively. The median average relative dose intensity (ARDI) of patients who received intensive chemotherapy was 60%. We divided patients into 3 groups according to ARDI. Those in the top tertile of ARDI (ARDI ≥ 75%, n = 82) had better overall survival compared with those in the intermediate tertile (45% ≤ ARDI < 75%, n = 79) (P <.0001), with MSTs of 4.69 and 0.75 years, respectively. The occurrence of organ dysfunction and infectious complications was comparable between the two ARDI groups. Conclusion: Higher ARDI improves prognosis in patients with aggressive ATL in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Changes in hematologic parameters among Japanese HTLV-I carriers

Author

Welles, Seth L., Tachibana, Nobuyoshi, Orav, E. John, Okayama, Akihiko, Ishizaki, Junzo, and Mueller, Nancy E.

Subjects
HTLV-I infections -- Physiological aspects, blood -- analysis and chemistry, Carrier state (Communicable diseases) -- Physiological aspects, Health
Abstract

Changes in blood composition may occur in carriers of human T-cell lymphotropic virus type I (HTLV-I). HTLV-I has been associated with the development of adult T-cell leukemia and several other serious diseases. A disease carrier harbors the specific organisms of a disease without developing symptoms. Among 1,039 Japanese individuals who were tested for antibodies against HTLV-I, 32% were carriers of HTLV-I. Nine percent of the HTLV-I carriers were Ably positive, or had abnormal lymphocytes. Carriers with Ably had higher blood levels of lymphocytes than Ably negative carriers and non-carriers. Both groups of carriers had significantly lower blood levels of eosinophils and basophils. Carriers with Ably had significantly higher levels of red blood cells.

Published
1994

12. Suppression of delayed-type hypersensitivity to PPD and PHA in elderly HTLV-I carriers

Author

Murai, Koichi, Tachibana, Nobuyoshi, Shioiri, Shigemasa, Shishime, Eiichi, Okayama, Akihiko, Ishizaki, Junzo, Tsuda, Kazunori, and Mueller, Nancy

Subjects
Immunosuppression -- Causes of, Immunosuppression -- Demographic aspects, Aging -- Physiological aspects, Delayed hypersensitivity -- Testing, HTLV infections -- Physiological aspects, Virus-induced immunosuppression -- Analysis, Health
Abstract

The immune system of patients who are infected with human T-cell leukemia virus type I (HTLV-I) and have developed adult T-cell leukemia (ATL) is suppressed. However, the status of the immune system in carriers of HTLV-I, who are healthy and have no disease symptoms, is not certain. Previous studies have shown that the immune reaction to the tuberculin skin test, which measures delayed-type hypersensitivity (DTH), is suppressed in HTLV-I carriers in Japan, where HTLV-I infection is endemic. The suppression is more pronounced in individuals who are elderly, aged 60 years or older. Other types of DTH, reaction to purified protein derivative (PPD) of tuberculin and phytohemagglutinin (PHA), were examined in 56 patients, aged from 62 to 93 years old. The subjects were hospitalized with diseases that did not cause a suppression of the immune system. Twenty-two (39 percent) had antibodies to HTLV-I, indicating infection, but none had symptoms of disease caused by HTLV. There was an increased level of nonreactivity to PPD and PHA with increasing age. The degree of nonreactivity was greater in carriers than in non-carriers. Eighty-eight percent (15 out of 17) of HTLV-I carriers were nonreactive to both antigens, compared with 60 percent (15 out of 25) of non-carriers. Among the carriers who reacted to the antigens, the degree of reaction to PPD was reduced, but reaction to PHA was not reduced. These results confirm the finding that older individuals who are carriers of HTLV-I have reduced DTH response. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

13. Effects of mogamulizumab in adult T-cell leukemia/lymphoma in clinical practice

Author

Sekine, Masaaki, primary, Kubuki, Yoko, additional, Kameda, Takuro, additional, Takeuchi, Masanori, additional, Toyama, Takanori, additional, Kawano, Noriaki, additional, Maeda, Kouichi, additional, Sato, Seiichi, additional, Ishizaki, Junzo, additional, Kawano, Hiroshi, additional, Kamiunten, Ayako, additional, Akizuki, Keiichi, additional, Tahira, Yuki, additional, Shimoda, Haruko, additional, Shide, Kotaro, additional, Hidaka, Tomonori, additional, Kitanaka, Akira, additional, Yamashita, Kiyoshi, additional, Matsuoka, Hitoshi, additional, and Shimoda, Kazuya, additional

Published
2017
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14. Mogamulizumab for ATLL in Clinical Practice

Author

Sekine, Masaaki, primary, Takeuchi, Masaki, additional, Toyama, Takanori, additional, Maeda, Kouichi, additional, Sato, Seiichi, additional, Yamashita, Kiyoshi, additional, Ishizaki, Junzo, additional, Keiichi, Akizuki, additional, Kamiunten, Ayako, additional, Kameda, Takuro, additional, Shide, Kotaro, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Kitanaka, Akira, additional, and Shimoda, Kazuya, additional

Published
2016
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15. Prognostic Factor, Including Relative Dose Intensity, For Adult T-Cell Leukemia/Lymphoma In Clinical Practice

Author

Kamiunten, Ayako, primary, Kitanaka, Akira, additional, Kubuki, Yoko, additional, Hidaka, Tomonori, additional, Shide, Kotaro, additional, Kameda, Takuro, additional, Sekine, Masaaki, additional, Yamashita, Kiyoshi, additional, Matsuoka, Hitoshi, additional, Kawano, Hiroshi, additional, Toyama, Takanori, additional, Satou, Seiichi, additional, Maeda, Kouichi, additional, Ishizaki, Junzo, additional, and Shimoda, Kazuya, additional

Published
2013
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16. Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture

Author

Kawano, Noriaki, primary, Ochiai, Hidenobu, additional, Yoshida, Shuro, additional, Yamashita, Kiyoshi, additional, Shide, Kotaro, additional, Shimoda, Haruko, additional, Hidaka, Tomonori, additional, Kubuki, Yoko, additional, Katayose, Keiko, additional, Toyama, Takanori, additional, Kawano, Hiroshi, additional, Matsuoka, Hitoshi, additional, Ishizaki, Junzo, additional, Maeda, Koichi, additional, Satou, Seiichi, additional, Yano, Tatsuhiko, additional, Yamaguchi, Kenichiro, additional, Takenaka, Katsuto, additional, Shimao, Yoshiya, additional, Oshima, Koichi, additional, Ueda, Akira, additional, and Shimoda, Kazuya, additional

Published
2011
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20. Infections in Hematological Malignancies

Author

YOKOTA, Tsutomu, primary, SHISHIME, Eiichi, additional, OKAYAMA, Akihiko, additional, ISHIZAKI, Junzo, additional, MURAI, Koichi, additional, SHIOIRI, Shigemasa, additional, TACHIBANA, Nobuyoshi, additional, and TSUDA, Kazunori, additional

Published
1990
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23. Real-World Data on Clinical Features, Outcomes, and Prognostic Factors in Multiple Myeloma from Miyazaki Prefecture, Japan.

Author

Akizuki, Keiichi, Matsuoka, Hitoshi, Toyama, Takanori, Kamiunten, Ayako, Sekine, Masaaki, Shide, Kotaro, Kameda, Takuro, Kawano, Noriaki, Maeda, Kouichi, Takeuchi, Masanori, Kawano, Hiroshi, Sato, Seiichi, Ishizaki, Junzo, Tahira, Yuki, Shimoda, Haruko, Hidaka, Tomonori, Yamashita, Kiyoshi, Kubuki, Yoko, and Shimoda, Kazuya

Subjects
MULTIPLE myeloma, PROGNOSIS, STEM cell transplantation, DIAGNOSIS, MULTIVARIATE analysis, PLASMACYTOMA
Abstract

The prognosis of multiple myeloma (MM) has improved with the introduction of novel agents. These data are largely derived from clinical trials and might not reflect real-world patient outcomes accurately. We surveyed real-world data from 284 patients newly diagnosed with MM between 2010 and 2018 in Miyazaki Prefecture. The median follow-up period was 32.8 months. The median age at diagnosis was 71 years, with 68% of patients aged >65 years. The International Staging System (ISS) stage at diagnosis was I in 18.4% of patients, II in 34.1%, and III in 47.5%. Bortezomib-containing regimens were preferred as initial treatment; they were used in 147 patients (51.8%). In total, 80% of patients were treated with one or more novel agents (thalidomide, lenalidomide, or bortezomib). Among 228 patients who were treated with novel agents as an initial treatment, the overall response rate (partial response (PR) or better) to initial treatment was 78.4%, and the median time to next treatment (TTNT) was 11.6 months. In the multivariate analysis, PR or better responses to initial treatment were independently favorable prognostic factors for TTNT. The median survival time after initial therapy for patients with novel agents was 56.4 months and 3-year overall survival (OS) was 70.4%. In multivariate analysis, ISS stage I/II disease and PR or better response to initial treatment, and autologous stem cell transplantation (ASCT) were identified as independent prognostic factors for overall survival (OS). [ABSTRACT FROM AUTHOR]

Published
2021
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26. Two Cases of Spotted Fever Rickettsiosis in Kyushu

Author

TACHIBANA, Nobuyoshi, primary, SHISHIME, Eiichi, additional, OKAYAMA, Akihiko, additional, ISHIZAKI, Junzo, additional, MURAI, Koichi, additional, SHIOIRI, Shigemasa, additional, TSUDA, Kazunori, additional, and OSHIKAWA, Tatsumi, additional

Published
1987
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