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4. Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium

Author

Inker, Lesley A, Grams, Morgan E, Levey, Andrew S, Coresh, Josef, Cirillo, Massimo, Collins, John F, Gansevoort, Ron T, Gutierrez, Orlando M, Hamano, Takayuki, Heine, Gunnar H, Ishikawa, Shizukiyo, Jee, Sun Ha, Kronenberg, Florian, Landray, Martin J, Miura, Katsuyuki, Nadkarni, Girish N, Peralta, Carmen A, Rothenbacher, Dietrich, Schaeffner, Elke, Sedaghat, Sanaz, Shlipak, Michael G, Zhang, Luxia, van Zuilen, Arjan D, Hallan, Stein I, Kovesdy, Csaba P, Woodward, Mark, Levin, Adeera, Astor, Brad, Appel, Larry, Greene, Tom, Chen, Teresa, Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Yatsuya, Hiroshi, Tamakoshi, Koji, Li, Yuanying, Hirakawa, Yoshihisa, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Polkinghorne, Kevan, Chadban, Steven, Atkins, Robert, Djurdjev, Ognjenka, Liu, Lisheng, Zhao, Minghui, Wang, Fang, Wang, Jinwei, Ebert, Natalie, Martus, Peter, Tang, Mila, Heine, Gunnar, Emrich, Insa, Seiler, Sarah, Zawada, Adam, Nally, Joseph, Navaneethan, Sankar, Schold, Jesse, Shlipak, Michael, Sarnak, Mark, Katz, Ronit, Hiramoto, Jade, Iso, Hiroyasu, Yamagishi, Kazumasa, Umesawa, Mitsumasa, Muraki, Isao, Fukagawa, Masafumi, Maruyama, Shoichi, Hasegawa, Takeshi, Fujii, Naohiko, Wheeler, David, Emberson, John, Townend, John, Landray, Martin, Brenner, Hermann, Schöttker, Ben, Saum, Kai-Uwe, Fox, Caroline, Hwang, Shih-Jen, Köttgen, Anna, Schneider, Markus P, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, and Chang, Alex R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Women's Health, Clinical Research, Kidney Disease, Renal and urogenital, Good Health and Well Being, Aged, Albuminuria, Blood Chemical Analysis, Creatinine, Cross-Sectional Studies, Disease Progression, Female, Global Health, Glomerular Filtration Rate, Humans, Hypertension, Renal, Internationality, Kidney Function Tests, Male, Middle Aged, Predictive Value of Tests, Renal Insufficiency, Chronic, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Urinalysis, CKD Prognosis Consortium, CKD stage, Chronic kidney disease, albuminuria, anemia, diabetes, glomerular filtration rate, hematocrit, hemoglobin, hyperparathyroidism, hypertension, individual-level meta-analysis, kidney function, laboratory abnormality, laboratory tests, meta-analysis, serum bicarbonate, serum calcium, serum intact parathyroid hormone, serum phosphorus, serum potassium, staging system, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale & objectiveChronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.Study designCross-sectional individual participant-level analyses in a global consortium.Setting & study populations17 CKD and 38 general population and high-risk cohorts.Selection criteria for studiesCohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension.Data extractionData were obtained and analyzed between July 2015 and January 2018.Analytical approachWe modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses.ResultsThe CKD cohorts (n=254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n=1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59mL/min/1.73m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30mg/g).LimitationsVariations in study era, health care delivery system, typical diet, and laboratory assays.ConclusionsLower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

Published
2019

11. Association between hyperlipidemia and chronic kidney disease in a Japanese population; a cross-sectional study

Author

Shiraishi Ago, Yuko, Ishikawa, Yukiko, Ishikawa, Joji, Matsumura, Masami, and Ishikawa, Shizukiyo

Subjects
hypertriglyceridemia, cohort study, hyperlipidemia, chronic kidney disease
Abstract

Background: Strategies to prevent the development and progression of chronic kidney disease (CKD) are important in clinical practice as life expectancy increases. The present study investigated the prevalence of CKD as well as lipid profiles affecting CKD, especially triglyceride (TG) levels.Methods: In total, 5,169 subjects were eligible for a cross-sectional analysis of baseline data from the Jichi Medical School Cohort Study. We examined CKD subjects with an estimated glomerular filtration rate (eGFR) of less than 60 mL/ min/1.73m2 and independent factors associated with reductions in eGFR.Results: The prevalence of CKD was 17.7%. Age, systolic blood pressure, and hyperlipidemia were defined as related CKD factors. The lowest, second, third, and highest quartile ranges of total cholesterol (TC) were ≤166, 167-188, 189-212, and ≥213 mg/dL, respectively; the quartile ranges of TG were ≤71, 72-100, 101-148, and ≥149 mg/dL, respectively. The odds ratio (OR) of Q2 to Q4 of TC relative to that of Q1 for CKD increased linearly (OR [95%CI]: Q2, 1.3 [1.0-1.7]; Q3, 1.38 [1.1-1.8]; Q4, 1.5 [1.4-2.4]). The ORs of Q2 and Q3 of TG for CKD did not increase, whereas that of Q4 did (OR [95% CI]: Q2, 0.95 [0.7-1.2]; Q3, 0.98 [0.8-1.2]; Q4, 1.21 [1.0-1.5]).Conclusion: Increases in TC and TG levels were both independently associated with CKD. The relationship with CKD became stronger as TC increased, and the TG had threshold was 149 mg/dL.

Published
2023

12. Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH–JAPAN study

Author

Ueshima, Hirotsugu, Okamura, Tomonori, Imai, Yutaka, Ohkubo, Takayoshi, Irie, Fujiko, Iso, Hiroyasu, Kitamura, Akihiko, Ninomiya, Toshiharu, Kiyohara, Yutaka, Miura, Katsuyuki, Murakami, Yoshitaka, Nakagawa, Hideaki, Nakayama, Takeo, Okayama, Akira, Sairenchi, Toshimi, Saitoh, Shigeyuki, Sakata, Kiyomi, Tamakoshi, Akiko, Tsuji, Ichiro, Yamada, Michiko, Kiyama, Masahiko, Miyamoto, Yoshihiro, Ishikawa, Shizukiyo, Yatsuya, Hiroshi, Hirata, Aya, Sugiyama, Daisuke, Watanabe, Makoto, and Kotani, Kazuhiko

Published
2018
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18. Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan)

Author

Satoh, Michihiro, Ohkubo, Takayoshi, Asayama, Kei, Murakami, Yoshitaka, Sugiyama, Daisuke, Yamada, Michiko, Saitoh, Shigeyuki, Sakata, Kiyomi, Irie, Fujiko, Sairenchi, Toshimi, Ishikawa, Shizukiyo, Kiyama, Masahiko, Ohnishi, Hirofumi, Miura, Katsuyuki, Imai, Yutaka, Ueshima, Hirotsugu, and Okamura, Tomonori

Published
2018
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21. The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Author

Kashiwakura, Yuji, primary, Baatartsogt, Nemekhbayar, additional, Yamazaki, Shoji, additional, Nagao, Azusa, additional, Amano, Kagehiro, additional, Suzuki, Nobuaki, additional, Matsushita, Tadashi, additional, Sawada, Akihiro, additional, Higasa, Satoshi, additional, Yamasaki, Naoya, additional, Fujii, Teruhisa, additional, Ogura, Taemi, additional, Takedani, Hideyuki, additional, Taki, Masashi, additional, Matsumoto, Takeshi, additional, Yamanouchi, Jun, additional, Sakai, Michio, additional, Nishikawa, Masako, additional, Yatomi, Yutaka, additional, Yada, Koji, additional, Nogami, Keiji, additional, Watano, Ryota, additional, Hiramoto, Takafumi, additional, Hayakawa, Morisada, additional, Kamoshita, Nobuhiko, additional, Kume, Akihiro, additional, Mizukami, Hiroaki, additional, Ishikawa, Shizukiyo, additional, Sakata, Yoichi, additional, and Ohmori, Tsukasa, additional

Published
2022
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24. Dietitian‐supported dietary intervention leads to favorable dietary changes in patients with type 2 diabetes: A randomized controlled trial

Author

Kawabata, Nao, primary, Okada, Kenta, additional, Ando, Akihiko, additional, Kurashina, Tomoyuki, additional, Takahashi, Manabu, additional, Wakabayashi, Tetsuji, additional, Nagata, Daisuke, additional, Arakawa, Yukiko, additional, Haga, Atsuko, additional, Kogure, Ayako, additional, Chiba, Madoka, additional, Mogi, Satsuki, additional, Ishikawa, Shizukiyo, additional, and Ishibashi, Shun, additional

Published
2022
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32. Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population

Author

Imai, Yukiko, primary, Mizuno Tanaka, Sachiko, additional, Satoh, Michihiro, additional, Hirata, Takumi, additional, Murakami, Yoshitaka, additional, Miura, Katsuyuki, additional, Waki, Takashi, additional, Hirata, Aya, additional, Sairenchi, Toshimi, additional, Irie, Fujiko, additional, Sata, Mizuki, additional, Ninomiya, Toshiharu, additional, Ohkubo, Takayoshi, additional, Ishikawa, Shizukiyo, additional, Miyamoto, Yoshihiro, additional, Ohnishi, Hirofumi, additional, Saitoh, Shigeyuki, additional, Tamakoshi, Akiko, additional, Yamada, Michiko, additional, Kiyama, Masahiko, additional, Iso, Hiroyasu, additional, Sakata, Kiyomi, additional, Nakagawa, Hideaki, additional, Okayama, Akira, additional, Ueshima, Hirotsugu, additional, Okamura, Tomonori, additional, Imai, Yutaka, additional, Kitamura, Akihiko, additional, Kiyohara, Yutaka, additional, Harada, Akiko, additional, Sakurai, Masaru, additional, Nakayama, Takeo, additional, Tsuji, Ichiro, additional, Kokubo, Yoshihiro, additional, and Yatsuya, Hiroshi, additional

Published
2021
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33. Cardiovascular Prognosis in Drug-Resistant Hypertension Stratified by 24-Hour Ambulatory Blood Pressure: The JAMP Study

Author

Kario, Kazuomi, primary, Hoshide, Satoshi, additional, Narita, Keisuke, additional, Okawara, Yukie, additional, Kanegae, Hiroshi, additional, Aoki, Kenji, additional, Kihara, Hajime, additional, Koga, Toshiro, additional, Nakata, Tomoaki, additional, Oku, Kenji, additional, Matsuoka, Yasufumi, additional, Omori, Hiroaki, additional, Nishizawa, Masafumi, additional, Tanno, Yasuo, additional, Fukase, Yoko, additional, Omi, Koki, additional, Takahashi, Jun, additional, Mizuno, Hiroyuki, additional, Saito, Michiya, additional, Yatabe, Junichi, additional, Eguchi, Kazuo, additional, Iwashita, Kiyoshi, additional, Kumada, Maki, additional, Oki, Gaku, additional, Kabutoya, Tomoyuki, additional, Hojo, Yukihiro, additional, Ichida, Masaru, additional, Ishikawa, Shizukiyo, additional, Komori, Takahiro, additional, Matsui, Yoshio, additional, Matsumoto, Masatoshi, additional, Nagasaka, Shoichiro, additional, Nakano, Masahiro, additional, Nishimura, Yoshioki, additional, Okada, Kenta, additional, Shimada, Kazuyuki, additional, Shimpo, Masahisa, additional, Takahashi, Nozomu, additional, Uno, Hideyuki, additional, Ishikawa, Joji, additional, Kuroda, Toshio, additional, Hirahara, Nobutsune, additional, Kemi, Yuta, additional, Yoshioka, Hisashi, additional, Hoshi, Sakuo, additional, Mizuno, Atsuhi, additional, Ohno, Kunihiko, additional, Okazaki, Osamu, additional, Saito, Tsunehiro, additional, Tanaka, Tetsu, additional, Yamashiro, Kazuo, additional, Yamauchi, Tatsuyuki, additional, Yo, Shisei, additional, Yomogita, Shigeru, additional, Hikita, Sayaka, additional, Kawase, Yasuhiro, additional, Nojiri, Yoshifumi, additional, Sato, Yukihiro, additional, Uchiba, Kiyoshi, additional, Ishiguro, Motoyuki, additional, Taguchi, Atsushi, additional, Iida, Kazumasa, additional, Takemoto, Tatsuya, additional, Tone, Katsuyuki, additional, Abe, Hideyasu, additional, Abe, Yasuhisa, additional, Hasegawa, Masami, additional, Katsuya, Tomohiro, additional, Okada, Yoshiharu, additional, Tanaka, Shinichiro, additional, Tanke, Genyo, additional, Takami, Takeshi, additional, Michiura, Jun, additional, Shiotani, Masahiko, additional, Aoki, Tomohiro, additional, Ogura, Koichi, additional, Kawamura, Yuzuru, additional, Nakanishi, Shigekiyo, additional, Sasaki, Nobuo, additional, Takahashi, Toshiyuki, additional, Fujii, Akihisa, additional, Tanaka, Eiichiro, additional, Katayama, Hiroyuki, additional, Fukutomi, Motoki, additional, Miyoshi, Kosuke, additional, Naito, Hiroaki, additional, Yokota, Sawa, additional, Nakamura, Kazumasa, additional, Yokota, Tetsu, additional, Takasugi, Shinsuke, additional, Fujita, Shuichiro, additional, Fujita, Yumiko, additional, Kaneko, Hitoshi, additional, Fujiwara, Takeshi, additional, Kitamura, Wataru, additional, Anan, Yuhei, additional, Deguchi, Tomohiro, additional, Imaizumi, Yuki, additional, Miyagi, Jun, additional, Tsuji, Takahiro, additional, Uchiwa, Yasuhiro, additional, Ueda, Shin, additional, Yamaguchi, Takeya, additional, Yoshida, Tetsuro, additional, Yoshinaga, Ryo, additional, Maeda, Kosuke, additional, Kunitomo, Kotaro, additional, Soda, Kyousei, additional, Baba, Hirotoshi, additional, Yonezu, Keisuke, additional, Hino, Akihiro, additional, Miura, Genta, additional, Nakamura, Tomoko, additional, Kuroki, Munetoshi, additional, Omori, Fumihiko, additional, Hidaka, Toshiaki, additional, Hidaka, Takanori, additional, Yano, Yuichiro, additional, Kanemaru, Yoshimasa, additional, Kitani, Michitaka, additional, Koga, Masahiro, additional, Kubo, Hirohide, additional, Kuwabara, Masachika, additional, Miyata, Junichi, additional, Nagata, Masahiko, additional, Sasaki, Koji, additional, Tamaki, Noboru, additional, Tasaka, Hiroyasu, additional, Yokota, Naoto, additional, Miyata, Takahiro, additional, Katsuren, Eiyu, additional, Kudeken, Norifumi, additional, and Yagi, Noriharu, additional

Published
2021
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36. Comparison of the effects of frequent versus conventional nutritional interventions in patients with type 2 diabetes mellitus: A randomized, controlled trial

Author

Kawabata, Nao, primary, Okada, Kenta, additional, Ando, Akihiko, additional, Kurashina, Tomoyuki, additional, Takahashi, Manabu, additional, Wakabayashi, Tetsuji, additional, Nagata, Daisuke, additional, Kusano, Eiji, additional, Mogi, Satsuki, additional, Sato, Toshiko, additional, Ishikawa, Shizukiyo, additional, and Ishibashi, Shun, additional

Published
2021
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43. Abstract MP29: Combined Impact Of Chronic Kidney Disease And Hypertension On Lifetime Risk Of Cardiovascular Disease Death: A Pooled Analysis Of Data From The Evidence For Cardiovascular Prevention From Observational Cohorts In Japan Study

Author

Imai, Yukiko, primary, Sakurai, Masaru, additional, Hideaki, Nakagawa, additional, Hirata, Aya, additional, Murakami, Yoshitaka, additional, Tanaka, Sachiko, additional, Kiyohara, Yutaka, additional, Ninomiya, Toshiharu, additional, Ishikawa, Shizukiyo, additional, Saitoh, Shigeyuki, additional, Irie, Fujiko, additional, Sairenchi, Toshimi, additional, Kiyama, Masahiko, additional, Miura, Katsuyuki, additional, Ueshima, Hirotsugu, additional, and Okamura, Tomonori, additional

Published
2021
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46. 夫婦それぞれの出身地で地域医療に従事する自治医大卒業医師の生活満足度

Author

Nakamura, Takashi, Makino, Nobuko, Ishikawa, Yukiko, Kojima, Karin, Yamamoto, Sayaka, Yamamoto, Tomomi, Arai, Yuki, Watanabe, Arisa, Yoko, Kazumi, Yokotani, Tomoyo, Shiaraishi, Yuko, Toeda, Megumi, Sadakane, Atsuko, Mieno, Makiko, and Ishikawa, Shizukiyo

Subjects
human relations, rural practice, 結婚, 地域医療, home prefecture, 生活の満足度, life satisfaction, 人間関係, marriage, 出身地
Abstract

Introduction: Physicians reported poor life satisfaction (LS). Satisfaction with work–life balance also affects a physician’s career. Medical students of Jichi Medical University (JMU) are bound by a contract to practice under rural settings for several years after graduation. Among these students, there are couples who are both graduates. Thus, support for those in charge of rural practice is expected. This study aimed to explore factors related to LS in one’s own or partner’s home prefectures.Methods: A cross-sectional observation study was carried out, in which designated questionnaires were sent to 210 medical graduates (105 couples) from JMU between 2006 and 2010 who were engaged in rural practice. The main outcome was LS measured using the visual analog scale. LS of own or partner’s home prefecture was compared in terms of concerns, and supporters.Results: The response rate was 67%. The median of LS of own and partner’s home prefecture was 70 and 74, respectively. The major concern was “difficulty in receiving support from parents” (40%). The major supporter was “partner” (85%). “trouble with human relations” was related to lower LS in either home prefecture. Concerns, such as “inconvenience”, “community acceptance”, and “relationship with Kenjinkai”, were also related to lower LS in partner’s home prefecture but not in one’s own home prefecture. “Boss” acting as a good supporter was related to high LS in one’s own home prefecture.Conclusions: Good human relations are associated with LS in both own and partner’s home prefectures. In partners’ home prefectures, more factors are related to LS of physicians assigned to rural community. It may also be effective to involve the support of bosses.

Published
2018

48. Psychosocial job characteristics and risk of mortality in a Japanese community-based working population: The Jichi Medical School Cohort Study

Author

Tsutsumi, Akizumi, Kayaba, Kazunori, Hirokawa, Kumi, and Ishikawa, Shizukiyo

Subjects
Medical colleges -- Psychological aspects, Medical colleges -- Health aspects, Job stress -- Psychological aspects, Job stress -- Health aspects, Mortality -- Psychological aspects, Oncology, Experimental -- Psychological aspects, Oncology, Experimental -- Health aspects, Cancer -- Research, Cancer -- Psychological aspects, Cancer -- Health aspects, Health, Social sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.socscimed.2006.03.028 Byline: Akizumi Tsutsumi (a), Kazunori Kayaba (b), Kumi Hirokawa (c), Shizukiyo Ishikawa (d) Keywords: Cardiovascular diseases; Cohort studies; Mortality; Neoplasms; Stress; Psychological; Workplace; Japan Abstract: We prospectively investigated the association between psychosocial job characteristics according to the job demand-control model and the risk of mortality in a Japanese community-based working population. A baseline examination conducted from 1992 to 1995 determined the socioeconomic, behavioural, and biological risks in addition to the psychosocial job characteristics of 3178 male and 3331 female workers aged 65 and under and free from cancer and cardiovascular diseases. During the 9-year follow-up study, 157 men and 64 women died. In the follow-up, the results of Cox proportional hazards regression analysis revealed that men with concurrent high job demands and high job control (an active job) had the lowest risk of mortality from all causes. Compared with the low demand and high control job category, the multivariate relative risk of an active job was 0.53 (95% confidence interval: 0.31, 0.89). This finding appeared largely attributable to a reduction in cancer mortality. Job characteristics were not associated with cardiovascular diseases or external causes of mortality. For women, no significant associations were observed. The findings suggest that an active job has a beneficial effect on the health of Japanese male workers. Investigating of the effect of psychosocial job characteristics on cancer might therefore provide valuable insights into the health of workers. Author Affiliation: (a) University of Occupational and Environmental Health, Japan (b) Saitama Prefectural University, Japan (c) Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan (d) Jichi Medical School, Japan

Published
2006

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