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1,027 results on '"Ishikawa, Eiichi"'

2. Comparative analyses of immune cells and alpha-smooth muscle actin-positive cells under the immunological microenvironment between with and without dense fibrosis in primary central nervous system lymphoma

Author

Takei, Jun, Maeda, Miku, Fukasawa, Nei, Kawashima, Masaharu, Miyake, Misayo, Tomoto, Kyoichi, Nawate, Shohei, Teshigawara, Akihiko, Suzuki, Tomoya, Yamamoto, Yohei, Nagashima, Hiroyasu, Mori, Ryosuke, Fukushima, Ryoko, Matsushima, Satoshi, Kino, Hiroyoshi, Muroi, Ai, Tsurubuchi, Takao, Sakamoto, Noriaki, Nishiwaki, Kaichi, Yano, Shingo, Hasegawa, Yuzuru, Murayama, Yuichi, Akasaki, Yasuharu, Shimoda, Masayuki, Ishikawa, Eiichi, and Tanaka, Toshihide

Published
2024
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23. Symptomatic Cerebellar Cyst Formation after Foramen Magnum Meningioma Removal: A Case Report.

Author

Hanai, Sho, Yanaka, Kiyoyuki, Onuma, Kuniyuki, Nakamura, Kazuhiro, Kajita, Michihide, Aiyama, Hitoshi, and Ishikawa, Eiichi

Subjects
FORAMEN magnum, CEREBELLAR tumors, CHECK valves, CEREBROSPINAL fluid, SURGICAL complications, LAMINECTOMY
Abstract

Background Symptomatic cerebellar cyst formation after surgery is rare and the mechanism remains unknown. We describe a cerebellar cyst that gradually expanded, becoming symptomatic, after the removal of a foramen magnum meningioma and discuss the mechanism of cyst formation. Case Description A 76-year-old woman with a tumor at the foramen magnum was treated by posterior fossa craniotomy and C1 hemilaminectomy. The patient suddenly developed cerebellar symptoms and consciousness disturbance approximately 1 week into an otherwise good postoperative course. Imaging showed a subcutaneous pseudomeningocele in the occipital region and cerebellar cyst formation. After resolution by fenestration of the cerebellar cyst and duraplasty, the patient's symptoms gradually improved. No tumor or cerebellar cyst recurrence has been detected in over 5 years since the surgery. Conclusion Postoperative pseudomeningocele appeared crucial for cerebellar cyst formation. Postoperative development of symptomatic cerebellar cysts is rare but should be recognized as a serious, sometimes life-threatening, postoperative complication of posterior fossa surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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24. A Case of Idiopathic Intracranial Hypertension Complicated with both Infratentorial and Supratentorial Cortical Superficial Siderosis: Novel Imaging Findings on Intravoxel Incoherent Motion Magnetic Resonance Imaging Offering Clues to Pathophysiology.

Author

Watanabe, Shinya, Shibata, Yasushi, and Ishikawa, Eiichi

Subjects
MAGNETIC resonance imaging, HEARING disorders, CEREBROSPINAL fluid examination, CEREBRAL cortex, INTRACRANIAL pressure
Abstract

The pathology of idiopathic intracranial hypertension (IIH), a disease characterized by papillary edema and increased intracranial pressure (IICP), is not yet understood; this disease significantly affects quality of life due to symptoms including vision loss, headache, and pulsatile tinnitus. By contrast, superficial siderosis (SS), a disorder in which hemosiderin is deposited on the surface of the cerebral cortex and cerebellum, potentially causes cerebellar ataxia or hearing loss. So far, no cases of IIH with infratentorial and supratentorial cortical SS have been reported. Herein, we report a case of a 31-year-old woman with obesity who developed this condition. The patient suddenly developed headache and dizziness, had difficulty walking, and subsequently became aware of diplopia. Fundus examination revealed bilateral optic nerve congestive papillae and right eye abducens disturbance. Head magnetic resonance imaging (MRI) showed prominent SS on the cerebellar surface and cerebral cortex. Lumbar puncture revealed IICP of 32 cmH2O, consistent with the diagnostic criteria for IIH, and treatment with oral acetazolamide was started; subsequently, the intracranial pressure decreased to 20 cmH2O. Her abduction disorder disappeared, and the swelling of the optic papilla improved. She was now able return to her life as a teacher without any sequelae. SS is caused by persistent slight hemorrhage into the subarachnoid space. In this case, both infratentorial and supratentorial cortical superficial SS was observed. Although cases of IIH complicated by SS are rare, it should be kept in mind that a causal relationship between IIH and SS was inferred from our case. Our findings also suggest that cerebrospinal fluid dynamic analysis using MRI is effective in diagnosing IIH and in determining the efficacy of treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Efficacy and safety of nivolumab in Japanese patients with first recurrence of glioblastoma: an open-label, non-comparative study

Author

Aoki, Tomokazu, Kagawa, Naoki, Sugiyama, Kazuhiko, Wakabayashi, Toshihiko, Arakawa, Yoshiki, Yamaguchi, Shigeru, Tanaka, Shota, Ishikawa, Eiichi, Muragaki, Yoshihiro, Nagane, Motoo, Nakada, Mitsutoshi, Suehiro, Satoshi, Hata, Nobuhiro, Kuroda, Junichiro, Narita, Yoshitaka, Sonoda, Yukihiko, Iwadate, Yasuo, Natsumeda, Manabu, Nakazato, Yoichi, Minami, Hironobu, Hirata, Yuki, Hagihara, Shunsuke, and Nishikawa, Ryo

Published
2021
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28. Risk factors for psychological distress in electroencephalography technicians during the COVID-19 pandemic: A national-level cross-sectional survey in Japan

Author

Kanemoto, Kousuke, Ikeda, Akio, Terada, Kiyohito, Goji, Hiroko, Ohara, Shinji, Hagiwara, Koichi, Kamada, Takashi, Iida, Koji, Ishikawa, Nobutsune, Shiraishi, Hideaki, Iwata, Osato, Sugano, Hidenori, Iimura, Yasushi, Higashi, Takuichiro, Hosoyama, Hiroshi, Hanaya, Ryosuke, Shimotake, Akihiro, Kikuchi, Takayuki, Yoshida, Takeshi, Shigeto, Hiroshi, Yokoyama, Jun, Mukaino, Takahiko, Kato, Masaaki, Sekimoto, Masanori, Mizobuchi, Masahiro, Aburakawa, Yoko, Iwasaki, Masaki, Nakagawa, Eiji, Iwata, Tomohiro, Tokumoto, Kentaro, Nishida, Takuji, Takahashi, Yukitoshi, Kikuchi, Kenjiro, Matsuura, Ryuki, Hamano, Shin-ichiro, Yamanouchi, Hideo, Watanabe, Satsuki, Fujimoto, Ayataka, Enoki, Hideo, Tomoto, Kyoichi, Watanabe, Masako, Takubo, Youji, Fukuchi, Toshihiko, Nakamoto, Hidetoshi, Kubota, Yuichi, Kunii, Naoto, Shirota, Yuichiro, Ishikawa, Eiichi, Nakasato, Nobukazu, Maehara, Taketoshi, Inaji, Motoki, Takagi, Shunsuke, Enokizono, Takashi, Masuda, Yosuke, Hayashi, Takahiro, Kuroda, Naoto, Kubota, Takafumi, Horinouchi, Toru, Ikegaya, Naoki, Kitazawa, Yu, Kodama, Satoshi, Matsubara, Teppei, Nagino, Naoto, Neshige, Shuichiro, Soga, Temma, Sone, Daichi, Takayama, Yutaro, and Kuramochi, Izumi

Published
2021
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29. Transient Hemichorea-hemiballism Induced by a Combination of Postprandial Hypotension and Severe Stenosis of the Innominate Artery Concomitant with Left Carotid Occlusion

Author

Okune, Sho, primary, Hayakawa, Mikito, additional, Hino, Tenyu, additional, Hiramine, Takato, additional, Akimoto, Taisuke, additional, Sato, Masayuki, additional, Ito, Yoshiro, additional, Marushima, Aiki, additional, Takada, Tomoya, additional, Ishikawa, Eiichi, additional, Tamaoka, Akira, additional, and Matsumaru, Yuji, additional

Published
2024
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35. Effect of Sleep Deprivation on Simulated Microsurgical Vascular Anastomosis.

Author

Ito, Yoshiro, Hafez, Ahmad, Hosoo, Hisayuki, Marushima, Aiki, Matsumaru, Yuji, and Ishikawa, Eiichi

Subjects
SLEEP deprivation, SURGICAL anastomosis, NEUROSURGEONS
Abstract

Background The effects of sleep deprivation on surgical performance have been well documented. However, reports on the effects of sleep deprivation on microneurosurgery are limited. This study aimed to investigate the effects of sleep deprivation on microneurosurgery. Methods Ten neurosurgeons participated in the anastomosis of a vessel model using a microscope in sleep-deprived and normal states. We evaluated the procedure time (PT), stitch time (ST), interval time (IT), number of unachieved movements (NUM), leak rate, and practical scale for anastomosis quality assessment. Each parameter was compared between normal and sleep-deprived states. Subanalyses were performed on the two groups based on PT and NUM under the normal state (proficient and nonproficient groups). Results Although no significant differences were noted in PT, ST, NUM, leak rate, or practical scale, IT was significantly prolonged under sleep deprivation compared with the normal state (mean: 258.8 ± 94.0 vs. 199.3 ± 74.9 seconds; p = 0.02). IT was significantly prolonged under sleep deprivation in the nonproficient group based on both PT and NUM (PT: 234.2 ± 71.6 vs. 321.2 ± 44.7 seconds, p = 0.04; NUM: 173.3 ± 73.6 vs. 218.7 ± 97.7; p = 0.02), whereas no significant difference was observed in the proficient group (PT: 147.0 ± 47.0 vs. 165.3 ± 61.1 seconds, p = 0.25; NUM: 173.3 ± 73.6 vs. 218.7 ± 97.7; p = 0.25). Conclusions Although IT was significantly prolonged under sleep deprivation in the nonproficient group, there was no decline in performance skills in either the proficient or nonproficient group. The effect of sleep deprivation may require caution in the nonproficient group, but it is possible that certain microneurosurgical outcomes can be achieved under sleep deprivation. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Synthesis of Gd-DTPA Carborane-Containing Compound and Its Immobilization on Iron Oxide Nanoparticles for Potential Application in Neutron Capture Therapy.

Author

Korolkov, Ilya V., Zaboronok, Alexander, Izbasar, Kairat A., Bekbol, Zhangali A., Lissovskaya, Lana I., Zibert, Alexandr V., Shakirzyanov, Rafael I., Korganbayeva, Luiza N., Yang, Haolan, Ishikawa, Eiichi, and Zdorovets, Maxim V.

Subjects
IRON oxide nanoparticles, NEUTRON capture, IRON oxides, GADOLINIUM, THERMOGRAVIMETRY, MAGNETIC nanoparticles, TRANSMISSION electron microscopy
Abstract

Cancer is one of the leading causes of global mortality, and its incidence is increasing annually. Neutron capture therapy (NCT) is a unique anticancer modality capable of selectively eliminating tumor cells within normal tissues. The development of accelerator-based, clinically mountable neutron sources has stimulated a worldwide search for new, more effective compounds for NCT. We synthesized magnetic iron oxide nanoparticles (NPs) that concurrently incorporate boron and gadolinium, potentially enhancing the effectiveness of NCT. These magnetic nanoparticles underwent sequential modifications through silane polycondensation and allylamine graft polymerization, enabling the creation of functional amino groups on their surface. Characterization was performed using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), dynamic light scattering (DLS), thermal gravimetric analysis (TGA), and transmission electron microscopy (TEM). ICP-AES measurements indicated that boron (B) content in the NPs reached 3.56 ppm/mg, while gadolinium (Gd) averaged 0.26 ppm/mg. Gadolinium desorption was observed within 4 h, with a peak rate of 61.74%. The biocompatibility of the NPs was confirmed through their relatively low cytotoxicity and sufficient cellular tolerability. Using NPs at non-toxic concentrations, we obtained B accumulation of up to 5.724 × 1010 atoms per cell, sufficient for successful NCT. Although limited by its content in the NP composition, the Gd amount may also contribute to NCT along with its diagnostic properties. Further development of the NPs is ongoing, focusing on increasing the boron and gadolinium content and creating active tumor targeting. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Hidden Bow Hunter's Syndrome Diagnosed Using Dynamic Cerebral Angiography and Successfully Treated with Spinal Surgery: A Case Report and Review of the Literature

Author

Miyamoto, Satoshi, primary, Hayakawa, Mikito, additional, Okune, Sho, additional, Shintoku, Ryosuke, additional, Yamano, Akinari, additional, Hiramine, Takato, additional, Takahashi, Toshihide, additional, Hosoo, Hisayuki, additional, Ito, Yoshiro, additional, Marushima, Aiki, additional, Koda, Masao, additional, Ishikawa, Eiichi, additional, and Matsumaru, Yuji, additional

Published
2024
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48. CTNI-72. PHASE II TRIAL OF PATHOLOGY-BASED THREE-GROUP TREATMENT STRATIFICATION FOR PATIENTS WITH CNS GERM CELL TUMORS: A LONG-TERM FOLLOW-UP STUDY

Author

Fulvio D'Angelo, Hirokazu Takami, primary, Suzuki, Tomonari, additional, Takabatake, Kazuhiko, additional, Fujimaki, Takamitsu, additional, Okamoto, Michinari, additional, Yamaguchi, Shigeru, additional, Kanamori, Masayuki, additional, Matsuda, Kenichiro, additional, Sonoda, Yukihiko, additional, Natsumeda, Manabu, additional, Ichinose, Junya, additional, Nakada, Mitsutoshi, additional, Muroi, Ai, additional, Ishikawa, Eiichi, additional, Takahashi, Masamichi, additional, Narita, Yoshitaka, additional, Higuchi, Fumi, additional, Shin, Masahiro, additional, Mineharu, Yohei, additional, Arakawa, Yoshiki, additional, Kagawa, Naoki, additional, Kawabata, Shinji, additional, Wanibuchi, Masahiko, additional, Takayasu, Takeshi, additional, Yamasaki, Fumiyuki, additional, Fujii, Kentaro, additional, Ishida, Joji, additional, Date, Isao, additional, Miyake, Keisuke, additional, Fujioka, Hiroshi, additional, Kuga, Daisuke, additional, Yamashita, Shinji, additional, Takeshima, Hideo, additional, Shinojima, Naoki, additional, Mukasa, Akitake, additional, Tanaka, Shota, additional, Asai, Akio, additional, Nishikawa, Ryo, additional, and Matsutani, Masao, additional

Published
2023
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