6,747 results on '"Ishida H."'
Search Results
2. Three-Year Outcomes of Immediate Primary Phacoemulsification on Acute Primary Angle Closure Eyes and the Fellow Eyes
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Suzuki T, Fujishiro T, Tachi N, Ueta Y, Okamoto Y, Fukutome T, Sasajima H, Ishida H, Watanabe Y, and Hashimoto Y
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acute primary angle closure ,fellow eye ,long-term outcome ,phacoemulsification ,Ophthalmology ,RE1-994 - Abstract
Takafumi Suzuki,1,2 Takashi Fujishiro,2 Naoko Tachi,1,3 Yoshiki Ueta,1 Yasuhiro Okamoto,1 Takao Fukutome,1 Hirofumi Sasajima,1 Hidetoshi Ishida,1,4 Yuji Watanabe,1 Yoshihiro Hashimoto1 1Department of Ophthalmology, Shinseikai Toyama Hospital, Imizu, Japan; 2Department of Ophthalmology, The University of Tokyo Hospital, Bunkyo, Japan; 3Tachi Eye Clinic, Toyama, Japan; 4Department of Ophthalmology, Kanazawa Medical University, Ishikawa, JapanCorrespondence: Takashi Fujishiro, Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongō, Bunkyō-ku, Tokyo, 113-8655, Japan, Tel +81-3-3815-5411, Email fujishiro.tky@gmail.comPurpose: This study investigated the long-term outcomes (> 3 years) of immediate primary phacoemulsification in eyes with acute primary angle closure (APAC) and in the fellow eyes with shallow anterior chamber to prevent APAC development.Patients and Methods: This is a retrospective study of phacoemulsification for APAC using bilateral eyes. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), and number of IOP-lowering medications at the preoperative examination (Pre), postoperative month 1 (1m), year 3 (3y), and last visit were compared between 14 eyes with APAC and their 14 fellow eyes. The number of corneal endothelial cells (CECs) at Pre and at more than 2 weeks after phacoemulsification was compared. The visual field mean deviation (MD) within 1 year after phacoemulsification and at the last visit was also compared.Results: For APAC eyes, BCVA was significantly improved at 1m, 3y, and at the last visit as compared with Pre (p < 0.05). IOP significantly decreased at 1m, 3y, and at the last visit compared with Pre (p < 0.05). IOP-lowering medication use decreased significantly from Pre to 1m (p < 0.05). The number of CECs was not significantly different between Pre and more than 2 weeks after phacoemulsification. BCVA was significantly worse in APAC eyes than in fellow eyes at Pre (p < 0.05). IOP and the number of IOP-lowering medications were significantly higher in APAC eyes than in fellow eyes at Pre (p < 0.05).Conclusion: Primary phacoemulsification improved visual acuity for APAC eyes and maintained good IOP control without the need for reoperation. Moreover, it preserved the number of CECs for the APAC and fellow eyes in the long term.Keywords: acute primary angle closure, fellow eye, long-term outcome, phacoemulsification
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- 2023
3. Crystal structure of bis(guanidinium) tetrachlorozincate, [C(NH2)3]2ZnCl4
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Furukawa Y., Ishida H., and Kashino S.
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Physics ,QC1-999 ,Crystallography ,QD901-999 - Published
- 1999
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4. Surface band structure of the reconstructed Ir(001)-(5×1) surface
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Ishida, H., primary
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- 2024
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5. Wafer-scale on-chip synthesis and field emission properties of vertically aligned boron nitride based nanofiber arrays
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Long, H, Pham, T, Yan, A, Guo, Z, Ishida, H, Shi, W, Turner, S, Gilbert, SM, and Zettl, A
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Applied Physics ,Engineering ,Physical Sciences ,Technology - Abstract
One dimensional boron nitride (BN) nanomaterials with a high aspect ratio are of great interest due to their unique properties and potential applications. However, BN nanomaterials are generally difficult to synthesize. Here, we describe the creation of arrays of vertically aligned pure BN nanofibers and BN coated carbon nanofibers, fabricated on-chip via a straightforward template-assisted chemical conversion reaction. The template, a glassy carbon nanofiber array, is produced by plasma processing of conventional photoresists. The method is highly controllable, patternable, and scalable, and the final arrays can be fabricated over large areas with a controlled fiber length. We characterize the electron field emission properties of the BN-coated carbon nanofiber array and find a large field enhancement factor, low turn-on voltage, and good stability. The outstanding field emission performance results from the small tip size and high aspect ratio of the nanofiber as well as the high chemical stability and high thermal conductivity of the BN coating.
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- 2019
6. Superionic diffusion through frustrated energy landscape
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Di Stefano, D., Miglio, A., Robeyns, K., Filinchuk, Y., Lechartier, M., Senyshyn, A., Ishida, H., Spannenberger, S., Prutsch, D., Lunghammer, S., Rettenwander, D., Wilkening, M., Roling, B., Kato, Y., and Hautier, G.
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Condensed Matter - Materials Science ,Physics - Classical Physics - Abstract
Solid-state materials with high ionic conduction are necessary to many technologies including all-solid-state Li-ion batteries. Understanding how crystal structure dictates ionic diffusion is at the root of the development of fast ionic conductors. Here, we show that LiTi2(PS4)3 exhibits a Li-ion diffusion coefficient about an order of magnitude higher than current state-of-the-art lithium superionic conductors. We rationalize this observation by the unusual crystal structure of LiTi2(PS4)3 which offers no regular tetrahedral or octahedral sites for lithium to favorably occupy. This creates a smooth, frustrated energy landscape resembling more the energy landscapes present in liquids than in typical solids. This frustrated energy landscape leads to a high diffusion coefficient combining low activation energy with a high pre-factor.
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- 2017
7. Evaluation of Swallowing Function after Esophagectomy Using High-Resolution Manometry
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Koseki, K., primary, Sato, C., additional, Taniyama, Y., additional, Okamoto, H., additional, Ozawa, Y., additional, Ishida, H., additional, Kanabuchi, S., additional, Muranami, Y., additional, Fusegawa, K., additional, and Kamei, T., additional
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- 2024
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8. Outcomes of Pediatric Patients Transferred for Berlin Heart Excor Implantation
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Kido, T., primary, Taira, M., additional, Watanabe, T., additional, Narita, J., additional, Ishida, H., additional, Ishii, R., additional, Ueno, T., additional, and Miyagawa, S., additional
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- 2024
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9. Corrigendum to “Na(+)-dependent inactivation of vascular Na(+)/Ca(2+) exchanger responsible for reduced peripheral blood flow in neuropathic pain model” [Eur. J. Pharmacol. 910 (2021) 174448]
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Ishida, H., primary, Yamaguchi, M., additional, Saito, S.Y., additional, Furukawa, T., additional, Shannonhouse, J.L., additional, Kim, Y.S., additional, and Ishikawa, T., additional
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- 2024
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10. Automatic track recognition for large-angle minimum ionizing particles in nuclear emulsions
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Fukuda, T., Fukunaga, S., Ishida, H., Matsumoto, T., Matsuo, T., Mikado, S., Nishimura, S., Ogawa, S., Shibuya, H., Sudou, J., Ariga, A., and Tufanli, S.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
We previously developed an automatic track scanning system which enables the detection of large-angle nuclear fragments in the nuclear emulsion films of the OPERA experiment. As a next step, we have investigated this system's track recognition capability for large-angle minimum ionizing particles $(1.0 \leq |tan \theta| \leq 3.5)$. This paper shows that, for such tracks, the system has a detection efficiency of 95$\%$ or higher and reports the achieved angular accuracy of the automatically recognized tracks. This technology is of general purpose and will likely contribute not only to various analyses in the OPERA experiment, but also to future experiments, e.g. on low-energy neutrino and hadron interactions, or to future research on cosmic rays using nuclear emulsions carried by balloons., Comment: 11 pages, 10 figures, accepted by JINST
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- 2014
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11. Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial
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Arisaka, T, Asakura, T, Azuma, N, Fukuda, S, Fukushima, Y, Harada, N, Inoue, S, Ishida, H, Ishii, H, Ishikawa, S, Jinnouchi, H, Kaneko, S, Kanno, K, Kato, M, Kato, Y, Kawada, T, Kim, H, Kiyosue, A, Matsuoka, O, Miho, O, Nakamoto, S, Nakamura, S, Nakanishi, S, Nishimura, H, Numata, A, Ohama, T, Okabe, T, Okuguchi, F, Osonoi, T, Sasaki, T, Seino, H, Shin, K, Shiraiwa, T, Sugiura, T, Wada, S, Yamauchi, A, Yabe, Daisuke, Nakamura, Jiro, Kaneto, Hideaki, Deenadayalan, Srikanth, Navarria, Andrea, Gislum, Mette, and Inagaki, Nobuya
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- 2020
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12. Multidisciplinary treatment of pancreatic cancer with major arterial involvement in the US
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Franklin, O., primary, Stoop, T.F., additional, Sugawara, T., additional, Rodriguez Franco, S., additional, Ishida, H., additional, Schulick, R.D., additional, and Del Chiaro, M., additional
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- 2024
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13. EP08.03-03 S-1 and CDDP with Concurrent TRT Followed by Durvalumab in Elderly Population with Unresectable, LA-NSCLC in Japan: Post-hoc Analysis of SAMURAI
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Tanzawa, S., primary, Tanaka, H., additional, Inaba, M., additional, Nakamura, J., additional, Shibata, K., additional, Kishikawa, T., additional, Nakashima, M., additional, Fujiwara, K., additional, Kohyama, T., additional, Ishida, H., additional, Misumi, T., additional, Shiraishi, K., additional, Matsutani, N., additional, Seki, N., additional, and SAMURAI, G., additional
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- 2023
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14. Buried topological edge state associated with interface between topological band insulator and Mott insulator
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Ishida, H. and Liebsch, A.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The electronic structure at the interface between a topological band insulator and a Mott insulator is studied within layer dynamical mean field theory. To represent the bulk phases of these systems, we use the generalized Bernevig-Hughes-Zhang model that incorporates the Hubbard-like onsite Coulomb energy U in addition to the spin-orbit coupling term that causes band inversion. The topological and Mott insulating phases are realized by appropriately choosing smaller and larger values of U, respectively. As expected, the interface is found to be metallic because of the localized edge state. When the Coulomb energy in the Mott insulator is close to the critical value, however, this edge state exhibits its largest amplitude deep within the Mott insulator rather than at the interface. This finding corresponds to a new type of proximity effect induced by the neighboring topological band insulator and demonstrates that, as a result of spin-orbit coupling within the Mott insulator, several layers near the interface convert from the Mott insulating phase to a topological insulating phase. Moreover, we argue that the ordinary proximity effect, whereby a Kondo peak is induced in a Mott insulator by neighboring metallic states, is accompanied by an additional reverse proximity effect, by which the Kondo peak gives rise to an enhancement of the density of states in the neighboring metallic layer., Comment: 11 pages; 9 figures
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- 2014
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15. Observation of nu_tau appearance in the CNGS beam with the OPERA experiment
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OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Asada, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Buttne, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hayakawa, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Katsuragawa, T., Kawada, J., Kawahara, H., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malenica, M., Malgin, A., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Meyer, M., Mikado, S., Miyanishi, M., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Umemoto, A., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Yaguchi, I., Yoshimoto, M., Zemskova, S., and Zghiche, A.
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High Energy Physics - Experiment - Abstract
The OPERA experiment is searching for nu_mu -> nu_tau oscillations in appearance mode i.e. via the direct detection of tau leptons in nu_tau charged current interactions. The evidence of nu_mu -> nu_tau appearance has been previously reported with three nu_tau candidate events using a sub-sample of data from the 2008-2012 runs. We report here a fourth nu_tau candidate event, with the tau decaying into a hadron, found after adding the 2012 run events without any muon in the final state to the data sample. Given the number of analysed events and the low background, nu_mu -> nu_tau oscillations are established with a significance of 4.2sigma., Comment: Submitted to Progress of Theoretical and Experimental Physics (PTEP)
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- 2014
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16. Determination of the muon charge sign with the dipolar spectrometers of the OPERA experiment
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OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Goloubkov, D., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Meyer, M., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Rostovtseva, I., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zaitsev, Y., Zemskova, S., and Zghiche, A.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The OPERA long-baseline neutrino-oscillation experiment has observed the direct appearance of $\nu_\tau$ in the CNGS $\nu_\mu$ beam. Two large muon magnetic spectrometers are used to identify muons produced in the $\tau$ leptonic decay and in $\nu_\mu^{CC}$ interactions by measuring their charge and momentum. Besides the kinematic analysis of the $\tau$ decays, background resulting from the decay of charmed particles produced in $\nu_\mu^{CC}$ interactions is reduced by efficiently identifying the muon track. A new method for the charge sign determination has been applied, via a weighted angular matching of the straight track-segments reconstructed in the different parts of the dipole magnets. Results obtained for Monte Carlo and real data are presented. Comparison with a method where no matching is used shows a significant reduction of up to 40\% of the fraction of wrongly determined charges., Comment: 10 pages. Improvements in the text
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- 2014
17. Procedure for short-lived particle detection in the OPERA experiment and its application to charm decays
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Agafonova, N., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Buttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Gollnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zemskova, S., and Zghiche, A.
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High Energy Physics - Experiment - Abstract
The OPERA experiment, designed to perform the first observation of $\nu_\mu \rightarrow \nu_\tau$ oscillations in appearance mode through the detection of the $\tau$ leptons produced in $\nu_\tau$ charged current interactions, has collected data from 2008 to 2012. In the present paper, the procedure developed to detect $\tau$ particle decays, occurring over distances of the order of 1 mm from the neutrino interaction point, is described in detail. The results of its application to the search for charmed hadrons are then presented as a validation of the methods for $\nu_\tau$ appearance detection.
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- 2014
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18. Measurement of TeV atmospheric muon charge ratio with the full OPERA data
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Agafonova, N., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Buettner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zemskova, S., and Zghiche, A.
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High Energy Physics - Experiment - Abstract
The OPERA detector, designed to search for $\nu_{\mu} \to \nu_{\tau}$ oscillations in the CNGS beam, is located in the underground Gran Sasso laboratory, a privileged location to study TeV-scale cosmic rays. For the analysis here presented, the detector was used to measure the atmospheric muon charge ratio in the TeV region. OPERA collected charge-separated cosmic ray data between 2008 and 2012. More than 3 million atmospheric muon events were detected and reconstructed, among which about 110000 multiple muon bundles. The charge ratio $R_{\mu} \equiv N_{\mu^+}/N_{\mu^-}$ was measured separately for single and for multiple muon events. The analysis exploited the inversion of the magnet polarity which was performed on purpose during the 2012 Run. The combination of the two data sets with opposite magnet polarities allowed minimizing systematic uncertainties and reaching an accurate determination of the muon charge ratio. Data were fitted to obtain relevant parameters on the composition of primary cosmic rays and the associated kaon production in the forward fragmentation region. In the surface energy range 1-20 TeV investigated by OPERA, $R_{\mu}$ is well described by a parametric model including only pion and kaon contributions to the muon flux, showing no significant contribution of the prompt component. The energy independence supports the validity of Feynman scaling in the fragmentation region up to $200$ TeV/nucleon primary energy., Comment: 8 pages, 2 figures, 4 tables
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- 2014
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19. Evidence for $\nu_\mu \to \nu_\tau$ appearance in the CNGS neutrino beam with the OPERA experiment
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Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Asada, T., Autiero, D., Dhahbi, A. Ben, Badertscher, A., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Brunet, F., Brunetti, G., Buonaura, A., Buontempo, S., Buettner, B., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Favier, J., Ferber, T., Ferone, G., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Grianti, F., Guler, M., Gustavino, C., Hagner, C., Hakamata, K., Hara, T., Hayakawa, T., Hierholzer, M., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Ishikawa, M., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Katsuragawa, T., Kawada, J., Kawahara, H., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Migliozzi, P., Mikado, S., Miyanishi, M., Miyashita, E., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Rostovtseva, I., Rubbia, A., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt-Parzefal, W., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Suzuki, K., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Yoshida, J., Yoshimoto, M., Zaitsev, Y., Zemskova, S., and Zghiche, A.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
The OPERA experiment is designed to search for $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillations in appearance mode i.e. through the direct observation of the $\tau$ lepton in $\nu_{\tau}$ charged current interactions. The experiment has taken data for five years, since 2008, with the CERN Neutrino to Gran Sasso beam. Previously, two $\nu_{\tau}$ candidates with a $\tau$ decaying into hadrons were observed in a sub-sample of data of the 2008-2011 runs. Here we report the observation of a third $\nu_\tau$ candidate in the $\tau^-\to\mu^-$ decay channel coming from the analysis of a sub-sample of the 2012 run. Taking into account the estimated background, the absence of $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillations is excluded at the 3.4 $\sigma$ level., Comment: 9 pages, 5 figures, 1 tables
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- 2014
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20. GroundBIRD: A CMB Polarization Experiment with MKID Arrays
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Lee, K., Choi, J., Génova-Santos, R. T., Hattori, M., Hazumi, M., Honda, S., Ikemitsu, T., Ishida, H., Ishitsuka, H., Jo, Y., Karatsu, K., Kiuchi, K., Komine, J., Koyano, R., Kutsuma, H., Mima, S., Minowa, M., Moon, J., Nagai, M., Nagasaki, T., Naruse, M., Oguri, S., Otani, C., Peel, M., Rebolo, R., Rubiño-Martín, J. A., Sekimoto, Y., Suzuki, J., Taino, T., Tajima, O., Tomita, N., Uchida, T., Won, E., and Yoshida, M.
- Published
- 2020
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21. New results on $\nu_\mu \to \nu_\tau$ appearance with the OPERA experiment in the CNGS beam
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OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Asada, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Brunetti, G., Buettner, B., Buontempo, S., Chaussard, L., Chernyavskiy, M., Chiarella, V., Chukanov, A., Consiglio, L., D'Ambrosio, N., Sanchez, P. Del Amo, De Lellis, G., De Serio, M., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Ebert, J., Ereditato, A., Favier, J., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Grianti, F., Guler, A. M., Gustavino, C., Hagner, C., Hakamata, K., Hara, T., Hayakawa, T., Hierholzer, M., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Ishikawa, M., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Katsuragawa, T., Kawahara, H., Kawada, J., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Migliozzi, P., Mikado, S., Minotti, A., Miyanishi, M., Miyashita, E., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt-Parzefall, W., Shakiryanova, I., Schcedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Suzuki, K., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tolun, P., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Yoshida, J., Yoshimoto, M., Zaitsev, Y., Zemskova, S., and Zghiche, A.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
The OPERA neutrino experiment is designed to perform the first observation of neutrino oscillations in direct appearance mode in the $\nu_\mu \to \nu_\tau$ channel, via the detection of the $\tau$-leptons created in charged current $\nu_\tau$ interactions. The detector, located in the underground Gran Sasso Laboratory, consists of an emulsion/lead target with an average mass of about 1.2 kt, complemented by electronic detectors. It is exposed to the CERN Neutrinos to Gran Sasso beam, with a baseline of 730 km and a mean energy of 17 GeV. The observation of the first $\nu_\tau$ candidate event and the analysis of the 2008-2009 neutrino sample have been reported in previous publications. This work describes substantial improvements in the analysis and in the evaluation of the detection efficiencies and backgrounds using new simulation tools. The analysis is extended to a sub-sample of 2010 and 2011 data, resulting from an electronic detector-based pre-selection, in which an additional $\nu_\tau$ candidate has been observed. The significance of the two events in terms of a $\nu_\mu \to \nu_\tau$ oscillation signal is of 2.40 $\sigma$., Comment: 33 pages, 12 figures, 5 tables. Prepared for submission to JHEP
- Published
- 2013
22. Search for $\nu_\mu \rightarrow \nu_e$ oscillations with the OPERA experiment in the CNGS beam
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OPERA collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Bertolin, A., Bozza, C., Brugnera, R., Brunet, F., Brunetti, G., Buettner, B., Buontempo, S., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievsky, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Grianti, F., Guler, A. M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Hierholzer, M., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Juget, F., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Mancini-Terracciano, C., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meisel, F. W., Meregaglia, A., Migliozzi, P., Mikado, S., Minotti, A., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Nakamura, M., Nakano, T., Nakatsuka, Y., Naumov, D., Niwa, K., Ogawa, S., Okateva, N., Olchevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryazhskaya, O., Sato, O., Sato, Y., Schchedrina, T., Schembri, A., Schmidt-Parzefall, W., Shakiryanova, I., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Suzuki, K., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tolun, P., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. -L., Wilquet, G., Wonsak, B., Yoon, C. S., Yoshida, J., Zaitsev, Y., Zemskova, S., and Zghiche, A.
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High Energy Physics - Experiment - Abstract
A first result of the search for \numu $\rightarrow$ \nue oscillations in the OPERA experiment, located at the Gran Sasso Underground Laboratory, is presented. The experiment looked for the appearance of \nue in the CNGS neutrino beam using the data collected in 2008 and 2009. Data are compatible with the non-oscillation hypothesis in the three-flavour mixing model. A further analysis of the same data constrains the non-standard oscillation parameters $\theta_{new}$ and $\Delta m^2_{new}$ suggested by the LSND and MiniBooNE experiments. For large $\Delta m^{2}_{new}$ values ($>$0.1 eV$^{2}$), the OPERA 90% C.L. upper limit on sin$^{2}(2\theta_{new})$ based on a Bayesian statistical method reaches the value $7.2 \times 10^{-3}$.
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- 2013
23. Automatic scanning of nuclear emulsions with wide-angle acceptance for nuclear fragment detection
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Fukuda, T., Fukunaga, S., Ishida, H., Kodama, K., Matsuo, T., Mikado, S., Ogawa, S., Shibuya, H., and Sudo, J.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
Nuclear emulsion, a tracking detector with sub-micron position resolution, has played a successful role in the field of particle physics and the analysis speed has been substantially improved by the development of automated scanning systems. This paper describes a newly developed automated scanning system and its application to the analysis of nuclear fragments emitted almost isotropically in nuclear evaporation. This system is able to recognize tracks of nuclear fragments up to |tan{\theta}|< 3.0 (where {\theta} is the track angle with respect to the perpendicular to the emulsion film), while existing systems have an angular acceptance limited to |tan{\theta}|< 0.6. The automatic scanning for such a large angle track in nuclear emulsion is the first trial. Furthermore the track recognition algorithm is performed by a powerful Graphics Processing Unit (GPU) for the first time. This GPU has a sufficient computing power to process large area scanning data with a wide angular acceptance and enough flexibility to allow the tuning of the recognition algorithm. This new system will in particular be applied in the framework of the OPERA experiment : the background in the sample of tau decay candidates due to hadronic interactions will be reduced by a better detection of the emitted nuclear fragments., Comment: 12 pages, 12 figures, accepted by JINST
- Published
- 2013
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24. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam using the 2012 dedicated data
- Author
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The OPERA Collaboration, Adam, T., Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Beretta, M., Bertolin, A., Bozza, C., Brugière, T., Brugnera, R., Brunet, F., Brunetti, G., Buettner, B., Buontempo, S., Carlus, B., Cavanna, F., Cazes, A., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievsky, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Esposito, L. S., Favier, J., Felici, G., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Girerd, C., Goellnitz, C., Goldberg, J., Golubkov, D., Gornushkin, Y., Grella, G., Grianti, F., Guerin, C., Guler, A. M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Hierholzer, M., Hollnagel, A., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lazzaro, C., Lenkeit, J., Ljubicic, A., Longhin, A., Mancini-Terracciano, C., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Migliozzi, P., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Moser, U., Muciaccia, M. T., Nakamura, M., Nakano, T., Nakatsuka, Y., Naumov, D., Nikitina, V., Ogawa, S., Olchevsky, A., Ozaki, K., Palamara, O., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt-Parzefall, W., Schuler, J., Shakiryanova, I., Sheshukov, A., Shibuya, H., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Song, J. S., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tolun, P., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Wurtz, J., Yoon, C. S., Yoshida, J., Zaitsev, Y., Zemskova, S., Zghiche, A., and Zimmermann, R.
- Subjects
High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
In spring 2012 CERN provided two weeks of a short bunch proton beam dedicated to the neutrino velocity measurement over a distance of 730 km. The OPERA neutrino experiment at the underground Gran Sasso Laboratory used an upgraded setup compared to the 2011 measurements, improving the measurement time accuracy. An independent timing system based on the Resistive Plate Chambers was exploited providing a time accuracy of $\sim$1 ns. Neutrino and anti-neutrino contributions were separated using the information provided by the OPERA magnetic spectrometers. The new analysis profited from the precision geodesy measurements of the neutrino baseline and of the CNGS/LNGS clock synchronization. The neutrino arrival time with respect to the one computed assuming the speed of light in vacuum is found to be $\delta t_\nu \equiv TOF_c - TOF_\nu= (0.6 \pm 0.4\ (stat.) \pm 3.0\ (syst.))$ ns and $\delta t_{\bar{\nu}} \equiv TOF_c - TOF_{\bar{\nu}} = (1.7 \pm 1.4\ (stat.) \pm 3.1\ (syst.))$ ns for $\nu_{\mu}$ and $\bar{\nu}_{\mu}$, respectively. This corresponds to a limit on the muon neutrino velocity with respect to the speed of light of $-1.8 \times 10^{-6} < (v_{\nu}-c)/c < 2.3 \times 10^{-6}$ at 90% C.L. This new measurement confirms with higher accuracy the revised OPERA result., Comment: 14 pages, 4 figures
- Published
- 2012
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25. A new method to correct deformations in emulsion using a precise photomask
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Kimura, M., Ishida, H., Shibuya, H., Ogawa, S., Matsuo, T., Fukushima, C., Takahashi, G., Kuge, K., Sato, Y., Tezuka, I., and Mikado, S.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
A new method to correct the emulsion deformation, mainly produced in the development process, is developed to recover the high accuracy of nuclear emulsion as a tracking device. The method is based on a precise photomask and a careful treatment of the emulsion films. A position measurement accuracy of 0.6 {\mu}m is obtained over an area of 5 cm x 7 cm. The method allows to measure positions of track segments with submicron accuracy in an ECC brick with as few as 10 reference tracks for alignment. Such a performance can be important for hybrid emulsion experiments at underground laboratories where only a small number of reference tracks for alignment are available., Comment: 19 pages, 10 figures
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- 2012
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26. Coulomb blockade and Kondo effect in the electronic structure of Hubbard molecules connected to metallic leads: a finite-temperature exact-diagonalization study
- Author
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Ishida, H. and Liebsch, A.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
The electronic structure of small Hubbard molecules coupled between two non-interacting semi-infinite leads is studied in the low bias-voltage limit. To calculate the finite-temperature Green's function of the system, each lead is simulated by a small cluster, so that the problem is reduced to that of a finite-size system comprising the molecule and clusters on both sides. The Hamiltonian parameters of the lead clusters are chosen such that their embedding potentials coincide with those of the semi-infinite leads on Matsubara frequencies. Exact diagonalization is used to evaluate the effect of Coulomb correlations on the electronic properties of the molecule at finite temperature. Depending on key Hamiltonian parameters, such as Coulomb repulsion, one-electron hopping within the molecule, and hybridization between molecule and leads, the molecular self-energy is shown to exhibit Fermi-liquid behavior or deviations associated with finite low-energy scattering rates. The method is shown to be sufficiently accurate to describe the formation of Kondo resonances inside the correlation-induced pseudogaps, except in the limit of extremely low temperatures. These results demonstrate how the system can be tuned between the Coulomb blockade and Kondo regimes., Comment: 14 pages; 14 figures
- Published
- 2012
- Full Text
- View/download PDF
27. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam
- Author
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The OPERA Collaboration, Adam, T., Agafonova, N., Aleksandrov, A., Altinok, O., Sanchez, P. Alvarez, Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Bertolin, A., Bozza, C., Brugiere, T., Brugnera, R., Brunet, F., Brunetti, G., Buontempo, S., Carlus, B., Cavanna, F., Cazes, A., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., Colosimo, G., Crespi, M., D'Ambrosio, N., De Lellis, G., De Serio, M., Declais, Y., Sanchez, P. del Amo, Di Capua, F., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievsky, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Efthymiopoulos, I., Egorov, O., Ereditato, A., Esposito, L. S., Favier, J., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Giorgini, M., Giovannozzi, M., Girerd, C., Goldberg, J., Gollnitz, C., Golubkov, D., Goncharova, L., Gornushkin, Y., Grella, G., Grianti, F., Gschwendtner, E., Guerin, C., Guler, A. M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Enikeev, R., Hierholzer, M., Hollnagel, A., Ieva, M., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Jones, M., Juget, F., Kamiscioglu, M., Kawada, J., Kim, S. H., Kimura, M., Kiritsis, E., Kitagawa, N., Klicek, B., Knuesel, J., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lazzaro, C., Lenkeit, J., Ljubicic, A., Longhin, A., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Mazzoni, A., Medinaceli, E., Meisel, F., Meregaglia, A., Migliozzi, P., Mikado, S., Missiaen, D., Monacelli, P., Morishima, K., Moser, U., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Naumov, D., Nikitina, V., Nitti, F., Ogawa, S., Okateva, N., Olchevsky, A., Palamara, O., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Riguzzi, F., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryasny, V., Ryazhskaya, O., Sato, O., Sato, Y., Sahnoun, Z., Schembri, A., Schuler, J., Lavina, L. Scotto, Serrano, J., Shakiryanova, I., Sheshukov, A., Shibuya, H., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Song, J. S., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S., Stipcevic, M., Strauss, T., Takahashi, S., Tenti, M., Terranova, F., Tezuka, I., Tioukov, V., Tolun, P., Tran, N. T., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. -L., Wilquet, G., Wonsak, B., Wurtz, J., Yakushev, V., Yoon, C. S., Yoshida, J., Zaitsev, Y., Zemskova, S., and Zghiche, A.
- Subjects
High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The OPERA neutrino experiment at the underground Gran Sasso Laboratory has measured the velocity of neutrinos from the CERN CNGS beam over a baseline of about 730 km. The measurement is based on data taken by OPERA in the years 2009, 2010 and 2011. Dedicated upgrades of the CNGS timing system and of the OPERA detector, as well as a high precision geodesy campaign for the measurement of the neutrino baseline, allowed reaching comparable systematic and statistical accuracies. An arrival time of CNGS muon neutrinos with respect to the one computed assuming the speed of light in vacuum of (6.5 +/- 7.4(stat.)((+8.3)(-8.0)sys.))ns was measured corresponding to a relative difference of the muon neutrino velocity with respect to the speed of light (v-c)/c =(2.7 +/-3.1(stat.)((+3.4)(-3.3)(sys.))x10^(-6). The above result, obtained by comparing the time distributions of neutrino interactions and of protons hitting the CNGS target in 10.5 microseconds long extractions, was confirmed by a test performed at the end of 2011 using a short bunch beam allowing to measure the neutrino time of flight at the single interaction level., Comment: 34 pages, 22 figures This version replaces all previous ones
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- 2011
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28. Correlation induced spin freezing transition in FeSe: a dynamical mean field study
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Liebsch, A. and Ishida, H.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
The effect of local Coulomb interactions on the electronic properties of FeSe is explored within dynamical mean field theory combined with finite-temperature exact diagonalization. The low-energy scattering rate is shown to exhibit non-Fermi-liquid behavior caused by the formation of local moments. Fermi-liquid properties are restored at large electron doping. In contrast, FeAsLaO is shown to be located on the Fermi-liquid side of this spin freezing transition., Comment: 4 pages, 5 figures
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- 2010
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29. Mott transition in two-dimensional frustrated compounds
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Liebsch, A., Ishida, H., and Merino, J.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The phase diagrams of isotropic and anisotropic triangular lattices with local Coulomb interactions are evaluated within cluster dynamical mean field theory. As a result of partial geometric frustration in the anisotropic lattice, short range correlations are shown to give rise to reentrant behavior which is absent in the fully frustrated isotropic limit. The qualitative features of the phase diagrams including the critical temperatures are in good agreement with experimental data for the layered organic charge transfer salts kappa-(BEDT-TTF)_2Cu[N(CN)_2]Cl and kappa-(BEDT-TTF)_2Cu_2(CN)_3., Comment: 4 pages, 4 figures
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- 2009
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30. Competing role of the p and d orbitals in the orbital angular momentum induced spin splitting of surface states on Au(110)
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Ishida, H., primary
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- 2023
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31. Health economic evaluation of peritoneal dialysis based on cost-effectiveness in Japan: a preliminary study
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Takura T, Hiramatsu M, Nakamoto H, Kuragano T, Minakuchi J, Ishida H, Nakayama M, Takahashi S, and Kawanishi H
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diabetic nephropathy ,cost-utility analysis ,quality-adjusted life year ,medical service reimbursement ,automated peritoneal dialysis ,propensity score ,Medicine (General) ,R5-920 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Tomoyuki Takura,1 Makoto Hiramatsu,2 Hidetomo Nakamoto,3 Takahiro Kuragano,4 Jun Minakuchi,5 Hironori Ishida,6 Masaaki Nakayama,7 Susumu Takahashi,8 Hideki Kawanishi9 1Department of Health Economy and Society Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 2Outpatient Center Hospital, Okayama Saiseikai General Hospital, Okayama City, Okayama, Japan; 3General Intrarenal Medicine, Saitama Medical University, Saitama, Japan; 4Internal Medicine (Nephrology and Dialysis), Hyogo College of Medicine, Nishinomiya City, Hyogo, Japan; 5Nephrology (Endocrinology), Kawashima Hospital, Tokushima City, Tokushima, Japan; 6Urology, Kitasaito Hospital, Asahikawa City, Hokaido, Japan; 7Kidney Center, St. Luke’s International Hospital, Tokyo, Japan; 8Head Office, International Kidney Evaluation Association Japan, Tokyo, Japan; 9Artificial Organs and Surgery, Tsuchiya General Hospital, Hiroshima City, Hiroshima, JapanCorrespondence: Tomoyuki TakuraDepartment of Health Economy and Society Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanTel +81 35 800 9523Fax +81 35 800 9156Email ttakura@m.u-tokyo.ac.jpBackground: In Japan, the medical expenditures associated with dialysis have garnered considerable interest; however, a cost-effectiveness evaluation of peritoneal dialysis (PD) is yet to be evaluated. In particular, the health economics of the “PD first” concept, which can be advantageous for clinical practice and healthcare systems, must be evaluated.Methods: This multicenter study investigated the cost-effectiveness of PD. The major effectiveness indicator was quality-adjusted life year (QALY), with a preference-based utility value based on renal function, and the cost indicator was the amount billed for a medical service at each medical institution for qualifying illnesses. In comparison with hemodialysis (HD), a baseline analysis of PD therapy was conducted using a cost-utility analysis (CUA). Continuous ambulatory PD (CAPD) and automated PD (APD) were compared based on the incremental cost-utility ratio (ICUR) and propensity score (PS) with a limited number of cases.Results: The mean duration since the start of PD was 35.0±14.4 months. The overall CUA for PD (179 patients) was USD 55,019/QALY, which was more cost effective (USD/monthly utility) compared with that for HD for 12–24 months (4,367 vs. 4,852; p
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- 2019
32. Embedding approach for dynamical mean field theory of strongly correlated heterostructures
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Ishida, H. and Liebsch, A.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We present an embedding approach based on localized basis functions which permits an efficient application of the dynamical mean field theory (DMFT) to inhomogeneous correlated materials, such as semi-infinite surfaces and heterostructures. In this scheme, the semi-infinite substrate leads connected to both sides of the central region of interest are represented via complex, energy-dependent embedding potentials that incorporate one-electron as well as many-body effects within the substrates. As a result, the number of layers which must be treated explicitly in the layer-coupled DMFT equation is greatly reduced. To illustrate the usefulness of this approach, we present numerical results for strongly correlated surfaces, interfaces, and heterostructures of the single-band Hubbard model., Comment: 8 pages, 4 figures; typos corrected
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- 2008
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33. Multisite versus multiorbital Coulomb correlations studied within finite-temperature exact diagonalization dynamical mean-field theory
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Liebsch, A., Ishida, H., and Merino, J.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The influence of short-range Coulomb correlations on the Mott transition in the single-band Hubbard model at half-filling is studied within cellular dynamical mean field theory for square and triangular lattices. Finite-temperature exact diagonalization is used to investigate correlations within two-, three-, and four-site clusters. Transforming the non-local self-energy from a site basis to a molecular orbital basis, we focus on the inter-orbital charge transfer between these cluster molecular orbitals in the vicinity of the Mott transition. In all cases studied, the charge transfer is found to be small, indicating weak Coulomb induced orbital polarization despite sizable level splitting between orbitals. These results demonstrate that all cluster molecular orbitals take part in the Mott transition and that the insulating gap opens simultaneously across the entire Fermi surface. Thus, at half-filling we do not find orbital-selective Mott transitions, nor a combination of band filling and Mott transition in different orbitals. Nevertheless, the approach towards the transition differs greatly between cluster orbitals, giving rise to a pronounced momentum variation along the Fermi surface, in agreement with previous works. The near absence of Coulomb induced orbital polarization in these clusters differs qualitatively from single-site multi-orbital studies of several transition metal oxides, where the Mott phase exhibits nearly complete orbital polarization as a result of a correlation driven enhancement of the crystal field splitting. The strong single-particle coupling among cluster orbitals in the single-band case is identified as the source of this difference., Comment: 12 pages, 10 figures
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- 2008
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34. Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice
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Sobajima A, Haniu H, Nomura H, Tanaka M, Takizawa T, Kamanaka T, Aoki K, Okamoto M, Yoshida K, Sasaki J, Ajima K, Kuroda C, Ishida H, Okano S, Ueda K, Kato H, and Saito N
- Subjects
multiwalled carbon nanotubes ,rasH2 transgenic mouse ,carcinogenicity ,organ accumulation ,dispersion ,Medicine (General) ,R5-920 - Abstract
Atsushi Sobajima,1 Hisao Haniu,1,2 Hiroki Nomura,1 Manabu Tanaka,1 Takashi Takizawa,1 Takayuki Kamanaka,1 Kaoru Aoki,1,3 Masanori Okamoto,1 Kazushige Yoshida,1 Jun Sasaki,1 Kumiko Ajima,2 Chika Kuroda,1,2 Haruka Ishida,2 Satomi Okano,2 Katsuya Ueda,2 Hiroyuki Kato,1 Naoto Saito1,21Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 2Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 3Department of Applied Physical Therapy, Shinshu University School of Health Sciences, Matsumoto, Nagano, JapanPurpose: Multiwalled carbon nanotubes (MWCNTs) have been known to enter the circulatory system via the lungs from inhalation exposure; however, its carcinogenicity and subsequent accumulation in other organs have not been adequately reported in the literature. Moreover, the safety of MWCNTs as a biomaterial has remained a matter of debate, particularly when the material enters the circulatory system. To address these problems, we used carcinogenic rasH2 transgenic mice to intravenously administer highly dispersed MWCNTs and to evaluate their carcinogenicity and accumulation in the organs.Methods: Two types of MWCNTs (thin- and thick-MWCNTs) were intravenously administered at a high dose (approximately 0.7 mg per kg body weight) and low dose (approximately 0.07 mg per kg body weight).Results: MWCNTs showed pancreatic accumulation in 3.2% of mice administered with MWCNTs, but there was no accumulation in other organs. In addition, there was no significant difference in the incidence of tumor among the four MWCNTs-administered groups compared to the vehicle group without MWCNTs administration. Blood tests revealed elevated levels in mean red blood cell volume and mean red blood cell hemoglobin level for the MWCNTs-administered group, in addition to an increase in eotaxin.Conclusion: The present study demonstrated that the use of current technology to sufficiently disperse MWCNTs resulted in minimal organ accumulation with no evidence of carcinogenicity.Keywords: multiwalled carbon nanotubes, rasH2 transgenic mouse, carcinogenicity, organ accumulation, dispersion
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- 2019
35. Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
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Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Okano S, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Kito M, Aoki K, Uemura T, Haniu H, Kato H, and Saito N
- Subjects
anti-PD-1 antibody ,perforin ,granzyme B ,IFNγ ,osteosarcoma ,clinical outcome ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Kazushige Yoshida,1 Masanori Okamoto,1 Jun Sasaki,1 Chika Kuroda,2 Haruka Ishida,2 Katsuya Ueda,2 Satomi Okano,2 Hirokazu Ideta,1 Takayuki Kamanaka,1 Atsushi Sobajima,1 Takashi Takizawa,1 Munehisa Kito,1 Kaoru Aoki,3 Takeshi Uemura,2 Hisao Haniu,2 Hiroyuki Kato,1 Naoto Saito2 1Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan; 2Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto, Japan; 3Physical Therapy Division, School of Health Sciences, Shinshu University School of Medicine, Matsumoto, Japan Purpose: Although both anti-PD-1 antibody and treatments using anti-PD-L1 antibody are currently in clinical use, their therapeutic effects vary according to cancer type. One of the factors accounting for this variability is the expression level of the immune checkpoint molecule that differs between cancer types; thus, it is important to clarify the relationship between clinical outcomes and immune checkpoint molecules for all types of human cancer. The purpose of this study is to evaluate the clinical outcome of osteosarcoma in relation to PD-L1, PRF, GZMB, and IFNγ expression. Methods: Using 19 clinical specimens of osteosarcoma, we examined the expression of PD-L1, PRF, GZMB, and IFNγ in relation to their clinical outcomes. Results: PD-L1 expression correlated with early metastatic formation in clinical specimens of osteosarcoma, and the group with highly expressed functional markers for T cells such as PRF and GZMB resulted in a long overall survival time. Conclusion: This is the first study to elucidate the clinical outcomes of osteosarcoma in relation to PD-L1, PRF, GZMB, and IFNγ expression. This study provides valuable information regarding the clinical indication and prediction of effect for anti-PD-1 antibody in osteosarcoma. Keywords: anti-PD-1 antibody, perforin, granzyme B, IFNγ, osteosarcoma, clinical outcome
- Published
- 2019
36. The Study of Fiber-Matrix Interactions Via FT-IR Microscopy and NMR Imaging *
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Mavrich, A., primary, Fondeur, F., additional, Ishida, H., additional, Koenig, J. L., additional, and Wagner, H. D., additional
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- 2020
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37. The Mott insulator LaTiO_3 in heterostructures with SrTiO_3 is metallic
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Ishida, H. and Liebsch, A.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
It is shown that LaTiO_3 in superlattices with SrTiO_3 is not a Mott insulator but a strongly correlated metal. The tetragonal lattice geometry imposed by the SrTiO_3 substrate leads to an increase of the Ti 3d t2g band width and a reversal of the t2g crystal field relative to the orthorhombic bulk geometry. Using dynamical mean field theory based on finite-temperature multi-band exact diagonalization we show that, as a result of these effects, local Coulomb interactions are not strong enough to induce a Mott transition in tetragonal LaTiO_3. The metalicity of these heterostructures is therefore not an interface property but stems from all LaTiO_3 planes., Comment: 4 pages, 4 figures
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- 2007
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38. Coulomb correlations do not fill the e'_g hole pockets in Na_{0.3}CoO_2
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Liebsch, A. and Ishida, H.
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Condensed Matter - Strongly Correlated Electrons - Abstract
There exists presently considerable debate over the question whether local Coulomb interactions can explain the absence of the small e'_g Fermi surface hole pockets in photoemission studies of Na_{0.3}CoO_2. By comparing dynamical mean field results for different single particle Hamiltonians and exact diagonalization as well as quantum Monte Carlo treatments, we show that, for realistic values of the Coulomb energy U and Hund exchange J, the e'_g pockets can be slightly enhanced or reduced compared to band structure predictions, but they do not disappear., Comment: 4 pages, 2 figures
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- 2007
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39. Subband filling and Mott transition in Ca_{2-x}Sr_xRuO_4
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Liebsch, A. and Ishida, H.
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Condensed Matter - Strongly Correlated Electrons - Abstract
A new concept is proposed for the paramagnetic metal insulator transition in the layer perovskite Ca_{2-x}Sr_xRuO_4. Whereas the pure Sr compound is metallic up to very large Coulomb energies due to strong orbital fluctuations, structural changes induced by doping with Ca give rise to a interorbital charge transfer which makes the material extremely sensitive to local correlations. Using dynamical mean field theory based on finite temperature multi-band exact diagonalization it is shown that the combination of crystal field splitting and onsite Coulomb interactions leads to complete filling of the d_xy band and to a Mott transition in the half-filled d_xz,yz bands., Comment: 4 pages, 3 figures
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- 2006
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40. Exact Diagonalization Dynamical Mean Field Theory for Multi-Band Materials: Effect of Coulomb correlations on the Fermi surface of Na_0.3CoO_2
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Perroni, C. A., Ishida, H., and Liebsch, A.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Dynamical mean field theory combined with finite-temperature exact diagonalization is shown to be a suitable method to study local Coulomb correlations in realistic multi-band materials. By making use of the sparseness of the impurity Hamiltonian, exact eigenstates can be evaluated for significantly larger clusters than in schemes based on full diagonalization. Since finite-size effects are greatly reduced this approach allows the study of three-band systems down to very low temperatures, for strong local Coulomb interactions and full Hund exchange. It is also shown that exact diagonalization yields smooth subband quasi-particle spectra and self-energies at real frequencies. As a first application the correlation induced charge transfer between t2g bands in Na_0.3CoO_2 is investigated. For both Hund and Ising exchange the small eg' Fermi surface hole pockets are found to be slightly enlarged compared to the non-interacting limit, in agreement with previous Quantum Monte Carlo dynamical mean field calculations for Ising exchange, but in conflict with photoemission data., Comment: 9 pages, 7 figures
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- 2006
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41. Effect of Dynamical Coulomb Correlations on the Fermi Surface of Na_0.3CoO_2
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Ishida, H., Johannes, M. D., and Liebsch, A.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The t2g quasi-particle spectra of Na_0.3CoO_2 are calculated within the dynamical mean field theory. It is shown that as a result of dynamical Coulomb correlations charge is transfered from the nearly filled e_g' subbands to the a_1g band, thereby reducing orbital polarization among Co t2g states. Dynamical correlations therefore stabilize the small e_g' Fermi surface pockets, in contrast to angle-resolved photoemission data, which do not reveal these pockets., Comment: 4 pages, to appear in PRL
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- 2004
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42. Spin Fluctuation and Crystal Field Excitation of a Heavy Fermion Compound YbAgGe studied by Inelastic Neutron Scattering
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Matsumura, T., Ishida, H., Satoh, T. J., Katoh, K., Niide, Y., and Ochiai, A.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Inelastic neutron scattering experiment has been performed on a new heavy fermion compound YbAgGe for a polycrystalline sample at zero magnetic field. A quasielastic scattering and a crystal field excitation at 12 meV was observed. Both of them are broadened with an intrinsic width of 0.9 meV at 1.5 K which increases to about 3 meV at 300 K. The temperature dependence follows Gamma_0+AT^(1/2) typically observed in Kondo systems. Crystal field parameters were also deduced. To explain the result that only one excitation isobserved at 12 meV, it is concluded that the B22 term should be the main component., Comment: 4pages, submitted to JPSJ
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- 2004
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43. An embedding potential definition of channel functions
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Inglesfield, J E, Crampin, S, and Ishida, H
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Mathematical Physics - Abstract
We show that the imaginary part of the embedding potential, a generalised logarithmic derivative, defined over the interface between an electrical lead and some conductor, has orthogonal eigenfunctions which define conduction channels into and out of the lead. In the case of an infinitely extended interface we establish the relationship between these eigenfunctions and the Bloch states evaluated over the interface. Using the new channel functions, a well-known result for the total transmission through the conductor system is simply derived., Comment: 14 pages, 2 figures
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- 2004
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44. Coulomb Correlations and Orbital Polarization in the Metal Insulator Transition of VO_2
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Liebsch, A., Ishida, H., and Bihlmayer, G.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The quasi-particle spectra in the metallic rutile and insulating monoclinic phases of VO$_2$ are shown to be dominated by local Coulomb interactions. In the rutile phase the small orbital polarization among V 3d t_2g states leads to weak static but strong dynamical correlations. In the monoclinic phase the large 3d orbital polarization caused by the V--V Peierls distortion gives rise to strong static correlations which are shown to be the primary cause of the insulating behavior., Comment: 5 pages, replaces cond-mat/0310216
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- 2003
45. Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells
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Kuroda C, Ueda K, Haniu H, Ishida H, Okano S, Takizawa T, Sobajima A, Kamanaka T, Yoshida K, Okamoto M, Tsukahara T, Matsuda Y, Aoki K, Kato H, and Saito N
- Subjects
multiwalled carbon nanotubes ,aggregation ,carbon nanohorns ,cytotoxicity ,immune response ,cellular uptake ,Medicine (General) ,R5-920 - Abstract
Chika Kuroda,1,2,* Katsuya Ueda,1,3,* Hisao Haniu,1,3–5 Haruka Ishida,1,4 Satomi Okano,1,4 Takashi Takizawa,5 Atsushi Sobajima,5 Takayuki Kamanaka,5 Kazushige Yoshida,5 Masanori Okamoto,5 Tamotsu Tsukahara,6 Yoshikazu Matsuda,7 Kaoru Aoki,8 Hiroyuki Kato,5 Naoto Saito1,3–5 1Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Asahi, Matsumoto, Nagano, Japan; 2Department of Orthopaedic Surgery, Graduate School of Medicine, Shinshu University, Asahi, Matsumoto, Nagano, Japan; 3Department of Biomedical Engineering, Graduate School of Science and Technology, Shinshu University, Asahi, Matsumoto, Nagano, Japan; 4Department of Biomedical Engineering, Graduate School of Medicine, Science and Technology, Shinshu University, Asahi, Matsumoto, Nagano, Japan; 5Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan; 6Department of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Bunkyo-machi, Nagasaki, Japan; 7Clinical Pharmacology Educational Center, Nihon Pharmaceutical University, Komuro, Ina-machi, Saitama, Japan; 8Physical Therapy Division, School of Health Sciences, Shinshu University, Asahi, Matsumoto, Nagano, Japan *These authors contributed equally to this work Introduction: Carbon nanotubes (CNTs) have various shapes, including needle-like shapes and curled shapes, and the cytotoxicity and carcinogenicity of CNTs differ depending on their shapes and surface modifications. However, the biological responses induced by CNTs and related mechanisms according to the dispersion state of CNTs have not been extensively studied.Materials and methods: We prepared multiwalled CNTs (MWCNTs) showing different dispersions and evaluated these MWCNTs in RAW264 cells to determine cytotoxicity, cellular uptake, and immune responses. Furthermore, RAW264 cells were also used to compare the cellular uptake and cytotoxicity of fibrous MWCNTs and spherical carbon nanohorns (CNHs) exhibiting the same degree of dispersion.Results: Our analysis showed that the cellular uptake, localization, and inflammatory responses of MWCNTs differed depending on the dispersion state. Moreover, there were differences in uptake between MWCNTs and CNHs, even showing the same degree of dispersion. These findings suggested that receptors related to cytotoxicity and immune responses differed depending on the aggregated state of MWCNTs and surface modification with a dispersant. Furthermore, our results suggested that the receptors recognized by the cells differed depending on the particle shape.Conclusion: Therefore, to apply MWCNTs as a biomaterial, it is important to determine the carcinogenicity and toxicity of the CNTs and to examine different biological responses induced by varying shapes, dispersion states, and surface modifications of particles. Keywords: multiwalled carbon nanotubes, aggregation, carbon nanohorns, cytotoxicity, immune response, cellular uptake
- Published
- 2018
46. 1085 Crisaborole inhibits itch and pain by preventing neutrophil infiltration
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Pavlenko, D., primary, Seven, Z. G. Todurga, additional, Bystrom, L.L., additional, Markan, A., additional, Ishida, H., additional, and Akiyama, T., additional
- Published
- 2023
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47. A sting in the tail: An embedded stingray spine in a mid-1st millennium AD adult male skeleton from Rebun Island, Hokkaido, Japan
- Author
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Schulting, R, Kubo, D, Nishida, K, Braddick, I, Yoneda, M, Kato, H, and Ishida, H
- Subjects
Adult ,Male ,Archeology ,Archaeology ,Japan ,Radiometric Dating ,Animals ,Humans ,Skates, Fish ,Bone and Bones ,Pathology and Forensic Medicine - Abstract
Objectives We report here a stingray spine (Dasyatidae) found embedded in the femur of a male skeleton from the archaeological site of Uedomari-5, Rebun Island, Hokkaido, Japan. Materials A single well-preserved but incomplete human skeleton. Methods Macroscopic observation and low power magnification, CT imaging, radiocarbon dating and stable isotope (carbon, nitrogen) analysis. Results The stingray spine is tentatively identified as Bathytoshia brevicaudata. CT imaging shows no healing, indicating that death occurred shortly afterwards. The skeleton has been directly radiocarbon dated to the Okhotsk period (cal AD 429–827), with δ13C (−13.7‰) and δ15N (19.3‰) values indicating a diet focused on marine foods. Conclusions The absence of healing in what would have been a non-lethal injury strongly suggests that the spine tipped an arrowhead, rather than being the result of an accidental encounter with a living stingray. It is possible that the injury reflects a period of increased conflict coinciding with, or following on from, the expansion of the Okhotsk culture from Sakhalin into northern Hokkaido. Significance Uedomari-5 provides the first example, to our knowledge, of a stingray spine directly embedded in human bone at an archaeological site. More widely, the finding contributes to our knowledge of conflict in northern hunter-gatherer communities. Limitations Given the early excavation date (1949–50), there is little contextual information available for the burials. Suggestions for further research ZooMS (Zooarchaeology by Mass Spectrometry) may be able to identify the stingray species. Archival research may provide more information concerning the excavations at Uedomari-5.
- Published
- 2022
48. Efficacy of everolimus in ABO-incompatible kidney transplantation: a retrospective study
- Author
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Tsujimura K, Ota M, Chinen K, Nagayama K, Oroku M, Nishihira M, Shiohira Y, Iseki K, Ishida H, and Tanabe K
- Subjects
Blood Group Incompatibility ,Immunosuppression ,Kidney Transplantation ,Medicine (General) ,R5-920 - Abstract
Kazuma Tsujimura,1 Morihito Ota,1 Kiyoshi Chinen,1 Kiyomitsu Nagayama,2 Masato Oroku,2 Morikuni Nishihira,2 Yoshiki Shiohira,2 Kunitoshi Iseki,3 Hideki Ishida,4 Kazunari Tanabe4 1Department of Surgery, 2Department of Nephrology, 3Clinical Research Support Center, Tomishiro Central Hospital, Okinawa, Japan; 4Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan Background: There are limited reports on the use of everolimus for maintaining immunosuppression in ABO-incompatible (ABOi) kidney transplantation (KT). As everolimus (EVR) is effective for preventing calcineurin inhibitor (CNI) nephrotoxicity without increasing the risk of chronic rejection and viral infection, we aimed to assess the efficacy of EVR in ABOi KT.Patients and methods: We retrospectively studied 22 patients who underwent KT and received EVR. Patients in the ABOi KT group (n=7) were compared with those in the ABO-compatible kidney transplantation group (ABOc KT; n=15). We recorded the frequency of CNI nephrotoxicity, chronic rejection, and viral infection in the 2 groups.Results: CNI nephrotoxicity, chronic rejection, and viral infection occurred in the ABOi KT and ANOc KT groups at rates of 28.3% (2/7 patients) and 13.3% (2/15 patients) (P=0.388), 28.3% (2/7 patients) and 26.7% (4/15 patients) (P=0.926), and 14.3% (1/7 patients) and 26.7% (4/15 patients) (P=0.517), respectively.Conclusion: Administration of EVR is effective in preventing CNI nephrotoxicity after KT. The rate of CNI nephrotoxicity was lower in the ABOc KT group than in the ABOi KT group. The rate of chronic rejection and viral infection was comparable between the groups. This study was conducted in a small cohort of patients. Hence, further evaluation with large sample sizes is necessary in the future to confirm the outcomes. Keywords: blood group incompatibility, immunosuppression, kidney transplantation
- Published
- 2017
49. Maintenance of the paraspinal muscles may protect against radiographic knee osteoarthritis
- Author
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Azuma K, Sera Y, Shinjo T, Takayama M, Shiomi E, Momoshima S, Iwao Y, Ishida H, and Matsumoto H
- Subjects
Radiographic knee osteoarthritis (RKOA) ,Paraspinal muscle cross sectional area ,Paraspinal muscle ,attenuation ,Lean body mass (LBM) ,Fat mass (FM) ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Koichiro Azuma,1 Yasushi Sera,1 Takuma Shinjo,1 Michiyo Takayama,2 Eisuke Shiomi,2 Suketaka Momoshima,2 Yasushi Iwao,2 Hiroyuki Ishida,3 Hideo Matsumoto1 1Institute for Integrated Sports Medicine, Keio University School of Medicine, 2Center for Preventive Medicine, Keio University Hospital, Shinjuku-ku, Tokyo, 3Sports Medicine Research Center, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan Background: Knee osteoarthritis (OA) is an increasing health problem worldwide. So far, only obesity and quadriceps weakness are identified as modifiable risk factors for knee OA. Core muscle strengthening is becoming increasingly popular among older adults because of its ability to enhance the activities of daily living during old age. This study investigated the associations of the size and quality of the abdominal trunk muscles with radiographic knee osteoarthritis (RKOA). Methods: From 2012 to 2016, data were collected from 146 males and 135 females (age 63.9±13.4 years, BMI 23.2±3.8 kg/m2) at annual musculoskeletal examinations, including knee radiographs and body composition analyses, by dual-energy X-ray absorptiometry. Cross-sectional areas of abdominal trunk muscles were measured using a single-slice computed tomography scan image obtained at the level of the umbilicus. Results: The prevalence of RKOA was 21.2% in males and 28.1% in females. Compared to subjects without RKOA, subjects with RKOA were ~6 years older and had smaller paraspinal muscle (38.4±8.7 vs 33.1±10.1 cm2, p
- Published
- 2017
50. 食道エンドサイト観察におけるDeep learning AI診断
- Author
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Kumagai, Y., primary, Kawada, K., additional, Takubo, K., additional, Ishikawa, H., additional, Toyomasu, Y., additional, Ishiguro, T., additional, Matsuyama, T., additional, Mochiki, E., additional, and Ishida, H., additional
- Published
- 2023
- Full Text
- View/download PDF
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