5,268 results on '"Ishida, M."'
Search Results
2. Scaling slowly rotating asteroids by stellar occultations
- Author
-
Marciniak, A., Ďurech, J., Choukroun, A., Hanuš, J., Ogłoza, W., Szakáts, R., Molnár, L., Pál, A., Monteiro, F., Frappa, E., Beisker, W., Pavlov, H., Moore, J., Adomavičienė, R., Aikawa, R., Andersson, S., Antonini, P., Argentin, Y., Asai, A., Assoignon, P., Barton, J., Baruffetti, P., Bath, K. L., Behrend, R., Benedyktowicz, L., Bernasconi, L., Biguet, G., Billiani, M., Błażewicz, D., Boninsegna, R., Borkowski, M., Bosch, J., Brazill, S., Bronikowska, M., Bruno, A., Bąk, M. Butkiewicz, Caron, J., Casalnuovo, G., Castellani, J. J., Ceravolo, P., Conjat, M., Delincak, P., Delpau, J., Demeautis, C., Demirkol, A., Dróżdż, M., Duffard, R., Durandet, C., Eisfeldt, D., Evangelista, M., Fauvaud, S., Fauvaud, M., Ferrais, M., Filipek, M., Fini, P., Fukui, K., Gährken, B., Geier, S., George, T., Goffin, B., Golonka, J., Goto, T., Grice, J., Guhl, K., Halíř, K., Hanna, W., Harman, M., Hashimoto, A., Hasubick, W., Higgins, D., Higuchi, M., Hirose, T., Hirsch, R., Hofschulz, O., Horaguchi, T., Horbowicz, J., Ida, M., Ignácz, B., Ishida, M., Isobe, K., Jehin, E., Joachimczyk, B., Jones, A., Juan, J., Kamiński, K., Kamińska, M. K., Kankiewicz, P., Kasebe, H., Kattentidt, B., Kim, D. -H., Kim, M. -J., Kitazaki, K., Klotz, A., Komraus, M., Konstanciak, I., Tóth, R. Könyves, Kouno, K., Kowald, E., Krajewski, J., Krannich, G., Kreutzer, A., Kryszczyńska, A., Kubánek, J., Kudak, V., Kugel, F., Kukita, R., Kulczak, P., Lazzaro, D., Licandro, J., Livet, F., Maley, P., Manago, N., Mánek, J., Manna, A., Matsushita, H., Meister, S., Mesquita, W., Messner, S., Michelet, J., Michimani, J., Mieczkowska, I., Morales, N., Motyliński, M., Murawiecka, M., Newman, J., Nikitin, V., Nishimura, M., Oey, J., Oszkiewicz, D., Owada, M., Pakštienė, E., Pawłowski, M., Pereira, W., Perig, V., Perła, J., Pilcher, F., Podlewska-Gaca, E., Polák, J., Polakis, T., Polińska, M., Popowicz, A., Richard, F., Rives, J. J., Rodrigues, T., Rogiński, Ł., Rondón, E., Rottenborn, M., Schäfer, R., Schnabel, C., Schreurs, O., Selva, A., Simon, M., Skiff, B., Skrutskie, M., Skrzypek, J., Sobkowiak, K., Sonbas, E., Sposetti, S., Stuart, P., Szyszka, K., Terakubo, K., Thomas, W., Trela, P., Uchiyama, S., Urbanik, M., Vaudescal, G., Venable, R., Watanabe, Ha., Watanabe, Hi., Winiarski, M., Wróblewski, R., Yamamura, H., Yamashita, M., Yoshihara, H., Zawilski, M., Zelený, P., Żejmo, M., Żukowski, K., and Żywica, S.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
As evidenced by recent survey results, majority of asteroids are slow rotators (P>12 h), but lack spin and shape models due to selection bias. This bias is skewing our overall understanding of the spins, shapes, and sizes of asteroids, as well as of their other properties. Also, diameter determinations for large (>60km) and medium-sized asteroids (between 30 and 60 km) often vary by over 30% for multiple reasons. Our long-term project is focused on a few tens of slow rotators with periods of up to 60 hours. We aim to obtain their full light curves and reconstruct their spins and shapes. We also precisely scale the models, typically with an accuracy of a few percent. We used wide sets of dense light curves for spin and shape reconstructions via light-curve inversion. Precisely scaling them with thermal data was not possible here because of poor infrared data: large bodies are too bright for WISE mission. Therefore, we recently launched a campaign among stellar occultation observers, to scale these models and to verify the shape solutions, often allowing us to break the mirror pole ambiguity. The presented scheme resulted in shape models for 16 slow rotators, most of them for the first time. Fitting them to stellar occultations resolved previous inconsistencies in size determinations. For around half of the targets, this fitting also allowed us to identify a clearly preferred pole solution, thus removing the ambiguity inherent to light-curve inversion. We also address the influence of the uncertainty of the shape models on the derived diameters. Overall, our project has already provided reliable models for around 50 slow rotators. Such well-determined and scaled asteroid shapes will, e.g. constitute a solid basis for density determinations when coupled with mass information. Spin and shape models continue to fill the gaps caused by various biases., Comment: Accepted to Astronomy & Astrophysics. 12 pages + appendices
- Published
- 2023
- Full Text
- View/download PDF
3. The design and performance of the XL-Calibur anticoincidence shield
- Author
-
Iyer, N. K., Kiss, M., Pearce, M., Stana, T. -A., Awaki, H., Bose, R. G., Dasgupta, A., De Geronimo, G., Gau, E., Hakamata, T., Ishida, M., Ishiwata, K., Kamogawa, W., Kislat, F., Kitaguchi, T., Krawczynski, H., Lisalda, L., Maeda, Y., Matsumoto, H., Miyamoto, A., Miyazawa, T., Mizuno, T., Rauch, B. F., Cavero, N. Rodriguez, Sakamoto, N., Sato, J., Spooner, S., Takahashi, H., Takeo, M., Tamagawa, T., Uchida, Y., West, A. T., Wimalasena, K., and Yoshimoto, M.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The XL-Calibur balloon-borne hard X-ray polarimetry mission comprises a Compton-scattering polarimeter placed at the focal point of an X-ray mirror. The polarimeter is housed within a BGO anticoincidence shield, which is needed to mitigate the considerable background radiation present at the observation altitude of ~40 km. This paper details the design, construction and testing of the anticoincidence shield, as well as the performance measured during the week-long maiden flight from Esrange Space Centre to the Canadian Northwest Territories in July 2022. The in-flight performance of the shield followed design expectations, with a veto threshold <100 keV and a measured background rate of ~0.5 Hz (20-40 keV). This is compatible with the scientific goals of the mission, where %-level minimum detectable polarisation is sought for a Hz-level source rate., Comment: Submitted to Nuclear Instruments and Methods A
- Published
- 2022
- Full Text
- View/download PDF
4. Mite allergen levels and fungal counts in children's bedding in four widely separated towns in Japan
- Author
-
Oshikata, C., Watanabe, M., Hashimoto, K., Yamazaki, A., Kobayashi, N., Konuma, R., Ishida, M., Kobayashi, S., Shimada, T., Kaneko, T., Kamata, Y., Kuriyama, S., Kure, S., Yanai, M., and Tsurikisawa, N.
- Published
- 2024
- Full Text
- View/download PDF
5. XL-Calibur -- a second-generation balloon-borne hard X-ray polarimetry mission
- Author
-
Abarr, Q., Awaki, H., Baring, M. G., Bose, R., De Geronimo, G., Dowkontt, P., Errando, M., Guarino, V., Hattori, K., Hayashida, K., Imazato, F., Ishida, M., Iyer, N. K., Kislat, F., Kiss, M., Kitaguchi, T., Krawczynski, H., Lisalda, L., Matake, H., Maeda, Y., Matsumoto, H., Mineta, T., Miyazawa, T., Mizuno, T., Okajima, T., Pearce, M., Rauch, B. F., Ryde, F., Shreves, C., Spooner, S., Stana, T. -A., Takahashi, H., Takeo, M., Tamagawa, T., Tamura, K., Tsunemi, H., Uchida, N., Uchida, Y., West, A. T., Wulf, E. A., and Yamamoto, R.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
XL-Calibur is a hard X-ray (15-80 keV) polarimetry mission operating from a stabilised balloon-borne platform in the stratosphere. It builds on heritage from the X-Calibur mission, which observed the accreting neutron star GX 301-2 from Antarctica, between December 29th 2018 and January 1st 2019. The XL-Calibur design incorporates an X-ray mirror, which focusses X-rays onto a polarimeter comprising a beryllium rod surrounded by Cadmium Zinc Telluride (CZT) detectors. The polarimeter is housed in an anticoincidence shield to mitigate background from particles present in the stratosphere. The mirror and polarimeter-shield assembly are mounted at opposite ends of a 12 m long lightweight truss, which is pointed with arcsecond precision by WASP - the Wallops Arc Second Pointer. The XL-Calibur mission will achieve a substantially improved sensitivity over X-Calibur by using a larger effective area X-ray mirror, reducing background through thinner CZT detectors, and improved anticoincidence shielding. When observing a 1 Crab source for $t_{\rm day}$ days, the Minimum Detectable Polarisation (at 99% confidence level) is $\sim$2$\%\cdot t_{\rm day}^{-1/2}$. The energy resolution at 40 keV is $\sim$5.9 keV. The aim of this paper is to describe the design and performance of the XL-Calibur mission, as well as the foreseen science programme., Comment: 19 pages, 17 figures. Accepted for publication in Astroparticle Physics
- Published
- 2020
- Full Text
- View/download PDF
6. Fremanezumab for Episodic Migraine Prevention in Japanese Patients: Subgroup Analysis from Two International Trials
- Author
-
Saigoh K, Takeshima T, Nakai M, Shibasaki Y, Ishida M, Ning X, Barash S, Isogai Y, and Koga N
- Subjects
calcitonin gene-related peptide ,episodic migraine ,fremanezumab ,japanese ,Medicine (General) ,R5-920 - Abstract
Kazumasa Saigoh,1 Takao Takeshima,2 Masami Nakai,3 Yoshiyuki Shibasaki,4 Miki Ishida,5 Xiaoping Ning,6 Steve Barash,6 Yuki Isogai,4 Nobuyuki Koga7 1Department of Neurology, Kindai University School of Medicine, Osaka, Japan; 2Headache Center, Department of Neurology, Tominaga Hospital, Osaka, Japan; 3Medical Affairs, Otsuka Pharmaceutical Co, Ltd, Osaka, Japan; 4Medical Affairs, Otsuka Pharmaceutical Co, Ltd, Tokyo, Japan; 5Headquarters of Clinical Development, Otsuka Pharmaceutical Co, Ltd, Osaka, Japan; 6Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA; 7Medical Affairs, Otsuka Pharmaceutical Co, Ltd, Tokushima, JapanCorrespondence: Masami Nakai, Medical Affairs, Otsuka Pharmaceutical Co., Ltd, 3-2-27 Otedori, Chuo-ku, Osaka, 540-0021, Japan, Tel +81-80-9026-3806, Email nakai.masami@otsuka.jpPurpose: The monoclonal antibody fremanezumab has been shown effective and well tolerated in numerous Phase 2 and Phase 3 trials. This subgroup analysis of the international HALO episodic migraine (EM; [NCT02629861]) trial and a similarly designed phase 2b/3 trial in Japanese and Korean patients (NCT03303092) sought to evaluate the efficacy and safety of fremanezumab in Japanese patients with EM.Patients and Methods: In both trials, eligible patients were randomly assigned at baseline to receive subcutaneous monthly fremanezumab, quarterly fremanezumab, or placebo in a 1:1:1 ratio. The primary endpoint was the mean change from baseline in the monthly (28-day) average number of migraine days during the 12-week period after the first dose of fremanezumab or placebo. Secondary endpoints assessed other aspects of efficacy, including disability and medication use.Results: A total of 301 patients in the Japanese and Korean phase 2b/3 trial and 75 patients in the HALO EM trial were Japanese with baseline and treatment characteristics similar between treatment groups. According to ANCOVA analysis of the primary endpoint, both fremanezumab quarterly and monthly led to greater reductions in the monthly (28-day) average number of migraine days than placebo. This was supported by MMRM analysis of the primary endpoint over the initial 4 weeks, highlighting the rapid onset of action of fremanezumab. Results of secondary endpoint analysis supported the primary endpoint analyses. Fremanezumab was well tolerated with no new safety signals seen in this population of Japanese patients.Conclusion: Fremanezumab appears to be an effective and well-tolerated preventive medication for Japanese patients with EM.Keywords: calcitonin gene-related peptide, episodic migraine, fremanezumab, Japanese
- Published
- 2023
7. Fremanezumab for Chronic Migraine Prevention in Japanese Patients: Subgroup Analysis from Two International Trials
- Author
-
Saigoh K, Takeshima T, Nakai M, Shibasaki Y, Ishida M, Ning X, Barash S, Isogai Y, and Koga N
- Subjects
calcitonin gene-related peptide ,chronic migraine ,fremanezumab ,japanese ,Medicine (General) ,R5-920 - Abstract
Kazumasa Saigoh,1 Takao Takeshima,2 Masami Nakai,3 Yoshiyuki Shibasaki,4 Miki Ishida,5 Xiaoping Ning,6 Steve Barash,6 Yuki Isogai,4 Nobuyuki Koga7 1Department of Neurology, Kindai University School of Medicine, Osaka, Japan; 2Headache Center, Department of Neurology, Tominaga Hospital, Osaka, Japan; 3Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan; 4Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan; 5Headquarters of Clinical Development, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan; 6Teva Branded Pharmaceutical Products R&D, Inc., West Chester, PA, USA; 7Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokushima, JapanCorrespondence: Masami Nakai, Medical Affairs, Otsuka Pharmaceutical Co., Ltd., 3-2-27 Otedori, Chuo-ku, Osaka, 540-0021, Japan, Tel +81-80-9026-3806, Email nakai.masami@otsuka.jpPurpose: Fremanezumab monoclonal antibody therapy has demonstrated efficacy for chronic migraine (CM) with rapid onset and good tolerability. This subgroup analysis of two clinical trials (Japanese and Korean CM Phase 2b/3 [NCT03303079] and HALO CM Phase 3 [NCT02621931]) aimed to evaluate the efficacy and safety of fremanezumab in Japanese patients.Patients and Methods: Both trials randomly assigned eligible patients at baseline (1:1:1 ratio) to subcutaneous monthly fremanezumab, quarterly fremanezumab, or placebo at 4-week intervals. The primary endpoint was the mean change from baseline in the monthly (28-day) average number of headache days of at least moderate severity during the 12-week period after the first dose of study medication (analyzed by ANCOVA over 12 weeks and MMRM over initial 4 weeks). Secondary endpoints examined other aspects of efficacy, including medication use and disability.Results: A total of 479 and 109 patients were Japanese in the Japanese and Korean CM Phase 2b/3 and HALO CM trials, respectively. Baseline and treatment characteristics were generally similar between treatment groups for both trials. Results of subgroup analyses for the primary endpoint according to ANCOVA demonstrated the superiority of fremanezumab over placebo in Japanese patients (quarterly fremanezumab, p=0.0005; monthly fremanezumab, p=0.0002 in both trials). Results using the MMRM analysis confirmed the rapid onset of action in this population. Results of the secondary endpoints further supported the efficacy of fremanezumab in Japanese patients. Fremanezumab was well tolerated with nasopharyngitis and injection-site reactions representing the most common adverse events in all treatment groups.Conclusion: Despite the limitations of subgroup analyses, these consistent results confirm the efficacy and tolerability of fremanezumab in Japanese patients with CM.Keywords: calcitonin gene-related peptide, chronic migraine, fremanezumab, Japanese
- Published
- 2023
8. Super DIOS Project for Exploring “Dark Baryon”
- Author
-
Sato, K., Yamasaki, N. Y., Ishida, M., Maeda, Y., Mitsuda, K., Ishisaki, Y., Fujita, Y., Ezoe, Y., Mitsuishi, I., Tawara, Y., Osato, K., Kawai, N., Matsushita, K., Nagai, D., Yoshikawa, K., Fujimoto, R., Tsuru, T. G., Ota, N., Yamada, S., Ichinohe, Y., Uchida, Y., and Nakashima, Y.
- Published
- 2022
- Full Text
- View/download PDF
9. The design and performance of the XL-Calibur anticoincidence shield
- Author
-
Iyer, N.K., Kiss, M., Pearce, M., Stana, T.-A., Awaki, H., Bose, R.G., Dasgupta, A., De Geronimo, G., Gau, E., Hakamata, T., Ishida, M., Ishiwata, K., Kamogawa, W., Kislat, F., Kitaguchi, T., Krawczynski, H., Lisalda, L., Maeda, Y., Matsumoto, H., Miyamoto, A., Miyazawa, T., Mizuno, T., Rauch, B.F., Cavero, N. Rodriguez, Sakamoto, N., Sato, J., Spooner, S., Takahashi, H., Takeo, M., Tamagawa, T., Uchida, Y., West, A.T., Wimalasena, K., and Yoshimoto, M.
- Published
- 2023
- Full Text
- View/download PDF
10. Inorbit Performance of the Hard X-ray Telescope (HXT) on board the Hitomi (ASTRO-H) satellite
- Author
-
Matsumoto, H., Awaki, H., Ishida, M., Furuzawa, A., Yamauchi, S., Maeda, Y., Mitsuishi, I., Haba, Y., Hayashi, T., Iizuka, R., Ishibashi, K., Itoh, M., Kunieda, H., Miyazawa, T., Mori, H., Okajima, T., Sugita, S., Tamura., K., and Tawara, Y.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Hitomi (ASTRO-H) carries two Hard X-ray Telescopes (HXTs) that can focus X-rays up to 80 keV. Combined with the Hard X-ray Imagers (HXIs) that detect the focused X-rays, imaging spectroscopy in the high-energy band from 5 keV to 80 keV is made possible. We studied characteristics of HXTs after the launch such as the encircled energy function (EEF) and the effective area using the data of a Crab observation. The half power diameters (HPDs) in the 5--80 keV band evaluated from the EEFs are 1.59 arcmin for HXT-1 and 1.65 arcmin for HXT-2. Those are consistent with the HPDs measured with ground experiments when uncertainties are taken into account. We can conclude that there is no significant change in the characteristics of the HXTs before and after the launch. The off-axis angle of the aim point from the optical axis is evaluated to be less than 0.5 arcmin for both HXT-1 and HXT-2. The best-fit parameters for the Crab spectrum obtained with the HXT-HXI system are consistent with the canonical values., Comment: 13 pages, 5 figures; the acknowledgment was modified
- Published
- 2018
- Full Text
- View/download PDF
11. Effects of mite allergen avoidance in children in two distant towns in Japan
- Author
-
Oshikata, C., Watanabe, M., Hashimoto, K., Yamazaki, A., Kobayashi, N., Konuma, R., Ishida, M., Kobayashi, S., Shimada, T., Kaneko, T., Kamata, Y., Kuriyama, S., Kure, S., Yanai, M., and Tsurikisawa, N.
- Published
- 2022
- Full Text
- View/download PDF
12. Mineralogy, geochemistry and microbiology insights into precipitation of stibnite and orpiment at the Daiyon-Yonaguni Knoll (Okinawa Trough) hydrothermal barite deposits
- Author
-
Dekov, V.M., Kyono, K., Yasukawa, K., Guéguen, B., Ivarsson, M., Kamenov, G.D., Yamanaka, T., Asael, D., Ishida, M., Cavalcante, L.L., Kato, Y., Toki, T., and Ishibashi, J.-I.
- Published
- 2022
- Full Text
- View/download PDF
13. In-orbit performance of the soft X-ray imaging system aboard Hitomi (ASTRO-H)
- Author
-
Nakajima, H., Maeda, Y., Uchida, H., Tanaka, T., Tsunemi, H., Hayashida, K., Tsuru, T. G., Dotani, T., Nagino, R., Inoue, S., Ozaki, M., Tomida, H., Natsukari, C., Ueda, S., Mori, K., Yamauchi, M., Hatsukade, I., Nishioka, Y., Sakata, M., Beppu, T., Honda, D., Nobukawa, M., Hiraga, J. S., Kohmura, T., Murakami, H., Nobukawa, K. K., Bamba, A., Doty, J. P., Iizuka, R., Sato, T., Kurashima, S., Nakaniwa, N., Asai, R., Ishida, M., Mori, H., Soong, Y., Okajima, T., Serlemitsos, P., Tawara, Y., Mitsuishi, I., Ishibashi, K., Tamura, K., Hayashi, T., Furuzawa, A., Sugita, S., Miyazawa, T., Awaki, H., Miller, E. D., and Yamaguchi, H.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We describe the in-orbit performance of the soft X-ray imaging system consisting of the Soft X-ray Telescope and the Soft X-ray Imager aboard Hitomi. Verification and calibration of imaging and spectroscopic performance are carried out making the best use of the limited data of less than three weeks. Basic performance including a large field of view of 38'x38' is verified with the first light image of the Perseus cluster of galaxies. Amongst the small number of observed targets, the on-minus-off pulse image for the out-of-time events of the Crab pulsar enables us to measure a half power diameter of the telescope as about 1.3'. The average energy resolution measured with the onboard calibration source events at 5.89 keV is 179 pm 3 eV in full width at half maximum. Light leak and cross talk issues affected the effective exposure time and the effective area, respectively, because all the observations were performed before optimizing an observation schedule and parameters for the dark level calculation. Screening the data affected by these two issues, we measure the background level to be 5.6x10^{-6} counts s^{-1} arcmin^{-2} cm^{-2} in the energy band of 5-12 keV, which is seven times lower than that of the Suzaku XIS-BI., Comment: Accepted for publication in PASJ. 17 pages, 18 figures
- Published
- 2017
- Full Text
- View/download PDF
14. Development of an IoT-Based Monitoring System for Healthcare: A Preliminary Study
- Author
-
Ishida, M., Ushioda, S., Nagasawa, Y., Komuroa, Y., Tang, Z., Hu, L., Tamura, T., Sakatani, K., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Ryu, Pan-Dong, editor, LaManna, Joseph C., editor, Harrison, David K., editor, and Lee, Sang-Suk, editor
- Published
- 2020
- Full Text
- View/download PDF
15. Relationship Between Cerebral Blood Oxygenation and Electrical Activity During Mental Stress Tasks: Simultaneous Measurements of NIRS and EEG
- Author
-
Nagasawa, Y., Ishida, M., Komuro, Y., Ushioda, S., Hu, L., Sakatani, K., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Ryu, Pan-Dong, editor, LaManna, Joseph C., editor, Harrison, David K., editor, and Lee, Sang-Suk, editor
- Published
- 2020
- Full Text
- View/download PDF
16. Discovery of Rapidly Moving Partial X-ray Absorbers within gamma Cassiopeiae
- Author
-
Hamaguchi, K., Oskinova, L., Russell, C. M. P., Petre, R., Enoto, T., Morihana, K., and Ishida, M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Gamma Cassiopeiae is an enigmatic Be star with unusually strong hard X-ray emission. The Suzaku observatory detected six rapid X-ray spectral hardening events called "softness dips" in a ~100 ksec duration observation in 2011. All the softness dip events show symmetric softness ratio variations, and some of them have flat bottoms apparently due to saturation. The softness dip spectra are best described by either ~40% or ~70% partial covering absorption to kT ~12 keV plasma emission by matter with a neutral hydrogen column density of ~2-8e21 cm-2, while the spectrum outside of these dips is almost free of absorption. This result suggests the presence of two distinct X-ray emitting spots in the gamma Cas system, perhaps on a white dwarf companion with dipole mass accretion. The partial covering absorbers may be blobs in the Be stellar wind, the Be disk, or rotating around the white dwarf companion. Weak correlations of the softness ratios to the hard X-ray flux suggest the presence of stable plasmas at kT ~0.9 and 5 keV, which may originate from the Be or white dwarf winds. The formation of a Be star and white dwarf binary system requires mass transfer between two stars; gamma Cas may have experienced such activity in the past., Comment: 16 pages, 5 figures, accepted for publication in Astrophysical Journal
- Published
- 2016
- Full Text
- View/download PDF
17. Flexible heat-flow sensing sheets based on the longitudinal spin Seebeck effect using one-dimensional spin-current conducting films
- Author
-
Kirihara, A., Kondo, K., Ishida, M., Ihara, K., Iwasaki, Y., Someya, H., Matsuba, A., Uchida, K., Saitoh, E., Yamamoto, N., Kohmoto, S., and Murakami, T.
- Subjects
Condensed Matter - Materials Science - Abstract
We demonstrated a flexible thermoelectric (TE) sheet based on the longitudinal spin Seebeck effect (LSSE) that is especially suitable for heat-flow sensing applications. This TE sheet contained a Ni0.2Zn0.3Fe2.5O4 film which was formed on a flexible plastic sheet using a spray-coating method known as ferrite plating. The experimental results suggest that the ferrite-plated film, which has a columnar crystal structure aligned perpendicular to the film plane, functions as a unique one-dimensional spin-current conductor suitable for bendable LSSE-based sensors.
- Published
- 2016
- Full Text
- View/download PDF
18. XL-Calibur – a second-generation balloon-borne hard X-ray polarimetry mission
- Author
-
Abarr, Q., Awaki, H., Baring, M.G., Bose, R., De Geronimo, G., Dowkontt, P., Errando, M., Guarino, V., Hattori, K., Hayashida, K., Imazato, F., Ishida, M., Iyer, N.K., Kislat, F., Kiss, M., Kitaguchi, T., Krawczynski, H., Lisalda, L., Matake, H., Maeda, Y., Matsumoto, H., Mineta, T., Miyazawa, T., Mizuno, T., Okajima, T., Pearce, M., Rauch, B.F., Ryde, F., Shreves, C., Spooner, S., Stana, T.-A., Takahashi, H., Takeo, M., Tamagawa, T., Tamura, K., Tsunemi, H., Uchida, N., Uchida, Y., West, A.T., Wulf, E.A., and Yamamoto, R.
- Published
- 2021
- Full Text
- View/download PDF
19. ASTRO-H White Paper - White Dwarf
- Author
-
Mukai, K., Yuasa, T., Harayama, A., Hayashi, T., Ishida, M., Long, K. S., Terada, Y., and Tsujimoto, M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
Interacting binaries in which a white dwarf accretes material from a companion --- cataclysmic variables (CVs) in which the mass loss is via Roche-lobe overflow, and symbiotic stars in which the white dwarf captures the wind of a late type giant --- are relatively commonplace. They display a wide range of behaviors in the optical, X-rays, and other wavelengths, which still often baffles observers and theorists alike. They are likely to be a significant contributor to the Galactic ridge X-ray emission, and the possibility that some CVs or symbiotic stars may be the progenitors of some of the Type Ia supernovae deserves serious consideration. Furthermore, these binaries serve as excellent laboratories in which to study physics of X-ray emission from high density plasma, accretion physics, reflection, and particle acceleration. ASTRO-H is well-matched to the study of X-ray emission from many of these objects. In particular, the excellent spectral resolution of the SXS will enable dynamical studies of the X-ray emitting plasma. We also discuss the possibility of identifying an accreting, near-Chandrasekhar-mass white dwarf by measuring the gravitational redshift of the 6.4 keV line., Comment: 25 pages, 20 figures, ASTRO-H White Paper
- Published
- 2014
20. ASTRO-H White Paper - Older Supernova Remnants and Pulsar Wind Nebulae
- Author
-
Long, K. S., Bamba, A., Aharonian, F., Foster, A., Funk, S., Hiraga, J., Hughes, J., Ishida, M., Katsuda, S., Matsumoto, H., Mori, K., Nakajima, H., Nakamori, T., Ozaki, M., Safi-Harb, S., Sawada, M., Tamagawa, T., Tamura, K., Tanaka, T., Tsunemi, H., Uchida, H., Uchiyama, Y., and Yamauchi, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
Most supernova remnants (SNRs) are old, in the sense that their structure has been profoundly modified by their interaction with the surrounding interstellar medium (ISM). Old SNRs are very heterogenous in terms of their appearance, reflecting differences in their evolutionary state, the environments in which SNe explode and in the explosion products. Some old SNRs are seen primarily as a result of a strong shock wave interacting with the ISM. Others, the so-called mixed-morphology SNRs, show central concentrations of emission, which may still show evidence of emission from the ejecta. Yet others, the pulsar wind nebulae (PWNe), are seen primarily as a result of emission powered by a pulsar; these SNRs often lack the detectable thermal emission from the primary shock. The underlying goal in all studies of old SNRs is to understand these differences, in terms of the SNe that created them, the nature of the ISM into which they are expanding, and the fundamental physical processes that govern their evolution. Here we identify three areas of study where ASTRO-H can make important contributions. These are constraining abundances and physical processes in mature limb-brightened SNRs, understanding the puzzling nature of mixed-morphology SNRs, and exploring the nature of PWNe. The Soft X-ray Spectrometer (SXS) on-board ASTRO-H will, as a result of its high spectral resolution, be the primary tool for addressing problems associated with old SNRs, supported by hard X-ray observations with the Hard X-ray Imager (HXI) to obtain broad band X-ray coverage., Comment: 25 pages, 17 figures, ASTRO-H White Paper
- Published
- 2014
21. ASTRO-H White Paper - Young Supernova Remnants
- Author
-
Hughes, J. P., Safi-Harb, S., Bamba, A., Katsuda, S., Leutenegger, M., Long, K. S., Maeda, Y., Mori, K., Nakajima, H., Sawada, M., Tanaka, T., Uchida, H., Yamaguchi, H., Aharonian, F., Funk, S., Hiraga, J., Ishida, M., Koyama, K., Matsumoto, H., Nobukawa, M., Ozaki, M., Tamagawa, T., Tsunemi, H., Tomida, H., Uchiyama, Y., and Uno, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
Thanks to the unprecedented spectral resolution and sensitivity of the Soft X-ray Spectrometer (SXS) to soft thermal X-ray emission, ASTRO-H will open a new discovery window for understanding young, ejecta-dominated, supernova remnants (SNRs). In particular we study how ASTRO-H observations will address, comprehensively, three key topics in SNR research: (1) using abundance measurements to unveil SNR progenitors, (2) using spatial and velocity distribution of the ejecta to understand supernova explosion mechanisms, (3) revealing the link between the thermal plasma state of SNRs and the efficiency of their particle acceleration., Comment: 38 pages, 19 figures, ASTRO-H White Paper
- Published
- 2014
22. Collisional history of Ryugu’s parent body from bright surface boulders
- Author
-
Tatsumi, E., Sugimoto, C., Riu, L., Sugita, S., Nakamura, T., Hiroi, T., Morota, T., Popescu, M., Michikami, T., Kitazato, K., Matsuoka, M., Kameda, S., Honda, R., Yamada, M., Sakatani, N., Kouyama, T., Yokota, Y., Honda, C., Suzuki, H., Cho, Y., Ogawa, K., Hayakawa, M., Sawada, H., Yoshioka, K., Pilorget, C., Ishida, M., Domingue, D., Hirata, N., Sasaki, S., de León, J., Barucci, M. A., Michel, P., Suemitsu, M., Saiki, T., Tanaka, S., Terui, F., Nakazawa, S., Kikuchi, S., Yamaguchi, T., Ogawa, N., Ono, G., Mimasu, Y., Yoshikawa, K., Takahashi, T., Takei, Y., Fujii, A., Yamamoto, Y., Okada, T., Hirose, C., Hosoda, S., Mori, O., Shimada, T., Soldini, S., Tsukizaki, R., Mizuno, T., Iwata, T., Yano, H., Ozaki, M., Abe, M., Ohtake, M., Namiki, N., Tachibana, S., Arakawa, M., Ikeda, H., Ishiguro, M., Wada, K., Yabuta, H., Takeuchi, H., Shimaki, Y., Shirai, K., Hirata, N., Iijima, Y., Tsuda, Y., Watanabe, S., and Yoshikawa, M.
- Published
- 2021
- Full Text
- View/download PDF
23. Clinical Characteristics and Outcomes of Patients with Asthma–COPD Overlap in Japanese Patients with COPD
- Author
-
Kobayashi S, Hanagama M, Ishida M, Ono M, Sato H, Yamanda S, and Yanai M
- Subjects
asthma ,asthma–copd overlap ,copd ,exacerbations ,mortality ,Diseases of the respiratory system ,RC705-779 - Abstract
Seiichi Kobayashi,1 Masakazu Hanagama,1 Masatsugu Ishida,1 Manabu Ono,1 Hikari Sato,1 Shinsuke Yamanda,1,2 Masaru Yanai1 1Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan; 2Department of Pulmonary Medicine, Sendai Kosei Hospital, Sendai, Miyagi, JapanCorrespondence: Seiichi KobayashiDepartment of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichishita, Hebita, Ishinomaki 986-8522, JapanTel +81 225 21 7220Fax +81 225 96 0122Email skoba-thk@umin.ac.jpPurpose: Asthma–COPD overlap (ACO) has been reported as an association with a lower quality of life, frequent exacerbations, and higher mortality than those with COPD alone. However, clinical characteristics and outcomes of ACO remain controversial.Patients and Methods: We conducted a prospective observational study analyzing data of patients with stable COPD enrolled from the Ishinomaki COPD Network Registry. Patients with features of asthma who had a history of respiratory symptoms that vary over time and intensity, together with documented variable expiratory airflow limitation, were identified, and then defined as having ACO. The characteristics, frequency of exacerbations, and mortality during the 3-year follow-up were compared between patients with ACO and patients with COPD alone.Results: Among 387 patients with COPD, 41 (10.6%) were identified as having ACO. Patients with ACO tended to be younger, have higher BMI, have a shorter smoking history, and use more respiratory medications, especially inhaled corticosteroids. Inflammatory biomarkers including fractional exhaled nitric oxide, blood eosinophil count, total immunoglobulin E (IgE) level, and presence of antigen-specific IgE were significantly higher in patients with ACO than in those with COPD alone. Lung function, mMRC score, CAT score, and comorbidity index were not different between the groups. The annual rate of all exacerbations and severe exacerbations required hospital admission were not different between ACO and COPD alone (0.20 vs 0.14, 0.12 vs 0.10, events per person, respectively). Mortality was significantly higher in patients with COPD alone compared with those with ACO during the study period (P=0.037).Conclusion: The results of our study indicate that ACO is not associated with poor clinical features nor outcomes in an outpatient COPD cohort receiving appropriate treatment.Keywords: asthma, asthma–COPD overlap, COPD, exacerbations, mortality
- Published
- 2020
24. Efficacy And Safety Of Controlled-Release Oxycodone For The Management Of Moderate-To-Severe Chronic Non-Cancer Pain In Japanese Patients: Results From An Open-Label Study
- Author
-
Kawamata M, Iseki M, Kawakami M, Yabuki S, Sasaki T, Ishida M, Nishiyori A, Hida H, and Kikuchi S
- Subjects
analgesics ,chronic pain ,japan ,opioids ,Medicine (General) ,R5-920 - Abstract
Mikito Kawamata,1 Masako Iseki,2 Mamoru Kawakami,3 Shoji Yabuki,4 Takuma Sasaki,5 Mitsuhiro Ishida,5 Atsushi Nishiyori,5 Hideaki Hida,6 Shin-ichi Kikuchi4 1Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Japan; 2Department of Anesthesiology and Pain Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan; 3Spine Care Center, Wakayama Medical University Kihoku Hospital, Wakayama, Japan; 4Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan; 5Clinical Development Department, Shionogi & Co., Ltd., Osaka, Japan; 6Biostatistics Center, Shionogi & Co., Ltd., Osaka, JapanCorrespondence: Takuma SasakiClinical Development Department, Shionogi & Co., Ltd., 12F, Hankyu Terminal Bld., 1-4, Shibata 1-chome, Kita-ku, Osaka 530-0012, JapanTel +81-6-6485-5090Fax +81-6-6375-5780Email Takuma.sasaki@shionogi.co.jpPurpose: To assess the efficacy and safety of S-8117, an oral, controlled-release formulation of oxycodone hydrochloride, in Japanese patients with chronic non-cancer pain (CNCP).Patients and methods: In this multicenter, non-randomized, open-label, 2-part (part 1, dose-titration followed by maintenance period; part 2, long-term administration period) study at 38 centers in Japan (2013–2015), adult patients with CNCP for ≥12 weeks were administered S-8117. The primary endpoint was proportion of patients with successful maintenance of pain control in part 1 and long-term safety in part 2. Secondary endpoints included time to inadequate analgesia, rate of transition to the maintenance period, and discontinuation due to inadequate analgesia/adverse events (AEs), Brief Pain Inventory (BPI) pain severity, BPI pain interference, 36-item Short Form Health Survey (SF-36) score, and Western Ontario and McMaster Universities (WOMAC) index, Subjective Opioid Withdrawal Scale (SOWS), Clinical Opioid Withdrawal Scale (COWS), Dependency-2-A (D-2-A), and Dependency-2-B (D-2-B) questionnaires.Results: Of 130 patients (mean age, 63.6 years; women, 62.3%) in the dose-titration period, 95 entered the maintenance period; 60 of 83 who entered the long-term administration period completed it. The proportion of patients (95% confidence interval) with successful maintenance of pain control, transition to maintenance period, and discontinuation due to inadequate analgesia/AEs was 78.9% (69.4–86.6), 73.1% (64.6–80.5), and 21.1% (13.4–30.6), respectively. Time to inadequate analgesia could not be estimated. Changes from baseline in BPI, SF-36, and WOMAC index scores suggested improvements in pain relief and quality of life. Based on the SOWS, COWS, D-2-A and D-2-B questionnaires, no patient developed clinically relevant withdrawal syndrome or was ascertained to have developed drug dependence. Overall, the incidence of treatment-emergent AEs (TEAEs) was 93.8%; most common TEAEs were constipation (49.2%), nausea (42.3%), nasopharyngitis (34.6%), and somnolence (32.3%).Conclusion: These results demonstrate the efficacy and safety of S-8117 in Japanese patients with CNCP.Keywords: analgesics, chronic pain, Japan, opioids
- Published
- 2019
25. Development of UHPFRC overlay method for RC slabs focusing on interface treatment
- Author
-
Watanabe, T., primary, Kanou, T., additional, and Ishida, M., additional
- Published
- 2021
- Full Text
- View/download PDF
26. Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission
- Author
-
Feigin, V, Owolabi, M, Abd-Allah, F, Akinyemi, R, Bhattacharjee, N, Brainin, M, Cao, J, Caso, V, Dalton, B, Davis, A, Dempsey, R, Duprey, J, Feng, W, Ford, G, Gall, S, Gandhi, D, Good, D, Hachinski, V, Hacke, W, Hankey, G, Ishida, M, Johnson, W, Kim, J, Lavados, P, Lindsay, P, Mahal, A, Martins, S, Murray, C, Nguyen, T, Norrving, B, Olaiya, M, Olalusi, O, Pandian, J, Phan, H, Platz, T, Ranta, A, Rehman, S, Roth, G, Sebastian, I, Smith, A, Suwanwela, N, Sylaja, P, Thapa, R, Thrift, A, Uvere, E, Vollset, S, Yavagal, D, Yaria, J, Abera, S, Ibrahim, N, Liu, L, Ovbiagele, B, Piradov, M, Abanto, C, Addissie, A, Adeleye, A, Adilbekov, Y, Adilbekova, B, Adoukonou, T, Aguiar de Sousa, D, Akhmetzhanova, Z, Akpalu, A, El Alaoui-Faris, M, Ameriso, S, Andonova, S, Arsovska, A, Awoniyi, F, Bakhiet, M, Barboza, M, Basri, H, Bath, P, Bereczki, D, Beretta, S, Berkowitz, A, Bernhardt, J, Berzina, G, Bhavsar, B, Bisharyan, M, Bohara, M, Bovet, P, Budincevic, H, Cadilhac, D, Cerimagic, D, Charway-Felli, A, Chen, C, Chin, J, Christensen, H, Chwojnicki, K, Conforto, A, Correia, M, Mora Cuervo, D, Czlonkowska, A, D'Amelio, M, Danielyan, K, Davis, S, Demarin, V, Demchuk, A, Dichgans, M, Dokova, K, Donnan, G, Duran, J, Ekeng, G, Elkind, M, Endres, M, Fischer, U, Flomin, Y, Gankpe, F, Gavidia, M, Gaye Saavedra, A, Gebreyohanns, M, George, M, Gierlotka, M, Giroud, M, Gnedovskaya, E, Goncalves, I, Gongora-Rivera, F, Gunaratne, P, Hamadeh, R, Hamzat, T, Heldner, M, Ibrahim, E, Ihle-Hansen, H, Jee, S, Jiann-Shing, J, Johnston, S, Jovanovic, D, Jurjans, K, Kalani, R, Kalkonde, Y, Kamenova, S, Karaszewski, B, Kelly, P, Kiechl, S, Kondybayeva, A, Korv, J, Kozera, G, Kravchenko, M, Krespi, Y, Krishnamurthi, R, Kruja, J, Kutluk, K, Langhorne, P, Law, Z, Lebedynets, D, Lee, T, Leung, T, Liebeskind, D, Lopez-Jaramillo, P, Lotufo, P, Machline-Carrion, M, Maia, L, Malojcic, B, Markus, H, Marquez-Romero, J, Medina, M, Medukhanova, S, Mehndiratta, M, Miglane, E, Mihejeva, I, Mikulik, R, Mirrakhimov, E, Mohl, S, Munakomi, S, Murphy, S, Musa, K, Nasreldein, A, Nogueira, R, Nolte, C, Noubiap, J, Novarro-Escudero, N, Ocampo, C, O'Donnell, M, Ogun, Y, Ogunniyi, A, Oraby, M, Orken, D, Ozdemir, A, Ozturk, S, Paccot, M, Pereira, T, Peeters, A, Potpara, T, Proios, H, Rathore, F, Sacco, R, Sahathevan, R, Sandset, E, Renato Santos, I, Saposnik, G, Sarfo, F, Sargento-Freitas, J, Sharma, M, Shaw, L, Sheth, K, Shin, Y, Shobhana, A, Silva, S, Tedim Cruz, V, Thakur, K, Thapa, L, Toni, D, Topcuoglu, M, Torales, J, Towfighi, A, Truelsen, T, Tsiskaridze, A, Tulloch-Reid, M, Useche, J, Vanacker, P, Vassilopoulou, S, Vukorepa, G, Vuletic, V, Wahab, K, Wang, W, Wijeratne, T, Wojtyniak, B, Wolfe, C, Yacouba, M, Yang, J, Yifru, Y, Yock-Corrales, A, Yonemoto, N, Yperzeele, L, Zagozdzon, P, Feigin V. L., Owolabi M. O., Abd-Allah F., Akinyemi R. O., Bhattacharjee N. V., Brainin M., Cao J., Caso V., Dalton B., Davis A., Dempsey R., Duprey J., Feng W., Ford G. A., Gall S., Gandhi D., Good D. C., Hachinski V., Hacke W., Hankey G. J., Ishida M., Johnson W., Kim J., Lavados P., Lindsay P., Mahal A., Martins S., Murray C., Nguyen T. P., Norrving B., Olaiya M. T., Olalusi O. V., Pandian J., Phan H., Platz T., Ranta A., Rehman S., Roth G., Sebastian I. A., Smith A. E., Suwanwela N. C., Sylaja P. N., Thapa R., Thrift A. G., Uvere E., Vollset S. E., Yavagal D., Yaria J., Abera S. F., Akinyemi R., Dempsey R. J., Ibrahim N. M., Liu L., Ovbiagele B., Piradov M., Suwanwela N., Abanto C., Addissie A., Adeleye A. O., Adilbekov Y., Adilbekova B., Adoukonou T. A., Aguiar de Sousa D., Akhmetzhanova Z., Akpalu A., El Alaoui-Faris M., Ameriso S. F., Andonova S., Arsovska A., Awoniyi F. E., Bakhiet M., Barboza M. A., Basri H., Bath P. M., Bereczki D., Beretta S., Berkowitz A. L., Bernhardt J., Berzina G., Bhavsar B., Bisharyan M. S., Bohara M., Bovet P., Budincevic H., Cadilhac D. A., Cerimagic D., Charway-Felli A., Chen C., Chin J. H., Christensen H., Chwojnicki K., Conforto A. B., Correia M., Mora Cuervo D. L., Czlonkowska A., D'Amelio M., Danielyan K. E., Davis S., Demarin V., Demchuk A. M., Dichgans M., Dokova K., Donnan G., Duran J. C., Ekeng G., Elkind M. S., Endres M., Fischer U., Flomin Y., Gankpe F., Gavidia M., Gaye Saavedra A., Gebreyohanns M., George M., Gierlotka M., Giroud M., Gnedovskaya E. V., Goncalves I. P., Gongora-Rivera F., Gunaratne P. S., Hamadeh R. R., Hamzat T. -H. K., Heldner M. R., Ibrahim E., Ihle-Hansen H., Jee S., Jiann-Shing J., Johnston S. C., Jovanovic D., Jurjans K., Kalani R., Kalkonde Y., Kamenova S., Karaszewski B., Kelly P., Kiechl S., Kondybayeva A., Korv J., Kozera G., Kravchenko M., Krespi Y., Krishnamurthi R., Kruja J., Kutluk K., Langhorne P., Law Z. K., Lebedynets D., Lee T. -H., Leung T. W., Liebeskind D. S., Lopez-Jaramillo P., Lotufo P. A., Machline-Carrion M. J., Maia L. F., Malojcic B., Markus H. S., Marquez-Romero J. M., Medina M. T., Medukhanova S., Mehndiratta M. M., Miglane E., Mihejeva I., Mikulik R., Mirrakhimov E., Mohl S., Munakomi S., Murphy S., Musa K. I., Nasreldein A., Nogueira R. G., Nolte C. H., Noubiap J. J., Novarro-Escudero N., Ocampo C., O'Donnell M., Ogun Y., Ogunniyi A., Oraby M. I., Orken D. N., Ozdemir A. O., Ozturk S., Paccot M., Pereira T., Peeters A., Potpara T., Proios H., Rathore F. A., Sacco R. L., Sahathevan R., Sandset E. S., Renato Santos I., Saposnik G., Sarfo F. S., Sargento-Freitas J., Sharma M., Shaw L., Sheth K. N., Shin Y. -I., Shobhana A., Silva S. N., Tedim Cruz V., Thakur K., Thapa L. J., Toni D., Topcuoglu M. A., Torales J., Towfighi A., Truelsen T., Tsiskaridze A., Tulloch-Reid M., Useche J. N., Vanacker P., Vassilopoulou S., Vukorepa G., Vuletic V., Wahab K. W., Wang W., Wijeratne T., Wojtyniak B., Wolfe C., Yacouba M. N., Yang J., Yifru Y. M., Yock-Corrales A., Yonemoto N., Yperzeele L., Zagozdzon P., Feigin, V, Owolabi, M, Abd-Allah, F, Akinyemi, R, Bhattacharjee, N, Brainin, M, Cao, J, Caso, V, Dalton, B, Davis, A, Dempsey, R, Duprey, J, Feng, W, Ford, G, Gall, S, Gandhi, D, Good, D, Hachinski, V, Hacke, W, Hankey, G, Ishida, M, Johnson, W, Kim, J, Lavados, P, Lindsay, P, Mahal, A, Martins, S, Murray, C, Nguyen, T, Norrving, B, Olaiya, M, Olalusi, O, Pandian, J, Phan, H, Platz, T, Ranta, A, Rehman, S, Roth, G, Sebastian, I, Smith, A, Suwanwela, N, Sylaja, P, Thapa, R, Thrift, A, Uvere, E, Vollset, S, Yavagal, D, Yaria, J, Abera, S, Ibrahim, N, Liu, L, Ovbiagele, B, Piradov, M, Abanto, C, Addissie, A, Adeleye, A, Adilbekov, Y, Adilbekova, B, Adoukonou, T, Aguiar de Sousa, D, Akhmetzhanova, Z, Akpalu, A, El Alaoui-Faris, M, Ameriso, S, Andonova, S, Arsovska, A, Awoniyi, F, Bakhiet, M, Barboza, M, Basri, H, Bath, P, Bereczki, D, Beretta, S, Berkowitz, A, Bernhardt, J, Berzina, G, Bhavsar, B, Bisharyan, M, Bohara, M, Bovet, P, Budincevic, H, Cadilhac, D, Cerimagic, D, Charway-Felli, A, Chen, C, Chin, J, Christensen, H, Chwojnicki, K, Conforto, A, Correia, M, Mora Cuervo, D, Czlonkowska, A, D'Amelio, M, Danielyan, K, Davis, S, Demarin, V, Demchuk, A, Dichgans, M, Dokova, K, Donnan, G, Duran, J, Ekeng, G, Elkind, M, Endres, M, Fischer, U, Flomin, Y, Gankpe, F, Gavidia, M, Gaye Saavedra, A, Gebreyohanns, M, George, M, Gierlotka, M, Giroud, M, Gnedovskaya, E, Goncalves, I, Gongora-Rivera, F, Gunaratne, P, Hamadeh, R, Hamzat, T, Heldner, M, Ibrahim, E, Ihle-Hansen, H, Jee, S, Jiann-Shing, J, Johnston, S, Jovanovic, D, Jurjans, K, Kalani, R, Kalkonde, Y, Kamenova, S, Karaszewski, B, Kelly, P, Kiechl, S, Kondybayeva, A, Korv, J, Kozera, G, Kravchenko, M, Krespi, Y, Krishnamurthi, R, Kruja, J, Kutluk, K, Langhorne, P, Law, Z, Lebedynets, D, Lee, T, Leung, T, Liebeskind, D, Lopez-Jaramillo, P, Lotufo, P, Machline-Carrion, M, Maia, L, Malojcic, B, Markus, H, Marquez-Romero, J, Medina, M, Medukhanova, S, Mehndiratta, M, Miglane, E, Mihejeva, I, Mikulik, R, Mirrakhimov, E, Mohl, S, Munakomi, S, Murphy, S, Musa, K, Nasreldein, A, Nogueira, R, Nolte, C, Noubiap, J, Novarro-Escudero, N, Ocampo, C, O'Donnell, M, Ogun, Y, Ogunniyi, A, Oraby, M, Orken, D, Ozdemir, A, Ozturk, S, Paccot, M, Pereira, T, Peeters, A, Potpara, T, Proios, H, Rathore, F, Sacco, R, Sahathevan, R, Sandset, E, Renato Santos, I, Saposnik, G, Sarfo, F, Sargento-Freitas, J, Sharma, M, Shaw, L, Sheth, K, Shin, Y, Shobhana, A, Silva, S, Tedim Cruz, V, Thakur, K, Thapa, L, Toni, D, Topcuoglu, M, Torales, J, Towfighi, A, Truelsen, T, Tsiskaridze, A, Tulloch-Reid, M, Useche, J, Vanacker, P, Vassilopoulou, S, Vukorepa, G, Vuletic, V, Wahab, K, Wang, W, Wijeratne, T, Wojtyniak, B, Wolfe, C, Yacouba, M, Yang, J, Yifru, Y, Yock-Corrales, A, Yonemoto, N, Yperzeele, L, Zagozdzon, P, Feigin V. L., Owolabi M. O., Abd-Allah F., Akinyemi R. O., Bhattacharjee N. V., Brainin M., Cao J., Caso V., Dalton B., Davis A., Dempsey R., Duprey J., Feng W., Ford G. A., Gall S., Gandhi D., Good D. C., Hachinski V., Hacke W., Hankey G. J., Ishida M., Johnson W., Kim J., Lavados P., Lindsay P., Mahal A., Martins S., Murray C., Nguyen T. P., Norrving B., Olaiya M. T., Olalusi O. V., Pandian J., Phan H., Platz T., Ranta A., Rehman S., Roth G., Sebastian I. A., Smith A. E., Suwanwela N. C., Sylaja P. N., Thapa R., Thrift A. G., Uvere E., Vollset S. E., Yavagal D., Yaria J., Abera S. F., Akinyemi R., Dempsey R. J., Ibrahim N. M., Liu L., Ovbiagele B., Piradov M., Suwanwela N., Abanto C., Addissie A., Adeleye A. O., Adilbekov Y., Adilbekova B., Adoukonou T. A., Aguiar de Sousa D., Akhmetzhanova Z., Akpalu A., El Alaoui-Faris M., Ameriso S. F., Andonova S., Arsovska A., Awoniyi F. E., Bakhiet M., Barboza M. A., Basri H., Bath P. M., Bereczki D., Beretta S., Berkowitz A. L., Bernhardt J., Berzina G., Bhavsar B., Bisharyan M. S., Bohara M., Bovet P., Budincevic H., Cadilhac D. A., Cerimagic D., Charway-Felli A., Chen C., Chin J. H., Christensen H., Chwojnicki K., Conforto A. B., Correia M., Mora Cuervo D. L., Czlonkowska A., D'Amelio M., Danielyan K. E., Davis S., Demarin V., Demchuk A. M., Dichgans M., Dokova K., Donnan G., Duran J. C., Ekeng G., Elkind M. S., Endres M., Fischer U., Flomin Y., Gankpe F., Gavidia M., Gaye Saavedra A., Gebreyohanns M., George M., Gierlotka M., Giroud M., Gnedovskaya E. V., Goncalves I. P., Gongora-Rivera F., Gunaratne P. S., Hamadeh R. R., Hamzat T. -H. K., Heldner M. R., Ibrahim E., Ihle-Hansen H., Jee S., Jiann-Shing J., Johnston S. C., Jovanovic D., Jurjans K., Kalani R., Kalkonde Y., Kamenova S., Karaszewski B., Kelly P., Kiechl S., Kondybayeva A., Korv J., Kozera G., Kravchenko M., Krespi Y., Krishnamurthi R., Kruja J., Kutluk K., Langhorne P., Law Z. K., Lebedynets D., Lee T. -H., Leung T. W., Liebeskind D. S., Lopez-Jaramillo P., Lotufo P. A., Machline-Carrion M. J., Maia L. F., Malojcic B., Markus H. S., Marquez-Romero J. M., Medina M. T., Medukhanova S., Mehndiratta M. M., Miglane E., Mihejeva I., Mikulik R., Mirrakhimov E., Mohl S., Munakomi S., Murphy S., Musa K. I., Nasreldein A., Nogueira R. G., Nolte C. H., Noubiap J. J., Novarro-Escudero N., Ocampo C., O'Donnell M., Ogun Y., Ogunniyi A., Oraby M. I., Orken D. N., Ozdemir A. O., Ozturk S., Paccot M., Pereira T., Peeters A., Potpara T., Proios H., Rathore F. A., Sacco R. L., Sahathevan R., Sandset E. S., Renato Santos I., Saposnik G., Sarfo F. S., Sargento-Freitas J., Sharma M., Shaw L., Sheth K. N., Shin Y. -I., Shobhana A., Silva S. N., Tedim Cruz V., Thakur K., Thapa L. J., Toni D., Topcuoglu M. A., Torales J., Towfighi A., Truelsen T., Tsiskaridze A., Tulloch-Reid M., Useche J. N., Vanacker P., Vassilopoulou S., Vukorepa G., Vuletic V., Wahab K. W., Wang W., Wijeratne T., Wojtyniak B., Wolfe C., Yacouba M. N., Yang J., Yifru Y. M., Yock-Corrales A., Yonemoto N., Yperzeele L., and Zagozdzon P.
- Published
- 2023
27. Modeling Dipolar Post-Shock Accretion Columns for Various Specific Accretion Rate Intermediate Polars
- Author
-
Hayashi, T. and Ishida, M.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
We model the post-shock accretion column (PSAC) for intermediate polars (IPs), with parameterizing specific accretion rate between 0.0001 and 100 g cm-2 s-1 and metal abundance between 0.1 and 2 times of solar abundance, and taking into account the gravitational potential and non-equipartition between ions, electrons and ionization degree. We assume the cylinder and dipole as geometry of the PSAC. The PSAC becomes higher against the white dwarf (WD) radius for lower specific accretion rate and more massive WD, and may be comparable to the WD radius. The consideration of the dipolar geometry significantly reduces the density and temperature over the whole PSAC comparing with the cylindrical case when the specific accretion rate is lower than a threshold which the PSAC height reachs 0.2 RWD with and is decreased by the more massive white dwarf. We calculate the spectra of the cylindrical and dipolar PSACs with the wide range of the specific accretion rate. Although the spectra soften as the specific accretion rate decreases for the both geometrical assumptions under the specific accretion rate threshold, the softening is more speedy for the dipolar PSAC. The fact means that the both geometrical assumptions lead the different WD masses for each other when their spectra are applied to the IPs hosting the low accretion or a massive WD. Although the ionization non-equilibrium are also involved for the spectral calculation, the effects are trivial because the radiation from ionization non-equilibrium plasma is a few percent of the whole at most., Comment: submitted to MNRAS, 11 pages, 10 figures
- Published
- 2013
28. Observation of Longitudinal Spin Seebeck Effect with Various Transition Metal Films
- Author
-
Ishida, M., Kirihara, A., Someya, H., Uchida, K., Kohmoto, S., Saitoh, E., and Murakami, T.
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We evaluated the thermoelectric properties of longitudinal spin Seebeck devices by using ten different transition metals (TMs). Both the intensity and sign of spin Seebeck coefficients were noticeably dependent on the degree of the inverse spin Hall effect and the resistivity of each TM film. Spin dependent behaviors were also observed under ferromagnetic resonance. These results indicate that the output of the spin Seebeck devices originates in the spin current., Comment: 14 pages, 4 figures
- Published
- 2013
29. Searching for Stoponium along with the Higgs boson
- Author
-
Barger, V., Ishida, M., and Keung, W. -Y.
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
Stoponium, a bound state of top squark and its antiparticle in a supersymmetric model, may be found in the ongoing Higgs searches at the LHC. Its WW and ZZ detection ratios relative to the Standard Model Higgs boson can be more than unity from WW* threshold to the two Higgs threshold. The gamma gamma channel is equally promising. Some regions of the stoponium mass below 150 GeV are already being probed by the ATLAS and CMS experiments., Comment: 10 pages 5 figures
- Published
- 2011
- Full Text
- View/download PDF
30. X-ray observation of AM Herculis in a very low state with Suzaku
- Author
-
Terada, Y., Ishida, M., Bamba, A., Mukai, K., Hayashi, T., and Harayama, A.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
The X-ray observation of AM Her in a very low state was performed with {\it Suzaku} in October 2008. One flare event with a time scale of $\sim$ 3700 sec was detected at the X-ray luminosity of $6.0 \times 10^{29} {\rm ~erg ~sec}^{-1}$ in the 0.5 -- 10 keV band assuming at a distance of 91 pc. The X-ray spectrum is represented by a thermal plasma emission model with a temperature of $8.67_{-1.14}^{+1.31}$ keV. During the quiescence out of the flare interval, {\it Suzaku} also detected significant X-rays at a luminosity of $1.7 \times 10^{29} {\rm ~erg ~sec}^{-1}$ in the 0.5 -- 10 keV band, showing a clear spin modulation at a period of 0.1289273(2) days at BJD 2454771.581. The X-ray spectra in the quiescence were represented by a MEKAL + Power Law (PL) model or a single CEMEKL model, which are also supported by phase-resolved analyses. A correlation between the temperature and the volume emission measure was found together with historical X-ray measurements of AM Her in various states. In order to account for a possible non-thermal emission from AM Her, particle acceleration mechanisms in the AM Her system are also discussed, including a new proposal of a shock acceleration process on the top of the accretion column., Comment: 16 pages, 9 figures, 4 tables, Accepted for publication in Astrophysical Journal
- Published
- 2010
- Full Text
- View/download PDF
31. Suzaku X-Ray Imaging and Spectroscopy of Cassiopeia A
- Author
-
Maeda, Y., Uchiyama, Y., Bamba, A., Kosugi, H., Tsunemi, H., Helder, E. A., Vink, J., Kodaka, N., Terada, Y., Fukazawa, Y., Hiraga, J., Hughes, J. P., Kokubun, M., Kouzu, T., Matsumoto, H., Miyata, E., Nakamura, R., Okada, S., Someya, K., Tamagawa, T., Tamura, K., Totsuka, K., Tsuboi, Y., Ezoe, Y., Holt, S. S., Ishida, M., Kamae, T., Petre, R., and Takahashi, T.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
Suzaku X-ray observations of a young supernova remnant, Cassiopeia A, were carried out. K-shell transition lines from highly ionized ions of various elements were detected, including Chromium (Cr-Kalpha at 5.61 keV). The X-ray continuum spectra were modeled in the 3.4--40 keV band, summed over the entire remnant, and were fitted with a simplest combination of the thermal bremsstrahlung and the non-thermal cut-off power-law models. The spectral fits with this assumption indicate that the continuum emission is likely to be dominated by the non-thermal emission with a cut-off energy at > 1 keV. The thermal-to-nonthermal fraction of the continuum flux in the 4-10 keV band is best estimated as ~0.1. Non-thermal-dominated continuum images in the 4--14 keV band were made. The peak of the non-thermal X-rays appears at the western part. The peak position of the TeV gamma-rays measured with HEGRA and MAGIC is also shifted at the western part with the 1-sigma confidence. Since the location of the X-ray continuum emission was known to be presumably identified with the reverse shock region, the possible keV-TeV correlations give a hint that the accelerated multi-TeV hadrons in Cassiopeia A are dominated by heavy elements in the reverse shock region., Comment: Publ. Astron. Soc. Japan 61, pp.1217-1228 (2009)
- Published
- 2009
- Full Text
- View/download PDF
32. Broad-band properties of the hard X-ray cataclysmic variables IGR J00234+6141 and 1RXS J213344.1+510725
- Author
-
Anzolin, G., de Martino, D., Falanga, M., Mukai, K., Bonnet-Bidaud, J. -M., Mouchet, M., Terada, Y., and Ishida, M.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
A significant number of cataclysmic variables were detected as hard X-ray sources in the INTEGRAL survey, most of them of the magnetic intermediate polar type. We present a detailed X-ray broad-band study of two new sources, IGR J00234+6141 and 1RXS J213344.1+510725, that allow us to classify them as secure members of the intermediate polar class. Timing and spectral analysis of IGR J00234+6141 are based on a XMM-Newton observation and INTEGRAL publicly available data. For 1RXS J213344.1+510725 we use XMM-Newton and Suzaku observations at different epochs, as well as INTEGRAL publicly available data. We determine a spin period of 561.64 +/- 0.56 s for the white dwarf in IGR J00234+6141. The X-ray pulses are observed up to about 2 keV. From XMM-Newton and Suzaku observations of 1RXS J213344.1+510725, we find a rotational period of 570.862 +/- 0.034 s. The observations span three epochs where the pulsation is observed to change at different energies both in amplitude and shape. In both objects, the spectral analysis spanned over a wide energy range, from 0.3 to 100 keV, shows the presence of multiple emission components absorbed by dense material. The X-ray spectrum of IGR J00234+6141 is consistent with a multi-temperature plasma with a maximum temperature of about 50 keV. In 1RXS J213344.1+510725, multiple optically thin components are inferred, as well as an optically thick (blackbody) soft X-ray emission with a temperature of about 100 eV. This latter adds 1RXS J213344.1+510725 to the growing group of soft X-ray intermediate polars. (abridged), Comment: 12 pages, 8 figures, 5 tables. Accepted for publication in A&A
- Published
- 2009
- Full Text
- View/download PDF
33. Inferior vena cava wall thickness is associated with the presence and severity of cardiovascular disease
- Author
-
Fujiyoshi, K, primary, Tojo, T, additional, Ishida, K, additional, Ishida, M, additional, Yamaoka-Tojo, M, additional, and Ako, J, additional
- Published
- 2023
- Full Text
- View/download PDF
34. EP06.06-09 Clinical Significance of the Presence of MECA-79-Positive Tumor Cells in Pathological Stage IA Invasive Adenocarcinoma of the Lung
- Author
-
Saito, T., primary, Ishida, M., additional, Akama, T., additional, Suzuki, M., additional, Hanaoka, H., additional, Takahashi, H., additional, Maru, N., additional, Utsumi, T., additional, Matsui, H., additional, Taniguchi, Y., additional, Hino, H., additional, and Murakawa, T., additional
- Published
- 2023
- Full Text
- View/download PDF
35. Scaling slowly rotating asteroids with stellar occultations
- Author
-
Marciniak, A., primary, Ďurech, J., additional, Choukroun, A., additional, Hanuš, J., additional, Ogłoza, W., additional, Szakáts, R., additional, Molnár, L., additional, Pál, A., additional, Monteiro, F., additional, Frappa, E., additional, Beisker, W., additional, Pavlov, H., additional, Moore, J., additional, Adomavičienė, R., additional, Aikawa, R., additional, Andersson, S., additional, Antonini, P., additional, Argentin, Y., additional, Asai, A., additional, Assoignon, P., additional, Barton, J., additional, Baruffetti, P., additional, Bath, K. L., additional, Behrend, R., additional, Benedyktowicz, L., additional, Bernasconi, L., additional, Biguet, G., additional, Billiani, M., additional, Błażewicz, D., additional, Boninsegna, R., additional, Borkowski, M., additional, Bosch, J., additional, Brazill, S., additional, Bronikowska, M., additional, Bruno, A., additional, Butkiewicz-Bąk, M., additional, Caron, J., additional, Casalnuovo, G., additional, Castellani, J. J., additional, Ceravolo, P., additional, Conjat, M., additional, Delincak, P., additional, Delpau, J., additional, Demeautis, C., additional, Demirkol, A., additional, Dróżdż, M., additional, Duffard, R., additional, Durandet, C., additional, Eisfeldt, D., additional, Evangelista, M., additional, Fauvaud, S., additional, Fauvaud, M., additional, Ferrais, M., additional, Filipek, M., additional, Fini, P., additional, Fukui, K., additional, Gährken, B., additional, Geier, S., additional, George, T., additional, Goffin, B., additional, Golonka, J., additional, Goto, T., additional, Grice, J., additional, Guhl, K., additional, Halíř, K., additional, Hanna, W., additional, Harman, M., additional, Hashimoto, A., additional, Hasubick, W., additional, Higgins, D., additional, Higuchi, M., additional, Hirose, T., additional, Hirsch, R., additional, Hofschulz, O., additional, Horaguchi, T., additional, Horbowicz, J., additional, Ida, M., additional, Ignácz, B., additional, Ishida, M., additional, Isobe, K., additional, Jehin, E., additional, Joachimczyk, B., additional, Jones, A., additional, Juan, J., additional, Kamiński, K., additional, Kamińska, M. K., additional, Kankiewicz, P., additional, Kasebe, H., additional, Kattentidt, B., additional, Kim, D.-H., additional, Kim, M.-J., additional, Kitazaki, K., additional, Klotz, A., additional, Komraus, M., additional, Konstanciak, I., additional, Könyves-Tóth, R., additional, Kouno, K., additional, Kowald, E., additional, Krajewski, J., additional, Krannich, G., additional, Kreutzer, A., additional, Kryszczyńska, A., additional, Kubánek, J., additional, Kudak, V., additional, Kugel, F., additional, Kukita, R., additional, Kulczak, P., additional, Lazzaro, D., additional, Licandro, J., additional, Livet, F., additional, Maley, P., additional, Manago, N., additional, Mánek, J., additional, Manna, A., additional, Matsushita, H., additional, Meister, S., additional, Mesquita, W., additional, Messner, S., additional, Michelet, J., additional, Michimani, J., additional, Mieczkowska, I., additional, Morales, N., additional, Motyliński, M., additional, Murawiecka, M., additional, Newman, J., additional, Nikitin, V., additional, Nishimura, M., additional, Oey, J., additional, Oszkiewicz, D., additional, Owada, M., additional, Pakštienė, E., additional, Pawłowski, M., additional, Pereira, W., additional, Perig, V., additional, Perła, J., additional, Pilcher, F., additional, Podlewska-Gaca, E., additional, Polák, J., additional, Polakis, T., additional, Polińska, M., additional, Popowicz, A., additional, Richard, F., additional, Rives, J. J, additional, Rodrigues, T., additional, Rogiński, Ł., additional, Rondón, E., additional, Rottenborn, M., additional, Schäfer, R., additional, Schnabel, C., additional, Schreurs, O., additional, Selva, A., additional, Simon, M., additional, Skiff, B., additional, Skrutskie, M., additional, Skrzypek, J., additional, Sobkowiak, K., additional, Sonbas, E., additional, Sposetti, S., additional, Stuart, P., additional, Szyszka, K., additional, Terakubo, K., additional, Thomas, W., additional, Trela, P., additional, Uchiyama, S., additional, Urbanik, M., additional, Vaudescal, G., additional, Venable, R., additional, Watanabe, Ha., additional, Watanabe, Hi., additional, Winiarski, M., additional, Wróblewski, R., additional, Yamamura, H., additional, Yamashita, M., additional, Yoshihara, H., additional, Zawilski, M., additional, Zelený, P., additional, Żejmo, M., additional, Żukowski, K., additional, and Żywica, S., additional
- Published
- 2023
- Full Text
- View/download PDF
36. EP06.02-05 Agreement among Programmed Cell Death Ligand-1 Immunohistochemistry Results Using 73-10, 22C3 and 28-8 Antibodies for Lung Cancer
- Author
-
Saito, T., primary, Ishida, M., additional, Takeyasu, Y., additional, Utsumi, T., additional, Maru, N., additional, Matsui, H., additional, Taniguchi, Y., additional, Hino, H., additional, Kurata, T., additional, and Murakawa, T., additional
- Published
- 2023
- Full Text
- View/download PDF
37. The NeXT Mission
- Author
-
Takahashi, T., Kelley, R., Mitsuda, K., Kunieda, H., Petre, R., White, N., Dotani, T., Fujimoto, R., Fukazawa, Y., Hayashida, K., Ishida, M., Ishisaki, Y., Kokubun, M., Makishima, K., Koyama, K., Madejski, G. M., Mori, K., Mushotzky, R., Nakazawa, K., Ogasaka, Y., Ohashi, T., Ozaki, M., Tajima, H., Tashiro, M., Terada, Y., Tsunemi, H., Tsuru, T. G., Ueda, Y., Yamasaki, N., Watanabe, S., and team, the NeXT
- Subjects
Astrophysics - Abstract
The NeXT (New exploration X-ray Telescope), the new Japanese X-ray Astronomy Satellite following Suzaku, is an international X-ray mission which is currently planed for launch in 2013. NeXT is a combination of wide band X-ray spectroscopy (3 - 80 keV) provided by multi-layer coating, focusing hard X-ray mirrors and hard X-ray imaging detectors, and high energy-resolution soft X-ray spectroscopy (0.3 - 10 keV) provided by thin-foil X-ray optics and a micro-calorimeter array. The mission will also carry an X-ray CCD camera as a focal plane detector for a soft X-ray telescope and a non-focusing soft gamma-ray detector. With these instruments, NeXT covers very wide energy range from 0.3 keV to 600 keV. The micro-calorimeter system will be developed by international collaboration lead by ISAS/JAXA and NASA. The simultaneous broad bandpass, coupled with high spectral resolution of Delta E ~ 7 eV by the micro-calorimeter will enable a wide variety of important science themes to be pursued., Comment: 14 pages, 10 figures, Proceedings of the SPIE meeting, "Space Telescopes and Instrumentation II: Ultraviolet to Gamma Ray 2008", Marseille (2008)
- Published
- 2008
- Full Text
- View/download PDF
38. Efficacy and safety of controlled-release oxycodone for the management of moderate-to-severe chronic low back pain in Japan: results of an enriched enrollment randomized withdrawal study followed by an open-label extension study
- Author
-
Kawamata M, Iseki M, Kawakami M, Yabuki S, Sasaki T, Ishida M, Nishiyori A, Hida H, and Kikuchi S
- Subjects
chronic low back pain ,opioids ,oxycodone ,Medicine (General) ,R5-920 - Abstract
Mikito Kawamata,1 Masako Iseki,2 Mamoru Kawakami,3 Shoji Yabuki,4 Takuma Sasaki,5 Mitsuhiro Ishida,5 Atsushi Nishiyori,5 Hideaki Hida,6 Shin-ichi Kikuchi4 1Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Japan; 2Department of Anesthesiology and Pain Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan; 3Spine Care Center, Wakayama Medical University Kihoku Hospital, Wakayama, Japan; 4Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan; 5Clinical Development Department, Shionogi & Co. Ltd., Osaka, Japan; 6Biostatistics Center, Shionogi & Co. Ltd., Osaka, Japan Background: Oxycodone is one of the options for the management of CLBP in patients with an inadequate response to other analgesics. However, oxycodone is not yet approved for noncancer pain in Japan. Here, we assessed the efficacy and long-term safety of S-8117, a controlled-release oxycodone formulation, for the management of Japanese CLBP patients. Patients and methods: An initial enriched enrollment randomized withdrawal, double-blind, placebo-controlled, 5-week phase III trial was conducted across 54 centers in Japan to assess the efficacy of S-8117 vs placebo in moderate-to-severe CLBP patients. Subsequently, a 52-week, open-label, single-arm study was conducted across 53 centers in Japan to evaluate the long-term safety of S-8117. The primary endpoint was the time to inadequate analgesic response during 35 days of the double-blind period. Secondary endpoints were the percentages of patients with inadequate analgesic response, discontinuation rate due to inadequate analgesic effects or AEs, and changes in scores of BPI severity, BPI pain interference, SF-36, and Roland-Morris Disability Questionnaire. Safety was assessed as the incidence of AEs and ADRs. Results: Of the 189 patients enrolled in the double-blind study, 130 patients who completed the initial titration period were randomized 1:1 to receive either S-8117 (n=62) or placebo (n=68). Baseline characteristics were comparable across the study groups. The time to inadequate analgesic response was significantly longer in patients treated with S-8117 than placebo (P=0.0095). Secondary endpoints corroborated the efficacy of S-8117 vs placebo. Overall, 478 AEs were reported in 73/75 patients in the long-term study. The most frequent ADRs were somnolence, constipation, and nausea. No case of drug dependence was reported in the long-term study. Conclusion: Short-term efficacy vs placebo and long-term safety of S-8117 were demonstrated for the management of Japanese patients with moderate-to-severe CLBP. Keywords: chronic low back pain, opioids, oxycodone, RCT
- Published
- 2019
39. An Integrated FEM Model System of the Craniofacial Complex Applied to Biomechanical Research in Orthodontics
- Author
-
Tanne, K., primary, Matsubara, S., additional, Sasaki, A., additional, and Ishida, M., additional
- Published
- 2020
- Full Text
- View/download PDF
40. Clinical characteristics and outcomes in Japanese patients with COPD according to the 2017 GOLD classification: the Ishinomaki COPD Network Registry
- Author
-
Kobayashi S, Hanagama M, Ishida M, Sato H, Ono M, Yamanda S, Yamada M, Aizawa H, and Yanai M
- Subjects
COPD ,GOLD ,GOLD 2017 ,exacerbations ,mortality ,Diseases of the respiratory system ,RC705-779 - Abstract
Seiichi Kobayashi,1 Masakazu Hanagama,1 Masatsugu Ishida,1 Hikari Sato,1 Manabu Ono,1 Shinsuke Yamanda,1 Mitsuhiro Yamada,2 Hiroyuki Aizawa,1 Masaru Yanai1 1Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan; 2Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan Purpose: The GOLD report provides a framework for classifying COPD in a way that reflects its clinical impact and allows treatment recommendations. The GOLD 2017 proposes a new classification whereby patients are grouped as A–D according to their symptoms and history of exacerbations. However, the clinical characteristics and outcomes in these patients are not well documented.Patients and methods: In this prospective observational study, we analyzed data from the Ishinomaki COPD Network Registry. All patients with stable COPD were classified into the four groups defined by GOLD 2017. The patient demographics, clinical characteristics, number of exacerbations, and mortality rate during 1 year of follow-up were compared between the groups.Results: Four hundred and one patients with stable COPD were identified. There were 240 patients (59.9%) in group A, 122 (30.4%) in group B, 16 (4.0%) in group C, and 23 (5.7%) in group D. Patients in groups B, C, and D had ORs of 2.95, 3.92, and 5.45, respectively, for risk of exacerbation relative to group A. Groups C and D experienced exacerbations more frequently, including exacerbations leading to hospital admission, than groups A and B (both P
- Published
- 2018
41. DIOS: the Diffuse Intergalactic Oxygen Surveyor
- Author
-
Ohashi, T., Ishida, M., Sasaki, S., Ishisaki, Y., Mitsuda, K., Yamasaki, N. Y., Fujimoto, R., Takei, Y., Tawara, Y., Furuzawa, A., Suto, Y., Yoshikawa, K., Kawahara, H., Kawai, N., Tsuru, T. G., Matsushita, K., and Kitayama, T.
- Subjects
Astrophysics - Abstract
We present our proposal for a small X-ray mission DIOS (Diffuse Intergalactic Oxygen Surveyor), consisting of a 4-stage X-ray telescope and an array of TES microcalorimeters, cooled with mechanical coolers, with a total weight of about 400 kg. The mission will perform survey observations of warm-hot intergalactic medium using OVII and OVIII emission lines, with the energy coverage up to 1.5 keV. The wide field of view of about 50' diameter, superior energy resolution close to 2 eV FWHM, and very low background will together enable us a wide range of science for diffuse X-ray sources. We briefly describe the design of the satellite, performance of the subsystems and the expected results., Comment: 9 pages, 11 figures, a proceedings of SPIE "Astronomical Telescopes and Instrumentation" 2006
- Published
- 2006
- Full Text
- View/download PDF
42. XMM-Newton Observation of IC 310 in the Outer Region of the Perseus Cluster of Galaxies
- Author
-
Sato, K., Furusho, T., Yamasaki, N. Y., Ishida, M., Matsushita, K., and Ohashi, T.
- Subjects
Astrophysics - Abstract
We present results from an XMM-Newton observation of the head-tail radio galaxy IC 310 located in the southwest region of the Perseus cluster. The spectrum is well-fitted by an absorbed power-law model with a photon index of $2.50 \pm 0.02$ with no significant absorption excess. The X-ray image shows a point-like emission at IC 310 without any signs of a structure correlated with the radio halo tail. The temperature of the intracluster medium surrounding IC 310 declines as a function of distance from the cluster center, from $ kT \sim 6$ keV in the northeast corner of the field of view to about 3 keV in the southwest region. Although we do not find any sharp edges in the surface brightness profile, a brightness excess over a smooth $\beta$ model by about 20% is seen. The temperature also rises by about 10% in the same region. This indicates that the IC 310 region is a subcluster probably infalling into the Perseus cluster, and the gas in front of IC 310 towards the Perseus cluster is likely to be compressed by the large-scale motion, which supports the view that the IC 310 system is undergoing a merger., Comment: 7 pages, 8 figures (including color), accepted for publication in PASJ
- Published
- 2005
- Full Text
- View/download PDF
43. The role of imprinted genes in human fetal growth
- Author
-
Ishida, M.
- Subjects
576.5 - Abstract
Identifying the genes important for fetal growth will help to understand common, serious complications of pregnancy such as intrauterine growth restriction (IUGR). Of particular interest are imprinted genes, which show monoallelic, parent-of-origin specific expression. Genes that are paternally derived tend to enhance fetal growth whereas maternally expressed genes suppress growth. A significant correlation between lower birth weight and increased expression of maternally expressed, pleckstrin homology-like domain, family A, member 2 (PHLDA2) in term placenta, without loss of imprinting, had been reported previously. We have identified a novel copy number variant (CNV1) in the PHLDA2 promoter which reduced the promoter efficiency in a luciferase reporter gene assay. Meta-analysis of CNV1 genotype data obtained from three independent white European normal birth cohorts (total n = 9,433) showed that maternal inheritance of CNV1 resulted in a 93 g increase in birth weight (P = 0.01). Moreover, when the mother was homozygous for CNV1, the influence on birth weight was 155 g (P = 0.04), a similar magnitude to the reduction caused by maternal smoking. The expression levels of paternally expressed gene 3 (PEG3), delta-like 1 homolog (DLK1) and maternally expressed gene 3 (MEG3) measured by real-time PCR in >110 normal term placentas from a white European cohort did not show correlation with fetal birth size measurements, except for a trend of positive association observed for DLK1 expression and birth weight (P = 0.072). Paternal inheritance of the type 1 diabetes (T1D) protective G allele of rs941576 SNP located in the DLK1-MEG3 locus was shown to be associated with a 132 g (P = 0.011) and 0.5 cm (P = 0.011) reduction in birth weight and head circumference respectively. This newly described PHLDA2 promoter CNV and rs941576 SNP, alongside their expressions, may provide useful genetic biomarkers/indicators for predicting birth size.
- Published
- 2012
44. Hyperactivité vésicale chez le patient gériatrique hospitalisé : une approche structurée
- Author
-
Lang, P.O., Ishida, M., Akrour, R., and Schurch, B.
- Published
- 2018
- Full Text
- View/download PDF
45. Locating the Warm-Hot Intergalactic Medium in the Simulated Local Universe
- Author
-
Yoshikawa, K., Dolag, K., Suto, Y., Sasaki, S., Yamasaki, N. Y., Ohashi, T., Mitsuda, K., Tawara, Y., Fujimoto, R., Furusho, T., Furuzawa, A., Ishida, M., Ishisaki, Y., and Takei, Y.
- Subjects
Astrophysics - Abstract
We present an analysis of mock spectral observation of warm-hot intergalactic medium (WHIM) using a constrained simulation of the local universe. The simulated map of oxygen emission lines from local WHIM reproduces well the observed structures traced by galaxies in the real local universe. We further attempt to perform mock observations of outer parts of simulated Coma cluster and A3627 adopting the expected performance of DIOS (Diffuse Intergalactic Oxygen Surveyor), which is proposed as a dedicated soft X-ray mission to search for cosmic missing baryons. We find that WHIMs surrounding nearby clusters are detectable with a typical exposure time of a day, and thus constitute realistic and promising targets for DIOS. We also find that an X-ray emitting clump in front of Coma cluster, recently reported in the XMM-Newton observation, has a counterpart in the simulated local universe, and its observed spectrum can be well reproduced in the simulated local universe if the gas temperature is set to the observationally estimated value., Comment: 25 pages, 3 tables, 16 figures. Accepted for publication in PASJ. High resolution PS/PDF files are available at http://www-utap.phys.s.u-tokyo.ac.jp/~kohji/research/x-ray/index.html
- Published
- 2004
- Full Text
- View/download PDF
46. Future Japanese missions for the study of warm-hot intergalactic medium
- Author
-
Ohashi, T., Ishida, M., Sasaki, S., Ishisaki, Y., Mitsuda, K., Yamasaki, N. Y., Fujimoto, R., Furusho, T., Kunieda, H., Tawara, Y., Furuzawa, A., Suto, Y., and Yoshikawa, K.
- Subjects
Astrophysics - Abstract
We present our proposal for a small X-ray mission DIOS (Diffuse Intergalactic Oxygen Surveyor) to perform survey observations of warm-hot intergalactic medium using OVII and OVIII emission lines. This will be proposed to a small satellite program planned by ISAS/JAXA in Japan for a launch in 2008. The instrument consists of an array of TES microcalorimeters with an energy resolution 2 eV, cooled by mechanical coolers. The X-ray telescope will employ 4-stage reflection mirrors with a focal length as short as 70 cm and an angular resolution 2'. In addition to DIOS, we briefly describe the NeXT (New X-ray Telescope) mission, which is a larger Japanese X-ray observatory to be launched in 2010 and plans to explore non-thermal processes in the universe., Comment: 6 pages, 9 figures. To appear in the proceedings of "Modelling the Intergalactic and Intracluster Media", Vulcano Island, October 1-4, 2003
- Published
- 2004
47. Study on Novel Topology of Solar–Wind Hybrid Power Plant Using Photovoltaic Cell Emulating System
- Author
-
Phap, Vu Minh, Yamamura, N., Ishida, M., Nga, Nguyen Thuy, Mizoguchi, I., and Yamashita, T.
- Published
- 2019
- Full Text
- View/download PDF
48. Resolve Instrument on X-ray Astronomy Recovery Mission (XARM)
- Author
-
Ishisaki, Y., Ezoe, Y., Yamada, S., Ichinohe, Y., Fujimoto, R., Takei, Y., Yasuda, S., Ishida, M., Yamasaki, N. Y., Maeda, Y., Tsujimoto, M., Iizuka, R., Koyama, S., Noda, H., Tamagawa, T., Sawada, M., Sato, K., Kitamoto, S., Hoshino, A., Brown, G. V., Eckart, M. E., Hayashi, T., Kelley, R. L., Kilbourne, C. A., Leutenegger, M. A., Mori, H., Okajima, T., Porter, F. S., Soong, Y., McCammon, D., Szymkowiak, A. E., and The XARM Resolve Team
- Published
- 2018
- Full Text
- View/download PDF
49. X-Ray Beaming due to Resonance Scattering in the Accretion Column of Magnetic Cataclysmic Variables
- Author
-
Terada, Yukikatsu., Ishida, M., Makishima, K., Imanari, T., Fujimoto, R., Matsuzaki, K., and Kaneda, H.
- Subjects
Astrophysics - Abstract
Extremely strong ionized Fe emission lines, with the equivalent width reaching about 4000 eV, were discovered with ASCA from a few Galactic compact objects, including AX J2315-0592, RX J1802.1+1804 and AX J1842.8-0423. These objects are thought to be binary systems containing magnetized white dwarfs (WDs). A possible interpretation of the strong Fe-K line is the line-photon collimation in the WD accretion column, due to resonance scattering of line photons. The collimation occurs when the accretion column has a flat shape, and the effect is augmented by the vertical velocity gradient there, which reduces the resonant trapping of resonant photons along the magnetic field lines. This effect was quantitatively confirmed with Monte-Carlo simulations. Furthermore, with ASCA observations of the polar V834 Centauri, this collimation effect was clearly detected as a rotational modulation of the equivalent width of the Fe-K emission line. Extremely strong emission lines mentioned above can be explained by our interpretation consistently. Combing this effect with other X-ray information, the geometry and plasma parameters in the accretion column were determined., Comment: 16 pages, Postscript, 32 figures, and 4 tables; accepted for MNRAS (Monthly Notices of The Royal Astronomical Society) on July 24, 2001
- Published
- 2001
- Full Text
- View/download PDF
50. Temperature Map of the Virgo Cluster of Galaxies Observed with ASCA
- Author
-
Shibata, R., Matsushita, K., Yamasaki, N. Y., Ohashi, T., Ishida, M., Kikuchi, K., Boehringer, H., and Matsumoto, H.
- Subjects
Astrophysics - Abstract
The temperature distribution of the intracluster medium (ICM) in the Virgo cluster of galaxies has been derived from extensive mapping observations with ASCA covering an area of 19 deg^2. In the spectral analysis, the inner region within a radius of ~60' from M87 is characterized by an ICM temperature of kT \~2.5 keV with little variation. On the other hand, the outer regions indicate significant variation of the temperature with an amplitude of about 1 keV. The temperature map was produced from the hardness ratio (H.R.) values with a resolution of about 5'. Besides the previously reported hot region with kT > 4 keV between M87 and M49, several hot regions with kT = 3-4 keV are detected in the cluster outskirts. The auto-correlation function for the H.R. variation shows that the temperature variation is correlated within a size of about 300 kpc, suggesting that gas blobs falling in the Virgo cluster have a typical size of groups of galaxies. A correlation with the velocity dispersion of member galaxies shows that only the north-west region indicates an unusually large beta_spec value of 2-4. The upper limit for extended non-thermal emission in the Virgo cluster is obtained to be L_X ~9 x 10^41 ergs/s in the 2 - 10 keV band. We discuss that these features consistently indicate that the Virgo cluster is in a relatively early stage of the cluster evolution., Comment: 37 pages, including 12 Postscript figures, accepted for publication in ApJ
- Published
- 2000
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.