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11 results on '"Ishibashi, Minaka"'

1. Stress-impaired reward pathway promotes distinct feeding behavior patterns

Author

Fujioka, Yusuke, primary, Kawai, Kaori, additional, Endo, Kuniyuki, additional, Ishibashi, Minaka, additional, Iwade, Nobuyuki, additional, Tuerde, Dilina, additional, Kaibuchi, Kozo, additional, Yamashita, Takayuki, additional, Yamanaka, Akihiro, additional, Katsuno, Masahisa, additional, Watanabe, Hirohisa, additional, Sobue, Gen, additional, and Ishigaki, Shinsuke, additional

Published
2024
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2. Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene

Author

Ishibashi, Minaka, Manning, Elizabeth, Shoubridge, Cheryl, Krecsmarik, Monika, Hawkins, Thomas A., Giacomotto, Jean, Zhao, Ting, Mueller, Thomas, Bader, Patricia I., Cheung, Sau W., Stankiewicz, Pawel, Bain, Nicole L., Hackett, Anna, Reddy, Chilamakuri C. S., Mechaly, Alejandro S., Peers, Bernard, Wilson, Stephen W., Lenhard, Boris, Bally-Cuif, Laure, Gecz, Jozef, Becker, Thomas S., and Rinkwitz, Silke

Published
2015
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3. Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases

Author

Ishigaki, Shinsuke, Riku, Yuichi, Fujioka, Yusuke, Endo, Kuniyuki, Iwade, Nobuyuki, Kawai, Kaori, Ishibashi, Minaka, Yokoi, Satoshi, Katsuno, Masahisa, Watanabe, Hirohisa, Mori, Keiko, Akagi, Akio, Yokota, Osamu, Terada, Seishi, Kawakami, Ito, Suzuki, Naoki, Warita, Hitoshi, Aoki, Masashi, Yoshida, Mari, and Sobue, Gen

Subjects
SFPQ, mental disorders, nutritional and metabolic diseases, FTLD, nervous system diseases, FUS
Abstract

Fused in sarcoma (FUS) is genetically and clinicopathologically linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). We have previously reported that intranuclear interactions of FUS and splicing factor, proline- and glutamine-rich (SFPQ) contribute to neuronal homeostasis. Disruption of the FUS-SFPQ interaction leads to an increase in the ratio of 4-repeat tau (4R-tau)/3-repeat tau (3R-tau), which manifests in FTLD-like phenotypes in mice. Here, we examined FUS-SFPQ interactions in 142 autopsied individuals with FUS-related ALS/FTLD (ALS/FTLD-FUS), TDP-43-related ALS/FTLD (ALS/FTLD-TDP), progressive supranuclear palsy, corticobasal degeneration, Alzheimer’s disease, or Pick’s disease as well as controls. Immunofluorescent imaging showed impaired intranuclear co-localization of FUS and SFPQ in neurons of ALS/FTLD-FUS, ALS/FTLD-TDP, progressive supranuclear palsy and corticobasal degeneration cases, but not in Alzheimer’s disease or Pick’s disease cases. Immunoprecipitation analyses of FUS and SFPQ revealed reduced interactions between the two proteins in ALS/FTLD-TDP and progressive supranuclear palsy cases, but not in those with Alzheimer disease. Furthermore, the ratio of 4R/3R-tau was elevated in cases with ALS/FTLD-TDP and progressive supranuclear palsy, but was largely unaffected in cases with Alzheimer disease. We concluded that impaired interactions between intranuclear FUS and SFPQ and the subsequent increase in the ratio of 4R/3R-tau constitute a common pathogenesis pathway in FTLD spectrum diseases., ファイル公開日: 2021/08/08

Published
2020

4. Stress-impaired reward pathway promotes distinct feeding behavior patterns

Author

Fujioka, Yusuke, primary, Kawai, Kaori, additional, Endo, Kuniyuki, additional, Ishibashi, Minaka, additional, Iwade, Nobuyuki, additional, Tuerde, Dilina, additional, Kaibuchi, Kozo, additional, Yamashita, Takayuki, additional, Yamanaka, Akihiro, additional, Katsuno, Masahisa, additional, Watanabe, Hirohisa, additional, Ishigaki, Shinsuke, additional, and Sobue, Gen, additional

Published
2021
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5. Tau isoform expression and phosphorylation in marmoset brains

Author

Sharma, Govinda, primary, Huo, Anni, additional, Kimura, Taeko, additional, Shiozawa, Seiji, additional, Kobayashi, Reona, additional, Sahara, Naruhiko, additional, Ishibashi, Minaka, additional, Ishigaki, Shinsuke, additional, Saito, Taro, additional, Ando, Kanae, additional, Murayama, Shigeo, additional, Hasegawa, Masato, additional, Sobue, Gen, additional, Okano, Hideyuki, additional, and Hisanaga, Shin-ichi, additional

Published
2019
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6. Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome

Author

Naville, Magali, Ishibashi, Minaka, Ferg, Marco, Bengani, Hemant, Rinkwitz, Silke, Krecsmarik, Monika, Hawkins, Thomas A., Wilson, Stephen W., Manning, Elizabeth, Chilamakuri, Chandra S. R., Wilson, David I., Louis, Alexandra, Lucy Raymond, F., Rastegar, Sepand, Strähle, Uwe, Lenhard, Boris, Bally-Cuif, Laure, van Heyningen, Veronica, FitzPatrick, David R., Becker, Thomas S., Roest Crollius, Hugues, Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Brain and Mind Research Institute, University of Technology Sydney (UTS), Karlsruhe Institute of Technology (KIT), MRC Human Genetics Unit, MRC Institute of Medical Genetic and Molecular Medicine, Institut des Neurosciences de Paris-Saclay (Neuro-PSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), C.D.B. Division of Biosciences, Anatomy building UCL, Department of Tumor Biology, The Norwegian Radium Hospital, University of Southampton and University Hospital Southampton NHS Foundation Trust, Centre for Human Development, Stem Cells and Regeneration, MP808, Faculty of Medicine, Cambridge Institute for Medical Research (CIMR), University of Cambridge [UK] (CAM), Institute of Clinical Sciences, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, University of Bergen (UIB), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Paris-Saclay (NeuroPSI), University of Bergen (UiB), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris

Subjects
Life sciences, biology, Genetic Linkage, DATABASE, Evolution, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Gene Expression, Article, DISEASE, Animals, Genetically Modified, Evolution, Molecular, Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714 [VDP], Medisinske Fag: 700 [VDP], ddc:570, ELEMENTS, Genetics, Animals, Humans, Selection, Genetic, Zebrafish, GENE-EXPRESSION, Gene Rearrangement, TOOLS, Chromosomes, Human, X, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, GENOMIC SEQUENCES, IN-SITU HYBRIDIZATION, ENHANCERS, Biological sciences, Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714 [VDP], Enhancer Elements, Genetic, HUMAN CELL-TYPES, CONSERVED SYNTENY
Abstract

Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage. Here we test this concept experimentally using the human X chromosome. We describe a scoring method to identify evolutionary maintenance of linkage between conserved noncoding elements and neighbouring genes. Chromatin marks associated with enhancer function are strongly correlated with this linkage score. We test >1,000 putative enhancers by transgenesis assays in zebrafish to ascertain the identity of the target gene. The majority of active enhancers drive a transgenic expression in a pattern consistent with the known expression of a linked gene. These results show that evolutionary maintenance of linkage is a reliable predictor of an enhancer's function, and provide new information to discover the genetic basis of diseases caused by the mis-regulation of gene expression., Enhancers regulate the transcription of genes over long genomic distances. Here, the authors show that enhancer function is correlated with maintenance of linkage between non-coding elements and neighbouring genes in the human X chromosome and that enhancers in zebrafish drive expression in a pattern consistent with the expression of a linked gene.

Published
2015
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10. A SNP in the ABCC11 gene is the determinant of human earwax type

Author

Yoshiura, Koh-ichiro, primary, Kinoshita, Akira, additional, Ishida, Takafumi, additional, Ninokata, Aya, additional, Ishikawa, Toshihisa, additional, Kaname, Tadashi, additional, Bannai, Makoto, additional, Tokunaga, Katsushi, additional, Sonoda, Shunro, additional, Komaki, Ryoichi, additional, Ihara, Makoto, additional, Saenko, Vladimir A, additional, Alipov, Gabit K, additional, Sekine, Ichiro, additional, Komatsu, Kazuki, additional, Takahashi, Haruo, additional, Nakashima, Mitsuko, additional, Sosonkina, Nadiya, additional, Mapendano, Christophe K, additional, Ghadami, Mohsen, additional, Nomura, Masayo, additional, Liang, De-Sheng, additional, Miwa, Nobutomo, additional, Kim, Dae-Kwang, additional, Garidkhuu, Ariuntuul, additional, Natsume, Nagato, additional, Ohta, Tohru, additional, Tomita, Hiroaki, additional, Kaneko, Akira, additional, Kikuchi, Mihoko, additional, Russomando, Graciela, additional, Hirayama, Kenji, additional, Ishibashi, Minaka, additional, Takahashi, Aya, additional, Saitou, Naruya, additional, Murray, Jeffery C, additional, Saito, Susumu, additional, Nakamura, Yusuke, additional, and Niikawa, Norio, additional

Published
2006
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11. Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome.

Author

Naville M, Ishibashi M, Ferg M, Bengani H, Rinkwitz S, Krecsmarik M, Hawkins TA, Wilson SW, Manning E, Chilamakuri CS, Wilson DI, Louis A, Lucy Raymond F, Rastegar S, Strähle U, Lenhard B, Bally-Cuif L, van Heyningen V, FitzPatrick DR, Becker TS, and Roest Crollius H

Subjects
Animals, Animals, Genetically Modified, Evolution, Molecular, Gene Rearrangement genetics, Humans, Zebrafish, Chromosomes, Human, X genetics, Enhancer Elements, Genetic genetics, Gene Expression genetics, Genetic Linkage genetics, Selection, Genetic genetics
Abstract

Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage. Here we test this concept experimentally using the human X chromosome. We describe a scoring method to identify evolutionary maintenance of linkage between conserved noncoding elements and neighbouring genes. Chromatin marks associated with enhancer function are strongly correlated with this linkage score. We test >1,000 putative enhancers by transgenesis assays in zebrafish to ascertain the identity of the target gene. The majority of active enhancers drive a transgenic expression in a pattern consistent with the known expression of a linked gene. These results show that evolutionary maintenance of linkage is a reliable predictor of an enhancer's function, and provide new information to discover the genetic basis of diseases caused by the mis-regulation of gene expression.

Published
2015
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