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15 results on '"Isca, Chrystel"'

2. Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence

Author

Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Federica Bertolini, Michela Maur, Giorgia Guaitoli, Isca Chrystel, Uliano Morandi, Franco Stella, Massimo Dominici, and Khawaja Husnain Haider

Subjects
cancer, cancer stem cells, metastasis, microenvironment, stem cells, tumorigenesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Emerging evidence suggests that a small subpopulation of cancer stem cells (CSCs) is responsible for initiation, progression, and metastasis cascade in tumors. CSCs share characteristics with normal stem cells, i.e., self-renewal and differentiation potential, suggesting that they can drive cancer progression. Consequently, targeting CSCs to prevent tumor growth or regrowth might offer a chance to lead the fight against cancer. CSCs create their niche, a specific area within tissue with a unique microenvironment that sustains their vital functions. Interactions between CSCs and their niches play a critical role in regulating CSCs’ self-renewal and tumorigenesis. Differences observed in the frequency of CSCs, due to the phenotypic plasticity of many cancer cells, remain a challenge in cancer therapeutics, since CSCs can modulate their transcriptional activities into a more stem-like state to protect themselves from destruction. This plasticity represents an essential step for future therapeutic approaches. Regarding self-renewal, CSCs are modulated by the same molecular pathways found in normal stem cells, such as Wnt/β-catenin signaling, Notch signaling, and Hedgehog signaling. Another key characteristic of CSCs is their resistance to standard chemotherapy and radiotherapy treatments, due to their capacity to rest in a quiescent state. This review will analyze the primary mechanisms involved in CSC tumorigenesis, with particular attention to the roles of CSCs in tumor progression in benign and malignant diseases; and will examine future perspectives on the identification of new markers to better control tumorigenesis, as well as dissecting the metastasis process.

Published
2022
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4. Combined endocrine approaches vs endocrine therapy alone as first line treatment in elderly patients with hormone receptor-positive, HER2 negative, advanced breast cancer: to prescribe for the patient or the physician? A meta-analysis of phase II and III randomized clinical trials

Author

Omarini, Claudia, Piacentini, Federico, Sperduti, Isabella, Barbolini, Monica, Isca, Chrystel, Toss, Angela, Cortesi, Laura, Barbieri, Elena, Dominici, Massimo, and Moscetti, Luca

Published
2020
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5. Molecular Pathways of Breast Cancer in Systemic Sclerosis: Exploratory Immunohistochemical Analysis from the Sclero-Breast Study

Author

Isca, Chrystel, primary, Spinella, Amelia, additional, Toss, Angela, additional, de Pinto, Marco, additional, Ficarra, Guido, additional, Fabbiani, Luca, additional, Iannone, Anna, additional, Magnani, Luca, additional, Lumetti, Federica, additional, Macripò, Pierluca, additional, Vacchi, Caterina, additional, Gasparini, Elisa, additional, Piana, Simonetta, additional, Cortesi, Laura, additional, Maiorana, Antonino, additional, Salvarani, Carlo, additional, Dominici, Massimo, additional, and Giuggioli, Dilia, additional

Published
2022
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6. Thyroid function impairment after chemo-immunotherapy for advanced NSCLC: a single institutional retrospective report

Author

Trudu, Lucia, primary, Guaitoli, Giorgia, additional, Bertolini, Federica, additional, Maur, Michela, additional, Santini, Chiara, additional, Papapietro, Vito Roberto, additional, Talerico, Sabrina, additional, Natalizio, Salvatore, additional, Isca, Chrystel, additional, Dominici, Massimo, additional, and Barbieri, Fausto, additional

Published
2022
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7. Circulating and Intracellular miRNAs as Prognostic and Predictive Factors in HER2-Positive Early Breast Cancer Treated with Neoadjuvant Chemotherapy: A Review of the Literature

Author

Isca, Chrystel, primary, Piacentini, Federico, additional, Mastrolia, Ilenia, additional, Masciale, Valentina, additional, Caggia, Federica, additional, Toss, Angela, additional, Piombino, Claudia, additional, Moscetti, Luca, additional, Barbolini, Monica, additional, Maur, Michela, additional, Dominici, Massimo, additional, and Omarini, Claudia, additional

Published
2021
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8. Clinical and Pathological Features of Breast Cancer in Systemic Sclerosis: Results from the Sclero-Breast Study

Author

Toss, Angela, primary, Spinella, Amelia, additional, Isca, Chrystel, additional, Vacchi, Caterina, additional, Ficarra, Guido, additional, Fabbiani, Luca, additional, Iannone, Anna, additional, Magnani, Luca, additional, Castrignanò, Paola, additional, Macripò, Pierluca, additional, Gasparini, Elisa, additional, Piana, Simonetta, additional, Cortesi, Laura, additional, Maiorana, Antonino, additional, Salvarani, Carlo, additional, Dominici, Massimo, additional, and Giuggioli, Dilia, additional

Published
2021
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12. Predictive Role Of Body Composition Parameters In Operable Breast Cancer Patients Treated With Neoadjuvant Chemotherapy

Author

Omarini, Claudia, primary, Palumbo, Patrizia, additional, Pecchi, Annarita, additional, Draisci, Stefano, additional, Balduzzi, Sara, additional, Nasso, Cecilia, additional, Barbolini, Monica, additional, Isca, Chrystel, additional, Bocconi, Alessandro, additional, Moscetti, Luca, additional, Galetti, Silvia, additional, Tazzioli, Giovanni, additional, Torricelli, Pietro, additional, Cascinu, Stefano, additional, and Piacentini, Federico, additional

Published
2019
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13. Predictive Role Of Body Composition Parameters In Operable Breast Cancer Patients Treated With Neoadjuvant Chemotherapy

Author

Omarini,Claudia, Palumbo,Patrizia, Pecchi,Annarita, Draisci,Stefano, Balduzzi,Sara, Nasso,Cecilia, Barbolini,Monica, Isca,Chrystel, Bocconi,Alessandro, Moscetti,Luca, Galetti,Silvia, Tazzioli,Giovanni, Torricelli,Pietro, Cascinu,Stefano, Piacentini,Federico, Omarini, C., Palumbo, P., Pecchi, A., Draisci, S., Balduzzi, S., Nasso, C., Barbolini, M., Isca, C., Bocconi, A., Moscetti, L., Galetti, S., Tazzioli, G., Torricelli, P., Cascinu, S., and Piacentini, F.

Subjects
Sarcopenia, Pathological complete response, Fat tissue, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, sarcopenia, BMI, breast cancer, Breast cancer, Cancer Management and Research, pathological complete response, fat tissue, BMI, fat tissue, sarcopenia, pathological complete response, breast cancer, Original Research
Abstract

Claudia Omarini,1 Patrizia Palumbo,2 Annarita Pecchi,3 Stefano Draisci,3 Sara Balduzzi,4 Cecilia Nasso,1 Monica Barbolini,1 Chrystel Isca,1 Alessandro Bocconi,1 Luca Moscetti,1 Silvia Galetti,5 Giovanni Tazzioli,6 Pietro Torricelli,3 Stefano Cascinu,1 Federico Piacentini1 1Division of Medical Oncology, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy; 2Division of Clinical Nutrition and Metabolism, Department of Specialist Medicines, University Hospital of Modena, Modena, Italy; 3Department of Radiology, University Hospital of Modena, Modena, Italy; 4Statistics Unit, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy; 5Division of Clinical Nutrition and Metabolism, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy; 6Department of General Surgery and Surgical Specialities, University Hospital of Modena, Modena, ItalyCorrespondence: Claudia OmariniDivision of Medical Oncology, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Via Del Pozzo 71, Modena 41122, ItalyTel +39 059 4222845Email claudia.omarini@gmail.comBackground: Fat tissue is strongly involved in BC tumorigenesis inducing insulin resistance, chronic inflammation and hormonal changes. Computed tomography (CT) imaging instead of body mass index (BMI) gives a reliable measure of skeletal muscle mass and body fat distribution. The impact of body composition parameters (BCPs) on chemosensitivity is still debated. We examined the associations between BCPs and tumor response to neoadjuvant chemotherapy (NC) in patients treated for operable breast cancer (BC).Methods: A retrospective review of BC patients treated with NC in Modena Cancer Center between 2005 and 2017 was performed. BCPs, such as subcutaneous fat area (SFA), visceral fat area (VFA), lumbar skeletal muscle index (LSMI) and liver-to-spleen (L/S) ratio were calculated by Advance workstation (General Electric), software ADW server 3.2 or 4.7. BMI and BCPs were correlated with pathological complete response (pCR) and survival outcomes.Results: 407 patients were included in the study: 55% with BMI < 25 and 45% with BMI ≥ 25. 137 of them had pre-treatment CT scan imagines. Overweight was significantly associated with postmenopausal status and older age. Hormonal receptor positive BC was more frequent in overweight patients (p

Published
2019

15. Endocrine-based targeted combination versus endocrine therapy alone as first-line treatment in elderly patients with hormone receptor-positive advanced breast cancer: Meta-analysis of phase II and III randomized clinical trials.

Author

Omarini, Claudia, primary, Piacentini, Federico, additional, Sperduti, Isabella, additional, Barbolini, Monica, additional, Isca, Chrystel, additional, Nasso, Cecilia, additional, Toss, Angela, additional, D'Onofrio, Raffaella, additional, Cortesi, Laura, additional, Barbieri, Elena, additional, Cascinu, Stefano, additional, and Moscetti, Luca, additional

Published
2019
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