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1. A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study

Author

Ferial Fanian, Jean-Jacques Deutsch, Marie Thérèse Bousquet, Sylvie Boisnic, Pierre Andre, Isabelle Catoni, Ghislaine Beilin, Christian Lemmel, Maryna Taieb, Marie Gomel-Toledano, Hanane Issa, and Philippe Garcia

Subjects
skin rejuvenation, filler, non-crosslinked hyaluronic acid, biorevitalization, mesotherapy, neck rejuvenation, décolleté rejuvenation, Dermatology, RL1-803
Abstract

Background NCTF®135HA is a bio-revitalizing solution containing hyaluronic acid designed to compensate for skin dehydration, fatigue, and fine wrinkles associated with endogenous and environmental aging. Methods We conducted a randomized, active-controlled study to evaluate the efficacy and tolerability of NCTF®135HA injections on the face (crow’s feet), neck, and décolleté regions. Subjects were randomly assigned (3:1) to receive three NCTF®135HA treatment sessions plus twice-daily anti-aging moisturizer cream or cream alone (control). The primary outcome was the reduction in superficial wrinkles between baseline and Day (D)75 in the three areas, assessed by profilometric measures, clinical scoring, subjective changes, and tolerability. Results 146 subjects were randomized to NCTF®135HA (n = 107) or control (n = 38). At D75 and D120, NCTF®135HA significantly reduced wrinkles in all three areas and improved facial radiance scores compared with the control. Skin hydration significantly increased 7 d after the last NCTF®135HA injection. Self-esteem scales showed statistically significant improvements at D75 and D120 in subjects treated with NCTF®135HA versus baseline. Most adverse events were mild, resolved within 48 h, and were related to the injection procedure. Conclusion NCTF®135HA is an effective and well-tolerated treatment to reduce the skin signs of aging. The results are significantly superior to a routine anti-aging cream alone. (Funded by Laboratories FILLMED; ID-RCB number: 2018-A03167-48; clinicaltrials.gov number: NCT05609617)

Published
2023
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2. A prospective multicenter clinical trial evaluating the efficacy and safety of a hyaluronic acid-based filler with Tri-Hyal technology in the treatment of lips and the perioral area

Author

Agnès Ehlinger‐David, Mihai Gorj, Frédéric Braccini, Federico Loreto, Anne Grand‐Vincent, Philippe Garcia, Maryna Taieb, Laurent Benadiba, Isabelle Catoni, Elena Rumyantseva Mathey, Jean‐Jacques Deutsch, Philippe Bahadoran, Thibaud Vincent, Michel David, Hugues Cartier, Karim Nadra, Nicholas Moellhoff, and Ferial Fanian

Subjects
Dermatology
Abstract

Age-related changes of facial soft tissue cause clinical signs of facial aging such as lip atrophy, marionette lines, and an accentuated nasolabial fold. These changes can be modified using dermal fillers.To evaluate efficacy, longevity, and safety of a cross-linked hyaluronic acid-based filler with Tri-Hyal technology in the treatment of lips, nasolabial folds, and marionette lines.This prospective, multi-center trial evaluated injections of three different areas (lips, nasolabial fold alone, or with marionette wrinkles) with a soft tissue filler containing 25 mg/ml cross-linked hyaluronic acid and 0.3% lidocaine. Primary endpoint was the aesthetic correction 3 weeks after one injection session without touch-up. Follow-up was 18 months. Assessments were performed using the Global Aesthetic Score (GAS), clinical scoring based on photographic scales, high-frequency ultrasound imaging, and the Global Aesthetic Improvement Scale (GAIS).In total, 100 subjects were injected. GAS improved significantly for all treatment indications at 3 weeks (p 0.0001). Success rates were highest for nasolabial folds (98.4%), followed by marionette lines (94.4%) and lips (73.5%). After 18 months post-injection, success was observed in 91%, 88%, and 33% of subjects injected into nasolabial folds, marionette lines, and lips, respectively. GAIS scored highest for nasolabial folds (SGAIS: 71%; IGAIS: 40%), followed by marionette lines (SGAIS: 56%; IGAIS: 33%) and lips (SGAIS: 30%; IGAIS: 22%) at 18 months follow-up.The filler demonstrated high efficacy and safety in all indications. Regional differences in longevity were evident. Thus, the necessity of regional retreatments should be discussed with patients before injection.

Published
2022

3. Chirurgie plastique esthétique de la face et du cou - Volume 2

Author

Jean-Pierre Bessède, Eric Baggio, Philippe Boudard, Isabelle Catoni, Jean-Baptiste Charrier, Joseph Château, François Disant, Sarah Dufau-Perry, Joëlle Huth, Philippe Kestemont, Justin MICHEL, Thierry Malet, Francesco Perrone, Sylvie Poignonec, Roberto Polselli, Thomas Radulesco, Jean-Marc Ruban, Yves Saban, José Santini, Jean-Marc Thomassin, Florence Turner, Delphine Vertu-Ciolino, Cécile Winter, Jean-Jacques Pessey, Dominique Stoll, Seli ARSLAN, Jean-Pierre Bessède, Eric Baggio, Philippe Boudard, Isabelle Catoni, Jean-Baptiste Charrier, Joseph Château, François Disant, Sarah Dufau-Perry, Joëlle Huth, Philippe Kestemont, Justin MICHEL, Thierry Malet, Francesco Perrone, Sylvie Poignonec, Roberto Polselli, Thomas Radulesco, Jean-Marc Ruban, Yves Saban, José Santini, Jean-Marc Thomassin, Florence Turner, Delphine Vertu-Ciolino, Cécile Winter, Jean-Jacques Pessey, Dominique Stoll, and Seli ARSLAN

Subjects
Surgery, Plastic, Face--Surgery, Neck--Surgery
Abstract

Après la parution de Chirurgie plastique réparatrice de la face et du cou, ce second volume est consacré exclusivement à la chirurgie plastique esthétique. Il apporte un complément indispensable au praticien soucieux d'approfondir ses connaissances. Sont successivement abordés dans ce volume : – la prise en charge du rajeunissement facial et la chirurgie esthétique des paupières ; – les rhinoplasties esthétiques correctrices et fonctionnelles ; – la chirurgie orthognathique de l'adulte et l'esthétique faciale ; – les aspects médicolégaux en chirurgie plastique et esthétique de la face et du cou. Richement illustré, complété de vidéos opératoires en ligne et de nombreux cas cliniques, l'ouvrage, concis et didactique, offre une vision des connaissances pluridisciplinaires indispensables à une prise en charge et une thérapeutique de qualité. Les collaborateurs, praticiens et enseignants, apportent ici toute leur expérience. L'ouvrage s'adresse aux chirurgiens plasticiens, esthétiques, ORL et cervicofaciaux et à tous les spécialistes de chirurgie plastique et esthétique de la face et du cou. Pour accéder au complément en ligne de cet ouvrage, cliquez ici.

Published
2012

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