916 results on '"Isaacs R"'
Search Results
2. Bevacizumab as adjuvant treatment of colon cancer: updated results from the S-AVANT phase III study by the GERCOR Group
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André, T., Vernerey, D., Im, S.A., Bodoky, G., Buzzoni, R., Reingold, S., Rivera, F., McKendrick, J., Scheithauer, W., Ravit, G., Fountzilas, G., Yong, W.P., Isaacs, R., Österlund, P., Liang, J.T., Creemers, G.J., Rakez, M., Van Cutsem, E., Cunningham, D., Tabernero, J., and de Gramont, A.
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- 2020
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3. Narrow pollen diets are associated with declining Midwestern bumble bee species
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Wood, T. J., Gibbs, J., Graham, K. K., and Isaacs, R.
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- 2019
4. Design errors in vital sign charts used in consultant-led maternity units in the United Kingdom
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Isaacs, R., Smith, G., Gale-Andrews, L., Wee, M., van Teijlingen, E., Bick, D., and Hundley, V.
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- 2019
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5. Scaling analysis of the static and dynamic critical exponents in under, over, and optimally-doped Pr$_{2-x}$Ce$_x$CuO$_{4-y}$ films
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Sullivan, M. C., Isaacs, R. A., Salvaggio, M. F., Sousa, J., Stathis, C. G., and Olson, J. B.
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Condensed Matter - Superconductivity - Abstract
We report on current-voltage measurements of the zero-field normal-superconducting phase transition in thin films of Pr$_{2-x}$Ce$_x$CuO$_{4-y}$ as a function of doping. We find that the small size of the critical regime in these materials ($\approx 25$ mK) gives rise to mean-field behavior at the phase transition with a static exponent of $\nu \approx 0.5$ for all dopings (in contrast to hole-doped $\mathrm{YBa_{2}Cu_{3}O_{7-\delta}}$). We also find mean-field behavior in the dynamic exponent $z$. This indicates that Pr$_{2-x}$Ce$_x$CuO$_{4-y}$ behaves similarly to conventional superconductors in contrast to other cuprate superconductors. However, as the transition width in our samples decreases, the dynamic critical exponent approaches $z=1.5$, similar to the critical exponent found in hole-doped $\mathrm{YBa_{2}Cu_{3}O_{7-\delta}}$., Comment: 6 pages 4 figures
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- 2009
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6. From research to action: Enhancing crop yield through wild pollinators
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Garibaldi, LA, Carvalheiro, LG, Leonhardt, SD, Aizen, MA, Blaauw, BR, Isaacs, R, Kuhlmann, M, Kleijn, D, Klein, AM, Kremen, C, Morandin, L, Scheper, J, and Winfree, R
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Ecology - Abstract
Recent evidence highlights the value of wild-insect species richness and abundance for crop pollination worldwide. Yet, deliberate physical importation of single species (eg European honey bees) into crop fields for pollination remains the mainstream management approach, and implementation of practices to enhance crop yield (production per area) through wild insects is only just beginning. With few exceptions, studies measuring the impacts of pollinator-supporting practices on wild-insect richness and pollination service success - particularly in relation to long-term crop yield and economic profit - Are rare. Here, we provide a general framework and examples of approaches for enhancing pollinator richness and abundance, quantity and quality of pollen on stigmas, crop yield, and farmers' profit, including some benefits detected only through long-term monitoring. We argue for integrating the promotion of wild-insect species richness with single-species management to benefit farmers and society.
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- 2014
7. Limited phenological and dietary overlap between bee communities in spring flowering crops and herbaceous enhancements
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Wood, T. J., Gibbs, J., Rothwell, N., Wilson, J. K., Gut, L., Brokaw, J., and Isaacs, R.
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- 2018
8. Vital signs and other observations used to detect deterioration in pregnant women: an analysis of vital sign charts in consultant-led UK maternity units
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Smith, G.B., Isaacs, R., Andrews, L., Wee, M.Y.K., van Teijlingen, E., Bick, D.E., and Hundley, V.
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- 2017
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9. Size Structure of a Dominant Neotropical Forest Tree Species, Dicymbe altsonii, in Guyana and Some Factors Reducing Seedling Leaf Area
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Isaacs, R., Gillman, M. P., Johnston, M., Marsh, F., and Wood, B. C.
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- 1996
10. Vertical Position of Traps Influences Captures of Eastern Cherry Fruit Fly (Diptera: Tephritidae)
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Pelz-Stelinski, K. S., Gut, L. J., and Isaacs, R.
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- 2006
11. IPM case studies: berry crops.
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Isaacs, R., primary, Birch, A. N. E., additional, and Martin, R. T. R., additional
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- 2017
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12. CropPol: A dynamic, open and global database on crop pollination
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Allen-Perkins, A, Magrach, A, Dainese, M, Garibaldi, LA, Kleijn, D, Rader, R, Reilly, JR, Winfree, R, Lundin, O, McGrady, CM, Brittain, C, Biddinger, DJ, Artz, DR, Elle, E, Hoffman, G, Ellis, JD, Daniels, J, Gibbs, J, Campbell, JW, Brokaw, J, Wilson, JK, Mason, K, Ward, KL, Gundersen, KB, Bobiwash, K, Gut, L, Rowe, LM, Boyle, NK, Williams, NM, Joshi, NK, Rothwell, N, Gillespie, RL, Isaacs, R, Fleischer, SJ, Peterson, SS, Rao, S, Pitts-Singer, TL, Fijen, T, Boreux, V, Rundlof, M, Viana, BF, Klein, A-M, Smith, HG, Bommarco, R, Carvalheiro, LG, Ricketts, TH, Ghazoul, J, Krishnan, S, Benjamin, FE, Loureiro, J, Castro, S, Raine, NE, de Groot, GA, Horgan, FG, Hipolito, J, Smagghe, G, Meeus, I, Eeraerts, M, Potts, SG, Kremen, C, Garcia, D, Minarro, M, Crowder, DW, Pisanty, G, Mandelik, Y, Vereecken, NJ, Leclercq, N, Weekers, T, Lindstrom, SAM, Stanley, DA, Zaragoza-Trello, C, Nicholson, CC, Scheper, J, Rad, C, Marks, EAN, Mota, L, Danforth, B, Park, M, Bezerra, ADM, Freitas, BM, Mallinger, RE, Oliveira da Silva, F, Willcox, B, Ramos, DL, da Silva e Silva, FD, Lazaro, A, Alomar, D, Gonzalez-Estevez, MA, Taki, H, Cariveau, DP, Garratt, MPD, Nabaes Jodar, DN, Stewart, RIA, Ariza, D, Pisman, M, Lichtenberg, EM, Schueepp, C, Herzog, F, Entling, MH, Dupont, YL, Michener, CD, Daily, GC, Ehrlich, PR, Burns, KLW, Vila, M, Robson, A, Howlett, B, Blechschmidt, L, Jauker, F, Schwarzbach, F, Nesper, M, Diekoetter, T, Wolters, V, Castro, H, Gaspar, H, Nault, BA, Badenhausser, I, Petersen, JD, Tscharntke, T, Bretagnolle, V, Willis Chan, DS, Chacoff, N, Andersson, GKS, Jha, S, Colville, JF, Veldtman, R, Coutinho, J, Bianchi, FJJA, Sutter, L, Albrecht, M, Jeanneret, P, Zou, Y, Averill, AL, Saez, A, Sciligo, AR, Vergara, CH, Bloom, EH, Oeller, E, Badano, EI, Loeb, GM, Grab, H, Ekroos, J, Gagic, V, Cunningham, SA, Astrom, J, Cavigliasso, P, Trillo, A, Classen, A, Mauchline, AL, Montero-Castano, A, Wilby, A, Woodcock, BA, Sidhu, CS, Steffan-Dewenter, I, Vogiatzakis, IN, Herrera, JM, Otieno, M, Gikungu, MW, Cusser, SJ, Nauss, T, Nilsson, L, Knapp, J, Ortega-Marcos, JJ, Gonzalez, JA, Osborne, JL, Blanche, R, Shaw, RF, Hevia, V, Stout, J, Arthur, AD, Blochtein, B, Szentgyorgyi, H, Li, J, Mayfield, MM, Woyciechowski, M, Nunes-Silva, P, Halinski de Oliveira, R, Henry, S, Simmons, BI, Dalsgaard, B, Hansen, K, Sritongchuay, T, O'Reilly, AD, Chamorro Garcia, FJ, Nates Parra, G, Magalhaes Pigozo, C, Bartomeus, I, Allen-Perkins, A, Magrach, A, Dainese, M, Garibaldi, LA, Kleijn, D, Rader, R, Reilly, JR, Winfree, R, Lundin, O, McGrady, CM, Brittain, C, Biddinger, DJ, Artz, DR, Elle, E, Hoffman, G, Ellis, JD, Daniels, J, Gibbs, J, Campbell, JW, Brokaw, J, Wilson, JK, Mason, K, Ward, KL, Gundersen, KB, Bobiwash, K, Gut, L, Rowe, LM, Boyle, NK, Williams, NM, Joshi, NK, Rothwell, N, Gillespie, RL, Isaacs, R, Fleischer, SJ, Peterson, SS, Rao, S, Pitts-Singer, TL, Fijen, T, Boreux, V, Rundlof, M, Viana, BF, Klein, A-M, Smith, HG, Bommarco, R, Carvalheiro, LG, Ricketts, TH, Ghazoul, J, Krishnan, S, Benjamin, FE, Loureiro, J, Castro, S, Raine, NE, de Groot, GA, Horgan, FG, Hipolito, J, Smagghe, G, Meeus, I, Eeraerts, M, Potts, SG, Kremen, C, Garcia, D, Minarro, M, Crowder, DW, Pisanty, G, Mandelik, Y, Vereecken, NJ, Leclercq, N, Weekers, T, Lindstrom, SAM, Stanley, DA, Zaragoza-Trello, C, Nicholson, CC, Scheper, J, Rad, C, Marks, EAN, Mota, L, Danforth, B, Park, M, Bezerra, ADM, Freitas, BM, Mallinger, RE, Oliveira da Silva, F, Willcox, B, Ramos, DL, da Silva e Silva, FD, Lazaro, A, Alomar, D, Gonzalez-Estevez, MA, Taki, H, Cariveau, DP, Garratt, MPD, Nabaes Jodar, DN, Stewart, RIA, Ariza, D, Pisman, M, Lichtenberg, EM, Schueepp, C, Herzog, F, Entling, MH, Dupont, YL, Michener, CD, Daily, GC, Ehrlich, PR, Burns, KLW, Vila, M, Robson, A, Howlett, B, Blechschmidt, L, Jauker, F, Schwarzbach, F, Nesper, M, Diekoetter, T, Wolters, V, Castro, H, Gaspar, H, Nault, BA, Badenhausser, I, Petersen, JD, Tscharntke, T, Bretagnolle, V, Willis Chan, DS, Chacoff, N, Andersson, GKS, Jha, S, Colville, JF, Veldtman, R, Coutinho, J, Bianchi, FJJA, Sutter, L, Albrecht, M, Jeanneret, P, Zou, Y, Averill, AL, Saez, A, Sciligo, AR, Vergara, CH, Bloom, EH, Oeller, E, Badano, EI, Loeb, GM, Grab, H, Ekroos, J, Gagic, V, Cunningham, SA, Astrom, J, Cavigliasso, P, Trillo, A, Classen, A, Mauchline, AL, Montero-Castano, A, Wilby, A, Woodcock, BA, Sidhu, CS, Steffan-Dewenter, I, Vogiatzakis, IN, Herrera, JM, Otieno, M, Gikungu, MW, Cusser, SJ, Nauss, T, Nilsson, L, Knapp, J, Ortega-Marcos, JJ, Gonzalez, JA, Osborne, JL, Blanche, R, Shaw, RF, Hevia, V, Stout, J, Arthur, AD, Blochtein, B, Szentgyorgyi, H, Li, J, Mayfield, MM, Woyciechowski, M, Nunes-Silva, P, Halinski de Oliveira, R, Henry, S, Simmons, BI, Dalsgaard, B, Hansen, K, Sritongchuay, T, O'Reilly, AD, Chamorro Garcia, FJ, Nates Parra, G, Magalhaes Pigozo, C, and Bartomeus, I
- Abstract
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this service, develop predictions, and inform management actions. Here, we present CropPol, a dynamic, open, and global database on crop pollination. It contains measurements recorded from 202 crop studies, covering 3,394 field observations, 2,552 yield measurements (i.e., berry mass, number of fruits, and fruit density [kg/ha], among others), and 47,752 insect records from 48 commercial crops distributed around the globe. CropPol comprises 32 of the 87 leading global crops and commodities that are pollinator dependent. Malus domestica is the most represented crop (32 studies), followed by Brassica napus (22 studies), Vaccinium corymbosum (13 studies), and Citrullus lanatus (12 studies). The most abundant pollinator guilds recorded are honey bees (34.22% counts), bumblebees (19.19%), flies other than Syrphidae and Bombyliidae (13.18%), other wild bees (13.13%), beetles (10.97%), Syrphidae (4.87%), and Bombyliidae (0.05%). Locations comprise 34 countries distributed among Europe (76 studies), North America (60), Latin America and the Caribbean (29), Asia (20), Oceania (10), and Africa (7). Sampling spans three decades and is concentrated on 2001-2005 (21 studies), 2006-2010 (40), 2011-2015 (88), and 2016-2020 (50). This is the most comprehensive open global data set on measurements of crop flower visitors, crop pollinators and pollination to date, and we encourage researchers to add more datasets to this database in the future. This data set is released for non-commercial use only. Credits should be given to this paper (i.e., proper citation), and the products generated with this da
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- 2022
13. Verbesserung der Befestigung von Silikonschiffchenlinsen durch den Gebrauch von Positionierungslöchern in der Linsenhaptik
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Apple, D. J., Kent, D. G., Peng, Q., Isaacs, R., Auffarth, G. U., Vörösmarthy, Daniel, editor, Duncker, Gernot, editor, and Hartmann, Christian, editor
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- 1997
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14. Grape Berry Moth Control in Concord Grape, 2021
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Wheeler, C E, primary, Bosch, A K, additional, VanWoerkom, A H, additional, Wise, J C, additional, and Isaacs, R, additional
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- 2022
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15. Hematologic effects of recombinant human Interleukin-6 (rhIL-6) in sarcoma patients receiving maid chemotherapy: phase I trial
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Bukowski, R. M., Isaacs, R., Gordon, M., Demetri, G. D., Amuels, B., Young, D. C., Samuel, S., McLain, D., Levitt, D., Banzet, P., editor, Holland, J. F., editor, Khayat, D., editor, and Weil, M., editor
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- 1994
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16. Impact of Bacillus Calmette-Guerin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection
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Tabiri, Stephen, Kamarajah, Sivesh K, Nepogodiev, Dmitri, Li, Elizabeth, Simoes, Joana, Sravanam, Sanskrithi, Owusu, Sheila Agyeiwaa, Mahama, Haruna, Agyeman, Yaa Nyarko, Arthur, Joshua, Kunfah, Sheba Mary, Gyamfi, Frank Enoch, Owusu, Emmanuel Abem, Loffler, Markus W, Wandoh, Paul, Bhangu, Aneel, Siaw-Acheampong, Kwabena, Argus, Leah, Chaudhry, Daoud, Dawson, Brett E, Glasbey, James C, Gujjuri, Rohan R, Jones, Conor S, Khatri, Chetan, Keatley, James M, Lawday, Samuel, Mann, Harvinder, Marson, Ella J, Mclean, Kenneth A, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Dajti, Irida, Gjata, Arben, Boccalatte, Luis, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Townend, Philip, Aigner, Felix, Kronberger, Irmgard, Hossain, Kamral, VanRamshorst, Gabrielle, Lawani, Ismail, Ataide, Gustavo, Baiocchi, Glauco, Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Olivos, Maricarmen, Calvache, Jose, Perez Rivera, Carlos Jose, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Klat, Jaroslav, Novysedlak, Rene, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango, Eddy, Emile, Sameh H, Mengesha, Mengistu Gebreyohanes, Hailu, Dr Samuel, Tamiru, Hailu, Kauppila, Joonas, Arnaud, Alexis, Albertsmeiers, Markus, Lederhuber, Hans, Loffler, Markus, Metallidis, Symeon, Tsoulfas, Georgios, Lorena, Maria Aguilera, Grecinos, Gustavo, Mersich, Tamas, Wettstein, Daniel, Ghosh, Dhruv, Kembuan, Gabriele, Brouk, Peiman, Khosravi, Mohammad, Mozafari, Masoud, Adil, Ahmed, Mohan, Helen M, Zmora, Oded, Fiore, Marco, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Satoi, Sohei, Ayasra, Faris, Chaar, Mohammad, Fakhradiyev, Ildar R, Jamal, Mohammad, Elhadi, Muhammed, Gulla, Aiste, Roslani, April, Martinez, Laura, Ramos De la Medina, Antonio, Outani, Oumaima, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, van der Plas, Willemijn, Ademuyiwa, Adesoji, Osinaike, Babatunde, Seyi-olajide, Justina, Williams, Emmanuel, Pejkova, Sofija, Augestad, Knut Magne, Soreide, Kjetil, Al Balushi, Zainab, Qureshi, Ahmad, Sayyed, Raza, Daraghmeh, Mustafa Abu Mohsen, Abukhalaf, Sadi, Cukier, Moises, Gomez, Hugo, Shu, Sebastian, Vasquez, Ximena, Parreno-Sacdalan, Marie Dione, Major, Piotr, Azevedo, Jose, Cunha, Miguel, Santos, Irene, Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Litvin, Andrey, Ntirenganya, Faustin, AlAmeer, Ehab, Radenkovic, Dejan, Xiang, Frederick Koh Hong, Hoe, Chew Min, Yong, James Ngu Chi, Moore, Rachel, Nhlabathi, Ncamsile, Colino, Ruth Blanco, Bravo, Ana Minaya, Minaya-Bravo, Ana, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Elmujtaba, Mohammed, Jebril, William, Rutegard, Martin, Sund, Malin, Isik, Arda, Leventoglu, Sezai, Abbott, Tom EF, Benson, Ruth, Caruna, Ed, Chakrabortee, Sohini, Demetriades, Andreas, Desai, Anant, Drake, Thomas D, Edwards, John G, Evans, Jonathan P, Ford, Samuel, Fotopoulou, Christina, Griffiths, Ewen, Hutchinson, Peter, Jenkinson, Michael D, Khan, Tabassum, Knight, Stephen, Kolias, Angelos, Leung, Elaine, McKay, Siobhan, Norman, Lisa, Ots, Riinu, Raghavan, Vidya, Roberts, Keith, Schache, Andrew, Shaw, Richard, Shaw, Katie, Smart, Neil, Stewart, Grant, Sundar, Sudha, Vimalchandran, Dale, Wright, Naomi, Alshryda, Sattar, Alser, Osaid, Breen, Kerry, Ganly, Ian, Kaafarani, Haytham, Kendall, Brittany, Mashbari, Hassan, Al Naggar, Hamza, Mazingi, Dennis, Dajti, I, Valenzuela, JI, Boccalatte, LA, Gemelli, NA, Smith, DE, Dudi-Venkata, NN, Kroon, HM, Sammour, T, Roberts, M, Mitchell, D, Lah, K, Pearce, A, Morton, A, Dawson, AC, Drane, A, Sharpin, C, Nataraja, RM, Pacilli, M, Cox, DRA, Muralidharan, V, Riddiough, GE, Clarke, EM, Jamel, W, Qin, KR, Pockney, P, Cope, D, Egoroff, N, Lott, N, Putnis, S, De Robles, S, Ang, Z, Mitteregger, M, Uranitsch, S, Stiegler, M, Seitinger, G, Aigner, F, Lumenta, DB, Nischwitz, SP, Richtig, E, Pau, M, Srekl-Filzmaier, P, Eibinger, N, Michelitsch, B, Fediuk, M, Papinutti, A, Seidel, G, Kahn, J, Cohnert, TU, Messner, F, Ofner, D, Presl, J, Varga, M, Weitzendorfer, M, Emmanuel, K, Binder, AD, Zimmermann, M, Holawe, S, Nkenke, E, Grimm, C, Kranawetter, M, Mitul, Rahman A, Islam, N, Karim, S, Komen, N, Ang, E, De Praetere, H, Tollens, T, Schols, G, Smets, C, Haenen, L, Quintens, J, Van Belle, K, Van Ramshorst, GH, Pattyn, P, Desender, L, Martens, T, Van de Putte, D, Lerut, P, Grimonprez, A, Janssen, M, De Smul, G, Wallaert, P, Van den Eynde, J, Oosterlinck, W, Van den Eynde, R, Sermon, A, Boeckxstaens, A, Cordonnier, A, De Coster, J, Jaekers, J, Politis, C, Miserez, M, Duchateau, N, De Gheldere, C, Flamey, N, Christiano, A, Guidi, B, Minussi, AL, Castro, S, Okoba, W, Maldonado, FHR, Oliveira, P, Baldasso, T, Santos, L, Gomes, GMA, Buarque, IL, Pol-Fachin, L, Bezerra, TS, Barros, AV, Leite, ALS, Silvestre, DWA, Ferro, CC, Araujo, MS, Lopes, LM, Damasceno, PD, Araujo, DHS, Laporte, G, Salem, MC, Guimaraes-Filho, MAC, Nacif, L, Flumignan, RLG, Nakano, LCU, Kuramoto, DAB, Aidar, ALS, Pereda, MR, Correia, RM, Santos, BC, Carvalho, AA, Amorim, JE, Guedes Neto, HJ, Areias, LL, Sousa, AF, Flumignan, CDQ, Lustre, WG, Moreno, DH, Barros-Jr, N, Baptista-Silva, JCC, Matos, LL, Kowaski, LP, Kulcsar, MAV, Nunes, KS, Teixeira, MF, Nunes, RL, Ijichi, TR, Kim, NJ, Marreiro, A, Muller, B, Awada, Barakat J, Baiocchi, G, Kowalski, LP, Vartanian, JG, Makdissi, FB, Aguiar, Jr S Jr, Marques, N, Carvalho, GB, Marques, TMDM, Abdallah, EA, Zurstrassen, CE, Gross, JL, Zequi, SC, Goncalves, BT, Santos, SS, Duprat, JP, Coimbra, FJF, Cicco, R, Takeda, F, Cecconello, I, Jr, Ribeiro Junior U, Gatti, A, Oliva, R, Nardi, C, Slavchev, M, Atanasov, B, Belev, N, Dell, A, Bigam, D, Dajani, K, Al Riyami, S, Martin, J, Cheng, D, Yang, H, Fayad, A, Carrier, FM, Amzallag, E, Desroches, J, Ruel, M, Caminsky, NG, Boutros, M, Moon, J, Wong, EG, Vanounou, T, Pelletier, J, Wong, S, Girsowicz, E, Bayne, J, Obrand, D, Gill, H, Steinmetz, O, MacKenzie, K, Lukaszewski, M, Jamjoum, G, Richebe, P, Verdonck, O, Discepola, S, Godin, N, Idrissi, M, Briatico, D, Sharma, S, Talwar, G, Bailey, K, Lecluyse, V, Cote, G, Demyttenaere, S, Garfinkle, R, Kouyoumdjian, A, Dumitra, S, Khwaja, K, Luo, L, Berry, G, Liberman, AS, Schmid, S, Spicer, J, Al Farsi, M, Abou-Khalil, J, Couture, E, Mohammadi, S, Tremblay, H, Gagne, N, Bergeron, A, Turgeon, AF, Costerousse, O, Bellemare, D, Babin, C, Blier, C, Wood, ML, Persad, A, Groot, G, D'Aragon, F, Carbonneau, E, Bouchard, M, Masse, M, Pesant, F, Heroux, J, Karanicolas, P, Hallet, J, Nadler, A, Nathens, A, Ko, M, Brar, A, Mayson, K, Kidane, B, Srinathan, S, Escudero, MI, Reyes, JT, Modolo, MM, Ramirez Nieto, P, Sepulveda, R, Bolbaran, A, Molero, A, Ruiz, I, Reyes, GP, Salas, R, Suazo, C, Munoz, R, Grasset, E, Inzunza, M, Besser, N, Irarrazaval, MJ, Jarry, C, Bellolio, F, Manqui, Romero CA, Esquide, Ruiz M, Fuentes, T, Campos, J, Perez Rivera, CJ, Cabrera, PA, Pinilla, RE, Guevara, O, Jimenez Ramirez, LJ, Velasquez Cuasquen, BG, Mora, Herrera DR, Bonilla, A, Diaz, S, Manrique, E, Facundo, H, Bernal, Velez JL, Garcia, M, Guzman, L, Lehmann, C, Cervera, S, Sanchez, Trujillo LM, Guevara, R, Valbuena, D, Suarez, L, Jimenez, G, Velandia, A, Vargas, J, Espinosa, J, Rey, S, Jairo, Mendoza Quevedo, Calvache, JA, Orozco-Chamorro, CM, Sanchez-Gomez, TA, Rojas-Tejada, DA, Mihanovic, J, Bakmaz, B, Rakvin, I, Sulen, N, Andabaka, T, Luksic, I, Mamic, M, Martinek, L, Skrovina, M, Peteja, M, Kristensen, H, Mekhael, M, Christensen, P, Westh, L, Smith, H, Haugstvedt, AF, Jonsson, ML, Crespo, A, Batista, S, Rodriguez-Abreu, J, Tactuk, N, Diaz-Delgado, PJ, Rivas, R, Sarmiento-Bobadilla, JA, Ashoush, F, Abdelaal, Samir A, Qatora, MS, Hewalla, Elsayed ME, Metwalli, M, Atta, R, Abdelmajeed, A, Abosamak, NE, Sabry, A, Shehata, S, Sallam, I, Amira, G, Sherief, M, Sherif, A, Salem, H, Hamdy, R, Aboulkassem, H, Ghaly, G, Sherif, G, Morsi, A, Abdelrahman, A, Ahmed, 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Imam, SMB, Kalavrezos, N, Sinha, D, Green, Chand ML, Beech, N, McEwen, R, Kiconco, H, Andreani, SM, Bath, MF, Sahni, A, Judkins, N, Springford, Rigueros L, Bacarese-Hamilton, J, Taylor, FG, Parmar, C, Mccluney, S, Shah, S, Talwar, R, Patel, K, Askari, A, Jambulingam, PS, Shaw, S, Maity, A, Hatzantonis, C, Sagar, J, Kudchadkar, S, Cirocchi, N, Chan, CH, Reynolds, J, Alexander, ME, Smart, CJ, Jayasankar, B, Balasubramaniam, D, Abdelsaid, K, Mundkur, N, Gallagher, B, Shah, J, Anthoney, J, Emmerson, O, Stylianides, N, Abdalla, M, Newton, K, Bhatia, K, Edmondson, R, Abdeh, L, Jones, D, Zeiton, M, Ismail, O, Naseem, H, Advani, R, Duff, S, Moura, F, Brown, BC, Khan, A, Asaad, P, Wadham, B, Aneke, IA, Collis, J, Warburton, H, Fell, A, Smith, A, Halkias, C, Nikolaou, S, English, C, Kristinsson, S, Oni, T, Ilahi, N, Ballantyne, K, Woodward, Z, Merh, R, Dunning, J, Viswanath, Y, Freystaetter, K, Dixon, J, Hadfield, JN, Hilley, A, Egglestone, A, Smith, B, Hine, T, Keeler, B, Soulsby, RE, Taylor, A, Davies, E, Ryska, O, Raymond, T, Rogers, S, Tong, A, Hawkin, P, Tingle, S, Abbadessa, F, Sachdeva, A, Rai, B, Chan, CD, McPherson, I, Booth, K, Ali, Mahmoud F, Pandanaboyana, S, Grainger, T, Nandhra, S, Patience, A, Roy, C, Williams, T, Dawe, N, McCaffer, C, Riches, J, Bhattacharya, S, Moir, J, Kalson, NS, Ahmed, Elamin H, Mellor, C, Saleh, C, Koshy, RM, Hammond, J, Sanderson, L, Wahed, S, Phillips, AW, Ghosh, K, Tang, A, Beamish, AJ, Price, C, Bosanquet, D, Magowan, D, Solari, F, Williams, G, Nassa, H, Smith, L, Robertson-Smith, B, Mahmoud, A, Ameerally, P, Finch, JG, Gnanachandran, C, Pop, I, Rogers, M, Yousef, Y, Mohamed, I, Woods, R, Zahid, H, Mundy, G, Sreedharan, L, Baskaran, D, Shaikh, I, Seebah, K, Reid, J, Watts, D, Kouritas, V, Chrastek, D, Maryan, G, Gill, DF, Khatun, F, Gajjar, K, Williamson, K, Bratt, D, Konstantinidi, K, Walton, T, Burnside, N, Weaver, H, Hawari, M, Addae-Boateng, E, Rollett, RA, Collins, ML, Tamimy, MS, Riyat, H, Wen, J, Neil-Dwyer, J, Brewer, H, Humes, D, Worku, D, Chowdhury, A, Oyende, O, Lewis-Lloyd, C, Adiamah, A, Koh, A, Jackman, J, Vohra, R, Navarro, A, Reilly, J, Aujayeb, A, Townshend, D, McLarty, N, Shenfine, A, Jackson, K, Johnson, C, Dass, D, Ford, D, Winter, SC, Belcher, E, Stavroulias, D, Di Chiara, F, Wallwork, K, Qureishi, A, Lami, M, Sravanam, S, Mastoridis, S, Shah, K, Chidambaram, S, Smillie, R, Shaw, AV, Bandyopadhyay, S, Cernei, C, Bretherton, C, Jeyaretna, D, Ganau, M, Piper, RJ, Duck, E, Brown, S, Jelley, C, Tucker, SC, Bond-Smith, G, Griffin, XL, Tebala, GD, Neal, N, Vatish, M, Noton, TM, Ghattaura, H, Maher, M, Fu, H, Risk, OBF, Majd, Soleymani H, Sinha, S, Shankar, S, Aggarwal, A, Khatkar, H, Lakhoo, K, Verberne, C, Dean, B, Luney, C, Myatt, R, Williams, MA, McVeigh, J, Rogers, LJ, Labib, PL, Miller, D, Minto, G, Hope, N, Marchbank, A, Emslie, K, Panahi, P, Ho, B, Perkins, C, Clough, E, Roy, H, Enemosah, I, Campbell, R, Natale, J, Gohil, K, Rela, M, Raza, N, Biliatis, I, Khan, J, Thiruchandran, G, Toh, SKC, Ahmad, Y, Allana, A, Bellis, C, Babawale, O, Phan, YC, Lokman, U, Ismail, M, Koc, T, Witek, A, Duggleby, L, Shamoon, S, Stefan, S, Clancy, H, Chadha, R, Middleton, SB, Wilmott, K, Hayden, C, Mclaren, C, Sutton, J, Whyte, A, Belgaumkar, A, Day, A, Gilbert, C, Oyewole, B, Narayan, P, Dent, H, Sandhya, A, De Silva, T, Waheed, S, Kapoor, K, Belgaumkar, AP, Fahim, M, Gala, T, Mithany, R, Morgan, R, Abdelkarim, M, Maw, A, Asqalan, A, Venkatesan, Sundaram G, Singh, S, Mukherjee, S, Ferguson, D, Mansuri, A, Thakrar, A, Wickramarachchi, L, Cuthbert, R, Sivayoganathan, S, Chui, K, Karam, E, Dott, C, Madhvani, K, Hampton, M, Hormis, AP, Fountain, DM, Laurente, R, Sigamoney, KV, Dasa, M, George, K, Naqui, Z, Galhoum, M, Lipede, C, Gabr, A, Radhakrishnan, A, Hasan, MT, Kalenderov, R, Pathmanaban, O, Chelva, R, Branagan, G, Longstaff, L, Ding, D, Barlow, C, Foster, J, Edwards, J, Ward, A, Tadross, D, Majkowski, L, Blundell, C, Forlani, S, Nair, R, Guha, S, Brown, SR, Steele, C, Kelty, CJ, Newman, T, Lee, M, Chetty, G, Lye, G, Balasubramanian, SP, Shah, Sureshkumar N, Sherif, M, Al-mukhtar, A, Whitehall, E, Giblin, A, Sharkey, A, Adamec, A, Madan, S, Narice, B, Sterrenburg, M, Thompson, A, Varley, I, Stavrakas, M, Rominiyi, O, Ray, J, Crank, M, Bacon, A, Al-Tamimi, Y, Catto, J, Saad, S, Abd Kahar, NN, Sou, A, Simpson, D, Hamilton, E, Blair, J, Jallad, S, Lord, J, Anderson, C, El Kafsi, J, Logishetty, K, Saadya, A, Midha, R, Ip, M, Ponniah, Subbiah H, Stockdale, T, Bacarese-Hamilton, T, Foster, L, James, A, Anjarwalla, N, Henriques, Marujo D, Hettige, R, Baban, C, Tenovici, A, Salerno, G, Lane, J, Colvin, HV, Badran, A, Cadersa, A, Cumpstey, A, Hamady, Z, Aftab, R, Wensley, F, Byrne, J, Morrison-Jones, V, Sekhon, GK, Shields, H, Shakoor, Z, Yener, A, Talbot, T, Alzetani, A, Cresner, R, Babu, BHB, Liyanage, ASD, Newman, S, Blake, I, Weerasinghe, C, Baumber, R, Parry, J, Menakaya, C, Webb, JI, Antar, M, Modi, N, Sofat, R, Noel, J, Nunn, R, Adegbola, S, Eriberto, F, Sharma, V, Tanna, R, Lodhia, S, Johnson, D, Hughes, I, Hall, J, Rooney, J, Chatterji, S, Zhang, Y, Owen, R, Rudic, M, Hunt, J, Zakai, D, Aladeojebi, A, Ali, M, Gaunt, A, Barmayehvar, B, Kitchen, M, Gowda, M, Mansour, F, Jarvis, M, Halliday, E, Lefroy, R, Nanjaiah, P, Lin, DJ, Rajgor, AD, Scurrah, RJ, Kang, C, Watson, LJ, Harris, G, Royle, T, Cunningham, Y, Steel, B, Luk, ACO, Boulton, AJ, Khan, T, Bakolas, G, Herrod, P, Gemmill, E, Boyd-Carson, H, Jibreel, M, Lenzi, E, Saafan, T, Sapre, D, Li, Z, Parkins, K, Spencer, N, Harries, R, Egan, RJ, Motter, D, Jenvey, C, Mahoney, R, Fine, N, Minto, T, Henry, A, Hollyman, M, Grieco, C, Gemmell, C, Whitmore, H, Babar, MS, Goodrum, S, Scott, R, Collard, B, Lau, K, Thomas, E, Patel, A, Allison, J, Bowen, J, Dias, A, Mahendran, B, Gopalswamy, S, Patil, S, Scott, L, Sarveswaran, J, Michel, M, Ravindran, S, Subba, K, Abou-Foul, AK, Khalefa, M, Hossain, F, Moores, T, Pickering, L, Stables, G, Doorgakant, A, Thiruvasagam, VG, Carter, J, Reid, S, Mohammed, R, Marlow, W, Ferguson, H, Wilkin, R, Konstantinou, C, Yershov, D, Vatish, J, Denning, A, Shah, HB, Cross, GWV, Seyed-Safi, P, Smart, YW, Kuc, A, Al-Yaseen, M, Olivier, J, Hanna, M, Eskander, P, Duncan, R, Halaseh, S, Das, R, Jones, Wynn H, Divecha, H, Whelton, C, Board, T, Powell, S, Magee, C, Agarwal, K, Mangos, E, Nambirajan, T, Vidya, R, Chauhan, G, Kaur, J, Burahee, A, Bleibleh, S, Pigadas, N, Snee, D, Bhasin, S, Crichton, A, Habeebullah, A, Bodla, AS, Yassin, N, Mondragon, M, Dewan, V, Flindall, I, Mahendran, V, Hanson, A, Jenner, E, Richards, J, Thomas-Fernandez, K, Wall, R, Alqallaf, A, Ben-Sassi, A, Mellor, K, Joshi, P, Joshi, Y, Young, R, Miu, V, Sheridan, K, MacDonald, L, Green, S, Onos, L, Wong, JJ, Napolitano, L, Hemmila, M, Amin, D, Abramowicz, S, Roser, SM, Olson, KA, Riley, C, Heron, C, Cardenas, T, Leede, E, Thornhill, M, Haynes, AB, McElhinney, K, Roward, S, Trust, MD, Hill, CE, Teixeira, PG, Etchill, E, Stevens, K, Ladd, MR, Long, C, Rose, J, Kent, A, Yesantharao, P, Vervoort, D, Jenny, H, Gabre-Kidan, A, Margalit, A, Tsai, L, Malapati, H, Yesantharao, L, Abdou, H, Diaz, J, Richmond, M, Clark, J, OMeara, L, Hanna, N, Ying, Y, Fleming, J, Ovaitt, A, Gigliotti, J, Fuson, A, Cooper, Z, Salim, A, Hirji, SA, Chung, C, Hansen, L, Okafor, BU, Roxo, V, Raut, CP, Jolissaint, JS, Mahvi, DA, Kaafarani, H, Breen, K, Bankhead-Kendall, B, Alser, O, Mashbari, H, Velmahos, G, Maurer, LR, El Moheb, M, Gaitanidis, A, Naar, L, Christensen, MA, Kapoen, C, Langeveld, K, El Hechi, M, Mokhtari, A, Haqqani, MH, Drake, FT, Goldenberg-Sandau, A, Galbreath, B, Reinke, C, Ross, S, Thompson, K, Manning, D, Perkins, R, Evans, H, Masrur, M, Giulianotti, P, Benedetti, E, Chang, G, Ourieff, J, Dehart, D, Dorafshar, A, Price, T, Bhama, AR, Torquati, A, Cherullo, E, Kennedy, R, Myers, J, Rubin, K, Ban, VS, Aoun, SG, Batjer, HH, Caruso, J, Carmichael, H, Velopulos, CG, Wright, FL, Urban, S, McIntyre, Jr RC Jr, Schroeppel, TJ, Hennessy, EA, Dunn, J, Zier, L, Burlew, C, Coleman, J, Colling, KP, Hall, B, Rice, HE, Hwang, ES, Olson, SA, Moris, D, Verma, R, Hassan, R, Volpe, A, Merola, S, OBanion, LA, Lilienstein, J, Dirks, R, Marwan, H, Almasri, M, Kulkarni, G, Mehdi, M, Abouassi, A, Abdallah, M, San Andres, M, Eid, J, Aigbivbalu, E, Sundaresan, J, George, B, Ssentongo, A, Ssentongo, P, Oh, JS, Hazelton, J, Maines, J, Gusani, N, Garner, M, Horvath, S, Zheng, F, Ujiki, M, Kinnaman, G, Meagher, A, Sharma, I, Holler, E, McKenzie, K, Chan, J, Fretwell, K, III, Nugent Iii W, Khalil, A, Chen, D, Post, N, Rostkowski, T, Brahmbhatt, D, Huynh, K, Hibbard, ML, Schellenberg, M, Martin, RCG, Bhutiani, N, Giorgakis, E, Laryea, J, Bhavaraju, A, Sexton, K, Kost, M, Kimbrough, M, Burdine, L, Kalkwarf, K, Robertson, R, Gosain, A, Camp, L, Lewit, R, Kronenfeld, JP, Urrechaga, E, Goel, N, Rattan, R, Hart, V, Gilna, G, Cioci, A, Ruiz, G, Rakoczy, K, Pavlis, W, Saberi, R, Morris, R, Karam, BS, Brathwaite, CEM, Liu, H, Petrone, P, Hakmi, H, Sohail, AH, Baltazar, G, Heckburn, R, Nygaard, RM, Colonna, ET, Endorf, FW, Hill, MJ, Maiga, A, Dennis, B, Levin, JH, Lallemand, M, Choron, R, Peck, G, Soliman, F, Rehman, S, Glass, N, Juthani, B, Deisher, D, Ruzgar, NM, Ullrich, SJ, Sion, M, Paranjape, C, Kar, AR, Gillezeau, C, Rapp, J, Taioli, E, Miles, BA, Alpert, N, Podolsky, D, Coleman, NL, Callahan, MP, Ganly, I, Brown, L, Monson, JRT, Dehal, A, Abbas, A, Soliman, A, Kim, B, Jones, C, Dauer, Md, E, Renza-Stingone, E, Hernandez, E, Gokcen, E, Kropf, E, Sufrin, H, Hirsch, H, Ross, H, Engel, J, Sewards, J, Poggio, J, Sanserino, K, Rae, L, Philp, M, Metro, M, McNelis, P, Petrov, R, Pazionis, T, Till, B, Lamm, R, Rios-Diaz, AJ, Palazzo, F, Rosengart, M, Nicholson, K, Carrick, MM, Rodkey, K, Suri, A, Callcut, R, Nicholson, S, Talathoti, N, Klaristenfeld, D, Biffl, W, Marsh, C, Schaffer, K, Berndtson, AE, Averbach, S, Curry, T, Kwan-Feinberg, R, Consorti, E, Gonzalez, R, Grolman, R, Liu, T, Merzlikin, O, Abel, MK, Ozgediz, D, Boeck, M, Kornblith, LZ, Nunez-Garcia, B, Robinson, B, Park, P, Utria, AF, Rice-Townsend, SE, Javid, P, Hauptman, J, Kieran, K, Nehra, D, Walters, A, Cuschieri, J, Davidson, GH, Cosker, R, Eckhouse, S, Choudhry, A, Marx, W, Jamil, T, Seegert, S, Al-Embideen, S, Quintana, M, Jackson, H, Wexner, SD, Kent, I, Martins, PN, Alshehari, M, Al-Naggar, H, Alsayadi, M, Alyazidi, M, Shream, S, Alhaddad, W, Maqus, A, Abu Hamraa, M, Alsayadi, R, Ghannam, R, Al-Maqtari, S, Masdoos, S, Al-Harazi, Y, Bajjah, H, Al-ameri, S, Aldawbali, M, Gwini, GP, Mazingi, D, da Silva, AMR, DAragon, F, D'Agruma, M, D'Andrea, G, Angel, J, Zatecky, J, von Ahnen, T, ter Brugge, FM, Henegouwen, van Berge MI, van der Oest, MJW, van Petersen, AS, van der Meij, W, den Boer, FC, de Lacy, FB, Alga, A, von Fluee, M, ESCP, European Soc Coloproctology, SICCR, Italian Soc Colorectal Surg, ASiT, Assoc Surg Training, ISRC, Irish Surg Res Collaborative, Collaborative, COVIDSurg, European Soc Coloproctology ESCP, Italian Soc Colorectal Surg SICCR, Assoc Surg Training ASiT, Irish Surg Res Collaborative ISRC, COVIDSurg Collaborative, Meister, P. (Beitragende*r), Gallinat, Anja (Beitragende*r), Paul, Andreas (Beitragende*r), Collaborative, COVID Surg, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), COVID Surg Collaborative, Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
- Subjects
Science & Technology ,AcademicSubjects/MED00910 ,SARS-CoV-2 ,SARS-CoV-2 infection ,fungi ,Medizin ,Bjs/2 ,COVID-19 ,General Medicine ,vaccination ,mortality ,Bacillus Calmette-Guérin ,body regions ,COVID Surg Collaborative ,Research Letter ,BCG Vaccine ,Surgery ,Human medicine ,skin and connective tissue diseases ,AcademicSubjects/MED00010 ,humans ,Life Sciences & Biomedicine ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
There is little evidence around the potentially protective role of previous Bacillus Calmette-Guerin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 vaccination. Prior BCG vaccination did not protect SARS-CoV-2 infected patients against postoperative pulmonary complications and 30-day mortality. ispartof: BJS OPEN vol:5 issue:6 ispartof: location:England status: published
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- 2021
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17. Morphology and Distribution of Sensilla on the Antennae of Hylamorpha elegans Burmeister (Coleoptera: Scarabaeidae)
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Mutis, A, Palma, R, Parra, L, Alvear, M, Isaacs, R, Morón, M, and Quiroz, A
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- 2014
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18. A national survey of obstetric early warning systems in the United Kingdom: five years on
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Isaacs, R. A., Wee, M. Y. K., Bick, D. E., Beake, S., Sheppard, Z. A., Thomas, S., Hundley, V., Smith, G. B., van Teijlingen, E., and Thomas, P. W.
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- 2014
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19. Exploring host-associated differentiation in the North American native cranberry fruitworm, Acrobasis vaccinii, from blueberries and cranberries
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Medina, R. F., Szendrei, Z., Harrison, K., Isaacs, R., Averill, A., Malo, E. A., and Rodriguez-Saona, C.
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- 2014
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20. POS-560 HEMODIALYSIS CATHETER ASSOCIATED BLOODSTREAM INFECTIONS (CABSI) AT A TERTIARY CARE HOSPITAL IN NORTH INDIA: INCIDENCE,OUTCOME AND ANTIBIOGRAM OF THE ISOLATED ORGANISMS
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Bahl, A., primary, Rajamanickam, T., additional, Isaacs, R., additional, and Oberoi, A., additional
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- 2021
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21. Pimasertib Versus Dacarbazine in Patients With UnresectableNRAS-Mutated Cutaneous Melanoma: Phase II, Randomized, Controlled Trial with Crossover
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Lebbe, C, Dutriaux, C., Lesimple, T., Kruit, W, Kerger, J., Thomas, L, Guillot, B., Braud, F. (Filippo) de, Garbe, C. (Claus), Grob, J.J., Loquai, C., Ferraresi, V., Robert, C. (Caroline), Vasey, P., Conry, R. (Robert), Isaacs, R, Espinosa, L. (Lluis), Schüler, A. (Anne), Massimini, G., Dreno, B. (Brigitte), Lebbe, C, Dutriaux, C., Lesimple, T., Kruit, W, Kerger, J., Thomas, L, Guillot, B., Braud, F. (Filippo) de, Garbe, C. (Claus), Grob, J.J., Loquai, C., Ferraresi, V., Robert, C. (Caroline), Vasey, P., Conry, R. (Robert), Isaacs, R, Espinosa, L. (Lluis), Schüler, A. (Anne), Massimini, G., and Dreno, B. (Brigitte)
- Abstract
This study investigated the efficacy and safety of pimasertib (MEK1/MEK2 inhibitor) versus dacarbazine (DTIC) in patients with untreated NRAS-mutated melanoma. Phase II, multicenter, open-label trial. Patients with unresectable, stage IIIc/IVM1 NRAS-mutated cutaneous melanoma were randomized 2:1 to pimasertib (60 mg; oral twice-daily) or DTIC (1000 mg/m2 ; intravenously) on Day 1 of each 21-day cycle. Patients progressing on DTIC could crossover to pimasertib. Primary endpoint: investigator-assessed progression-free survival (PFS); secondary endpoints: overall survival (OS), objective response rate (ORR), quality of life (QoL), and safety. Overall, 194 patients were randomized (pimasertib n = 130, DTIC n = 64), and 191 received treatment (pimasertib n = 130, DTIC n = 61). PFS was significantly improved with pimasertib versus DTIC (median 13 versus 7 weeks, respectively; hazard ratio (HR) 0.59, 95% confidence interval (CI) 0.42–0.83; p = 0.0022). ORR was improved with pimasertib (odds ratio 2.24, 95% CI 1.00–4.98; p = 0.0453). OS was similar between treatments (median 9 versus 11 months, respectively; HR 0.89, 95% CI 0.61–1.30); 64% of patients receiving DTIC crossed over to pimasertib. Serious adverse events (AEs) were more frequent for pimasertib (57%) than DTIC (20%). The most common treatment-emergent AEs were diarrhea (82%) and blood creatine phosphokinase (CPK) increase (68%) for pimasertib, and nausea (41%) and fatigue (38%) for DTIC. Most frequent grade ≥3 AEs were CPK increase (34%) for pimasertib and neutropenia (15%) for DTIC. Mean QoL scores (baseline and last assessment) were similar between treatments. Pimasertib has activity in NRAS-mutated cutaneous melanoma and a safety profile consistent with known toxicities of MEK inhibitors. Trial registration: ClinicalTrials.gov, NCT01693068.
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- 2020
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22. Pimasertib Versus Dacarbazine in Patients With Unresectable NRAS-Mutated Cutaneous Melanoma: Phase II, Randomized, Controlled Trial with Crossover
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Lebbe, C, Dutriaux, C, Lesimple, T, Kruit, Wim, Kerger, J, Thomas, L, Guillot, B, de Braud, F, Garbe, C, Grob, JJ, Loquai, C, Ferraresi, V, Robert, C, Vasey, P, Conry, R, Isaacs, R, Espinosa, E, Schueler, A, Massimini, G, Dreno, B, Lebbe, C, Dutriaux, C, Lesimple, T, Kruit, Wim, Kerger, J, Thomas, L, Guillot, B, de Braud, F, Garbe, C, Grob, JJ, Loquai, C, Ferraresi, V, Robert, C, Vasey, P, Conry, R, Isaacs, R, Espinosa, E, Schueler, A, Massimini, G, and Dreno, B
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- 2020
23. Abstracts for the 38th annual emergencies in medicine conference
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Alali, SukainaAli, primary, Hsu, JeanW, additional, Akbar, Abraham, additional, Welch, RobertD, additional, Gibbs, Joseph, additional, Pollack, CharlesV, additional, Fanikos, J, additional, Chebolu, E, additional, Nguyen, Jennifer, additional, Fermann, GregoryJ, additional, Jivanjee, Mufaddal, additional, Williams, James, additional, Imhoff, BryanF, additional, Rising, KristinL, additional, Isaacs, R, additional, Zhongyang, Teo, additional, Mahan, CharlesE, additional, Le, Tinh, additional, Rosenblatt, Lauren, additional, Gueye, I, additional, and Peacock, WFrank, additional
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- 2021
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24. Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc
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Bridgen, D. T., Gilchrist, C. L., Richardson, W. J., Isaacs, R. E., Brown, C. R., Yang, K. L., Chen, J., and Setton, L. A.
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- 2013
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25. A randomized phase II study comparing capecitabine alone with capecitabine and oral cyclophosphamide in patients with advanced breast cancer-cyclox II
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Harvey, V. J., Sharples, K. J., Isaacs, R. J., Jameson, M. B., Jeffery, G. M., McLaren, B. R., Pollard, S., Riley, G. A., Simpson, A. B., Hinder, V. A., Scott, J. N., Dzhelali, M. V., and Findlay, M. P.
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- 2013
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26. The effect of monocyclic and bicyclic analogs of human parathyroid hormone (hPTH)-(1-31)NH2 on bone formation and mechanical strength in ovariectomized rats
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Morley, P., Whitfield, J. F., Willick, G. E., Ross, V., MacLean, S., Barbier, J-R., Isaacs, R. J., and Andreassen, T. T.
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- 2001
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27. The Stimulation of Vertebral and Tibial Bone Growth by the Parathyroid Hormone Fragments, hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2
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Whitfield, J. F., Morley, P., Fraher, L., Hodsman, A. B., Holdsworth, D. W., Watson, P. H., Willick, G. E., Barbier, J.-R., Gulam, M., Isaacs, R. J., MacLean, S., and Ross, V.
- Published
- 2000
- Full Text
- View/download PDF
28. Stimulation of Femoral Trabecular Bone Growth in Ovariectomized Rats by Human Parathyroid Hormone (hPTH)-(1-30)NH2
- Author
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Whitfield, J. F., Morley, P., Willick, G. E., MacLean, S., Ross, V., Barbier, J.-R., and Isaacs, R. J.
- Published
- 1999
- Full Text
- View/download PDF
29. Sprayer Type and Water Volume Influence Spatial Patterns of Pesticide Deposition and Control of Diseases and Insect Pests of Highbush Blueberries
- Author
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Wise, J. C., primary, Miles, L. A., additional, Acimovic, D., additional, Vandervoort, C., additional, Isaacs, R., additional, Miles, T.D., additional, and Schilder, A. M. C., additional
- Published
- 2020
- Full Text
- View/download PDF
30. IPM case studies: berry crops.
- Author
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Isaacs, R., primary and Woodford, J. A. T., additional
- Published
- 2007
- Full Text
- View/download PDF
31. Comparison of the Abilities of Human Parathyroid Hormone (hPTH)-(1-34) and [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2 to Stimulate Femoral Trabecular Bone Growth in Ovariectomized Rats
- Author
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Whitfield, J. F., Morley, P., Willick, G., MacLean, S., Ross, V., Isaacs, R. J., and Barbier, J.-R.
- Published
- 1998
- Full Text
- View/download PDF
32. Comparison of the Abilities of Human Parathyroid Hormone(1-31)NH2 and Human Parathyroid Hormone-Related Protein(1-31)NH2 to Stimulate Femoral Trabecular Bone Growth in Ovariectomized Rats
- Author
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Whitfield, J. F., Morley, P., Willick, G. E., Ross, V., Langille, R., MacLean, S., Barbier, J.-R., Isaacs, R. J., and Ohannessian-Barry, L.
- Published
- 1997
- Full Text
- View/download PDF
33. The Hypotensive Actions of Osteogenic and Nonosteogenic Parathyroid Hormone Fragments
- Author
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Whitfield, J. F., Morley, P., Ross, V., Preston, E., Soska, M., Barbier, J.-R., Isaacs, R. J., Maclean, S., Ohannessian-Barry, L., and Willick, G. E.
- Published
- 1997
- Full Text
- View/download PDF
34. Comparison of the ability of recombinant human parathyroid hormone, rhPTH-(1–84), and hPTH-(1–31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats
- Author
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Whitfield, J. F., Morley, P., Willick, G. E., Ross, V., MacLean, S., Barbier, J. -R., Isaacs, R. J., and Ohannessian-Barry, L.
- Published
- 1997
- Full Text
- View/download PDF
35. Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(1–31)NH2 (Ostabolin)
- Author
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Whitfield, J. F., Morley, P., Willick, G. E., Ross, V., Barbier, J. -R., Isaacs, R. J., and Ohannessian-Barry, L.
- Published
- 1996
- Full Text
- View/download PDF
36. Safety and Efficacy of Posaconazole in the Long-Term Treatment of Azole-Refractory Oropharyngeal and Esophageal Candidiasis in Patients with HIV Infection
- Author
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Vazquez, J. A., Skiest, D. J., Tissot-Dupont, H., Lennox, J. L., Boparai, N., and Isaacs, R.
- Published
- 2007
37. Restoration of severely depleted femoral trabecular bone in ovariectomized rats by parathyroid hormone-(1–34)
- Author
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Whitfield, J. F., Morley, P., Ross, V., Isaacs, R. J., and Rixon, R. H.
- Published
- 1995
- Full Text
- View/download PDF
38. The Relative Anticaries Effectiveness of Three Fluoride-Containing Dentifrices in Puerto Rico
- Author
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Stookey, G. K., Mau, M. S., Isaacs, R. L., Gonzalez-Gierbolini, C., Bartizek, R. D., and Biesbrock, A. R.
- Published
- 2004
39. Evaluation of Several Techniques for the Detection of Secondary Caries Adjacent to Amalgam Restorations
- Author
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Ando, M., González-Cabezas, C., Isaacs, R. L., Eckert, G. J., and Stookey, G. K.
- Published
- 2004
40. Health-care associated pneumonia acquired outside the ICU: results of a randomized, double-blind study comparing Ertapenem and Cefepime
- Author
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Friedland, I., Isaacs, R., Moll, J., Adeyi, B., and Woods, G.
- Published
- 2003
41. Serious community-acquired pneumonia in patients with chronic obstructive pulmonary disease: utility of Ertapenem
- Author
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Woods, G., Isaacs, R., McCarroll, K., and Friedland, I.
- Published
- 2003
42. Ertapenem for treatment of CAP caused by Gram-negative enteric pathogens
- Author
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Woods, G., Isaacs, R., McCarroll, K., and Friedland, I.
- Published
- 2003
43. Ertapenem 1 g once a day is highly effective for treatment of community-acquired and mixed infections in adults with diabetes
- Author
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Isaacs, R., Gesser, R., Teppler, H., Friedland, I., McCarroll, K., and Woods, G.
- Published
- 2003
44. A double-blind placebo-controlled randomized phase III trial of 5-fluorouracil and leucovorin, plus or minus trimetrexate, in previously untreated patients with advanced colorectal cancer
- Author
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Blanke, C. D., Shultz, J., Cox, J., Modiano, M., Isaacs, R., Kasimis, B., Schilsky, R., Fleagle, J., Moore, M., Kemeny, N., Carlin, D., Hammershaimb, L., and Haller, D.
- Published
- 2002
45. Heat and light in the childhood spanking debate
- Author
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Isaacs, R. Lee
- Published
- 2000
46. Comparison of Explorer and Loupes for Caries Examinations: 105
- Author
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Isaacs, R., Kelly, S., Mau, M., and Stookey, G.
- Published
- 1999
47. Bevacizumab as adjuvant treatment for colon cancer: Updated results from the AVANT phase III study by the GERCOR group
- Author
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André, T., primary, Vernerey, D., additional, Im, S.-A., additional, Bodoky, G.M., additional, Buzzoni, R., additional, Reingold, S., additional, Rivera, F., additional, McKendrick, J., additional, Scheithauer, W., additional, Geva, R., additional, Fountzilas, G., additional, Yong, W.P., additional, Isaacs, R., additional, Österlund, P., additional, Liang, J.-T., additional, Creemers, G.-J., additional, Van Cutsem, E., additional, Cunningham, D., additional, Tabernero, J., additional, and De Gramont, A., additional
- Published
- 2019
- Full Text
- View/download PDF
48. MON-108 BEDSIDE LUNG ULTRASOUND AND BIOIMPEDANCE SPECTROSCOPY FOR ASSESSMENT OF VOLUME STATUS IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS.
- Author
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MALHOTRA, A., primary, Isaacs, R., additional, Rajamanickam, T., additional, and Singla, S., additional
- Published
- 2019
- Full Text
- View/download PDF
49. An in vitro Comparison between Laser Fluorescence and Visual Examination for Detection of Demineralization in Occlusal Pits and Fissures
- Author
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Ferreira Zandoná, A. G., Analoui, M., Beiswanger, B. B., Isaacs, R. L., Kafrawy, A. H., Eckert, G. J., and Stookey, G. K.
- Published
- 1998
- Full Text
- View/download PDF
50. Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies.
- Author
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Helmberger T., Findlay M.P.N., Isaacs R., O'Donnell A., Perez D., Rodriguez J., Vera-Garcia R., Amin P., Bloomgarden D., Bui J., Carlisle J., Chai S., Chen Y.-J., Chuong M., Coveler A., Facchini F., Frenette G., Frick J., Garofalo M., George B., Gordon M., Gulec S., Hannigan J., Holtzman M., Kaubisch A., Kaiser A., Kooy T., Limentani S., Margolis J., Martin R., Ozer H., Padia S., Rilling W., Savin M., Schneiderman E., Seeger G., Shibata S., Smith R., Wang E., Whiting S., Aghmesheh M., Cooray P., Feeney K., Lim L., Singh M., Underhill C., Durand A., Faivre S., Ferru A., Hammel P., Bremer C., De Wit M., Ayala H., Heching N., Shani A., Granetto C., Masi G., Mosconi S., Numico G., Trogu A., Kim Y.H., Sae-Won H., Fragoso M., Tan I., Casado A.R., Liang J.T., Liu J.H., Ades S., Auber M., Boland P., Bowers C., Crain M., Dowling K., Iyer R., Ratner L., Sanchez F., Stoltzfus P., Westcott M., Segelov E., Strickland A., Gibbs P., Heinemann V., Sharma N., Taieb J., Ricke J., Peeters M., Robinson B.A., Jackson C., Gebski V., Van Buskirk M., Zhao H., van Hazel G., Brown M., Burge M., Cardaci G., Clarke S., Eliadis P., Ferguson T., Ganju V., James P., Karapetis C., Liauw W., Marx G., Matos M., Nott L., Pavlakis N., Powell A., Price T., Ransom D., Shannon J., Singhal N., Walpole E., Craninx M., Delaunoit T., Deleporte A., Ferrante M., Geboes K., Hendlisz A., Hendrickx K., De Man M., Monsaert E., Moons V., Polus M., Boucher E., Balosso J., Chevallier P., Louafi S., Pracht M., Rebischung C., Smith D., Terrebonne E., Bruch H.-R., Gehbauer G., Ko Y.-D., Kroning H., Lammert F., Nusch A., Pluntke S., Ridwelski K., Riera-Knorrenschild J., Riess H., Riera J.R., Sauerbruch T., Scheidhauer K., Stotzer O., Tatsch K., Vehling-Kaiser U., Vogl T., Beny A., Geva R., Shacham-Shmueli E., Stemmer S., Tichler T., Wolf I., Angelelli B., Martoni A., Helmberger T., Findlay M.P.N., Isaacs R., O'Donnell A., Perez D., Rodriguez J., Vera-Garcia R., Amin P., Bloomgarden D., Bui J., Carlisle J., Chai S., Chen Y.-J., Chuong M., Coveler A., Facchini F., Frenette G., Frick J., Garofalo M., George B., Gordon M., Gulec S., Hannigan J., Holtzman M., Kaubisch A., Kaiser A., Kooy T., Limentani S., Margolis J., Martin R., Ozer H., Padia S., Rilling W., Savin M., Schneiderman E., Seeger G., Shibata S., Smith R., Wang E., Whiting S., Aghmesheh M., Cooray P., Feeney K., Lim L., Singh M., Underhill C., Durand A., Faivre S., Ferru A., Hammel P., Bremer C., De Wit M., Ayala H., Heching N., Shani A., Granetto C., Masi G., Mosconi S., Numico G., Trogu A., Kim Y.H., Sae-Won H., Fragoso M., Tan I., Casado A.R., Liang J.T., Liu J.H., Ades S., Auber M., Boland P., Bowers C., Crain M., Dowling K., Iyer R., Ratner L., Sanchez F., Stoltzfus P., Westcott M., Segelov E., Strickland A., Gibbs P., Heinemann V., Sharma N., Taieb J., Ricke J., Peeters M., Robinson B.A., Jackson C., Gebski V., Van Buskirk M., Zhao H., van Hazel G., Brown M., Burge M., Cardaci G., Clarke S., Eliadis P., Ferguson T., Ganju V., James P., Karapetis C., Liauw W., Marx G., Matos M., Nott L., Pavlakis N., Powell A., Price T., Ransom D., Shannon J., Singhal N., Walpole E., Craninx M., Delaunoit T., Deleporte A., Ferrante M., Geboes K., Hendlisz A., Hendrickx K., De Man M., Monsaert E., Moons V., Polus M., Boucher E., Balosso J., Chevallier P., Louafi S., Pracht M., Rebischung C., Smith D., Terrebonne E., Bruch H.-R., Gehbauer G., Ko Y.-D., Kroning H., Lammert F., Nusch A., Pluntke S., Ridwelski K., Riera-Knorrenschild J., Riess H., Riera J.R., Sauerbruch T., Scheidhauer K., Stotzer O., Tatsch K., Vehling-Kaiser U., Vogl T., Beny A., Geva R., Shacham-Shmueli E., Stemmer S., Tichler T., Wolf I., Angelelli B., and Martoni A.
- Abstract
The primary tumor side is emerging as a prognostic factor for patients with liver metastatic colorectal cancer (mCRC). In a combined analysis of data from 2 randomized studies, the addition of selective internal radiation therapy to first-line chemotherapy in patients with mCRC was associated with statistically and clinically significant overall survival gains for patients with a right-sided primary tumor. Background(s): The primary tumor side is emerging as a major prognostic factor for patients with metastatic colorectal cancer (mCRC). We examined the survival data from 2 randomized studies to determine whether the outcomes differ between patients with mCRC with right-sided primary (RSP) tumors and those with left-sided primary (LSP) tumors after selective internal radiation therapy (SIRT) plus mFOLFOX6 (folinic acid [leucovorin], 5-fluorouracil, oxaliplatin) chemotherapy, versus chemotherapy alone. Patients and Methods: Separate and combined analyses were performed on the data from the SIRFLOX and FOXFIRE global trials, which compared chemotherapy plus SIRT with chemotherapy alone for patients with mCRC liver metastases. The primary tumor side data were prospectively collected. The principal outcome measure was overall survival (OS) stratified by treatment and primary tumor side. Result(s): In the combined analysis of all 739 patients enrolled, SIRT had no effect on OS (median OS, 24.3 vs. 24.6 months; hazard ratio [HR], 1.021; P =.810). For the 179 patients (24.2%) with a RSP tumor, OS was improved with the addition of SIRT (median, 22.0 vs. 17.1 months HR, 0.641; P =.008). The addition of SIRT was not associated with a significant difference in OS among the 540 patients with a LSP tumor (median, 24.6 vs. 26.6 months; HR, 1.120; P =.264). A test of treatment interaction by primary tumor side was statistically significant for RSP and SIRT (P =.002). Conclusion(s): The addition of SIRT for patients with RSP tumors, but not for those with LSP tumors, was associated
- Published
- 2018
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