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33 results on '"Isaacs, Krystyna"'

1. Women Empowered to Connect with Addiction Resources and Engage in Evidence-based Treatment (WE-CARE): A Usability and Feasibility Study of a Mobile Health Application for the Universal Screening of Alcohol, Substance Use, Depression and Anxiety. (Preprint)

Author

Isaacs, Krystyna, primary, Shifflett, Autumn, additional, Patel, Kajal, additional, Karpisek, Lacey, additional, Cui, Yi, additional, Lawental, Maayan, additional, Wernette, Golfo Tzilos, additional, Borsari, Brian, additional, Chang, Katie, additional, and Ma, Tony, additional

Published
2024
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3. Editorial: Maternal substance and alcohol use and contextual issues.

Author

Yukiko Washio, Williams, Petal Petersen, and Isaacs, Krystyna R.

Subjects
SUDDEN infant death syndrome, HEALTH facilities, MENTAL health services, MENTAL illness, PRENATAL alcohol exposure, ABRUPTIO placentae
Abstract

This article explores the effects of substance and alcohol use during pregnancy on the health of mothers and infants, as well as the relationship between substance use and contextual factors. It emphasizes the negative outcomes such as miscarriage, low birth weight, and stillbirth associated with substance and alcohol use during pregnancy. The article also emphasizes the importance of interventions that address the psychosocial and cultural issues related to substance use during pregnancy. The document provides a list of references from various scientific articles that cover topics such as substance abuse, violence, HIV, and maternal health, including the impact of substance abuse and violence on women's mental health, the effects of alcohol and drug use during pregnancy on fetal development, and the potential consequences of cannabis legalization in South Africa. The references also discuss the intersection of these issues with the COVID-19 pandemic and its potential effects on pregnant and postpartum women. [Extracted from the article]

Published
2024
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5. Usability and Acceptability Testing of a Plan of Safe Care in a Mobile Health Platform

Author

Isaacs, Krystyna R., Bajracharya, Elina, Taylor, Shantae, Chung, Katie, Washio, Yukiko, Parker, Trenee, Paul, David A., Ma, Tony X., Isaacs, Krystyna R., Bajracharya, Elina, Taylor, Shantae, Chung, Katie, Washio, Yukiko, Parker, Trenee, Paul, David A., and Ma, Tony X.

Abstract

Purpose: Women who are pregnant or parenting while recovering from substance use disorder (SUD) are at risk for insufficient recovery support. With the federal mandate, implementation has been left to each state for the Plan of Safe Care (POSC), leading to challenges in providing comprehensive care coordination and meeting federal reporting requirements. Methods: This research tests the usability and acceptability of a POSC platform, called SAFE4BOTH, which combines a mobile health (mHealth) app for use by mothers with substance use disorder (MSUD) with a web-based case management system for use by stakeholders to reduce the issue of fragmented postnatal maternal and infant care. The platform was designed to enable access to services, improve reporting task workflow, and assist in improving interactions between mothers and service providers. After applying a user-centered design approach, the usability and acceptability of the SAFE4BOTH platform were evaluated using focus groups, interviews, and a System Usability Scale (SUS). The evaluation involved four staff members from a Medication for Addiction Treatment clinic (comprising of three case management workers and one peer counselor), four state employees of the Delaware Division of Family Services, and 20 mothers with MSUD who had delivered infants in need of a POSC. Features tested in the SAFE4BOTH platform included a secure, web-based POSC, a contingency management-based reward system, a micro-learning library, a resources locator, a chat messaging and videoconferencing system, a directory for contact management, a QR code reader, use of an appointment compliance system engaging geofencing, and an enhanced calendar. Family services and treatment center staff accessed SAFE4BOTH from their laptops or tablets, and MSUD accessed SAFE4BOTH from their phones. Results: Family services staff, treatment center staff, and MSUD participants rated SAFE4BOTH as usable and acceptable with average System Usability Scale scores

Published
2023

32. The appetite suppressant dfenfluramine induces apoptosis in human serotonergic cells

Author

Bengel, Dietmar, Isaacs, Krystyna R., Heils, Armin, Lesch, Klaus-Peter, and Murphy, Dennis L.

Abstract

FENFLURAMINE is an amphetamine analogue which has been widely used in the treatment of obesity. In rodents, non-human primates, and humans, fenfluramine is associated with some indices of neurotoxicity, as well as pulmonary hypertension and cardiac valve pathology. In the present study, d-fenfluramine was found to be cytotoxic to the serotonin (5-HT) transporter (5-HTT) expressing human placental choriocarcinoma cells. d-Fenfluramine caused DNA fragmentation and apoptosis. Apoptosis was not observed after the 5-HTT had been blocked by fluoxetine, indicating that intact 5-HTT function is required for d-fenfluramine to induce programmed cell death. These observations in a human cell line may reflect a possible mechanism associated with the risks of fenfluramine administration in several species, including humans.

Published
1998

33. Editorial: Maternal substance and alcohol use and contextual issues.

Author

Washio Y, Petersen Williams P, and Isaacs KR

Abstract

Competing Interests: Author KI was employed by the company SciConsult Solutions. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Published
2024
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