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Magnetic resonance imaging (MRI) is the standard modality to understand human brain structure and function in vivo (antemortem). Decades of research in human neuroimaging has led to the widespread development of methods and tools to provide automated volume-based segmentations and surface-based parcellations which help localize brain functions to specialized anatomical regions. Recently ex vivo (postmortem) imaging of the brain has opened-up avenues to study brain structure at sub-millimeter ultra high-resolution revealing details not possible to observe with in vivo MRI. Unfortunately, there has been limited methodological development in ex vivo MRI primarily due to lack of datasets and limited centers with such imaging resources. Therefore, in this work, we present one-of-its-kind dataset of 82 ex vivo T2w whole brain hemispheres MRI at 0.3 mm isotropic resolution spanning Alzheimer's disease and related dementias. We adapted and developed a fast and easy-to-use automated surface-based pipeline to parcellate, for the first time, ultra high-resolution ex vivo brain tissue at the native subject space resolution using the Desikan-Killiany-Tourville (DKT) brain atlas. This allows us to perform vertex-wise analysis in the template space and thereby link morphometry measures with pathology measurements derived from histology. We will open-source our dataset docker container, Jupyter notebooks for ready-to-use out-of-the-box set of tools and command line options to advance ex vivo MRI clinical brain imaging research on the project webpage.

There has been a significant societal push towards sustainable practices, including in computing. Modern interactive workloads such as geo-distributed web-services exhibit various spatiotemporal and performance flexibility, enabling the possibility to adapt the location, time, and intensity of processing to align with the availability of renewable and low-carbon energy. An example is a web application hosted across multiple cloud regions, each with varying carbon intensity based on their local electricity mix. Distributed load-balancing enables the exploitation of low-carbon energy through load migration across regions, reducing web applications carbon footprint. In this paper, we present CASPER, a carbon-aware scheduling and provisioning system that primarily minimizes the carbon footprint of distributed web services while also respecting their Service Level Objectives (SLO). We formulate CASPER as an multi-objective optimization problem that considers both the variable carbon intensity and latency constraints of the network. Our evaluation reveals the significant potential of CASPER in achieving substantial reductions in carbon emissions. Compared to baseline methods, CASPER demonstrates improvements of up to 70% with no latency performance degradation.

In recent years, there has been an increased emphasis on reducing the carbon emissions from electricity consumption. Many organizations have set ambitious targets to reduce the carbon footprint of their operations as a part of their sustainability goals. The carbon footprint of any consumer of electricity is computed as the product of the total energy consumption and the carbon intensity of electricity. Third-party carbon information services provide information on carbon intensity across regions that consumers can leverage to modulate their energy consumption patterns to reduce their overall carbon footprint. In addition, to accelerate their decarbonization process, large electricity consumers increasingly acquire power purchase agreements (PPAs) from renewable power plants to obtain renewable energy credits that offset their "brown" energy consumption. There are primarily two methods for attributing carbon-free energy, or renewable energy credits, to electricity consumers: location-based and market-based. These two methods yield significantly different carbon intensity values for various consumers. As there is a lack of consensus which method to use for carbon-free attribution, a concurrent application of both approaches is observed in practice. In this paper, we show that such concurrent applications can cause discrepancies in the carbon savings reported by carbon optimization techniques. Our analysis across three state-of-the-art carbon optimization techniques shows possible overestimation of up to 55.1% in the carbon reductions reported by the consumers and even increased emissions for consumers in some cases. We also find that carbon optimization techniques make different decisions under the market-based method and location-based method, and the market-based method can yield up to 28.2% less carbon savings than those claimed by the location-based method for consumers without PPAs.

Federated Learning (FL) distributes machine learning (ML) training across many edge devices to reduce data transfer overhead and protect data privacy. Since FL model training may span millions of devices and is thus resource-intensive, prior work has focused on improving its resource efficiency to optimize time-to-accuracy. However, prior work generally treats all resources the same, while, in practice, they may incur widely different costs, which instead motivates optimizing cost-to-accuracy. To address the problem, we design CEFL, which uses adaptive cost-aware client selection policies to optimize an arbitrary cost metric when training FL models. Our policies extend and combine prior work on utility-based client selection and critical learning periods by making them cost-aware. We demonstrate CEFL by designing carbon-efficient FL, where energy's carbon-intensity is the cost, and show that it i) reduces carbon emissions by 93\% and reduces training time by 50% compared to random client selection and ii) reduces carbon emissions by 80%, while only increasing training time by 38%, compared to a state-of-the-art approach that optimizes training time.

To reduce their environmental impact, cloud datacenters' are increasingly focused on optimizing applications' carbon-efficiency, or work done per mass of carbon emitted. To facilitate such optimizations, we present Carbon Containers, a simple system-level facility, which extends prior work on power containers, that automatically regulates applications' carbon emissions in response to variations in both their workload's intensity and their energy's carbon-intensity. Specifically, \carbonContainerS enable applications to specify a maximum carbon emissions rate (in g$\cdot$CO$_2$e/hr), and then transparently enforce this rate via a combination of vertical scaling, container migration, and suspend/resume while maximizing either energy-efficiency or performance. Carbon Containers are especially useful for applications that i) must continue running even during high-carbon periods, and ii) execute in regions with few variations in carbon-intensity. These low-variability regions also tend to have high average carbon-intensity, which increases the importance of regulating carbon emissions. We implement a Carbon Containers prototype by extending Linux Containers to incorporate the mechanisms above and evaluate it using real workload traces and carbon-intensity data from multiple regions. We compare Carbon Containers with prior work that regulates carbon emissions by suspending/resuming applications during high/low carbon periods. We show that Carbon Containers are more carbon-efficient and improve performance while maintaining similar carbon emissions., Comment: ACM Symposium on Cloud Computing (SoCC)

Datacenter capacity is growing exponentially to satisfy the increasing demand for emerging computationally-intensive applications, such as deep learning. This trend has led to concerns over datacenters' increasing energy consumption and carbon footprint. The basic prerequisite for optimizing a datacenter's energy- and carbon-efficiency is accurately monitoring and attributing energy consumption to specific users and applications. Since datacenter servers tend to be multi-tenant, i.e., they host many applications, server- and rack-level power monitoring alone does not provide insight into their resident applications' energy usage and carbon emissions. At the same time, current application-level energy monitoring and attribution techniques are intrusive: they require privileged access to servers and require coordinated support in hardware and software, which is not always possible in cloud. To address the problem, we design WattScope, a system for non-intrusively estimating the power consumption of individual applications using external measurements of a server's aggregate power usage without requiring direct access to the server's operating system or applications. Our key insight is that, based on an analysis of production traces, the power characteristics of datacenter workloads, e.g., low variability, low magnitude, and high periodicity, are highly amenable to disaggregation of a server's total power consumption into application-specific values. WattScope adapts and extends a machine learning-based technique for disaggregating building power and applies it to server- and rack-level power meter measurements in data centers. We evaluate WattScope's accuracy on a production workload and show that it yields high accuracy, e.g., often <10% normalized mean absolute error, and is thus a potentially useful tool for datacenters in externally monitoring application-level power usage., Comment: Accepted to Performance'23

Many organizations, including governments, utilities, and businesses, have set ambitious targets to reduce carbon emissions for their Environmental, Social, and Governance (ESG) goals. To achieve these targets, these organizations increasingly use power purchase agreements (PPAs) to obtain renewable energy credits, which they use to compensate for the ``brown'' energy consumed from the grid. However, the details of these PPAs are often private and not shared with important stakeholders, such as grid operators and carbon information services, who monitor and report the grid's carbon emissions. This often results in incorrect carbon accounting, where the same renewable energy production could be factored into grid carbon emission reports and separately claimed by organizations that own PPAs. Such ``double counting'' of renewable energy production could lead organizations with PPAs to understate their carbon emissions and overstate their progress toward sustainability goals, and also provide significant challenges to consumers using common carbon reduction measures to decrease their carbon footprint. Unfortunately, there is no consensus on accurately computing the grid's carbon intensity by properly accounting for PPAs. The goal of our work is to shed quantitative and qualitative light on the renewable energy attribution and the incorrect carbon intensity estimation problems.

This paper addresses the problem of improving POS tagging of transcripts of speech from clinical populations. In contrast to prior work on parsing and POS tagging of transcribed speech, we do not make use of an in domain treebank for training. Instead, we train on an out of domain treebank of newswire using data augmentation techniques to make these structures resemble natural, spontaneous speech. We trained a parser with and without the augmented data and tested its performance using manually validated POS tags in clinical speech produced by patients with various types of neurodegenerative conditions.

Major innovations in computing have been driven by scaling up computing infrastructure, while aggressively optimizing operating costs. The result is a network of worldwide datacenters that consume a large amount of energy, mostly in an energy-efficient manner. Since the electric grid powering these datacenters provided a simple and opaque abstraction of an unlimited and reliable power supply, the computing industry remained largely oblivious to the carbon intensity of the electricity it uses. Much like the rest of the society, it generally treated the carbon intensity of the electricity as constant, which was mostly true for a fossil fuel-driven grid. As a result, the cost-driven objective of increasing energy-efficiency -- by doing more work per unit of energy -- has generally been viewed as the most carbon-efficient approach. However, as the electric grid is increasingly powered by clean energy and is exposing its time-varying carbon intensity, the most energy-efficient operation is no longer necessarily the most carbon-efficient operation. There has been a recent focus on exploiting the flexibility of computing's workloads -- along temporal, spatial, and resource dimensions -- to reduce carbon emissions, which comes at the cost of either performance or energy efficiency. In this paper, we discuss the trade-offs between energy efficiency and carbon efficiency in exploiting computing's flexibility and show that blindly optimizing for energy efficiency is not always the right approach., Comment: 2nd Workshop on Sustainable Computer Systems (HotCarbon'23)

To halt further climate change, computing, along with the rest of society, must reduce, and eventually eliminate, its carbon emissions. Recently, many researchers have focused on estimating and optimizing computing's \emph{embodied carbon}, i.e., from manufacturing computing infrastructure, in addition to its \emph{operational carbon}, i.e., from executing computations, primarily because the former is much larger than the latter but has received less research attention. Focusing attention on embodied carbon is important because it can incentivize i) operators to increase their infrastructure's efficiency and lifetime and ii) downstream suppliers to reduce their own operational carbon, which represents upstream companies' embodied carbon. Yet, as we discuss, focusing attention on embodied carbon may also introduce harmful incentives, e.g., by significantly overstating real carbon reductions and complicating the incentives for directly optimizing operational carbon. This position paper's purpose is to mitigate such harmful incentives by highlighting both the promise and potential pitfalls of optimizing embodied carbon., Comment: 2nd Workshop on Sustainable Computer Systems (HotCarbon'23)

Cloud platforms have been focusing on reducing their carbon emissions by shifting workloads across time and locations to when and where low-carbon energy is available. Despite the prominence of this idea, prior work has only quantified the potential of spatiotemporal workload shifting in narrow settings, i.e., for specific workloads in select regions. In particular, there has been limited work on quantifying an upper bound on the ideal and practical benefits of carbon-aware spatiotemporal workload shifting for a wide range of cloud workloads. To address the problem, we conduct a detailed data-driven analysis to understand the benefits and limitations of carbon-aware spatiotemporal scheduling for cloud workloads. We utilize carbon intensity data from 123 regions, encompassing most major cloud sites, to analyze two broad classes of workloads -- batch and interactive -- and their various characteristics, e.g., job duration, deadlines, and SLOs. Our findings show that while spatiotemporal workload shifting can reduce workloads' carbon emissions, the practical upper bounds of these carbon reductions are currently limited and far from ideal. We also show that simple scheduling policies often yield most of these reductions, with more sophisticated techniques yielding little additional benefit. Notably, we also find that the benefit of carbon-aware workload scheduling relative to carbon-agnostic scheduling will decrease as the energy supply becomes "greener"., Comment: EuroSys'24: Nineteenth European Conference on Computer Systems, 2024

Environmentally-powered computer systems operate on renewable energy harvested from their environment, such as solar or wind, and stored in batteries. While harvesting environmental energy has long been necessary for small-scale embedded systems without access to external power sources, it is also increasingly important in designing sustainable larger-scale systems for edge applications. For sustained operations, such systems must consider not only the electrical energy but also the thermal energy available in the environment in their design and operation. Unfortunately, prior work generally ignores the impact of thermal effects, and instead implicitly assumes ideal temperatures. To address the problem, we develop a thermodynamic model that captures the interplay of electrical and thermal energy in environmentally-powered computer systems. The model captures the effect of environmental conditions, the system's physical properties, and workload scheduling on performance. In evaluating our model, we distill the thermal effects that impact these systems using a small-scale prototype and a programmable incubator. We then leverage our model to show how considering these thermal effects in designing and operating environmentally-powered computer systems of varying scales can improve their energy-efficiency, performance, and availability., Comment: The 14th ACM International Conference on Future Energy Systems (e-Energy '23), June 20--23, 2023, Orlando, FL, USA

Postmortem MRI allows brain anatomy to be examined at high resolution and to link pathology measures with morphometric measurements. However, automated segmentation methods for brain mapping in postmortem MRI are not well developed, primarily due to limited availability of labeled datasets, and heterogeneity in scanner hardware and acquisition protocols. In this work, we present a high resolution of 135 postmortem human brain tissue specimens imaged at 0.3 mm$^{3}$ isotropic using a T2w sequence on a 7T whole-body MRI scanner. We developed a deep learning pipeline to segment the cortical mantle by benchmarking the performance of nine deep neural architectures, followed by post-hoc topological correction. We then segment four subcortical structures (caudate, putamen, globus pallidus, and thalamus), white matter hyperintensities, and the normal appearing white matter. We show generalizing capabilities across whole brain hemispheres in different specimens, and also on unseen images acquired at 0.28 mm^3 and 0.16 mm^3 isotropic T2*w FLASH sequence at 7T. We then compute localized cortical thickness and volumetric measurements across key regions, and link them with semi-quantitative neuropathological ratings. Our code, Jupyter notebooks, and the containerized executables are publicly available at: https://pulkit-khandelwal.github.io/exvivo-brain-upenn, Comment: Preprint submitted to NeuroImage Project website: https://pulkit-khandelwal.github.io/exvivo-brain-upenn

When developing tools for automated cortical segmentation, the ability to produce topologically correct segmentations is important in order to compute geometrically valid morphometry measures. In practice, accurate cortical segmentation is challenged by image artifacts and the highly convoluted anatomy of the cortex itself. To address this, we propose a novel deep learning-based cortical segmentation method in which prior knowledge about the geometry of the cortex is incorporated into the network during the training process. We design a loss function which uses the theory of Laplace's equation applied to the cortex to locally penalize unresolved boundaries between tightly folded sulci. Using an ex vivo MRI dataset of human medial temporal lobe specimens, we demonstrate that our approach outperforms baseline segmentation networks, both quantitatively and qualitatively., Comment: Accepted at the 28th biennial international conference on Information Processing in Medical Imaging (IPMI 2023)

Cloud platforms are increasing their emphasis on sustainability and reducing their operational carbon footprint. A common approach for reducing carbon emissions is to exploit the temporal flexibility inherent to many cloud workloads by executing them in periods with the greenest energy and suspending them at other times. Since such suspend-resume approaches can incur long delays in job completion times, we present a new approach that exploits the elasticity of batch workloads in the cloud to optimize their carbon emissions. Our approach is based on the notion of "carbon scaling," similar to cloud autoscaling, where a job dynamically varies its server allocation based on fluctuations in the carbon cost of the grid's energy. We develop a greedy algorithm for minimizing a job's carbon emissions via carbon scaling that is based on the well-known problem of marginal resource allocation. We implement a CarbonScaler prototype in Kubernetes using its autoscaling capabilities and an analytic tool to guide the carbon-efficient deployment of batch applications in the cloud. We then evaluate CarbonScaler using real-world machine learning training and MPI jobs on a commercial cloud platform and show that it can yield i) 51% carbon savings over carbon-agnostic execution; ii) 37% over a state-of-the-art suspend-resume policy; and iii) 8% over the best static scaling policy.

Cloud platforms' rapid growth is raising significant concerns about their carbon emissions. To reduce emissions, future cloud platforms will need to increase their reliance on renewable energy sources, such as solar and wind, which have zero emissions but are highly unreliable. Unfortunately, today's energy systems effectively mask this unreliability in hardware, which prevents applications from optimizing their carbon-efficiency, or work done per kilogram of carbon emitted. To address this problem, we design an "ecovisor", which virtualizes the energy system and exposes software-defined control of it to applications. An ecovisor enables each application to handle clean energy's unreliability in software based on its own specific requirements. We implement a small-scale ecovisor prototype that virtualizes a physical energy system to enable software-based application-level i) visibility into variable grid carbon-intensity and renewable generation and ii) control of server power usage and battery charging/discharging. We evaluate the ecovisor approach by showing how multiple applications can concurrently exercise their virtual energy system in different ways to better optimize carbon-efficiency based on their specific requirements compared to a general system-wide policy.

The demand for computing is continuing to grow exponentially. This growth will translate to exponential growth in computing's energy consumption unless improvements in its energy-efficiency can outpace increases in its demand. Yet, after decades of research, further improving energy-efficiency is becoming increasingly challenging, as it is already highly optimized. As a result, at some point, increases in computing demand are likely to outpace increases in its energy-efficiency, potentially by a wide margin. Such exponential growth, if left unchecked, will position computing as a substantial contributor to global carbon emissions. While prominent technology companies have recognized the problem and sought to reduce their carbon emissions, they understandably focus on their successes, which has the potential to inadvertently convey the false impression that this is now, or will soon be, a solved problem. Such false impressions can be counterproductive if they serve to discourage further research in this area, since, as we discuss, eliminating computing's, and more generally society's, carbon emissions is far from a solved problem. To better understand the problem's scope, this paper distills the fundamental trends that determine computing's carbon footprint and their implications for achieving sustainable computing., Comment: Accepted to HotCarbon'22

Solar energy is now the cheapest form of electricity in history. Unfortunately, significantly increasing the grid's fraction of solar energy remains challenging due to its variability, which makes balancing electricity's supply and demand more difficult. While thermal generators' ramp rate -- the maximum rate that they can change their output -- is finite, solar's ramp rate is essentially infinite. Thus, accurate near-term solar forecasting, or nowcasting, is important to provide advance warning to adjust thermal generator output in response to solar variations to ensure a balanced supply and demand. To address the problem, this paper develops a general model for solar nowcasting from abundant and readily available multispectral satellite data using self-supervised learning. Specifically, we develop deep auto-regressive models using convolutional neural networks (CNN) and long short-term memory networks (LSTM) that are globally trained across multiple locations to predict raw future observations of the spatio-temporal data collected by the recently launched GOES-R series of satellites. Our model estimates a location's future solar irradiance based on satellite observations, which we feed to a regression model trained on smaller site-specific solar data to provide near-term solar photovoltaic (PV) forecasts that account for site-specific characteristics. We evaluate our approach for different coverage areas and forecast horizons across 25 solar sites and show that our approach yields errors close to that of a model using ground-truth observations., Comment: 18 pages

Ex vivo MRI of the brain provides remarkable advantages over in vivo MRI for visualizing and characterizing detailed neuroanatomy. However, automated cortical segmentation methods in ex vivo MRI are not well developed, primarily due to limited availability of labeled datasets, and heterogeneity in scanner hardware and acquisition protocols. In this work, we present a high resolution 7 Tesla dataset of 32 ex vivo human brain specimens. We benchmark the cortical mantle segmentation performance of nine neural network architectures, trained and evaluated using manually-segmented 3D patches sampled from specific cortical regions, and show excellent generalizing capabilities across whole brain hemispheres in different specimens, and also on unseen images acquired at different magnetic field strength and imaging sequences. Finally, we provide cortical thickness measurements across key regions in 3D ex vivo human brain images. Our code and processed datasets are publicly available at https://github.com/Pulkit-Khandelwal/picsl-ex-vivo-segmentation., Comment: Ex vivo analysis framework (work in progress 2022 at the University of Pennsylvania)